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Tytuł :
Porcine Deltacoronavirus nsp5 Cleaves DCP1A To Decrease Its Antiviral Activity.
Autorzy :
Zhu X; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; The Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Chen J; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; The Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Tian L; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; The Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Zhou Y; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; The Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Xu S; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; The Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Long S; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; The Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Wang D; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; The Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Fang L; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China .; The Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Xiao S; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China .; The Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
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Źródło :
Journal of virology [J Virol] 2020 Jul 16; Vol. 94 (15). Date of Electronic Publication: 2020 Jul 16 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Coronavirus/*drug effects
Coronavirus/*metabolism
Cysteine Endopeptidases/*metabolism
Endoribonucleases/*metabolism
Trans-Activators/*metabolism
Viral Nonstructural Proteins/*metabolism
Animals ; Coronavirus 3C Proteases ; Coronavirus Infections/veterinary ; Coronavirus Infections/virology ; Cysteine Endopeptidases/chemistry ; Exoribonucleases/metabolism ; HEK293 Cells ; Host-Pathogen Interactions ; Humans ; Immune Evasion ; Interferons/metabolism ; STAT2 Transcription Factor/metabolism ; Signal Transduction ; Swine ; Swine Diseases/virology
Czasopismo naukowe
Tytuł :
The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment.
Autorzy :
Parrini M; Department of Biomedical Sciences, Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.
Meissl K; Department of Biomedical Sciences, Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.
Ola MJ; Department of Biomedical Sciences, Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.
Lederer T; Department of Biomedical Sciences, Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.
Puga A; Department of Biomedical Sciences, Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.
Wienerroither S; Max F. Perutz Laboratories, University of Vienna, Vienna, Austria.
Kovarik P; Max F. Perutz Laboratories, University of Vienna, Vienna, Austria.
Decker T; Max F. Perutz Laboratories, University of Vienna, Vienna, Austria.
Müller M; Department of Biomedical Sciences, Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.; University Center Biomodels Austria, University of Veterinary Medicine Vienna, Vienna, Austria.
Strobl B; Department of Biomedical Sciences, Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.
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Źródło :
Frontiers in immunology [Front Immunol] 2018 Dec 06; Vol. 9, pp. 2879. Date of Electronic Publication: 2018 Dec 06 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nuclear Proteins/*genetics
Protein Domains/*immunology
RNA Polymerase II/*metabolism
STAT1 Transcription Factor/*metabolism
Trans-Activators/*genetics
Transcriptional Activation/*immunology
Animals ; Cells, Cultured ; GTP-Binding Proteins/genetics ; GTP-Binding Proteins/metabolism ; Histone Code ; Interferon-Stimulated Gene Factor 3, gamma Subunit/genetics ; Interferon-Stimulated Gene Factor 3, gamma Subunit/metabolism ; Macrophages ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nuclear Proteins/metabolism ; Primary Cell Culture ; Promoter Regions, Genetic/genetics ; Protein Isoforms/genetics ; Protein Isoforms/immunology ; Protein Isoforms/metabolism ; STAT1 Transcription Factor/genetics ; STAT1 Transcription Factor/immunology ; STAT2 Transcription Factor/genetics ; STAT2 Transcription Factor/metabolism ; Trans-Activators/metabolism
Czasopismo naukowe
Tytuł :
Differential relocation and stability of PML-body components during productive human cytomegalovirus infection: detailed characterization by live-cell imaging.
Autorzy :
Dimitropoulou P; Department of Virology, Faculty of Medicine, University of Crete, Heraklion 71003, Crete, Greece.
Caswell R
McSharry BP
Greaves RF
Spandidos DA
Wilkinson GW
Sourvinos G
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Źródło :
European journal of cell biology [Eur J Cell Biol] 2010 Oct; Vol. 89 (10), pp. 757-68.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytomegalovirus/*metabolism
Immediate-Early Proteins/*metabolism
Nuclear Proteins/*metabolism
Trans-Activators/*metabolism
Transcription Factors/*metabolism
Tumor Suppressor Proteins/*metabolism
Antigens, Nuclear/genetics ; Antigens, Nuclear/metabolism ; Autoantigens/genetics ; Autoantigens/metabolism ; Chromatin/chemistry ; Chromatin/genetics ; Chromatin/metabolism ; Cytomegalovirus/genetics ; Cytomegalovirus Infections/genetics ; Cytomegalovirus Infections/metabolism ; HeLa Cells ; Humans ; Image Processing, Computer-Assisted ; Immediate-Early Proteins/chemistry ; Immediate-Early Proteins/genetics ; Metaphase/genetics ; Microscopy, Fluorescence ; Microscopy, Video ; Nuclear Proteins/chemistry ; Nuclear Proteins/genetics ; Promyelocytic Leukemia Protein ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; STAT2 Transcription Factor/genetics ; STAT2 Transcription Factor/metabolism ; Trans-Activators/genetics ; Transcription Factors/chemistry ; Transcription Factors/genetics ; Tumor Suppressor Proteins/chemistry ; Tumor Suppressor Proteins/genetics
Czasopismo naukowe
Tytuł :
Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1.
Autorzy :
Precious B; School of Biology, University of St. Andrews, Fife KY16 9TS, United Kingdom.
Childs K
Fitzpatrick-Swallow V
Goodbourn S
Randall RE
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Źródło :
Journal of virology [J Virol] 2005 Nov; Vol. 79 (21), pp. 13434-41.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA-Binding Proteins/*metabolism
Parainfluenza Virus 5/*physiology
Trans-Activators/*metabolism
Viral Structural Proteins/*metabolism
Animals ; Cullin Proteins/metabolism ; Dimerization ; Parainfluenza Virus 5/metabolism ; Protein Binding ; STAT1 Transcription Factor ; STAT2 Transcription Factor ; Signal Transduction ; Virus Replication
Czasopismo naukowe
Tytuł :
Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist.
Autorzy :
Best SM; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA. />Morris KL
Shannon JG
Robertson SJ
Mitzel DN
Park GS
Boer E
Wolfinbarger JB
Bloom ME
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Źródło :
Journal of virology [J Virol] 2005 Oct; Vol. 79 (20), pp. 12828-39.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
DNA-Binding Proteins/*metabolism
Encephalitis Viruses, Tick-Borne/*physiology
Interferons/*antagonists & inhibitors
Methyltransferases/*pharmacology
Protein-Tyrosine Kinases/*metabolism
Trans-Activators/*metabolism
Viral Nonstructural Proteins/*pharmacology
Animals ; Cells, Cultured ; Chlorocebus aethiops ; Dendritic Cells/metabolism ; Dendritic Cells/virology ; Down-Regulation ; Encephalitis Viruses, Tick-Borne/metabolism ; Encephalitis Viruses, Tick-Borne/pathogenicity ; Humans ; Interferon-alpha/antagonists & inhibitors ; Interferon-alpha/metabolism ; Interferon-beta/antagonists & inhibitors ; Interferon-beta/metabolism ; Interferon-gamma/antagonists & inhibitors ; Interferon-gamma/metabolism ; Interferons/metabolism ; Janus Kinase 1 ; Methyltransferases/metabolism ; Phosphorylation ; Receptors, Interferon/metabolism ; STAT1 Transcription Factor ; STAT2 Transcription Factor ; Vero Cells ; Viral Nonstructural Proteins/metabolism ; Virulence ; Virus Replication/physiology
Czasopismo naukowe
Tytuł :
Expression of STAT1 and STAT2 in malignant melanoma does not correlate with response to interferon-alpha adjuvant therapy.
Autorzy :
Lesinski GB; Division of Human Cancer Genetics, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Valentino D
Hade EM
Jones S
Magro C
Chaudhury AR
Walker MJ
Carson WE 3rd
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2005 Sep; Vol. 54 (9), pp. 815-25. Date of Electronic Publication: 2005 Jan 25.
Typ publikacji :
Case Reports; Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Antineoplastic Agents/*therapeutic use
DNA-Binding Proteins/*metabolism
Interferon-alpha/*therapeutic use
Melanoma/*drug therapy
Melanoma/*metabolism
Trans-Activators/*metabolism
Adult ; Aged ; Aged, 80 and over ; Chemotherapy, Adjuvant ; Female ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Lung Neoplasms/secondary ; Lymphatic Metastasis/pathology ; Male ; Melanoma/pathology ; Middle Aged ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/metabolism ; Neoplasm Recurrence, Local/pathology ; STAT1 Transcription Factor ; STAT2 Transcription Factor ; Skin Neoplasms/drug therapy ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology ; Survival Rate
Czasopismo naukowe
Tytuł :
Composition and assembly of STAT-targeting ubiquitin ligase complexes: paramyxovirus V protein carboxyl terminus is an oligomerization domain.
Autorzy :
Ulane CM; Mount Sinai School of Medicine, New York, New York 10029, USA.
Kentsis A
Cruz CD
Parisien JP
Schneider KL
Horvath CM
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Źródło :
Journal of virology [J Virol] 2005 Aug; Vol. 79 (16), pp. 10180-9.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
DNA-Binding Proteins/*metabolism
Trans-Activators/*metabolism
Ubiquitin/*metabolism
Ubiquitin-Protein Ligases/*chemistry
Viral Proteins/*chemistry
Carrier Proteins/physiology ; Cullin Proteins/physiology ; DNA-Binding Proteins/physiology ; Dimerization ; STAT1 Transcription Factor ; STAT2 Transcription Factor ; STAT3 Transcription Factor ; Viral Proteins/physiology
Czasopismo naukowe
Tytuł :
Intracellular domain of the IFNaR2 interferon receptor subunit mediates transcription via Stat2.
Autorzy :
El Fiky A; Department of Pathology, College of Medicine, University of California, Irvine, Irvine, California, USA.
Arch AE
Krolewski JJ
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Źródło :
Journal of cellular physiology [J Cell Physiol] 2005 Aug; Vol. 204 (2), pp. 567-73.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
DNA-Binding Proteins/*physiology
Intracellular Membranes/*metabolism
Membrane Proteins/*physiology
Receptors, Interferon/*physiology
Trans-Activators/*physiology
Transcription, Genetic/*physiology
Cell Line ; DNA-Binding Proteins/metabolism ; Humans ; Janus Kinase 1 ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Protein Structure, Tertiary ; Protein-Tyrosine Kinases/physiology ; Receptor, Interferon alpha-beta ; Receptors, Interferon/genetics ; Receptors, Interferon/metabolism ; STAT2 Transcription Factor ; Trans-Activators/metabolism ; Transcriptional Activation/physiology
Czasopismo naukowe
Tytuł :
Stat1 and Stat2 but not Stat3 arbitrate contradictory growth signals elicited by alpha/beta interferon in T lymphocytes.
Autorzy :
Gimeno R; Department of Pathology and Microbiology, 550 First Ave. MSB548, New York University School of Medicine, New York, New York 10016, USA.
Lee CK
Schindler C
Levy DE
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2005 Jul; Vol. 25 (13), pp. 5456-65.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
DNA-Binding Proteins/*metabolism
Interferon-alpha/*pharmacology
Interferon-beta/*pharmacology
T-Lymphocytes/*metabolism
Trans-Activators/*metabolism
Animals ; Cell Proliferation/drug effects ; Cells, Cultured ; Crosses, Genetic ; DNA-Binding Proteins/genetics ; Flow Cytometry ; Interleukin-2/pharmacology ; Mice ; Mice, Inbred Strains ; Mice, Transgenic ; Proteins/analysis ; STAT1 Transcription Factor ; STAT2 Transcription Factor ; STAT3 Transcription Factor ; Signal Transduction ; Spleen/cytology ; Trans-Activators/genetics
Czasopismo naukowe
Tytuł :
Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness.
Autorzy :
Lo MS; Department of Medicine, Washington University School of Medicine, Campus Box 8052, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
Brazas RM
Holtzman MJ
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Źródło :
Journal of virology [J Virol] 2005 Jul; Vol. 79 (14), pp. 9315-9.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
DNA-Binding Proteins/*antagonists & inhibitors
Interferon-alpha/*antagonists & inhibitors
Interferon-beta/*antagonists & inhibitors
Respiratory Syncytial Virus, Human/*physiology
Trans-Activators/*antagonists & inhibitors
Viral Nonstructural Proteins/*physiology
Cell Line ; DNA-Binding Proteins/analysis ; Humans ; Respiratory Syncytial Virus Infections/immunology ; STAT2 Transcription Factor ; Signal Transduction ; Trans-Activators/analysis
Czasopismo naukowe
Tytuł :
Identification of paramyxovirus V protein residues essential for STAT protein degradation and promotion of virus replication.
Autorzy :
Nishio M; Department of Microbiology, Mie University School of Medicine, Tsu-shi, Mie Prefecture, Japan. />Tsurudome M
Ito M
Garcin D
Kolakofsky D
Ito Y
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Źródło :
Journal of virology [J Virol] 2005 Jul; Vol. 79 (13), pp. 8591-601.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA-Binding Proteins/*metabolism
Paramyxoviridae/*genetics
Trans-Activators/*metabolism
Viral Proteins/*chemistry
Amino Acid Sequence ; Animals ; Binding Sites ; Cell Line ; Cell Line, Tumor ; Chlorocebus aethiops ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; Genes, Reporter ; HeLa Cells ; Humans ; Molecular Sequence Data ; Paramyxoviridae/growth & development ; Plasmids/genetics ; Protein Binding ; STAT2 Transcription Factor ; Sequence Alignment ; Sequence Homology, Amino Acid ; Trans-Activators/chemistry ; Trans-Activators/genetics ; Vero Cells ; Viral Proteins/genetics ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
A cytomegaloviral protein reveals a dual role for STAT2 in IFN-{gamma} signaling and antiviral responses.
Autorzy :
Zimmermann A; Institut für Virologie, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.
Trilling M
Wagner M
Wilborn M
Bubic I
Jonjic S
Koszinowski U
Hengel H
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Źródło :
The Journal of experimental medicine [J Exp Med] 2005 May 16; Vol. 201 (10), pp. 1543-53. Date of Electronic Publication: 2005 May 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carrier Proteins/*immunology
DNA-Binding Proteins/*immunology
Herpesviridae Infections/*immunology
Interferons/*immunology
Muromegalovirus/*immunology
Signal Transduction/*immunology
Trans-Activators/*immunology
Viral Proteins/*immunology
Animals ; Carrier Proteins/genetics ; Cells, Cultured ; Gene Expression Regulation/immunology ; Herpesviridae Infections/genetics ; Mice ; Mice, Knockout ; Muromegalovirus/genetics ; Receptors, Interferon/biosynthesis ; STAT2 Transcription Factor ; Transcription, Genetic/immunology ; Transcriptional Activation/immunology ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Dengue virus inhibits alpha interferon signaling by reducing STAT2 expression.
Autorzy :
Jones M; DDRC, Queen Mary's School of Medicine and Dentistry, Royal Free & University College Medical School, Rowland Hill St., London NW3 2PF, United Kingdom.
Davidson A
Hibbert L
Gruenwald P
Schlaak J
Ball S
Foster GR
Jacobs M
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Źródło :
Journal of virology [J Virol] 2005 May; Vol. 79 (9), pp. 5414-20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA-Binding Proteins/*metabolism
Dengue Virus/*physiology
Interferon-alpha/*physiology
Trans-Activators/*metabolism
Cell Line ; Cell Line, Tumor ; Dengue Virus/pathogenicity ; Down-Regulation ; Humans ; Interferon-alpha/antagonists & inhibitors ; Replicon/physiology ; STAT2 Transcription Factor ; Signal Transduction
Czasopismo naukowe
Tytuł :
JAK/STAT-dependent gene regulation by cytokines.
Autorzy :
Hebenstreit D; Department of Molecular Biology, University of Salzburg, Austria. />Horejs-Hoeck J
Duschl A
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Źródło :
Drug news & perspectives [Drug News Perspect] 2005 May; Vol. 18 (4), pp. 243-9.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cytokines/*pharmacology
DNA-Binding Proteins/*physiology
Gene Expression Regulation/*drug effects
Protein-Tyrosine Kinases/*physiology
Proto-Oncogene Proteins/*physiology
Signal Transduction/*physiology
Trans-Activators/*physiology
Animals ; Humans ; Janus Kinase 1 ; Janus Kinase 2 ; Janus Kinase 3 ; Milk Proteins ; STAT1 Transcription Factor ; STAT2 Transcription Factor ; STAT3 Transcription Factor ; STAT5 Transcription Factor
Czasopismo naukowe
Tytuł :
Hepatitis C virus expression suppresses interferon signaling by degrading STAT1.
Autorzy :
Lin W; Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Choe WH
Hiasa Y
Kamegaya Y
Blackard JT
Schmidt EV
Chung RT
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Źródło :
Gastroenterology [Gastroenterology] 2005 Apr; Vol. 128 (4), pp. 1034-41.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
DNA-Binding Proteins/*metabolism
Hepacivirus/*physiology
Interferons/*antagonists & inhibitors
Interferons/*metabolism
Signal Transduction/*physiology
Trans-Activators/*metabolism
Cell Line, Tumor ; Cell Nucleus/metabolism ; Cytoplasm/metabolism ; DNA-Binding Proteins/genetics ; Hepacivirus/metabolism ; Humans ; Nuclear Proteins/metabolism ; Proteasome Endopeptidase Complex/metabolism ; STAT1 Transcription Factor ; STAT2 Transcription Factor ; Trans-Activators/genetics ; Transfection ; Viral Core Proteins/metabolism ; Viral Proteins/physiology
Czasopismo naukowe
Tytuł :
Functional relevance of the conserved DNA-binding domain of STAT2.
Autorzy :
Brierley MM; Division of Cell & Molecular Biology, Toronto General Research Institute, University Health Network and Department of Immunology, University of Toronto, Toronto, Ontario M5G 2M1, Canada.
Fish EN
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2005 Apr 01; Vol. 280 (13), pp. 13029-36. Date of Electronic Publication: 2005 Jan 24.
Typ publikacji :
Journal Article
MeSH Terms :
DNA-Binding Proteins/*chemistry
Trans-Activators/*chemistry
Cell Nucleus/metabolism ; Cell Proliferation ; Chromatin/metabolism ; Chromatin Immunoprecipitation ; Conserved Sequence ; DNA/chemistry ; DNA/metabolism ; DNA, Complementary/chemistry ; DNA, Complementary/metabolism ; DNA-Binding Proteins/physiology ; Dimerization ; Fibroblasts/metabolism ; Gene Expression Regulation ; Humans ; Immunoblotting ; Interferons/metabolism ; Luciferases/metabolism ; Models, Molecular ; Mutagenesis ; Mutation ; Oligonucleotides/chemistry ; Protein Binding ; Protein Structure, Tertiary ; RNA/metabolism ; STAT2 Transcription Factor ; Time Factors ; Trans-Activators/physiology ; Transcriptional Activation ; Transfection ; Tyrosine/chemistry
Czasopismo naukowe
Tytuł :
Mumps virus V protein antagonizes interferon without the complete degradation of STAT1.
Autorzy :
Kubota T; Department of Virology III, National Institute of Infectious Diseases, Musashi-Murayama, Tokyo 208-0011, Japan. />Yokosawa N
Yokota S
Fujii N
Tashiro M
Kato A
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Źródło :
Journal of virology [J Virol] 2005 Apr; Vol. 79 (7), pp. 4451-9.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA-Binding Proteins/*metabolism
Interferon-beta/*antagonists & inhibitors
Mumps virus/*pathogenicity
Trans-Activators/*metabolism
Viral Proteins/*physiology
Amino Acid Substitution ; Animals ; Cells, Cultured ; Haplorhini ; Janus Kinase 1 ; Mutation ; Phosphorylation ; Protein-Tyrosine Kinases/metabolism ; STAT1 Transcription Factor ; STAT2 Transcription Factor
Czasopismo naukowe
Tytuł :
Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling.
Autorzy :
Hahm B; Division of Virology, Department of Neuropharmacology, Department of Infectology , The Scripps Research Institute, La Jolla, California 92037, USA.
Trifilo MJ
Zuniga EI
Oldstone MB
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Źródło :
Immunity [Immunity] 2005 Feb; Vol. 22 (2), pp. 247-57.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Signal Transduction*
DNA-Binding Proteins/*metabolism
Interferon Type I/*metabolism
Lymphocytic choriomeningitis virus/*physiology
Measles virus/*physiology
Trans-Activators/*metabolism
Animals ; Arenaviridae Infections/immunology ; Arenaviridae Infections/metabolism ; Arenaviridae Infections/virology ; Bone Marrow Cells/cytology ; Bone Marrow Cells/immunology ; Cell Differentiation ; Cells, Cultured ; DNA-Binding Proteins/immunology ; Dendritic Cells/cytology ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Interferon Type I/immunology ; Lymphocytic choriomeningitis virus/immunology ; Measles virus/immunology ; Mice ; Paramyxoviridae Infections/immunology ; Paramyxoviridae Infections/metabolism ; Paramyxoviridae Infections/virology ; STAT1 Transcription Factor ; STAT2 Transcription Factor ; Trans-Activators/immunology
Czasopismo naukowe

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