Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Wyszukujesz frazę ""SOX9 Transcription Factor"" wg kryterium: Temat


Tytuł:
Sox9 is involved in the thyroid differentiation program and is regulated by crosstalk between TSH, TGFβ and thyroid transcription factors.
Autorzy:
López-Márquez A; Instituto de Investigaciones Biomédicas 'Alberto Sols'. Consejo Superior de Investigaciones Científicas (CSIC) y Universidad Autónoma de Madrid (UAM), CSIC-UAM., C/Arturo Duperier 4, 28029, Madrid, Spain.; Laboratorio de Investigación Aplicada en Enfermedades Neuromusculares, Unidad de Patología Neuromuscular, Servicio de Neuropediatría, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
Carrasco-López C; Instituto de Investigaciones Biomédicas 'Alberto Sols'. Consejo Superior de Investigaciones Científicas (CSIC) y Universidad Autónoma de Madrid (UAM), CSIC-UAM., C/Arturo Duperier 4, 28029, Madrid, Spain.
Martínez-Cano A; Instituto de Investigaciones Biomédicas 'Alberto Sols'. Consejo Superior de Investigaciones Científicas (CSIC) y Universidad Autónoma de Madrid (UAM), CSIC-UAM., C/Arturo Duperier 4, 28029, Madrid, Spain.; Centro de Investigaciones Biomédicas en Red del Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain.
Lemoine P; Cell Biology Unit, de Duve Institute and Université Catholique de Louvain, 1200, Brussels, Belgium.
Pierreux CE; Cell Biology Unit, de Duve Institute and Université Catholique de Louvain, 1200, Brussels, Belgium.
Santisteban P; Instituto de Investigaciones Biomédicas 'Alberto Sols'. Consejo Superior de Investigaciones Científicas (CSIC) y Universidad Autónoma de Madrid (UAM), CSIC-UAM., C/Arturo Duperier 4, 28029, Madrid, Spain. .; Centro de Investigaciones Biomédicas en Red del Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2022 Feb 09; Vol. 12 (1), pp. 2144. Date of Electronic Publication: 2022 Feb 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
SOX9 Transcription Factor/*metabolism
Thyroid Epithelial Cells/*cytology
Thyroid Epithelial Cells/*metabolism
Thyroid Gland/*metabolism
Thyrotropin/*metabolism
Transcription Factors/*metabolism
Transforming Growth Factor beta/*metabolism
Animals ; Cell Differentiation ; Cell Line ; Cyclic AMP/metabolism ; Cyclic AMP Response Element-Binding Protein/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Gene Expression Regulation ; Mice ; PAX8 Transcription Factor/genetics ; PAX8 Transcription Factor/metabolism ; Promoter Regions, Genetic ; SOX9 Transcription Factor/genetics ; Signal Transduction ; Thyroid Gland/cytology ; Thyroid Gland/embryology ; Thyroid Nuclear Factor 1/genetics ; Thyroid Nuclear Factor 1/metabolism ; Thyrotropin/pharmacology ; Transcription, Genetic ; Transforming Growth Factor beta/pharmacology
Czasopismo naukowe
Tytuł:
Switching of Sox9 expression during musculoskeletal system development.
Autorzy:
Nagakura R; Department of Anatomy, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo, 101-0061, Japan.
Yamamoto M; Department of Anatomy, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo, 101-0061, Japan.
Jeong J; Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, 345 E. 24th Street, New York, NY, 10010, USA.
Hinata N; Department of Urology, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Kobe, 650-0017, Japan.
Katori Y; Department of Otolaryngology-Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.
Chang WJ; School of Dentistry, College of Oral Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan.
Abe S; Department of Anatomy, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo, 101-0061, Japan. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2020 May 21; Vol. 10 (1), pp. 8425. Date of Electronic Publication: 2020 May 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bone Development/*physiology
Muscle Development/*physiology
SOX9 Transcription Factor/*metabolism
Stem Cells/*metabolism
Tendons/*growth & development
Animals ; Bone Development/genetics ; Bone and Bones/metabolism ; Mice ; Mice, Transgenic ; Muscle Development/genetics ; Muscles/metabolism ; SOX9 Transcription Factor/genetics ; Tendons/metabolism
Czasopismo naukowe
Tytuł:
MicroRNA-520f-3p inhibits proliferation of gastric cancer cells via targeting SOX9 and thereby inactivating Wnt signaling.
Autorzy:
Chen JQ; Department of Gastroenterology, Shidong Hospital, Yangpu District, Shanghai, Anhui Medical University, 999 Shiguang Road, Shanghai, 200438, China.
Huang ZP; Department of Hepatobiliary Surgery, General Hospital of Southern Theatre Command, 111 Liuhua Road, Guangzhou, 510010, China.; Department of Interventional, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai Road, Shanghai, 200438, China.
Li HF; Department of Interventional, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai Road, Shanghai, 200438, China.
Ou YL; Department of General Surgery, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, China.
Huo F; Department of Hepatobiliary Surgery, General Hospital of Southern Theatre Command, 111 Liuhua Road, Guangzhou, 510010, China. .
Hu LK; Department of Gastroenterology, Shidong Hospital, Yangpu District, Shanghai, Anhui Medical University, 999 Shiguang Road, Shanghai, 200438, China. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2020 Apr 10; Vol. 10 (1), pp. 6197. Date of Electronic Publication: 2020 Apr 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Wnt Signaling Pathway*
MicroRNAs/*genetics
SOX9 Transcription Factor/*genetics
Stomach Neoplasms/*genetics
Cell Line, Tumor ; Cell Proliferation ; Female ; Humans ; Male ; Middle Aged ; SOX9 Transcription Factor/metabolism ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology
Czasopismo naukowe
Tytuł:
SOX9 promotes tumor progression through the axis BMI1-p21 .
Autorzy:
Aldaz P; Cellular Oncology Group, Biodonostia Health Research Institute, San Sebastian, Spain.
Otaegi-Ugartemendia M; Cellular Oncology Group, Biodonostia Health Research Institute, San Sebastian, Spain.
Saenz-Antoñanzas A; Cellular Oncology Group, Biodonostia Health Research Institute, San Sebastian, Spain.
Garcia-Puga M; Cellular Oncology Group, Biodonostia Health Research Institute, San Sebastian, Spain.
Moreno-Valladares M; Cellular Oncology Group, Biodonostia Health Research Institute, San Sebastian, Spain.; Donostia Hospital, San Sebastian, Spain.
Flores JM; Department of Animal Medicine and Surgery, Complutense University of Madrid, Madrid, Spain.
Gerovska D; Computational Biology and Systems Biomedicine Group, Biodonostia Health Research Institute, San Sebastian, Spain.
Arauzo-Bravo MJ; Computational Biology and Systems Biomedicine Group, Biodonostia Health Research Institute, San Sebastian, Spain.; CIBERfes, Madrid, Spain.; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
Samprón N; Cellular Oncology Group, Biodonostia Health Research Institute, San Sebastian, Spain.; Donostia Hospital, San Sebastian, Spain.; CIBERfes, Madrid, Spain.
Matheu A; Cellular Oncology Group, Biodonostia Health Research Institute, San Sebastian, Spain. .; CIBERfes, Madrid, Spain. .; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain. .
Carrasco-Garcia E; Cellular Oncology Group, Biodonostia Health Research Institute, San Sebastian, Spain. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2020 Jan 15; Vol. 10 (1), pp. 357. Date of Electronic Publication: 2020 Jan 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cyclin-Dependent Kinase Inhibitor p21/*metabolism
Neoplasms/*genetics
Polycomb Repressive Complex 1/*metabolism
SOX9 Transcription Factor/*metabolism
Adenocarcinoma ; Cell Line, Tumor ; Cell Proliferation ; Cell Survival ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Glioblastoma ; Humans ; Neoplasms/metabolism ; Neoplastic Processes ; Pancreatic Neoplasms ; SOX9 Transcription Factor/genetics ; Stomach Neoplasms
Czasopismo naukowe
Tytuł:
sox9b is required in cardiomyocytes for cardiac morphogenesis and function.
Autorzy:
Gawdzik JC; Molecular and Environmental Toxicology Center, University of Wisconsin at Madison, Madison, WI, USA.; Division of Pharmaceutical Sciences, University of Wisconsin at Madison, Madison, WI, USA.
Yue MS; Molecular and Environmental Toxicology Center, University of Wisconsin at Madison, Madison, WI, USA.; Division of Pharmaceutical Sciences, University of Wisconsin at Madison, Madison, WI, USA.
Martin NR; Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Elemans LMH; Division of Pharmaceutical Sciences, University of Wisconsin at Madison, Madison, WI, USA.; Division of Toxicology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands.
Lanham KA; Division of Pharmaceutical Sciences, University of Wisconsin at Madison, Madison, WI, USA.
Heideman W; Molecular and Environmental Toxicology Center, University of Wisconsin at Madison, Madison, WI, USA.; Division of Pharmaceutical Sciences, University of Wisconsin at Madison, Madison, WI, USA.
Rezendes R; Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Baker TR; Wayne State University, Institute of Environmental Health Sciences, Detroit, MI, USA.
Taylor MR; Division of Pharmaceutical Sciences, University of Wisconsin at Madison, Madison, WI, USA.
Plavicki JS; Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA. jessica_.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2018 Sep 17; Vol. 8 (1), pp. 13906. Date of Electronic Publication: 2018 Sep 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Morphogenesis*
Heart/*embryology
Myocytes, Cardiac/*metabolism
SOX9 Transcription Factor/*genetics
Animals ; Gene Expression Regulation, Developmental ; Genes, Dominant ; HEK293 Cells ; Humans ; Mice ; SOX9 Transcription Factor/metabolism ; Transcription, Genetic ; Zebrafish
Czasopismo naukowe
Tytuł:
Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development.
Autorzy:
Tsuji-Hosokawa A; Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8510, Japan.
Kashimada K; Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8510, Japan. .
Kato T; Department of Systems BioMedicine, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo, 157-8535, Japan.
Ogawa Y; Department of Systems BioMedicine, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo, 157-8535, Japan.
Nomura R; Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8510, Japan.
Takasawa K; Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8510, Japan.
Lavery R; Center for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.
Coschiera A; IRP Laboratory of Genetics, NIH Biomedical Research Center National Institute on Aging, Baltimore, 21224 MD, USA.
Schlessinger D; IRP Laboratory of Genetics, NIH Biomedical Research Center National Institute on Aging, Baltimore, 21224 MD, USA.
Harley VR; Center for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.
Takada S; Department of Systems BioMedicine, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo, 157-8535, Japan.
Morio T; Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8510, Japan.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2018 Sep 05; Vol. 8 (1), pp. 13263. Date of Electronic Publication: 2018 Sep 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein-Arginine Deiminases/*biosynthesis
SOX9 Transcription Factor/*metabolism
Sertoli Cells/*metabolism
Testis/*embryology
Animals ; Cell Line ; Forkhead Box Protein L2/metabolism ; Gene Expression Regulation, Developmental ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Protein-Arginine Deiminase Type 2 ; Protein-Arginine Deiminases/genetics ; Protein-Arginine Deiminases/metabolism ; SOX9 Transcription Factor/genetics ; Sertoli Cells/cytology ; Testis/metabolism
Czasopismo naukowe
Tytuł:
Neutrophils are important for the development of pro-reparative macrophages after irreversible electroporation of the liver in mice.
Autorzy:
Lopez-Ichikawa M; Department of Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA, 94143, USA.
Vu NK; Department of Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA, 94143, USA.
Nijagal A; Department of Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA, 94143, USA.
Rubinsky B; Department of Mechanical Engineering, University of California, Berkeley, 6124 Etcheverry Hall, Berkeley, CA, 94720, USA.
Chang TT; Department of Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA, 94143, USA. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2021 Jul 22; Vol. 11 (1), pp. 14986. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Liver Regeneration*
Liver/*diagnostic imaging
Macrophages/*metabolism
Neutrophils/*metabolism
Animals ; Antigens, Ly ; Electroporation ; Female ; Intravital Microscopy ; Liver/immunology ; Male ; Mice ; Regenerative Medicine ; SOX9 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł:
A controlled double-duration inducible gene expression system for cartilage tissue engineering.
Autorzy:
Ma Y; MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, China.; School of Life Sciences, Tsinghua University, Beijing, China.; Center for Synthetic &System Biology, Tsinghua University, Beijing, China.
Li J; MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, China.; School of Life Sciences, Tsinghua University, Beijing, China.; Center for Synthetic &System Biology, Tsinghua University, Beijing, China.
Yao Y; MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, China.; School of Life Sciences, Tsinghua University, Beijing, China.; Center for Synthetic &System Biology, Tsinghua University, Beijing, China.
Wei D; MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, China.; School of Life Sciences, Tsinghua University, Beijing, China.; Center for Synthetic &System Biology, Tsinghua University, Beijing, China.
Wang R; MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, China.; School of Life Sciences, Tsinghua University, Beijing, China.; Center for Synthetic &System Biology, Tsinghua University, Beijing, China.
Wu Q; MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, China.; School of Life Sciences, Tsinghua University, Beijing, China.; Center for Synthetic &System Biology, Tsinghua University, Beijing, China.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2016 May 25; Vol. 6, pp. 26617. Date of Electronic Publication: 2016 May 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chondrogenesis*
Gene Expression*
Proto-Oncogene Proteins c-bcl-2*/biosynthesis
Proto-Oncogene Proteins c-bcl-2*/genetics
SOX9 Transcription Factor*/biosynthesis
SOX9 Transcription Factor*/genetics
Cartilage/*metabolism
Mesenchymal Stem Cells/*metabolism
Tissue Engineering/*methods
Animals ; Cartilage/cytology ; Cell Line ; Cell Survival/genetics ; Mesenchymal Stem Cells/cytology ; Mice
Czasopismo naukowe
Tytuł:
Transformation of SOX9 cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma.
Autorzy:
Chen J; Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, 90033, USA.
Debebe A; Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, 90033, USA.
Zeng N; Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, 90033, USA.
Kopp J; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
He L; Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, 90033, USA.
Sander M; Department of Pediatrics and Cellar and Molecular Medicine, UCSD, La Jolla, CA, 92093, USA.
Stiles BL; Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, 90033, USA. .; Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2021 Jun 03; Vol. 11 (1), pp. 11823. Date of Electronic Publication: 2021 Jun 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Gene Deletion*
Carcinogenesis/*pathology
Carcinoma, Hepatocellular/*complications
Cell Transformation, Neoplastic/*pathology
Cholangiocarcinoma/*pathology
Liver Neoplasms/*complications
PTEN Phosphohydrolase/*genetics
SOX9 Transcription Factor/*metabolism
Animals ; Biomarkers, Tumor/metabolism ; Cell Proliferation ; Diet, High-Fat ; Down-Regulation/genetics ; Fatty Liver ; Liver/injuries ; Liver/pathology ; Mice ; Models, Biological ; Neoplastic Stem Cells/pathology ; PTEN Phosphohydrolase/metabolism ; Phenotype
Czasopismo naukowe
Tytuł:
TGF-β regulates phosphorylation and stabilization of Sox9 protein in chondrocytes through p38 and Smad dependent mechanisms.
Autorzy:
Coricor G; University of Alabama at Birmingham, Department of Cell, Developmental, and Integrative Biology, Birmingham, Alabama, 35294-0005, USA.
Serra R; University of Alabama at Birmingham, Department of Cell, Developmental, and Integrative Biology, Birmingham, Alabama, 35294-0005, USA.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2016 Dec 08; Vol. 6, pp. 38616. Date of Electronic Publication: 2016 Dec 08.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Chondrocytes/*metabolism
SOX9 Transcription Factor/*metabolism
Smad3 Protein/*metabolism
Transforming Growth Factor beta/*metabolism
p38 Mitogen-Activated Protein Kinases/*metabolism
Cell Line ; Gene Expression Regulation ; Humans ; Phosphorylation ; Protein Stability ; SOX9 Transcription Factor/genetics ; Smad2 Protein/metabolism ; Smad3 Protein/genetics ; p38 Mitogen-Activated Protein Kinases/genetics
Czasopismo naukowe
Tytuł:
The conditional deletion of steroidogenic factor 1 (Nr5a1) in Sox9-Cre mice compromises testis differentiation.
Autorzy:
Ikeda Y; Department of Anatomy, Aichi Gakuin University School of Dentistry, 1-100 Kusumoto-Cho, Chikusa-ku, Nagoya, Aichi, 464-8650, Japan. .
Tagami A; Department of Anatomy, Aichi Gakuin University School of Dentistry, 1-100 Kusumoto-Cho, Chikusa-ku, Nagoya, Aichi, 464-8650, Japan.
Maekawa M; Department of Anatomy, Aichi Gakuin University School of Dentistry, 1-100 Kusumoto-Cho, Chikusa-ku, Nagoya, Aichi, 464-8650, Japan.
Nagai A; Department of Anatomy, Aichi Gakuin University School of Dentistry, 1-100 Kusumoto-Cho, Chikusa-ku, Nagoya, Aichi, 464-8650, Japan.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2021 Feb 24; Vol. 11 (1), pp. 4486. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Differentiation/*physiology
Integrases/*metabolism
SOX9 Transcription Factor/*metabolism
Steroidogenic Factor 1/*metabolism
Testis/*metabolism
Animals ; Female ; Gene Expression Regulation, Developmental/physiology ; Gonads/metabolism ; Gonads/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Ovary/metabolism ; Ovary/physiology ; Sertoli Cells/metabolism ; Sertoli Cells/physiology ; Sex Differentiation/physiology
Czasopismo naukowe
Tytuł:
Obesity alters the collagen organization and mechanical properties of murine cartilage.
Autorzy:
Collins AT; Department of Orthopaedic Surgery, Duke University School of Medicine, DUMC Box 3093, Durham, NC, 27710, USA.
Hu G; Department of Orthopaedic Surgery, Duke University School of Medicine, DUMC Box 3093, Durham, NC, 27710, USA.
Newman H; Department of Orthopaedic Surgery, Duke University School of Medicine, DUMC Box 3093, Durham, NC, 27710, USA.
Reinsvold MH; Department of Orthopaedic Surgery, Duke University School of Medicine, DUMC Box 3093, Durham, NC, 27710, USA.
Goldsmith MR; Department of Orthopaedic Surgery, Duke University School of Medicine, DUMC Box 3093, Durham, NC, 27710, USA.
Twomey-Kozak JN; Department of Orthopaedic Surgery, Duke University School of Medicine, DUMC Box 3093, Durham, NC, 27710, USA.
Leddy HA; Shared Materials Instrumentation Facility, Pratt School of Engineering, Duke University, Durham, NC, 27710, USA.
Sharma D; Department of Orthopaedic Surgery, Duke University School of Medicine, DUMC Box 3093, Durham, NC, 27710, USA.
Shen L; Department of Orthopaedic Surgery, Duke University School of Medicine, DUMC Box 3093, Durham, NC, 27710, USA.
DeFrate LE; Department of Orthopaedic Surgery, Duke University School of Medicine, DUMC Box 3093, Durham, NC, 27710, USA. .; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, 27710, USA. .; Department of Mechanical Engineering and Materials Science, Pratt School of Engineering, Duke University, Durham, NC, 27710, USA. .
Karner CM; Department of Orthopaedic Surgery, Duke University School of Medicine, DUMC Box 3093, Durham, NC, 27710, USA.; Department of Cell Biology, Duke University School of Medicine, Durham, NC, 27710, USA.; Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2021 Jan 15; Vol. 11 (1), pp. 1626. Date of Electronic Publication: 2021 Jan 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Elastic Modulus*
Cartilage, Articular/*metabolism
Collagen/*metabolism
Obesity/*pathology
Animals ; Cartilage, Articular/pathology ; Diet, High-Fat ; Disease Models, Animal ; Glucose Tolerance Test ; Liver/metabolism ; Liver/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Microscopy, Atomic Force ; Obesity/complications ; Obesity/metabolism ; Osteoarthritis/etiology ; Osteoarthritis/metabolism ; Osteoarthritis/pathology ; SOX9 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł:
Intermittent hypoxia inhibits mandibular cartilage growth with reduced TGF-β and SOX9 expressions in neonatal rats.
Autorzy:
Lekvijittada K; Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.; Department of Orthodontics, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.; Department of Forensic Medicine, Graduate School of Medicine, Tokyo Medical University, Tokyo, Japan.
Hosomichi J; Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan. .; Department of Forensic Medicine, Graduate School of Medicine, Tokyo Medical University, Tokyo, Japan. .
Maeda H; Department of Forensic Medicine, Graduate School of Medicine, Tokyo Medical University, Tokyo, Japan.
Hong H; Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.; Department of Forensic Medicine, Graduate School of Medicine, Tokyo Medical University, Tokyo, Japan.
Changsiripun C; Department of Orthodontics, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Kuma YI; Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
Oishi S; Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
Suzuki JI; Department of Advanced Clinical Science and Therapeutics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yoshida KI; Department of Forensic Medicine, Graduate School of Medicine, Tokyo Medical University, Tokyo, Japan.
Ono T; Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2021 Jan 13; Vol. 11 (1), pp. 1140. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cartilage/*growth & development
Hypoxia/*complications
Mandible/*growth & development
SOX9 Transcription Factor/*genetics
Transforming Growth Factor beta/*genetics
Animals ; Animals, Newborn ; Cartilage/metabolism ; Chondrogenesis ; Down-Regulation ; Gene Expression Regulation, Developmental ; Hypoxia/genetics ; Male ; Mandible/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł:
Impact of Sox9 dosage and Hes1-mediated Notch signaling in controlling the plasticity of adult pancreatic duct cells in mice.
Autorzy:
Hosokawa S; 1] Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan [2] Department of Clinical Application, Center for iPS cell Research and Application, Kyoto University, Kyoto, Japan.
Furuyama K; 1] Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan [2] Department of Clinical Application, Center for iPS cell Research and Application, Kyoto University, Kyoto, Japan.
Horiguchi M; 1] Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan [2] Department of Clinical Application, Center for iPS cell Research and Application, Kyoto University, Kyoto, Japan.
Aoyama Y; 1] Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan [2] Department of Clinical Application, Center for iPS cell Research and Application, Kyoto University, Kyoto, Japan.
Tsuboi K; 1] Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan [2] Department of Clinical Application, Center for iPS cell Research and Application, Kyoto University, Kyoto, Japan.
Sakikubo M; 1] Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan [2] Department of Clinical Application, Center for iPS cell Research and Application, Kyoto University, Kyoto, Japan.
Goto T; 1] Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan [2] Department of Clinical Application, Center for iPS cell Research and Application, Kyoto University, Kyoto, Japan.
Hirata K; 1] Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan [2] Department of Clinical Application, Center for iPS cell Research and Application, Kyoto University, Kyoto, Japan.
Tanabe W; 1] Department of Clinical Application, Center for iPS cell Research and Application, Kyoto University, Kyoto, Japan [2] Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Nakano Y; Department of Clinical Application, Center for iPS cell Research and Application, Kyoto University, Kyoto, Japan.
Akiyama H; Department of Orthopaedics, Gifu University, Gifu, Japan.
Kageyama R; Institute for Virus Research, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Uemoto S; Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kawaguchi Y; Department of Clinical Application, Center for iPS cell Research and Application, Kyoto University, Kyoto, Japan.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2015 Feb 17; Vol. 5, pp. 8518. Date of Electronic Publication: 2015 Feb 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Plasticity*
Gene Dosage*
Signal Transduction*
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Homeodomain Proteins/*metabolism
Pancreatic Ducts/*cytology
Pancreatic Ducts/*metabolism
Receptors, Notch/*metabolism
SOX9 Transcription Factor/*genetics
Age Factors ; Animals ; Cell Differentiation/genetics ; Gene Expression ; Mice ; Mice, Transgenic ; Models, Biological ; SOX9 Transcription Factor/metabolism ; Transcription Factor HES-1 ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
Atelocollagen promotes chondrogenic differentiation of human adipose-derived mesenchymal stem cells.
Autorzy:
Kim SA; Department of Orthopedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Sur YJ; Department of Orthopedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Cho ML; The Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Go EJ; Department of Orthopedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Kim YH; Department of Orthopedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Shetty AA; The Institute of Medical Sciences, Faculty of Health and Wellbeing, Canterbury Christ Church University, Kent, UK.
Kim SJ; Department of Orthopedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2020 Jun 30; Vol. 10 (1), pp. 10678. Date of Electronic Publication: 2020 Jun 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Differentiation/*drug effects
Chondrogenesis/*drug effects
Collagen/*pharmacology
Mesenchymal Stem Cells/*drug effects
Aged ; Aggrecans/metabolism ; Cartilage/metabolism ; Cells, Cultured ; Chondrocytes/drug effects ; Chondrocytes/metabolism ; Core Binding Factor Alpha 1 Subunit/metabolism ; Fibrillar Collagens/metabolism ; Humans ; Matrilin Proteins/metabolism ; SOX9 Transcription Factor/metabolism ; Tissue Engineering/methods
Czasopismo naukowe
Tytuł:
Doublecortin-like kinase 1 promotes hepatocyte clonogenicity and oncogenic programming via non-canonical β-catenin-dependent mechanism.
Autorzy:
Ali N; Department of Medicine, Section of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. .; Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK73104, USA. .; Department of Veterans Affairs Medical Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. .
Nguyen CB; Department of Medicine, Section of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Chandrakesan P; Department of Medicine, Section of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.; Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK73104, USA.; Department of Veterans Affairs Medical Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Wolf RF; Department of Veterans Affairs Medical Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Qu D; Department of Medicine, Section of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.; Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK73104, USA.
May R; Department of Medicine, Section of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Goretsky T; Division of Gastroenterology, Department of Internal Medicine, University of Kentucky, Lexington, KY, 40536, USA.
Fazili J; Department of Medicine, Section of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.; Department of Veterans Affairs Medical Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Barrett TA; Division of Gastroenterology, Department of Internal Medicine, University of Kentucky, Lexington, KY, 40536, USA.
Li M; Department of Medicine, Section of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.; Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK73104, USA.
Huycke MM; Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK73104, USA.; Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Bronze MS; Department of Medicine, Section of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Houchen CW; Department of Medicine, Section of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. .; Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK73104, USA. .; Department of Veterans Affairs Medical Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2020 Jun 29; Vol. 10 (1), pp. 10578. Date of Electronic Publication: 2020 Jun 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Hepatocytes/*cytology
Hepatocytes/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Protein Serine-Threonine Kinases/*metabolism
beta Catenin/*metabolism
Animals ; Carcinogenesis ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Doublecortin-Like Kinases ; Glycogen Synthase Kinase 3 beta/metabolism ; Hep G2 Cells ; Hepatocytes/enzymology ; Hepatocytes/pathology ; Heterografts ; Humans ; Liver Cirrhosis/pathology ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Mice ; Mice, Inbred C57BL ; Neoplastic Stem Cells/metabolism ; SOX9 Transcription Factor/metabolism ; Spheroids, Cellular ; alpha-Fetoproteins/metabolism
Czasopismo naukowe
Tytuł:
Biochemical characteristics of the chondrocyte-enriched SNORC protein and its transcriptional regulation by SOX9.
Autorzy:
Jaiswal PK; Shriners Hospitals for Children - Canada, Montreal, Quebec, Canada.
Aljebali L; Shriners Hospitals for Children - Canada, Montreal, Quebec, Canada.
Gaumond MH; Shriners Hospitals for Children - Canada, Montreal, Quebec, Canada.
Oh CD; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, 60612, USA.
Yasuda H; Department of Genetics, University of Texas, MD Anderson Cancer Center, Houston, TX, 77030, USA.
Moffatt P; Shriners Hospitals for Children - Canada, Montreal, Quebec, Canada. .; Department of Human Genetics, McGill University, Montreal, Quebec, Canada. .; Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2020 May 08; Vol. 10 (1), pp. 7790. Date of Electronic Publication: 2020 May 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation*
Chondrocytes/*metabolism
Membrane Proteins/*genetics
Membrane Proteins/*metabolism
Proteoglycans/*genetics
Proteoglycans/*metabolism
SOX9 Transcription Factor/*metabolism
Amino Acid Sequence ; Animals ; Base Sequence ; Cell Line ; Cells, Cultured ; Chondroitin Sulfates/metabolism ; Humans ; Membrane Proteins/chemistry ; Mice ; Mice, Transgenic ; Open Reading Frames ; Protein Binding ; Protein Domains ; Proteoglycans/chemistry ; Rats ; Transcription Initiation Site ; Transcription, Genetic
Czasopismo naukowe
Tytuł:
Comparative analysis demonstrates cell type-specific conservation of SOX9 targets between mouse and chicken.
Autorzy:
Yamashita S; Department of Systems BioMedicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.; Department of Systems BioMedicine, National Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.
Kataoka K; Department of Systems BioMedicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.; Research Fellow of Japan Society for the Promotion of Science, Tokyo, Japan.
Yamamoto H; Department of Systems BioMedicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.; Department of Anesthesiology, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
Kato T; Department of Systems BioMedicine, National Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.
Hara S; Department of Systems BioMedicine, National Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.
Yamaguchi K; Functional Genomics Facility, National Institute for Basic Biology, 38, Nishigonaka Myodaiji, Okazaki, Aichi, 444-8585, Japan.
Renard-Guillet C; Laboratory of Genome Structure and Function Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.
Katou Y; Laboratory of Genome Structure and Function Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.
Shirahige K; Laboratory of Genome Structure and Function Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.
Ochi H; Institute for Promotion of Medical Science Research, Faculty of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan.
Ogino H; Amphibian Research Center, Hiroshima University, 1-3-1 Kagami-yama, Higashi-Hiroshima, Hiroshima, 739-8526, Japan.
Uchida T; Department of Anesthesiology, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
Inui M; Department of Systems BioMedicine, National Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.; Laboratory of Animal Regeneration Systemology, Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashi-Mita Tama-ku, Kawasaki, Kanagawa, 214-8571, Japan.
Takada S; Department of Systems BioMedicine, National Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.
Shigenobu S; Functional Genomics Facility, National Institute for Basic Biology, 38, Nishigonaka Myodaiji, Okazaki, Aichi, 444-8585, Japan. .
Asahara H; Department of Systems BioMedicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan. .; Department of Molecular Medicine, The Scripps Research Institute, California, 92037, USA. .; AMED-CREST, Japan Agency for Medical Research and Development (AMED), Tokyo, Japan. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2019 Aug 29; Vol. 9 (1), pp. 12560. Date of Electronic Publication: 2019 Aug 29.
Typ publikacji:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Conserved Sequence*
Chondrocytes/*metabolism
SOX9 Transcription Factor/*metabolism
Sertoli Cells/*metabolism
Animals ; Base Sequence ; Binding Sites ; Chickens ; Chondrocytes/cytology ; Male ; Mice ; Protein Binding ; Sertoli Cells/cytology ; Substrate Specificity
Czasopismo naukowe
Tytuł:
Activation of hepatic stem cells compartment during hepatocarcinogenesis in a HBsAg HBV-transgenic mouse model.
Autorzy:
Anfuso B; Fondazione Italiana Fegato, AREA Science Park Basovizza, SS14 km 163.5, 34149, Trieste, Italy.
El-Khobar KE; Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, 10430, Jakarta, Indonesia.
Ie SI; Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, 10430, Jakarta, Indonesia.
Avellini C; Department of Medical and Biological Sciences, University Hospital, Piazzale Santa Maria della Misericordia 15, 33100, Udine, Italy.
Radillo O; Laboratory of Clinical Analysis, Children Hospital Burlo Garofolo IRCCS, Via dell'Istria, 65, 34137, Trieste, Italy.
Raseni A; Laboratory of Clinical Analysis, Children Hospital Burlo Garofolo IRCCS, Via dell'Istria, 65, 34137, Trieste, Italy.
Tiribelli C; Fondazione Italiana Fegato, AREA Science Park Basovizza, SS14 km 163.5, 34149, Trieste, Italy.
Sukowati CHC; Fondazione Italiana Fegato, AREA Science Park Basovizza, SS14 km 163.5, 34149, Trieste, Italy. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2018 Sep 03; Vol. 8 (1), pp. 13168. Date of Electronic Publication: 2018 Sep 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Biomarkers, Tumor/*genetics
Carcinogenesis/*genetics
Carcinoma, Hepatocellular/*genetics
Hepatitis B Surface Antigens/*genetics
Hepatocytes/*metabolism
Liver Neoplasms/*genetics
Neoplastic Stem Cells/*metabolism
AC133 Antigen/genetics ; AC133 Antigen/metabolism ; Animals ; Antigens, CD34/genetics ; Antigens, CD34/metabolism ; Antigens, Ly/genetics ; Antigens, Ly/metabolism ; Biomarkers, Tumor/metabolism ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Disease Models, Animal ; Epithelial Cell Adhesion Molecule/genetics ; Epithelial Cell Adhesion Molecule/metabolism ; Gene Expression ; Hepatitis B Surface Antigens/metabolism ; Hepatitis B virus/pathogenicity ; Hepatitis B, Chronic/genetics ; Hepatitis B, Chronic/metabolism ; Hepatitis B, Chronic/pathology ; Hepatitis B, Chronic/virology ; Hepatocytes/pathology ; Humans ; Keratin-19/genetics ; Keratin-19/metabolism ; Liver/metabolism ; Liver/pathology ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Male ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Transgenic ; Neoplastic Stem Cells/pathology ; Receptors, Peptide/genetics ; Receptors, Peptide/metabolism ; SOX9 Transcription Factor/genetics ; SOX9 Transcription Factor/metabolism ; Stem Cells/metabolism ; Stem Cells/pathology ; Transaminases/blood ; Transaminases/genetics
Czasopismo naukowe
Tytuł:
Steroidogenic Factor 1 (Nr5a1) is Required for Sertoli Cell Survival Post Sex Determination.
Autorzy:
Anamthathmakula P; Department of Obstetrics and Gynecology, Wayne State University Perinatal Initiative, School of Medicine, Wayne State University, Mott Center for Growth and Development, Detroit, MI, USA.
Miryala CSJ; Department of Obstetrics and Gynecology, Wayne State University Perinatal Initiative, School of Medicine, Wayne State University, Mott Center for Growth and Development, Detroit, MI, USA.
Moreci RS; Department of Cell Biology, Duke University, Durham, NC, 27708, USA.
Kyathanahalli C; Department of Obstetrics and Gynecology, Wayne State University Perinatal Initiative, School of Medicine, Wayne State University, Mott Center for Growth and Development, Detroit, MI, USA.
Hassan SS; Department of Obstetrics and Gynecology, Wayne State University Perinatal Initiative, School of Medicine, Wayne State University, Mott Center for Growth and Development, Detroit, MI, USA.
Condon JC; Department of Obstetrics and Gynecology, Wayne State University Perinatal Initiative, School of Medicine, Wayne State University, Mott Center for Growth and Development, Detroit, MI, USA.
Jeyasuria P; Department of Obstetrics and Gynecology, Wayne State University Perinatal Initiative, School of Medicine, Wayne State University, Mott Center for Growth and Development, Detroit, MI, USA. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2019 Mar 14; Vol. 9 (1), pp. 4452. Date of Electronic Publication: 2019 Mar 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Sertoli Cells/*cytology
Steroidogenic Factor 1/*metabolism
Testis/*cytology
Testis/*embryology
Animals ; Anti-Mullerian Hormone/metabolism ; Apoptosis/genetics ; Cell Survival ; Female ; Gene Expression Regulation, Developmental ; Integrases/genetics ; Male ; Mice, Knockout ; Proto-Oncogene Proteins c-mdm2/genetics ; Proto-Oncogene Proteins c-mdm2/metabolism ; SOX9 Transcription Factor/genetics ; Sertoli Cells/physiology ; Sex Determination Processes ; Steroidogenic Factor 1/genetics ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies