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Wyszukujesz frazę ""STAT2 Transcription Factor"" wg kryterium: Temat


Tytuł :
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.
Autorzy :
Boudewijns R; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Thibaut HJ; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium. .; GVN, Global Virus Network, Baltimore, MD, USA. .; Translational Platform Virology and Chemotherapy, Leuven, Belgium. .
Kaptein SJF; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Li R; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.
Vergote V; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Seldeslachts L; KU Leuven Department of Imaging and Pathology, Biomedical MRI and MoSAIC, 3000, Leuven, Belgium.
Van Weyenbergh J; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
De Keyzer C; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Bervoets L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Sharma S; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Liesenborghs L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Ma J; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Jansen S; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Van Looveren D; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.; Translational Platform Virology and Chemotherapy, Leuven, Belgium.
Vercruysse T; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.; Translational Platform Virology and Chemotherapy, Leuven, Belgium.
Wang X; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Jochmans D; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Martens E; Immunity and Inflammation Research Group, Immunobiology Unit, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Roose K; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
De Vlieger D; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Schepens B; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Van Buyten T; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Jacobs S; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Liu Y; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.
Martí-Carreras J; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Vanmechelen B; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Wawina-Bokalanga T; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Delang L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Rocha-Pereira J; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Coelmont L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Chiu W; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Leyssen P; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Heylen E; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Schols D; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Wang L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Close L; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Laboratory of Viral Metagenomics, Leuven, Belgium.
Matthijnssens J; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Laboratory of Viral Metagenomics, Leuven, Belgium.
Van Ranst M; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; KU Leuven Department of Laboratory Medicine, University Hospitals Leuven, 3000, Leuven, Belgium.; National Reference Center for Respiratory Pathogens and Enteroviruses, 3000, Leuven, Belgium.; Leuven University Vaccinology Center (LUVAC), 3000, Leuven, Belgium.
Compernolle V; Blood Service, Belgian Red Cross Flanders, Mechelen, Belgium.; Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Schramm G; KU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC, 3000, Leuven, Belgium.; Division of Nuclear Medicine, University Hospitals Leuven, 3000, Leuven, Belgium.
Van Laere K; KU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC, 3000, Leuven, Belgium.; Division of Nuclear Medicine, University Hospitals Leuven, 3000, Leuven, Belgium.
Saelens X; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Callewaert N; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Opdenakker G; Immunity and Inflammation Research Group, Immunobiology Unit, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Maes P; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Weynand B; KU Leuven Department of Imaging and Pathology, Translational Cell and Tissue Research, 3000, Leuven, Belgium.; Division of Translational Cell and Tissue Research, Leuven, Belgium.
Cawthorne C; KU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC, 3000, Leuven, Belgium.
Vande Velde G; KU Leuven Department of Imaging and Pathology, Biomedical MRI and MoSAIC, 3000, Leuven, Belgium.
Wang Z; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.
Neyts J; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium. .; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium. .; GVN, Global Virus Network, Baltimore, MD, USA. .
Dallmeier K; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium. .; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium. .; GVN, Global Virus Network, Baltimore, MD, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 17; Vol. 11 (1), pp. 5838. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Signal Transduction*
Betacoronavirus/*physiology
Coronavirus Infections/*pathology
Coronavirus Infections/*virology
Pneumonia, Viral/*pathology
Pneumonia, Viral/*virology
STAT2 Transcription Factor/*metabolism
Animals ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/metabolism ; Cricetinae ; Immunity, Innate ; Interferon Type I/genetics ; Interferon Type I/metabolism ; Lung/pathology ; Lung/virology ; Mice ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/metabolism ; SARS-CoV-2 ; STAT2 Transcription Factor/genetics ; Virus Replication
Czasopismo naukowe
Tytuł :
The Dynamic Interface of Viruses with STATs.
Autorzy :
Harrison AR; Department of Microbiology and Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Moseley GW; Department of Microbiology and Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia .
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Źródło :
Journal of virology [J Virol] 2020 Oct 27; Vol. 94 (22). Date of Electronic Publication: 2020 Oct 27 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
STAT Transcription Factors/*metabolism
Signal Transduction/*physiology
Viruses/*metabolism
Cytokines ; Gene Expression ; Host-Pathogen Interactions ; Immune Evasion ; STAT Transcription Factors/genetics ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/metabolism ; STAT4 Transcription Factor ; STAT6 Transcription Factor ; Viruses/genetics
Czasopismo naukowe
Tytuł :
Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.
Autorzy :
Zhang M; The Joint Laboratory of Translational Precision Medicine, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.; The Joint Laboratory of Translational Precision Medicine, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Fu M; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Li M; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Hu H; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Gong S; Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 440106, China; and .
Hu Q; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China; .; Institute for Infection and Immunity, St George's University of London, London SW17 0RE, United Kingdom.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Sep 01; Vol. 205 (5), pp. 1281-1292. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Herpes Genitalis/*immunology
Herpesvirus 2, Human/*immunology
Immediate-Early Proteins/*immunology
Interferon-beta/*immunology
Signal Transduction/*immunology
Ubiquitin-Protein Ligases/*immunology
Viral Proteins/*immunology
Antiviral Agents/immunology ; Cell Line ; Cell Line, Tumor ; HEK293 Cells ; HeLa Cells ; Herpesvirus 1, Human/immunology ; Humans ; Immunity, Innate/immunology ; STAT1 Transcription Factor/immunology ; STAT2 Transcription Factor/immunology ; Ubiquitination/immunology
Czasopismo naukowe
Tytuł :
Porcine circovirus 3 Cap inhibits type I interferon signaling through interaction with STAT2.
Autorzy :
Shen H; College of Animal Science & National Engineering Center for Swine Breeding Industry, South China Agriculture University, Guangzhou, 510642, China; Wen's Foodstuff Group Co. Ltd, Guangdong Enterprise Key Laboratory for Animal Health and Environmental Control, Yunfu, 527439, China.
Liu X; College of Animal Science & National Engineering Center for Swine Breeding Industry, South China Agriculture University, Guangzhou, 510642, China.
Zhang P; College of Animal Science & National Engineering Center for Swine Breeding Industry, South China Agriculture University, Guangzhou, 510642, China.
Wang S; College of Animal Science & National Engineering Center for Swine Breeding Industry, South China Agriculture University, Guangzhou, 510642, China.
Liu Y; College of Animal Science & National Engineering Center for Swine Breeding Industry, South China Agriculture University, Guangzhou, 510642, China.
Zhang L; College of Animal Science & National Engineering Center for Swine Breeding Industry, South China Agriculture University, Guangzhou, 510642, China.
Song C; College of Animal Science & National Engineering Center for Swine Breeding Industry, South China Agriculture University, Guangzhou, 510642, China. Electronic address: .
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Źródło :
Virus research [Virus Res] 2020 Jan 02; Vol. 275, pp. 197804. Date of Electronic Publication: 2019 Nov 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Capsid Proteins/*immunology
Circovirus/*immunology
Interferon Type I/*antagonists & inhibitors
STAT2 Transcription Factor/*immunology
Signal Transduction/*immunology
Capsid Proteins/genetics ; Circovirus/classification ; HEK293 Cells ; Humans ; Immunity, Innate ; Interferon Type I/immunology ; Interferon-beta/antagonists & inhibitors ; Interferon-beta/immunology ; Phosphorylation ; STAT1 Transcription Factor/immunology
Czasopismo naukowe
Tytuł :
A Bayesian gene network reveals insight into the JAK-STAT pathway in systemic lupus erythematosus.
Autorzy :
Li Y; Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Higgs RE; Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Hoffman RW; Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Dow ER; Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Liu X; Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Petri M; Hopkins Lupus Center, John Hopkins University, Baltimore, Maryland, United States of America.
Wallace DJ; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America.
Dörner T; Charité University Hospitals, Berlin, Germany.
Eastwood BJ; Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Miller BB; Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Liu Y; Eli Lilly and Company, Indianapolis, Indiana, United States of America.
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Źródło :
PloS one [PLoS One] 2019 Dec 02; Vol. 14 (12), pp. e0225651. Date of Electronic Publication: 2019 Dec 02 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Genetic*
Gene Regulatory Networks/*immunology
Lupus Erythematosus, Systemic/*genetics
Signal Transduction/*genetics
Algorithms ; Bayes Theorem ; Clinical Trials, Phase III as Topic ; Computer Simulation ; Data Mining ; Datasets as Topic ; Gene Expression Profiling ; Humans ; Janus Kinase 2/immunology ; Janus Kinase 2/metabolism ; Linear Models ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/immunology ; Oligonucleotide Array Sequence Analysis ; Randomized Controlled Trials as Topic ; STAT1 Transcription Factor/immunology ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/immunology ; STAT2 Transcription Factor/metabolism ; Signal Transduction/drug effects ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
The Role of NS5 Protein in Determination of Host Cell Range for Yellow Fever Virus.
Autorzy :
Laurent-Rolle M; Section of Infectious Diseases, Yale University, New Haven, Connecticut.
Morrison J; Department of Microbiology and Plant Pathology, University of California, Riverside, California.
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Źródło :
DNA and cell biology [DNA Cell Biol] 2019 Dec; Vol. 38 (12), pp. 1414-1417. Date of Electronic Publication: 2019 Oct 18.
Typ publikacji :
Journal Article
MeSH Terms :
Host-Pathogen Interactions*
STAT2 Transcription Factor/*metabolism
Signal Transduction/*drug effects
Viral Nonstructural Proteins/*metabolism
Yellow Fever/*metabolism
Yellow fever virus/*isolation & purification
Animals ; Antiviral Agents/pharmacology ; Humans ; Interferon Type I/pharmacology ; Mice ; Ubiquitination ; Yellow Fever/drug therapy ; Yellow Fever/virology ; Yellow fever virus/drug effects
Czasopismo naukowe
Tytuł :
Virus-induced autophagic degradation of STAT2 as a mechanism for interferon signaling blockade.
Autorzy :
Avia M; Centro de Investigación en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Valdeolmos, Madrid, Spain.
Rojas JM; Centro de Investigación en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Valdeolmos, Madrid, Spain.
Miorin L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Pascual E; Centro de Investigación en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Valdeolmos, Madrid, Spain.
Van Rijn PA; Department of Virology, Wageningen Bioveterinary Research, Lelystad, The Netherlands.; Department of Biochemistry, Centre for Human Metabolomics, Lelystad, The Netherlands.; North-West University, Potchefstroom, South Africa.
Martín V; Centro de Investigación en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Valdeolmos, Madrid, Spain.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sevilla N; Centro de Investigación en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Valdeolmos, Madrid, Spain.
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Źródło :
EMBO reports [EMBO Rep] 2019 Nov 05; Vol. 20 (11), pp. e48766. Date of Electronic Publication: 2019 Oct 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy*
Host-Pathogen Interactions*
Signal Transduction*
Interferons/*metabolism
STAT2 Transcription Factor/*metabolism
Virus Diseases/*metabolism
Animals ; Bluetongue virus/physiology ; Humans ; Interferon-beta/biosynthesis ; Lysosomes/metabolism ; Models, Biological ; Phosphorylation ; Proteolysis ; Ubiquitination ; Viral Proteins/metabolism ; Virus Diseases/virology
Czasopismo naukowe
Tytuł :
Toxoplasma gondii effector TgIST blocks type I interferon signaling to promote infection.
Autorzy :
Matta SK; Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63130.
Olias P; Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63130.
Huang Z; Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63130.
Wang Q; Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63130.
Park E; Department of Internal Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63130.
Yokoyama WM; Department of Internal Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63130.
Sibley LD; Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63130; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Aug 27; Vol. 116 (35), pp. 17480-17491. Date of Electronic Publication: 2019 Aug 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Signal Transduction*
Interferon Type I/*metabolism
Protozoan Proteins/*metabolism
Toxoplasma/*physiology
Toxoplasmosis/*metabolism
Toxoplasmosis/*parasitology
Gene Expression Profiling ; Humans ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/metabolism ; Monocytes/immunology ; Monocytes/metabolism ; Protein Binding ; Protein Multimerization ; STAT1 Transcription Factor/chemistry ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/chemistry ; STAT2 Transcription Factor/metabolism ; Toxoplasmosis/immunology
Czasopismo naukowe
Tytuł :
CRISPR/Cas9-based Knockout Strategy Elucidates Components Essential for Type 1 Interferon Signaling in Human HeLa Cells.
Autorzy :
Urin V; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Shemesh M; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Schreiber G; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2019 Aug 09; Vol. 431 (17), pp. 3324-3338. Date of Electronic Publication: 2019 Jun 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
CRISPR-Cas Systems*
Gene Knockout Techniques/*methods
Interferon Type I/*genetics
STAT1 Transcription Factor/*genetics
Signal Transduction/*genetics
Antiviral Agents/pharmacology ; Gene Expression Regulation ; HeLa Cells ; Humans ; Interferon Regulatory Factor-1/genetics ; Interferon-Stimulated Gene Factor 3, gamma Subunit ; Phosphorylation ; Receptor, Interferon alpha-beta/genetics ; STAT2 Transcription Factor ; STAT3 Transcription Factor/genetics ; STAT6 Transcription Factor
Czasopismo naukowe
Tytuł :
Viral Resistance and IFN Signaling in STAT2 Knockout Fish Cells.
Autorzy :
Dehler CE; University of Aberdeen, AB24 2TZ Aberdeen, United Kingdom.
Lester K; Marine Scotland, Marine Laboratory, AB11 9DB Aberdeen, United Kingdom; and.
Della Pelle G; Virologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, Université Paris-Saclay, 78352 Jouy-en-Josas cedex, France.
Jouneau L; Virologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, Université Paris-Saclay, 78352 Jouy-en-Josas cedex, France.
Houel A; Virologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, Université Paris-Saclay, 78352 Jouy-en-Josas cedex, France.
Collins C; Marine Scotland, Marine Laboratory, AB11 9DB Aberdeen, United Kingdom; and.
Dovgan T; University of Aberdeen, AB24 2TZ Aberdeen, United Kingdom.; Marine Scotland, Marine Laboratory, AB11 9DB Aberdeen, United Kingdom; and.
Machat R; Virologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, Université Paris-Saclay, 78352 Jouy-en-Josas cedex, France.
Zou J; University of Aberdeen, AB24 2TZ Aberdeen, United Kingdom.
Boudinot P; Virologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, Université Paris-Saclay, 78352 Jouy-en-Josas cedex, France.
Martin SAM; University of Aberdeen, AB24 2TZ Aberdeen, United Kingdom.
Collet B; Marine Scotland, Marine Laboratory, AB11 9DB Aberdeen, United Kingdom; and .; Virologie et Immunologie Moléculaires, Institut National de la Recherche Agronomique, Université Paris-Saclay, 78352 Jouy-en-Josas cedex, France.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2019 Jul 15; Vol. 203 (2), pp. 465-475. Date of Electronic Publication: 2019 May 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fishes/*metabolism
Interferon Type I/*metabolism
STAT2 Transcription Factor/*metabolism
Signal Transduction/*physiology
Animals ; CRISPR-Cas Systems/physiology ; Cell Line ; Gene Editing/methods ; Virus Diseases/metabolism
Czasopismo naukowe
Tytuł :
Hepatitis B Virus-Induced Imbalance of Inflammatory and Antiviral Signaling by Differential Phosphorylation of STAT1 in Human Monocytes.
Autorzy :
Song H; Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Tan G; Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Yang Y; Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Cui A; Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Li H; Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Li T; Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Wu Z; Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Yang M; Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Lv G; Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Chi X; Institute of Liver Diseases, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Niu J; Institute of Liver Diseases, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Zhu K; Department of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.
Crispe IN; Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.; Department of Pathology, University of Washington, Seattle, WA 98195; and.
Su L; Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.; Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Tu Z; Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China; .; Institute of Liver Diseases, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2019 Apr 15; Vol. 202 (8), pp. 2266-2275. Date of Electronic Publication: 2019 Mar 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
Hepatitis B/*immunology
Hepatitis B virus/*immunology
Monocytes/*immunology
STAT1 Transcription Factor/*immunology
Signal Transduction/*immunology
Hep G2 Cells ; Hepatitis B/pathology ; Humans ; Interleukin-10/immunology ; Monocytes/pathology ; Myeloid Differentiation Factor 88/immunology ; NF-kappa B/immunology ; Phosphorylation/immunology ; STAT2 Transcription Factor/immunology ; Toll-Like Receptor 2/immunology
Czasopismo naukowe
Tytuł :
Structural analysis of the STAT1:STAT2 heterodimer revealed the mechanism of Sendai virus C protein-mediated blockade of type 1 interferon signaling.
Autorzy :
Oda K; From the Departments of Virology and.
Oda T; the Structural Biology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama 230-0045, Japan.
Matoba Y; Microbiology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551 and.
Sato M; the Structural Biology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama 230-0045, Japan.
Irie T; From the Departments of Virology and.
Sakaguchi T; From the Departments of Virology and .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2017 Dec 01; Vol. 292 (48), pp. 19752-19766. Date of Electronic Publication: 2017 Oct 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Interferon Type I/*metabolism
STAT1 Transcription Factor/*metabolism
STAT2 Transcription Factor/*metabolism
Sendai virus/*metabolism
Viral Proteins/*metabolism
Cell Line ; Crystallography, X-Ray ; Dimerization ; Humans ; Phosphorylation ; Protein Conformation ; STAT1 Transcription Factor/chemistry ; STAT2 Transcription Factor/chemistry
Czasopismo naukowe
Tytuł :
Type I interferon-regulated gene expression and signaling in murine mixed glial cells lacking signal transducers and activators of transcription 1 or 2 or interferon regulatory factor 9.
Autorzy :
Li W; From the School of Molecular Bioscience.
Hofer MJ; From the School of Molecular Bioscience.; Bosch Institute, and.; Charles Perkins Centre, University of Sydney, Sydney, New South Wales 2006, Australia.
Songkhunawej P; From the School of Molecular Bioscience.
Jung SR; From the School of Molecular Bioscience.
Hancock D; From the School of Molecular Bioscience.
Denyer G; From the School of Molecular Bioscience.
Campbell IL; From the School of Molecular Bioscience, .; Bosch Institute, and.; Charles Perkins Centre, University of Sydney, Sydney, New South Wales 2006, Australia.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2017 Apr 07; Vol. 292 (14), pp. 5845-5859. Date of Electronic Publication: 2017 Feb 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation/*drug effects
Interferon-Stimulated Gene Factor 3, gamma Subunit/*metabolism
Interferon-alpha/*pharmacology
Neuroglia/*metabolism
STAT1 Transcription Factor/*metabolism
STAT2 Transcription Factor/*metabolism
Signal Transduction/*drug effects
Animals ; Interferon-Stimulated Gene Factor 3/genetics ; Interferon-Stimulated Gene Factor 3/metabolism ; Interferon-Stimulated Gene Factor 3, gamma Subunit/genetics ; Mice ; Mice, Knockout ; Neuroglia/cytology ; STAT1 Transcription Factor/genetics ; STAT2 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling.
Autorzy :
Arimoto KI; Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, USA.
Löchte S; Department of Biology, University of Osnabrück, Osnabrück, Germany.
Stoner SA; Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, USA.
Burkart C; Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, USA.
Zhang Y; Division of Biological Sciences, University of California San Diego, La Jolla, California, USA.
Miyauchi S; Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, USA.
Wilmes S; Department of Biology, University of Osnabrück, Osnabrück, Germany.
Fan JB; Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, USA.
Heinisch JJ; Department of Biology, University of Osnabrück, Osnabrück, Germany.
Li Z; Institut Pasteur, Cytokine Signaling Unit, Inserm, Paris, France.
Yan M; Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, USA.
Pellegrini S; Institut Pasteur, Cytokine Signaling Unit, Inserm, Paris, France.
Colland F; Hybrigenics, impasse Reille, Paris, France.
Piehler J; Department of Biology, University of Osnabrück, Osnabrück, Germany.
Zhang DE; Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, USA.; Division of Biological Sciences, University of California San Diego, La Jolla, California, USA.; Department of Pathology, University of California San Diego, La Jolla, California, USA.
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2017 Mar; Vol. 24 (3), pp. 279-289. Date of Electronic Publication: 2017 Feb 06.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Endopeptidases/*metabolism
Interferon Type I/*metabolism
STAT2 Transcription Factor/*metabolism
Animals ; Cell Line, Tumor ; Feedback, Physiological ; Humans ; Immunoblotting ; Mice ; Mutant Proteins/chemistry ; Mutant Proteins/metabolism ; Protein Binding ; Protein Domains ; Receptor, Interferon alpha-beta/metabolism ; STAT2 Transcription Factor/chemistry ; Two-Hybrid System Techniques ; Ubiquitin Thiolesterase
Czasopismo naukowe
Tytuł :
STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling Pathways.
Autorzy :
Ho J; School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
Pelzel C; School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
Begitt A; School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
Mee M; School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
Elsheikha HM; School of Veterinary Medicine and Science, University of Nottingham, Loughborough, United Kingdom.
Scott DJ; ISIS Spallation Neutron and Muon Source, Rutherford Appleton Laboratory, Didcot, United Kingdom.; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom.; School of Biosciences, University of Nottingham, Nottingham, United Kingdom.
Vinkemeier U; School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
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Źródło :
PLoS biology [PLoS Biol] 2016 Oct 25; Vol. 14 (10), pp. e2000117. Date of Electronic Publication: 2016 Oct 25 (Print Publication: 2016).
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
STAT1 Transcription Factor/*antagonists & inhibitors
STAT2 Transcription Factor/*physiology
Animals ; Binding Sites ; Cell Nucleus/metabolism ; DNA/metabolism ; Dimerization ; Gene Expression/physiology ; Humans ; Interferon-gamma/metabolism ; Interferon-gamma/physiology ; Phosphorylation ; Protein Binding ; Protein Conformation ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
Identification of LncRNA Linc00513 Containing Lupus-Associated Genetic Variants as a Novel Regulator of Interferon Signaling Pathway.
Autorzy :
Xue Z; Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Cui C; Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Liao Z; Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Xia S; Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Zhang P; Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Qin J; Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Guo Q; Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Chen S; Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Fu Q; Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Yin Z; Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.
Ye Z; Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.
Tang Y; Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Shen N; Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
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Źródło :
Frontiers in immunology [Front Immunol] 2018 Dec 18; Vol. 9, pp. 2967. Date of Electronic Publication: 2018 Dec 18 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation/*immunology
Interferon Type I/*metabolism
Lupus Erythematosus, Systemic/*genetics
RNA, Long Noncoding/*metabolism
Signal Transduction/*genetics
Adult ; Female ; Gene Expression Profiling ; Genetic Predisposition to Disease ; Humans ; Interferon Type I/immunology ; Lupus Erythematosus, Systemic/immunology ; Male ; Middle Aged ; Phosphorylation/genetics ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic/genetics ; STAT1 Transcription Factor/metabolism ; STAT2 Transcription Factor/metabolism ; Signal Transduction/immunology ; Young Adult
Czasopismo naukowe
Tytuł :
Suppression of Type I Interferon Signaling by Flavivirus NS5.
Autorzy :
Thurmond S; Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA. .; Graduate Program in Cell, Molecular and Developmental Biology, University of California, Riverside, Riverside, CA 92521, USA. .
Wang B; Department of Biochemistry, University of California, Riverside, Riverside, CA 92521, USA. .
Song J; Department of Biochemistry, University of California, Riverside, Riverside, CA 92521, USA. .
Hai R; Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA 92521, USA. .; Graduate Program in Cell, Molecular and Developmental Biology, University of California, Riverside, Riverside, CA 92521, USA. .
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Źródło :
Viruses [Viruses] 2018 Dec 14; Vol. 10 (12). Date of Electronic Publication: 2018 Dec 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Signal Transduction*
Flavivirus/*immunology
Interferon Type I/*immunology
Viral Nonstructural Proteins/*immunology
Animals ; Chlorocebus aethiops ; Flavivirus/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate ; Interferon Type I/antagonists & inhibitors ; Mice ; STAT2 Transcription Factor/genetics ; Vero Cells
Czasopismo naukowe
Tytuł :
Cilostazol disrupts TLR-4, Akt/GSK-3β/CREB, and IL-6/JAK-2/STAT-3/SOCS-3 crosstalk in a rat model of Huntington's disease.
Autorzy :
El-Abhar H; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Abd El Fattah MA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Wadie W; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
El-Tanbouly DM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
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Źródło :
PloS one [PLoS One] 2018 Sep 27; Vol. 13 (9), pp. e0203837. Date of Electronic Publication: 2018 Sep 27 (Print Publication: 2018).
Typ publikacji :
Journal Article
MeSH Terms :
Cilostazol/*pharmacology
Huntington Disease/*drug therapy
Signal Transduction/*drug effects
Animals ; Apoptosis/drug effects ; CREB-Binding Protein/drug effects ; CREB-Binding Protein/metabolism ; Cilostazol/therapeutic use ; Corpus Striatum/metabolism ; Cyclic AMP Response Element-Binding Protein/metabolism ; Disease Models, Animal ; Glycogen Synthase Kinase 3/metabolism ; Glycogen Synthase Kinase 3 beta/drug effects ; Glycogen Synthase Kinase 3 beta/metabolism ; Huntington Disease/metabolism ; Interleukin-6/metabolism ; Janus Kinase 2/drug effects ; Janus Kinase 2/metabolism ; Male ; Neuroprotective Agents/pharmacology ; Nitro Compounds/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Propionates/pharmacology ; Proto-Oncogene Proteins c-akt/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Wistar ; STAT2 Transcription Factor/metabolism ; STAT3 Transcription Factor/drug effects ; STAT3 Transcription Factor/metabolism ; Suppressor of Cytokine Signaling 3 Protein/drug effects ; Suppressor of Cytokine Signaling 3 Protein/metabolism ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
Nonstructural protein of severe fever with thrombocytopenia syndrome phlebovirus targets STAT2 and not STAT1 to inhibit type I interferon-stimulated JAK-STAT signaling.
Autorzy :
Kitagawa Y; Division of Microbiology and Infectious Diseases, Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.
Sakai M; Division of Microbiology and Infectious Diseases, Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan; Department of Microbiology, Faculty of Bio-Science, Nagahama Institute of Bio-Science and Technology, 1266 Tamura-cho, Nagahama, Shiga, 526-0829, Japan.
Shimojima M; Department of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
Saijo M; Department of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
Itoh M; Department of Microbiology, Faculty of Bio-Science, Nagahama Institute of Bio-Science and Technology, 1266 Tamura-cho, Nagahama, Shiga, 526-0829, Japan.
Gotoh B; Division of Microbiology and Infectious Diseases, Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan. Electronic address: .
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Źródło :
Microbes and infection [Microbes Infect] 2018 Jun - Jul; Vol. 20 (6), pp. 360-368. Date of Electronic Publication: 2018 Jun 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bunyaviridae Infections/*metabolism
Interferon-alpha/*metabolism
Phlebovirus/*metabolism
STAT2 Transcription Factor/*metabolism
Signal Transduction/*physiology
Viral Nonstructural Proteins/*metabolism
Cell Line ; Cytoplasm/metabolism ; Host-Pathogen Interactions ; Humans ; Inclusion Bodies, Viral/metabolism ; Phlebovirus/genetics ; Phosphorylation ; Viral Nonstructural Proteins/genetics
Czasopismo naukowe
Tytuł :
Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission.
Autorzy :
Shahni R; 1 Mitochondrial Research Group, Genetics and Genomic Medicine, UCL Institute of Child Health, Guilford Street, London, UK .
Cale CM; 2 Molecular Immunology Unit, Great Ormond Street Hospital, London, UK.
Anderson G; 3 Histopathology Unit, Great Ormond Street Hospital, London, UK.
Osellame LD; 4 Department of Biochemistry and Molecular Biology, Monash University, Melbourne 3800, Australia.
Hambleton S; 5 Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, UK.
Jacques TS; 3 Histopathology Unit, Great Ormond Street Hospital, London, UK 6 Developmental Neurosciences, UCL Institute of Child Health, London, UK.
Wedatilake Y; 1 Mitochondrial Research Group, Genetics and Genomic Medicine, UCL Institute of Child Health, Guilford Street, London, UK.
Taanman JW; 7 Department of Clinical Neurosciences, UCL Institute of Neurology, Rowland Hill Street, London, UK.
Chan E; 2 Molecular Immunology Unit, Great Ormond Street Hospital, London, UK.
Qasim W; 2 Molecular Immunology Unit, Great Ormond Street Hospital, London, UK.
Plagnol V; 8 UCL Genetics Institute, London, UK.
Chalasani A; 9 Neurometabolic Unit, National Hospital for Neurology and Neurosurgery, London, UK.
Duchen MR; 10 Cell and Developmental Biology, University College London, UK.
Gilmour KC; 2 Molecular Immunology Unit, Great Ormond Street Hospital, London, UK.
Rahman S; 1 Mitochondrial Research Group, Genetics and Genomic Medicine, UCL Institute of Child Health, Guilford Street, London, UK 1 Mitochondrial Research Group, Genetics and Genomic Medicine, UCL Institute of Child Health, Guilford Street, London, UK.
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Źródło :
Brain : a journal of neurology [Brain] 2015 Oct; Vol. 138 (Pt 10), pp. 2834-46. Date of Electronic Publication: 2015 Jun 29.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitochondrial Diseases/*genetics
Mitochondrial Diseases/*metabolism
Mitochondrial Dynamics/*physiology
STAT2 Transcription Factor/*deficiency
Signal Transduction/*genetics
Apoptosis/genetics ; Child, Preschool ; Dynamins ; Electroencephalography ; Family Health ; Female ; Flow Cytometry ; GTP Phosphohydrolases/genetics ; GTP Phosphohydrolases/metabolism ; HEK293 Cells ; Humans ; Infant ; Male ; Microscopy, Electron ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Muscle, Skeletal/pathology ; Muscle, Skeletal/ultrastructure ; Neuroblastoma/pathology ; Phosphorylation ; Protein Processing, Post-Translational ; RNA, Small Nuclear/pharmacology ; STAT2 Transcription Factor/genetics ; Transfection
Czasopismo naukowe

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