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Tytuł :
Differential Expression Levels of Sox9 in Early Neocortical Radial Glial Cells Regulate the Decision between Stem Cell Maintenance and Differentiation.
Autorzy :
Fabra-Beser J; BIOTECMED Institute, Universidad de Valencia, Burjassot, 46100 Valencia, Spain.
Alves Medeiros de Araujo J; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.; Brain Institute, Federal University of Rio Grande do Norte, RN 59056-450, Natal, Brazil.
Marques-Coelho D; Brain Institute, Federal University of Rio Grande do Norte, RN 59056-450, Natal, Brazil.; Bioinformatics Multidisciplinary Environment, IMD, Federal University of Rio Grande do Norte, RN 59078-400, Natal, Brazil.
Goff LA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Costa MR; Brain Institute, Federal University of Rio Grande do Norte, RN 59056-450, Natal, Brazil.; Institut National de la Santé et de la Recherche Médicale U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liés au vieillissement, DISTALZ, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, 59000 Lille, France.
Müller U; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Gil-Sanz C; BIOTECMED Institute, Universidad de Valencia, Burjassot, 46100 Valencia, Spain .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2021 Aug 18; Vol. 41 (33), pp. 6969-6986. Date of Electronic Publication: 2021 Jul 15.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Self Renewal/*genetics
Ependymoglial Cells/*cytology
Gene Expression Regulation, Developmental/*genetics
Neocortex/*cytology
Nerve Tissue Proteins/*physiology
Neurogenesis/*genetics
SOX9 Transcription Factor/*physiology
Animals ; Cell Cycle/genetics ; Electroporation ; Ependymoglial Cells/metabolism ; Female ; Genes, Reporter ; Genetic Vectors/administration & dosage ; Injections, Intraventricular ; Mice ; Mice, Inbred C57BL ; Neocortex/embryology ; Neocortex/growth & development ; Nerve Tissue Proteins/biosynthesis ; Nerve Tissue Proteins/genetics ; Neuroglia/cytology ; Neurons/cytology ; Pregnancy ; Promoter Regions, Genetic/genetics ; SOX9 Transcription Factor/biosynthesis ; SOX9 Transcription Factor/genetics ; Single-Cell Analysis ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Downregulation of MicroRNA-495 Alleviates IL-1β Responses among Chondrocytes by Preventing SOX9 Reduction.
Autorzy :
Joung S; Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea.; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
Yoon DS; Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea.
Cho S; Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea.; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
Ko EA; Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea.
Lee KM; Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea.; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.
Park KH; Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea.
Lee JW; Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea.; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.
Kim SH; Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea.; Arthroscopy and Joint Research Institute, Yonsei University College of Medicine, Seoul, Korea.; Department of Orthopedic Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. .
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Źródło :
Yonsei medical journal [Yonsei Med J] 2021 Jul; Vol. 62 (7), pp. 650-659.
Typ publikacji :
Journal Article
MeSH Terms :
Chondrocytes*/metabolism
Interleukin-1beta*/metabolism
MicroRNAs*/genetics
SOX9 Transcription Factor*/genetics
SOX9 Transcription Factor*/metabolism
Cells, Cultured ; Down-Regulation ; Humans
Czasopismo naukowe
Tytuł :
Serum lncRNA-ANRIL and SOX9 expression levels in glioma patients and their relationship with poor prognosis.
Autorzy :
Sun Y; Department of Neurosurgery, Guangrao County People's Hospital, No. 180 Huayuan Road, Dongying, Guangrao County, 257300, P.R. China.
Jing Y; Department of Neurosurgery, The Second People's Hospital Of Dongying, Dongying, 257335, P.R. China.
Zhang Y; Department of Neurosurgery, Guangrao County People's Hospital, No. 180 Huayuan Road, Dongying, Guangrao County, 257300, P.R. China. .
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Źródło :
World journal of surgical oncology [World J Surg Oncol] 2021 Sep 23; Vol. 19 (1), pp. 287. Date of Electronic Publication: 2021 Sep 23.
Typ publikacji :
Journal Article
MeSH Terms :
Glioma*/diagnosis
Glioma*/genetics
RNA, Long Noncoding*/genetics
SOX9 Transcription Factor*/genetics
Apoptosis ; Cell Proliferation ; Humans ; Prognosis
Czasopismo naukowe
Tytuł :
Olfactory bulb astrocytes mediate sensory circuit processing through Sox9 in the mouse brain.
Autorzy :
Ung K; Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.
Huang TW; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Lozzi B; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Woo J; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Hanson E; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Pekarek B; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Tepe B; Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.
Sardar D; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Cheng YT; Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Liu G; Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.; Medical Scientist Training Program, Baylor College of Medicine, Houston, TX, USA.
Deneen B; Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA. .; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA. .; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA. .; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA. .
Arenkiel BR; Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA. .; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. .; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA. .; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 01; Vol. 12 (1), pp. 5230. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*metabolism
Olfactory Bulb/*physiology
SOX9 Transcription Factor/*metabolism
Sensation/*physiology
Animals ; Excitatory Amino Acid Transporter 2/genetics ; Excitatory Amino Acid Transporter 2/metabolism ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Neurons ; SOX9 Transcription Factor/genetics ; Transcription Factors
Czasopismo naukowe
Tytuł :
Long non-coding RNA DUXAP9 promotes hepatocellular carcinoma cell stemness via directly interacting with sox9.
Autorzy :
Zeng R; Department of Medical Oncology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
Wang C; Department of Medical Oncology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
Wang W; Department of Medical Oncology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
Wang S; Department of Hepato-Biliary-Pancreatic and Vascular Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, P.R. China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Sep; Vol. 36 (9), pp. 1793-1801. Date of Electronic Publication: 2021 Jun 04.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*/genetics
Liver Neoplasms*/genetics
MicroRNAs*
Neoplastic Stem Cells*
RNA, Long Noncoding*/genetics
SOX9 Transcription Factor*/genetics
Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans
Czasopismo naukowe
Tytuł :
Interplay between SOX9 transcription factor and microRNAs in cancer.
Autorzy :
Ashrafizadeh M; Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı, Tuzla, 34956, Istanbul, Turkey; Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, Istanbul 34956, Turkey.
Zarrabi A; Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, Istanbul 34956, Turkey.
Orouei S; Department of Genetics, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Zabolian A; Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Saleki H; Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Azami N; Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Bejandi AK; Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Mirzaei S; Department of Biology, Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran.
Janaghard MN; Nursing and Midwifery Department, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran.
Hushmandi K; Department of Food Hygiene and Quality Control, Division of Epidemiology & Zoonoses, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Nabavi N; Department of Urological Sciences and Vancouver Prostate Centre, University of British Columbia, Vancouver, BC V6H3Z6, Canada.
Baradaran B; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Kumar AP; Cancer Science Institute of Singapore and Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Makvandi P; Centre for Materials Interfaces, Istituto Italiano di Tecnologia, viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa, Italy.
Samarghandian S; Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran. Electronic address: .
Khan H; Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan. Electronic address: .
Hamblin MR; Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jul 31; Vol. 183, pp. 681-694. Date of Electronic Publication: 2021 May 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
MicroRNAs/*metabolism
Neoplasms/*metabolism
SOX9 Transcription Factor/*metabolism
Animals ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; Neoplasms/genetics ; Neoplasms/pathology ; RNA, Circular/genetics ; RNA, Circular/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; SOX9 Transcription Factor/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
SOX9 promotes epidermal growth factor receptor-tyrosine kinase inhibitor resistance via targeting β-catenin and epithelial to mesenchymal transition in lung cancer.
Autorzy :
Tripathi SK; Cancer Drug Resistance Laboratory, Department of Life Science, National Institute of Technology Rourkela, Odisha 769008, India.
Biswal BK; Cancer Drug Resistance Laboratory, Department of Life Science, National Institute of Technology Rourkela, Odisha 769008, India. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jul 15; Vol. 277, pp. 119608. Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article
MeSH Terms :
Lung Neoplasms/*metabolism
SOX9 Transcription Factor/*metabolism
beta Catenin/*metabolism
A549 Cells ; Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Epithelial-Mesenchymal Transition/genetics ; Epithelial-Mesenchymal Transition/physiology ; ErbB Receptors/metabolism ; Gefitinib/pharmacology ; Humans ; Mice ; Mice, Nude ; Protein Kinase Inhibitors/pharmacology ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/metabolism ; SOX9 Transcription Factor/genetics ; Signal Transduction/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Role of microRNA-15a-5p/Sox9/NF-κB axis in inflammatory factors and apoptosis of murine nucleus pulposus cells in intervertebral disc degeneration.
Autorzy :
Zhang S; Department of Spine Surgery, Wuxi 9th Affiliated Hospital of Soochow University, Wuxi 214000, Jiangsu, China; Department of Minimally Invasive Spine Surgery, Wuhan Pu'ai Hospital, Wuhan 430000, Hubei, China. Electronic address: .
Song S; Department of Spine Surgery, Wuxi 9th Affiliated Hospital of Soochow University, Wuxi 214000, Jiangsu, China.
Zhuang Y; Department of Spine Surgery, Wuxi 9th Affiliated Hospital of Soochow University, Wuxi 214000, Jiangsu, China.
Hu J; Department of Minimally Invasive Spine Surgery, Wuhan Pu'ai Hospital, Wuhan 430000, Hubei, China.
Cui W; Department of Minimally Invasive Spine Surgery, Wuhan Pu'ai Hospital, Wuhan 430000, Hubei, China.
Wang X; Department of Minimally Invasive Spine Surgery, Wuhan Pu'ai Hospital, Wuhan 430000, Hubei, China.
Zhao Z; Department of Minimally Invasive Spine Surgery, Wuhan Pu'ai Hospital, Wuhan 430000, Hubei, China.
Liu X; Department of Spine Surgery, Wuxi 9th Affiliated Hospital of Soochow University, Wuxi 214000, Jiangsu, China.
Sun Z; Department of Spine Surgery, Wuxi 9th Affiliated Hospital of Soochow University, Wuxi 214000, Jiangsu, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jul 15; Vol. 277, pp. 119408. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Intervertebral Disc Degeneration/*pathology
MicroRNAs/*genetics
NF-kappa B/*metabolism
Nucleus Pulposus/*pathology
SOX9 Transcription Factor/*metabolism
Adult ; Animals ; Case-Control Studies ; Disease Models, Animal ; Female ; Humans ; Inflammation Mediators/metabolism ; Intervertebral Disc Degeneration/genetics ; Intervertebral Disc Degeneration/immunology ; Intervertebral Disc Degeneration/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; NF-kappa B/genetics ; Nucleus Pulposus/immunology ; Nucleus Pulposus/metabolism ; SOX9 Transcription Factor/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
Sox9-expressing cells promote regeneration after radiation-induced lung injury via the PI3K/AKT pathway.
Autorzy :
Chen S; Center for Translational Medicine, Institute of Precision Medicine, Department of Medical Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Li K; Center for Translational Medicine, Institute of Precision Medicine, Department of Medical Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Zhong X; Department of Neonatology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Wang G; Center for Translational Medicine, Institute of Precision Medicine, Department of Medical Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Wang X; Center for Translational Medicine, Institute of Precision Medicine, Department of Medical Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Cheng M; Center for Translational Medicine, Institute of Precision Medicine, Department of Medical Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Chen J; Center for Translational Medicine, Institute of Precision Medicine, Department of Medical Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Chen Z; Center for Translational Medicine, Institute of Precision Medicine, Department of Medical Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Chen J; Center for Translational Medicine, Institute of Precision Medicine, Department of Medical Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Zhang C; Center for Translational Medicine, Institute of Precision Medicine, Department of Medical Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Xiong G; Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510030, China.
Xu X; Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510030, China.
Chen D; Center for Translational Medicine, Institute of Precision Medicine, Department of Medical Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. .; Oncology Department, Chinese PLA General Hospital, Beijing, 100000, China. .
Li H; Center for Translational Medicine, Institute of Precision Medicine, Department of Medical Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. .; Oncology Department, Chinese PLA General Hospital, Beijing, 100000, China. .
Peng L; Oncology Department, Chinese PLA General Hospital, Beijing, 100000, China. .
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Źródło :
Stem cell research & therapy [Stem Cell Res Ther] 2021 Jul 02; Vol. 12 (1), pp. 381. Date of Electronic Publication: 2021 Jul 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lung Injury*/genetics
Lung Injury*/therapy
Radiation Injuries*/genetics
Radiation Injuries*/therapy
SOX9 Transcription Factor*/genetics
Animals ; Cell Differentiation ; Cell Proliferation ; Lung ; Mice ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Signal Transduction ; Suppressor Factors, Immunologic
Czasopismo naukowe
Tytuł :
A functional genetic screen identifies aurora kinase b as an essential regulator of Sox9-positive mouse embryonic lung progenitor cells.
Autorzy :
Ah-Cann C; Personalised Oncology Divison, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Epigenetics and Development Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Wimmer VC; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.; Advanced Technology and Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.
Weeden CE; Personalised Oncology Divison, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Marceaux C; Personalised Oncology Divison, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Law CW; Epigenetics and Development Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.; School of Mathematics and Statistics, The University of Melbourne, Parkville 3010, Australia.
Galvis L; Personalised Oncology Divison, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Filby CE; Personalised Oncology Divison, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.
Liu J; Epigenetics and Development Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.
Breslin K; Epigenetics and Development Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.
Willson T; Epigenetics and Development Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Ritchie ME; Epigenetics and Development Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.; School of Mathematics and Statistics, The University of Melbourne, Parkville 3010, Australia.
Blewitt ME; Epigenetics and Development Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Asselin-Labat ML; Personalised Oncology Divison, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
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Źródło :
Development (Cambridge, England) [Development] 2021 Jul 01; Vol. 148 (13). Date of Electronic Publication: 2021 Jul 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aurora Kinase B/*genetics
Aurora Kinase B/*metabolism
Embryonic Stem Cells/*metabolism
Endoderm/*metabolism
Lung/*embryology
SOX9 Transcription Factor/*metabolism
Animals ; Gene Expression Regulation, Developmental ; Mice ; Mice, Knockout ; Organogenesis ; SOX9 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
The conserved sex regulator DMRT1 recruits SOX9 in sexual cell fate reprogramming.
Autorzy :
Lindeman RE; Developmental Biology Center and Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455 USA.
Murphy MW; Developmental Biology Center and Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455 USA.
Agrimson KS; Developmental Biology Center and Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455 USA.
Gewiss RL; Developmental Biology Center and Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455 USA.
Bardwell VJ; Developmental Biology Center and Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455 USA.; University of Minnesota Masonic Cancer Center, Minneapolis, MN 55455, USA.
Gearhart MD; Developmental Biology Center and Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455 USA.
Zarkower D; Developmental Biology Center and Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455 USA.; University of Minnesota Masonic Cancer Center, Minneapolis, MN 55455, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jun 21; Vol. 49 (11), pp. 6144-6164.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Reprogramming/*genetics
Granulosa Cells/*metabolism
SOX9 Transcription Factor/*metabolism
Sertoli Cells/*metabolism
Transcription Factors/*metabolism
Animals ; Cells, Cultured ; Chromatin/metabolism ; DNA/metabolism ; Female ; Male ; Mice ; Regulatory Elements, Transcriptional ; SOX9 Transcription Factor/genetics ; SOXE Transcription Factors/genetics ; SOXE Transcription Factors/metabolism ; Transcriptome
Czasopismo naukowe
Tytuł :
Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors.
Autorzy :
Zhao J; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Patel J; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.; Centre for Ageing Research Program, Queensland University of Technology, Woolloongabba, QLD, Australia.
Kaur S; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Sim SL; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Wong HY; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Styke C; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Hogan I; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Kahler S; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Hamilton H; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Wadlow R; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Dight J; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Hashemi G; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Sormani L; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Roy E; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Yoder MC; Indiana Center for Regenerative Medicine and Engineering, Indianapolis, IN, USA.
Francois M; The David Richmond Laboratory for Cardiovascular Development: Gene Regulation and Editing Program, The Centenary Institute, Camperdown, NSW, Australia.; The School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Camperdown, NSW, Australia.
Khosrotehrani K; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia. .
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Źródło :
Nature communications [Nat Commun] 2021 May 07; Vol. 12 (1), pp. 2564. Date of Electronic Publication: 2021 May 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelial Cells/*metabolism
Endothelium/*metabolism
Immunoglobulin J Recombination Signal Sequence-Binding Protein/*metabolism
SOX9 Transcription Factor/*metabolism
Signal Transduction/*genetics
Animals ; Cell Differentiation/genetics ; Cell Lineage ; Endothelium/cytology ; Female ; Gene Knockout Techniques ; Hedgehog Proteins/metabolism ; Humans ; Immunoglobulin J Recombination Signal Sequence-Binding Protein/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; RNA, Small Interfering ; Receptors, Notch/metabolism ; SOX9 Transcription Factor/genetics ; Transforming Growth Factor beta/metabolism ; Wound Healing/genetics
Czasopismo naukowe
Tytuł :
Dexamethasone Induces Changes in Osteogenic Differentiation of Human Mesenchymal Stromal Cells via SOX9 and PPARG , but Not RUNX2 .
Autorzy :
Della Bella E; AO Research Institute Davos, 7270 Davos Platz, Switzerland.
Buetti-Dinh A; Laboratory of applied microbiology (LMA), Department of Environment, Constructions and Design (DACD), University of Applied Sciences of Southern Switzerland (SUPSI), 6500 Bellinzona, Switzerland.; Swiss Institute of Bioinformatics, Quartier Sorge-Batiment Genopode, 1015 Lausanne, Switzerland.
Licandro G; Dalle Molle Institute for Artificial Intelligence (IDSIA), University of Italian Switzerland (USI), 6928 Manno, Switzerland.; University of Applied Science and Art of Southern Switzerland (SUPSI), 6928 Manno, Switzerland.
Ahmad P; AO Research Institute Davos, 7270 Davos Platz, Switzerland.
Basoli V; AO Research Institute Davos, 7270 Davos Platz, Switzerland.
Alini M; AO Research Institute Davos, 7270 Davos Platz, Switzerland.
Stoddart MJ; AO Research Institute Davos, 7270 Davos Platz, Switzerland.; Department of Orthopedics and Trauma Surgery, Medical Center-Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, 79106 Freiburg, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 30; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 30.
Typ publikacji :
Journal Article
MeSH Terms :
Dexamethasone/*pharmacology
Glucocorticoids/*pharmacology
Mesenchymal Stem Cells/*drug effects
Osteogenesis/*drug effects
PPAR gamma/*metabolism
SOX9 Transcription Factor/*metabolism
Adult ; Cell Differentiation/drug effects ; Cells, Cultured ; Core Binding Factor Alpha 1 Subunit/genetics ; Core Binding Factor Alpha 1 Subunit/metabolism ; Female ; Gene Expression Regulation/drug effects ; Humans ; Male ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; PPAR gamma/genetics ; SOX9 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
Deacetylation of FOXO4 by Sirt1 stabilizes chondrocyte extracellular matrix upon activating SOX9.
Autorzy :
Ma ZX; Department of Orthopedics, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. .
Xu H
Xiang W
Qi J
Xu YY
Zhao ZG
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Źródło :
European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2021 Jan; Vol. 25 (2), pp. 626-635.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Cycle Proteins/*metabolism
Chondrocytes/*metabolism
Extracellular Matrix/*metabolism
Forkhead Transcription Factors/*metabolism
SOX9 Transcription Factor/*metabolism
Sirtuin 1/*metabolism
Acetylation ; Adult ; Cell Cycle Proteins/genetics ; Cells, Cultured ; Forkhead Transcription Factors/genetics ; Humans ; Interleukin-1beta/metabolism ; Middle Aged ; SOX9 Transcription Factor/analysis ; SOX9 Transcription Factor/genetics ; Sirtuin 1/analysis ; Sirtuin 1/genetics
Czasopismo naukowe
Tytuł :
Up-regulation of sex-determining region Y-box 9 (SOX9) in growth hormone-secreting pituitary adenomas.
Autorzy :
Shirian FI; Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Ghorbani M; Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran. .
Khamseh ME; Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Imani M; Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Panahi M; Firozgar Hospital, Pathology Department, Iran University of Medical Sciences, Tehran, Iran.
Alimohammadi A; Iranian Legal Medicine Organizations, Tehran, Iran.
Nourbakhsh M; Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Salimi V; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Tavakoli-Yaraki M; Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. .
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Źródło :
BMC endocrine disorders [BMC Endocr Disord] 2021 Mar 18; Vol. 21 (1), pp. 50. Date of Electronic Publication: 2021 Mar 18.
Typ publikacji :
Journal Article
MeSH Terms :
Adenoma/*genetics
Growth Hormone-Secreting Pituitary Adenoma/*genetics
SOX9 Transcription Factor/*genetics
Acromegaly/genetics ; Acromegaly/metabolism ; Acromegaly/pathology ; Adenoma/metabolism ; Adenoma/pathology ; Adult ; Aged ; Case-Control Studies ; Female ; Gene Expression Regulation, Neoplastic ; Growth Hormone-Secreting Pituitary Adenoma/metabolism ; Growth Hormone-Secreting Pituitary Adenoma/pathology ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; SOX9 Transcription Factor/metabolism ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2.
Autorzy :
Ono K; Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan.; Department of Orthopedics, Nippon Medical School, Tokyo, Japan.
Hata K; Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan. .
Nakamura E; Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan.
Ishihara S; Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan.
Kobayashi S; Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan.
Nakanishi M; Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan.; Department of Pathology, Wakayama Medical University, Wakayama, Japan.
Yoshida M; Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan.
Takahata Y; Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan.
Murakami T; Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan.
Takenoshita S; Advanced Clinical Research Center, Fukushima Medical University, Fukushima, Japan.
Komori T; Department of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Nishimura R; Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan. .
Yoneda T; Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan.
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Źródło :
Communications biology [Commun Biol] 2021 Mar 11; Vol. 4 (1), pp. 326. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Osteogenesis*
Bone and Bones/*metabolism
Chondrocytes/*metabolism
Core Binding Factor Alpha 1 Subunit/*metabolism
DNA-Binding Proteins/*metabolism
Dwarfism/*metabolism
SOX9 Transcription Factor/*metabolism
Transcription Factors/*metabolism
Animals ; Bone and Bones/pathology ; Bone and Bones/physiopathology ; Cell Line, Tumor ; Chondrocytes/pathology ; Chondrogenesis ; Core Binding Factor Alpha 1 Subunit/genetics ; DNA-Binding Proteins/genetics ; Disease Models, Animal ; Dwarfism/genetics ; Dwarfism/pathology ; Dwarfism/physiopathology ; Epigenesis, Genetic ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Hypertrophy ; Mice, Inbred C57BL ; Mice, Knockout ; SOX9 Transcription Factor/genetics ; Signal Transduction ; Transcription Factors/genetics ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Sox9/INHBB axis-mediated crosstalk between the hepatoma and hepatic stellate cells promotes the metastasis of hepatocellular carcinoma.
Autorzy :
Chen Y; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing, 210093, PR China.
Qian B; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing, 210093, PR China.
Sun X; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing, 210093, PR China.
Kang Z; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing, 210093, PR China.
Huang Z; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing, 210093, PR China.
Ding Z; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing, 210093, PR China.
Dong L; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing, 210093, PR China.
Chen J; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing, 210093, PR China; State Key Laboratory of Analytical Chemistry for Life Sciences and Collaborative Innovation Center of Chemistry for Life Sciences, Nanjing, 210093, PR China.
Zhang J; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing, 210093, PR China. Electronic address: .
Zang Y; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing, 210093, PR China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2021 Feb 28; Vol. 499, pp. 243-254. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Hepatocellular/*genetics
Hepatic Stellate Cells/*pathology
Inhibin-beta Subunits/*genetics
Liver Cirrhosis/*genetics
Liver Neoplasms/*genetics
SOX9 Transcription Factor/*metabolism
Activins/metabolism ; Animals ; Carcinoma, Hepatocellular/secondary ; Cell Proliferation/genetics ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Hep G2 Cells ; Humans ; Liver/cytology ; Liver/pathology ; Liver Cirrhosis/pathology ; Liver Neoplasms/pathology ; Male ; Mice ; Paracrine Communication/genetics ; SOX9 Transcription Factor/genetics ; Signal Transduction/genetics ; Smad Proteins/metabolism ; Tumor Microenvironment/genetics ; Up-Regulation ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
TGF-β Signaling Promotes Glioma Progression Through Stabilizing Sox9.
Autorzy :
Chao M; Departments of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Liu N; Departments of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Sun Z; Departments of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Jiang Y; Departments of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Jiang T; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China.
Xv M; Departments of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Jia L; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China.
Tu Y; Departments of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Wang L; Departments of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Feb 03; Vol. 11, pp. 592080. Date of Electronic Publication: 2021 Feb 03 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Brain Neoplasms/*etiology
Brain Neoplasms/*metabolism
Glioma/*etiology
Glioma/*metabolism
SOX9 Transcription Factor/*metabolism
Transforming Growth Factor beta/*metabolism
Animals ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Disease Models, Animal ; Disease Progression ; Disease Susceptibility ; Gene Expression ; Gene Knockdown Techniques ; Glioma/pathology ; Humans ; Immunohistochemistry ; Mice ; Protein Binding ; Protein Stability ; SOX9 Transcription Factor/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
miR-145 attenuates cardiac fibrosis through the AKT/GSK-3β/β-catenin signaling pathway by directly targeting SOX9 in fibroblasts.
Autorzy :
Cui S; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.; Cardiovascular Research Institute, Wuhan University, Wuhan, China.; Hubei Key Laboratory of Cardiology, Wuhan, China.
Liu Z; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.; Cardiovascular Research Institute, Wuhan University, Wuhan, China.; Hubei Key Laboratory of Cardiology, Wuhan, China.
Tao B; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.; Cardiovascular Research Institute, Wuhan University, Wuhan, China.; Hubei Key Laboratory of Cardiology, Wuhan, China.
Fan S; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.; Cardiovascular Research Institute, Wuhan University, Wuhan, China.; Hubei Key Laboratory of Cardiology, Wuhan, China.
Pu Y; Renmin Hospital of Hannan District, Renmin Hospital of Wuhan University, Wuhan, China.
Meng X; Wuhan Fourth Hospital, Wuhan, China.
Li D; Department of Microbiology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Xia H; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.; Cardiovascular Research Institute, Wuhan University, Wuhan, China.; Hubei Key Laboratory of Cardiology, Wuhan, China.
Xu L; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.; Cardiovascular Research Institute, Wuhan University, Wuhan, China.; Hubei Key Laboratory of Cardiology, Wuhan, China.
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Źródło :
Journal of cellular biochemistry [J Cell Biochem] 2021 Feb; Vol. 122 (2), pp. 209-221. Date of Electronic Publication: 2020 Sep 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fibroblasts/*metabolism
Fibrosis/*metabolism
Glycogen Synthase Kinase 3 beta/*metabolism
MicroRNAs/*metabolism
Myocardial Infarction/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
SOX9 Transcription Factor/*metabolism
beta Catenin/*metabolism
Animals ; Fibrosis/genetics ; Flow Cytometry ; Glycogen Synthase Kinase 3 beta/genetics ; Male ; MicroRNAs/genetics ; Myocardial Infarction/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Rats ; Rats, Sprague-Dawley ; SOX9 Transcription Factor/genetics ; Signal Transduction/genetics ; Signal Transduction/physiology ; beta Catenin/genetics
Czasopismo naukowe
Tytuł :
Sex determining region Y-box 9 induced microtubule formation and epithelial⁃mesenchymal transition in human oral squamous cell carcinoma CAL27 cells.
Autorzy :
Huang S; Dept. of Stomatology, East Hospital, Mafangshan Campus, Wuhan University of Science and Technology, Wuhan 430000, China.
Zhang QY; Dept. of Cariology and Endodontics, School of Stomatology, Wuhan University, Wuhan 430000, China.
He AE; Dept. of Stomatology, The Fifth Hospital of Wuhan, Wuhan 430000, China.
Li HB; Dept. of Prosthodontics, School of Stomatology, Wuhan University, Wuhan 430000, China.
Zhang ZX; Dept. of Stomatology, Affiliated Hospital of Tongji Medical University, Wuhan 430000, China.
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Źródło :
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology [Hua Xi Kou Qiang Yi Xue Za Zhi] 2021 Feb 01; Vol. 39 (1), pp. 74-80.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Squamous Cell*
Head and Neck Neoplasms*
Mouth Neoplasms*
SOX9 Transcription Factor*/metabolism
Cell Line, Tumor ; Epithelial-Mesenchymal Transition ; Humans ; Microtubules/metabolism ; Squamous Cell Carcinoma of Head and Neck ; Wnt Signaling Pathway ; beta Catenin/metabolism
Czasopismo naukowe

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