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Tytuł :
SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling.
Autorzy :
Miorin L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; .; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Kehrer T; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Sanchez-Aparicio MT; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Zhang K; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Cohen P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Patel RS; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Cupic A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Makio T; Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Mei M; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.
Moreno E; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Danziger O; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
White KM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Rathnasinghe R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Uccellini M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Gao S; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Aydillo T; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Mena I; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Yin X; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Martin-Sancho L; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Krogan NJ; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Quantitative Biosciences Institute, University of California San Francisco, CA 94158.; Gladstone Institute of Data Science and Biosciences, J. David Gladstone Institutes, San Francisco, CA 94158.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, CA 94143.
Chanda SK; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Schotsaert M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Wozniak RW; Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Ren Y; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.
Rosenberg BR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Fontoura BMA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; .; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 10; Vol. 117 (45), pp. 28344-28354. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
COVID-19/*metabolism
Interferons/*metabolism
Nuclear Pore/*metabolism
Nuclear Pore Complex Proteins/*metabolism
STAT1 Transcription Factor/*metabolism
STAT2 Transcription Factor/*metabolism
Viral Proteins/*metabolism
Active Transport, Cell Nucleus ; Animals ; Binding Sites ; Chlorocebus aethiops ; HEK293 Cells ; Humans ; Nuclear Matrix-Associated Proteins/chemistry ; Nuclear Matrix-Associated Proteins/metabolism ; Nucleocytoplasmic Transport Proteins/chemistry ; Nucleocytoplasmic Transport Proteins/metabolism ; Protein Binding ; Signal Transduction ; Vero Cells
Czasopismo naukowe
Tytuł :
ADAR1 Suppresses Interferon Signaling in Gastric Cancer Cells by MicroRNA-302a-Mediated IRF9/STAT1 Regulation.
Autorzy :
Jiang L; Department of Biomedical Sciences, College of Medicine, Asan Medical Center, University of Ulsan, Seoul 05505, Korea.
Park MJ; Department of Biomedical Sciences, College of Medicine, Asan Medical Center, University of Ulsan, Seoul 05505, Korea.
Cho CJ; Department of Biomedical Sciences, College of Medicine, Asan Medical Center, University of Ulsan, Seoul 05505, Korea.
Lee K; Department of Biomedical Sciences, College of Medicine, Asan Medical Center, University of Ulsan, Seoul 05505, Korea.
Jung MK; Department of Convergence Medicine, College of Medicine, Asan Medical Center, University of Ulsan, Seoul 05505, Korea.
Pack CG; Department of Convergence Medicine, College of Medicine, Asan Medical Center, University of Ulsan, Seoul 05505, Korea.
Myung SJ; Department of Gastroenterology, College of Medicine, Asan Medical Center, University of Ulsan, Seoul 05505, Korea.
Chang S; Department of Biomedical Sciences, College of Medicine, Asan Medical Center, University of Ulsan, Seoul 05505, Korea.; Department of Physiology, College of Medicine, Asan Medical Center, University of Ulsan, Seoul 05505, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Aug 27; Vol. 21 (17). Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Journal Article
MeSH Terms :
Adenosine Deaminase/*genetics
Interferon-Stimulated Gene Factor 3, gamma Subunit/*metabolism
Interferons/*metabolism
MicroRNAs/*genetics
RNA-Binding Proteins/*genetics
STAT2 Transcription Factor/*metabolism
Stomach Neoplasms/*genetics
3' Untranslated Regions ; Adaptor Proteins, Signal Transducing/metabolism ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; HEK293 Cells ; Humans ; Interferon-Stimulated Gene Factor 3, gamma Subunit/genetics ; RNA Editing ; Receptor, Interferon alpha-beta/metabolism ; Signal Transduction ; Stomach Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription.
Autorzy :
Platanitis E; Max Perutz Labs (MPL), University of Vienna, Vienna, 1030, Austria.
Demiroz D; Max Perutz Labs (MPL), University of Vienna, Vienna, 1030, Austria.
Schneller A; Max Perutz Labs (MPL), University of Vienna, Vienna, 1030, Austria.
Fischer K; Max Perutz Labs (MPL), University of Vienna, Vienna, 1030, Austria.
Capelle C; Max Perutz Labs (MPL), University of Vienna, Vienna, 1030, Austria.
Hartl M; Max Perutz Labs (MPL), University of Vienna, Vienna, 1030, Austria.
Gossenreiter T; Max Perutz Labs (MPL), University of Vienna, Vienna, 1030, Austria.
Müller M; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, 1210, Austria.
Novatchkova M; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna, 1030, Austria.; Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, 1030, Austria.
Decker T; Max Perutz Labs (MPL), University of Vienna, Vienna, 1030, Austria. .
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Źródło :
Nature communications [Nat Commun] 2019 Jul 02; Vol. 10 (1), pp. 2921. Date of Electronic Publication: 2019 Jul 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Interferon-Stimulated Gene Factor 3/*metabolism
Interferon-Stimulated Gene Factor 3, gamma Subunit/*metabolism
Interferons/*metabolism
STAT2 Transcription Factor/*metabolism
Animals ; Female ; Humans ; Interferon-Stimulated Gene Factor 3/genetics ; Interferon-Stimulated Gene Factor 3, gamma Subunit/genetics ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Promoter Regions, Genetic ; RAW 264.7 Cells ; STAT1 Transcription Factor/genetics ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/genetics ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1.
Autorzy :
Feng K; From the State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China and.; the University of Chinese Academy of Sciences, Beijing 101408, China.
Deng F; From the State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China and.
Hu Z; From the State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China and.
Wang H; From the State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China and.
Ning YJ; From the State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China and .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 Jun 14; Vol. 294 (24), pp. 9503-9517. Date of Electronic Publication: 2019 Apr 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Bunyaviridae Infections/*immunology
Cell Nucleus/*metabolism
Interferon Type I/*pharmacology
Interferons/*pharmacology
Phlebovirus/*immunology
STAT1 Transcription Factor/*antagonists & inhibitors
STAT2 Transcription Factor/*antagonists & inhibitors
Bunyaviridae Infections/drug therapy ; Bunyaviridae Infections/metabolism ; Bunyaviridae Infections/virology ; Cell Nucleus/drug effects ; Host-Pathogen Interactions ; Humans ; Immune Evasion ; Phlebovirus/drug effects ; Phlebovirus/pathogenicity ; Phosphorylation ; Protein Transport ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus Induces STAT2 Degradation To Inhibit Interferon Signaling.
Autorzy :
Yang L; Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
He J; Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Wang R; Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Zhang X; Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Lin S; Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Ma Z; Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Zhang Y; Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA .
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Źródło :
Journal of virology [J Virol] 2019 Oct 29; Vol. 93 (22). Date of Electronic Publication: 2019 Oct 29 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endoribonucleases/*metabolism
Interferons/*antagonists & inhibitors
Interferons/*metabolism
Porcine respiratory and reproductive syndrome virus/*metabolism
STAT2 Transcription Factor/*antagonists & inhibitors
STAT2 Transcription Factor/*metabolism
Viral Nonstructural Proteins/*metabolism
Amino Acid Sequence ; Animals ; Cell Line ; Endoribonucleases/chemistry ; HEK293 Cells ; HeLa Cells ; Humans ; Immunity, Innate ; Interferon-alpha/pharmacology ; Janus Kinases/antagonists & inhibitors ; Janus Kinases/metabolism ; Models, Molecular ; Phosphorylation ; Porcine Reproductive and Respiratory Syndrome/metabolism ; Porcine Reproductive and Respiratory Syndrome/virology ; Porcine respiratory and reproductive syndrome virus/genetics ; Protein Domains ; Signal Transduction ; Swine ; Viral Nonstructural Proteins/chemistry
Czasopismo naukowe
Tytuł :
Virus-induced autophagic degradation of STAT2 as a mechanism for interferon signaling blockade.
Autorzy :
Avia M; Centro de Investigación en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Valdeolmos, Madrid, Spain.
Rojas JM; Centro de Investigación en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Valdeolmos, Madrid, Spain.
Miorin L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Pascual E; Centro de Investigación en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Valdeolmos, Madrid, Spain.
Van Rijn PA; Department of Virology, Wageningen Bioveterinary Research, Lelystad, The Netherlands.; Department of Biochemistry, Centre for Human Metabolomics, Lelystad, The Netherlands.; North-West University, Potchefstroom, South Africa.
Martín V; Centro de Investigación en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Valdeolmos, Madrid, Spain.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sevilla N; Centro de Investigación en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Valdeolmos, Madrid, Spain.
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Źródło :
EMBO reports [EMBO Rep] 2019 Nov 05; Vol. 20 (11), pp. e48766. Date of Electronic Publication: 2019 Oct 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy*
Host-Pathogen Interactions*
Signal Transduction*
Interferons/*metabolism
STAT2 Transcription Factor/*metabolism
Virus Diseases/*metabolism
Animals ; Bluetongue virus/physiology ; Humans ; Interferon-beta/biosynthesis ; Lysosomes/metabolism ; Models, Biological ; Phosphorylation ; Proteolysis ; Ubiquitination ; Viral Proteins/metabolism ; Virus Diseases/virology
Czasopismo naukowe
Tytuł :
Bclaf1 critically regulates the type I interferon response and is degraded by alphaherpesvirus US3.
Autorzy :
Qin C; State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, China.
Zhang R; State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, China.
Lang Y; State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, China.
Shao A; Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, China.
Xu A; State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, China.
Feng W; Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, China.
Han J; State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, China.
Wang M; State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, China.
He W; State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, China.
Yu C; State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, China.
Tang J; State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, China.
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Źródło :
PLoS pathogens [PLoS Pathog] 2019 Jan 25; Vol. 15 (1), pp. e1007559. Date of Electronic Publication: 2019 Jan 25 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interferons/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Repressor Proteins/*metabolism
Tumor Suppressor Proteins/*metabolism
Viral Proteins/*metabolism
Alphaherpesvirinae/metabolism ; Alphaherpesvirinae/pathogenicity ; Animals ; Antiviral Agents/pharmacology ; Cell Line ; China ; Herpesvirus 1, Human/metabolism ; Herpesvirus 1, Suid/metabolism ; Humans ; Immunity, Innate/drug effects ; Interferon Type I/immunology ; Interferon-Stimulated Gene Factor 3, alpha Subunit/metabolism ; Interferon-alpha/metabolism ; Interferons/immunology ; Mice ; Mice, Inbred BALB C ; Phosphorylation ; Protein-Serine-Threonine Kinases/genetics ; Repressor Proteins/physiology ; Response Elements ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/metabolism ; Signal Transduction/immunology ; Tumor Suppressor Proteins/physiology ; Viral Proteins/genetics ; Virus Diseases/genetics
Czasopismo naukowe
Tytuł :
A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses.
Autorzy :
Michalska A; Department of Human Molecular Genetics, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Poznan, Poland.
Blaszczyk K; Department of Human Molecular Genetics, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Poznan, Poland.
Wesoly J; Laboratory of High Throughput Technologies, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Poznan, Poland.
Bluyssen HAR; Department of Human Molecular Genetics, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Poznan, Poland.
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Źródło :
Frontiers in immunology [Front Immunol] 2018 May 28; Vol. 9, pp. 1135. Date of Electronic Publication: 2018 May 28 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Feedback, Physiological*
Interferon Regulatory Factors/*genetics
Interferon-Stimulated Gene Factor 3/*genetics
Interferons/*metabolism
Animals ; Gene Expression Regulation ; Genome-Wide Association Study ; Germ-Line Mutation ; Humans ; Interferon Regulatory Factors/metabolism ; Interferon-Stimulated Gene Factor 3/metabolism ; Mutation ; Protein Binding ; STAT1 Transcription Factor/chemistry ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/chemistry ; STAT2 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
STAT2-directed pathogen responses.
Autorzy :
Bluyssen H; Department of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland.
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Źródło :
Oncotarget [Oncotarget] 2015 Oct 06; Vol. 6 (30), pp. 28525-6.
Typ publikacji :
Editorial
MeSH Terms :
Immunity, Innate*/genetics
Inflammation Mediators/*metabolism
Interferons/*metabolism
STAT2 Transcription Factor/*metabolism
Animals ; Gene Expression Regulation ; Host-Pathogen Interactions ; Humans ; Inflammation Mediators/immunology ; Interferon-Stimulated Gene Factor 3, gamma Subunit/genetics ; Interferon-Stimulated Gene Factor 3, gamma Subunit/immunology ; Interferon-Stimulated Gene Factor 3, gamma Subunit/metabolism ; Interferons/genetics ; Interferons/immunology ; Phosphorylation ; STAT2 Transcription Factor/genetics ; STAT2 Transcription Factor/immunology ; Signal Transduction
Opinia redakcyjna
Tytuł :
Interferon-Stimulated Genes Are Transcriptionally Repressed by PR in Breast Cancer.
Autorzy :
Walter KR; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas.; Department of Cancer Biology, University of Kansas Medical Center, Kansas City, Kansas.; University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, Kansas.
Goodman ML; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas.; Department of Cancer Biology, University of Kansas Medical Center, Kansas City, Kansas.; University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, Kansas.
Singhal H; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Hall JA; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas.; Department of Cancer Biology, University of Kansas Medical Center, Kansas City, Kansas.; University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, Kansas.
Li T; Department of Molecular Medicine, University of Texas Health San Antonio (UTHSA), San Antonio, Texas.
Holloran SM; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas.; Department of Cancer Biology, University of Kansas Medical Center, Kansas City, Kansas.; University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, Kansas.
Trinca GM; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas.; Department of Cancer Biology, University of Kansas Medical Center, Kansas City, Kansas.; University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, Kansas.
Gibson KA; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas.; Department of Cancer Biology, University of Kansas Medical Center, Kansas City, Kansas.; University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, Kansas.
Jin VX; Department of Molecular Medicine, University of Texas Health San Antonio (UTHSA), San Antonio, Texas.
Greene GL; The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois.
Hagan CR; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas. .; Department of Cancer Biology, University of Kansas Medical Center, Kansas City, Kansas.; University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, Kansas.
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Źródło :
Molecular cancer research : MCR [Mol Cancer Res] 2017 Oct; Vol. 15 (10), pp. 1331-1340. Date of Electronic Publication: 2017 Jul 06.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Regulatory Networks*
Breast Neoplasms/*genetics
Interferons/*pharmacology
Receptors, Progesterone/*metabolism
Transcriptional Activation/*drug effects
Breast Neoplasms/metabolism ; Cell Line, Tumor ; Down-Regulation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Interferon-Stimulated Gene Factor 3, gamma Subunit/metabolism ; Progestins/pharmacology ; STAT2 Transcription Factor/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
IFN-α/IFN-λ responses to respiratory viruses in paediatric asthma.
Autorzy :
Bergauer A; Dept of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.; These authors contributed equally to this paper.
Sopel N; Dept of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.; These authors contributed equally to this paper.
Kroß B; Dept of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.
Vuorinen T; Dept of Virology, University of Turku, Turku, Finland.
Xepapadaki P; Allergy and Clinical Immunology Unit, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
Weiss ST; Translational Genomics Core, Partners Biobank, Partners HealthCare, Personalized Medicine, Cambridge, MA, USA.
Blau A; Translational Genomics Core, Partners Biobank, Partners HealthCare, Personalized Medicine, Cambridge, MA, USA.
Sharma H; Translational Genomics Core, Partners Biobank, Partners HealthCare, Personalized Medicine, Cambridge, MA, USA.
Kraus C; Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.
Springel R; Dept of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.
Rauh M; Children's Hospital, Dept of Paediatrics and Adolescent Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.
Mittler S; Dept of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.
Graser A; Dept of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.
Zimmermann T; Children's Hospital, Dept of Allergy and Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.
Melichar VO; Children's Hospital, Dept of Allergy and Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.
Kiefer A; Children's Hospital, Dept of Allergy and Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.
Kowalski ML; Dept of Immunology, Rheumatology and Allergy, Medical University of Łódź, Łódź, Poland.
Sobanska A; Dept of Immunology, Rheumatology and Allergy, Medical University of Łódź, Łódź, Poland.
Jartti T; Dept of Paediatrics and Adolescent Medicine, Turku University Hospital, Turku, Finland.
Lukkarinen H; Dept of Paediatrics and Adolescent Medicine, Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University Hospital, Turku, Finland.
Papadopoulos NG; Allergy and Clinical Immunology Unit, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.; Division of Infection, Immunity and Respiratory Medicine, The University of Manchester, Manchester, UK.
Finotto S; Dept of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany .
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Źródło :
The European respiratory journal [Eur Respir J] 2017 Feb 02; Vol. 49 (2). Date of Electronic Publication: 2017 Feb 02 (Print Publication: 2017).
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Asthma/*immunology
C-Reactive Protein/*analysis
Interferons/*blood
Leukocytes, Mononuclear/*virology
Picornaviridae Infections/*immunology
Asthma/virology ; Cells, Cultured ; Child, Preschool ; Disease Progression ; Europe ; Female ; Humans ; Interferon Regulatory Factor-1/genetics ; Interferons/immunology ; Male ; Myeloid Differentiation Factor 88/genetics ; Nasopharynx/virology ; Prospective Studies ; RNA, Messenger/analysis ; Rhinovirus ; STAT1 Transcription Factor/genetics ; STAT2 Transcription Factor/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Attack, parry and riposte: molecular fencing between the innate immune system and human herpesviruses.
Autorzy :
Le-Trilling VT; Institute for Virology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Trilling M; Institute for Virology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
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Źródło :
Tissue antigens [Tissue Antigens] 2015 Jul; Vol. 86 (1), pp. 1-13. Date of Electronic Publication: 2015 Jun 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Immune Evasion*
Immunity, Innate*
Herpesviridae/*immunology
Herpesviridae Infections/*virology
Interferons/*antagonists & inhibitors
Viral Proteins/*genetics
Adaptive Immunity ; Gene Expression Regulation ; Herpesviridae/pathogenicity ; Herpesviridae Infections/immunology ; Herpesviridae Infections/pathology ; Humans ; Interferons/genetics ; Interferons/immunology ; STAT1 Transcription Factor/genetics ; STAT1 Transcription Factor/immunology ; STAT2 Transcription Factor/genetics ; STAT2 Transcription Factor/immunology ; Signal Transduction ; Ubiquitins/genetics ; Ubiquitins/immunology ; Viral Proteins/immunology
Czasopismo naukowe
Tytuł :
Response to interferons and antibacterial innate immunity in the absence of tyrosine-phosphorylated STAT1.
Autorzy :
Majoros A; Max F. Perutz Laboratories, University of Vienna, Vienna, Austria.
Platanitis E; Max F. Perutz Laboratories, University of Vienna, Vienna, Austria.
Szappanos D; Max F. Perutz Laboratories, University of Vienna, Vienna, Austria.
Cheon H; Department of Molecular Genetics and Proteomics Core, Lerner Research Institute Cleveland Clinic, Cleveland, OH, USA.
Vogl C; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.
Shukla P; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.
Stark GR; Department of Molecular Genetics and Proteomics Core, Lerner Research Institute Cleveland Clinic, Cleveland, OH, USA.
Sexl V; Department for Biomedical Sciences, Institute of Pharmacology and Toxicology University of Veterinary Medicine Vienna, Vienna, Austria.
Schreiber R; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Schindler C; Departments of Microbiology & Immunology and Medicine, Columbia University, New York, NY, USA.
Müller M; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.
Decker T; Max F. Perutz Laboratories, University of Vienna, Vienna, Austria .
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Źródło :
EMBO reports [EMBO Rep] 2016 Mar; Vol. 17 (3), pp. 367-82. Date of Electronic Publication: 2016 Feb 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
Protein Processing, Post-Translational*
Interferons/*metabolism
Legionnaires' Disease/*immunology
Listeriosis/*immunology
STAT1 Transcription Factor/*deficiency
Animals ; Cell Line ; Cells, Cultured ; Interferon-Stimulated Gene Factor 3, gamma Subunit/metabolism ; Macrophages/immunology ; Mice ; Mice, Inbred C57BL ; Mutation, Missense ; Phosphorylation ; STAT1 Transcription Factor/genetics ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/metabolism ; Second Messenger Systems
Czasopismo naukowe
Tytuł :
Porcine bocavirus NP1 negatively regulates interferon signaling pathway by targeting the DNA-binding domain of IRF9.
Autorzy :
Zhang R; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
Fang L; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China. Electronic address: .
Wang D; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
Cai K; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
Zhang H; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
Xie L; College of Life Science and Technology, Wuhan Institute of Bioengineering, Wuhan 430415, China.
Li Y; College of Life Science and Technology, Wuhan Institute of Bioengineering, Wuhan 430415, China.
Chen H; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
Xiao S; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
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Źródło :
Virology [Virology] 2015 Nov; Vol. 485, pp. 414-21. Date of Electronic Publication: 2015 Sep 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Interaction Domains and Motifs*
Signal Transduction*
Bocavirus/*physiology
Interferon-Stimulated Gene Factor 3, gamma Subunit/*metabolism
Interferons/*metabolism
Viral Nonstructural Proteins/*metabolism
Active Transport, Cell Nucleus ; Animals ; Cell Line ; DNA/metabolism ; Humans ; Interferon-Stimulated Gene Factor 3/metabolism ; Interferon-Stimulated Gene Factor 3, gamma Subunit/chemistry ; Models, Biological ; Phosphorylation ; Protein Binding ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/metabolism ; Swine
Czasopismo naukowe
Tytuł :
Peripheral Blood Cells from Patients with Autoimmune Addison's Disease Poorly Respond to Interferons In Vitro, Despite Elevated Serum Levels of Interferon-Inducible Chemokines.
Autorzy :
Edvardsen K; 1 Department of Clinical Science, University of Bergen , Bergen, Norway .
Bjånesøy T; 2 Department of Biomedicine, University of Bergen , Bergen, Norway .
Hellesen A; 1 Department of Clinical Science, University of Bergen , Bergen, Norway .; 3 Department of Medicine, Haukeland University Hospital , Bergen, Norway .
Breivik L; 1 Department of Clinical Science, University of Bergen , Bergen, Norway .
Bakke M; 2 Department of Biomedicine, University of Bergen , Bergen, Norway .
Husebye ES; 1 Department of Clinical Science, University of Bergen , Bergen, Norway .; 3 Department of Medicine, Haukeland University Hospital , Bergen, Norway .
Bratland E; 1 Department of Clinical Science, University of Bergen , Bergen, Norway .
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Źródło :
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research [J Interferon Cytokine Res] 2015 Oct; Vol. 35 (10), pp. 759-70. Date of Electronic Publication: 2015 May 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Addison Disease/*metabolism
Chemokines/*metabolism
Interferons/*metabolism
Leukocytes, Mononuclear/*metabolism
Addison Disease/blood ; Addison Disease/genetics ; Addison Disease/immunology ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Chemokine CXCL10/blood ; Chemokine CXCL9/blood ; Chemokines/blood ; Comorbidity ; Enzyme-Linked Immunosorbent Assay ; Female ; Genotype ; Humans ; Interferons/pharmacology ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/immunology ; Male ; Middle Aged ; Phosphorylation ; Poly I-C/pharmacology ; Polymorphism, Single Nucleotide ; Protein Tyrosine Phosphatase, Non-Receptor Type 22 ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Identification of amino-acid residues in the V protein of peste des petits ruminants essential for interference and suppression of STAT-mediated interferon signaling.
Autorzy :
Ma X; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Lanzhou 730030, PR China. Electronic address: .
Yang X; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Lanzhou 730030, PR China.
Nian X; Institute of Pathogen Biology and Immunology, Hebei North University, Zhangjiakou 07500, PR China.
Zhang Z; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Lanzhou 730030, PR China.
Dou Y; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Lanzhou 730030, PR China.
Zhang X; Gansu Agricultural University, Lanzhou, PR China.
Luo X; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Lanzhou 730030, PR China.
Su J; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Lanzhou 730030, PR China.
Zhu Q; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Lanzhou 730030, PR China.
Cai X; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Lanzhou 730030, PR China. Electronic address: .
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Źródło :
Virology [Virology] 2015 Sep; Vol. 483, pp. 54-63. Date of Electronic Publication: 2015 May 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Interaction Maps*
Amino Acids/*metabolism
Interferons/*antagonists & inhibitors
Peste-des-petits-ruminants virus/*physiology
STAT1 Transcription Factor/*metabolism
STAT2 Transcription Factor/*metabolism
Viral Proteins/*metabolism
Amino Acids/genetics ; Animals ; Cell Line ; DNA Mutational Analysis ; Humans ; Immune Evasion ; Mutation, Missense ; Protein Binding ; Signal Transduction ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Roles of unphosphorylated ISGF3 in HCV infection and interferon responsiveness.
Autorzy :
Sung PS; Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea;
Cheon H; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195;
Cho CH; Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea;
Hong SH; Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea;
Park DY; Department of Pathology, Pusan National University Hospital and Pusan National University, Busan 602-739, Republic of Korea;
Seo HI; Department of Surgery, Pusan National University Hospital and Pusan National University, Busan 602-739, Republic of Korea;
Park SH; Laboratory of Translational Immunology and Vaccinology, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea;
Yoon SK; Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-040, Republic of Korea.
Stark GR; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195; .
Shin EC; Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Aug 18; Vol. 112 (33), pp. 10443-8. Date of Electronic Publication: 2015 Jul 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endopeptidases/*metabolism
Hepatitis C/*metabolism
Interferon-Stimulated Gene Factor 3, gamma Subunit/*metabolism
Interferons/*immunology
Cell Line ; HEK293 Cells ; Hep G2 Cells ; Hepacivirus ; Hepatitis C/immunology ; Hepatocytes/metabolism ; Humans ; Immunity, Innate ; Lentivirus/metabolism ; Liver/metabolism ; Liver/virology ; Phosphorylation ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/metabolism ; Signal Transduction/drug effects ; Tyrosine/chemistry ; Ubiquitin Thiolesterase
Czasopismo naukowe
Tytuł :
The role of signal transducer and activator of transcription-2 in the interferon response.
Autorzy :
Steen HC; Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
Gamero AM
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Źródło :
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research [J Interferon Cytokine Res] 2012 Mar; Vol. 32 (3), pp. 103-10. Date of Electronic Publication: 2012 Jan 26.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Interferons/*metabolism
STAT2 Transcription Factor/*metabolism
Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Cell Proliferation/drug effects ; Gene Expression Regulation ; Humans ; Immunity, Innate ; Interferons/pharmacology ; Multiprotein Complexes ; Protein Structure, Tertiary ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/chemistry ; STAT2 Transcription Factor/genetics ; Signal Transduction ; Transcription, Genetic/drug effects ; Virus Diseases/immunology ; Viruses/drug effects ; Viruses/immunology
Czasopismo naukowe
Tytuł :
The C proteins of human parainfluenza virus type 1 block IFN signaling by binding and retaining Stat1 in perinuclear aggregates at the late endosome.
Autorzy :
Schomacker H; RNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Hebner RM
Boonyaratanakornkit J
Surman S
Amaro-Carambot E
Collins PL
Schmidt AC
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Źródło :
PloS one [PLoS One] 2012; Vol. 7 (2), pp. e28382. Date of Electronic Publication: 2012 Feb 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Nucleus/*metabolism
Endosomes/*metabolism
Interferons/*metabolism
STAT1 Transcription Factor/*metabolism
STAT2 Transcription Factor/*metabolism
Viral Proteins/*metabolism
Animals ; Blotting, Western ; Chlorocebus aethiops ; Humans ; Immunoprecipitation ; Phosphorylation ; Protein Transport ; STAT1 Transcription Factor/antagonists & inhibitors ; STAT2 Transcription Factor/antagonists & inhibitors ; Signal Transduction ; Vero Cells ; Virus Replication
Czasopismo naukowe
Tytuł :
Homeostatic interferon expression in neurons is sufficient for early control of viral infection.
Autorzy :
Cavanaugh SE; Fox Chase Cancer Center, Program in Immune Cell Development and Host Defense, 333 Cottman Avenue, Philadelphia, PA 19111, United States; Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, United States.
Holmgren AM; Fox Chase Cancer Center, Program in Immune Cell Development and Host Defense, 333 Cottman Avenue, Philadelphia, PA 19111, United States; Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, United States.
Rall GF; Fox Chase Cancer Center, Program in Immune Cell Development and Host Defense, 333 Cottman Avenue, Philadelphia, PA 19111, United States. Electronic address: .
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Źródło :
Journal of neuroimmunology [J Neuroimmunol] 2015 Feb 15; Vol. 279, pp. 11-9. Date of Electronic Publication: 2014 Dec 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Interferons/*metabolism
Measles/*metabolism
Measles virus/*pathogenicity
Neurons/*metabolism
2',5'-Oligoadenylate Synthetase/genetics ; 2',5'-Oligoadenylate Synthetase/metabolism ; Animals ; Cells, Cultured ; Cytokines/genetics ; Cytokines/metabolism ; Disease Models, Animal ; Embryo, Mammalian ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Hippocampus/cytology ; Interferons/genetics ; Interferons/pharmacology ; Measles/pathology ; Membrane Cofactor Protein/genetics ; Mice ; Mice, Transgenic ; Neurons/drug effects ; Neurons/virology ; Phosphopyruvate Hydratase/genetics ; RNA, Messenger/metabolism ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/metabolism ; Time Factors ; Ubiquitins/genetics ; Ubiquitins/metabolism
Czasopismo naukowe

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