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Tytuł:
Bis(Disulfide)-Bridged Somatostatin-14 Analogs and Their [ In]In-Radioligands: Synthesis and Preclinical Profile.
Autorzy:
Tatsi A; Molecular Radiopharmacy, INRaSTES, NCSR 'Demokritos', GR-15341 Athens, Greece.; Department of Pharmacy, University of Patras, GR-26500 Patras, Greece.
Maina T; Molecular Radiopharmacy, INRaSTES, NCSR 'Demokritos', GR-15341 Athens, Greece.
Waser B; Institute of Pathology, University of Berne, CH-3010 Berne, Switzerland.
Krenning EP; Cyclotron Rotterdam BV, Erasmus MC, 3015 Rotterdam, The Netherlands.
de Jong M; Department of Radiology and Nuclear Medicine, Erasmus MC, 3015 Rotterdam, The Netherlands.
Reubi JC; Institute of Pathology, University of Berne, CH-3010 Berne, Switzerland.
Cordopatis P; Department of Pharmacy, University of Patras, GR-26500 Patras, Greece.
Nock BA; Molecular Radiopharmacy, INRaSTES, NCSR 'Demokritos', GR-15341 Athens, Greece.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 05; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
Neoplasms*
Somatostatin*/metabolism
Animals ; Humans ; Mice ; HEK293 Cells ; Receptors, Somatostatin/metabolism ; Tissue Distribution
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Somatostatin and Somatostatin Receptors in Tumour Biology.
Autorzy:
Kumar U; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 28; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 28.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Receptors, Somatostatin*
Neoplasms*/drug therapy
Humans ; Somatostatin ; Growth Hormone ; Biology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Meningiomas and Somatostatin Analogs: A Systematic Scoping Review on Current Insights and Future Perspectives.
Autorzy:
Tollefsen SE; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.
Solheim O; Department of Neurosurgery, St. Olavs Hospital, Trondheim University Hospital, 7030 Trondheim, Norway.; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Mjønes P; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.; Department of Pathology, St. Olavs Hospital, Trondheim University Hospital, 7006 Trondheim, Norway.
Torp SH; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.; Department of Pathology, St. Olavs Hospital, Trondheim University Hospital, 7006 Trondheim, Norway.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 01; Vol. 24 (5). Date of Electronic Publication: 2023 Mar 01.
Typ publikacji:
Journal Article; Systematic Review
MeSH Terms:
Meningeal Neoplasms*/pathology
Meningioma*/pathology
Somatostatin*/analogs & derivatives
Humans ; Neoplasm Recurrence, Local/drug therapy ; Octreotide/therapeutic use ; Randomized Controlled Trials as Topic ; Receptors, Somatostatin
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Molecular simulations of SSTR2 dynamics and interaction with ligands.
Autorzy:
Gervasoni S; Department of Physics, University of Cagliari, 09042, Monserrato (Cagliari), Italy.
Guccione C; Department of Physics, University of Cagliari, 09042, Monserrato (Cagliari), Italy.
Fanti V; Department of Physics, University of Cagliari, 09042, Monserrato (Cagliari), Italy.; Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari, 09042, Monserrato (Cagliari), Italy.
Bosin A; Department of Physics, University of Cagliari, 09042, Monserrato (Cagliari), Italy.
Cappellini G; Department of Physics, University of Cagliari, 09042, Monserrato (Cagliari), Italy.
Golosio B; Department of Physics, University of Cagliari, 09042, Monserrato (Cagliari), Italy.; Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari, 09042, Monserrato (Cagliari), Italy.
Ruggerone P; Department of Physics, University of Cagliari, 09042, Monserrato (Cagliari), Italy.
Malloci G; Department of Physics, University of Cagliari, 09042, Monserrato (Cagliari), Italy. .
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Źródło:
Scientific reports [Sci Rep] 2023 Mar 23; Vol. 13 (1), pp. 4768. Date of Electronic Publication: 2023 Mar 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, Somatostatin*/metabolism
Neuroendocrine Tumors*/drug therapy
Humans ; Octreotide/therapeutic use ; Somatostatin/metabolism ; GTP-Binding Proteins/metabolism ; Ligands
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In patients with well-differentiated neuroendocrine tumours, there is no apparent benefit of somatostatin analogues after disease control by peptide receptor radionuclide therapy.
Autorzy:
Syguła A; Department of Nuclear Medicine and Endocrine Oncology, Gliwice Branch, Maria Sklodowska-Curie National Research Institute of Oncology, Wybrzeże Armii Krajowej 16, 44-101, Gliwice, Poland.
Ledwon A; Department of Nuclear Medicine and Endocrine Oncology, Gliwice Branch, Maria Sklodowska-Curie National Research Institute of Oncology, Wybrzeże Armii Krajowej 16, 44-101, Gliwice, Poland.
Hasse-Lazar K; Department of Nuclear Medicine and Endocrine Oncology, Gliwice Branch, Maria Sklodowska-Curie National Research Institute of Oncology, Wybrzeże Armii Krajowej 16, 44-101, Gliwice, Poland.
Jurecka-Lubieniecka B; Department of Nuclear Medicine and Endocrine Oncology, Gliwice Branch, Maria Sklodowska-Curie National Research Institute of Oncology, Wybrzeże Armii Krajowej 16, 44-101, Gliwice, Poland.
Michalik B; Department of Nuclear Medicine and Endocrine Oncology, Gliwice Branch, Maria Sklodowska-Curie National Research Institute of Oncology, Wybrzeże Armii Krajowej 16, 44-101, Gliwice, Poland.
Paliczka-Cieślik E; Department of Nuclear Medicine and Endocrine Oncology, Gliwice Branch, Maria Sklodowska-Curie National Research Institute of Oncology, Wybrzeże Armii Krajowej 16, 44-101, Gliwice, Poland.
Zeman M; The Oncologic and Reconstructive Surgery Clinic, Gliwice Branch, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland.
Chmielik E; Tumor Pathology Department, Gliwice Branch, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland.
Sczasny J; Radiology and Diagnostic Imaging Department, Gliwice Branch, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland.
Jarzab B; Department of Nuclear Medicine and Endocrine Oncology, Gliwice Branch, Maria Sklodowska-Curie National Research Institute of Oncology, Wybrzeże Armii Krajowej 16, 44-101, Gliwice, Poland.
Handkiewicz-Junak D; Department of Nuclear Medicine and Endocrine Oncology, Gliwice Branch, Maria Sklodowska-Curie National Research Institute of Oncology, Wybrzeże Armii Krajowej 16, 44-101, Gliwice, Poland. .
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Źródło:
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2022 Sep; Vol. 49 (11), pp. 3841-3851. Date of Electronic Publication: 2022 May 03.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Neuroendocrine Tumors*/pathology
Neuroendocrine Tumors*/radiotherapy
Somatostatin*/analogs & derivatives
Somatostatin*/therapeutic use
Humans ; Octreotide/therapeutic use ; Prospective Studies ; Radioisotopes ; Receptors, Somatostatin ; Retrospective Studies ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
EANM dosimetry committee recommendations for dosimetry of 177Lu-labelled somatostatin-receptor- and PSMA-targeting ligands.
Autorzy:
Sjögreen Gleisner K; Medical Radiation Physics, Clinical Sciences Lund, Lund University, Lund, Sweden. katarina.sjogreen_.
Chouin N; Université de Nantes, CNRS, Inserm, Oniris, CRCINA, Nantes, France.
Gabina PM; Department of Medical Physics and Radiation Protection, Gurutzeta-Cruces University Hospital/Biocruces Health Research Institute, Barakaldo, Spain.; Department of Applied Physics, Faculty of Engineering, UPV/EHU, Bilbao, Spain.
Cicone F; Department of Experimental and Clinical Medicine, Neuroscience Research Centre, PET/RM Unit, 'Magna Graecia' University of Catanzaro, Catanzaro, Italy.; Nuclear Medicine Unit, University Hospital 'Mater Domini, Catanzaro, Italy.
Gnesin S; Institute of Radiation Physics, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Stokke C; Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.; Department of Physics, University of Oslo, Oslo, Norway.
Konijnenberg M; Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Medical Imaging, Radboud University Medical Center, Nijmegen, the Netherlands.
Cremonesi M; Radiation Research Unit, Department of Medical Imaging and Radiation Sciences, Istituto Europeo di Oncologia, IRCCS, Milan, Italy.
Verburg FA; Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Bernhardt P; Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.; Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden.
Eberlein U; Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Gear J; Joint department of Physics, Royal Marsden NHSFT and Institute of Cancer Research, Sutton, UK.
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Źródło:
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2022 May; Vol. 49 (6), pp. 1778-1809. Date of Electronic Publication: 2022 Mar 14.
Typ publikacji:
Journal Article
MeSH Terms:
Radiation Injuries*
Receptors, Somatostatin*
Humans ; Ligands ; Lutetium/therapeutic use ; Male ; Prostate-Specific Antigen ; Radioisotopes ; Radiopharmaceuticals/adverse effects ; Somatostatin
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Somatostatin receptor 2 (SSTR2) expression is associated with better clinical outcome and prognosis in rectal neuroendocrine tumors.
Autorzy:
Kim JY; Department of Pathology, Chung-Ang University Hospital, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.
Kim J; Department of Pathology, Gil Medical Center, Gachon University College of Medicine, Inchon, Republic of Korea.
Kim YI; Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Yang DH; Departments of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Yoo C; Departments of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Park IJ; Departments of Colon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Ryoo BY; Departments of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Ryu JS; Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Hong SM; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. .
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 19; Vol. 14 (1), pp. 4047. Date of Electronic Publication: 2024 Feb 19.
Typ publikacji:
Journal Article
MeSH Terms:
Intestinal Neoplasms*
Neuroendocrine Tumors*/genetics
Neuroendocrine Tumors*/pathology
Pancreatic Neoplasms*
Rectal Neoplasms*/genetics
Rectal Neoplasms*/surgery
Rectal Neoplasms*/drug therapy
Stomach Neoplasms*
Humans ; Prognosis ; Receptors, Somatostatin/genetics ; Receptors, Somatostatin/metabolism ; Somatostatin/metabolism
SCR Disease Name:
Gastro-enteropancreatic neuroendocrine tumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In-vivo inhibition of neutral endopeptidase 1 results in higher absorbed tumor doses of [Lu]Lu-PP-F11N in humans: the lumed phase 0b study.
Autorzy:
Rottenburger, Christof (AUTHOR)
Hentschel, Michael (AUTHOR)
Fürstner, Markus (AUTHOR)
McDougall, Lisa (AUTHOR)
Kottoros, Danijela (AUTHOR)
Kaul, Felix (AUTHOR)
Mansi, Rosalba (AUTHOR)
Fani, Melpomeni (AUTHOR)
Vija, A. Hans (AUTHOR)
Schibli, Roger (AUTHOR)
Geistlich, Susanne (AUTHOR)
Behe, Martin (AUTHOR)
Christ, Emanuel R. (AUTHOR)
Wild, Damian (AUTHOR)
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Źródło:
EJNMMI Research. 4/6/2024, Vol. 14 Issue 1, p1-13. 13p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons.
Autorzy:
Takács, Virág (AUTHOR)
Bardóczi, Zsuzsanna (AUTHOR)
Orosz, Áron (AUTHOR)
Major, Abel (AUTHOR)
Tar, Luca (AUTHOR)
Berki, Péter (AUTHOR)
Papp, Péter (AUTHOR)
Mayer, Márton I. (AUTHOR)
Sebők, Hunor (AUTHOR)
Zsolt, Luca (AUTHOR)
Sos, Katalin E. (AUTHOR)
Káli, Szabolcs (AUTHOR)
Freund, Tamás F. (AUTHOR)
Nyiri, Gábor (AUTHOR)
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Źródło:
PLoS Biology. 3/12/2024, Vol. 22 Issue 3, p1-54. 54p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Antitumoral and Anti-inflammatory Roles of Somatostatin and Its Analogs in Hepatocellular Carcinoma.
Autorzy:
Periferakis A; Department of Physiology, The 'Carol Davila' University of Medicine and Pharmacy, Bucharest 050474, Romania.
Tsigas G; Department of Physiology, The 'Carol Davila' University of Medicine and Pharmacy, Bucharest 050474, Romania.
Periferakis AT; Department of Physiology, The 'Carol Davila' University of Medicine and Pharmacy, Bucharest 050474, Romania.
Badarau IA; Department of Physiology, The 'Carol Davila' University of Medicine and Pharmacy, Bucharest 050474, Romania.
Scheau AE; Department of Radiology and Medical Imaging, Fundeni Clinical Institute, Bucharest 022328, Romania.
Tampa M; Department of Dermatology, The 'Carol Davila' University of Medicine and Pharmacy, Bucharest 020021, Romania.; Department of Dermatology, Victor Babes Clinical Hospital for Infectious Diseases, Bucharest 030303, Romania.
Georgescu SR; Department of Dermatology, The 'Carol Davila' University of Medicine and Pharmacy, Bucharest 020021, Romania.; Department of Dermatology, Victor Babes Clinical Hospital for Infectious Diseases, Bucharest 030303, Romania.
Didilescu AC; Division of Embryology, Faculty of Dental Medicine, The 'Carol Davila' University of Medicine and Pharmacy, Bucharest 050474, Romania.
Scheau C; Department of Physiology, The 'Carol Davila' University of Medicine and Pharmacy, Bucharest 050474, Romania.
Caruntu C; Department of Physiology, The 'Carol Davila' University of Medicine and Pharmacy, Bucharest 050474, Romania.; 'Prof. N.C. Paulescu' National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest 011233, Romania.
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Źródło:
Analytical cellular pathology (Amsterdam) [Anal Cell Pathol (Amst)] 2021 Nov 27; Vol. 2021, pp. 1840069. Date of Electronic Publication: 2021 Nov 27 (Print Publication: 2021).
Typ publikacji:
Journal Article; Review
MeSH Terms:
Anti-Inflammatory Agents/*therapeutic use
Antineoplastic Agents/*therapeutic use
Carcinoma, Hepatocellular/*drug therapy
Liver Neoplasms/*drug therapy
Somatostatin/*therapeutic use
Animals ; Apoptosis/drug effects ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation/drug effects ; Cytokines/antagonists & inhibitors ; Cytokines/metabolism ; Humans ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/metabolism ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Receptors, Somatostatin/metabolism ; Somatostatin/analogs & derivatives
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chromatin accessibility differences between alpha, beta, and delta cells identifies common and cell type-specific enhancers.
Autorzy:
Mawla AM; Department of Neurobiology, Physiology & Behavior, College of Biological Sciences, University of California, One Shields Avenue, Davis, CA, 95616, USA.
van der Meulen T; Department of Neurobiology, Physiology & Behavior, College of Biological Sciences, University of California, One Shields Avenue, Davis, CA, 95616, USA.
Huising MO; Department of Neurobiology, Physiology & Behavior, College of Biological Sciences, University of California, One Shields Avenue, Davis, CA, 95616, USA. .; Department of Physiology and Membrane Biology, School of Medicine, University of California, One Shields Avenue, Davis, CA, 95616, USA. .
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Źródło:
BMC genomics [BMC Genomics] 2023 Apr 17; Vol. 24 (1), pp. 202. Date of Electronic Publication: 2023 Apr 17.
Typ publikacji:
Journal Article
MeSH Terms:
Chromatin*/genetics
Chromatin*/metabolism
Enhancer Elements, Genetic*
Islets of Langerhans*/metabolism
Somatostatin-Secreting Cells*/metabolism
Animals ; Mice ; Glucagon/genetics ; Glucagon/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration.
Autorzy:
Rayala R; Department of Chemistry and Biochemistry, Charles E. Schmidt College of Science, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA.
Tiller A; Department of Chemistry and Biochemistry, Charles E. Schmidt College of Science, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA.
Majumder SA; Department of Pharmacodynamics, School of Pharmacy, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA.
Stacy HM; Department of Pharmacodynamics, School of Pharmacy, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA.
Eans SO; Department of Pharmacodynamics, School of Pharmacy, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA.
Nedovic A; Department of Chemistry and Biochemistry, Charles E. Schmidt College of Science, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA.
McLaughlin JP; Department of Pharmacodynamics, School of Pharmacy, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA.
Cudic P; Department of Chemistry and Biochemistry, Charles E. Schmidt College of Science, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Feb 15; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 15.
Typ publikacji:
Journal Article
MeSH Terms:
Solid-Phase Synthesis Techniques*
Somatostatin*/pharmacology
Mice ; Animals ; Administration, Intranasal ; Receptors, Opioid, mu ; Peptides/pharmacology ; Morphine/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Somatostatin contributes to long-term potentiation at excitatory synapses onto hippocampal somatostatinergic interneurons.
Autorzy:
Racine AS; Centre for Interdisciplinary Research on Brain and Learning, Research Group on the Central Nervous System, Department of Neurosciences, Université de Montréal, P.O. Box 6128, Station Downtown, Montreal, QC, H3C 3J7, Canada.
Michon FX; Centre for Interdisciplinary Research on Brain and Learning, Research Group on the Central Nervous System, Department of Neurosciences, Université de Montréal, P.O. Box 6128, Station Downtown, Montreal, QC, H3C 3J7, Canada.
Laplante I; Centre for Interdisciplinary Research on Brain and Learning, Research Group on the Central Nervous System, Department of Neurosciences, Université de Montréal, P.O. Box 6128, Station Downtown, Montreal, QC, H3C 3J7, Canada.
Lacaille JC; Centre for Interdisciplinary Research on Brain and Learning, Research Group on the Central Nervous System, Department of Neurosciences, Université de Montréal, P.O. Box 6128, Station Downtown, Montreal, QC, H3C 3J7, Canada. .
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Źródło:
Molecular brain [Mol Brain] 2021 Aug 24; Vol. 14 (1), pp. 130. Date of Electronic Publication: 2021 Aug 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CA1 Region, Hippocampal/*drug effects
Excitatory Postsynaptic Potentials/*drug effects
GABAergic Neurons/*drug effects
Interneurons/*drug effects
Long-Term Potentiation/*drug effects
Somatostatin/*physiology
Synapses/*drug effects
Animals ; Bacterial Proteins ; Cysteamine/pharmacology ; Female ; GABA-A Receptor Antagonists/pharmacology ; GABAergic Neurons/metabolism ; Gene Knock-In Techniques ; Genes, Reporter ; Humans ; Interneurons/metabolism ; Luminescent Proteins ; Male ; Memory/physiology ; Mice ; Mice, Transgenic ; Peptides, Cyclic/pharmacology ; Receptors, Metabotropic Glutamate/physiology ; Receptors, N-Methyl-D-Aspartate/physiology ; Receptors, Somatostatin/drug effects ; Receptors, Somatostatin/physiology ; Somatostatin/pharmacology ; Synapses/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Somatostatin receptor ligands suppressed proliferation and lipogenesis in 3T3-L1 preadipocytes.
Autorzy:
Zhao Z; State Key Laboratory of Bioactive Substrate and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Gong F; Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Duan L; Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Lv X; Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wu H; State Key Laboratory of Bioactive Substrate and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Tang Y; Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhu H; Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chen X; State Key Laboratory of Bioactive Substrate and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2022 Sep; Vol. 131 (3), pp. 174-188. Date of Electronic Publication: 2022 Jul 01.
Typ publikacji:
Journal Article
MeSH Terms:
Ligands*
Lipogenesis*/drug effects
Lipogenesis*/physiology
Receptors, Somatostatin*/metabolism
Somatostatin*/analogs & derivatives
Somatostatin*/pharmacology
3T3-L1 Cells/drug effects ; 3T3-L1 Cells/metabolism ; Adipocytes/drug effects ; Adipocytes/metabolism ; Animals ; CCAAT-Enhancer-Binding Protein-alpha/genetics ; CCAAT-Enhancer-Binding Protein-alpha/metabolism ; Cell Differentiation ; Cell Proliferation ; Mice ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Selective dopamine D2 receptor deletion from Nkx6.2 expressing cells causes impaired cognitive, motivation and anxiety phenotypes in mice.
Autorzy:
Bechelli L; Instituto de Biología y Medicina Experimental (IBYME). Fundación IBYME., Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)., Vuelta de Obligado 2490, C1428ADN, Ciudad Autónoma de Buenos Aires, Argentina.
Tomasella E; Instituto de Biología y Medicina Experimental (IBYME). Fundación IBYME., Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)., Vuelta de Obligado 2490, C1428ADN, Ciudad Autónoma de Buenos Aires, Argentina.
Cardoso SL; Instituto de Biología y Medicina Experimental (IBYME). Fundación IBYME., Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)., Vuelta de Obligado 2490, C1428ADN, Ciudad Autónoma de Buenos Aires, Argentina.
Belmonte M; Instituto de Biología y Medicina Experimental (IBYME). Fundación IBYME., Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)., Vuelta de Obligado 2490, C1428ADN, Ciudad Autónoma de Buenos Aires, Argentina.
Gelman DM; Instituto de Biología y Medicina Experimental (IBYME). Fundación IBYME., Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)., Vuelta de Obligado 2490, C1428ADN, Ciudad Autónoma de Buenos Aires, Argentina. .; Universidad Argentina de la Empresa (UADE), Lima 757, C1073AAO, Ciudad Autónoma de Buenos Aires, Argentina. .
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 09; Vol. 13 (1), pp. 19473. Date of Electronic Publication: 2023 Nov 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Motivation*
Parvalbumins*/metabolism
Animals ; Mice ; Anxiety/genetics ; Cognition ; Interneurons/metabolism ; Mice, Transgenic ; Phenotype ; Receptors, Dopamine D2/genetics ; Receptors, Dopamine D2/metabolism ; Somatostatin/genetics ; Somatostatin/metabolism
Czasopismo naukowe
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Tytuł:
Phase 1 Study of No-Carrier Added 177Lu-DOTATATE (SNU-KB-01) in Patients with Somatostatin Receptor-Positive Neuroendocrine Tumors: The First Clinical Trial of Peptide Receptor Radionuclide Therapy in Korea.
Autorzy:
Ryoo HG; Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.; Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Suh M; Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.
Kang KW; Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.; Cancer Research Institute, Seoul National University, Seoul, Korea.
Lee DW; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Han SW; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Cheon GJ; Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.; Cancer Research Institute, Seoul National University, Seoul, Korea.
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Źródło:
Cancer research and treatment [Cancer Res Treat] 2023 Jan; Vol. 55 (1), pp. 334-343. Date of Electronic Publication: 2022 Apr 22.
Typ publikacji:
Clinical Trial, Phase I; Journal Article
MeSH Terms:
Receptors, Somatostatin*
Neuroendocrine Tumors*/radiotherapy
Neuroendocrine Tumors*/pathology
Humans ; Radioisotopes/adverse effects ; Republic of Korea
Czasopismo naukowe
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Tytuł:
Primary follicular dendritic cell sarcoma of the kidney – a case report of a rare tumor with emphasis on diagnostic pitfalls.
Autorzy:
Pancsa, Tamás (AUTHOR)
Dénes, Borbála (AUTHOR)
Somorácz, Áron (AUTHOR)
Kelemen, Dóra (AUTHOR)
Salamon, Ferenc (AUTHOR)
Sánta, Fanni (AUTHOR)
Kuthi, Levente (AUTHOR)
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Źródło:
Diagnostic Pathology. 1/31/2024, Vol. 19, p1-6. 6p.
Czasopismo naukowe
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Tytuł:
Methodology of the SORENTO clinical trial: a prospective, randomised, active-controlled phase 3 trial assessing the efficacy and safety of high exposure octreotide subcutaneous depot (CAM2029) in patients with GEP-NET.
Autorzy:
Singh, Simron (AUTHOR)
Ferone, Diego (AUTHOR)
Capdevila, Jaume (AUTHOR)
Chan, Jennifer Ang (AUTHOR)
de Herder, Wouter W. (AUTHOR)
Halperin, Daniel (AUTHOR)
Mailman, Josh (AUTHOR)
Hellström, Lisa (AUTHOR)
Liedman, Hanna (AUTHOR)
Svedberg, Agneta (AUTHOR)
Tiberg, Fredrik (AUTHOR)
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Źródło:
Trials. 1/16/2024, Vol. 25 Issue 1, p1-13. 13p.
Czasopismo naukowe
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Tytuł:
Radiomics and Artificial Intelligence in Radiotheranostics: A Review of Applications for Radioligands Targeting Somatostatin Receptors and Prostate-Specific Membrane Antigens.
Autorzy:
Yazdani, Elmira (AUTHOR)
Geramifar, Parham (AUTHOR)
Karamzade-Ziarati, Najme (AUTHOR)
Sadeghi, Mahdi (AUTHOR)
Amini, Payam (AUTHOR)
Rahmim, Arman (AUTHOR)
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Źródło:
Diagnostics (2075-4418). Jan2024, Vol. 14 Issue 2, p181. 39p.
Czasopismo naukowe
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Wyświetlanie 1-20 z 24449

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