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Wyszukujesz frazę ""SH2 domain"" wg kryterium: Temat


Tytuł :
Druggable cancer phosphatases.
Autorzy :
Vainonen JP; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
Momeny M; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
Westermarck J; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland. .; Institute of Biomedicine, University of Turku, 20520 Turku, Finland.
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Źródło :
Science translational medicine [Sci Transl Med] 2021 Apr 07; Vol. 13 (588).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Neoplasms*/drug therapy
Neoplasms*/genetics
Protein Phosphatase 2*/metabolism
SH2 Domain-Containing Protein Tyrosine Phosphatases*/metabolism
Genes, Tumor Suppressor ; Humans ; Phosphorylation
Czasopismo naukowe
Tytuł :
SH2 domain-containing protein tyrosine phosphatase-2 (SHP-2) prevents cardiac remodeling after myocardial infarction through ERK/SMAD signaling pathway.
Autorzy :
Lu YG; Department of Clinical Laboratory, Hebei General Hospital, No. 348, Heping Road, Xinhua District, Shijiazhuang, 050051, China.
Tan H; Department of Clinical Laboratory, Hebei General Hospital, No. 348, Heping Road, Xinhua District, Shijiazhuang, 050051, China.
Ma Q; Department of Clinical Laboratory, Hebei General Hospital, No. 348, Heping Road, Xinhua District, Shijiazhuang, 050051, China.
Li XX; Department of Clinical Laboratory, Hebei General Hospital, No. 348, Heping Road, Xinhua District, Shijiazhuang, 050051, China.
Cui J; Department of Clinical Laboratory, Hebei General Hospital, No. 348, Heping Road, Xinhua District, Shijiazhuang, 050051, China.
Zhang X; Department of Clinical Laboratory, Hebei North University, Zhangjiakou, China.
Liang XL; Department of Clinical Laboratory, Hebei North University, Zhangjiakou, China.
Tie YQ; Department of Clinical Laboratory, Hebei General Hospital, No. 348, Heping Road, Xinhua District, Shijiazhuang, 050051, China. .
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Źródło :
Human cell [Hum Cell] 2021 Mar; Vol. 34 (2), pp. 325-334. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article
MeSH Terms :
MAP Kinase Signaling System/*drug effects
Myocardial Infarction/*genetics
Myocardial Infarction/*pathology
SH2 Domain-Containing Protein Tyrosine Phosphatases/*pharmacology
Signal Transduction/*drug effects
Signal Transduction/*genetics
Smad2 Protein/*metabolism
Smad3 Protein/*metabolism
Ventricular Remodeling/*drug effects
Animals ; Disease Models, Animal ; Fibrosis/genetics ; MAP Kinase Signaling System/genetics ; Mice, Inbred C57BL ; Myocardium/pathology ; SH2 Domain-Containing Protein Tyrosine Phosphatases/administration & dosage
Czasopismo naukowe
Tytuł :
Determination of the molecular reach of the protein tyrosine phosphatase SHP-1.
Autorzy :
Clemens L; Center for Complex Biological Systems, University of California Irvine, Irvine, California.
Kutuzov M; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
Bayer KV; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
Goyette J; EMBL Australia Node in Single Molecule Science, School of Medical Sciences University of New South Wales, Sydney, Australia; ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, Sydney, Australia.
Allard J; Center for Complex Biological Systems, University of California Irvine, Irvine, California. Electronic address: .
Dushek O; Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2021 May 18; Vol. 120 (10), pp. 2054-2066. Date of Electronic Publication: 2021 Mar 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Protein Tyrosine Phosphatase, Non-Receptor Type 11*
Tyrosine*/metabolism
Phosphorylation ; Protein Phosphatase 1 ; Protein Tyrosine Phosphatase, Non-Receptor Type 6/metabolism ; SH2 Domain-Containing Protein Tyrosine Phosphatases
Czasopismo naukowe
Tytuł :
Overriding Adaptive Resistance to Sorafenib Through Combination Therapy With Src Homology 2 Domain-Containing Phosphatase 2 Blockade in Hepatocellular Carcinoma.
Autorzy :
Leung CON; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.
Tong M; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Chung KPS; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.
Zhou L; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Che N; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Tang KH; Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, NYU Langone Health, New York, NY.
Ding J; The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Lau EYT; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong.
Ng IOL; Department of Pathology, The University of Hong Kong, Hong Kong.; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong.
Ma S; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong.
Lee TKW; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.; State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong.
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Źródło :
Hepatology (Baltimore, Md.) [Hepatology] 2020 Jul; Vol. 72 (1), pp. 155-168. Date of Electronic Publication: 2020 Mar 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*administration & dosage
Carcinoma, Hepatocellular/*drug therapy
Drug Resistance, Neoplasm/*drug effects
Liver Neoplasms/*drug therapy
Piperidines/*administration & dosage
Pyrimidines/*administration & dosage
SH2 Domain-Containing Protein Tyrosine Phosphatases/*antagonists & inhibitors
Sorafenib/*administration & dosage
Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Drug Combinations ; Humans ; Piperidines/pharmacology ; Pyrimidines/pharmacology ; Receptor Protein-Tyrosine Kinases/physiology ; Sorafenib/pharmacology
Czasopismo naukowe
Tytuł :
Siglec-G Deficiency Ameliorates Hyper-Inflammation and Immune Collapse in Sepsis via Regulating Src Activation.
Autorzy :
Li W; Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Li Y; Department of Anesthesiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Qin K; Central Laboratory, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, China.
Du B; The Second Affiliated Hospital of Nantong University, Nantong, China.
Li T; National Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, Shanghai, China.
Yuan H; Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Han C; National Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, Shanghai, China.
Luo Y; Department of Anesthesiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
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Źródło :
Frontiers in immunology [Front Immunol] 2019 Nov 07; Vol. 10, pp. 2575. Date of Electronic Publication: 2019 Nov 07 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inflammation/*immunology
Lectins/*deficiency
Receptors, Antigen, B-Cell/*deficiency
Sepsis/*immunology
src-Family Kinases/*metabolism
Animals ; Cytokines/metabolism ; Enzyme Activation ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Interleukin-10/metabolism ; Lectins/physiology ; Macrophages/immunology ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Receptors, Antigen, B-Cell/physiology ; SH2 Domain-Containing Protein Tyrosine Phosphatases/metabolism ; STAT3 Transcription Factor/metabolism ; Sialic Acid Binding Immunoglobulin-like Lectins ; Signal Transduction ; Toll-Like Receptors/metabolism
Czasopismo naukowe
Tytuł :
Nitric Oxide Is Involved in Activation of Toll-Like Receptor 4 Signaling through Tyrosine Nitration of Src Homology Protein Tyrosine Phosphatase 2 in Murine Dextran Sulfate-Induced Colitis.
Autorzy :
Tun X; Physical Chemistry for Life Science Laboratory, Graduate School of Pharmaceutical Sciences, Kyushu University.
Yasukawa K; Laboratory of Advanced Pharmacology, Daiichi University of Pharmacy.
Yamada KI; Physical Chemistry for Life Science Laboratory, Graduate School of Pharmaceutical Sciences, Kyushu University.; Japan Science and Technology Agency, PRESTO.
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Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2018; Vol. 41 (12), pp. 1843-1852.
Typ publikacji :
Journal Article
MeSH Terms :
Colitis, Ulcerative/*metabolism
Intestinal Mucosa/*metabolism
Nitric Oxide/*metabolism
SH2 Domain-Containing Protein Tyrosine Phosphatases/*metabolism
Toll-Like Receptor 4/*metabolism
Tyrosine/*analogs & derivatives
Animals ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/immunology ; Dextran Sulfate ; Disease Models, Animal ; Inflammation ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/immunology ; Lipopolysaccharides/pharmacology ; Mice ; Nitric Oxide Donors/pharmacology ; Phosphorylation ; RAW 264.7 Cells ; Signal Transduction ; Tyrosine/metabolism
Czasopismo naukowe
Tytuł :
Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition
Autorzy :
Patrik Oleksak
Miroslav Psotka
Marketa Vancurova
Olena Sapega
Jana Bieblova
Milan Reinis
David Rysanek
Romana Mikyskova
Katarina Chalupova
David Malinak
Jana Svobodova
Rudolf Andrys
Helena Rehulkova
Vojtech Skopek
Pham Ngoc Lam
Jiri Bartek
Zdenek Hodny
Kamil Musilek
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Temat :
stat3 signalling pathway
cancer
sh2 domain
inhibitor
structure–activity relationship
Therapeutics. Pharmacology
RM1-950
Źródło :
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 410-424 (2021)
Opis pliku :
electronic resource
Relacje :
https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374
Dostęp URL :
https://doaj.org/article/cfac0c0e4320428ab38cfae14e7c28f8
Czasopismo naukowe
Tytuł :
Syk protein tyrosine kinase involves PECAM-1 signaling through tandem immunotyrosine inhibitory motifs in human THP-1 macrophages.
Autorzy :
Wang J; Department of Surgery and Pathology, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Pudong New District, Shanghai, PR China.
Wu Y
Hu H
Wang W
Lu Y
Mao H
Liu X
Liu Z
Chen BG
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Źródło :
Cellular immunology [Cell Immunol] 2011; Vol. 272 (1), pp. 39-44. Date of Electronic Publication: 2011 Sep 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Intracellular Signaling Peptides and Proteins/*immunology
Macrophages/*metabolism
Phosphotyrosine/*metabolism
Platelet Endothelial Cell Adhesion Molecule-1/*immunology
Protein-Tyrosine Kinases/*immunology
SH2 Domain-Containing Protein Tyrosine Phosphatases/*immunology
Signal Transduction/*immunology
src Homology Domains/*immunology
Amino Acid Motifs ; Binding Sites ; Cell Line ; Cell Proliferation/drug effects ; Flow Cytometry ; Gene Silencing/drug effects ; Humans ; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Macrophages/cytology ; Macrophages/immunology ; Molecular Sequence Data ; Peptides ; Phosphorylation/drug effects ; Phosphorylation/immunology ; Phosphotyrosine/genetics ; Phosphotyrosine/immunology ; Platelet Endothelial Cell Adhesion Molecule-1/genetics ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Protein Binding/genetics ; Protein Binding/immunology ; Protein Structure, Tertiary ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/metabolism ; RNA, Small Interfering/pharmacology ; SH2 Domain-Containing Protein Tyrosine Phosphatases/genetics ; SH2 Domain-Containing Protein Tyrosine Phosphatases/metabolism ; Signal Transduction/genetics ; Syk Kinase ; src Homology Domains/genetics
Czasopismo naukowe
Tytuł :
Valproic acid increases NO production via the SH-PTP1-CDK5-eNOS-Ser(116) signaling cascade in endothelial cells and mice.
Autorzy :
Cho DH; Department of Neurology, Konkuk University Medical Center, and Department of Pharmacology, Center for Geriatric Neuroscience Research, SMART Institute of Advanced Biomedical Science, and Gwangjin-gu, Seoul 143-701, Korea; Department of Pharmacology, School of Medicine, Eulji University, Jung-gu, Daejeon 301-746, Korea.
Park JH; Department of Molecular Medicine, Ewha Womans University Medical School, Yangcheon-gu, Seoul 158-710, Korea.
Joo Lee E; Department of Neurology, Konkuk University Medical Center, and Department of Pharmacology, Center for Geriatric Neuroscience Research, SMART Institute of Advanced Biomedical Science, and Gwangjin-gu, Seoul 143-701, Korea.
Jong Won K; Department of Medical Science, Institute of Functional Genomics, Konkuk University School of Medicine, Chungju 380-701, Korea.
Lee SH; Department of Microbiology, Chungbuk National University, Heungduk-gu, Cheongju 361-763, Korea.
Kim YH; Department of Microbiology, Chungbuk National University, Heungduk-gu, Cheongju 361-763, Korea.
Hwang S; Department of Molecular Medicine, Ewha Womans University Medical School, Yangcheon-gu, Seoul 158-710, Korea.
Ja Kwon K; Department of Neurology, Konkuk University Medical Center, and Department of Pharmacology, Center for Geriatric Neuroscience Research, SMART Institute of Advanced Biomedical Science, and Gwangjin-gu, Seoul 143-701, Korea.
Young Shin C; Department of Neurology, Konkuk University Medical Center, and Department of Pharmacology, Center for Geriatric Neuroscience Research, SMART Institute of Advanced Biomedical Science, and Gwangjin-gu, Seoul 143-701, Korea.
Song KH; Department of Internal Medicine, Konkuk University School of Medicine, Gwangjin-gu, Seoul 143-701, Korea.
Jo I; Department of Molecular Medicine, Ewha Womans University Medical School, Yangcheon-gu, Seoul 158-710, Korea. Electronic address: .
Han SH; Department of Neurology, Konkuk University Medical Center, and Department of Pharmacology, Center for Geriatric Neuroscience Research, SMART Institute of Advanced Biomedical Science, and Gwangjin-gu, Seoul 143-701, Korea. Electronic address: .
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Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2014 Nov; Vol. 76, pp. 96-106. Date of Electronic Publication: 2014 Aug 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anticonvulsants/*pharmacology
Aorta/*metabolism
Endothelium, Vascular/*metabolism
Nitric Oxide/*metabolism
Nitric Oxide Synthase Type III/*metabolism
Serine/*metabolism
Valproic Acid/*pharmacology
Animals ; Aorta/cytology ; Aorta/drug effects ; Blotting, Western ; Cattle ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Cyclin-Dependent Kinase 5/genetics ; Cyclin-Dependent Kinase 5/metabolism ; Endothelium, Vascular/cytology ; Endothelium, Vascular/drug effects ; Fluorescent Antibody Technique ; Immunoenzyme Techniques ; Immunoprecipitation ; Male ; Mice ; Mice, Inbred ICR ; Nitric Oxide Synthase Type III/genetics ; Phosphorylation/drug effects ; RNA, Messenger/genetics ; Reactive Oxygen Species/metabolism ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; SH2 Domain-Containing Protein Tyrosine Phosphatases ; Signal Transduction/drug effects ; Surface Plasmon Resonance
Czasopismo naukowe
Tytuł :
Thioredoxin-interacting protein is a biomechanical regulator of Src activity: key role in endothelial cell stress fiber formation.
Autorzy :
Spindel ON; From the Departments of Medicine (O.N.S., R.M.B., C.Y., B.C.B.) and Pharmacology and Physiology (O.N.S., C.Y., B.C.B.), University of Rochester School of Medicine and Dentistry, Aab Cardiovascular Research Institute, NY.
Burke RM
Yan C
Berk BC
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Źródło :
Circulation research [Circ Res] 2014 Mar 28; Vol. 114 (7), pp. 1125-32. Date of Electronic Publication: 2014 Feb 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Carrier Proteins/*metabolism
Human Umbilical Vein Endothelial Cells/*metabolism
Stress Fibers/*metabolism
Thioredoxins/*metabolism
src-Family Kinases/*metabolism
Animals ; Cadherins/metabolism ; Carrier Proteins/genetics ; Cattle ; Cell Membrane/metabolism ; Humans ; Mice ; Protein Binding ; Protein Transport ; SH2 Domain-Containing Protein Tyrosine Phosphatases/metabolism ; Thioredoxins/genetics
Czasopismo naukowe
Tytuł :
Specificity and regulation of phosphotyrosine signaling through SH2 domains
Autorzy :
Michelangelo Marasco
Teresa Carlomagno
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Temat :
SH2 domain
Phosphotyrosine
Binding specificity
pY signalling
Biology (General)
QH301-705.5
Źródło :
Journal of Structural Biology: X, Vol 4, Iss , Pp 100026- (2020)
Opis pliku :
electronic resource
Relacje :
http://www.sciencedirect.com/science/article/pii/S2590152420300088; https://doaj.org/toc/2590-1524
Dostęp URL :
https://doaj.org/article/2568e10506734a449f11d19e225e5a71
Czasopismo naukowe
Tytuł :
Src homology-2 domain-containing protein tyrosine phosphatase (SHP) 2 and p38 regulate the expression of chemokine CXCL8 in human astrocytes.
Autorzy :
Mamik MK; Department of Cell Biology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, USA.
Ghorpade A
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Źródło :
PloS one [PLoS One] 2012; Vol. 7 (9), pp. e45596. Date of Electronic Publication: 2012 Sep 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*metabolism
Interleukin-8/*metabolism
SH2 Domain-Containing Protein Tyrosine Phosphatases/*physiology
p38 Mitogen-Activated Protein Kinases/*physiology
Astrocytes/cytology ; Blotting, Western ; Cytokines/physiology ; HIV-1/physiology ; Humans ; Inflammation Mediators/physiology ; Phosphorylation
Czasopismo naukowe

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