Temat: "SERINE" - OpacWWW - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Bcl-3 regulates T cell function through energy metabolism.
Autorzy:: Liu H; Henan Key Laboratory of Immunology and Targeted Drug, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.
Zeng L; Henan Key Laboratory of Immunology and Targeted Drug, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.
Pan M; Henan Key Laboratory of Immunology and Targeted Drug, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.
Huang L; Henan Key Laboratory of Immunology and Targeted Drug, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.
Li H; Henan Key Laboratory of Immunology and Targeted Drug, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.
Liu M; Henan Key Laboratory of Immunology and Targeted Drug, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.
Niu X; Henan Key Laboratory of Immunology and Targeted Drug, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.
Zhang C; Henan Key Laboratory of Immunology and Targeted Drug, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China.
Wang H; Henan Key Laboratory of Immunology and Targeted Drug, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China. .; Pokaż więcej
Źródło:: BMC immunology [BMC Immunol] 2023 Oct 04; Vol. 24 (1), pp. 35. Date of Electronic Publication: 2023 Oct 04.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Apoptosis*
NF-kappa B*/metabolism
B-Cell Lymphoma 3 Protein*/metabolism
T-Lymphocytes*/metabolism
Humans ; Cell Survival ; Energy Metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 2.

Tytuł:: The Many Faces of MLKL, the Executor of Necroptosis.
Autorzy:: Martinez-Osorio V; Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.
Abdelwahab Y; Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.
Ros U; Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Jun 14; Vol. 24 (12). Date of Electronic Publication: 2023 Jun 14.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Apoptosis*/physiology
Protein Kinases*/metabolism
Humans ; Necroptosis ; Cell Death ; Cell Membrane/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 3.

Tytuł:: Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
Autorzy:: Ehrmann JF; Research Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.; Vienna BioCenter PhD Program, Doctoral School of the University of Vienna and Medical University of Vienna, Vienna BioCenter, Vienna, Austria.
Grabarczyk DB; Research Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.
Heinke M; Research Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.
Deszcz L; Research Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.
Kurzbauer R; Research Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.
Hudecz O; Research Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.
Shulkina A; Vienna BioCenter PhD Program, Doctoral School of the University of Vienna and Medical University of Vienna, Vienna BioCenter, Vienna, Austria.; Max Perutz Labs, University of Vienna, Vienna BioCenter, Vienna, Austria.
Gogova R; Research Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.; Vienna BioCenter PhD Program, Doctoral School of the University of Vienna and Medical University of Vienna, Vienna BioCenter, Vienna, Austria.
Meinhart A; Research Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.
Versteeg GA; Max Perutz Labs, University of Vienna, Vienna BioCenter, Vienna, Austria.
Clausen T; Research Institute of Molecular Pathology, Vienna BioCenter, Vienna, Austria.; Medical University of Vienna, Vienna, Austria.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Mar 17; Vol. 379 (6637), pp. 1117-1123. Date of Electronic Publication: 2023 Feb 09.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*/physiology
Apoptosis Regulatory Proteins*/chemistry
Apoptosis Regulatory Proteins*/metabolism
Inhibitor of Apoptosis Proteins*/chemistry
Inhibitor of Apoptosis Proteins*/metabolism
Mitochondrial Proteins*/chemistry
Mitochondrial Proteins*/metabolism
Humans ; Autophagy ; Cryoelectron Microscopy ; Ubiquitination ; Protein Multimerization ; High-Temperature Requirement A Serine Peptidase 2/chemistry ; High-Temperature Requirement A Serine Peptidase 2/metabolism

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 4.

Tytuł:: Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.
Autorzy:: Hunkeler M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Jin CY; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Mar 17; Vol. 379 (6637), pp. 1105-1111. Date of Electronic Publication: 2023 Feb 09.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*
Caspases*/chemistry
Caspases*/metabolism
Inhibitor of Apoptosis Proteins*/chemistry
Inhibitor of Apoptosis Proteins*/metabolism
Mitochondrial Proteins*/chemistry
Mitochondrial Proteins*/metabolism
Apoptosis Regulatory Proteins*/chemistry
Apoptosis Regulatory Proteins*/metabolism
Animals ; Humans ; Cryoelectron Microscopy ; Enzyme Activation ; High-Temperature Requirement A Serine Peptidase 2/chemistry ; High-Temperature Requirement A Serine Peptidase 2/metabolism ; Protein Domains

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 5.

Tytuł:: Tenofovir disoproxil fumarate directly ameliorates liver fibrosis by inducing hepatic stellate cell apoptosis via downregulation of PI3K/Akt/mTOR signaling pathway.
Autorzy:: Lee SW; Department of Biomedicine & Health Sciences, The Catholic University Liver Research Centre, POSTECH-Catholic Biomedical Engineering Institute, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Kim SM; Department of Biomedicine & Health Sciences, The Catholic University Liver Research Centre, POSTECH-Catholic Biomedical Engineering Institute, The Catholic University of Korea, Seoul, Republic of Korea.
Hur W; Department of Biomedicine & Health Sciences, The Catholic University Liver Research Centre, POSTECH-Catholic Biomedical Engineering Institute, The Catholic University of Korea, Seoul, Republic of Korea.
Kang BY; Department of Biomedicine & Health Sciences, The Catholic University Liver Research Centre, POSTECH-Catholic Biomedical Engineering Institute, The Catholic University of Korea, Seoul, Republic of Korea.
Lee HL; Department of Biomedicine & Health Sciences, The Catholic University Liver Research Centre, POSTECH-Catholic Biomedical Engineering Institute, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Nam H; Department of Biomedicine & Health Sciences, The Catholic University Liver Research Centre, POSTECH-Catholic Biomedical Engineering Institute, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Yoo SH; Department of Biomedicine & Health Sciences, The Catholic University Liver Research Centre, POSTECH-Catholic Biomedical Engineering Institute, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Sung PS; Department of Biomedicine & Health Sciences, The Catholic University Liver Research Centre, POSTECH-Catholic Biomedical Engineering Institute, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Kwon JH; Department of Biomedicine & Health Sciences, The Catholic University Liver Research Centre, POSTECH-Catholic Biomedical Engineering Institute, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Jang JW; Department of Biomedicine & Health Sciences, The Catholic University Liver Research Centre, POSTECH-Catholic Biomedical Engineering Institute, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Kim SJ; Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Yoon SK; Department of Biomedicine & Health Sciences, The Catholic University Liver Research Centre, POSTECH-Catholic Biomedical Engineering Institute, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2021 Dec 08; Vol. 16 (12), pp. e0261067. Date of Electronic Publication: 2021 Dec 08 (Print Publication: 2021).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Apoptosis*
Gene Expression Regulation/*drug effects
Hepatic Stellate Cells/*drug effects
Liver Cirrhosis/*drug therapy
Phosphatidylinositol 3-Kinases/*chemistry
Proto-Oncogene Proteins c-akt/*antagonists & inhibitors
TOR Serine-Threonine Kinases/*antagonists & inhibitors
Tenofovir/*pharmacology
Animals ; Antiviral Agents/pharmacology ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Humans ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Thioacetamide/toxicity

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 6.

Tytuł:: Inhibition of VDAC1 prevents oxidative stress and apoptosis induced by bisphenol A in spermatogonia via AMPK/mTOR signaling pathway.
Autorzy:: Wang H; Department of Obstetrics and Gynecology, the First Affiliated Hospital of The Fourth Military Medical University, China.
Li Y; Department of Obstetrics and Gynecology, the First Affiliated Hospital of The Fourth Military Medical University, China.
Liu C; Department of Obstetrics and Gynecology, the First Affiliated Hospital of The Fourth Military Medical University, China.
Lu T; Department of Obstetrics and Gynecology, the First Affiliated Hospital of The Fourth Military Medical University, China.
Zhai Q; Department of Obstetrics and Gynecology, the First Affiliated Hospital of The Fourth Military Medical University, China.
Wang H; Department of Obstetrics and Gynecology, the First Affiliated Hospital of The Fourth Military Medical University, China.
Zhang J; Department of Obstetrics and Gynecology, the First Affiliated Hospital of The Fourth Military Medical University, China.; Pokaż więcej
Źródło:: The Journal of toxicological sciences [J Toxicol Sci] 2023; Vol. 48 (3), pp. 109-119.
Typ publikacji:: Journal Article
MeSH Terms:: AMP-Activated Protein Kinases*
Apoptosis*
Oxidative Stress*
Spermatogonia*/drug effects
Voltage-Dependent Anion Channel 1*
Male ; Reactive Oxygen Species ; Signal Transduction ; TOR Serine-Threonine Kinases ; Animals ; Mice

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 7.

Tytuł:: RIPK1 and TRADD Regulate TNF-Induced Signaling and Ripoptosome Formation.
Autorzy:: Feoktistova M; Department of Dermatology and Allergology, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
Makarov R; Department of Dermatology and Allergology, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
Yazdi AS; Department of Dermatology and Allergology, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
Panayotova-Dimitrova D; Department of Dermatology and Allergology, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 18; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 18.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis/*genetics
Necroptosis/*genetics
Receptor-Interacting Protein Serine-Threonine Kinases/*genetics
TNF Receptor-Associated Death Domain Protein/*genetics
Tumor Necrosis Factor-alpha/*metabolism
Apoptosis/drug effects ; Baculoviral IAP Repeat-Containing 3 Protein/genetics ; Baculoviral IAP Repeat-Containing 3 Protein/metabolism ; CASP8 and FADD-Like Apoptosis Regulating Protein/genetics ; CASP8 and FADD-Like Apoptosis Regulating Protein/metabolism ; CRISPR-Cas Systems ; Cycloheximide/pharmacology ; Gene Deletion ; Gene Expression Regulation ; HeLa Cells ; Humans ; I-kappa B Kinase/genetics ; I-kappa B Kinase/metabolism ; Inhibitor of Apoptosis Proteins/genetics ; Inhibitor of Apoptosis Proteins/metabolism ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Necroptosis/drug effects ; Proteasome Endopeptidase Complex/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/deficiency ; Signal Transduction ; TNF Receptor-Associated Death Domain Protein/deficiency ; TNF Receptor-Associated Factor 2/genetics ; TNF Receptor-Associated Factor 2/metabolism ; Tumor Necrosis Factor-alpha/pharmacology ; Ubiquitination

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 8.

Tytuł:: Chrysin Induces Apoptosis via the MAPK Pathway and Regulates ERK/mTOR-Mediated Autophagy in MC-3 Cells.
Autorzy:: Jung GH; Department of Companion and Laboratory Animal Science, Kongju National University, Daehak-ro, Yesan-gun 32439, Chungcheongnam-do, Republic of Korea.
Lee JH; Department of Companion and Laboratory Animal Science, Kongju National University, Daehak-ro, Yesan-gun 32439, Chungcheongnam-do, Republic of Korea.
Han SH; Department of Companion and Laboratory Animal Science, Kongju National University, Daehak-ro, Yesan-gun 32439, Chungcheongnam-do, Republic of Korea.
Woo JS; Department of Companion and Laboratory Animal Science, Kongju National University, Daehak-ro, Yesan-gun 32439, Chungcheongnam-do, Republic of Korea.
Choi EY; Department of Companion and Laboratory Animal Science, Kongju National University, Daehak-ro, Yesan-gun 32439, Chungcheongnam-do, Republic of Korea.
Jeon SJ; Department of Companion and Laboratory Animal Science, Kongju National University, Daehak-ro, Yesan-gun 32439, Chungcheongnam-do, Republic of Korea.
Han EJ; Department of Companion and Laboratory Animal Science, Kongju National University, Daehak-ro, Yesan-gun 32439, Chungcheongnam-do, Republic of Korea.
Jung SH; Department of Companion and Laboratory Animal Science, Kongju National University, Daehak-ro, Yesan-gun 32439, Chungcheongnam-do, Republic of Korea.
Park YS; Department of Companion and Laboratory Animal Science, Kongju National University, Daehak-ro, Yesan-gun 32439, Chungcheongnam-do, Republic of Korea.
Park BK; Department of Companion and Laboratory Animal Science, Kongju National University, Daehak-ro, Yesan-gun 32439, Chungcheongnam-do, Republic of Korea.
Kim BS; Department of Companion and Laboratory Animal Science, Kongju National University, Daehak-ro, Yesan-gun 32439, Chungcheongnam-do, Republic of Korea.
Kim SK; Department of Companion and Laboratory Animal Science, Kongju National University, Daehak-ro, Yesan-gun 32439, Chungcheongnam-do, Republic of Korea.
Jung JY; Department of Companion and Laboratory Animal Science, Kongju National University, Daehak-ro, Yesan-gun 32439, Chungcheongnam-do, Republic of Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Dec 12; Vol. 23 (24). Date of Electronic Publication: 2022 Dec 12.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*
Mouth Neoplasms*/drug therapy
Humans ; TOR Serine-Threonine Kinases/metabolism ; Flavonoids/pharmacology ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Autophagy ; Cell Line, Tumor

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 9.

Tytuł:: Inhibition of the p‑SPAK/p‑NKCC1 signaling pathway protects the blood‑brain barrier and reduces neuronal apoptosis in a rat model of surgical brain injury.
Autorzy:: Gong Y; Department of Rehabilitation, Zhangjiagang Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu 215600, P.R. China.
Wu M; Department of Rehabilitation, Zhangjiagang Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu 215600, P.R. China.
Gao F; Department of Rehabilitation, Zhangjiagang Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu 215600, P.R. China.
Shi M; Department of Anesthesiology, Zhangjiagang Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu 215600, P.R. China.
Gu H; Department of Neurology, Zhangjiagang Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu 215600, P.R. China.
Gao R; Department of Neurosurgery, Zhangjiagang Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu 215600, P.R. China.
Dang BQ; Department of Rehabilitation, Zhangjiagang Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu 215600, P.R. China.
Chen G; Brain and Nerve Research Laboratory, Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2021 Oct; Vol. 24 (4). Date of Electronic Publication: 2021 Aug 13.
Typ publikacji:: Journal Article
MeSH Terms:: Blood-Brain Barrier*
Apoptosis/*drug effects
Brain Injuries/*metabolism
Protective Agents/*pharmacology
Protein Serine-Threonine Kinases/*metabolism
Signal Transduction/*drug effects
Solute Carrier Family 12, Member 2/*metabolism
Animals ; Brain ; Brain Edema/metabolism ; Disease Models, Animal ; Male ; Protein Serine-Threonine Kinases/genetics ; Rats ; Rats, Sprague-Dawley ; Solute Carrier Family 12, Member 2/genetics

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 10.

Tytuł:: Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway.
Autorzy:: Seo HY; Department of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, Korea.
Lee SH; Department of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, Korea.
Lee JH; Department of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, Korea.
Lee JH; Department of Anatomy, Keimyung University School of Medicine, Dageu 42601, Korea.
Jang BK; Department of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, Korea.
Kim MK; Department of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Sep 29; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 29.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis/*drug effects
Carcinoma, Hepatocellular/*metabolism
Diterpenes/*pharmacology
Liver Neoplasms/*metabolism
STAT3 Transcription Factor/*metabolism
Signal Transduction/*drug effects
TOR Serine-Threonine Kinases/*metabolism
src-Family Kinases/*metabolism
Animals ; Apoptosis/genetics ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Phosphorylation/drug effects ; RNA-Seq/methods ; STAT3 Transcription Factor/genetics ; Signal Transduction/genetics ; Survival Analysis ; TOR Serine-Threonine Kinases/genetics ; src-Family Kinases/genetics

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 11.

Tytuł:: Pan-cancer analysis of cuproptosis regulation patterns and identification of mTOR-target responder in clear cell renal cell carcinoma.
Autorzy:: Long S; Institute of Molecular Precision Medicine and Hunan Key Laboratory of Molecular Precision Medicine, Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wang Y; Institute of Molecular Precision Medicine and Hunan Key Laboratory of Molecular Precision Medicine, Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chen Y; Institute of Molecular Precision Medicine and Hunan Key Laboratory of Molecular Precision Medicine, Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Fang T; Institute of Molecular Precision Medicine and Hunan Key Laboratory of Molecular Precision Medicine, Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yao Y; Institute of Molecular Precision Medicine and Hunan Key Laboratory of Molecular Precision Medicine, Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Fu K; Institute of Molecular Precision Medicine and Hunan Key Laboratory of Molecular Precision Medicine, Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China. fu_.; Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China. fu_.; Hunan Key Laboratory of Animal Models for Human Diseases, Central South University, Changsha, Hunan, China. fu_.; National Clinical Research Center for Geriatric Disorders, Changsha, Hunan, China. fu_.; Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, Hunan, China. fu_.; Pokaż więcej
Źródło:: Biology direct [Biol Direct] 2022 Oct 08; Vol. 17 (1), pp. 28. Date of Electronic Publication: 2022 Oct 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Carcinoma, Renal Cell*/genetics
Kidney Neoplasms*/genetics
Apoptosis*
Humans ; Biomarkers, Tumor/analysis ; Copper ; Everolimus/therapeutic use ; TOR Serine-Threonine Kinases

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 12.

Tytuł:: Oridonin Promotes Apoptosis and Restrains the Viability and Migration of Bladder Cancer by Impeding TRPM7 Expression via the ERK and AKT Signaling Pathways.
Autorzy:: Che X; Department of Urology, The Second Affiliated Hospital of Hainan Medical University, 570311 Hainan, China.
Zhan J; Department of Urology, The Second Affiliated Hospital of Hainan Medical University, 570311 Hainan, China.
Zhao F; Department of Urology, The Second Affiliated Hospital of Hainan Medical University, 570311 Hainan, China.
Zhong Z; Department of Urology, The Second Affiliated Hospital of Hainan Medical University, 570311 Hainan, China.
Chen M; Department of Urology, The Second Affiliated Hospital of Hainan Medical University, 570311 Hainan, China.
Han R; Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, 300211 Tianjin, China.
Wang Y; Department of Urology, The Second Affiliated Hospital of Hainan Medical University, 570311 Hainan, China.; Pokaż więcej
Źródło:: BioMed research international [Biomed Res Int] 2021 Jul 05; Vol. 2021, pp. 4340950. Date of Electronic Publication: 2021 Jul 05 (Print Publication: 2021).
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*/drug effects
Apoptosis*/genetics
Cell Movement*/drug effects
Cell Movement*/genetics
MAP Kinase Signaling System*/drug effects
MAP Kinase Signaling System*/genetics
Diterpenes, Kaurane/*pharmacology
Protein Serine-Threonine Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
TRPM Cation Channels/*metabolism
Urinary Bladder Neoplasms/*pathology
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Female ; Humans ; Mice, Inbred C57BL ; Protein Serine-Threonine Kinases/genetics ; TRPM Cation Channels/genetics ; Tumor Stem Cell Assay ; Urinary Bladder Neoplasms/genetics ; Xenograft Model Antitumor Assays ; Mice

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 13.

Tytuł:: circSAMD4A participates in the apoptosis and autophagy of dopaminergic neurons via the miR‑29c‑3p‑mediated AMPK/mTOR pathway in Parkinson's disease.
Autorzy:: Wang W; Department of Neurology, Ningbo No. 6 Hospital, Ningbo, Zhejiang 315040, P.R. China.
Lv R; Department of Neurology, Ningbo No. 6 Hospital, Ningbo, Zhejiang 315040, P.R. China.
Zhang J; Department of Neurology, Ningbo No. 6 Hospital, Ningbo, Zhejiang 315040, P.R. China.
Liu Y; Department of Neurology, Ningbo No. 6 Hospital, Ningbo, Zhejiang 315040, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2021 Jul; Vol. 24 (1). Date of Electronic Publication: 2021 Jun 03.
Typ publikacji:: Journal Article
MeSH Terms:: AMP-Activated Protein Kinases/*metabolism
Apoptosis/*drug effects
Autophagy/*drug effects
Dopaminergic Neurons/*metabolism
MicroRNAs/*metabolism
Parkinson Disease/*metabolism
Repressor Proteins/*metabolism
TOR Serine-Threonine Kinases/*metabolism
1-Methyl-4-phenylpyridinium/pharmacology ; AMP-Activated Protein Kinases/genetics ; Animals ; Apoptosis/genetics ; Autophagy/genetics ; Cell Line, Tumor ; Disease Models, Animal ; Down-Regulation ; Gene Knockdown Techniques ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Parkinson Disease/genetics ; Repressor Proteins/genetics ; Repressor Proteins/pharmacology ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; Transcriptome

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 14.

Tytuł:: Role of inflammasomes/pyroptosis and PANoptosis during fungal infection.
Autorzy:: Briard B; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Malireddi RKS; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Kanneganti TD; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2021 Mar 18; Vol. 17 (3), pp. e1009358. Date of Electronic Publication: 2021 Mar 18 (Print Publication: 2021).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Apoptosis/*physiology
Inflammasomes/*metabolism
Mycoses/*immunology
Pyroptosis/*immunology
Receptor-Interacting Protein Serine-Threonine Kinases/*metabolism
Animals ; Humans ; Inflammasomes/immunology ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/immunology

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 15.

Tytuł:: MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways.
Autorzy:: Liu Z; Department of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
Ma T; Department of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
Duan J; Department of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
Liu X; Department of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
Liu L; Department of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2021 Feb; Vol. 23 (2). Date of Electronic Publication: 2020 Dec 23.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*
Cell Proliferation*
Signal Transduction*
F-Box-WD Repeat-Containing Protein 7/*metabolism
MicroRNAs/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
RNA, Neoplasm/*metabolism
Receptors, Notch/*metabolism
TOR Serine-Threonine Kinases/*metabolism
F-Box-WD Repeat-Containing Protein 7/genetics ; Female ; HCT116 Cells ; Humans ; Male ; MicroRNAs/genetics ; Proto-Oncogene Proteins c-akt/genetics ; RNA, Neoplasm/genetics ; Receptors, Notch/genetics ; TOR Serine-Threonine Kinases/genetics

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 16.

Tytuł:: eIF4A1 Inhibitor Suppresses Hyperactive mTOR-Associated Tumors by Inducing Necroptosis and G2/M Arrest.
Autorzy:: Han L; State Key Laboratory of Medical Molecular Biology, Department of Physiology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China.
Wu Y; State Key Laboratory of Medical Molecular Biology, Department of Physiology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China.
Liu F; State Key Laboratory of Medical Molecular Biology, Department of Physiology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China.
Zhang H; State Key Laboratory of Medical Molecular Biology, Department of Physiology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Jun 22; Vol. 23 (13). Date of Electronic Publication: 2022 Jun 22.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*
Necroptosis*
Cell Line, Tumor ; G2 Phase Cell Cycle Checkpoints ; Sirolimus ; TOR Serine-Threonine Kinases/metabolism ; Tuberous Sclerosis
SCR Disease Name:: Tuberous Sclerosis 2

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 17.

Tytuł:: Fish oil-derived lipid emulsion induces RIP1-dependent and caspase 8-licensed necroptosis in IEC-6 cells through overproduction of reactive oxygen species.
Autorzy:: Yan JK; Department of Pediatric Surgery, Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai Institute for Pediatric Research, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Rd, Shanghai, 200092, China.
Yan WH; Department of Pediatric Surgery, Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. .; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai Institute for Pediatric Research, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Rd, Shanghai, 200092, China. .
Cai W; Department of Pediatric Surgery, Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. .; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai Institute for Pediatric Research, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Rd, Shanghai, 200092, China. .; Pokaż więcej
Źródło:: Lipids in health and disease [Lipids Health Dis] 2018 Jun 23; Vol. 17 (1), pp. 148. Date of Electronic Publication: 2018 Jun 23.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis/*drug effects
Caspase 8/*genetics
Epithelial Cells/*drug effects
Fish Oils/*pharmacology
Protein Serine-Threonine Kinases/*genetics
Reactive Oxygen Species/*agonists
Acrylamides/pharmacology ; Animals ; Apoptosis/genetics ; Caspase 8/metabolism ; Cell Line ; Cell Survival/drug effects ; Emulsions ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Fish Oils/chemistry ; Gene Expression Regulation ; Humans ; Imidazoles/pharmacology ; Indoles/pharmacology ; Intestine, Small/cytology ; Intestine, Small/metabolism ; Necrosis/chemically induced ; Necrosis/genetics ; Necrosis/pathology ; Necrosis/prevention & control ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein Serine-Threonine Kinases/metabolism ; Rats ; Reactive Oxygen Species/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/genetics ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Signal Transduction ; Sulfonamides/pharmacology ; Time-Lapse Imaging

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 18.

Tytuł:: TMPRSS13 promotes cell survival, invasion, and resistance to drug-induced apoptosis in colorectal cancer.
Autorzy:: Varela FA; Department of Pharmacology, Wayne State University School of Medicine, Detroit, 48201, MI, USA.
Foust VL; Department of Pharmacology, Wayne State University School of Medicine, Detroit, 48201, MI, USA.
Hyland TE; Department of Pharmacology, Wayne State University School of Medicine, Detroit, 48201, MI, USA.
Sala-Hamrick KE; Department of Pharmacology, Wayne State University School of Medicine, Detroit, 48201, MI, USA.
Mackinder JR; Department of Pharmacology, Wayne State University School of Medicine, Detroit, 48201, MI, USA.
Martin CE; Department of Pharmacology, Wayne State University School of Medicine, Detroit, 48201, MI, USA.; Department of Oncology, Wayne State University School of Medicine, Detroit, 48201, MI, USA.
Murray AS; Department of Pharmacology, Wayne State University School of Medicine, Detroit, 48201, MI, USA.; Department of Oncology, Wayne State University School of Medicine, Detroit, 48201, MI, USA.
Todi SV; Department of Pharmacology, Wayne State University School of Medicine, Detroit, 48201, MI, USA.; Department of Neurology, Wayne State University School of Medicine, Detroit, 48201, MI, USA.
List K; Department of Pharmacology, Wayne State University School of Medicine, Detroit, 48201, MI, USA. .; Department of Oncology, Wayne State University School of Medicine, Detroit, 48201, MI, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Aug 17; Vol. 10 (1), pp. 13896. Date of Electronic Publication: 2020 Aug 17.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Apoptosis*
Antineoplastic Agents/*pharmacology
Colorectal Neoplasms/*pathology
Drug Resistance, Neoplasm/*drug effects
Membrane Proteins/*metabolism
Serine Endopeptidases/*metabolism
Cell Line, Tumor ; Cell Survival/drug effects ; Colorectal Neoplasms/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Silencing/drug effects ; Humans ; Membrane Proteins/genetics ; Neoplasm Invasiveness ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Serine Endopeptidases/genetics ; Up-Regulation/drug effects ; Up-Regulation/genetics

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 19.

Tytuł:: Dying cells fan the flames of inflammation.
Autorzy:: Newton K; Physiological Chemistry Department, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
Dixit VM; Physiological Chemistry Department, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
Kayagaki N; Physiological Chemistry Department, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2021 Nov 26; Vol. 374 (6571), pp. 1076-1080. Date of Electronic Publication: 2021 Nov 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Apoptosis*
Necroptosis*
Pyroptosis*
Inflammation/*physiopathology
Animals ; Caspase 8/metabolism ; Cell Adhesion Molecules, Neuronal/antagonists & inhibitors ; Cell Adhesion Molecules, Neuronal/metabolism ; Fas-Associated Death Domain Protein/metabolism ; Humans ; Inflammasomes/metabolism ; Inflammation/drug therapy ; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors ; Intracellular Signaling Peptides and Proteins/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Nerve Growth Factors/antagonists & inhibitors ; Nerve Growth Factors/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/deficiency ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 20.

Tytuł:: Effects of Escin on Oxidative Stress and Apoptosis of H9c2 Cells Induced by H 2 O 2 .
Autorzy:: Qiao P; Department of Traditional Chinese Medicine, Yantaishan Hospital, Yantai, China.
Zhang B; Public Health, The University of Sheffield, UK.
Liu X; Critical Care Medicine, PLA Rocket Force Characteristic Medical Center, Beijing, China.
Xu J; Department of Medical Security Center, PLA Rocket Force Characteristic Medical Center, Beijing, China.
Li X; Department of Geriatric, Liaocheng People's Hospital, Liaocheng, China.; Pokaż więcej
Źródło:: Disease markers [Dis Markers] 2022 Jan 27; Vol. 2022, pp. 7765353. Date of Electronic Publication: 2022 Jan 27 (Print Publication: 2022).
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis/*drug effects
Cardiovascular Agents/*pharmacology
Escin/*pharmacology
Hydrogen Peroxide/*pharmacology
Inflammation/*drug therapy
Myocytes, Cardiac/*drug effects
Oxidants/*pharmacology
Oxidative Stress/*drug effects
Cells, Cultured ; Humans ; Protein Serine-Threonine Kinases/drug effects ; Signal Transduction/drug effects ; NF-kappaB-Inducing Kinase

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Informacja

Wyszukujesz frazę ""SERINE"" wg kryterium: Temat

Źródło danych

Ogranicz do:

Ogranicz do bazy

Typ dokumentu

Temat

Wydawca

Publikacja

Język