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Wyszukujesz frazę ""STAT1 Transcription Factor"" wg kryterium: Temat


Tytuł :
Cytotoxicity of apigenin toward multiple myeloma cell lines and suppression of iNOS and COX-2 expression in STAT1-transfected HEK293 cells.
Autorzy :
Adham AN; Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Abdelfatah S; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Naqishbandi AM; Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq. Electronic address: .
Mahmoud N; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Jan; Vol. 80, pp. 153371. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Apigenin/*pharmacology
Cyclooxygenase 2/*metabolism
Multiple Myeloma/*drug therapy
Nitric Oxide Synthase Type II/*antagonists & inhibitors
STAT1 Transcription Factor/*genetics
Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Apigenin/administration & dosage ; Apoptosis/drug effects ; Autophagy/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Computational Biology/methods ; Dose-Response Relationship, Drug ; Doxorubicin/administration & dosage ; HEK293 Cells ; Humans ; Multiple Myeloma/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Reactive Oxygen Species/metabolism ; STAT1 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
Maternal exposure to Di-n-butyl phthalate (DBP) aggravate gestational diabetes mellitus via FoxM1 suppression by pSTAT1 signalling.
Autorzy :
Chen M; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China.
Zhao S; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China.
Guo WH; Pathology Center, Shanghai General Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China.
Zhu YP; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China.
Pan L; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China.
Xie ZW; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China.
Sun WL; Department of Geriatrics, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China. Electronic address: .
Jiang JT; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080, China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Dec 01; Vol. 205, pp. 111154. Date of Electronic Publication: 2020 Aug 15.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Experimental/*chemically induced
Diabetes, Gestational/*chemically induced
Dibutyl Phthalate/*toxicity
Endocrine Disruptors/*toxicity
Forkhead Box Protein M1/*metabolism
Maternal Exposure/*adverse effects
STAT1 Transcription Factor/*metabolism
Animals ; Cells, Cultured ; Diabetes Mellitus, Experimental/metabolism ; Diabetes, Gestational/metabolism ; Female ; Forkhead Box Protein M1/genetics ; Gene Expression/drug effects ; Humans ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Male ; Phosphorylation ; Pregnancy ; Primary Cell Culture ; Rats ; Rats, Sprague-Dawley ; STAT1 Transcription Factor/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Signal transducer and activator of transcription 1 gain-of-function with refractory hemophagocytic lymphohistiocytosis.
Autorzy :
Eng V; Department of Allergy and Immunology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California. Electronic address: .
Zomorodian TJ; Department of Hematology and Oncology, Kaiser Permanente Downey Medical Center, Downey, California.
Samant SA; Department of Allergy and Immunology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California.
Maarup TJ; Department of Genetics, Kaiser Permanente Downey Medical Center, Downey, California.
Sheikh J; Department of Allergy and Immunology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California.
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Źródło :
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology [Ann Allergy Asthma Immunol] 2020 Nov; Vol. 125 (5), pp. 605-607.e1. Date of Electronic Publication: 2020 Jul 03.
Typ publikacji :
Case Reports; Letter
MeSH Terms :
Gain of Function Mutation*
Hematopoietic Stem Cell Transplantation/*adverse effects
Lymphohistiocytosis, Hemophagocytic/*genetics
STAT1 Transcription Factor/*genetics
Child ; Child, Preschool ; Hashimoto Disease/etiology ; Humans ; Lymphohistiocytosis, Hemophagocytic/immunology ; Lymphohistiocytosis, Hemophagocytic/surgery ; Male ; STAT1 Transcription Factor/immunology
Raport
Tytuł :
Attenuated Interferon and Proinflammatory Response in SARS-CoV-2-Infected Human Dendritic Cells Is Associated With Viral Antagonism of STAT1 Phosphorylation.
Autorzy :
Yang D; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Chu H; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Hou Y; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Chai Y; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Shuai H; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Lee AC; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Zhang X; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Wang Y; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Hu B; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Huang X; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Yuen TT; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Cai JP; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Zhou J; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Yuan S; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Zhang AJ; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Chan JF; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Carol Yu Centre for Infection, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.; Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, China.; Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University, Haikou, Hainan, and The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
Yuen KY; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Carol Yu Centre for Infection, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.; Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, China.; Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University, Haikou, Hainan, and The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
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Źródło :
The Journal of infectious diseases [J Infect Dis] 2020 Aug 04; Vol. 222 (5), pp. 734-745.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Betacoronavirus/*physiology
Coronavirus Infections/*immunology
Dendritic Cells/*immunology
Interferons/*immunology
Monocytes/*immunology
Pneumonia, Viral/*immunology
STAT1 Transcription Factor/*antagonists & inhibitors
Adaptive Immunity ; Animals ; Betacoronavirus/immunology ; Betacoronavirus/isolation & purification ; Betacoronavirus/metabolism ; COVID-19 ; Chemokines/metabolism ; Chlorocebus aethiops ; Coronavirus Infections/metabolism ; Coronavirus Infections/virology ; Cytokines/metabolism ; Dendritic Cells/metabolism ; Dendritic Cells/virology ; Humans ; Macrophages/immunology ; Macrophages/virology ; Monocytes/virology ; Pandemics ; Phosphorylation ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/virology ; SARS-CoV-2 ; STAT1 Transcription Factor/immunology ; STAT1 Transcription Factor/metabolism ; Vero Cells ; Virus Replication/physiology ; Virus Shedding
Czasopismo naukowe
Tytuł :
Selective Interferon Responses of Intestinal Epithelial Cells Minimize Tumor Necrosis Factor Alpha Cytotoxicity.
Autorzy :
Van Winkle JA; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Constant DA; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Li L; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Nice TJ; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA .
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Źródło :
Journal of virology [J Virol] 2020 Oct 14; Vol. 94 (21). Date of Electronic Publication: 2020 Oct 14 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytokines/*immunology
Intestinal Mucosa/*immunology
Rotavirus Infections/*immunology
STAT1 Transcription Factor/*immunology
STAT2 Transcription Factor/*immunology
Tumor Necrosis Factor-alpha/*toxicity
Animals ; Animals, Newborn ; Cytokines/genetics ; Epithelial Cells/drug effects ; Epithelial Cells/immunology ; Epithelial Cells/virology ; Gene Expression Regulation ; Humans ; Interferon-Stimulated Gene Factor 3, gamma Subunit/genetics ; Interferon-Stimulated Gene Factor 3, gamma Subunit/immunology ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/virology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Organoids/drug effects ; Organoids/immunology ; Organoids/virology ; Response Elements ; Rotavirus/drug effects ; Rotavirus/growth & development ; Rotavirus/pathogenicity ; Rotavirus Infections/genetics ; Rotavirus Infections/pathology ; Rotavirus Infections/virology ; STAT1 Transcription Factor/genetics ; STAT2 Transcription Factor/genetics ; Signal Transduction ; Virus Replication
Czasopismo naukowe
Tytuł :
STAT1 deficiency predisposes to spontaneous otitis media.
Autorzy :
Bodmer D; Department of Biomedicine and Clinic for Otolaryngology, Head and Neck Surgery, University Basel Hospital, Basel, Switzerland.
Kern P; Department of Biomedicine and Clinic for Otolaryngology, Head and Neck Surgery, University Basel Hospital, Basel, Switzerland.
Bächinger D; Department of Otorhinolaryngology, Head and Neck Surgery, University of Zurich, University Hospital Zurich, Zurich, Switzerland.
Monge Naldi A; Department of Otorhinolaryngology, Head and Neck Surgery, University of Zurich, University Hospital Zurich, Zurich, Switzerland.
Levano Huaman S; Department of Biomedicine and Clinic for Otolaryngology, Head and Neck Surgery, University Basel Hospital, Basel, Switzerland.
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Źródło :
PloS one [PLoS One] 2020 Sep 29; Vol. 15 (9), pp. e0239952. Date of Electronic Publication: 2020 Sep 29 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Otitis Media/*genetics
STAT1 Transcription Factor/*genetics
Animals ; Cochlea/pathology ; Cochlea/physiopathology ; Ear, Middle/pathology ; Ear, Middle/physiopathology ; Evoked Potentials, Auditory, Brain Stem ; Mice ; Mice, Inbred C57BL ; STAT1 Transcription Factor/deficiency
Czasopismo naukowe
Tytuł :
Lyssavirus P-protein selectively targets STAT3-STAT1 heterodimers to modulate cytokine signalling.
Autorzy :
Harrison AR; Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Lieu KG; Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Parkville, Victoria, Australia.
Larrous F; Lyssavirus Epidemiology and Neuropathology Unit, Institut Pasteur, Paris, France.
Ito N; Laboratory of Zoonotic Diseases, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
Bourhy H; Lyssavirus Epidemiology and Neuropathology Unit, Institut Pasteur, Paris, France.
Moseley GW; Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Sep 09; Vol. 16 (9), pp. e1008767. Date of Electronic Publication: 2020 Sep 09 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Cytokines/*metabolism
Lyssavirus/*immunology
Rhabdoviridae Infections/*immunology
STAT1 Transcription Factor/*metabolism
STAT3 Transcription Factor/*metabolism
Viral Proteins/*metabolism
HEK293 Cells ; HeLa Cells ; Humans ; Interleukin-6/metabolism ; Rhabdoviridae Infections/metabolism ; Rhabdoviridae Infections/virology ; STAT1 Transcription Factor/genetics ; STAT3 Transcription Factor/genetics ; Trans-Activators ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Association between the methylation of the STAT1 and SOCS3 in peripheral blood and gastric cancer.
Autorzy :
Han Q; Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, China.
Zhou H; Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, China.
Xie W; Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, China.
Sun T; Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, China.
Wei R; Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, China.
Nie C; Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, China.
Hong J; Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, China.
Zhu L; Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, China.
Tian W; Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, China.
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Źródło :
Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2020 Aug; Vol. 35 (8), pp. 1347-1354. Date of Electronic Publication: 2020 Mar 07.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Association Studies*
DNA Methylation/*genetics
Genetic Predisposition to Disease/*genetics
STAT1 Transcription Factor/*genetics
Stomach Neoplasms/*genetics
Suppressor of Cytokine Signaling 3 Protein/*genetics
Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Risk ; STAT1 Transcription Factor/blood ; Suppressor of Cytokine Signaling 3 Protein/blood
Czasopismo naukowe
Tytuł :
Ruxolitinib treatment of a patient with steroid-dependent severe autoimmunity due to STAT1 gain-of-function mutation.
Autorzy :
Moriya K; Department of Pediatrics, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan. .
Suzuki T; Department of Pediatrics, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan.
Uchida N; Department of Pediatrics, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan.
Nakano T; Department of Pediatrics, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan.
Katayama S; Department of Pediatrics, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan.
Irie M; Department of Pediatrics, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan.
Rikiishi T; Department of Pediatrics, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan.
Niizuma H; Department of Pediatrics, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan.
Okada S; Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Imai K; Department of Community Pediatrics, Perinatal and Maternal Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Sasahara Y; Department of Pediatrics, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan.
Kure S; Department of Pediatrics, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan.
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Źródło :
International journal of hematology [Int J Hematol] 2020 Aug; Vol. 112 (2), pp. 258-262. Date of Electronic Publication: 2020 Mar 16.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Candidiasis, Chronic Mucocutaneous/*drug therapy
Candidiasis, Chronic Mucocutaneous/*immunology
Gain of Function Mutation/*genetics
Protein Kinase Inhibitors/*administration & dosage
Pyrazoles/*administration & dosage
STAT1 Transcription Factor/*genetics
Autoimmunity ; Candidiasis, Chronic Mucocutaneous/genetics ; Cytokines/metabolism ; Humans ; Infant ; Janus Kinase 1/antagonists & inhibitors ; Male ; Phosphorylation ; STAT1 Transcription Factor/metabolism ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Sevoflurane reduces inflammatory factor expression, increases viability and inhibits apoptosis of lung cells in acute lung injury by microRNA-34a-3p upregulation and STAT1 downregulation.
Autorzy :
Yuan J; Department of Anaesthesia, Henan Provincial People's Hospital, Zhengzhou, 450003, Henan, China; Department of Anaesthesia of Central China Fuwai Hospital, Zhengzhou, 450003, Henan, China; Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, China; School of Clinical Medicine, Henan University, Zhengzhou, Henan, 450003, China.
Zhang Y; Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, China; School of Clinical Medicine, Henan University, Zhengzhou, Henan, 450003, China; Heart Cental of Henan Provincial People's Hospital, Zhengzhou, 450003, Henan, China; Central China Fuwai Hospital, Zhengzhou, 450003, Henan, China. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2020 May 01; Vol. 322, pp. 109027. Date of Electronic Publication: 2020 Mar 06.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*/drug effects
Lung/*metabolism
MicroRNAs/*metabolism
STAT1 Transcription Factor/*metabolism
Sevoflurane/*administration & dosage
Acute Lung Injury/etiology ; Acute Lung Injury/metabolism ; Acute Lung Injury/veterinary ; Administration, Inhalation ; Animals ; Antagomirs/metabolism ; Cell Survival/drug effects ; Down-Regulation/drug effects ; Lipopolysaccharides/toxicity ; Lung/pathology ; Male ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/genetics ; Oxidative Stress/drug effects ; Peroxidase/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; Rats ; Rats, Sprague-Dawley ; STAT1 Transcription Factor/antagonists & inhibitors ; STAT1 Transcription Factor/genetics ; Sevoflurane/pharmacology ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Histone methyltransferase SETDB1 promotes colorectal cancer proliferation through the STAT1-CCND1/CDK6 axis.
Autorzy :
Yu L; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ye F; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Li YY; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhan YZ; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Liu Y; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yan HM; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Fang Y; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xie YW; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhang FJ; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Chen LH; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ding Y; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Chen KL; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.; HuiQiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
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Źródło :
Carcinogenesis [Carcinogenesis] 2020 Jul 10; Vol. 41 (5), pp. 678-688.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*
Biomarkers, Tumor/*metabolism
Colorectal Neoplasms/*pathology
Cyclin D1/*metabolism
Cyclin-Dependent Kinase 6/*metabolism
Histone-Lysine N-Methyltransferase/*metabolism
STAT1 Transcription Factor/*metabolism
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Movement ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Cyclin D1/genetics ; Cyclin-Dependent Kinase 6/genetics ; Gene Expression Regulation, Neoplastic ; Histone-Lysine N-Methyltransferase/genetics ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; STAT1 Transcription Factor/genetics ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
PD-L1 upregulation by IFN-α/γ-mediated Stat1 suppresses anti-HBV T cell response.
Autorzy :
Liu L; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Institute of Microbiology, Beijing, China.; Institutes of Physical Science and Information Technology, Anhui University, Hefei, China.
Hou J; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Institute of Microbiology, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Xu Y; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Institute of Microbiology, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Qin L; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Institute of Microbiology, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Liu W; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Institute of Microbiology, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Zhang H; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Institute of Microbiology, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Li Y; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Institute of Microbiology, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Chen M; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Institute of Microbiology, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Deng M; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Institute of Microbiology, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Zhao B; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Institute of Microbiology, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Hu J; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Institute of Microbiology, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Zheng H; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Institute of Microbiology, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Li C; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Institute of Microbiology, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Meng S; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Institute of Microbiology, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
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Źródło :
PloS one [PLoS One] 2020 Jul 06; Vol. 15 (7), pp. e0228302. Date of Electronic Publication: 2020 Jul 06 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B7-H1 Antigen/*metabolism
Hepatitis B virus/*immunology
Interferon-alpha/*pharmacology
Interferon-gamma/*pharmacology
STAT1 Transcription Factor/*metabolism
T-Lymphocytes/*immunology
Up-Regulation/*drug effects
Animals ; Antibodies, Monoclonal/therapeutic use ; B7-H1 Antigen/chemistry ; B7-H1 Antigen/genetics ; B7-H1 Antigen/immunology ; Binding Sites ; Cell Line ; Hepatitis B/drug therapy ; Hepatitis B/veterinary ; Hepatitis B Surface Antigens/blood ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Programmed Cell Death 1 Receptor/metabolism ; Promoter Regions, Genetic ; STAT1 Transcription Factor/chemistry ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex-mediated STAT1 downregulation.
Autorzy :
Zhan X; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.; China Military Institute of Chinese Materia, the Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Guo S; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Li Y; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Ran H; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Huang H; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Mi L; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Wu J; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Wang X; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Xiao D; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Chen L; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Li D; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Zhang S; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Yan X; The First Hospital of Jilin University, Changchun, China.
Yu Y; The First Hospital of Jilin University, Changchun, China.
Li T; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Han Q; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
He K; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Cui J; The First Hospital of Jilin University, Changchun, China.
Li T; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Zhou T; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
Rich JN; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA.
Bao S; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.; Center for Cancer Stem Cell Research, Lerner Research Institute, Cleveland, OH.; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH.
Zhang X; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, National Center of Biomedical Analysis, Beijing, China.; The First Hospital of Jilin University, Changchun, China.
Li A; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.; The First Hospital of Jilin University, Changchun, China.
Man J; State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2020 May 04; Vol. 217 (5).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*/genetics
DNA-Binding Proteins/*metabolism
Glioma/*pathology
Interferons/*metabolism
Mi-2 Nucleosome Remodeling and Deacetylase Complex/*metabolism
Neoplastic Stem Cells/*metabolism
STAT1 Transcription Factor/*metabolism
Acetylation ; Aged ; Carcinogenesis/genetics ; Carcinogenesis/pathology ; Cell Line, Tumor ; Cell Proliferation ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Glioma/genetics ; Histones/metabolism ; Humans ; Lysine/metabolism ; Male ; Middle Aged ; Neoplastic Stem Cells/pathology ; Promoter Regions, Genetic/genetics ; STAT1 Transcription Factor/genetics ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
Rilpivirine attenuates liver fibrosis through selective STAT1-mediated apoptosis in hepatic stellate cells.
Autorzy :
Martí-Rodrigo A; Department of Pharmacology, Faculty of Medicine, University of Valencia-CIBERehd, Valencia, Spain.
Alegre F; Department of Pharmacology, Faculty of Medicine, University of Valencia-CIBERehd, Valencia, Spain.; FISABIO-Hospital Universitario Dr. Peset, Valencia, Spain.
Moragrega ÁB; Department of Pharmacology, Faculty of Medicine, University of Valencia-CIBERehd, Valencia, Spain.
García-García F; Bioinformatics & Biostatistics Unit, Principe Felipe Research Center, Valencia, Spain.
Martí-Rodrigo P; Department of Pharmacology, Faculty of Medicine, University of Valencia-CIBERehd, Valencia, Spain.
Fernández-Iglesias A; Liver Vascular Biology Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-CIBERehd, Barcelona, Spain.
Gracia-Sancho J; Liver Vascular Biology Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-CIBERehd, Barcelona, Spain.; Hepatology, Department of Biomedical Research, Inselspital, University of Bern, Bern, Switzerland.
Apostolova N; Department of Pharmacology, Faculty of Medicine, University of Valencia-CIBERehd, Valencia, Spain.
Esplugues JV; Department of Pharmacology, Faculty of Medicine, University of Valencia-CIBERehd, Valencia, Spain.; FISABIO-Hospital Universitario Dr. Peset, Valencia, Spain.
Blas-García A; Department of Pharmacology, Faculty of Medicine, University of Valencia-CIBERehd, Valencia, Spain .
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Źródło :
Gut [Gut] 2020 May; Vol. 69 (5), pp. 920-932. Date of Electronic Publication: 2019 Sep 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Hepatic Stellate Cells/*drug effects
Liver Regeneration/*drug effects
Non-alcoholic Fatty Liver Disease/*drug therapy
Rilpivirine/*pharmacology
STAT1 Transcription Factor/*drug effects
STAT3 Transcription Factor/*drug effects
Animals ; Apoptosis/drug effects ; Cells, Cultured ; Disease Models, Animal ; Humans ; Liver Cirrhosis/pathology ; Mice ; Non-alcoholic Fatty Liver Disease/pathology ; Risk Assessment ; STAT1 Transcription Factor/metabolism ; Sensitivity and Specificity ; Treatment Outcome
Czasopismo naukowe
Tytuł :
The T1D-associated lncRNA Lnc13 modulates human pancreatic β cell inflammation by allele-specific stabilization of STAT1 mRNA.
Autorzy :
Gonzalez-Moro I; Department of Biochemistry and Molecular Biology, University of the Basque Country, 48940 Leioa, Spain.
Olazagoitia-Garmendia A; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, 48940 Leioa, Spain.; Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain.
Colli ML; ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Cobo-Vuilleumier N; Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER (Centro Andaluz de Biología Molecular y Medicina Regenerativa), Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, 41092 Seville, Spain.
Postler TS; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York 10032.
Marselli L; Department of Clinical and Experimental Medicine, Cisanello University Hospital, 56126 Pisa, Italy.
Marchetti P; Department of Clinical and Experimental Medicine, Cisanello University Hospital, 56126 Pisa, Italy.
Ghosh S; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York 10032.
Gauthier BR; Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER (Centro Andaluz de Biología Molecular y Medicina Regenerativa), Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, 41092 Seville, Spain.; CIBER (Centro de Investigación Biomédica en Red) de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Eizirik DL; ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles, 1070 Brussels, Belgium.; Indiana Biosciences Research Institute, Indianapolis, IN, 46202.
Castellanos-Rubio A; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, 48940 Leioa, Spain; .; Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain.; CIBER (Centro de Investigación Biomédica en Red) de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain.; CIBER (Centro de Investigación Biomédica en Red) de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Santin I; Department of Biochemistry and Molecular Biology, University of the Basque Country, 48940 Leioa, Spain; .; Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain.; CIBER (Centro de Investigación Biomédica en Red) de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Apr 21; Vol. 117 (16), pp. 9022-9031. Date of Electronic Publication: 2020 Apr 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Type 1/*genetics
Insulin-Secreting Cells/*immunology
RNA, Long Noncoding/*metabolism
RNA-Binding Proteins/*metabolism
STAT1 Transcription Factor/*genetics
3' Untranslated Regions/genetics ; Cell Survival/genetics ; Diabetes Mellitus, Type 1/immunology ; Diabetes Mellitus, Type 1/virology ; Genetic Predisposition to Disease ; HEK293 Cells ; Humans ; Insulin-Secreting Cells/pathology ; Insulin-Secreting Cells/virology ; Jurkat Cells ; Poly I-C/immunology ; Polymorphism, Single Nucleotide ; Primary Cell Culture ; RNA Stability/genetics ; RNA, Messenger/metabolism ; RNA, Viral/immunology ; STAT1 Transcription Factor/immunology ; STAT1 Transcription Factor/metabolism ; Signal Transduction/genetics ; Signal Transduction/immunology ; Up-Regulation/immunology
Czasopismo naukowe
Tytuł :
Human gain-of-function STAT1 mutation disturbs IL-17 immunity in mice.
Autorzy :
Tamaura M; Department of Pediatrics, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Satoh-Takayama N; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Tsumura M; Department of Pediatrics, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Sasaki T; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Goda S; Department of Pediatrics, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Kageyama T; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Hayakawa S; Department of Pediatrics, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Kimura S; Department of Pediatrics, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Asano T; Department of Pediatrics, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Nakayama M; Department of Frontier Research and Development, Kazusa DNA Research Institute, Kisarazu, Japan.
Koseki H; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Ohara O; Department of Applied Genomics, Kazusa DNA Research Institute, Kisarazu, Japan.; Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Okada S; Department of Pediatrics, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Ohno H; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Division of Immunobiology, Department of Medical Life Science, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.
Kobayashi M; Department of Pediatrics, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
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Źródło :
International immunology [Int Immunol] 2020 Apr 12; Vol. 32 (4), pp. 259-272.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gain of Function Mutation/*genetics
Interleukin-17/*immunology
STAT1 Transcription Factor/*genetics
Animals ; Candida albicans/immunology ; Humans ; Interleukin-17/biosynthesis ; Mice ; Mice, Inbred C57BL ; STAT1 Transcription Factor/immunology ; Th17 Cells
Czasopismo naukowe
Tytuł :
Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations.
Autorzy :
Austin RJ; Cancer Program, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, QLD, 3006, Australia.; The University of Queensland, St Lucia, QLD, 4072, Australia.
Straube J; Cancer Program, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, QLD, 3006, Australia.
Bruedigam C; Cancer Program, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, QLD, 3006, Australia.
Pali G; Cancer Program, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, QLD, 3006, Australia.
Jacquelin S; Cancer Program, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, QLD, 3006, Australia.
Vu T; Cancer Program, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, QLD, 3006, Australia.
Green J; Cancer Program, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, QLD, 3006, Australia.
Gräsel J; Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120, Heidelberg, Germany.
Lansink L; Cancer Program, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, QLD, 3006, Australia.
Cooper L; Cancer Program, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, QLD, 3006, Australia.
Lee SJ; PharmaEssentia Co, Taipei, Taiwan.
Chen NT; PharmaEssentia Co, Taipei, Taiwan.
Lee CW; PharmaEssentia, USA, LLC, Burlington, MA, USA.
Haque A; Cancer Program, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, QLD, 3006, Australia.
Heidel FH; Leibniz-Institute on Aging-Fritz Lipmann Institute (FLI), Beutenbergstrasse 11, 07745, Jena, Germany.; Innere Medizin 2, Hämatologie und Onkologie, Universitätsklinikum Jena, 07747, Jena, Germany.
D'Andrea R; Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia.
Hill GR; Cancer Program, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, QLD, 3006, Australia.; Fred Hutchinson Cancer Centre, Seattle Cancer Care Alliance, Seattle, WA, USA.
Mullally A; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Milsom MD; Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120, Heidelberg, Germany.
Bywater M; Cancer Program, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, QLD, 3006, Australia. .; The University of Queensland, St Lucia, QLD, 4072, Australia. .
Lane SW; Cancer Program, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, QLD, 3006, Australia. .; The University of Queensland, St Lucia, QLD, 4072, Australia. .; Cancer Care Services, Royal Brisbane and Women's Hospital, Cnr Butterfield St and Bowen Bridge Rd, Herston, QLD, 4029, Australia. .
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Źródło :
Leukemia [Leukemia] 2020 Apr; Vol. 34 (4), pp. 1075-1089. Date of Electronic Publication: 2019 Nov 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Hematopoietic Stem Cells/*drug effects
Interferon-alpha/*pharmacology
Janus Kinase 2/*genetics
Myeloproliferative Disorders/*drug therapy
Pyrazoles/*pharmacology
STAT1 Transcription Factor/*metabolism
Animals ; Antiviral Agents/pharmacology ; Cell Proliferation ; Cells, Cultured ; Drug Therapy, Combination ; Female ; Hematopoietic Stem Cells/metabolism ; Hematopoietic Stem Cells/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myeloproliferative Disorders/genetics ; Myeloproliferative Disorders/pathology ; STAT1 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
CD8 T Cells and STAT1 Signaling Are Essential Codeterminants in Protection from Polyomavirus Encephalopathy.
Autorzy :
Mockus TE; Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Netherby-Winslow CS; Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Atkins HM; Department of Comparative Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Lauver MD; Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Jin G; Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Ren HM; Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Lukacher AE; Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, Pennsylvania, USA .
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Źródło :
Journal of virology [J Virol] 2020 Mar 31; Vol. 94 (8). Date of Electronic Publication: 2020 Mar 31 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Polyomavirus/*immunology
Polyomavirus Infections/*immunology
STAT1 Transcription Factor/*immunology
Adaptive Immunity ; Animals ; Brain/pathology ; Brain/virology ; Brain Diseases/pathology ; Brain Diseases/virology ; Choroid Plexus ; Disease Models, Animal ; Female ; Humans ; Immunity, Innate ; JC Virus/immunology ; Leukoencephalopathy, Progressive Multifocal/virology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Polyomavirus Infections/mortality ; Polyomavirus Infections/virology ; STAT1 Transcription Factor/genetics ; Signal Transduction ; Spleen/pathology ; Spleen/virology ; Viral Load
Czasopismo naukowe
Tytuł :
STAT1 inhibits T-cell exhaustion and myeloid derived suppressor cell accumulation to promote antitumor immune responses in head and neck squamous cell carcinoma.
Autorzy :
Ryan N; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH.
Anderson K; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH.
Volpedo G; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH.; Department of Microbiology, The Ohio State University, Columbus, OH.
Hamza O; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH.
Varikuti S; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH.
Satoskar AR; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH.; Department of Microbiology, The Ohio State University, Columbus, OH.
Oghumu S; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH.
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Źródło :
International journal of cancer [Int J Cancer] 2020 Mar 15; Vol. 146 (6), pp. 1717-1729. Date of Electronic Publication: 2019 Nov 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunomodulation*
Myeloid-Derived Suppressor Cells/*immunology
Myeloid-Derived Suppressor Cells/*metabolism
STAT1 Transcription Factor/*metabolism
Squamous Cell Carcinoma of Head and Neck/*etiology
Squamous Cell Carcinoma of Head and Neck/*metabolism
T-Lymphocytes/*immunology
T-Lymphocytes/*metabolism
Animals ; Cell Line, Tumor ; Disease Models, Animal ; Disease Progression ; Female ; Humans ; Lymph Nodes/pathology ; Male ; Mice ; Mice, Knockout ; Neoplasm Metastasis ; Neoplasm Staging ; STAT1 Transcription Factor/deficiency ; Squamous Cell Carcinoma of Head and Neck/pathology ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
STAT1 upregulates glutaminase and modulates amino acids and glutathione metabolism.
Autorzy :
Kondo S; Division of Chemotherapy, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan. Electronic address: .
Kato Y; Division of Chemotherapy, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.
Minagawa S; Division of Chemotherapy, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.
Sugimoto Y; Division of Chemotherapy, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Mar 12; Vol. 523 (3), pp. 672-677. Date of Electronic Publication: 2020 Jan 14.
Typ publikacji :
Journal Article
MeSH Terms :
Up-Regulation*
Amino Acids/*metabolism
Glutaminase/*genetics
Glutathione/*metabolism
STAT1 Transcription Factor/*genetics
ATP Binding Cassette Transporter, Subfamily B/genetics ; Animals ; Cell Line ; Glutaminase/metabolism ; HEK293 Cells ; Humans ; Mice ; STAT1 Transcription Factor/metabolism
Czasopismo naukowe

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