Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""SERINE"" wg kryterium: Temat


Tytuł :
Unravelling the unfolding pathway of human Fas-activated serine/threonine kinase induced by urea.
Autorzy :
Alamry KA; Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Srivastava S; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
Shahbaaz M; South African Medical Research Council Bioinformatics Unit, South African National Bioinformatics Institute, University of the Western Cape, Bellville, Cape Town, South Africa.; Laboratory of Computational Modeling of Drugs, South Ural State University, Chelyabinsk, Russia.
Khan P; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
Gupta P; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
Syed SB; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
Azum N; Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Asiri AM; Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.; Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Islam A; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
Ahmad F; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
Hassan MI; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
Pokaż więcej
Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Sep; Vol. 39 (15), pp. 5516-5525. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Journal Article
MeSH Terms :
Protein-Serine-Threonine Kinases*
Urea*/pharmacology
Circular Dichroism ; Humans ; Protein Conformation ; Protein Denaturation ; Protein Folding ; Serine ; Thermodynamics
Czasopismo naukowe
Tytuł :
High SPINK4 Expression Predicts Poor Outcomes among Rectal Cancer Patients Receiving CCRT.
Autorzy :
Chen TJ; Department of Pathology, Chi Mei Medical Center, Tainan 710, Taiwan.; Department of Medical Technology, Chung Hwa University of Medical Technology, Tainan 717, Taiwan.; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
Tian YF; Division of Colon and Rectal Surgery, Department of Surgery, Chi Mei Medical Center, Tainan 710, Taiwan.
Chou CL; Division of Colon and Rectal Surgery, Department of Surgery, Chi Mei Medical Center, Tainan 710, Taiwan.
Chan TC; Department of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan.; National Institute of Cancer Research, National Health Research Institutes, Tainan 704, Taiwan.
He HL; Department of Pathology, Chi Mei Medical Center, Tainan 710, Taiwan.; Department of Optometry, Chung Hwa University of Medical Technology, Tainan 717, Taiwan.
Li WS; Department of Pathology, Chi Mei Medical Center, Tainan 710, Taiwan.; Department of Medical Technology, Chung Hwa University of Medical Technology, Tainan 717, Taiwan.
Tsai HH; Department of Pathology, Chi Mei Medical Center, Tainan 710, Taiwan.; Department of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan.
Li CF; Department of Pathology, Chi Mei Medical Center, Tainan 710, Taiwan.; Department of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan.; National Institute of Cancer Research, National Health Research Institutes, Tainan 704, Taiwan.; Institute of Precision Medicine, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.; Department of Pathology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Lai HY; Department of Pathology, Chi Mei Medical Center, Tainan 710, Taiwan.; Department of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan.
Pokaż więcej
Źródło :
Current oncology (Toronto, Ont.) [Curr Oncol] 2021 Jun 25; Vol. 28 (4), pp. 2373-2384. Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article
MeSH Terms :
Rectal Neoplasms*/drug therapy
Rectal Neoplasms*/therapy
Serine Proteinase Inhibitors*/therapeutic use
Biomarkers, Tumor/genetics ; Chemoradiotherapy ; Disease-Free Survival ; Humans ; Prospective Studies ; Serine Peptidase Inhibitors, Kazal Type
Czasopismo naukowe
Tytuł :
Structural Basis of Covalent Inhibitory Mechanism of TMPRSS2-Related Serine Proteases by Camostat.
Autorzy :
Sun G; College of Chemistry, Fuzhou Universitygrid.411604.6, Fuzhou, Fujian, People's Republic of China.
Sui Y; College of Chemistry, Fuzhou Universitygrid.411604.6, Fuzhou, Fujian, People's Republic of China.
Zhou Y; College of Chemistry, Fuzhou Universitygrid.411604.6, Fuzhou, Fujian, People's Republic of China.
Ya J; College of Chemistry, Fuzhou Universitygrid.411604.6, Fuzhou, Fujian, People's Republic of China.
Yuan C; College of Biological Science and Engineering, Fuzhou Universitygrid.411604.6, Fuzhou, Fujian, People's Republic of China.
Jiang L; College of Chemistry, Fuzhou Universitygrid.411604.6, Fuzhou, Fujian, People's Republic of China.; Fujian Key Laboratory of Marine Enzyme Engineering, Fuzhou Universitygrid.411604.6, Fuzhou, Fujian, People's Republic of China.
Huang M; College of Chemistry, Fuzhou Universitygrid.411604.6, Fuzhou, Fujian, People's Republic of China.
Pokaż więcej
Źródło :
Journal of virology [J Virol] 2021 Sep 09; Vol. 95 (19), pp. e0086121. Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Esters/*pharmacology
Guanidines/*pharmacology
SARS-CoV-2/*drug effects
Serine Endopeptidases/*chemistry
Serine Endopeptidases/*pharmacology
Serine Proteases/*pharmacology
Antiviral Agents/chemistry ; COVID-19/drug therapy ; COVID-19/prevention & control ; Carcinoma, Squamous Cell ; Esters/chemistry ; Esters/metabolism ; Guanidines/chemistry ; Guanidines/metabolism ; Humans ; Molecular Dynamics Simulation ; Mouth Neoplasms ; Protein Domains ; Sequence Alignment ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Serine Proteases/chemistry ; Serine Proteases/metabolism ; Serine Proteinase Inhibitors/chemistry ; Serine Proteinase Inhibitors/pharmacology ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł :
Identification of hot spot residues on serine-arginine protein kinase-1 by molecular dynamics simulation studies.
Autorzy :
Chandra A; School of Biotechnology, Gautam Buddha University, Greater Noida, Uttar Pradesh, India.
Goyal N; School of Biotechnology, Gautam Buddha University, Greater Noida, Uttar Pradesh, India.
Qamar I; School of Biotechnology, Gautam Buddha University, Greater Noida, Uttar Pradesh, India.
Singh N; School of Biotechnology, Gautam Buddha University, Greater Noida, Uttar Pradesh, India.
Pokaż więcej
Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Mar; Vol. 39 (5), pp. 1579-1587. Date of Electronic Publication: 2020 Mar 04.
Typ publikacji :
Journal Article
MeSH Terms :
Arginine Kinase*
Protein-Serine-Threonine Kinases*/metabolism
Arginine ; Molecular Dynamics Simulation ; Nuclear Proteins/metabolism ; Phosphorylation ; Protein Kinases ; RNA-Binding Proteins ; Serine ; Serine-Arginine Splicing Factors/genetics
Czasopismo naukowe
Tytuł :
A phase I study of high dose camostat mesylate in healthy adults provides a rationale to repurpose the TMPRSS2 inhibitor for the treatment of COVID-19.
Autorzy :
Kitagawa J; Clinical Pharmacology, Ono Pharmaceutical Co., Ltd., Osaka, Japan.; Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Fukuoka, Japan.
Arai H; Clinical Pharmacology, Ono Pharmaceutical Co., Ltd., Osaka, Japan.
Iida H; Clinical Pharmacology, Ono Pharmaceutical Co., Ltd., Osaka, Japan.
Mukai J; Clinical Pharmacology, Ono Pharmaceutical Co., Ltd., Osaka, Japan.
Furukawa K; Clinical Pharmacology, Ono Pharmaceutical Co., Ltd., Osaka, Japan.
Ohtsu S; Pharmacokinetic Research, Ono Pharmaceutical Co., Ltd., Ibaraki, Japan.
Nakade S; Clinical Pharmacology, Ono Pharmaceutical Co., Ltd., Osaka, Japan.
Hikima T; Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Fukuoka, Japan.
Haranaka M; SOUSEIKAI Hakata Clinic, Fukuoka, Japan.
Uemura N; Department of Clinical Pharmacology and Therapeutics, Faculty of Medicine, Oita University, Oita, Japan.
Pokaż więcej
Źródło :
Clinical and translational science [Clin Transl Sci] 2021 Sep; Vol. 14 (5), pp. 1967-1976. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Clinical Trial, Phase I; Journal Article
MeSH Terms :
Drug Repositioning*
COVID-19/*drug therapy
Esters/*adverse effects
Guanidines/*adverse effects
Serine Proteinase Inhibitors/*administration & dosage
Administration, Oral ; Adolescent ; Adult ; Computer Simulation ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Esters/administration & dosage ; Esters/pharmacokinetics ; Food-Drug Interactions ; Guanidines/administration & dosage ; Guanidines/pharmacokinetics ; Healthy Volunteers ; Humans ; Male ; Middle Aged ; Models, Biological ; Serine Endopeptidases/metabolism ; Serine Proteinase Inhibitors/adverse effects ; Young Adult
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Neisseria meningitidis IgA1-specific serine protease exhibits novel cleavage activity against IgG3.
Autorzy :
Spoerry C; Department of Microbiology, Tumor, and Cell Biology, BioClinicum, Karolinska University Hospital , Stockholm, Sweden.
Karlsson J; Department of Microbiology, Tumor, and Cell Biology, BioClinicum, Karolinska University Hospital , Stockholm, Sweden.
Aschtgen MS; Department of Microbiology, Tumor, and Cell Biology, BioClinicum, Karolinska University Hospital , Stockholm, Sweden.
Loh E; Department of Microbiology, Tumor, and Cell Biology, BioClinicum, Karolinska University Hospital , Stockholm, Sweden.; Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University , Singapore, Singapore.
Pokaż więcej
Źródło :
Virulence [Virulence] 2021 Dec; Vol. 12 (1), pp. 389-403.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunoglobulin G/*metabolism
Neisseria meningitidis/*enzymology
Neisseria meningitidis/*genetics
Serine Endopeptidases/*metabolism
Serine Proteases/*metabolism
Humans ; Immunoglobulin G/immunology ; Meningococcal Infections/microbiology ; Neisseria meningitidis/immunology ; Neisseria meningitidis/pathogenicity ; Serine/metabolism ; Serine Proteases/genetics ; Serine Proteases/immunology
Czasopismo naukowe
Tytuł :
LRRK2 Loss-of-Function Variants in Patients with Rare Diseases: No Evidence for a Phenotypic Impact.
Autorzy :
Beetz C; CENTOGENE GmbH, Rostock, Germany.
Westenberger A; CENTOGENE GmbH, Rostock, Germany.; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Al-Ali R; CENTOGENE GmbH, Rostock, Germany.
Ameziane N; CENTOGENE GmbH, Rostock, Germany.
Alhashmi N; National Genetic Center, Royal Hospital, Muscat, Oman.
Boustany RM; Neurogenetics Program, AUBMC Special Kids Clinic and Division of Pediatric Neurology, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.; Department of Biochemistry and Molecular Genetics, American University of Beirut Medical Center, Beirut, Lebanon.
Al Mutairi F; Genetics and Precision Medicine Department, King Abdullah Specialist Children Hospital, King Abdulaziz Medical City, MNGHA, Riyadh, Saudi Arabia.; King Abdullah International Medical Research Center (KAIMRC), King Saud bin Abdulaziz University for Health Sciences, MNGHA, Riyadh, Saudi Arabia.
Alfadhel M; Genetics and Precision Medicine Department, King Abdullah Specialist Children Hospital, King Abdulaziz Medical City, MNGHA, Riyadh, Saudi Arabia.; King Abdullah International Medical Research Center (KAIMRC), King Saud bin Abdulaziz University for Health Sciences, MNGHA, Riyadh, Saudi Arabia.
Al-Hassnan Z; Department of Medical Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
AlSayed M; Department of Medical Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Kandaswamy KK; CENTOGENE GmbH, Rostock, Germany.
Paknia O; CENTOGENE GmbH, Rostock, Germany.
Skrahina V; CENTOGENE GmbH, Rostock, Germany.
Rolfs A; CENTOGENE GmbH, Rostock, Germany.; University of Rostock, Medical Faculty, Rostock, Germany.
Bauer P; CENTOGENE GmbH, Rostock, Germany.
Pokaż więcej
Źródło :
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2021 Apr; Vol. 36 (4), pp. 1029-1031. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Letter
MeSH Terms :
Protein-Serine-Threonine Kinases*
Rare Diseases*
Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics
Opinia redakcyjna
Tytuł :
The carboxyl-terminal region of coagulation serine proteases: A matter of cut and change.
Autorzy :
Branchini A; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
Pokaż więcej
Źródło :
Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2021 Apr; Vol. 19 (4), pp. 917-919.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Factor XI*
Serine Proteases*
Blood Coagulation ; Humans ; Protein Conformation, alpha-Helical ; Serine Endopeptidases
Czasopismo naukowe
Tytuł :
Serine Protease Inhibitors to Treat Lung Inflammatory Diseases.
Autorzy :
El Amri C; Sorbonne Université, Faculty of Sciences and Engineering, IBPS, UMR 8256 CNRS-UPMC, ERL INSERM U1164, Biological Adaptation and Ageing, Paris, France. .
Pokaż więcej
Źródło :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2021; Vol. 1304, pp. 215-226.
Typ publikacji :
Journal Article; Review
MeSH Terms :
COVID-19*
Serine Proteinase Inhibitors*/therapeutic use
Humans ; Lung ; Pandemics ; SARS-CoV-2 ; Serine Proteases
Czasopismo naukowe
Tytuł :
Association of leucine-rich repeat kinase 2 gene rs10878307 polymorphism and Parkinson's disease risk in South India-A meta-analysis and molecular dynamics simulation.
Autorzy :
Kuriakose B; Genetics Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, India.
K S; Department of Neurology, Chettinad Super Specialty Hospital, Chettinad Health City, Kelambakkam, India.
Rs AH; Genetics Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, India.
S V; Department of Neurology, Stanley Medical College and Hospital, Chennai, India.
A A; Department of Neurology, Stanley Medical College and Hospital, Chennai, India.
Kumar S; Department of Neurology, Sree Balajee Medical College and Hospital, Bharath University, Chennai, India.
Murugesan R; Drug Discovery Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, India.
V R; Genetics Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, India.
Ahmed SS; Drug Discovery Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, India.
Pokaż więcej
Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2020 Nov; Vol. 38 (18), pp. 5544-5552. Date of Electronic Publication: 2019 Dec 12.
Typ publikacji :
Letter; Meta-Analysis
MeSH Terms :
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/genetics
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/metabolism
Molecular Dynamics Simulation*
Parkinson Disease*/genetics
Humans ; India ; Leucine ; Protein-Serine-Threonine Kinases
Raport
Tytuł :
Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP-HIPK2 axis.
Autorzy :
Jin X; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Qing S; State Key Lab of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Li Q; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Zhuang H; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Shen L; Department of Urology, Department of Hematology, the Affiliated Yinzhou Renmin Hospital of Medical School of Ningbo University, Ningbo 315040, China.
Li J; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.
Qi H; Department of Urology, the Affiliated Yinzhou Second Hospital of Medical School of Ningbo University, Ningbo 315100, China.
Lin T; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Lin Z; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Wang J; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Cao X; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Yang J; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Ma Q; Translational Research Laboratory for Urology, the Key Laboratory of Ningbo City. Ningbo First Hospital, The affiliated hospital of Ningbo University, Ningbo, Zhejiang 315010, China.
Cong L; Department of Urology, Department of Hematology, the Affiliated Yinzhou Renmin Hospital of Medical School of Ningbo University, Ningbo 315040, China.
Xi Y; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Fang S; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Meng X; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Gong Z; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Ye M; The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Wang S; Department of Breast Surgery, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China.
Wang C; State Key Lab of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Gao K; Department of Clinical Laboratory, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China.
Pokaż więcej
Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 09; Vol. 49 (12), pp. 6788-6803.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genomic Instability*
Carrier Proteins/*metabolism
Nuclear Proteins/*genetics
Nuclear Proteins/*metabolism
Prostatic Neoplasms/*genetics
Prostatic Neoplasms/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Repressor Proteins/*genetics
Repressor Proteins/*metabolism
Ataxia Telangiectasia Mutated Proteins/metabolism ; Carrier Proteins/chemistry ; Cell Line, Tumor ; Chromosomal Proteins, Non-Histone/metabolism ; DNA Damage ; Histones/metabolism ; Humans ; Male ; Mutation ; Phosphorylation ; Prostatic Neoplasms/enzymology ; Prostatic Neoplasms/pathology ; Protein-Serine-Threonine Kinases/chemistry ; Serine/metabolism ; Ubiquitination
Czasopismo naukowe
Tytuł :
Structural leitmotif and functional variations of the structural catalytic core in (chymo)trypsin-like serine/cysteine fold proteinases.
Autorzy :
Denesyuk AI; Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center 'Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences', Pushchino, Moscow region 142290, Russia; Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Turku 20520, Finland. Electronic address: .
Permyakov SE; Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center 'Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences', Pushchino, Moscow region 142290, Russia.
Johnson MS; Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Turku 20520, Finland.
Permyakov EA; Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center 'Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences', Pushchino, Moscow region 142290, Russia.
Uversky VN; Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center 'Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences', Pushchino, Moscow region 142290, Russia; Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA. Electronic address: .
Denessiouk K; Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Turku 20520, Finland.
Pokaż więcej
Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 May 15; Vol. 179, pp. 601-609. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Cysteine Proteases/*chemistry
Serine Proteases/*chemistry
Amino Acid Sequence ; Binding Sites ; COVID-19/metabolism ; Catalysis ; Catalytic Domain ; Cysteine Proteases/metabolism ; Humans ; Models, Molecular ; SARS Virus/chemistry ; SARS Virus/metabolism ; SARS-CoV-2/chemistry ; SARS-CoV-2/metabolism ; Serine Endopeptidases/chemistry ; Serine Endopeptidases/metabolism ; Serine Proteases/metabolism ; Trypsin/metabolism
Czasopismo naukowe
Tytuł :
Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.
Autorzy :
Bao C; Biogen, Cambridge, MA, 02134, USA.
Bajrami B; Biogen, Cambridge, MA, 02134, USA.
Marcotte DJ; Biogen, Cambridge, MA, 02134, USA.
Chodaparambil JV; Biogen, Cambridge, MA, 02134, USA.
Kerns HM; Biogen, Cambridge, MA, 02134, USA.
Henderson J; Biogen, Cambridge, MA, 02134, USA.
Wei R; Biogen, Cambridge, MA, 02134, USA.
Gao B; Biogen, Cambridge, MA, 02134, USA.
Dillon GM; Biogen, Cambridge, MA, 02134, USA. .
Pokaż więcej
Źródło :
Cellular and molecular neurobiology [Cell Mol Neurobiol] 2021 May; Vol. 41 (4), pp. 669-685. Date of Electronic Publication: 2020 May 18.
Typ publikacji :
Journal Article
MeSH Terms :
Protein-Serine-Threonine Kinases/*metabolism
Amino Acid Sequence ; Animals ; Cerebral Cortex/pathology ; Epitopes/metabolism ; HEK293 Cells ; Humans ; Isoenzymes/chemistry ; Isoenzymes/metabolism ; Mice, Transgenic ; Neurons/metabolism ; Phosphopeptides/chemistry ; Phosphopeptides/metabolism ; Phosphoproteins/metabolism ; Phosphorylation ; Protein Binding ; Protein Domains ; Protein-Serine-Threonine Kinases/chemistry ; Proteomics ; Serine/metabolism ; Structural Homology, Protein ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Microbial alkaline serine proteases: Production, properties and applications.
Autorzy :
Matkawala F; Maharaja Ranjit Singh College of Professional Sciences, Khandwa Rd., Indore, 452001, India.
Nighojkar S; Mata Gujri College of Professional Studies, A.B. Road, Indore, 452001, India.
Kumar A; School of Biotechnology, Devi Ahilya University, Khandwa Road, Indore, 452001, India.
Nighojkar A; Maharaja Ranjit Singh College of Professional Sciences, Khandwa Rd., Indore, 452001, India. .
Pokaż więcej
Źródło :
World journal of microbiology & biotechnology [World J Microbiol Biotechnol] 2021 Mar 17; Vol. 37 (4), pp. 63. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Biotechnology*
Bacterial Proteins/*metabolism
Serine Endopeptidases/*metabolism
Detergents ; Endopeptidases/metabolism ; Fermentation ; Food Industry ; Hydrogen-Ion Concentration ; Hydrolysis ; Serine/metabolism ; Serine Proteases/metabolism ; Substrate Specificity ; Temperature
Czasopismo naukowe
Tytuł :
Structure of an affinity-matured inhibitory recombinant fab against urokinase plasminogen activator reveals basis of potency and specificity.
Autorzy :
Sevillano N; Department of Pharmaceutical Chemistry, University of California San Francisco, CA 94158, United States of America.
Bohn MF; Department of Pharmaceutical Chemistry, University of California San Francisco, CA 94158, United States of America.
Zimanyi M; Department of Pharmaceutical Chemistry, University of California San Francisco, CA 94158, United States of America.
Chen Y; Molecular Biophysics and Integrated Bioimaging, Environmental Genomics and Systems Biology, and Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Petzold C; Molecular Biophysics and Integrated Bioimaging, Environmental Genomics and Systems Biology, and Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Gupta S; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Ralston CY; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Craik CS; Department of Pharmaceutical Chemistry, University of California San Francisco, CA 94158, United States of America. Electronic address: .
Pokaż więcej
Źródło :
Biochimica et biophysica acta. Proteins and proteomics [Biochim Biophys Acta Proteins Proteom] 2021 Feb; Vol. 1869 (2), pp. 140562. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Recombinant Proteins/*ultrastructure
Serine Proteases/*chemistry
Serine Proteinase Inhibitors/*chemistry
Urokinase-Type Plasminogen Activator/*chemistry
Amino Acid Sequence/genetics ; Humans ; Quinuclidines/chemistry ; Quinuclidines/pharmacology ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Serine Endopeptidases/chemistry ; Serine Endopeptidases/ultrastructure ; Serine Proteases/genetics ; Serine Proteinase Inhibitors/pharmacology ; Urokinase-Type Plasminogen Activator/antagonists & inhibitors ; Urokinase-Type Plasminogen Activator/genetics
Czasopismo naukowe
Tytuł :
Two steps purification, biochemical characterization, thermodynamics and structure elucidation of thermostable alkaline serine protease from Nocardiopsis alba strain OM-5.
Autorzy :
Chauhan JV; UGC-CAS Department of Biosciences, Saurashtra University, Rajkot 360005, Gujarat, India.
Mathukiya RP; UGC-CAS Department of Biosciences, Saurashtra University, Rajkot 360005, Gujarat, India.
Singh SP; UGC-CAS Department of Biosciences, Saurashtra University, Rajkot 360005, Gujarat, India.
Gohel SD; UGC-CAS Department of Biosciences, Saurashtra University, Rajkot 360005, Gujarat, India. Electronic address: .
Pokaż więcej
Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Feb 01; Vol. 169, pp. 39-50. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article
MeSH Terms :
Serine Endopeptidases/*chemistry
Serine Endopeptidases/*isolation & purification
Actinobacteria/chemistry ; Bacterial Proteins/chemistry ; Bacterial Proteins/isolation & purification ; Detergents ; Endopeptidases/chemistry ; Endopeptidases/isolation & purification ; Enzyme Stability/physiology ; Hydrogen-Ion Concentration ; Kinetics ; Nocardiopsis/enzymology ; Nocardiopsis/metabolism ; Serine/chemistry ; Serine Proteases/isolation & purification ; Surface-Active Agents ; Temperature ; Thermodynamics
SCR Organism :
Nocardiopsis alba
Czasopismo naukowe
Tytuł :
Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex.
Autorzy :
Li S; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Xie T; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Liu P; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Wang L; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Gong X; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China. .
Pokaż więcej
Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Mar; Vol. 28 (3), pp. 249-257. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy*
Multiprotein Complexes*/chemistry
Multiprotein Complexes*/genetics
Multiprotein Complexes*/metabolism
Multiprotein Complexes*/ultrastructure
Membrane Proteins/*chemistry
Membrane Proteins/*metabolism
Serine C-Palmitoyltransferase/*chemistry
Serine C-Palmitoyltransferase/*metabolism
Acyl Coenzyme A/chemistry ; Acyl Coenzyme A/metabolism ; Acyl Coenzyme A/ultrastructure ; Binding Sites ; Biocatalysis ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/ultrastructure ; Models, Molecular ; Mutation ; Pyridoxal Phosphate/chemistry ; Pyridoxal Phosphate/metabolism ; Reproducibility of Results ; Serine/chemistry ; Serine/metabolism ; Serine C-Palmitoyltransferase/genetics ; Serine C-Palmitoyltransferase/ultrastructure ; Substrate Specificity
Czasopismo naukowe
Tytuł :
LRRK2 Loss-of-Function Variants: When Less Is More.
Autorzy :
Usnich T; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Westenberger A; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Pokaż więcej
Źródło :
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2020 Oct; Vol. 35 (10), pp. 1754. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Protein-Serine-Threonine Kinases*
Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics
Czasopismo naukowe
Tytuł :
Necroptosis activates UPR sensors without disrupting their binding with GRP78.
Autorzy :
Liang W; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Qi W; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Geng Y; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Wang L; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Zhao J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Zhu K; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Wu G; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Zhang Z; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Pan H; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Qian L; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Yuan J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China; .
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Sep 28; Vol. 118 (39).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Necroptosis*
Unfolded Protein Response*
Endoribonucleases/*metabolism
Heat-Shock Proteins/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Receptor-Interacting Protein Serine-Threonine Kinases/*metabolism
eIF-2 Kinase/*metabolism
Apoptosis ; Endoplasmic Reticulum ; Endoplasmic Reticulum Stress ; Endoribonucleases/genetics ; HT29 Cells ; Heat-Shock Proteins/genetics ; Humans ; Protein-Serine-Threonine Kinases/genetics ; RNA Splicing ; Receptor-Interacting Protein Serine-Threonine Kinases/genetics ; X-Box Binding Protein 1/genetics ; eIF-2 Kinase/genetics
Czasopismo naukowe
Tytuł :
Recent advances in development of hetero-bivalent kinase inhibitors.
Autorzy :
Lee S; College of Pharmacy, CHA University, Pocheon-si, Gyeonggi-do, 11160, Republic of Korea.
Kim J; College of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Jo J; College of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Chang JW; Department of Pharmacology & Chemical Biology, School of Medicine, Emory University, Atlanta, GA, USA; Department of Hematology & Medical Oncology, School of Medicine, Emory University, Atlanta, GA, USA; Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Sim J; College of Pharmacy, Chungnam National University, Daejeon, 34134, Republic of Korea. Electronic address: .
Yun H; College of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea. Electronic address: .
Pokaż więcej
Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Apr 15; Vol. 216, pp. 113318. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Protein Kinase Inhibitors/*chemistry
Protein-Serine-Threonine Kinases/*antagonists & inhibitors
Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein-Serine-Threonine Kinases/metabolism ; Receptor, EphA1/antagonists & inhibitors ; Receptor, EphA1/metabolism ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/metabolism ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/metabolism ; src-Family Kinases/antagonists & inhibitors ; src-Family Kinases/metabolism
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies