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Tytuł :
Statin/ezetimibe combination therapy vs statin monotherapy for carotid atherosclerotic plaque inflammation.
Autorzy :
Oh M; Department of Nuclear Medicine.
Kim H; Department of Nuclear Medicine.
Shin EW; Department of Nuclear Medicine.
Sung C; Department of Nuclear Medicine.
Kim DH; Department of Nuclear Medicine.
Moon DH; Department of Nuclear Medicine.
Lee JS; Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Lee PH; Department of Medicine.
Lee SW; Department of Medicine.
Lee CW; Department of Medicine.
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Mar 12; Vol. 100 (10), pp. e25114.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Acute Coronary Syndrome/*drug therapy
Carotid Artery Diseases/*drug therapy
Ezetimibe, Simvastatin Drug Combination/*administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage
Plaque, Atherosclerotic/*drug therapy
Acute Coronary Syndrome/blood ; Acute Coronary Syndrome/immunology ; Aged ; C-Reactive Protein/analysis ; Carotid Arteries/diagnostic imaging ; Carotid Arteries/drug effects ; Carotid Arteries/immunology ; Carotid Artery Diseases/blood ; Carotid Artery Diseases/complications ; Carotid Artery Diseases/immunology ; Cholesterol, LDL/blood ; Clinical Trials as Topic ; Datasets as Topic ; Female ; Follow-Up Studies ; Humans ; Inflammation/complications ; Inflammation/drug therapy ; Inflammation/immunology ; Male ; Middle Aged ; Plaque, Atherosclerotic/blood ; Plaque, Atherosclerotic/complications ; Plaque, Atherosclerotic/immunology ; Rosuvastatin Calcium/administration & dosage ; Simvastatin/administration & dosage
Czasopismo naukowe
Tytuł :
Simvastatin-Incorporated Drug Delivery Systems for Bone Regeneration.
Autorzy :
Jin H; Department of Orthopedics, The Second Hospital of Jilin University, Changchun 130041, P.R. China.; Department of Pain, The Second Hospital of Jilin University, Changchun 130041, P.R. China.
Ji Y; Department of Pain, The Second Hospital of Jilin University, Changchun 130041, P.R. China.
Cui Y; Department of Orthopedics, The Second Hospital of Jilin University, Changchun 130041, P.R. China.
Xu L; Department of Orthopedics, Weihai Guanghua Hospital, Weihai 264200, P.R. China.
Liu H; Department of Orthopedics, The Second Hospital of Jilin University, Changchun 130041, P.R. China.
Wang J; Department of Orthopedics, The Second Hospital of Jilin University, Changchun 130041, P.R. China.
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Źródło :
ACS biomaterials science & engineering [ACS Biomater Sci Eng] 2021 Jun 14; Vol. 7 (6), pp. 2177-2191. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Osteogenesis*
Simvastatin*
Bone Regeneration ; Cell Differentiation ; Drug Delivery Systems
Czasopismo naukowe
Tytuł :
Simvastatin mitigates depressive-like behavior in ovariectomized rats: Possible role of NLRP3 inflammasome and estrogen receptors' modulation.
Autorzy :
Menze ET; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Ezzat H; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Shawky S; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Sami M; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Selim EH; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Ahmed S; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Maged N; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Nadeem N; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Eldash S; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Michel HE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: .
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2021 Jun; Vol. 95, pp. 107582. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Journal Article
MeSH Terms :
Antidepressive Agents/*therapeutic use
Depression/*drug therapy
Estrogen Receptor Modulators/*therapeutic use
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
Simvastatin/*therapeutic use
Animals ; Antidepressive Agents/pharmacology ; Behavior, Animal/drug effects ; Depression/metabolism ; Estradiol/blood ; Estradiol/metabolism ; Estrogen Receptor Modulators/pharmacology ; Estrogen Receptor alpha/genetics ; Estrogen Receptor beta/genetics ; Female ; Hippocampus/drug effects ; Hippocampus/metabolism ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Inflammasomes/genetics ; Microglia/drug effects ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Ovariectomy ; Rats, Sprague-Dawley ; Simvastatin/pharmacology ; Uterus/drug effects ; Uterus/metabolism
Czasopismo naukowe
Tytuł :
Severe rhabdomyolysis induced by possible drug-drug interaction between Ribociclib and Simvastatin.
Autorzy :
Streicher C; Unité de préparation et de contrôle pharmaceutique, Centre Hospitalier de Brive La Gaillarde, Brive La Gaillarde Cedex, France.; Service d'oncologie, Centre Hospitalier de Brive La Gaillarde, Brive La Gaillarde Cedex, France.
Daulange A; Unité de préparation et de contrôle pharmaceutique, Centre Hospitalier de Brive La Gaillarde, Brive La Gaillarde Cedex, France.; Service d'oncologie, Centre Hospitalier de Brive La Gaillarde, Brive La Gaillarde Cedex, France.
Madranges N; Service d'oncologie, Centre Hospitalier de Brive La Gaillarde, Brive La Gaillarde Cedex, France.
Vayre L; Service d'oncologie, Centre Hospitalier de Brive La Gaillarde, Brive La Gaillarde Cedex, France.
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Źródło :
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners [J Oncol Pharm Pract] 2021 Apr; Vol. 27 (3), pp. 722-726. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Severity of Illness Index*
Aminopyridines/*adverse effects
Purines/*adverse effects
Rhabdomyolysis/*chemically induced
Rhabdomyolysis/*diagnosis
Simvastatin/*adverse effects
Aged ; Aminopyridines/blood ; Creatine Kinase/blood ; Drug Interactions/physiology ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/blood ; Purines/blood ; Rhabdomyolysis/blood ; Simvastatin/blood
Czasopismo naukowe
Tytuł :
Osteogenic effects in a rat osteoporosis model and femur defect model by simvastatin microcrystals.
Autorzy :
Zhu J; Department of Orthopedics, Peking University Third Hospital, Beijing, China.
Zhang C; Department of Orthopedics, Peking University Third Hospital, Beijing, China.
Jia J; Department of Orthopedics, Peking University Third Hospital, Beijing, China.
Wang H; Department of Orthopedics, Peking University Third Hospital, Beijing, China.; Beijing Key Laboratory of Spinal Diseases, Beijing, China.
Leng H; Department of Orthopedics, Peking University Third Hospital, Beijing, China.; Beijing Key Laboratory of Spinal Diseases, Beijing, China.
Xu Y; Department of Neurology, Peking University Third Hospital, Beijing, China.
Wu C; Beijing Delivery Pharmaceutical Technology Co., Ltd, Beijing, China.
Zhang Q; Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Song C; Department of Orthopedics, Peking University Third Hospital, Beijing, China.; Beijing Key Laboratory of Spinal Diseases, Beijing, China.
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Źródło :
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2021 Mar; Vol. 1487 (1), pp. 31-42. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Osteoporosis/*drug therapy
Simvastatin/*administration & dosage
Simvastatin/*pharmacology
Animals ; Bone Density/drug effects ; Crystallization ; Disease Models, Animal ; Drug Compounding/methods ; Female ; Femur/drug effects ; Osteogenesis/drug effects ; Osteoporosis/pathology ; Ovariectomy ; Particle Size ; Poloxamer/administration & dosage ; Poloxamer/chemistry ; Poloxamer/pharmacology ; Rats ; Rats, Sprague-Dawley ; Simvastatin/chemistry ; X-Ray Microtomography
Czasopismo naukowe
Tytuł :
In-vivo evaluation of Alginate-Pectin hydrogel film loaded with Simvastatin for diabetic wound healing in Streptozotocin-induced diabetic rats.
Autorzy :
Rezvanian M; Centre for Drug Delivery Research, Faculty of Pharmacy, 50300, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. Electronic address: .
Ng SF; Centre for Drug Delivery Research, Faculty of Pharmacy, 50300, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Alavi T; Centre for Drug Delivery Research, Faculty of Pharmacy, 50300, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Ahmad W; School of Pharmaceutical Sciences, 11800, Universiti Sains Malaysia, Pulau Pinang, Malaysia.
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Feb 28; Vol. 171, pp. 308-319. Date of Electronic Publication: 2021 Jan 07.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Dressings*
Hydrogels*/administration & dosage
Hydrogels*/pharmacology
Hydrogels*/therapeutic use
Alginates/*administration & dosage
Diabetes Mellitus, Experimental/*complications
Pectins/*administration & dosage
Simvastatin/*administration & dosage
Wound Healing/*drug effects
Alginates/chemistry ; Animals ; Collagen/biosynthesis ; Drug Evaluation, Preclinical ; Drug Repositioning ; Hydroxyproline/analysis ; Male ; Materials Testing ; Neovascularization, Physiologic/drug effects ; Pectins/chemistry ; Random Allocation ; Rats ; Rats, Wistar ; Re-Epithelialization/drug effects ; Simvastatin/pharmacology ; Simvastatin/therapeutic use ; Skin/injuries ; Vascular Endothelial Growth Factor A/biosynthesis
Czasopismo naukowe
Tytuł :
Simvastatin ointment in the treatment of seven childhood diffuse plane xanthomas.
Autorzy :
Yu X; Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.; Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yang L; National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), School of Public Health, Fudan University, Shanghai, China.
Gu Y; Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.; Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhang W; Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.; Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhang Z; Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.; Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Guo Y; Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.; Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yao Z; Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.; Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China.
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Źródło :
The Journal of dermatology [J Dermatol] 2021 Feb; Vol. 48 (2), pp. 223-227. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article
MeSH Terms :
Simvastatin*/therapeutic use
Xanthomatosis*/drug therapy
Child ; Emollients ; Humans ; Ointments ; Skin ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Effects of Liposomal Simvastatin Nanoparticles on Vascular Endothelial Function and Arterial Smooth Muscle Cell Apoptosis in Rats with Arteriosclerotic Occlusive Disease of Lower Limb via P38 Mitogen-Activated Protein Kinase Nuclear Factor Kappa-B Pathway.
Autorzy :
Wu J; Department of Vascular Surgery, Quzhou People's Hospital, Quzhou City, 324000, Zhejiang Province, China.
Liao S; Department of Vascular Surgery, Quzhou People's Hospital, Quzhou City, 324000, Zhejiang Province, China.
Hu Q; Department of Vascular Surgery, Quzhou People's Hospital, Quzhou City, 324000, Zhejiang Province, China.
Wu S; Department of Vascular Surgery, Quzhou People's Hospital, Quzhou City, 324000, Zhejiang Province, China.
Qiu S; Department of Cardio-Thoracic Surgery, Quzhou People's Hospital, Quzhou City, 324000, Zhejiang Province, China.
Cheng G; Department of Vascular Surgery, Quzhou People's Hospital, Quzhou City, 324000, Zhejiang Province, China.
Li X; Department of Vascular Surgery, Quzhou People's Hospital, Quzhou City, 324000, Zhejiang Province, China.
Lu W; Department of Vascular Surgery, Quzhou People's Hospital, Quzhou City, 324000, Zhejiang Province, China.
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Źródło :
Journal of nanoscience and nanotechnology [J Nanosci Nanotechnol] 2021 Feb 01; Vol. 21 (2), pp. 1169-1175.
Typ publikacji :
Journal Article
MeSH Terms :
Nanoparticles*
Simvastatin*/pharmacology
Animals ; Apoptosis ; Lower Extremity ; Myocytes, Smooth Muscle ; NF-kappa B ; Rats ; Rats, Sprague-Dawley ; p38 Mitogen-Activated Protein Kinases
Czasopismo naukowe
Tytuł :
Physiologically Based Precision Dosing Approach for Drug-Drug-Gene Interactions: A Simvastatin Network Analysis.
Autorzy :
Wojtyniak JG; Clinical Pharmacy, Saarland University, Saarbrücken, Germany.; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
Selzer D; Clinical Pharmacy, Saarland University, Saarbrücken, Germany.
Schwab M; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; Departments of Clinical Pharmacology and Pharmacy and Biochemistry, University of Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180) 'Image-guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.
Lehr T; Clinical Pharmacy, Saarland University, Saarbrücken, Germany.
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Źródło :
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2021 Jan; Vol. 109 (1), pp. 201-211. Date of Electronic Publication: 2020 Dec 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Interactions/*genetics
Simvastatin/*administration & dosage
ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Adult ; Computer Simulation ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 CYP3A/metabolism ; Humans ; Liver-Specific Organic Anion Transporter 1/genetics ; Liver-Specific Organic Anion Transporter 1/metabolism ; Male ; Models, Biological ; Polymorphism, Genetic/genetics ; Precision Medicine/methods ; Simvastatin/pharmacokinetics
Czasopismo naukowe
Tytuł :
Tanshinone I and simvastatin inhibit melanoma tumour cell growth by regulating poly (ADP ribose) polymerase 1 expression.
Autorzy :
Zhang Y; Department of Pharmacy, Guangzhou Institute of Dermatology, Guangzhou, Guangdong 510095, P.R. China.
Huang J; Department of Pharmacy, Guangzhou Institute of Dermatology, Guangzhou, Guangdong 510095, P.R. China.
Huang Y; Department of Urology, Minimally Invasive Surgery Centre, Guangzhou Urology Research Institute, Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510230, P.R. China.
Zhang S; Department of Urology, Minimally Invasive Surgery Centre, Guangzhou Urology Research Institute, Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510230, P.R. China.
Wu W; Department of Urology, Minimally Invasive Surgery Centre, Guangzhou Urology Research Institute, Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510230, P.R. China.
Long H; Department of Pharmacy, Guangzhou Institute of Dermatology, Guangzhou, Guangdong 510095, P.R. China.
Duan X; Department of Urology, Minimally Invasive Surgery Centre, Guangzhou Urology Research Institute, Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510230, P.R. China.
Lai Y; Department of Urology, The Eighth Affiliated Hospital, Sun Yat‑sen University, Shenzhen, Guangdong 518033, P.R. China.
Wu W; Department of Urology, Minimally Invasive Surgery Centre, Guangzhou Urology Research Institute, Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510230, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Jan; Vol. 23 (1). Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article
MeSH Terms :
Abietanes/*administration & dosage
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Melanoma/*drug therapy
Poly (ADP-Ribose) Polymerase-1/*metabolism
Simvastatin/*administration & dosage
Abietanes/pharmacology ; Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Synergism ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Melanoma/metabolism ; Mice ; Simvastatin/pharmacology ; Survival Analysis ; Up-Regulation/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Periadventitial Delivery of Simvastatin-Loaded Microparticles Attenuate Venous Neointimal Hyperplasia Associated With Arteriovenous Fistula.
Autorzy :
Zhao C; Vascular and Interventional Radiology Translational Laboratory Department of Radiology Mayo Clinic Rochester MN.; Department of Vascular Surgery The Second Xiangya HospitalCentral South University Changsha Hunan China.
Zuckerman ST; Affinity Therapeutics, LLC Cleveland OH.
Cai C; Vascular and Interventional Radiology Translational Laboratory Department of Radiology Mayo Clinic Rochester MN.; Department of Vascular Surgery Union Hospital Tongji Medical CollegeHuazhong University of Science and Technology Wuhan China.
Kilari S; Vascular and Interventional Radiology Translational Laboratory Department of Radiology Mayo Clinic Rochester MN.
Singh A; Vascular and Interventional Radiology Translational Laboratory Department of Radiology Mayo Clinic Rochester MN.
Simeon M; Vascular and Interventional Radiology Translational Laboratory Department of Radiology Mayo Clinic Rochester MN.
von Recum HA; Department of Biomedical Engineering Case Western Reserve University Cleveland OH.
Korley JN; Affinity Therapeutics, LLC Cleveland OH.
Misra S; Vascular and Interventional Radiology Translational Laboratory Department of Radiology Mayo Clinic Rochester MN.; Department of Biochemistry and Molecular Biology Mayo Clinic Rochester MN.
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Źródło :
Journal of the American Heart Association [J Am Heart Assoc] 2020 Dec 15; Vol. 9 (24), pp. e018418. Date of Electronic Publication: 2020 Dec 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Arteriovenous Fistula/*pathology
Hyperplasia/*prevention & control
Neointima/*pathology
Simvastatin/*therapeutic use
Animals ; Anticholesteremic Agents/administration & dosage ; Anticholesteremic Agents/adverse effects ; Anticholesteremic Agents/therapeutic use ; Chemokine CCL2/drug effects ; Chemokine CCL2/metabolism ; Cyclodextrins/metabolism ; Drug Delivery Systems/methods ; Fibrosis/metabolism ; Graft Occlusion, Vascular/prevention & control ; Hyperplasia/etiology ; Inflammation/metabolism ; Kidney Failure, Chronic/therapy ; Male ; Matrix Metalloproteinase 9/drug effects ; Matrix Metalloproteinase 9/metabolism ; Mice ; Mice, Inbred C57BL ; Models, Animal ; Simvastatin/administration & dosage ; Simvastatin/adverse effects ; Transforming Growth Factor beta1/drug effects ; Transforming Growth Factor beta1/metabolism ; Vascular Endothelial Growth Factor A/drug effects ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Remodeling/drug effects ; Veins/metabolism
Czasopismo naukowe
Tytuł :
Simvastatin can enhance the osseointegration of titanium rods in ovariectomized rats maintenance treatment with valproic acid.
Autorzy :
Tao ZS; Department of Trauma Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, No. 2, Zhe Shan Xi Road, Wuhu 241001, Anhui, People's Republic of China.
Zhou WS; Department of Geriatrics, the Second Affiliated Hospital of Wannan Medical College, No.123, Kangfu Road, Wuhu 241000, Anhui, People's Republic of China.
Xu HG; Department of Spinal Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, No. 2, Zhe Shan Xi Road, Wuhu 241001, Anhui, People's Republic of China.
Yang M; Department of Trauma Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, No. 2, Zhe Shan Xi Road, Wuhu 241001, Anhui, People's Republic of China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Dec; Vol. 132, pp. 110745. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article
MeSH Terms :
Osteoporosis/*therapy
Simvastatin/*pharmacology
Titanium/*chemistry
Valproic Acid/*toxicity
3T3 Cells ; Animals ; Anticonvulsants/administration & dosage ; Anticonvulsants/toxicity ; Female ; Gene Expression Regulation ; Mice ; Osseointegration/drug effects ; Osteogenesis/drug effects ; Osteoporosis/genetics ; Osteoporosis/pathology ; Ovariectomy ; Prostheses and Implants ; Prosthesis Design ; Rats ; Rats, Sprague-Dawley ; Simvastatin/administration & dosage ; Valproic Acid/administration & dosage ; X-Ray Microtomography
Czasopismo naukowe
Tytuł :
Transgenerational inheritance of chemical-induced signature: A case study with simvastatin.
Autorzy :
Neuparth T; CIMAR/CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal. Electronic address: .
Machado AM; CIMAR/CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal; FCUP - Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal.
Montes R; Department of Analytical Chemistry, Nutrition and Food Sciences, IAQBUS - Institute of Research on Chemical and Biological Analysis, Universidade de Santiago de Compostela, R. Constantino Candeira S/N, 15782 Santiago de Compostela, Spain.
Rodil R; Department of Analytical Chemistry, Nutrition and Food Sciences, IAQBUS - Institute of Research on Chemical and Biological Analysis, Universidade de Santiago de Compostela, R. Constantino Candeira S/N, 15782 Santiago de Compostela, Spain.
Barros S; CIMAR/CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.
Alves N; CIMAR/CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.
Ruivo R; CIMAR/CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.
Castro LFC; CIMAR/CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal; FCUP - Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal.
Quintana JB; Department of Analytical Chemistry, Nutrition and Food Sciences, IAQBUS - Institute of Research on Chemical and Biological Analysis, Universidade de Santiago de Compostela, R. Constantino Candeira S/N, 15782 Santiago de Compostela, Spain.
Santos MM; CIMAR/CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal; FCUP - Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal. Electronic address: .
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Źródło :
Environment international [Environ Int] 2020 Nov; Vol. 144, pp. 106020. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amphipoda*
Simvastatin*/toxicity
Animals ; Epigenesis, Genetic ; Humans ; Reproduction
Czasopismo naukowe
Tytuł :
Simvastatin improves mitochondrial respiration in peripheral blood cells.
Autorzy :
Durhuus JA; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.; The HNPCC Register, Clinical Research Center, Copenhagen University Hospital, Hvidovre, Denmark.
Hansson S; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Morville T; Department of Biomedical Sciences, XLAB, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Kuhlman AB; Department of Biomedical Sciences, XLAB, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Dohlmann TL; Department of Biomedical Sciences, XLAB, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Larsen S; Department of Biomedical Sciences, XLAB, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.; Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland.
Helge JW; Department of Biomedical Sciences, XLAB, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Angleys M; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Muniesa-Vargas A; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Bundgaard JR; Department of Clinical Biochemistry, University of Copenhagen, Copenhagen, Denmark.
Hickson ID; Department of Cellular and Molecular Medicine, Center for Healthy Aging, Center for Chromosome Stability, University of Copenhagen, Copenhagen, Denmark.
Dela F; Department of Biomedical Sciences, XLAB, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.; Department of Geriatrics, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark.
Desler C; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark. .
Rasmussen LJ; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark. .
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Źródło :
Scientific reports [Sci Rep] 2020 Oct 12; Vol. 10 (1), pp. 17012. Date of Electronic Publication: 2020 Oct 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood Platelets/*drug effects
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology
Hypercholesterolemia/*drug therapy
Leukocytes, Mononuclear/*drug effects
Mitochondria/*drug effects
Simvastatin/*pharmacology
Blood Platelets/metabolism ; Cell Line ; Electron Transport Complex I/metabolism ; Electron Transport Complex IV/metabolism ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hypercholesterolemia/metabolism ; Leukocytes, Mononuclear/metabolism ; Male ; Middle Aged ; Mitochondria/metabolism ; Oxygen Consumption/drug effects ; Simvastatin/therapeutic use ; Superoxides/metabolism
Czasopismo naukowe
Tytuł :
Effects of simvastatin on iNOS and caspase‑3 levels and oxidative stress following smoke inhalation injury.
Autorzy :
Yang RQ; Department of Burn and Repair Reconstruction Surgery, The School of Basic Medical Science of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Guo PF; Department of Burn and Repair Reconstruction Surgery, The School of Basic Medical Science of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Ma Z; Department of Burn and Repair Reconstruction Surgery, The School of Basic Medical Science of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Chang C; Department of Burn and Repair Reconstruction Surgery, The School of Basic Medical Science of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Meng QN; Department of Burn and Repair Reconstruction Surgery, The School of Basic Medical Science of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Gao Y; Department of Burn and Repair Reconstruction Surgery, The School of Basic Medical Science of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Khan I; Department of Burn and Repair Reconstruction Surgery, The School of Basic Medical Science of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Wang XB; Department of Burn and Repair Reconstruction Surgery, The School of Basic Medical Science of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Cui ZJ; Department of Burn and Repair Reconstruction Surgery, The School of Basic Medical Science of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2020 Oct; Vol. 22 (4), pp. 3405-3417. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article
MeSH Terms :
Caspase 3/*metabolism
Nitric Oxide Synthase Type II/*metabolism
Oxidative Stress/*drug effects
Simvastatin/*administration & dosage
Smoke Inhalation Injury/*drug therapy
Animals ; Caspase 3/blood ; Caspase 3/genetics ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Gene Expression Regulation/drug effects ; Lung/metabolism ; Male ; Malondialdehyde/blood ; Malondialdehyde/metabolism ; Nitric Oxide Synthase Type II/blood ; Nitric Oxide Synthase Type II/genetics ; Rats ; Rats, Sprague-Dawley ; Simvastatin/pharmacology ; Smoke Inhalation Injury/chemically induced ; Smoke Inhalation Injury/genetics ; Smoke Inhalation Injury/metabolism ; Superoxide Dismutase/blood ; Superoxide Dismutase/metabolism ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Chronopharmacology of simvastatin on hyperlipidaemia in high-fat diet-fed obese mice.
Autorzy :
Li H; School of Life Sciences and Technology, China Pharmaceutical University, Nanjing, China.
Rabearivony A; School of Life Sciences and Technology, China Pharmaceutical University, Nanjing, China.
Zhang W; School of Life Sciences and Technology, China Pharmaceutical University, Nanjing, China.
Chen S; School of Life Sciences and Technology, China Pharmaceutical University, Nanjing, China.
An X; Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Liu C; School of Life Sciences and Technology, China Pharmaceutical University, Nanjing, China.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2020 Sep; Vol. 24 (18), pp. 11024-11029. Date of Electronic Publication: 2020 Aug 07.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Circadian Rhythm Signaling Peptides and Proteins/*physiology
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacokinetics
Hyperlipidemias/*drug therapy
Simvastatin/*pharmacokinetics
Animals ; Chronopharmacokinetics ; Circadian Clocks/drug effects ; Circadian Rhythm Signaling Peptides and Proteins/biosynthesis ; Circadian Rhythm Signaling Peptides and Proteins/genetics ; Diet, High-Fat/adverse effects ; Drug Chronotherapy ; Gene Expression Regulation/drug effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hypercholesterolemia/drug therapy ; Hypercholesterolemia/metabolism ; Hypercholesterolemia/pathology ; Hyperlipidemias/metabolism ; Hyperlipidemias/pathology ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Male ; Mice ; Mice, Obese ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Random Allocation ; Simvastatin/administration & dosage ; Simvastatin/therapeutic use
Czasopismo naukowe
Tytuł :
Enhancing the Hypolipidemic Effect of Simvastatin in Poloxamer-Induced Hyperlipidemic Rats via Liquisolid Approach: Pharmacokinetic and Pharmacodynamic Evaluation.
Autorzy :
El-Say KM; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. .; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt. .
Ahmed TA; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Ahmed OAA; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Minia University, Minya, Egypt.
Elimam H; Department of Biochemistry, Faculty of Pharmacy, University of Sadat City, Sadat City, Monufia, Egypt.
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Źródło :
AAPS PharmSciTech [AAPS PharmSciTech] 2020 Aug 04; Vol. 21 (6), pp. 223. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article
MeSH Terms :
Hypolipidemic Agents/*pharmacology
Simvastatin/*pharmacology
Animals ; Biological Availability ; Male ; Poloxamer/toxicity ; Rats ; Rats, Wistar ; Simvastatin/chemistry ; Simvastatin/pharmacokinetics ; Solubility ; Tablets
Czasopismo naukowe
Tytuł :
Enhancing the oral bioavailability of simvastatin with silica-lipid hybrid particles: The effect of supersaturation and silica geometry.
Autorzy :
Meola TR; University of South Australia, Clinical and Health Sciences, Adelaide, South Australia 5000, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, University of South Australia, City West Campus, Adelaide, South Australia 5000, Australia.
Schultz HB; University of South Australia, Clinical and Health Sciences, Adelaide, South Australia 5000, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, University of South Australia, City West Campus, Adelaide, South Australia 5000, Australia.
Peressin KF; University of South Australia, Clinical and Health Sciences, Adelaide, South Australia 5000, Australia.
Prestidge CA; University of South Australia, Clinical and Health Sciences, Adelaide, South Australia 5000, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, University of South Australia, City West Campus, Adelaide, South Australia 5000, Australia. Electronic address: .
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2020 Jul 01; Vol. 150, pp. 105357. Date of Electronic Publication: 2020 May 20.
Typ publikacji :
Journal Article
MeSH Terms :
Caprylates/*administration & dosage
Diglycerides/*administration & dosage
Drug Carriers/*administration & dosage
Glycerides/*administration & dosage
Hypolipidemic Agents/*administration & dosage
Monoglycerides/*administration & dosage
Silicon Dioxide/*administration & dosage
Simvastatin/*administration & dosage
Administration, Oral ; Animals ; Biological Availability ; Caprylates/chemistry ; Caprylates/pharmacokinetics ; Diglycerides/chemistry ; Diglycerides/pharmacokinetics ; Drug Carriers/chemistry ; Drug Carriers/pharmacokinetics ; Drug Liberation ; Glycerides/chemistry ; Glycerides/pharmacokinetics ; Hypolipidemic Agents/blood ; Hypolipidemic Agents/chemistry ; Hypolipidemic Agents/pharmacokinetics ; Male ; Monoglycerides/chemistry ; Monoglycerides/pharmacokinetics ; Rats, Sprague-Dawley ; Silicon Dioxide/chemistry ; Silicon Dioxide/pharmacokinetics ; Simvastatin/blood ; Simvastatin/chemistry ; Simvastatin/pharmacokinetics
Czasopismo naukowe
Tytuł :
Niosomal delivery of simvastatin to MDA-MB-231 cancer cells.
Autorzy :
Akbarzadeh I; Department of Nanobiotechnology, New Technologies Research Group, Pasteur Institute of Iran, Tehran, Iran.; Department of Chemical and Petrochemical Engineering, Sharif University of Technology, Tehran, Iran.
Saremi Poor A; Department of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
Yaghmaei S; Department of Chemical and Petrochemical Engineering, Sharif University of Technology, Tehran, Iran.
Norouzian D; Department of Nanobiotechnology, New Technologies Research Group, Pasteur Institute of Iran, Tehran, Iran.
Noorbazargan H; Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Saffar S; Core Facility Center, Pasteur Institute of Iran, Tehran, Iran.
Ahangari Cohan R; Department of Nanobiotechnology, New Technologies Research Group, Pasteur Institute of Iran, Tehran, Iran.
Bakhshandeh H; Department of Nanobiotechnology, New Technologies Research Group, Pasteur Institute of Iran, Tehran, Iran.
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Źródło :
Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2020 Sep; Vol. 46 (9), pp. 1535-1549. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article
MeSH Terms :
Neoplasms*
Simvastatin*/pharmacology
Liposomes/*chemistry
Particle Size
Czasopismo naukowe
Tytuł :
Effects of multidose simvastatin co-administration on pharmacokinetic profile of apatinib in rats by UPLC-MS/MS.
Autorzy :
Gao J; Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Ren H; Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Feng Z; Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Chen S; Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Liang Y; Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Liu W; Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Zhou Q; Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Wang M; Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Sep; Vol. 50 (9), pp. 1115-1120. Date of Electronic Publication: 2020 Mar 19.
Typ publikacji :
Journal Article
MeSH Terms :
Pyridines/*pharmacokinetics
Simvastatin/*pharmacokinetics
Animals ; Area Under Curve ; Chromatography, Liquid ; Cytochrome P-450 CYP3A ; Protein Kinase Inhibitors ; Pyridines/administration & dosage ; Rats ; Rats, Sprague-Dawley ; Simvastatin/administration & dosage
Czasopismo naukowe

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