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Tytuł:
Simvastatin Preferentially Targets FLT3/ITD Acute Myeloid Leukemia by Inhibiting MEK/ERK and p38-MAPK Signaling Pathways.
Autorzy:
Li G; Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, 361003, People's Republic of China.; Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy, Xiamen, 361003, People's Republic of China.; Xiamen Key Laboratory of Biomarker Translational Medicine, Medical Laboratory of Xiamen Humanity Hospital Fujian Medical University, Xiamen, 361003, People's Republic of China.
Yao J; Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, 361003, People's Republic of China.; Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy, Xiamen, 361003, People's Republic of China.
Lu Z; Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, 361003, People's Republic of China.; Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy, Xiamen, 361003, People's Republic of China.
Yu L; Department of Hematology and Rheumatology, Longyan First Hospital, Affiliated to Fujian Medical University, Longyan, 364000, People's Republic of China.
Chen Q; Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, 361003, People's Republic of China.; Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy, Xiamen, 361003, People's Republic of China.
Ding L; Department of Pathology, The First Affiliated Hospital of Xiamen University, Xiamen, 361003, People's Republic of China.
Fang Z; Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, 361003, People's Republic of China. jeho_.; Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy, Xiamen, 361003, People's Republic of China. jeho_.
Li Y; Department of Oncology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, 510630, People's Republic of China. .
Xu B; Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, 361003, People's Republic of China. .; Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy, Xiamen, 361003, People's Republic of China. .
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Źródło:
Drugs in R&D [Drugs R D] 2023 Dec; Vol. 23 (4), pp. 439-451. Date of Electronic Publication: 2023 Oct 17.
Typ publikacji:
Journal Article
MeSH Terms:
Simvastatin*/pharmacology
Simvastatin*/therapeutic use
Leukemia, Myeloid, Acute*/drug therapy
Leukemia, Myeloid, Acute*/genetics
Leukemia, Myeloid, Acute*/pathology
Humans ; Animals ; Mice ; Leukocytes, Mononuclear/metabolism ; Mevalonic Acid/pharmacology ; Mevalonic Acid/therapeutic use ; Protein Kinase Inhibitors/therapeutic use ; Apoptosis ; Signal Transduction ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Mitogen-Activated Protein Kinase Kinases/pharmacology ; Mitogen-Activated Protein Kinase Kinases/therapeutic use ; fms-Like Tyrosine Kinase 3/genetics ; fms-Like Tyrosine Kinase 3/metabolism ; fms-Like Tyrosine Kinase 3/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Formulation and evaluation of simvastatin cubosomal nanoparticles for assessing its wound healing effect.
Autorzy:
Ahmed LM; Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt.
Hassanein KMA; Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, 71526, Egypt.
Mohamed FA; Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt.
Elfaham TH; Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt. .
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 20; Vol. 13 (1), pp. 17941. Date of Electronic Publication: 2023 Oct 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Simvastatin*/pharmacology
Nanoparticles*
Humans ; Rats ; Animals ; Poloxamer/pharmacology ; Wound Healing ; Hydrogels/pharmacology ; Particle Size
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inhibitory Effects of Simvastatin on IL-33-Induced MCP-1 via the Suppression of the JNK Pathway in Human Vascular Endothelial Cells.
Autorzy:
Umebashi K; Institute for Clinical Research, National Hospital Organization Kagoshima Medical Center, Kagoshima 892-0853, Japan.
Yamamoto M; Institute for Clinical Research, National Hospital Organization Kagoshima Medical Center, Kagoshima 892-0853, Japan.
Tokito A; Institute for Clinical Research, National Hospital Organization Kagoshima Medical Center, Kagoshima 892-0853, Japan.
Sudou K; Institute for Clinical Research, National Hospital Organization Kagoshima Medical Center, Kagoshima 892-0853, Japan.
Takenoshita Y; Institute for Clinical Research, National Hospital Organization Kagoshima Medical Center, Kagoshima 892-0853, Japan.
Jougasaki M; Institute for Clinical Research, National Hospital Organization Kagoshima Medical Center, Kagoshima 892-0853, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 21; Vol. 24 (16). Date of Electronic Publication: 2023 Aug 21.
Typ publikacji:
Journal Article
MeSH Terms:
Simvastatin*/pharmacology
MAP Kinase Signaling System*
Humans ; Interleukin-33 ; Human Umbilical Vein Endothelial Cells ; Inflammation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Statins-Their Role in Bone Tissue Metabolism and Local Applications with Different Carriers.
Autorzy:
Granat MM; Department of Clinical and Experimental Pharmacology, Faculty of Medicine, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland.
Eifler-Zydel J; Department of Pharmaceutical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland.
Kolmas J; Department of Pharmaceutical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 17; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 17.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Hydroxymethylglutaryl-CoA Reductase Inhibitors*/pharmacology
Hydroxymethylglutaryl-CoA Reductase Inhibitors*/therapeutic use
Osteoporosis*/drug therapy
Humans ; Simvastatin/pharmacology ; Simvastatin/therapeutic use ; Cholesterol, LDL ; Bone and Bones
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Evaluating synergistic effects of metformin and simvastatin on ovarian cancer cells.
Autorzy:
Mikhael S; Laboratory of Cancer and Metabolism, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.
Kurdi A; Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Khoueiry-Zgheib N; Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Tahtouh R; Laboratory of Cancer and Metabolism, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.
Nasr R; Department of Anatomy, Cell Biology, and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Hilal G; Laboratory of Cancer and Metabolism, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.
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Źródło:
PloS one [PLoS One] 2024 Mar 15; Vol. 19 (3), pp. e0298127. Date of Electronic Publication: 2024 Mar 15 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/genetics
Ovarian Neoplasms*/pathology
Metformin*/pharmacology
Metformin*/therapeutic use
Humans ; Female ; Apoptosis ; Simvastatin/pharmacology ; Simvastatin/therapeutic use ; Cell Line, Tumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A systematic review of case series and clinical trials investigating systemic oral or injectable therapies for the treatment of vitiligo.
Autorzy:
Jafarzadeh A; Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Pour Mohammad A; Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Khosravi M; Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Amiri S; Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Rasouli A; School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Keramati H; Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Goodarzi A; Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
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Źródło:
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) [Skin Res Technol] 2024 Mar; Vol. 30 (3), pp. e13642.
Typ publikacji:
Systematic Review; Journal Article; Review
MeSH Terms:
Vitiligo*/drug therapy
Vitiligo*/pathology
Hypopigmentation*
Purines*
Pyrazoles*
Sulfonamides*
Azetidines*
Thalidomide/*analogs & derivatives
Humans ; Methotrexate/therapeutic use ; Azathioprine/therapeutic use ; Mycophenolic Acid/therapeutic use ; Minocycline/therapeutic use ; Alefacept/therapeutic use ; Cyclosporine/therapeutic use ; Adrenal Cortex Hormones ; Simvastatin/therapeutic use ; Zinc/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mutant p53 murine oviductal epithelial cells induce progression of high-grade serous carcinoma and are most sensitive to simvastatin therapy in vitro and in vivo.
Autorzy:
Pereira M; Department of Biomedical Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Glogova A; Department of Biomedical Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Haagsma J; The Mary & John Knight Translational Ovarian Cancer Research Unit, London Regional Cancer Program, London, ON, Canada.; Department of Anatomy & Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Stewart J; Department of Biomedical Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Shepherd TG; The Mary & John Knight Translational Ovarian Cancer Research Unit, London Regional Cancer Program, London, ON, Canada.; Department of Anatomy & Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Department of Obstetrics & Gynaecology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Petrik J; Department of Biomedical Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada. .
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Źródło:
Journal of ovarian research [J Ovarian Res] 2023 Nov 20; Vol. 16 (1), pp. 218. Date of Electronic Publication: 2023 Nov 20.
Typ publikacji:
Journal Article
MeSH Terms:
Hydroxymethylglutaryl-CoA Reductase Inhibitors*/pharmacology
Hydroxymethylglutaryl-CoA Reductase Inhibitors*/therapeutic use
Hydroxymethylglutaryl-CoA Reductase Inhibitors*/metabolism
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/genetics
Ovarian Neoplasms*/pathology
Female ; Mice ; Animals ; Humans ; Fallopian Tubes/metabolism ; Simvastatin/pharmacology ; Simvastatin/metabolism ; Simvastatin/therapeutic use ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Mevalonic Acid/metabolism ; Mevalonic Acid/therapeutic use ; Epithelial Cells/metabolism ; Carcinoma, Ovarian Epithelial/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effect of simvastatin on osteogenesis of the extremity bones in aging rats.
Autorzy:
Wang M; Department of Orthopedics, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Li H; Department of Orthopedics, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Tang J; Department of Orthopedics, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Xi Y; Department of Orthopedics, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Chen S; Department of Orthopedics, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Liu M; Department of Orthopedics, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
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Źródło:
Connective tissue research [Connect Tissue Res] 2023 Jan; Vol. 64 (1), pp. 64-74. Date of Electronic Publication: 2022 Jul 11.
Typ publikacji:
Journal Article
MeSH Terms:
Simvastatin*/pharmacology
Osteoporosis*/drug therapy
Rats ; Animals ; Osteogenesis ; Rats, Sprague-Dawley ; Bone Density ; Osteocalcin ; Lower Extremity ; Aging
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Attenuation of estrogen and its receptors in the post-menopausal stage exacerbates dyslipidemia and leads to cognitive impairment.
Autorzy:
Meng Q; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Chao Y; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Zhang S; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Ding X; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Feng H; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Zhang C; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Liu B; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Zhu W; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Li Y; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Zhang Q; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Tong H; Department of Pharmacy, Jiangsu Province Hospital of Integrated of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, China.
Wu L; Department of Cardiovascular, Jiangsu Province Hospital of Integrated of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, China. .
Bian H; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China. .
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Źródło:
Molecular brain [Mol Brain] 2023 Nov 20; Vol. 16 (1), pp. 80. Date of Electronic Publication: 2023 Nov 20.
Typ publikacji:
Journal Article
MeSH Terms:
Estrogen Receptor alpha*/metabolism
Cognitive Dysfunction*/complications
Humans ; Mice ; Female ; Animals ; Estrogen Receptor beta/metabolism ; Postmenopause ; Estrogens/pharmacology ; Estradiol/pharmacology ; Simvastatin/pharmacology ; Simvastatin/therapeutic use ; Lipids
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer.
Autorzy:
Xie W; Translational medicine centre, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, P. R. China.; Department of Hepatobiliary Surgery, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, P. R. China.
Peng M; Central laboratory, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, P. R. China.
Liu Y; Hunan Provincial Clinical Research Centre for Oncoplastic Surgery, Hunan Cancer hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, Hunan, 410013, P. R. China.
Zhang B; Translational medicine centre, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, P. R. China.; Hunan Provincial Clinical Research Centre for Oncoplastic Surgery, Hunan Cancer hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, Hunan, 410013, P. R. China.
Yi L; Hunan Provincial Clinical Research Centre for Oncoplastic Surgery, Hunan Cancer hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, Hunan, 410013, P. R. China.
Long Y; Translational medicine centre, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, P. R. China. .; Hunan Provincial Clinical Research Centre for Oncoplastic Surgery, Hunan Cancer hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, Hunan, 410013, P. R. China. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2023 Nov 16; Vol. 21 (1), pp. 329. Date of Electronic Publication: 2023 Nov 16.
Typ publikacji:
Video-Audio Media; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Pyroptosis*
Colonic Neoplasms*/pathology
Mice ; Animals ; Humans ; Caspase 1/metabolism ; Reactive Oxygen Species/metabolism ; Simvastatin/pharmacology ; Mice, Nude ; HCT116 Cells ; Disease Models, Animal ; Phosphate-Binding Proteins/metabolism ; Pore Forming Cytotoxic Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Anti-inflammatory effect of simvastatin by impeding TNF-α and interleukin-1ß pathways: antiangiogenic activity of simvastatin and simvastatin-loaded silver nanoparticles.
Autorzy:
Buabeid M; College of Pharmacy and Health Sciences, Ajman University, Ajman, UAE.; Medical and Bio-allied Health Sciences Research Centre, Ajman University, Ajman, UAE.
Arafa EA; College of Pharmacy and Health Sciences, Ajman University, Ajman, UAE.; Medical and Bio-allied Health Sciences Research Centre, Ajman University, Ajman, UAE.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Yaseen HS; Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore, Pakistan.
Umar MI; Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore, Pakistan.
Murtaza G; Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore, Pakistan.
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Źródło:
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2022 Dec; Vol. 50 (1), pp. 208-217.
Typ publikacji:
Journal Article
MeSH Terms:
Metal Nanoparticles*
Simvastatin*/pharmacology
Anti-Inflammatory Agents/pharmacology ; Interleukins ; Silver/pharmacology ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Protective Effect of Simvastatin on the Systolic Function of the Heart in the Model of Acute Ischemia and Reperfusion Is Due to Inhibition of the RhoA Pathway and Independent of Reduction of MMP-2 Activity.
Autorzy:
Skrzypiec-Spring M; Department of Pharmacology, Wrocław Medical University, 50-345 Wrocław, Poland.
Sapa-Wojciechowska A; Department of Clinical Chemistry, Wrocław Medical University, 50-556 Wrocław, Poland.
Rak-Pasikowska A; Department of Clinical Chemistry, Wrocław Medical University, 50-556 Wrocław, Poland.
Kaczorowski M; Department of Clinical and Experimental Pathology, Wrocław Medical University, 50-556 Wrocław, Poland.
Bil-Lula I; Department of Clinical Chemistry, Wrocław Medical University, 50-556 Wrocław, Poland.
Hałoń A; Department of Clinical and Experimental Pathology, Wrocław Medical University, 50-556 Wrocław, Poland.
Szeląg A; Department of Pharmacology, Wrocław Medical University, 50-345 Wrocław, Poland.
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Źródło:
Biomolecules [Biomolecules] 2022 Sep 13; Vol. 12 (9). Date of Electronic Publication: 2022 Sep 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Matrix Metalloproteinase 2*/genetics
Matrix Metalloproteinase 2*/metabolism
Reperfusion Injury*/drug therapy
Simvastatin*/pharmacology
rho-Associated Kinases*/metabolism
Animals ; Myosin Light Chains/metabolism ; RNA, Messenger ; Rats ; Rats, Sprague-Dawley ; Troponin I/metabolism ; rho GTP-Binding Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An experimental medicine study of the effects of simvastatin on emotional processing, reward learning, verbal memory, and inflammation in healthy volunteers.
Autorzy:
De Giorgi R; Department of Psychiatry, University of Oxford, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, Oxfordshire, UK. .; Oxford Health NHS Foundation Trust, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, Oxfordshire, UK. .
Quinton AMG; Department of Psychiatry, University of Oxford, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, Oxfordshire, UK.
Waters S; Department of Psychiatry, University of Oxford, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, Oxfordshire, UK.
Cowen PJ; Department of Psychiatry, University of Oxford, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, Oxfordshire, UK.; Oxford Health NHS Foundation Trust, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, Oxfordshire, UK.
Harmer CJ; Department of Psychiatry, University of Oxford, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, Oxfordshire, UK.; Oxford Health NHS Foundation Trust, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, Oxfordshire, UK.
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2022 Aug; Vol. 239 (8), pp. 2635-2645. Date of Electronic Publication: 2022 May 05.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Biomedical Research*
Simvastatin*/pharmacology
Double-Blind Method ; Female ; Healthy Volunteers ; Humans ; Inflammation/drug therapy ; Reward ; Verbal Learning
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Statins and cognitive decline in patients with Alzheimer's and mixed dementia: a longitudinal registry-based cohort study.
Autorzy:
Petek B; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. .; Clinical Institute of Genomic Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia. .; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. .
Häbel H; Medical Statistics Unit, Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden.
Xu H; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Villa-Lopez M; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Faculty of Medicine, University Complutense of Madrid, Madrid, Spain.; Department of Neurology, University of Alberta Hospital, Edmonton, Canada.
Kalar I; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.; Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Hoang MT; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Maioli S; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.
Pereira JB; Division of Neuro, Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.
Mostafaei S; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Winblad B; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Aging and Inflammation Theme, Karolinska University Hospital, Stockholm, Sweden.
Gregoric Kramberger M; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.; Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Eriksdotter M; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Aging and Inflammation Theme, Karolinska University Hospital, Stockholm, Sweden.
Garcia-Ptacek S; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. .; Aging and Inflammation Theme, Karolinska University Hospital, Stockholm, Sweden. .
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2023 Dec 20; Vol. 15 (1), pp. 220. Date of Electronic Publication: 2023 Dec 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hydroxymethylglutaryl-CoA Reductase Inhibitors*/therapeutic use
Alzheimer Disease*/drug therapy
Alzheimer Disease*/epidemiology
Mixed Dementias*
Cognitive Dysfunction*/drug therapy
Cognitive Dysfunction*/epidemiology
Humans ; Female ; Aged ; Atorvastatin/therapeutic use ; Cohort Studies ; Longitudinal Studies ; Simvastatin/therapeutic use ; Cholesterol
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inhibitors of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Decrease the Growth, Ergosterol Synthesis and Generation of petite Mutants in Candida glabrata and Candida albicans .
Autorzy:
Andrade-Pavón D; Laboratorio de Biología Molecular de Bacterias y Levaduras, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala S/N, Col. Santo Tomás, Alc. Miguel Hidalgo, Ciudad de México 11340, Mexico.
Sánchez-Sandoval E; Core Facilities Department, Gothenburg University, Medicinaregatan 9 A-B, 41390 Göteborg, Sweden.
Tamariz J; Departamento de Química Orgánica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala S/N, Col. Santo Tomás, Alc. Miguel Hidalgo, Ciudad de México 11340, Mexico.
Ibarra JA; Laboratorio de Genética Microbiana, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala S/N, Col. Santo Tomás, Alc. Miguel Hidalgo, Ciudad de México 11340, Mexico.
Hernández-Rodríguez C; Laboratorio de Biología Molecular de Bacterias y Levaduras, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala S/N, Col. Santo Tomás, Alc. Miguel Hidalgo, Ciudad de México 11340, Mexico.
Villa-Tanaca L; Laboratorio de Biología Molecular de Bacterias y Levaduras, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala S/N, Col. Santo Tomás, Alc. Miguel Hidalgo, Ciudad de México 11340, Mexico.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 28; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 28.
Typ publikacji:
Journal Article
MeSH Terms:
Hydroxymethylglutaryl-CoA Reductase Inhibitors*/pharmacology
Candida albicans ; Candida glabrata/genetics ; Antifungal Agents/pharmacology ; Simvastatin/pharmacology ; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent ; Oxidoreductases ; Ergosterol/metabolism ; Microbial Sensitivity Tests
Czasopismo naukowe
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Tytuł:
Does the choice of applied physiologically-based pharmacokinetics platform matter? A case study on simvastatin disposition and drug-drug interaction.
Autorzy:
Prieto Garcia L; Department of Pharmaceutical Bioscience, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden.; DMPK, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Lundahl A; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Ahlström C; DMPK, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Vildhede A; DMPK, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Lennernäs H; Department of Pharmaceutical Bioscience, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden.
Sjögren E; Department of Pharmaceutical Bioscience, Translational Drug Discovery and Development, Uppsala University, Uppsala, Sweden.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2022 Sep; Vol. 11 (9), pp. 1194-1209. Date of Electronic Publication: 2022 Jul 16.
Typ publikacji:
Journal Article
MeSH Terms:
Models, Biological*
Simvastatin*
ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Computer Simulation ; Drug Interactions ; Humans ; Neoplasm Proteins ; Pharmacokinetics
Czasopismo naukowe
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Tytuł:
Association of cytochromes P450 3A4*22 and 3A5*3 genotypes and polymorphism with response to simvastatin in hypercholesterolemia patients.
Autorzy:
Elalem EG; Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Jelani M; Department of Genetic Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.; Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.
Khedr A; Department of Analytical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Ahmad A; Health Information Technology Department, Jeddah Community College, King Abdulaziz University, Jeddah, Saudi Arabia.
Alaama TY; Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Alaama MN; Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Al-Kreathy HM; Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Damanhouri ZA; Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
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Źródło:
PloS one [PLoS One] 2022 Jul 15; Vol. 17 (7), pp. e0260824. Date of Electronic Publication: 2022 Jul 15 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Cytochrome P-450 CYP3A*/genetics
Hydroxymethylglutaryl-CoA Reductase Inhibitors*/therapeutic use
Hypercholesterolemia*/drug therapy
Hypercholesterolemia*/genetics
Simvastatin*/pharmacokinetics
Simvastatin*/therapeutic use
Cholesterol, LDL/genetics ; Genotype ; Humans ; Polymorphism, Single Nucleotide
Czasopismo naukowe
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Tytuł:
Characterizing the impact of simvastatin co-treatment of cell specific TCDD-induced gene expression and systemic toxicity.
Autorzy:
Jurgelewicz A; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.; Institute for Integrative Toxicological Sciences, Michigan State University, East Lansing, MI, USA.
Nault R; Institute for Integrative Toxicological Sciences, Michigan State University, East Lansing, MI, USA.; Department of Biochemistry and Molecular Biology, Michigan State University, 602 Wilson Rd, East Lansing, MI, 48824, USA.
Harkema J; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.; Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, USA.
Zacharewski TR; Institute for Integrative Toxicological Sciences, Michigan State University, East Lansing, MI, USA.; Department of Biochemistry and Molecular Biology, Michigan State University, 602 Wilson Rd, East Lansing, MI, 48824, USA.
LaPres JJ; Institute for Integrative Toxicological Sciences, Michigan State University, East Lansing, MI, USA. .; Department of Biochemistry and Molecular Biology, Michigan State University, 602 Wilson Rd, East Lansing, MI, 48824, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 03; Vol. 13 (1), pp. 16598. Date of Electronic Publication: 2023 Oct 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Polychlorinated Dibenzodioxins*/toxicity
Non-alcoholic Fatty Liver Disease*/chemically induced
Non-alcoholic Fatty Liver Disease*/genetics
Non-alcoholic Fatty Liver Disease*/metabolism
Humans ; Mice ; Male ; Animals ; Simvastatin/pharmacology ; Simvastatin/metabolism ; Liver/metabolism ; Receptors, Aryl Hydrocarbon/metabolism ; Gene Expression ; Cholesterol/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Low dosage combination treatment with metformin and simvastatin inhibits obesity-promoted pancreatic cancer development in male KrasG12D mice.
Autorzy:
Teper Y; Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Ye L; Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Waldron RT; Pancreatic Research Group, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Lugea A; Pancreatic Research Group, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Sun X; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Sinnett-Smith J; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Hines OJ; Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Pandol SJ; Pancreatic Research Group, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Rozengurt E; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Eibl G; Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Sep 26; Vol. 13 (1), pp. 16144. Date of Electronic Publication: 2023 Sep 26.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Pancreatic Neoplasms*/drug therapy
Pancreatic Neoplasms*/prevention & control
Carcinoma, Pancreatic Ductal*/drug therapy
Carcinoma, Pancreatic Ductal*/prevention & control
Adenocarcinoma in Situ*
Male ; Female ; Animals ; Mice ; Simvastatin/pharmacology ; Simvastatin/therapeutic use ; Obesity/complications ; Obesity/drug therapy ; Pancreatic Neoplasms
Czasopismo naukowe
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Tytuł:
Effect of Roxadustat on the Pharmacokinetics of Simvastatin, Rosuvastatin, and Atorvastatin in Healthy Subjects: Results From 3 Phase 1, Open-Label, 1-Sequence, Crossover Studies.
Autorzy:
Groenendaal-van de Meent D; Astellas Pharma Europe B.V., Leiden, The Netherlands.
den Adel M; Astellas Pharma Europe B.V., Leiden, The Netherlands.
Kerbusch V; PharmAspire B.V., Wijchen, The Netherlands.
van Dijk J; Astellas Pharma Europe B.V., Leiden, The Netherlands.
Shibata T; Astellas Pharma, Inc., Tokyo, Japan.
Kato K; Astellas Pharma, Inc., Tokyo, Japan.
Schaddelee M; Astellas Pharma Europe B.V., Leiden, The Netherlands.
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Źródło:
Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2022 Apr; Vol. 11 (4), pp. 486-501. Date of Electronic Publication: 2022 Feb 19.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial
MeSH Terms:
Neoplasm Proteins*
Simvastatin*/adverse effects
Simvastatin*/pharmacokinetics
ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Atorvastatin/adverse effects ; Atorvastatin/pharmacokinetics ; Cross-Over Studies ; Glycine/analogs & derivatives ; Healthy Volunteers ; Humans ; Isoquinolines ; Rosuvastatin Calcium/adverse effects ; Rosuvastatin Calcium/pharmacokinetics
Czasopismo naukowe
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