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Tytuł :
Leukemogenesis via aberrant self-renewal by the MLL/AEP-mediated transcriptional activation system.
Autorzy :
Yokoyama A; Tsuruoka Metabolomics Laboratory, National Cancer Center, Tsuruoka, Japan.; National Cancer Center Research Institute, Tokyo, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Oct; Vol. 112 (10), pp. 3935-3944. Date of Electronic Publication: 2021 Aug 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Self Renewal/*physiology
Hematopoietic Stem Cells/*physiology
Histone-Lysine N-Methyltransferase/*genetics
Leukemia/*etiology
Myeloid-Lymphoid Leukemia Protein/*genetics
Transcriptional Activation/*physiology
Acetylation ; Cell Differentiation ; Cell Self Renewal/genetics ; Cellular Senescence ; CpG Islands/genetics ; DNA-Binding Proteins/metabolism ; E1A-Associated p300 Protein/metabolism ; Gene Rearrangement ; Hematopoiesis/physiology ; Histone-Lysine N-Methyltransferase/metabolism ; Histones/metabolism ; Humans ; Leukemia/prevention & control ; Lysine/metabolism ; Multipotent Stem Cells/physiology ; Mutation ; Myeloid-Lymphoid Leukemia Protein/metabolism ; Positive Transcriptional Elongation Factor B/metabolism ; Proto-Oncogene Proteins/metabolism ; RNA Polymerase II/metabolism ; Transcriptional Elongation Factors/metabolism
Czasopismo naukowe
Tytuł :
Circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF.
Autorzy :
Chen Z; School of Life Sciences, Zhengzhou University, Zhengzhou, China.
Lu T; University of Chinese Academy of Sciences, Beijing, China.; CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Huang L; Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Wang Z; School of Life Sciences, Zhengzhou University, Zhengzhou, China.
Yan Z; School of Basic Medical Sciences, Henan University, Kaifeng, China.
Guan Y; School of Life Sciences, Zhengzhou University, Zhengzhou, China.
Hu W; School of Life Sciences, Zhengzhou University, Zhengzhou, China.
Fan Z; University of Chinese Academy of Sciences, Beijing, China.; CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Zhu P; School of Life Sciences, Zhengzhou University, Zhengzhou, China.; State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan Province, China.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2021 Oct 01; Vol. 131 (19).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Self Renewal*
Liver Neoplasms/*etiology
MafF Transcription Factor/*physiology
Neoplastic Stem Cells/*physiology
RNA, Circular/*physiology
Animals ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Lysine Acetyltransferase 5/genetics ; Lysine Acetyltransferase 5/physiology ; MafF Transcription Factor/genetics ; Mice ; Mice, Inbred C57BL ; Neoplasm Metastasis ; Promoter Regions, Genetic
Czasopismo naukowe
Tytuł :
[Identification of potential regulatory genes for embryonic stem cell self-renewal and pluripotency by random forest].
Autorzy :
Zeng P; School of Basic Medical Science, Southern Medical University, Guangzhou 510515, China.
Tang X; Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China.
Wu T; Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China.
Tian Q; Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China.
Li M; School of Basic Medical Science, Southern Medical University, Guangzhou 510515, China.
Ding J; Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China.
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Źródło :
Nan fang yi ke da xue xue bao = Journal of Southern Medical University [Nan Fang Yi Ke Da Xue Xue Bao] 2021 Aug 20; Vol. 41 (8), pp. 1234-1238.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Self Renewal*
Mouse Embryonic Stem Cells*
Animals ; Cell Differentiation ; Cell Survival ; Genes, Regulator ; Mice
Czasopismo naukowe
Tytuł :
Continuous expression of reprogramming factors induces and maintains mouse pluripotency without specific growth factors and signaling inhibitors.
Autorzy :
Mao Y; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Wang L; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.
Zhong B; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; College of Life Science, Northeast Agricultural University of China, Harbin, China.
Yang N; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Li Z; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.
Cui T; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.
Feng G; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.
Li W; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.
Zhang Y; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.
Zhou Q; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, China.
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Źródło :
Cell proliferation [Cell Prolif] 2021 Aug; Vol. 54 (8), pp. e13090. Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Self Renewal*/drug effects
Cellular Reprogramming*
Transcription Factors/*metabolism
Animals ; Cell Proliferation/drug effects ; Doxycycline/pharmacology ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Gene Editing ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Leukemia Inhibitory Factor/pharmacology ; Mice ; Mice, Transgenic ; Mouse Embryonic Stem Cells/cytology ; Mouse Embryonic Stem Cells/metabolism ; Protein Kinase Inhibitors/pharmacology ; Teratoma/metabolism ; Teratoma/pathology ; Transcription Factors/genetics ; Transcriptome/drug effects
Czasopismo naukowe
Tytuł :
The role of P2Y12 in the kinetics of microglial self-renewal and maturation in the adult visual cortex in vivo.
Autorzy :
Mendes MS; Department of Neuroscience, University of Rochester Medical Center, Rochester, United States.
Le L; Department of Neuroscience, University of Rochester Medical Center, Rochester, United States.
Atlas J; Department of Neuroscience, University of Rochester Medical Center, Rochester, United States.
Brehm Z; Department of Biostatistics, University of Rochester Medical Center, Rochester, United States.
Ladron-de-Guevara A; Department of Neuroscience, University of Rochester Medical Center, Rochester, United States.; Department of Biomedical Engineering, University of Rochester, Rochester, United States.
Matei E; Department of Neuroscience, University of Rochester Medical Center, Rochester, United States.
Lamantia C; Department of Neuroscience, University of Rochester Medical Center, Rochester, United States.
McCall MN; Department of Biostatistics, University of Rochester Medical Center, Rochester, United States.
Majewska AK; Department of Neuroscience, University of Rochester Medical Center, Rochester, United States.; Center for Visual Science, University of Rochester, Rochester, United States.
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Źródło :
ELife [Elife] 2021 Jul 12; Vol. 10. Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cell Self Renewal*
Microglia/*metabolism
Receptors, Purinergic P2Y12/*metabolism
Visual Cortex/*metabolism
Animals ; Brain/immunology ; Brain/metabolism ; Cell Movement ; Kinetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microglia/immunology ; Models, Theoretical ; Signal Transduction ; Visual Cortex/immunology
Czasopismo naukowe
Tytuł :
Tempo-spatial regulation of the Wnt pathway by FAM13A modulates the stemness of alveolar epithelial progenitors.
Autorzy :
Lin X; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Li Y; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA; Guangzhou First People's Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong, 510180, China.
Gong L; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Yun JH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA; The Division of Pulmonary and Critical Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Xu S; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Tesfaigzi Y; The Division of Pulmonary and Critical Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Qiao D; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Zhou X; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. Electronic address: .
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Źródło :
EBioMedicine [EBioMedicine] 2021 Jul; Vol. 69, pp. 103463. Date of Electronic Publication: 2021 Jul 03.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Self Renewal*
Wnt Signaling Pathway*
Alveolar Epithelial Cells/*metabolism
GTPase-Activating Proteins/*metabolism
Pulmonary Emphysema/*metabolism
Stem Cells/*metabolism
Alveolar Epithelial Cells/cytology ; Animals ; Female ; GTPase-Activating Proteins/genetics ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Pulmonary Emphysema/etiology ; Stem Cells/cytology ; Stem Cells/physiology ; Tobacco Smoke Pollution/adverse effects
Czasopismo naukowe
Tytuł :
Symmetric and asymmetric activation of hematopoietic stem cells.
Autorzy :
Loeffler D; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Schroeder T
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Źródło :
Current opinion in hematology [Curr Opin Hematol] 2021 Jul 01; Vol. 28 (4), pp. 262-268.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Asymmetric Cell Division*
Cell Differentiation*
Cell Self Renewal*
Hematopoietic Stem Cells/*cytology
Hematopoietic Stem Cells/*metabolism
Animals ; Autophagosomes ; Cell Proliferation ; Energy Metabolism ; Humans ; Lysosomes ; Mitophagy ; Signal Transduction
Czasopismo naukowe
Tytuł :
Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility.
Autorzy :
Koester J; Max Planck Institute for Biology of Ageing, Cologne, Germany.; Cologne Excellence Cluster for Stress Responses in Ageing-associated diseases (CECAD), University of Cologne, Cologne, Germany.
Miroshnikova YA; Max Planck Institute for Biology of Ageing, Cologne, Germany.; Cologne Excellence Cluster for Stress Responses in Ageing-associated diseases (CECAD), University of Cologne, Cologne, Germany.; Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.; Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Ghatak S; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Chacón-Martínez CA; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Morgner J; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Li X; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Atanassov I; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Altmüller J; Cologne Center for Genomics, University of Cologne, Cologne, Germany.
Birk DE; Department of Molecular Pharmacology & Physiology, University of South Florida, Morsani College of Medicine, Tampa, FL, USA.
Koch M; Institute for Dental Research and Oral Musculoskeletal Research, Center for Biochemistry, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Bloch W; Molecular and Cellular Sport Medicine, German Sport University Cologne, Cologne, Germany.
Bartusel M; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Niessen CM; Cologne Excellence Cluster for Stress Responses in Ageing-associated diseases (CECAD), University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Department of Dermatology, Center for Molecular Medicine, University of Cologne, Cologne, Germany.
Rada-Iglesias A; Cologne Excellence Cluster for Stress Responses in Ageing-associated diseases (CECAD), University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Institute of Biomedicine and Biotechnology of Cantabria (IBBTEC), University of Cantabria/CSIC, Cantabria, Spain.
Wickström SA; Max Planck Institute for Biology of Ageing, Cologne, Germany. .; Cologne Excellence Cluster for Stress Responses in Ageing-associated diseases (CECAD), University of Cologne, Cologne, Germany. .; Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland. .; Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland. .; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland. .
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Źródło :
Nature cell biology [Nat Cell Biol] 2021 Jul; Vol. 23 (7), pp. 771-781. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*/genetics
Cell Self Renewal*/genetics
Cellular Senescence*/genetics
Chromatin Assembly and Disassembly*
Promoter Regions, Genetic*
Stem Cell Niche*
Hair Follicle/*physiology
Stem Cells/*physiology
Animals ; Cell Lineage ; Cells, Cultured ; Extracellular Matrix/physiology ; Gene Silencing ; Hair Follicle/cytology ; Hair Follicle/metabolism ; Male ; Mechanotransduction, Cellular ; Mice, Inbred C57BL ; Mice, Knockout ; Skin Aging ; Stem Cells/metabolism ; Stress, Mechanical ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Critical Role of Lkb1 in the Maintenance of Alveolar Macrophage Self-Renewal and Immune Homeostasis.
Autorzy :
Wang Q; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Chen S; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Li T; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Yang Q; Department of Hematology, The First Affiliated Hospital of Kunming Medical University, Hematology Research Center of Yunnan Province, Kunming, China.
Liu J; Central Laboratory, Fujian Medical University Union Hospital, Fuzhou, China.
Tao Y; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Meng Y; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Chen J; Central Laboratory, Fujian Medical University Union Hospital, Fuzhou, China.
Feng X; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Han Z; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Shi M; Department of Hematology, The First Affiliated Hospital of Kunming Medical University, Hematology Research Center of Yunnan Province, Kunming, China.
Huang H; Central Laboratory, Fujian Medical University Union Hospital, Fuzhou, China.
Han M; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Jiang E; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Apr 22; Vol. 12, pp. 629281. Date of Electronic Publication: 2021 Apr 22 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Self Renewal*
Asthma/*enzymology
Lung/*enzymology
Macrophages, Alveolar/*enzymology
Pneumonia, Bacterial/*enzymology
Protein-Serine-Threonine Kinases/*metabolism
Staphylococcal Infections/*enzymology
Animals ; Asthma/genetics ; Asthma/immunology ; CD11 Antigens/genetics ; CD11 Antigens/metabolism ; Disease Models, Animal ; Homeostasis ; Interleukin-17/genetics ; Interleukin-17/metabolism ; Lung/immunology ; Lung/microbiology ; Macrophages, Alveolar/immunology ; Macrophages, Alveolar/microbiology ; Mice, Inbred C57BL ; Mice, Knockout ; Neutrophil Infiltration ; Pneumonia, Bacterial/genetics ; Pneumonia, Bacterial/immunology ; Pneumonia, Bacterial/microbiology ; Protein-Serine-Threonine Kinases/genetics ; Signal Transduction ; Staphylococcal Infections/genetics ; Staphylococcal Infections/immunology ; Staphylococcal Infections/microbiology ; Transcriptome
Czasopismo naukowe
Tytuł :
Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function.
Autorzy :
Golden EJ; Department of Cell & Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States.; The Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, United States.
Larson ED; The Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, United States.; Department of Otolaryngology, University of Colorado Anschutz Medical Campus, Aurora, United States.
Shechtman LA; Department of Cell & Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States.; The Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, United States.
Trahan GD; Department of Pediatrics, Section of Hematology, Oncology, and Bone Marrow Transplant, University of Colorado Anschutz Medical Campus, Aurora, United States.
Gaillard D; Department of Cell & Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States.; The Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, United States.
Fellin TJ; Department of Cell & Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States.; The Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, United States.
Scott JK; Department of Cell & Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States.; The Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, United States.
Jones KL; Department of Pediatrics, Section of Hematology, Oncology, and Bone Marrow Transplant, University of Colorado Anschutz Medical Campus, Aurora, United States.
Barlow LA; Department of Cell & Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States.; The Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, United States.
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Źródło :
ELife [Elife] 2021 May 19; Vol. 10. Date of Electronic Publication: 2021 May 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Differentiation*
Cell Self Renewal*
Epithelial Cells/*metabolism
Hedgehog Proteins/*metabolism
Stem Cells/*metabolism
Taste Buds/*metabolism
Animals ; Animals, Newborn ; Cell Adhesion ; Cell Lineage ; Cell Movement ; Female ; Gene Expression Regulation, Developmental ; Hedgehog Proteins/genetics ; Hepatocyte Nuclear Factor 3-alpha/genetics ; Hepatocyte Nuclear Factor 3-alpha/metabolism ; Hepatocyte Nuclear Factor 3-beta/genetics ; Hepatocyte Nuclear Factor 3-beta/metabolism ; Keratin-14/genetics ; Keratin-14/metabolism ; Male ; Signal Transduction ; Taste ; Taste Buds/cytology ; Transcriptome
Czasopismo naukowe
Tytuł :
Knockdown of ZEB1 reverses cancer stem cell properties in prostate cancer cells.
Autorzy :
Pérez G; Laboratory of Cellular and Molecular Oncology, Department of Basic and Clinical Oncology, Faculty of Medicine, University of Chile, Santiago 8380453, Chile.
López-Moncada F; Laboratory of Endocrinology and Reproductive Biology, University of Chile Clinical Hospital, Faculty of Medicine, University of Chile, Santiago 8380453, Chile.
Indo S; Department of Medical Technology, Faculty of Medicine, University of Chile, Santiago 8380453, Chile.
Torres MJ; Laboratory of Cellular and Molecular Oncology, Department of Basic and Clinical Oncology, Faculty of Medicine, University of Chile, Santiago 8380453, Chile.
Castellón EA; Laboratory of Cellular and Molecular Oncology, Department of Basic and Clinical Oncology, Faculty of Medicine, University of Chile, Santiago 8380453, Chile.
Contreras HR; Laboratory of Cellular and Molecular Oncology, Department of Basic and Clinical Oncology, Faculty of Medicine, University of Chile, Santiago 8380453, Chile.
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Źródło :
Oncology reports [Oncol Rep] 2021 May; Vol. 45 (5). Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Self Renewal/*genetics
Gene Expression Regulation, Neoplastic/*genetics
Neoplastic Stem Cells/*pathology
Prostatic Neoplasms/*genetics
Zinc Finger E-box-Binding Homeobox 1/*metabolism
Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Cell Self Renewal/drug effects ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Knockdown Techniques ; Humans ; Male ; Prostate/cytology ; Prostate/pathology ; Prostatic Neoplasms/pathology ; Tumor Stem Cell Assay ; Zinc Finger E-box-Binding Homeobox 1/antagonists & inhibitors ; Zinc Finger E-box-Binding Homeobox 1/genetics
Czasopismo naukowe
Tytuł :
The role of heme oxygenase-1 in hematopoietic system and its microenvironment.
Autorzy :
Szade A; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Krakow, Poland. .
Szade K; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Krakow, Poland.
Mahdi M; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Krakow, Poland.
Józkowicz A; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Krakow, Poland.
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 May; Vol. 78 (10), pp. 4639-4651. Date of Electronic Publication: 2021 Mar 31.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Aging*
Cell Differentiation*
Cell Self Renewal*
Cellular Microenvironment*
Hematopoiesis*
Heme Oxygenase-1/*metabolism
Mesenchymal Stem Cells/*cytology
Animals ; Humans ; Mesenchymal Stem Cells/enzymology
Czasopismo naukowe
Tytuł :
DYRK1A Negatively Regulates CDK5-SOX2 Pathway and Self-Renewal of Glioblastoma Stem Cells.
Autorzy :
Chen B; Charles Perkins Centre and School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.
McCuaig-Walton D; Charles Perkins Centre and School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.
Tan S; Charles Perkins Centre and School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.
Montgomery AP; School of Chemistry, Faculty of Science, The University of Sydney, Sydney, NSW 2006, Australia.
Day BW; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD 4006, Australia.
Kassiou M; School of Chemistry, Faculty of Science, The University of Sydney, Sydney, NSW 2006, Australia.
Munoz L; Charles Perkins Centre and School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.
Recasens A; Charles Perkins Centre and School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 13; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 13.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Self Renewal*/drug effects
Cyclin-Dependent Kinase 5/*metabolism
Glioblastoma/*metabolism
Glioblastoma/*pathology
Neoplastic Stem Cells/*pathology
Protein-Serine-Threonine Kinases/*metabolism
Protein-Tyrosine Kinases/*metabolism
SOXB1 Transcription Factors/*metabolism
Bone Morphogenetic Protein 4/pharmacology ; Cell Differentiation/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Glioblastoma/genetics ; Humans ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
The ULK1 kinase, a necessary component of the pro-regenerative and anti-aging machinery in Hydra.
Autorzy :
Suknovic N; Department of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), Faculty of Sciences, University of Geneva, 30 Quai Ernest Ansermet, CH-1211, Geneva 4, Switzerland.
Tomczyk S; Department of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), Faculty of Sciences, University of Geneva, 30 Quai Ernest Ansermet, CH-1211, Geneva 4, Switzerland.
Colevret D; Department of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), Faculty of Sciences, University of Geneva, 30 Quai Ernest Ansermet, CH-1211, Geneva 4, Switzerland.
Perruchoud C; Department of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), Faculty of Sciences, University of Geneva, 30 Quai Ernest Ansermet, CH-1211, Geneva 4, Switzerland.
Galliot B; Department of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), Faculty of Sciences, University of Geneva, 30 Quai Ernest Ansermet, CH-1211, Geneva 4, Switzerland. Electronic address: .
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Źródło :
Mechanisms of ageing and development [Mech Ageing Dev] 2021 Mar; Vol. 194, pp. 111414. Date of Electronic Publication: 2020 Dec 15.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*/drug effects
Cell Self Renewal*/drug effects
Cellular Senescence*/drug effects
Autophagosomes/*enzymology
Autophagy-Related Protein-1 Homolog/*metabolism
Epithelial Cells/*enzymology
Hydra/*enzymology
Stem Cells/*enzymology
Animals ; Animals, Genetically Modified ; Autophagosomes/drug effects ; Autophagosomes/genetics ; Autophagy ; Autophagy-Related Protein-1 Homolog/antagonists & inhibitors ; Autophagy-Related Protein-1 Homolog/genetics ; Beclin-1/metabolism ; Epithelial Cells/drug effects ; Female ; Gene Knockdown Techniques ; Hydra/drug effects ; Hydra/genetics ; Male ; Phosphorylation ; Protein Kinase Inhibitors/pharmacology ; RNA Interference ; Signal Transduction ; Stem Cells/drug effects
Czasopismo naukowe
Tytuł :
LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells.
Autorzy :
Höpner SS; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Raykova A; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Radpour R; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Amrein MA; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Koller D; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Baerlocher GM; Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Riether C; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Ochsenbein AF; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. .; Department for BioMedical Research, University of Bern, Bern, Switzerland. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 16; Vol. 12 (1), pp. 1065. Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*/drug effects
Cell Self Renewal*/drug effects
Cell Self Renewal*/genetics
Hematopoietic Stem Cells/*metabolism
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*pathology
Lymphotoxin beta Receptor/*metabolism
Neoplastic Stem Cells/*pathology
Tumor Necrosis Factor Ligand Superfamily Member 14/*metabolism
Animals ; Antigens, CD34/metabolism ; Cell Cycle/drug effects ; Cell Cycle/genetics ; Cell Proliferation/drug effects ; DNA Damage ; Fluorouracil/pharmacology ; Gene Expression Regulation, Leukemic/drug effects ; Hematopoietic Stem Cells/drug effects ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Mice, Inbred C57BL ; Mice, Knockout ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Depletion of Trp53 and Cdkn2a Does Not Promote Self-Renewal in the Mammary Gland but Amplifies Proliferation Induced by TNF-α.
Autorzy :
van Weele LJ; Institute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA, USA.
Scheeren FA; Institute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA, USA.
Cai S; Institute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA, USA.
Kuo AH; Institute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA, USA.
Qian D; Institute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA, USA.
Ho WHD; Institute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA, USA; Department of Stem Cell Biotechnology, California State University Channel Islands, Camarillo, CA, USA.
Clarke MF; Institute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA, USA. Electronic address: .
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Źródło :
Stem cell reports [Stem Cell Reports] 2021 Feb 09; Vol. 16 (2), pp. 228-236. Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*
Cell Self Renewal*
Cyclin-Dependent Kinase Inhibitor p16/*metabolism
Epithelial Cells/*metabolism
Mammary Glands, Human/*metabolism
Tumor Suppressor Protein p53/*metabolism
Animals ; Carcinogenesis/metabolism ; Female ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Animal ; Organoids/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Interaction between DMRT1 and PLZF protein regulates self-renewal and proliferation in male germline stem cells.
Autorzy :
Wei Y; College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & Technology, Northwest A&F University, No. 3rd, Taicheng Road, Yangling, 712100, Shaanxi, China.
Yang D; College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & Technology, Northwest A&F University, No. 3rd, Taicheng Road, Yangling, 712100, Shaanxi, China.
Du X; College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & Technology, Northwest A&F University, No. 3rd, Taicheng Road, Yangling, 712100, Shaanxi, China.
Yu X; College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & Technology, Northwest A&F University, No. 3rd, Taicheng Road, Yangling, 712100, Shaanxi, China.
Zhang M; College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & Technology, Northwest A&F University, No. 3rd, Taicheng Road, Yangling, 712100, Shaanxi, China.
Tang F; College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & Technology, Northwest A&F University, No. 3rd, Taicheng Road, Yangling, 712100, Shaanxi, China.
Ma F; College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & Technology, Northwest A&F University, No. 3rd, Taicheng Road, Yangling, 712100, Shaanxi, China.
Li N; College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & Technology, Northwest A&F University, No. 3rd, Taicheng Road, Yangling, 712100, Shaanxi, China.
Bai C; Key Laboratory for Mammalian Reproductive Biology and Biotechnology, Ministry of Education, Inner Mongolia University, Hohhot, 010021, China.
Li G; Key Laboratory for Mammalian Reproductive Biology and Biotechnology, Ministry of Education, Inner Mongolia University, Hohhot, 010021, China.
Hua J; College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & Technology, Northwest A&F University, No. 3rd, Taicheng Road, Yangling, 712100, Shaanxi, China. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Feb; Vol. 476 (2), pp. 1123-1134. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Self Renewal*
Protein Interaction Domains and Motifs*
Spermatogenesis*
Promyelocytic Leukemia Zinc Finger Protein/*metabolism
Stem Cells/*cytology
Testis/*cytology
Transcription Factors/*metabolism
Animals ; Cell Proliferation ; Cells, Cultured ; Goats ; Humans ; Male ; Mice ; Mice, Inbred ICR ; Models, Animal ; Stem Cells/metabolism ; Testis/metabolism
Czasopismo naukowe
Tytuł :
Glucocorticoid agonists enhance retinal stem cell self-renewal and proliferation.
Autorzy :
Grisé KN; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada. .; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada. .
Bautista NX; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Jacques K; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Coles BLK; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.
van der Kooy D; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, M5S 1A8, Canada.
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Źródło :
Stem cell research & therapy [Stem Cell Res Ther] 2021 Jan 25; Vol. 12 (1), pp. 83. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Self Renewal*
Glucocorticoids*/pharmacology
Animals ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Mice ; Retina
Czasopismo naukowe
Tytuł :
Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self-renewal.
Autorzy :
Mullin NP; Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, UK.
Varghese J; Protein Phosphorylation and Ubiquitylation Unit, James Black Centre, School of Life Sciences, Dundee, UK.
Colby D; Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, UK.
Richardson JM; Institute of Quantitative Biology, Biochemistry and Biotechnology, Edinburgh, UK.
Findlay GM; Protein Phosphorylation and Ubiquitylation Unit, James Black Centre, School of Life Sciences, Dundee, UK.
Chambers I; Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, UK.
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Źródło :
FEBS letters [FEBS Lett] 2021 Jan; Vol. 595 (1), pp. 14-25. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Self Renewal*
Casein Kinase I/*metabolism
Mouse Embryonic Stem Cells/*cytology
Nanog Homeobox Protein/*metabolism
Amino Acid Sequence ; Animals ; Electrophoresis, Polyacrylamide Gel ; Mice ; Nanog Homeobox Protein/chemistry ; Nanog Homeobox Protein/genetics ; Phosphorylation
Czasopismo naukowe
Tytuł :
Steroid-dependent switch of OvoL/Shavenbaby controls self-renewal versus differentiation of intestinal stem cells.
Autorzy :
Al Hayek S; Faculty of Sciences III, Lebanese University, Tripoli, Lebanon.; Azm Center for Research in Biotechnology and its Applications, LBA3B, EDST, Lebanese University, Tripoli, Lebanon.; Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Toulouse, France.
Alsawadi A; Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Toulouse, France.
Kambris Z; Biology Department, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon.
Boquete JP; Global Health Institute, School of Life Sciences, Lausanne, Switzerland.
Bohère J; Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Toulouse, France.
Immarigeon C; Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Toulouse, France.
Ronsin B; Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Toulouse, France.
Plaza S; Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Toulouse, France.
Lemaitre B; Global Health Institute, School of Life Sciences, Lausanne, Switzerland.
Payre F; Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Toulouse, France.
Osman D; Faculty of Sciences III, Lebanese University, Tripoli, Lebanon.; Azm Center for Research in Biotechnology and its Applications, LBA3B, EDST, Lebanese University, Tripoli, Lebanon.
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Źródło :
The EMBO journal [EMBO J] 2021 Feb 15; Vol. 40 (4), pp. e104347. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
Cell Self Renewal*
DNA-Binding Proteins/*metabolism
Drosophila Proteins/*metabolism
Intestines/*physiology
Stem Cells/*cytology
Steroids/*pharmacology
Transcription Factors/*metabolism
Animals ; DNA-Binding Proteins/genetics ; Drosophila ; Drosophila Proteins/genetics ; Female ; Gene Expression Regulation, Developmental ; Male ; Stem Cells/metabolism ; Transcription Factors/genetics
Czasopismo naukowe

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