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Title:
Numerous Serine/Threonine Kinases Affect Blood Cell Homeostasis in Drosophila melanogaster .
Authors:
Deichsel S; Department of Molecular Genetics, Institute of Biology, University of Hohenheim, 70599 Stuttgart, Germany.
Gahr BM; Department of Molecular Genetics, Institute of Biology, University of Hohenheim, 70599 Stuttgart, Germany.
Mastel H; Department of Molecular Genetics, Institute of Biology, University of Hohenheim, 70599 Stuttgart, Germany.
Preiss A; Institute of Biology, University of Hohenheim, 70599 Stuttgart, Germany.
Nagel AC; Department of Molecular Genetics, Institute of Biology, University of Hohenheim, 70599 Stuttgart, Germany.
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Source:
Cells [Cells] 2024 Mar 26; Vol. 13 (7). Date of Electronic Publication: 2024 Mar 26.
Publication Type:
Journal Article
MeSH Terms:
Protein Serine-Threonine Kinases*/metabolism
Drosophila Proteins*/metabolism
Animals ; Drosophila melanogaster/metabolism ; Blood Cells/metabolism ; Homeostasis ; Serine/metabolism ; Threonine/metabolism
Academic Journal
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Title:
Targeted Library of Phosphonic-Type Inhibitors of Human Neutrophil Elastase.
Authors:
Torzyk-Jurowska K; Division of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.
Ciekot J; Department of Experimental Oncology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.
Winiarski L; Division of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2024 Mar 01; Vol. 29 (5). Date of Electronic Publication: 2024 Mar 01.
Publication Type:
Journal Article
MeSH Terms:
Leukocyte Elastase*/metabolism
Serine Proteases*
Humans ; Cathepsin G ; Myeloblastin/chemistry ; Serine Proteinase Inhibitors/pharmacology
Academic Journal
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Title:
Ligand-Based Design of Selective Peptidomimetic uPA and TMPRSS2 Inhibitors with Arg Bioisosteres.
Authors:
Müller P; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudinger Weg 5, D-55128 Mainz, Germany.
Zimmer C; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudinger Weg 5, D-55128 Mainz, Germany.
Frey A; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudinger Weg 5, D-55128 Mainz, Germany.
Holzmann G; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudinger Weg 5, D-55128 Mainz, Germany.
Weldert AC; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudinger Weg 5, D-55128 Mainz, Germany.
Schirmeister T; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudinger Weg 5, D-55128 Mainz, Germany.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 23; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 23.
Publication Type:
Journal Article
MeSH Terms:
Peptidomimetics*/chemistry
Peptidomimetics*/pharmacology
Urokinase-Type Plasminogen Activator*/metabolism
Serine Proteinase Inhibitors*/chemistry
Serine Proteinase Inhibitors*/pharmacology
Ligands ; Peptide Hydrolases ; Trypsin ; Serine Endopeptidases
Academic Journal
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Title:
Increased Expression Levels of Thermophilic Serine Protease TTHA0724 through Signal Peptide Screening in Bacillus subtilis and Applications of the Enzyme.
Authors:
Xu Y; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, Changchun 130021, China.
Xuan X; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, Changchun 130021, China.
Gao R; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, Changchun 130021, China.
Xie G; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 03; Vol. 24 (21). Date of Electronic Publication: 2023 Nov 03.
Publication Type:
Journal Article
MeSH Terms:
Bacillus subtilis*/metabolism
Serine Proteases*/metabolism
Protein Sorting Signals ; Escherichia coli/metabolism ; Serine Endopeptidases/metabolism
Academic Journal
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Title:
Proteolytic Activation of the Epithelial Sodium Channel (ENaC): Its Mechanisms and Implications.
Authors:
Aufy M; Division of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna, 1090 Vienna, Austria.
Hussein AM; Division of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna, 1090 Vienna, Austria.; Department of Zoology, Faculty of Science, Al-Azhar University, Assiut 71524, Egypt.
Stojanovic T; Programme for Proteomics, Paracelsus Medical University, 5020 Salzburg, Austria.
Studenik CR; Division of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna, 1090 Vienna, Austria.
Kotob MH; Division of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna, 1090 Vienna, Austria.; Department of Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut 71515, Egypt.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 16; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 16.
Publication Type:
Journal Article; Review
MeSH Terms:
Epithelial Sodium Channels*/metabolism
Serine Endopeptidases*/metabolism
Proteolysis ; Serine Proteases ; Sodium/metabolism
Academic Journal
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Title:
Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies.
Authors:
Nakano S; Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Kashio S; Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Nishimura K; Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Takeishi A; Neural Circuit of Multisensory Integration RIKEN Hakubi Research Team, RIKEN Center for Brain Science, RIKEN Cluster for Pioneering Research, Wako, Japan.
Kosakamoto H; Laboratory for Nutritional Biology, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
Obata F; Laboratory for Nutritional Biology, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.; Laboratory of Molecular Cell Biology and Development, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Kuranaga E; Laboratory of Histogenetic Dynamics, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
Chihara T; Program of Biomedical Science and Program of Basic Biology, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima Japan.
Yamauchi Y; Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Japan.
Isobe T; Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Japan.
Miura M; Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
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Source:
PLoS genetics [PLoS Genet] 2023 Jun 15; Vol. 19 (6), pp. e1010761. Date of Electronic Publication: 2023 Jun 15 (Print Publication: 2023).
Publication Type:
Journal Article
MeSH Terms:
Serine Proteases*/genetics
Serine Proteases*/metabolism
Drosophila Proteins*/metabolism
Animals ; Toll-Like Receptors/genetics ; Toll-Like Receptors/metabolism ; Proteomics ; Reactive Oxygen Species ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Drosophila/metabolism ; Apoptosis/genetics
Academic Journal
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Title:
Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/β-Catenin Signaling.
Authors:
Lama Tamang R; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198-6125, USA.
Kumar B; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198-6125, USA.
Patel SM; Department of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Thapa I; School of Interdisciplinary Informatics, College of Information Science & Technology, University of Nebraska at Omaha, Omaha, NE 68182, USA.
Ahmad A; Department of Pathology and Microbiology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198-6125, USA.
Kumar V; Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198-6125, USA.
Ahmad R; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198-6125, USA.
Becker DF; Department of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Bastola DK; School of Interdisciplinary Informatics, College of Information Science & Technology, University of Nebraska at Omaha, Omaha, NE 68182, USA.
Dhawan P; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198-6125, USA.; Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105-1850, USA.; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198-65870, USA.
Singh AB; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198-6125, USA.; Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105-1850, USA.; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198-65870, USA.
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Cells [Cells] 2023 Jul 18; Vol. 12 (14). Date of Electronic Publication: 2023 Jul 18.
Publication Type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Protein Serine-Threonine Kinases*/metabolism
Colonic Neoplasms*
Humans ; beta Catenin/metabolism ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Carcinogenesis ; Wnt Signaling Pathway/genetics ; Microtubules/metabolism ; Proline ; Oxidoreductases/metabolism ; Serine ; Microtubule-Associated Proteins/metabolism
Academic Journal
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Title:
A putative cytotoxic serine protease from Salmonella typhimurium UcB5 recovered from undercooked burger.
Authors:
Kotb E; Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University (IAU), P.O. Box 1982, Dammam, 31441, Saudi Arabia. .; Basic & Applied Scientific Research Center, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, 31441, Saudi Arabia. .
El-Nogoumy BA; Department of Botany and Microbiology, Faculty of Science, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt.
Alqahtani HA; Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University (IAU), P.O. Box 1982, Dammam, 31441, Saudi Arabia.
Ahmed AA; Department of Statistics, Faculty of Commerce, Al-Azhar University (Girls' Branch), P.O. Box 11751, Cairo, Egypt.
Al-Shwyeh HA; Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University (IAU), P.O. Box 1982, Dammam, 31441, Saudi Arabia.; Basic & Applied Scientific Research Center, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, 31441, Saudi Arabia.
Algarudi SM; Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University (IAU), P.O. Box 1982, Dammam, 31441, Saudi Arabia.; Basic & Applied Scientific Research Center, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, 31441, Saudi Arabia.
Almahasheer H; Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University (IAU), P.O. Box 1982, Dammam, 31441, Saudi Arabia.
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Source:
Scientific reports [Sci Rep] 2023 Mar 09; Vol. 13 (1), pp. 3926. Date of Electronic Publication: 2023 Mar 09.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Serine Proteases*/metabolism
Salmonella typhimurium*/metabolism
Hydrogen-Ion Concentration ; Serine Endopeptidases/metabolism ; Isoelectric Point ; Temperature ; Substrate Specificity ; Molecular Weight
Academic Journal
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Title:
HTRA1 methylation in peripheral blood as a potential marker for the preclinical detection of stroke: a case-control study and a prospective nested case-control study.
Authors:
Liu C; Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning, Nanjing, 211166, China.
Li M; Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning, Nanjing, 211166, China.
Yin Q; Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning, Nanjing, 211166, China.
Fan Y; Division of Clinical Epidemiology, Affiliated Geriatric Hospital of Nanjing Medical University, Nanjing, 211166, China.
Shen C; Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning, Nanjing, 211166, China. .
Yang R; Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning, Nanjing, 211166, China. .
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Source:
Clinical epigenetics [Clin Epigenetics] 2022 Dec 29; Vol. 14 (1), pp. 191. Date of Electronic Publication: 2022 Dec 29.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Serine Endopeptidases*/genetics
Serine Endopeptidases*/metabolism
DNA Methylation*
Humans ; Prospective Studies ; Case-Control Studies ; Biomarkers/metabolism ; High-Temperature Requirement A Serine Peptidase 1/genetics ; High-Temperature Requirement A Serine Peptidase 1/metabolism
Academic Journal
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Title:
Age- and Sex-Dependent Behavioral and Neurochemical Alterations in hLRRK2-G2019S BAC Mice.
Authors:
Yao N; Molecular Neurophysiology Laboratory, Department of Physiology and Pharmacology, Karolinska Institutet, 171 64 Stockholm, Sweden.
Skiteva O; Molecular Neurophysiology Laboratory, Department of Physiology and Pharmacology, Karolinska Institutet, 171 64 Stockholm, Sweden.
Chergui K; Molecular Neurophysiology Laboratory, Department of Physiology and Pharmacology, Karolinska Institutet, 171 64 Stockholm, Sweden.
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Source:
Biomolecules [Biomolecules] 2022 Dec 27; Vol. 13 (1). Date of Electronic Publication: 2022 Dec 27.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Serine-Threonine Kinases*/metabolism
Substantia Nigra*/metabolism
Animals ; Female ; Male ; Mice ; Corpus Striatum/metabolism ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/metabolism ; Mice, Transgenic ; Mutation
Academic Journal
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Title:
Crystal structure of Sphingobacterium multivorum serine palmitoyltransferase complexed with tris(hydroxymethyl)aminomethane.
Authors:
Ikushiro H; Department of Biochemistry, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan.
Takahashi A; Department of Chemistry, Graduate School of Science, Osaka Metropolitan University, Osaka 558-8585, Japan.
Murakami T; Department of Chemistry, Graduate School of Science, Osaka Metropolitan University, Osaka 558-8585, Japan.
Katayama A; Department of Chemistry, Graduate School of Science, Osaka Metropolitan University, Osaka 558-8585, Japan.
Sawai T; Department of Biochemistry, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan.
Goto H; Department of Biochemistry, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan.
Miyahara I; Department of Chemistry, Graduate School of Science, Osaka Metropolitan University, Osaka 558-8585, Japan.
Kamiya N; Research Center for Artificial Photosynthesis, Osaka Metropolitan University, Osaka 558-8585, Japan.
Yano T; Department of Biochemistry, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan.
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Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2022 Dec 01; Vol. 78 (Pt 12), pp. 408-415. Date of Electronic Publication: 2022 Nov 28.
Publication Type:
Journal Article
MeSH Terms:
Serine C-Palmitoyltransferase*
Tromethamine*
Crystallography, X-Ray ; Pyridoxal Phosphate ; Serine
SCR Organism:
Sphingobacterium multivorum
Academic Journal
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Title:
Impaired Mitochondrial Function and Marrow Failure in Patients Carrying a Variant of the SRSF4 Gene.
Authors:
Miano M; Haematology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Bertola N; Molecular Pathology Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Grossi A; Laboratory of Genetics and Genomics of Rare Diseases, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Dell'Orso G; Haematology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Regis S; Laboratory of Clinical and Experimental Immunology, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Rusmini M; Laboratory of Genetics and Genomics of Rare Diseases, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Uva P; Clinical Bioinformatics Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Vozzi D; Genomics Facility, Istituto Italiano di Tecnologia (IIT), 16163 Genoa, Italy.
Fioredda F; Haematology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Palmisani E; Haematology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Lupia M; Haematology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Lanciotti M; Haematology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Grilli F; Haematology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Corsolini F; Laboratory for the Study of Inborn Errors of Metabolism (LABSIEM), Pediatric Clinic and Endocrinology, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Arcuri L; Haematology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Giarratana MC; Haematology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Ceccherini I; Laboratory of Genetics and Genomics of Rare Diseases, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Dufour C; Haematology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Cappelli E; Haematology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Ravera S; Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.
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International journal of molecular sciences [Int J Mol Sci] 2024 Feb 08; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 08.
Publication Type:
Case Reports; Journal Article
MeSH Terms:
Bone Marrow*/metabolism
Bone Marrow*/pathology
Mitochondria*/genetics
Mitochondria*/metabolism
Mitochondria*/pathology
Neutropenia*
Serine-Arginine Splicing Factors*/genetics
Serine-Arginine Splicing Factors*/metabolism
Child ; Humans ; Alternative Splicing ; Mitochondrial Dynamics/genetics ; Mitochondrial Proteins/metabolism ; Phosphoproteins/metabolism ; RNA Precursors/genetics
Academic Journal
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Title:
High expression of serine and arginine-rich splicing factor 9 (SRSF9) is associated with hepatocellular carcinoma progression and a poor prognosis.
Authors:
Zhang G; School of Public Health, North China University of Science and Technology, Tangshan, 063210, Hebei Province, People's Republic of China.; Department of Gastroenterology, Affiliated Hospital of North China University of Technology, Tangshan, 063007, Hebei Province, People's Republic of China.
Liu B; Department of Gastroenterology, Chaisang District People's Hospital, Jiujiang, 332199, Jiangxi Province, People's Republic of China.
Shang H; Blood Purification Department of Tangshan Infectious Disease Hospital, Tangshan, 063026, Hebei Province, People's Republic of China.
Wu G; Department of Gastroenterology, Tangshan Workers' Hospital, Tangshan, 063003, Hebei Province, People's Republic of China.
Wu D; Department of Gastroenterology, Tangshan Workers' Hospital, Tangshan, 063003, Hebei Province, People's Republic of China.
Wang L; Department of Gastroenterology, Hongci Hospital, Tangshan, 063009, Hebei Province, People's Republic of China.
Li S; Department of Gastroenterology, Affiliated Hospital of North China University of Technology, Tangshan, 063007, Hebei Province, People's Republic of China.
Wang Z; Department of Gastroenterology, Affiliated Hospital of North China University of Technology, Tangshan, 063007, Hebei Province, People's Republic of China.
Wang S; Department of Gastroenterology, Affiliated Hospital of North China University of Technology, Tangshan, 063007, Hebei Province, People's Republic of China.
Yuan J; School of Public Health, North China University of Science and Technology, Tangshan, 063210, Hebei Province, People's Republic of China. .
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Source:
BMC medical genomics [BMC Med Genomics] 2022 Aug 15; Vol. 15 (1), pp. 180. Date of Electronic Publication: 2022 Aug 15.
Publication Type:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/diagnosis
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/diagnosis
Liver Neoplasms*/pathology
Serine-Arginine Splicing Factors*/genetics
Carrier Proteins ; Cell Line, Tumor ; Cell Proliferation ; DNA Methylation ; Eukaryotic Initiation Factors/genetics ; Eukaryotic Initiation Factors/metabolism ; Factor IX/genetics ; Factor IX/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Mannose-Binding Protein-Associated Serine Proteases/genetics ; Mannose-Binding Protein-Associated Serine Proteases/metabolism ; Prognosis ; RNA Splicing Factors/genetics ; Retinol-Binding Proteins, Plasma ; Serine/genetics ; Serine/metabolism
Academic Journal
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Title:
The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle.
Authors:
Ryan PJ; Muscle Biology Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, Gilchrist Building, 2929 Research Parkway, College Station, TX, 77843-4243, USA.
Uranga S; Muscle Biology Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, Gilchrist Building, 2929 Research Parkway, College Station, TX, 77843-4243, USA.
Stanelle ST; Muscle Biology Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, Gilchrist Building, 2929 Research Parkway, College Station, TX, 77843-4243, USA.
Lewis MH; Muscle Biology Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, Gilchrist Building, 2929 Research Parkway, College Station, TX, 77843-4243, USA.
O'Reilly CL; Muscle Biology Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, Gilchrist Building, 2929 Research Parkway, College Station, TX, 77843-4243, USA.
Cardin JM; Muscle Biology Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, Gilchrist Building, 2929 Research Parkway, College Station, TX, 77843-4243, USA.
Deaver JW; Muscle Biology Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, Gilchrist Building, 2929 Research Parkway, College Station, TX, 77843-4243, USA.
Morton AB; Soft Tissue Regeneration and Applied Biomaterials Laboratory, Texas A&M University, Gilchrist Building, 2929 Research Parkway, College Station, TX, 77843-4243, USA.
Fluckey JD; Muscle Biology Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, Gilchrist Building, 2929 Research Parkway, College Station, TX, 77843-4243, USA. .
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Scientific reports [Sci Rep] 2024 Apr 06; Vol. 14 (1), pp. 8094. Date of Electronic Publication: 2024 Apr 06.
Publication Type:
Journal Article
MeSH Terms:
TOR Serine-Threonine Kinases*
Autophagy*/physiology
Aminopyridines*
Mechanistic Target of Rapamycin Complex 1/metabolism ; Muscle, Skeletal/metabolism
Academic Journal
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Title:
Complement MASP-1 Modifies Endothelial Wound Healing.
Authors:
Németh Z; Department of Internal Medicine and Haematology, Semmelweis University, 1085 Budapest, Hungary.
Demeter F; Department of Internal Medicine and Haematology, Semmelweis University, 1085 Budapest, Hungary.
Dobó J; Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Hungarian Research Network, 1117 Budapest, Hungary.
Gál P; Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Hungarian Research Network, 1117 Budapest, Hungary.
Cervenak L; Department of Internal Medicine and Haematology, Semmelweis University, 1085 Budapest, Hungary.
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International journal of molecular sciences [Int J Mol Sci] 2024 Apr 05; Vol. 25 (7). Date of Electronic Publication: 2024 Apr 05.
Publication Type:
Journal Article
MeSH Terms:
Endothelial Cells*
Mannose-Binding Protein-Associated Serine Proteases*/genetics
Vascular Cell Adhesion Molecule-1 ; Wound Healing ; Complement System Proteins
Academic Journal
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Title:
Identification and functional activity of Nik related kinase (NRK) in benign hyperplastic prostate.
Authors:
He W; Department of Urology, Xijing Hospital of Air Force Medical University, West Changle Road 127, Xi'an, China. .
Tian Z; Department of Hepatobiliary Surgery, Xijing Hospital of Air Force Medical University, Xi'an, China.
Dong B; Department of Orthopedics, Ninth Hospital of Xi'an, Xi'an, China.
Cao Y; Department of Urology, Xijing Hospital of Air Force Medical University, West Changle Road 127, Xi'an, China.
Hu W; Department of Urology, Xijing Hospital of Air Force Medical University, West Changle Road 127, Xi'an, China.
Wu P; Department of Urology, Xijing Hospital of Air Force Medical University, West Changle Road 127, Xi'an, China.
Yu L; Department of Urology, Xijing Hospital of Air Force Medical University, West Changle Road 127, Xi'an, China.
Zhang X; Department of Urology, Zhongnan Hospital of Wuhan University, Donghu Road 169, Wuhan, China. .
Guo S; Department of Physiology and Pathophysiology, Air Force Medical University, West Changle Road 169, Xi'an, China. .
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Source:
Journal of translational medicine [J Transl Med] 2024 Mar 09; Vol. 22 (1), pp. 255. Date of Electronic Publication: 2024 Mar 09.
Publication Type:
Journal Article
MeSH Terms:
Prostate*/metabolism
Prostatic Hyperplasia*/genetics
Prostatic Hyperplasia*/metabolism
Prostatic Hyperplasia*/pathology
Protein Serine-Threonine Kinases*
Intracellular Signaling Peptides and Proteins*
Male ; Humans ; Aged ; Hyperplasia/metabolism ; Hyperplasia/pathology ; Fibrosis
Academic Journal
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Title:
Indoxyl Sulfate-Induced Valve Endothelial Cell Endothelial-to-Mesenchymal Transition and Calcification in an Integrin-Linked Kinase-Dependent Manner.
Authors:
Delgado-Marin M; Unidad de Fisiología, Departamento de Biología de Sistemas, Facultad de Medicina, IRYCIS, Universidad de Alcalá, 28871 Alcalá de Henares, Spain.
Sánchez-Esteban S; Unidad de Fisiología, Departamento de Biología de Sistemas, Facultad de Medicina, IRYCIS, Universidad de Alcalá, 28871 Alcalá de Henares, Spain.
Cook-Calvete A; Unidad de Fisiología, Departamento de Biología de Sistemas, Facultad de Medicina, IRYCIS, Universidad de Alcalá, 28871 Alcalá de Henares, Spain.
Jorquera-Ortega S; Unidad de Fisiología, Departamento de Biología de Sistemas, Facultad de Medicina, IRYCIS, Universidad de Alcalá, 28871 Alcalá de Henares, Spain.
Zaragoza C; Cardiovascular Research University Francisco de Vitoria and Hospital Ramon y Cajal, IRYCIS, 28034 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Saura M; Unidad de Fisiología, Departamento de Biología de Sistemas, Facultad de Medicina, IRYCIS, Universidad de Alcalá, 28871 Alcalá de Henares, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.
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Source:
Cells [Cells] 2024 Mar 08; Vol. 13 (6). Date of Electronic Publication: 2024 Mar 08.
Publication Type:
Journal Article
MeSH Terms:
Vascular Calcification*/metabolism
Renal Insufficiency, Chronic*/pathology
Aortic Valve Stenosis*
Calcinosis*
Protein Serine-Threonine Kinases*
Aortic Valve/*pathology
Humans ; Indican ; Core Binding Factor Alpha 1 Subunit/metabolism ; Endothelial Cells/metabolism ; Cells, Cultured
SCR Disease Name:
Aortic Valve, Calcification of
Academic Journal
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Title:
The Mitochondrial Connection: The Nek Kinases' New Functional Axis in Mitochondrial Homeostasis.
Authors:
Basei FL; Faculty of Pharmaceutical Sciences, University of Campinas, Campinas 13083-871, Brazil.
E Silva IR; Faculty of Pharmaceutical Sciences, University of Campinas, Campinas 13083-871, Brazil.
Dias PRF; Faculty of Pharmaceutical Sciences, University of Campinas, Campinas 13083-871, Brazil.
Ferezin CC; Faculty of Pharmaceutical Sciences, University of Campinas, Campinas 13083-871, Brazil.
Peres de Oliveira A; Faculty of Pharmaceutical Sciences, University of Campinas, Campinas 13083-871, Brazil.
Issayama LK; Faculty of Pharmaceutical Sciences, University of Campinas, Campinas 13083-871, Brazil.
Moura LAR; Faculty of Pharmaceutical Sciences, University of Campinas, Campinas 13083-871, Brazil.
da Silva FR; Faculty of Pharmaceutical Sciences, University of Campinas, Campinas 13083-871, Brazil.
Kobarg J; Faculty of Pharmaceutical Sciences, University of Campinas, Campinas 13083-871, Brazil.
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Source:
Cells [Cells] 2024 Mar 07; Vol. 13 (6). Date of Electronic Publication: 2024 Mar 07.
Publication Type:
Journal Article; Review
MeSH Terms:
Protein Serine-Threonine Kinases*/metabolism
Mitochondria*/metabolism
NIMA-Related Kinases/metabolism ; Homeostasis ; DNA, Mitochondrial
Academic Journal
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Title:
Pan-cancer analysis reveals PDK family as potential indicators related to prognosis and immune infiltration.
Authors:
Tao S; The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
Tao K; Guiping People's Hospital, Guangxi, China.
Cai X; The Second Affiliated Hospital of Guangxi Medical University, Nanning, China. .
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Source:
Scientific reports [Sci Rep] 2024 Mar 07; Vol. 14 (1), pp. 5665. Date of Electronic Publication: 2024 Mar 07.
Publication Type:
Journal Article
MeSH Terms:
Protein Serine-Threonine Kinases*/metabolism
Neoplasms*/metabolism
Humans ; Pyruvate Dehydrogenase Acetyl-Transferring Kinase/genetics ; Prognosis ; Pyruvates ; Pyruvate Dehydrogenase Complex/metabolism
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Title:
Emerging Role of GCN1 in Disease and Homeostasis.
Authors:
Tatara Y; Department of Stress Response Science, Biomedical Research Center, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Aomori, Japan.
Kasai S; Department of Stress Response Science, Biomedical Research Center, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Aomori, Japan.
Kokubu D; Diet and Well-Being Research Institute, KAGOME, Co., Ltd., 17 Nishitomiyama, Nasushiobara 329-2762, Tochigi, Japan.; Department of Vegetable Life Science, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Aomori, Japan.
Tsujita T; Laboratory of Biochemistry, Department of Applied Biochemistry and Food Science, Faculty of Agriculture, Saga University, 1 Honjo-machi, Saga City 840-8502, Saga, Japan.
Mimura J; Department of Stress Response Science, Biomedical Research Center, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Aomori, Japan.
Itoh K; Department of Stress Response Science, Biomedical Research Center, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Aomori, Japan.; Department of Vegetable Life Science, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Aomori, Japan.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 05; Vol. 25 (5). Date of Electronic Publication: 2024 Mar 05.
Publication Type:
Journal Article; Review
MeSH Terms:
Protein Serine-Threonine Kinases*/metabolism
Animals ; Humans ; Mice ; Amino Acids/metabolism ; Homeostasis ; Peptide Elongation Factors/metabolism ; RNA-Binding Proteins/metabolism ; Trans-Activators/metabolism
Academic Journal
Full Text  Link opens in a new window Full TextDetails
Showing 1-20 from 84724 results

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