Temat: "STAT2" - OpacWWW - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition.
Autorzy:: Biswal M; Department of Biochemistry, University of California, Riverside, CA, USA.
Yao W; Department of Microbiology and Plant Pathology, University of California, Riverside, CA, USA.
Lu J; Department of Biochemistry, University of California, Riverside, CA, USA.
Chen J; Department of Biochemistry, University of California, Riverside, CA, USA.
Morrison J; Department of Microbiology and Plant Pathology, University of California, Riverside, CA, USA.
Hai R; Department of Microbiology and Plant Pathology, University of California, Riverside, CA, USA. .
Song J; Department of Biochemistry, University of California, Riverside, CA, USA. .; Pokaż więcej
Źródło:: Communications biology [Commun Biol] 2024 Jan 10; Vol. 7 (1), pp. 76. Date of Electronic Publication: 2024 Jan 10.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Flavivirus*
STAT2 Transcription Factor*/metabolism
Zika Virus*
Zika Virus Infection*
Viral Nonstructural Proteins*/metabolism
Humans ; Proteolysis ; Species Specificity

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Skocz do pozycji: 2.

Tytuł:: ISGF3 and STAT2/IRF9 Control Basal and IFN-Induced Transcription through Genome-Wide Binding of Phosphorylated and Unphosphorylated Complexes to Common ISRE-Containing ISGs.
Autorzy:: Nowicka H; Human Molecular Genetics Research Unit, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, 61-614 Poznan, Poland.
Sekrecka A; Human Molecular Genetics Research Unit, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, 61-614 Poznan, Poland.
Blaszczyk K; Human Molecular Genetics Research Unit, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, 61-614 Poznan, Poland.
Kluzek K; Human Molecular Genetics Research Unit, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, 61-614 Poznan, Poland.
Chang CY; Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Wesoly J; Laboratory of High Throughput Technologies, Faculty of Biology, Adam Mickiewicz University, 61-614 Poznan, Poland.
Lee CK; Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Bluyssen HAR; Human Molecular Genetics Research Unit, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, 61-614 Poznan, Poland.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Dec 18; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 18.
Typ publikacji:: Journal Article
MeSH Terms:: Interferon Type I*/metabolism
Interleukin-1 Receptor-Like 1 Protein*/metabolism
Interferon-Stimulated Gene Factor 3*/metabolism
STAT2 Transcription Factor*/metabolism
Antiviral Agents/pharmacology ; DNA/pharmacology ; Immunoglobulins/metabolism ; Signal Transduction ; STAT1 Transcription Factor/metabolism ; Humans

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Skocz do pozycji: 3.

Tytuł:: Generation of porcine PK-15 cells lacking the Ifnar1 or Stat2 gene to optimize the efficiency of viral isolation.
Autorzy:: Shofa M; Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.; Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, Japan.
Saito A; Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.; Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki, Japan.; Center for Animal Disease Control, University of Miyazaki, Miyazaki, Japan.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Nov 08; Vol. 18 (11), pp. e0289863. Date of Electronic Publication: 2023 Nov 08 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Interferon Type I*/metabolism
Viruses*
Animals ; Swine ; STAT2 Transcription Factor/metabolism ; Cell Line ; Interferon-alpha/metabolism

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Skocz do pozycji: 4.

Tytuł:: Mechanisms of Viral Degradation of Cellular Signal Transducer and Activator of Transcription 2.
Autorzy:: Barik S; EonBio, 3780 Pelham Drive, Mobile, AL 36619, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Jan 01; Vol. 23 (1). Date of Electronic Publication: 2022 Jan 01.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Proteolysis*
STAT2 Transcription Factor/*metabolism
Viruses/*metabolism
Amino Acid Sequence ; Animals ; Humans ; Models, Biological ; Proteasome Endopeptidase Complex/metabolism ; STAT2 Transcription Factor/chemistry ; STAT2 Transcription Factor/ultrastructure ; Ubiquitin/metabolism

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Skocz do pozycji: 5.

Tytuł:: Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2.
Autorzy:: Fanunza E; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Carletti F; Laboratory of Virology, National Institute for Infectious Diseases, L.Spallanzani͟ IRCCS, Rome, Italy.
Quartu M; Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy.
Grandi N; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Ermellino L; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Milia J; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Corona A; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Capobianchi MR; Laboratory of Virology, National Institute for Infectious Diseases, L.Spallanzani͟ IRCCS, Rome, Italy.
Ippolito G; Laboratory of Virology, National Institute for Infectious Diseases, L.Spallanzani͟ IRCCS, Rome, Italy.
Tramontano E; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.; Pokaż więcej
Źródło:: Virulence [Virulence] 2021 Dec; Vol. 12 (1), pp. 1580-1596.
Typ publikacji:: Journal Article
MeSH Terms:: Immune Evasion*
STAT1 Transcription Factor*/genetics
STAT1 Transcription Factor*/metabolism
STAT2 Transcription Factor*/genetics
Viral Nonstructural Proteins*/genetics
Viral Nonstructural Proteins*/metabolism
Zika Virus Infection*/immunology
Interferons/*immunology
Humans ; Immunity, Innate ; Zika Virus

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Skocz do pozycji: 6.

Tytuł:: Nuclear dengue virus NS5 antagonizes expression of PAF1-dependent immune response genes.
Autorzy:: Petit MJ; Department of Microbiology and Molecular Genetics, University of California, Davis, California, United States of America.; Department of Chemical Engineering, University of California, Davis, California, United States of America.
Kenaston MW; Department of Microbiology and Molecular Genetics, University of California, Davis, California, United States of America.
Pham OH; Department of Microbiology and Molecular Genetics, University of California, Davis, California, United States of America.
Nagainis AA; Department of Microbiology and Molecular Genetics, University of California, Davis, California, United States of America.; Department of Chemical Engineering, University of California, Davis, California, United States of America.
Fishburn AT; Department of Microbiology and Molecular Genetics, University of California, Davis, California, United States of America.
Shah PS; Department of Microbiology and Molecular Genetics, University of California, Davis, California, United States of America.; Department of Chemical Engineering, University of California, Davis, California, United States of America.; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2021 Nov 19; Vol. 17 (11), pp. e1010100. Date of Electronic Publication: 2021 Nov 19 (Print Publication: 2021).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Mutation*
Protein Interaction Domains and Motifs*
Dengue/*virology
STAT2 Transcription Factor/*metabolism
Subcellular Fractions/*metabolism
Transcription Factors/*metabolism
Viral Nonstructural Proteins/*metabolism
A549 Cells ; CRISPR-Cas Systems ; Dengue/genetics ; Dengue/metabolism ; Dengue Virus/physiology ; Humans ; RNA-Seq ; STAT2 Transcription Factor/antagonists & inhibitors ; STAT2 Transcription Factor/genetics ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/genetics ; Viral Nonstructural Proteins/genetics

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Skocz do pozycji: 7.

Tytuł:: PRL-3 induces a positive signaling circuit between glycolysis and activation of STAT1/2.
Autorzy:: Vandsemb EN; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Rye MB; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Clinic of Surgery, St. Olavs University Hospital, Trondheim, Norway.; Clinic of Laboratory Medicine, St. Olavs University Hospital, Trondheim, Norway.; Biocore - Bioinformatics Core Facility, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Steiro IJ; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Elsaadi S; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Clinic of Laboratory Medicine, St. Olavs University Hospital, Trondheim, Norway.
Rø TB; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Children's Clinic, St. Olavs University Hospital, Trondheim, Norway.
Slørdahl TS; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Clinic of Medicine, St. Olavs University Hospital, Trondheim, Norway.
Sponaas AM; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Børset M; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Immunology and Transfusion Medicine, St. Olavs University Hospital, Norway.
Abdollahi P; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Clinic of Laboratory Medicine, St. Olavs University Hospital, Trondheim, Norway.; Clinic of Medicine, St. Olavs University Hospital, Trondheim, Norway.; Pokaż więcej
Źródło:: The FEBS journal [FEBS J] 2021 Dec; Vol. 288 (23), pp. 6700-6715. Date of Electronic Publication: 2021 Jun 20.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Transcriptional Activation*
Glycolysis/*genetics
Neoplasm Proteins/*genetics
Protein Tyrosine Phosphatases/*genetics
STAT1 Transcription Factor/*genetics
STAT2 Transcription Factor/*genetics
Signal Transduction/*genetics
Cell Line, Tumor ; Cell Survival/genetics ; Cytokines/genetics ; Cytokines/metabolism ; Exoribonucleases/genetics ; Exoribonucleases/metabolism ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic ; Humans ; Interferon-Stimulated Gene Factor 3, gamma Subunit/genetics ; Interferon-Stimulated Gene Factor 3, gamma Subunit/metabolism ; Neoplasm Proteins/metabolism ; Protein Tyrosine Phosphatases/metabolism ; RNA-Seq/methods ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/metabolism ; Ubiquitins/genetics ; Ubiquitins/metabolism

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Skocz do pozycji: 8.

Tytuł:: Nipah Virus Impairs Autocrine IFN Signaling by Sequestering STAT1 and STAT2 into Inclusion Bodies.
Autorzy:: Becker N; Institute of Virology, Philipps University Marburg, Hans-Meerwein-Str. 2, 35043 Marburg, Germany.
Maisner A; Institute of Virology, Philipps University Marburg, Hans-Meerwein-Str. 2, 35043 Marburg, Germany.; Pokaż więcej
Źródło:: Viruses [Viruses] 2023 Feb 17; Vol. 15 (2). Date of Electronic Publication: 2023 Feb 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Nipah Virus*
Inclusion Bodies, Viral*
Humans ; Antiviral Agents ; Cytosol ; Interferons/metabolism ; STAT1 Transcription Factor ; STAT2 Transcription Factor

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Skocz do pozycji: 9.

Tytuł:: STAT2 Limits Host Species Specificity of Human Metapneumovirus.
Autorzy:: Rogers MC; Department of Pediatrics, University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37212, USA.
Miranda-Katz M; Department of Pediatrics, University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.
Zhang Y; Department of Pediatrics, University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.
Oury TD; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Uccellini MB; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Williams JV; Department of Pediatrics, University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.; Institute for Infection, Inflammation, and Immunity in Children (i4Kids), University of Pittsburgh, Pittsburgh, PA 15224, USA.; Pokaż więcej
Źródło:: Viruses [Viruses] 2020 Jul 04; Vol. 12 (7). Date of Electronic Publication: 2020 Jul 04.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Metapneumovirus/*physiology
Paramyxoviridae Infections/*immunology
STAT2 Transcription Factor/*immunology
Animals ; Female ; Host Specificity ; Humans ; Immunity, Innate ; Interferons/genetics ; Interferons/immunology ; Male ; Metapneumovirus/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Paramyxoviridae Infections/genetics ; Paramyxoviridae Infections/virology ; STAT2 Transcription Factor/genetics ; Th2 Cells

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Skocz do pozycji: 10.

Tytuł:: Characterization of a novel STAT 2 knock-out hamster model of Crimean-Congo hemorrhagic fever virus pathogenesis.
Autorzy:: Ranadheera C; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, MB, Canada.; Bioforensics Assay Development and Diagnostics, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Valcourt EJ; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, MB, Canada.
Warner BM; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, MB, Canada.; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.
Poliquin G; Office of the Scientific Director, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, MB, Canada.; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
Rosenke K; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.
Frost K; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, MB, Canada.
Tierney K; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, MB, Canada.
Saturday G; Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.
Miao J; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, USA.; Department of Pathology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450066, People's Republic of China.
Westover JB; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, USA.
Gowen BB; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, USA.
Booth S; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, MB, Canada.; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.
Feldmann H; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.
Wang Z; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, USA.
Safronetz D; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, MB, Canada. .; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Jul 23; Vol. 10 (1), pp. 12378. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji:: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Animals, Genetically Modified*/genetics
Animals, Genetically Modified*/metabolism
Animals, Genetically Modified*/virology
Disease Models, Animal*
Hemorrhagic Fever, Crimean*/genetics
Hemorrhagic Fever, Crimean*/metabolism
Hemorrhagic Fever, Crimean*/pathology
Hemorrhagic Fever Virus, Crimean-Congo/*metabolism
STAT2 Transcription Factor/*deficiency
Animals ; Cell Line ; Cricetinae ; Female ; Gene Knockout Techniques ; Hemorrhagic Fever Virus, Crimean-Congo/genetics ; Male ; STAT2 Transcription Factor/metabolism

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Skocz do pozycji: 11.

Tytuł:: Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction.
Autorzy:: Kok F; Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
Rosenblatt M; Institute of Physics, University of Freiburg, Freiburg, Germany.; FDM - Freiburg Center for Data Analysis and Modeling, University of Freiburg, Freiburg, Germany.
Teusel M; Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
Nizharadze T; Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
Gonçalves Magalhães V; Research Group 'Dynamics of Early Viral Infection and the Innate Antiviral Response', Division Virus-Associated Carcinogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Dächert C; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.; Research Group 'Dynamics of Early Viral Infection and the Innate Antiviral Response', Division Virus-Associated Carcinogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Maiwald T; Institute of Physics, University of Freiburg, Freiburg, Germany.
Vlasov A; Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
Wäsch M; Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Tyufekchieva S; Department of General, Visceral and Transplantation Surgery, Ruprecht Karls University Heidelberg, Heidelberg, Germany.
Hoffmann K; Department of General, Visceral and Transplantation Surgery, Ruprecht Karls University Heidelberg, Heidelberg, Germany.
Damm G; Department of Hepatobiliary Surgery and Visceral Transplantation, University of Leipzig, Leipzig, Germany.
Seehofer D; Department of Hepatobiliary Surgery and Visceral Transplantation, University of Leipzig, Leipzig, Germany.
Boettler T; Department of Medicine II, University Hospital Freiburg-Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Binder M; Research Group 'Dynamics of Early Viral Infection and the Innate Antiviral Response', Division Virus-Associated Carcinogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Timmer J; Institute of Physics, University of Freiburg, Freiburg, Germany.; FDM - Freiburg Center for Data Analysis and Modeling, University of Freiburg, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Center for Biological Systems Analysis (ZBSA), University of Freiburg, Freiburg, Germany.
Schilling M; Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Klingmüller U; Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Pokaż więcej
Źródło:: Molecular systems biology [Mol Syst Biol] 2020 Jul; Vol. 16 (7), pp. e8955.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Feedback, Physiological/*drug effects
Hepatocytes/*metabolism
Interferon-alpha/*pharmacology
STAT1 Transcription Factor/*metabolism
STAT2 Transcription Factor/*metabolism
Signal Transduction/*drug effects
Cell Line, Tumor ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/genetics ; Hepatocytes/drug effects ; Humans ; Interferon Regulatory Factor-2/genetics ; Interferon Regulatory Factor-2/metabolism ; Interferon-Stimulated Gene Factor 3, gamma Subunit/genetics ; Interferon-Stimulated Gene Factor 3, gamma Subunit/metabolism ; Models, Theoretical ; RNA, Small Interfering ; STAT1 Transcription Factor/genetics ; STAT2 Transcription Factor/genetics ; Signal Transduction/genetics ; Software ; Suppressor of Cytokine Signaling 1 Protein/genetics ; Suppressor of Cytokine Signaling 1 Protein/metabolism ; Suppressor of Cytokine Signaling 3 Protein/genetics ; Suppressor of Cytokine Signaling 3 Protein/metabolism ; Ubiquitin Thiolesterase/genetics ; Ubiquitin Thiolesterase/metabolism

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Skocz do pozycji: 12.

Tytuł:: HCV and flaviviruses hijack cellular mechanisms for nuclear STAT2 degradation: Up-regulation of PDLIM2 suppresses the innate immune response.
Autorzy:: Joyce MA; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.
Berry-Wynne KM; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.
Dos Santos T; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.
Addison WR; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.
McFarlane N; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.
Hobman T; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.; Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada.
Tyrrell DL; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2019 Aug 02; Vol. 15 (8), pp. e1007949. Date of Electronic Publication: 2019 Aug 02 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Adaptor Proteins, Signal Transducing/*physiology
Flavivirus/*immunology
Flavivirus Infections/*immunology
Hepacivirus/*immunology
Hepatitis C/*immunology
Immunity, Innate/*immunology
LIM Domain Proteins/*physiology
STAT2 Transcription Factor/*metabolism
Animals ; Antiviral Agents/pharmacology ; Flavivirus/drug effects ; Flavivirus Infections/drug therapy ; Flavivirus Infections/virology ; Hepacivirus/drug effects ; Hepatitis C/drug therapy ; Hepatitis C/virology ; Humans ; Immunity, Innate/drug effects ; Interferon-alpha/pharmacology ; LIM Domain Proteins/genetics ; LIM Domain Proteins/metabolism ; Mice ; Mice, Knockout ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; NF-kappa B ; STAT2 Transcription Factor/genetics ; Signal Transduction

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Skocz do pozycji: 13.

Tytuł:: Optimising recruitment in clinical trials for progressive multiple sclerosis: observational analysis from the MS-SMART and MS-STAT2 randomised controlled trials.
Autorzy:: Williams T; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, WC1B 5EH, UK. .
Alexander S; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, WC1B 5EH, UK.
Blackstone J; Comprehensive Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK.
De Angelis F; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, WC1B 5EH, UK.
John N; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, WC1B 5EH, UK.
Doshi A; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, WC1B 5EH, UK.
Beveridge J; MS-STAT2 Trial Patient and Public Involvement Committee, London, UK.
Braisher M; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, WC1B 5EH, UK.
Gray E; Multiple Sclerosis Society (UK), Carriage House, 8 City North Place, London, UK.
Chataway J; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, WC1B 5EH, UK.; National Institute for Health Research, University College London Hospitals, Biomedical Research Centre, London, UK.; Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.; Pokaż więcej
Corporate Authors:: MS-SMART and MS-STAT2 Investigators
Źródło:: Trials [Trials] 2022 Aug 09; Vol. 23 (1), pp. 644. Date of Electronic Publication: 2022 Aug 09.
Typ publikacji:: Journal Article
MeSH Terms:: Multiple Sclerosis*/diagnosis
Multiple Sclerosis*/drug therapy
Multiple Sclerosis, Chronic Progressive*/diagnosis
Multiple Sclerosis, Chronic Progressive*/drug therapy
Neurodegenerative Diseases*
Humans ; London ; Randomized Controlled Trials as Topic ; STAT2 Transcription Factor ; Telephone

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Skocz do pozycji: 14.

Tytuł:: Furosine Induced Apoptosis by the Regulation of STAT1/STAT2 and UBA7/UBE2L6 Genes in HepG2 Cells.
Autorzy:: Li H; Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China. .
Xing L; Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China. lei_.
Zhao N; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China. .
Wang J; Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China. .
Zheng N; Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China. zhengnan_.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2018 May 31; Vol. 19 (6). Date of Electronic Publication: 2018 May 31.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Expression Regulation, Neoplastic*
Apoptosis/*drug effects
Apoptosis/*genetics
Lysine/*analogs & derivatives
STAT1 Transcription Factor/*genetics
STAT2 Transcription Factor/*genetics
Ubiquitin-Conjugating Enzymes/*genetics
Cell Survival/drug effects ; Gene Expression Profiling ; Hep G2 Cells ; Humans ; Lysine/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/metabolism ; Signal Transduction/drug effects ; Ubiquitin-Conjugating Enzymes/metabolism

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Skocz do pozycji: 15.

Tytuł:: STAT and Janus kinase targeting by human herpesvirus 8 interferon regulatory factor in the suppression of type-I interferon signaling.
Autorzy:: Xiang Q; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Yang Z; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Nicholas J; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2022 Jul 01; Vol. 18 (7), pp. e1010676. Date of Electronic Publication: 2022 Jul 01 (Print Publication: 2022).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Herpesvirus 8, Human*/physiology
Humans ; Interferon Regulatory Factors/metabolism ; Interferon Type I/metabolism ; Janus Kinases ; STAT1 Transcription Factor ; STAT2 Transcription Factor/metabolism ; Virus Latency/physiology

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Skocz do pozycji: 16.

Tytuł:: A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma.
Autorzy:: Reed MR; Department of Biochemistry, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.; Department of Neurosurgery, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Lyle AG; Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.; UC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
De Loose A; Department of Neurosurgery, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Maddukuri L; Department of Biochemistry, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Learned K; UC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Beale HC; Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.; UC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Kephart ET; UC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Cheney A; Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.; UC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
van den Bout A; Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.; UC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Lee MP; Department of Neurosurgery, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Hundley KN; Department of Neurosurgery, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Smith AM; KIYATEC Inc., Greenville, SC 29605, USA.
DesRochers TM; KIYATEC Inc., Greenville, SC 29605, USA.
Vibat CRT; KIYATEC Inc., Greenville, SC 29605, USA.
Gokden M; Department of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Salama S; Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.; Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Wardell CP; Department of Biomedical Informatics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Eoff RL; Department of Biochemistry, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Vaske OM; Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Rodriguez A; Department of Neurosurgery, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.; Pokaż więcej
Źródło:: Cells [Cells] 2021 Dec 02; Vol. 10 (12). Date of Electronic Publication: 2021 Dec 02.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Glioblastoma/*genetics
Li-Fraumeni Syndrome/*genetics
STAT1 Transcription Factor/*genetics
STAT2 Transcription Factor/*genetics
Adolescent ; Adult ; Child ; Female ; Gene Expression Regulation, Neoplastic ; Germ-Line Mutation/genetics ; Glioblastoma/complications ; Glioblastoma/pathology ; Humans ; Janus Kinase 1/antagonists & inhibitors ; Janus Kinase 1/genetics ; Janus Kinase 2/antagonists & inhibitors ; Janus Kinase 2/genetics ; Li-Fraumeni Syndrome/complications ; Li-Fraumeni Syndrome/pathology ; Male ; Nitriles/pharmacology ; Organoids/metabolism ; Precision Medicine ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; RNA-Seq ; Transcriptome/genetics ; Young Adult

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Skocz do pozycji: 17.

Tytuł:: STAT2 is involved in the pathogenesis of psoriasis by promoting CXCL11 and CCL5 production by keratinocytes.
Autorzy:: Johansen C; Department of Dermatology, Aarhus University Hospital, Aarhus C, Denmark.
Rittig AH; Department of Dermatology, Aarhus University Hospital, Aarhus C, Denmark.
Mose M; Department of Dermatology, Aarhus University Hospital, Aarhus C, Denmark.
Bertelsen T; Department of Dermatology, Aarhus University Hospital, Aarhus C, Denmark.
Weimar I; Department of Dermatology, Aarhus University Hospital, Aarhus C, Denmark.
Nielsen J; Department of Dermatology, Aarhus University Hospital, Aarhus C, Denmark.
Andersen T; Department of Biomedicine, Aarhus University, Aarhus C, Denmark.
Rasmussen TK; Department of Biomedicine, Aarhus University, Aarhus C, Denmark.
Deleuran B; Department of Biomedicine, Aarhus University, Aarhus C, Denmark.
Iversen L; Department of Dermatology, Aarhus University Hospital, Aarhus C, Denmark.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2017 May 04; Vol. 12 (5), pp. e0176994. Date of Electronic Publication: 2017 May 04 (Print Publication: 2017).
Typ publikacji:: Journal Article
MeSH Terms:: Genetic Predisposition to Disease*
Chemokine CCL5/*biosynthesis
Chemokine CXCL11/*biosynthesis
Keratinocytes/*metabolism
Psoriasis/*genetics
STAT2 Transcription Factor/*physiology
Adult ; Chemokine CCL5/genetics ; Chemokine CXCL11/genetics ; Humans ; Phosphorylation ; Psoriasis/pathology ; STAT2 Transcription Factor/genetics

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Skocz do pozycji: 18.

Tytuł:: Downregulation of SHANK-associated RH domain-interacting protein elevates interleukin-33 expression by stimulating the Janus kinase 2/signal transducer and activator of transcription signalling pathway in HaCaT cells.
Autorzy:: Zhang X; Department of Dermatology, Cosmetology and Venereology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Wang J; Department of Dermatology, Cosmetology and Venereology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Zhu J; Department of Dermatology, Cosmetology and Venereology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Liang Y; Department of Dermatology, Cosmetology and Venereology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.; Pokaż więcej
Źródło:: Clinical and experimental dermatology [Clin Exp Dermatol] 2021 Jul; Vol. 46 (5), pp. 880-887. Date of Electronic Publication: 2021 Mar 23.
Typ publikacji:: Journal Article
MeSH Terms:: Dermatitis, Atopic/*drug therapy
Dermatitis, Atopic/*metabolism
Interleukin-33/*metabolism
STAT2 Transcription Factor/*metabolism
Ubiquitins/*pharmacology
Adolescent ; Adult ; Case-Control Studies ; Child ; Chromatin Immunoprecipitation/methods ; Dermatitis, Atopic/immunology ; Down-Regulation ; Female ; Fluorescent Antibody Technique/methods ; HaCaT Cells/metabolism ; HaCaT Cells/pathology ; Humans ; Immunohistochemistry/methods ; Inflammation/metabolism ; Janus Kinase 2/chemistry ; Janus Kinase 2/metabolism ; Male ; Middle Aged ; Nitriles/therapeutic use ; Pyrazoles/therapeutic use ; Pyrimidines/therapeutic use ; STAT3 Transcription Factor/chemistry ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Th2 Cells/immunology ; Th2 Cells/metabolism ; Ubiquitins/metabolism ; Young Adult

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Skocz do pozycji: 19.

Tytuł:: STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling Pathways.
Autorzy:: Ho J; School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
Pelzel C; School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
Begitt A; School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
Mee M; School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
Elsheikha HM; School of Veterinary Medicine and Science, University of Nottingham, Loughborough, United Kingdom.
Scott DJ; ISIS Spallation Neutron and Muon Source, Rutherford Appleton Laboratory, Didcot, United Kingdom.; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom.; School of Biosciences, University of Nottingham, Nottingham, United Kingdom.
Vinkemeier U; School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.; Pokaż więcej
Źródło:: PLoS biology [PLoS Biol] 2016 Oct 25; Vol. 14 (10), pp. e2000117. Date of Electronic Publication: 2016 Oct 25 (Print Publication: 2016).
Typ publikacji:: Journal Article
MeSH Terms:: Signal Transduction*
STAT1 Transcription Factor/*antagonists & inhibitors
STAT2 Transcription Factor/*physiology
Animals ; Binding Sites ; Cell Nucleus/metabolism ; DNA/metabolism ; Dimerization ; Gene Expression/physiology ; Humans ; Interferon-gamma/metabolism ; Interferon-gamma/physiology ; Phosphorylation ; Protein Binding ; Protein Conformation ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/metabolism

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Skocz do pozycji: 20.

Tytuł:: Inborn Error of STAT2-Dependent IFN-I Immunity in a Patient Presented with Hemophagocytic Lymphohistiocytosis and Multisystem Inflammatory Syndrome in Children
Autorzy:: López-Nevado, MartaAff1, Aff2, IDs10875023014886_cor1
Sevilla, Julián
Almendro-Vázquez, PatriciaAff1, Aff2
Gil-Etayo, Francisco J.Aff1, Aff2
Garcinuño, SaraAff1, Aff2
Serrano-Hernández, AntonioAff1, Aff2
Paz-Artal, EstelaAff1, Aff2, Aff4, Aff5
González-Granado, Luis I.Aff2, Aff4, Aff6
Allende, Luis M.Aff1, Aff2, Aff4, IDs10875023014886_cor9; Pokaż więcej
Źródło:: Journal of Clinical Immunology: International Journal of Inborn Errors of Immunity and Related Diseases. 43(6):1278-1288

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