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Wyszukujesz frazę ""STAT2 Transcription Factor"" wg kryterium: Temat


Tytuł :
Structural basis for STAT2 suppression by flavivirus NS5.
Autorzy :
Wang B; Department of Biochemistry, University of California, Riverside, CA, USA.
Thurmond S; Department of Microbiology and Plant Pathology, University of California, Riverside, CA, USA.; Cell, Molecular and Developmental Biology Graduate Program, University of California, Riverside, CA, USA.
Zhou K; California NanoSystems Institute, University of California, Los Angeles, CA, USA.
Sánchez-Aparicio MT; GlobalHealth and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Fang J; Department of Biochemistry, University of California, Riverside, CA, USA.
Lu J; Department of Biochemistry, University of California, Riverside, CA, USA.
Gao L; Environmental Toxicology Graduate Program, University of California, Riverside, CA, USA.
Ren W; Department of Biochemistry, University of California, Riverside, CA, USA.
Cui Y; California NanoSystems Institute, University of California, Los Angeles, CA, USA.
Veit EC; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hong H; Department of Biochemistry, University of California, Riverside, CA, USA.
Evans MJ; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
O'Leary SE; Department of Biochemistry, University of California, Riverside, CA, USA.
García-Sastre A; GlobalHealth and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zhou ZH; California NanoSystems Institute, University of California, Los Angeles, CA, USA. .; Departement of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, USA. .
Hai R; Department of Microbiology and Plant Pathology, University of California, Riverside, CA, USA. .; Cell, Molecular and Developmental Biology Graduate Program, University of California, Riverside, CA, USA. .
Song J; Department of Biochemistry, University of California, Riverside, CA, USA. .; Environmental Toxicology Graduate Program, University of California, Riverside, CA, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Oct; Vol. 27 (10), pp. 875-885. Date of Electronic Publication: 2020 Aug 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Video-Audio Media
MeSH Terms :
STAT2 Transcription Factor/*chemistry
STAT2 Transcription Factor/*metabolism
Viral Nonstructural Proteins/*chemistry
Cryoelectron Microscopy ; Crystallography, X-Ray ; Cytoplasm/metabolism ; HEK293 Cells ; Host-Pathogen Interactions ; Humans ; Interferon-Stimulated Gene Factor 3, gamma Subunit/metabolism ; Models, Molecular ; Protein Conformation ; STAT2 Transcription Factor/genetics ; Viral Nonstructural Proteins/metabolism ; Zika Virus Infection/virology
Czasopismo naukowe
Tytuł :
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.
Autorzy :
Boudewijns R; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Thibaut HJ; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium. .; GVN, Global Virus Network, Baltimore, MD, USA. .; Translational Platform Virology and Chemotherapy, Leuven, Belgium. .
Kaptein SJF; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Li R; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.
Vergote V; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Seldeslachts L; KU Leuven Department of Imaging and Pathology, Biomedical MRI and MoSAIC, 3000, Leuven, Belgium.
Van Weyenbergh J; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
De Keyzer C; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Bervoets L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Sharma S; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Liesenborghs L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Ma J; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Jansen S; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Van Looveren D; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.; Translational Platform Virology and Chemotherapy, Leuven, Belgium.
Vercruysse T; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.; Translational Platform Virology and Chemotherapy, Leuven, Belgium.
Wang X; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Jochmans D; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Martens E; Immunity and Inflammation Research Group, Immunobiology Unit, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Roose K; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
De Vlieger D; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Schepens B; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Van Buyten T; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Jacobs S; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Liu Y; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.
Martí-Carreras J; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Vanmechelen B; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Wawina-Bokalanga T; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Delang L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Rocha-Pereira J; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Coelmont L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Chiu W; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Leyssen P; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Heylen E; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Schols D; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Wang L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Close L; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Laboratory of Viral Metagenomics, Leuven, Belgium.
Matthijnssens J; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Laboratory of Viral Metagenomics, Leuven, Belgium.
Van Ranst M; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; KU Leuven Department of Laboratory Medicine, University Hospitals Leuven, 3000, Leuven, Belgium.; National Reference Center for Respiratory Pathogens and Enteroviruses, 3000, Leuven, Belgium.; Leuven University Vaccinology Center (LUVAC), 3000, Leuven, Belgium.
Compernolle V; Blood Service, Belgian Red Cross Flanders, Mechelen, Belgium.; Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Schramm G; KU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC, 3000, Leuven, Belgium.; Division of Nuclear Medicine, University Hospitals Leuven, 3000, Leuven, Belgium.
Van Laere K; KU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC, 3000, Leuven, Belgium.; Division of Nuclear Medicine, University Hospitals Leuven, 3000, Leuven, Belgium.
Saelens X; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Callewaert N; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Opdenakker G; Immunity and Inflammation Research Group, Immunobiology Unit, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Maes P; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Weynand B; KU Leuven Department of Imaging and Pathology, Translational Cell and Tissue Research, 3000, Leuven, Belgium.; Division of Translational Cell and Tissue Research, Leuven, Belgium.
Cawthorne C; KU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC, 3000, Leuven, Belgium.
Vande Velde G; KU Leuven Department of Imaging and Pathology, Biomedical MRI and MoSAIC, 3000, Leuven, Belgium.
Wang Z; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.
Neyts J; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium. .; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium. .; GVN, Global Virus Network, Baltimore, MD, USA. .
Dallmeier K; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium. .; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium. .; GVN, Global Virus Network, Baltimore, MD, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 17; Vol. 11 (1), pp. 5838. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Signal Transduction*
Betacoronavirus/*physiology
Coronavirus Infections/*pathology
Coronavirus Infections/*virology
Pneumonia, Viral/*pathology
Pneumonia, Viral/*virology
STAT2 Transcription Factor/*metabolism
Animals ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/metabolism ; Cricetinae ; Immunity, Innate ; Interferon Type I/genetics ; Interferon Type I/metabolism ; Lung/pathology ; Lung/virology ; Mice ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/metabolism ; SARS-CoV-2 ; STAT2 Transcription Factor/genetics ; Virus Replication
Czasopismo naukowe
Tytuł :
Selective Interferon Responses of Intestinal Epithelial Cells Minimize Tumor Necrosis Factor Alpha Cytotoxicity.
Autorzy :
Van Winkle JA; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Constant DA; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Li L; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Nice TJ; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA .
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Źródło :
Journal of virology [J Virol] 2020 Oct 14; Vol. 94 (21). Date of Electronic Publication: 2020 Oct 14 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytokines/*immunology
Intestinal Mucosa/*immunology
Rotavirus Infections/*immunology
STAT1 Transcription Factor/*immunology
STAT2 Transcription Factor/*immunology
Tumor Necrosis Factor-alpha/*toxicity
Animals ; Animals, Newborn ; Cytokines/genetics ; Epithelial Cells/drug effects ; Epithelial Cells/immunology ; Epithelial Cells/virology ; Gene Expression Regulation ; Humans ; Interferon-Stimulated Gene Factor 3, gamma Subunit/genetics ; Interferon-Stimulated Gene Factor 3, gamma Subunit/immunology ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/virology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Organoids/drug effects ; Organoids/immunology ; Organoids/virology ; Response Elements ; Rotavirus/drug effects ; Rotavirus/growth & development ; Rotavirus/pathogenicity ; Rotavirus Infections/genetics ; Rotavirus Infections/pathology ; Rotavirus Infections/virology ; STAT1 Transcription Factor/genetics ; STAT2 Transcription Factor/genetics ; Signal Transduction ; Virus Replication
Czasopismo naukowe
Tytuł :
The Measles Virus V Protein Binding Site to STAT2 Overlaps That of IRF9.
Autorzy :
Nagano Y; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Sugiyama A; Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan.
Kimoto M; Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan.
Wakahara T; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Noguchi Y; Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan.
Jiang X; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Saijo S; Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), Tsukuba, Japan.
Shimizu N; Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), Tsukuba, Japan.
Yabuno N; Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan.
Yao M; Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan.
Gooley PR; Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia.; Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia.
Moseley GW; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Victoria, Australia.
Tadokoro T; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Maenaka K; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.; Global Station for Biosurfaces and Drug Discovery, Center for Life Innovation, Hokkaido University.
Ose T; Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan .; Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan.; PRESTO, Japan Science and Technology Agency, Tokyo, Japan.
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Źródło :
Journal of virology [J Virol] 2020 Aug 17; Vol. 94 (17). Date of Electronic Publication: 2020 Aug 17 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interferon-Stimulated Gene Factor 3, gamma Subunit/*chemistry
Measles virus/*metabolism
Phosphoproteins/*chemistry
STAT2 Transcription Factor/*chemistry
Viral Proteins/*chemistry
Binding Sites ; Gene Expression ; Humans ; Immune Evasion ; Immunity, Innate ; Interferon-Stimulated Gene Factor 3, gamma Subunit/genetics ; Interferon-Stimulated Gene Factor 3, gamma Subunit/metabolism ; Janus Kinases/metabolism ; Measles virus/genetics ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Protein Binding ; Protein Domains ; Protein Interaction Domains and Motifs ; STAT1 Transcription Factor/chemistry ; STAT1 Transcription Factor/genetics ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/genetics ; STAT2 Transcription Factor/metabolism ; Signal Transduction ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Zinc Fingers
Czasopismo naukowe
Tytuł :
Characterization of a novel STAT 2 knock-out hamster model of Crimean-Congo hemorrhagic fever virus pathogenesis.
Autorzy :
Ranadheera C; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, MB, Canada.; Bioforensics Assay Development and Diagnostics, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Valcourt EJ; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, MB, Canada.
Warner BM; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, MB, Canada.; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.
Poliquin G; Office of the Scientific Director, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, MB, Canada.; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
Rosenke K; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.
Frost K; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, MB, Canada.
Tierney K; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, MB, Canada.
Saturday G; Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.
Miao J; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, USA.; Department of Pathology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450066, People's Republic of China.
Westover JB; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, USA.
Gowen BB; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, USA.
Booth S; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, MB, Canada.; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.
Feldmann H; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.
Wang Z; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, USA.
Safronetz D; Zoonotic Diseases and Special Pathogens, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, MB, Canada. .; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 23; Vol. 10 (1), pp. 12378. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Animals, Genetically Modified*/genetics
Animals, Genetically Modified*/metabolism
Animals, Genetically Modified*/virology
Disease Models, Animal*
Hemorrhagic Fever, Crimean*/genetics
Hemorrhagic Fever, Crimean*/metabolism
Hemorrhagic Fever, Crimean*/pathology
Hemorrhagic Fever Virus, Crimean-Congo/*metabolism
STAT2 Transcription Factor/*deficiency
Animals ; Cell Line ; Cricetinae ; Female ; Gene Knockout Techniques ; Hemorrhagic Fever Virus, Crimean-Congo/genetics ; Male ; STAT2 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
STAT2 Limits Host Species Specificity of Human Metapneumovirus.
Autorzy :
Rogers MC; Department of Pediatrics, University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37212, USA.
Miranda-Katz M; Department of Pediatrics, University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.
Zhang Y; Department of Pediatrics, University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.
Oury TD; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Uccellini MB; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Williams JV; Department of Pediatrics, University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.; Institute for Infection, Inflammation, and Immunity in Children (i4Kids), University of Pittsburgh, Pittsburgh, PA 15224, USA.
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Źródło :
Viruses [Viruses] 2020 Jul 04; Vol. 12 (7). Date of Electronic Publication: 2020 Jul 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Metapneumovirus/*physiology
Paramyxoviridae Infections/*immunology
STAT2 Transcription Factor/*immunology
Animals ; Female ; Host Specificity ; Humans ; Immunity, Innate ; Interferons/genetics ; Interferons/immunology ; Male ; Metapneumovirus/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Paramyxoviridae Infections/genetics ; Paramyxoviridae Infections/virology ; STAT2 Transcription Factor/genetics ; Th2 Cells
Czasopismo naukowe
Tytuł :
Homozygous STAT2 gain-of-function mutation by loss of USP18 activity in a patient with type I interferonopathy.
Autorzy :
Gruber C; Department of Microbiology, Icahn School of Medicine at Mt. Sinai, New York, NY.
Martin-Fernandez M; Department of Microbiology, Icahn School of Medicine at Mt. Sinai, New York, NY.
Ailal F; Laboratory of Clinical Immunology, Inflammation and Allergy, Faculty of Medicine and Pharmacy of Casablanca, King Hassan II University, Casablanca, Morocco.; Clinical Immunology Unit, Department of Pediatric Infectious Diseases, Children's Hospital, Centre Hospitalier Universitaire Averroes, Casablanca, Morocco.
Qiu X; Department of Microbiology, Icahn School of Medicine at Mt. Sinai, New York, NY.
Taft J; Department of Microbiology, Icahn School of Medicine at Mt. Sinai, New York, NY.
Altman J; Department of Microbiology, Icahn School of Medicine at Mt. Sinai, New York, NY.
Rosain J; Paris University, Imagine Institute, Paris, France.; Laboratory of Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.
Buta S; Department of Microbiology, Icahn School of Medicine at Mt. Sinai, New York, NY.
Bousfiha A; Laboratory of Clinical Immunology, Inflammation and Allergy, Faculty of Medicine and Pharmacy of Casablanca, King Hassan II University, Casablanca, Morocco.; Clinical Immunology Unit, Department of Pediatric Infectious Diseases, Children's Hospital, Centre Hospitalier Universitaire Averroes, Casablanca, Morocco.
Casanova JL; Paris University, Imagine Institute, Paris, France.; Laboratory of Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.; Howard Hughes Medical Institute, New York, NY.; Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris, Paris, France.
Bustamante J; Paris University, Imagine Institute, Paris, France.; Laboratory of Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.; Center for the Study of Primary Immunodeficiencies, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris, Paris, France.
Bogunovic D; Department of Microbiology, Icahn School of Medicine at Mt. Sinai, New York, NY.; Department of Pediatrics, Icahn School of Medicine at Mt. Sinai, New York, NY.; Precision Immunology Institute, Icahn School of Medicine at Mt. Sinai, New York, NY.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mt. Sinai, New York, NY.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2020 May 04; Vol. 217 (5).
Typ publikacji :
Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gain of Function Mutation/*genetics
Interferon Type I/*metabolism
STAT2 Transcription Factor/*genetics
Ubiquitin Thiolesterase/*deficiency
Amino Acid Sequence ; Base Sequence ; Cell Line ; Female ; Gene Expression Regulation ; Homozygote ; Humans ; Infant, Newborn ; Male ; Pedigree ; Phenotype ; Protein Domains ; STAT2 Transcription Factor/chemistry ; Ubiquitin Thiolesterase/genetics ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
FBXW7-mediated stability regulation of signal transducer and activator of transcription 2 in melanoma formation.
Autorzy :
Lee CJ; College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 14662, Republic of Korea.
An HJ; College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 14662, Republic of Korea.
Kim SM; College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 14662, Republic of Korea.
Yoo SM; College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 14662, Republic of Korea.
Park J; College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 14662, Republic of Korea.
Lee GE; College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 14662, Republic of Korea.
Kim WY; College of Pharmacy, Sookmyung Women's University, Yongsan-gu, Seoul 04310, Republic of Korea.
Kim DJ; Department of Molecular Science, University of Texas Rio Grande Valley, Edinburg, TX 78541.
Kang HC; College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 14662, Republic of Korea.
Lee JY; College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 14662, Republic of Korea.
Lee HS; College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 14662, Republic of Korea.
Cho SJ; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN 55455.
Cho YY; College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 14662, Republic of Korea; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jan 07; Vol. 117 (1), pp. 584-594. Date of Electronic Publication: 2019 Dec 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
F-Box-WD Repeat-Containing Protein 7/*metabolism
Melanoma/*pathology
STAT2 Transcription Factor/*metabolism
Skin Neoplasms/*pathology
Adult ; Aged ; Aged, 80 and over ; Cell Line, Tumor ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Male ; Middle Aged ; Phosphorylation ; Protein Stability ; Proteolysis ; STAT2 Transcription Factor/chemistry ; STAT2 Transcription Factor/genetics ; Serine/metabolism ; Signal Transduction ; Skin/pathology ; Threonine/metabolism ; Tissue Array Analysis ; Ubiquitination ; WD40 Repeats
Czasopismo naukowe
Tytuł :
Atractylodis macrocephalae polysaccharides protect against DSS-induced intestinal injury through a novel lncRNA ITSN1-OT1.
Autorzy :
Zong X; Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, PR China; Key Laboratory of Animal Nutrition and Feed Science in Eastern China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
Xiao X; Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, PR China; Key Laboratory of Animal Nutrition and Feed Science in Eastern China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
Kai L; Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, PR China; Key Laboratory of Animal Nutrition and Feed Science in Eastern China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
Cheng Y; Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, PR China; Key Laboratory of Animal Nutrition and Feed Science in Eastern China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
Fu J; Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, PR China; Key Laboratory of Animal Nutrition and Feed Science in Eastern China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
Xu W; Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
Wang Y; Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, PR China; Key Laboratory of Animal Nutrition and Feed Science in Eastern China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
Zhao K; Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, PR China. Electronic address: .
Jin M; Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, PR China; Key Laboratory of Animal Nutrition and Feed Science in Eastern China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou, PR China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jan 15; Vol. 167, pp. 76-84. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article
MeSH Terms :
Atractylodes/*chemistry
Colitis/*etiology
Dextran Sulfate/*adverse effects
Intestinal Mucosa/*metabolism
Intestinal Mucosa/*pathology
Plant Extracts/*pharmacology
Polysaccharides/*pharmacology
RNA, Long Noncoding/*genetics
Animals ; Apoptosis/drug effects ; Cell Line ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Colitis/drug therapy ; Colitis/pathology ; Computational Biology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Fluorescent Antibody Technique ; Gene Expression Profiling ; Gene Expression Regulation/drug effects ; High-Throughput Nucleotide Sequencing ; In Situ Hybridization, Fluorescence ; Mice ; Plant Extracts/chemistry ; Polysaccharides/chemistry ; Protective Agents/chemistry ; Protective Agents/pharmacology ; STAT2 Transcription Factor/genetics ; STAT2 Transcription Factor/metabolism ; Swine
Czasopismo naukowe
Tytuł :
Impaired upregulation of Stat2 gene restrictive to pancreatic β-cells is responsible for virus-induced diabetes in DBA/2 mice.
Autorzy :
Mine K; Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan; Division of Metabolism and Endocrinology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga, 849-8501, Japan. Electronic address: .
Nagafuchi S; Division of Metabolism and Endocrinology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga, 849-8501, Japan. Electronic address: .
Hatano S; Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Tanaka K; Division of Metabolism and Endocrinology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga, 849-8501, Japan.
Mori H; Division of Metabolism and Endocrinology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga, 849-8501, Japan.
Takahashi H; Division of Metabolism and Endocrinology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga, 849-8501, Japan.
Anzai K; Division of Metabolism and Endocrinology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga, 849-8501, Japan.
Yoshikai Y; Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Jan 22; Vol. 521 (4), pp. 853-860. Date of Electronic Publication: 2019 Nov 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cardiovirus Infections/*complications
Diabetes Mellitus, Type 1/*virology
Insulin-Secreting Cells/*virology
STAT2 Transcription Factor/*genetics
Animals ; Cardiovirus Infections/drug therapy ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/virology ; Diabetes Mellitus, Type 1/genetics ; Encephalomyocarditis virus ; Gene Expression Regulation ; Immunity, Innate/genetics ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/immunology ; Interferon Type I/pharmacology ; Male ; Mice, Inbred C57BL ; Mice, Inbred DBA ; STAT2 Transcription Factor/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Prophylactic and therapeutic HBV vaccination by an HBs-expressing cytomegalovirus vector lacking an interferon antagonist in mice.
Autorzy :
Huang H; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Rückborn M; Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
Le-Trilling VTK; Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
Zhu D; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yang S; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhou W; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yang X; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Feng X; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lu Y; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lu M; Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
Dittmer U; Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
Yang D; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Trilling M; Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
Liu J; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
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Źródło :
European journal of immunology [Eur J Immunol] 2021 Feb; Vol. 51 (2), pp. 393-407. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hepatitis B Surface Antigens/*immunology
Hepatitis B Vaccines/*immunology
Hepatitis B virus/*immunology
Hepatitis B, Chronic/*immunology
Muromegalovirus/*immunology
Animals ; Antiviral Agents/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cells, Cultured ; Female ; Hepatitis B, Chronic/virology ; Immunization/methods ; Interferons/immunology ; Liver/immunology ; Liver/virology ; Male ; Mice ; Mice, Inbred C57BL ; STAT2 Transcription Factor/immunology ; Vaccination/methods ; Virus Replication/immunology
Czasopismo naukowe
Tytuł :
Tick-borne encephalitis virus NS4A ubiquitination antagonizes type I interferon-stimulated STAT1/2 signalling pathway.
Autorzy :
Yang Q; Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou, People's Republic of China.; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People's Republic of China.
You J; College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, People's Republic of China.
Zhou Y; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People's Republic of China.
Wang Y; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People's Republic of China.
Pei R; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People's Republic of China.
Chen X; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People's Republic of China.; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China.
Yang M; Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou, People's Republic of China.
Chen J; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People's Republic of China.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2020 Dec; Vol. 9 (1), pp. 714-726.
Typ publikacji :
Journal Article
MeSH Terms :
Encephalitis Viruses, Tick-Borne/*physiology
Interferon Type I/*antagonists & inhibitors
Viral Nonstructural Proteins/*metabolism
Cell Line ; DEAD Box Protein 58/metabolism ; Encephalitis Viruses, Tick-Borne/metabolism ; Humans ; Interferon Regulatory Factors/antagonists & inhibitors ; Interferon Regulatory Factors/genetics ; Interferon Regulatory Factors/metabolism ; Interferon Type I/metabolism ; Interferon-Induced Helicase, IFIH1/metabolism ; Interferon-Stimulated Gene Factor 3, gamma Subunit/metabolism ; Interferon-beta/genetics ; Interferon-beta/metabolism ; Lysine/metabolism ; Phosphorylation ; Protein Interaction Domains and Motifs ; Protein Multimerization ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/metabolism ; Signal Transduction ; Ubiquitination ; Up-Regulation ; src Homology Domains
Czasopismo naukowe
Tytuł :
A novel variant in STAT2 presenting with hemophagocytic lymphohistiocytosis.
Autorzy :
Alosaimi MF; Division of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Mass; Department of Pediatrics, King Saud University, Riyadh, Saudi Arabia.
Maciag MC; Division of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Mass.
Platt CD; Division of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Mass.
Geha RS; Division of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Mass.
Chou J; Division of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Mass.
Bartnikas LM; Division of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Mass. Electronic address: .
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Źródło :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2019 Aug; Vol. 144 (2), pp. 611-613.e3. Date of Electronic Publication: 2019 May 15.
Typ publikacji :
Case Reports; Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Diseases, Inborn*/genetics
Genetic Diseases, Inborn*/immunology
Genetic Diseases, Inborn*/pathology
Homozygote*
Lymphohistiocytosis, Hemophagocytic*/genetics
Lymphohistiocytosis, Hemophagocytic*/immunology
Lymphohistiocytosis, Hemophagocytic*/pathology
STAT2 Transcription Factor*/genetics
STAT2 Transcription Factor*/immunology
Child, Preschool ; Humans ; Male ; Mutation
Raport
Tytuł :
HCV and flaviviruses hijack cellular mechanisms for nuclear STAT2 degradation: Up-regulation of PDLIM2 suppresses the innate immune response.
Autorzy :
Joyce MA; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.
Berry-Wynne KM; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.
Dos Santos T; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.
Addison WR; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.
McFarlane N; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.
Hobman T; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.; Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada.
Tyrrell DL; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.
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Źródło :
PLoS pathogens [PLoS Pathog] 2019 Aug 02; Vol. 15 (8), pp. e1007949. Date of Electronic Publication: 2019 Aug 02 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*physiology
Flavivirus/*immunology
Flavivirus Infections/*immunology
Hepacivirus/*immunology
Hepatitis C/*immunology
Immunity, Innate/*immunology
LIM Domain Proteins/*physiology
STAT2 Transcription Factor/*metabolism
Animals ; Antiviral Agents/pharmacology ; Flavivirus/drug effects ; Flavivirus Infections/drug therapy ; Flavivirus Infections/virology ; Hepacivirus/drug effects ; Hepatitis C/drug therapy ; Hepatitis C/virology ; Humans ; Immunity, Innate/drug effects ; Interferon-alpha/pharmacology ; LIM Domain Proteins/genetics ; LIM Domain Proteins/metabolism ; Mice ; Mice, Knockout ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; NF-kappa B ; STAT2 Transcription Factor/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription.
Autorzy :
Platanitis E; Max Perutz Labs (MPL), University of Vienna, Vienna, 1030, Austria.
Demiroz D; Max Perutz Labs (MPL), University of Vienna, Vienna, 1030, Austria.
Schneller A; Max Perutz Labs (MPL), University of Vienna, Vienna, 1030, Austria.
Fischer K; Max Perutz Labs (MPL), University of Vienna, Vienna, 1030, Austria.
Capelle C; Max Perutz Labs (MPL), University of Vienna, Vienna, 1030, Austria.
Hartl M; Max Perutz Labs (MPL), University of Vienna, Vienna, 1030, Austria.
Gossenreiter T; Max Perutz Labs (MPL), University of Vienna, Vienna, 1030, Austria.
Müller M; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, 1210, Austria.
Novatchkova M; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna, 1030, Austria.; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, 1030, Austria.
Decker T; Max Perutz Labs (MPL), University of Vienna, Vienna, 1030, Austria. .
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Źródło :
Nature communications [Nat Commun] 2019 Jul 02; Vol. 10 (1), pp. 2921. Date of Electronic Publication: 2019 Jul 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Interferon-Stimulated Gene Factor 3/*metabolism
Interferon-Stimulated Gene Factor 3, gamma Subunit/*metabolism
Interferons/*metabolism
STAT2 Transcription Factor/*metabolism
Animals ; Female ; Humans ; Interferon-Stimulated Gene Factor 3/genetics ; Interferon-Stimulated Gene Factor 3, gamma Subunit/genetics ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Promoter Regions, Genetic ; RAW 264.7 Cells ; STAT1 Transcription Factor/genetics ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/genetics ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism.
Autorzy :
Miorin L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn School of Medicine at Mount Sinai, Global Health and Emerging Pathogens Institute, New York, New York, USA.
Laurent-Rolle M; Section of Infectious Diseases, Yale University, New Haven, Connecticut, USA.
Pisanelli G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn School of Medicine at Mount Sinai, Global Health and Emerging Pathogens Institute, New York, New York, USA.; Department of Veterinary Medicine and Animal Production, University of Naples, Naples, Italy.
Co PH; Department of Biology, Queens College, City University of New York, New York, New York, USA.
Albrecht RA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn School of Medicine at Mount Sinai, Global Health and Emerging Pathogens Institute, New York, New York, USA.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA .; Icahn School of Medicine at Mount Sinai, Global Health and Emerging Pathogens Institute, New York, New York, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Morrison J; Department of Microbiology and Plant Pathology, University of California, Riverside, California, USA .
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Źródło :
Journal of virology [J Virol] 2019 Jun 28; Vol. 93 (14). Date of Electronic Publication: 2019 Jun 28 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Ubiquitination*
Viral Tropism*
STAT2 Transcription Factor/*metabolism
Viral Nonstructural Proteins/*metabolism
Yellow fever virus/*physiology
Animals ; HEK293 Cells ; Humans ; Interferon-alpha/genetics ; Interferon-alpha/metabolism ; Interferon-beta/genetics ; Interferon-beta/metabolism ; Mice ; Mice, Knockout ; STAT2 Transcription Factor/genetics ; Viral Nonstructural Proteins/genetics ; Zika Virus/genetics ; Zika Virus/metabolism
Czasopismo naukowe
Tytuł :
Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1.
Autorzy :
Feng K; From the State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China and.; the University of Chinese Academy of Sciences, Beijing 101408, China.
Deng F; From the State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China and.
Hu Z; From the State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China and.
Wang H; From the State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China and.
Ning YJ; From the State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China and .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 Jun 14; Vol. 294 (24), pp. 9503-9517. Date of Electronic Publication: 2019 Apr 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Bunyaviridae Infections/*immunology
Cell Nucleus/*metabolism
Interferon Type I/*pharmacology
Interferons/*pharmacology
Phlebovirus/*immunology
STAT1 Transcription Factor/*antagonists & inhibitors
STAT2 Transcription Factor/*antagonists & inhibitors
Bunyaviridae Infections/drug therapy ; Bunyaviridae Infections/metabolism ; Bunyaviridae Infections/virology ; Cell Nucleus/drug effects ; Host-Pathogen Interactions ; Humans ; Immune Evasion ; Phlebovirus/drug effects ; Phlebovirus/pathogenicity ; Phosphorylation ; Protein Transport ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling.
Autorzy :
Miorin L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; .; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Kehrer T; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Sanchez-Aparicio MT; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Zhang K; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Cohen P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Patel RS; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Cupic A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Makio T; Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Mei M; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.
Moreno E; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Danziger O; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
White KM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Rathnasinghe R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Uccellini M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Gao S; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Aydillo T; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Mena I; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Yin X; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Martin-Sancho L; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Krogan NJ; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Quantitative Biosciences Institute, University of California San Francisco, CA 94158.; Gladstone Institute of Data Science and Biosciences, J. David Gladstone Institutes, San Francisco, CA 94158.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, CA 94143.
Chanda SK; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Schotsaert M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Wozniak RW; Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Ren Y; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.
Rosenberg BR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Fontoura BMA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; .; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 10; Vol. 117 (45), pp. 28344-28354. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
COVID-19/*metabolism
Interferons/*metabolism
Nuclear Pore/*metabolism
Nuclear Pore Complex Proteins/*metabolism
STAT1 Transcription Factor/*metabolism
STAT2 Transcription Factor/*metabolism
Viral Proteins/*metabolism
Active Transport, Cell Nucleus ; Animals ; Binding Sites ; Chlorocebus aethiops ; HEK293 Cells ; Humans ; Nuclear Matrix-Associated Proteins/chemistry ; Nuclear Matrix-Associated Proteins/metabolism ; Nucleocytoplasmic Transport Proteins/chemistry ; Nucleocytoplasmic Transport Proteins/metabolism ; Protein Binding ; Signal Transduction ; Vero Cells
Czasopismo naukowe
Tytuł :
The Dynamic Interface of Viruses with STATs.
Autorzy :
Harrison AR; Department of Microbiology and Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Moseley GW; Department of Microbiology and Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia .
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Źródło :
Journal of virology [J Virol] 2020 Oct 27; Vol. 94 (22). Date of Electronic Publication: 2020 Oct 27 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
STAT Transcription Factors/*metabolism
Signal Transduction/*physiology
Viruses/*metabolism
Cytokines ; Gene Expression ; Host-Pathogen Interactions ; Immune Evasion ; STAT Transcription Factors/genetics ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/metabolism ; STAT4 Transcription Factor ; STAT6 Transcription Factor ; Viruses/genetics
Czasopismo naukowe
Tytuł :
NS5 Sumoylation Directs Nuclear Responses That Permit Zika Virus To Persistently Infect Human Brain Microvascular Endothelial Cells.
Autorzy :
Conde JN; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.
Schutt WR; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.
Mladinich M; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.; Molecular and Cellular Biology Program, Stony Brook University, Stony Brook, New York, USA.
Sohn SY; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.
Hearing P; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.
Mackow ER; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA .; Molecular and Cellular Biology Program, Stony Brook University, Stony Brook, New York, USA.
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Źródło :
Journal of virology [J Virol] 2020 Sep 15; Vol. 94 (19). Date of Electronic Publication: 2020 Sep 15 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*metabolism
Cell Nucleus/*metabolism
Endothelial Cells/*metabolism
Sumoylation/*physiology
Viral Nonstructural Proteins/*genetics
Viral Nonstructural Proteins/*metabolism
Zika Virus/*genetics
Zika Virus/*metabolism
A549 Cells ; Antiviral Agents/pharmacology ; Binding Sites ; Brain/virology ; Cell Cycle ; Endothelial Cells/virology ; Exoribonucleases/metabolism ; Gene Expression Regulation, Viral ; HEK293 Cells ; HeLa Cells ; Humans ; Immunity, Innate/drug effects ; Models, Molecular ; Mutation ; Promyelocytic Leukemia Protein/metabolism ; STAT2 Transcription Factor/metabolism ; Sequence Alignment ; Sumoylation/drug effects ; Zika Virus/immunology ; Zika Virus Infection/immunology ; Zika Virus Infection/metabolism
Czasopismo naukowe

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