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Tytuł :
Enhanced anti-tumor effects of the PD-1 blockade combined with a highly absorptive form of curcumin targeting STAT3.
Autorzy :
Hayakawa T; Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.
Yaguchi T; Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.
Kawakami Y; Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.; Department of Immunology, School of Medicine, International University of Health and Welfare, Chiba, Japan.
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Źródło :
Cancer science [Cancer Sci] 2020 Dec; Vol. 111 (12), pp. 4326-4335. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Curcumin/*therapeutic use
Dendritic Cells/*metabolism
Immune Checkpoint Inhibitors/*therapeutic use
Neoplasms/*therapy
STAT3 Transcription Factor/*antagonists & inhibitors
Animals ; Dendritic Cells/immunology ; Drug Therapy, Combination/methods ; Female ; Humans ; Immunotherapy/methods ; Interferon-gamma/metabolism ; Interleukin-6/biosynthesis ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Nude ; NF-kappa B/analysis ; Neoplasms/immunology ; Plant Extracts/therapeutic use ; STAT3 Transcription Factor/analysis ; STAT3 Transcription Factor/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
Effect of the isoflavone corylin from cullen corylifolium on colorectal cancer growth, by targeting the STAT3 signaling pathway.
Autorzy :
Yang L; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Yao Y; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Bai Y; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; The Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, China.
Zheng D; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Zhou F; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Chen L; Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325600, China.
Hu W; The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Xiang Y; The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Zhao H; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; The Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, China.
Liu Z; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Wang L; The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Electronic address: .
Huang X; The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Electronic address: .
Zhao C; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China; The Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Jan; Vol. 80, pp. 153366. Date of Electronic Publication: 2020 Oct 03.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Colorectal Neoplasms/*drug therapy
Flavonoids/*pharmacology
STAT3 Transcription Factor/*metabolism
Animals ; Apoptosis/drug effects ; Caspase 3/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Dose-Response Relationship, Drug ; Fabaceae/chemistry ; Female ; Humans ; Mice, Inbred BALB C ; STAT3 Transcription Factor/genetics ; Signal Transduction/drug effects ; Up-Regulation/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Physapubescin B enhances the sensitivity of gastric cancer cells to trametinib by inhibiting the STAT3 signaling pathway.
Autorzy :
Dai C; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, China.
Shen L; Institute of Basic Theory of TCM, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Jin W; College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310006, China.
Lv B; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, China.
Liu P; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, China.
Wang X; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, China.
Yin Y; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, China.
Fu Y; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, China.
Liang L; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, China.
Ma Z; School of Pharmaceutical Sciences, Zhejiang University, 866 Yu-Hang-Tang Road, Hangzhou 310058, PR China.
Zhang X; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
Wang Y; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, China. Electronic address: .
Xu D; Department of Colorectal Surgery, Wenling Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, Wenling, China. Electronic address: .
Chen Z; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Dec 01; Vol. 408, pp. 115273. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Mitogen-Activated Protein Kinase Kinases/*antagonists & inhibitors
Protein Kinase Inhibitors/*therapeutic use
Pyridones/*therapeutic use
Pyrimidinones/*therapeutic use
STAT3 Transcription Factor/*antagonists & inhibitors
Stomach Neoplasms/*drug therapy
Withanolides/*therapeutic use
Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Humans ; Mice, Nude ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Phosphorylation/drug effects ; Protein Kinase Inhibitors/pharmacology ; Pyridones/pharmacology ; Pyrimidinones/pharmacology ; STAT3 Transcription Factor/metabolism ; Signal Transduction/drug effects ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Withanolides/pharmacology
Czasopismo naukowe
Tytuł :
Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy.
Autorzy :
Gregory JV; Biointerfaces Institute, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.; Chemical Engineering, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.
Kadiyala P; Department of Neurosurgery, University of Michigan Medical School, 1500 E. Medical Center Drive SPC 5338, Ann Arbor, MI, 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI, 48109, USA.
Doherty R; Department of Neurosurgery, University of Michigan Medical School, 1500 E. Medical Center Drive SPC 5338, Ann Arbor, MI, 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI, 48109, USA.
Cadena M; Biointerfaces Institute, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.; Biomedical Engineering, University of Michigan, 2200 Bonisteel Blvd, Ann Arbor, MI, 48109, USA.
Habeel S; Biointerfaces Institute, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.; Biomedical Engineering, University of Michigan, 2200 Bonisteel Blvd, Ann Arbor, MI, 48109, USA.
Ruoslahti E; Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA.; Center for Nanomedicine and Department of Cell, Molecular and Developmental Biology, Building 235, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.
Lowenstein PR; Biointerfaces Institute, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.; Department of Neurosurgery, University of Michigan Medical School, 1500 E. Medical Center Drive SPC 5338, Ann Arbor, MI, 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI, 48109, USA.
Castro MG; Biointerfaces Institute, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA. .; Department of Neurosurgery, University of Michigan Medical School, 1500 E. Medical Center Drive SPC 5338, Ann Arbor, MI, 48109, USA. .; Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI, 48109, USA. .
Lahann J; Biointerfaces Institute, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA. .; Chemical Engineering, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA. .; Biomedical Engineering, University of Michigan, 2200 Bonisteel Blvd, Ann Arbor, MI, 48109, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 10; Vol. 11 (1), pp. 5687. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Delivery Systems*
Nanoparticles*/chemistry
Nanoparticles*/therapeutic use
Glioblastoma/*drug therapy
STAT3 Transcription Factor/*metabolism
Animals ; Blood-Brain Barrier ; Brain Neoplasms/drug therapy ; Cell Line, Tumor ; Gene Silencing ; Humans ; Mice ; RNA, Small Interfering/metabolism ; STAT3 Transcription Factor/antagonists & inhibitors ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
STAT3 isoforms differentially affect ACE2 expression: A potential target for COVID-19 therapy.
Autorzy :
Shamir I; Department of Pediatric Critical Care Medicine, Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.
Abutbul-Amitai M; Department of Pediatric Critical Care Medicine, Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.
Abbas-Egbariya H; Department of Pediatric Critical Care Medicine, Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.
Pasmanik-Chor M; George S. Wise Faculty of Life Science, Bioinformatics Unit, Tel Aviv University, Tel Aviv, Israel.
Paret G; Department of Pediatric Critical Care Medicine, Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.; Sackler Medical School, Tel-Aviv University, Tel-Aviv, Israel.
Nevo-Caspi Y; Department of Pediatric Critical Care Medicine, Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2020 Nov; Vol. 24 (21), pp. 12864-12868. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme 2/*metabolism
STAT3 Transcription Factor/*metabolism
Angiotensin-Converting Enzyme 2/genetics ; Binding Sites ; COVID-19 ; Humans ; MCF-7 Cells ; Promoter Regions, Genetic ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; SARS-CoV-2/drug effects ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
Hyaloid Vasculature as a Major Source of STAT3 (Signal Transducer and Activator of Transcription 3) Myeloid Cells for Pathogenic Retinal Neovascularization in Oxygen-Induced Retinopathy.
Autorzy :
Hombrebueno JR; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).; Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, United Kingdom (J.R.H.).
Lynch A; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).
Byrne EM; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).
Obasanmi G; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).
Kissenpfennig A; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).
Chen M; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).
Xu H; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Dec; Vol. 40 (12), pp. e367-e379. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Oxygen*
Macrophages/*metabolism
Retinal Neovascularization/*metabolism
Retinal Vessels/*metabolism
Retinopathy of Prematurity/*metabolism
STAT3 Transcription Factor/*metabolism
Animals ; Animals, Newborn ; Anthraquinones/pharmacology ; Disease Models, Animal ; Female ; Macrophages/drug effects ; Macrophages/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphorylation ; Retinal Neovascularization/etiology ; Retinal Neovascularization/pathology ; Retinal Neovascularization/prevention & control ; Retinal Vessels/drug effects ; Retinal Vessels/pathology ; Retinopathy of Prematurity/etiology ; Retinopathy of Prematurity/pathology ; Retinopathy of Prematurity/prevention & control ; STAT3 Transcription Factor/antagonists & inhibitors ; Signal Transduction ; Sulfonamides/pharmacology ; Suppressor of Cytokine Signaling 3 Protein/genetics ; Suppressor of Cytokine Signaling 3 Protein/metabolism
Czasopismo naukowe
Tytuł :
2-Thiopyrimidine/chalcone hybrids: design, synthesis, ADMET prediction, and anticancer evaluation as STAT3/STAT5a inhibitors.
Autorzy :
Lamie PF; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Philoppes JN; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 864-879.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Chalcone/*pharmacology
Pyrimidines/*pharmacology
STAT3 Transcription Factor/*antagonists & inhibitors
STAT5 Transcription Factor/*antagonists & inhibitors
Tumor Suppressor Proteins/*antagonists & inhibitors
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line ; Cell Proliferation/drug effects ; Chalcone/chemistry ; Dogs ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Pyrimidines/chemistry ; STAT3 Transcription Factor/metabolism ; STAT5 Transcription Factor/metabolism ; Structure-Activity Relationship ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe
Tytuł :
Febuxostat attenuates testosterone-induced benign prostatic hyperplasia in rats via inhibiting JAK/STAT axis.
Autorzy :
Abo-Youssef AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Afify H; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian-Russian University, Cairo, Egypt.
Azouz AA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Abdel-Rahman HM; Department of Forensic Medicine and Toxicology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abdel-Naim AB; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: .
Allam S; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
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Źródło :
Life sciences [Life Sci] 2020 Nov 01; Vol. 260, pp. 118414. Date of Electronic Publication: 2020 Sep 11.
Typ publikacji :
Journal Article
MeSH Terms :
Febuxostat/*pharmacology
Gene Expression Regulation, Neoplastic/*genetics
Gout Suppressants/*pharmacology
Janus Kinase 1/*metabolism
Prostatic Hyperplasia/*drug therapy
STAT3 Transcription Factor/*metabolism
Testosterone/*toxicity
Androgens/toxicity ; Animals ; Janus Kinase 1/genetics ; Male ; Prostatic Hyperplasia/chemically induced ; Prostatic Hyperplasia/metabolism ; Prostatic Hyperplasia/pathology ; Rats ; Rats, Wistar ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
Human cytomegalovirus protein UL136 activates the IL-6/STAT3 signal through MiR-138 and MiR-34c in gastric cancer cells.
Autorzy :
Shi L; Department of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, China.
Fan B; Department of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, China.
Chen D; Department of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, China.
Guo C; Department of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, China.
Xiang H; Department of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, China.
Nie Y; Department of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, China.
Zhong D; Department of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, China. .
Shi X; Department of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, China. .
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Źródło :
International journal of clinical oncology [Int J Clin Oncol] 2020 Nov; Vol. 25 (11), pp. 1936-1944. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
Interleukin-6/*metabolism
MicroRNAs/*metabolism
STAT3 Transcription Factor/*metabolism
Stomach Neoplasms/*metabolism
Stomach Neoplasms/*virology
Viral Proteins/*metabolism
3' Untranslated Regions ; Animals ; Binding Sites ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cytomegalovirus/genetics ; Cytomegalovirus Infections/metabolism ; Cytomegalovirus Infections/pathology ; Gene Expression Regulation, Neoplastic ; Host-Pathogen Interactions ; Humans ; Interleukin-6/genetics ; Male ; Mice, Inbred BALB C ; MicroRNAs/genetics ; STAT3 Transcription Factor/genetics ; Signal Transduction ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Endothelin-1 stimulates preadipocyte growth via the PKC, STAT3, AMPK, c-JUN, ERK, sphingosine kinase, and sphingomyelinase pathways.
Autorzy :
Siao AC; Department of Life Sciences, National Central University, Taoyuan, Taiwan.
Lin YY; Department of Life Sciences, National Central University, Taoyuan, Taiwan.; Department of Emergency, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan.; National Defense Medical Center, Taipei, Taiwan.
Shih LJ; National Defense Medical Center, Taipei, Taiwan.; Medical Laboratory, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan.
Tsuei YW; Department of Emergency, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan.
Chuu CP; Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Miaoli County, Taiwan.
Kuo YC; Division of Gastroenterology, Landseed Hospital, Taoyuan, Taiwan.
Kao YH; Department of Life Sciences, National Central University, Taoyuan, Taiwan.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2020 Nov 01; Vol. 319 (5), pp. C839-C857. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipocytes/*drug effects
Endothelin-1/*pharmacology
JNK Mitogen-Activated Protein Kinases/*genetics
Protein Kinase C/*genetics
STAT3 Transcription Factor/*genetics
p38 Mitogen-Activated Protein Kinases/*genetics
3T3-L1 Cells ; Adipocytes/cytology ; Adipocytes/metabolism ; Animals ; Butadienes/pharmacology ; Cell Differentiation ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Endothelin Receptor Antagonists/pharmacology ; Extracellular Signal-Regulated MAP Kinases/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Gene Expression Regulation ; Imidazoles/pharmacology ; JNK Mitogen-Activated Protein Kinases/metabolism ; Mice ; Nitriles/pharmacology ; Oligopeptides/pharmacology ; Phosphotransferases (Alcohol Group Acceptor)/genetics ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Piperidines/pharmacology ; Protein Kinase C/metabolism ; Pyridines/pharmacology ; Receptors, Endothelin/genetics ; Receptors, Endothelin/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Sphingomyelin Phosphodiesterase/genetics ; Sphingomyelin Phosphodiesterase/metabolism ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
[Activation of JAK2/STAT3 pathway by CPU0213 alleviates myocardial ischemia-reperfusion and oxidative stress injury in rats].
Autorzy :
Liu Y; First Department of Cardiology, Second Affiliated Hospital of Hebei North University, Zhangjiakou 075100, China.
Li Y; Comprehensive Ward, Second Affiliated Hospital of Hebei North University, Zhangjiakou 075100, China.
Li C; Second Department of Cardiology, Second Affiliated Hospital of Hebei North University, Zhangjiakou 075100, China.
Wang J; First Department of Cardiology, Second Affiliated Hospital of Hebei North University, Zhangjiakou 075100, China.
Xu X; First Department of Cardiology, Second Affiliated Hospital of Hebei North University, Zhangjiakou 075100, China.
Li X; First Department of Cardiology, Second Affiliated Hospital of Hebei North University, Zhangjiakou 075100, China. *Corresponding author, E-mail: .
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Źródło :
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology [Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi] 2020 Nov; Vol. 36 (11), pp. 1009-1015.
Typ publikacji :
Journal Article
MeSH Terms :
Janus Kinase 2*/metabolism
Myocardial Reperfusion Injury*/chemically induced
Myocardial Reperfusion Injury*/drug therapy
Pyrazoles*/pharmacology
Pyrazoles*/therapeutic use
STAT3 Transcription Factor*/metabolism
Animals ; Apoptosis/drug effects ; Cells, Cultured ; Hydrogen Peroxide/toxicity ; Mice ; Oxidative Stress/drug effects ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Leptin, Resistin, and Proprotein Convertase Subtilisin/Kexin Type 9: The Role of STAT3.
Autorzy :
Macchi C; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy. Electronic address: .
Greco MF; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Botta M; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Sperandeo P; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Dongiovanni P; General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Valenti L; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy; Translational Medicine, Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Cicero AFG; Department of Medicine and Surgery Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Borghi C; Department of Medicine and Surgery Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Lupo MG; Department of Pharmaceutical and Pharmacological Sciences, Università degli Studi di Padova, Padova, Italy.
Romeo S; Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden; Clinical Nutrition Unit, Department of Medical and Surgical Science, Magna Graecia University, Catanzaro, Italy; Department of Cardiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Corsini A; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy; IRCCS MultiMedica, Sesto S. Giovanni, Milan, Italy.
Magni P; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy; IRCCS MultiMedica, Sesto S. Giovanni, Milan, Italy.
Ferri N; Department of Pharmaceutical and Pharmacological Sciences, Università degli Studi di Padova, Padova, Italy.
Ruscica M; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy. Electronic address: .
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Źródło :
The American journal of pathology [Am J Pathol] 2020 Nov; Vol. 190 (11), pp. 2226-2236. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Up-Regulation*
Leptin/*metabolism
Proprotein Convertase 9/*biosynthesis
Resistin/*metabolism
STAT3 Transcription Factor/*metabolism
Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Hep G2 Cells ; Humans ; Leptin/genetics ; Obesity/genetics ; Obesity/metabolism ; Obesity/pathology ; Proprotein Convertase 9/genetics ; Resistin/genetics ; Response Elements ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
Interleukin-23 drives expansion of Thelper 17 cells through epigenetic regulation by signal transducer and activators of transcription 3 in lupus patients.
Autorzy :
Lee S; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Nakayamada S; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Kubo S; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Yamagata K; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Yoshinari H; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Tanaka Y; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
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Źródło :
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2020 Oct 01; Vol. 59 (10), pp. 3058-3069.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-23/*pharmacology
Lupus Erythematosus, Systemic/*blood
STAT3 Transcription Factor/*blood
Th17 Cells/*drug effects
Azetidines/pharmacology ; CD4-Positive T-Lymphocytes/drug effects ; Cell Proliferation/drug effects ; Chromatin Immunoprecipitation/methods ; Epigenesis, Genetic ; Flow Cytometry ; Gene Expression ; Humans ; Interleukin-12/pharmacology ; Interleukins/pharmacology ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Nuclear Receptor Subfamily 1, Group F, Member 3/genetics ; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism ; Phosphorylation ; Purines/pharmacology ; Pyrazoles/pharmacology ; Real-Time Polymerase Chain Reaction/methods ; STAT3 Transcription Factor/drug effects ; STAT3 Transcription Factor/metabolism ; STAT4 Transcription Factor/metabolism ; Signal Transduction ; Sulfonamides/pharmacology ; Th17 Cells/metabolism
Czasopismo naukowe
Tytuł :
Effect of NMO-IgG on the interleukin-6 cascade in astrocytes via activation of the JAK/STAT3 signaling pathway.
Autorzy :
Du L; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China.
Chang H; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China.
Xu W; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China.
Wei Y; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China.
Wang Y; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China.
Yin L; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China. Electronic address: .
Zhang X; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Oct 01; Vol. 258, pp. 118217. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article
MeSH Terms :
Astrocytes/*metabolism
Immunoglobulin G/*blood
Interleukin-6/*metabolism
Janus Kinases/*metabolism
Neuromyelitis Optica/*blood
STAT3 Transcription Factor/*metabolism
Adult ; Aged ; Animals ; Astrocytes/drug effects ; Autoantibodies/blood ; Autoantibodies/pharmacology ; Cells, Cultured ; Female ; Humans ; Immunoglobulin G/pharmacology ; Interleukin-6/agonists ; Male ; Middle Aged ; Rats ; Rats, Wistar ; STAT3 Transcription Factor/agonists ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Young Adult
Czasopismo naukowe
Tytuł :
Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains.
Autorzy :
La Sala G; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL), Station 19, 1015, Lausanne, Switzerland.
Michiels C; Experimental Medicine Unit, De Duve Institute, Université catholique de Louvain, 1200, Brussels, Belgium.
Kükenshöner T; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL), Station 19, 1015, Lausanne, Switzerland.
Brandstoetter T; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Maurer B; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Koide A; Department of Medicine, New York University School of Medicine, 522 1st Avenue, New York, 10016, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, 522 1st Avenue, New York, 10016, NY, USA.
Lau K; Protein Crystallography Core Facility, School of Life Sciences, École polytechnique fédérale de Lausanne, Station 19, 1015, Lausanne, Switzerland.
Pojer F; Protein Crystallography Core Facility, School of Life Sciences, École polytechnique fédérale de Lausanne, Station 19, 1015, Lausanne, Switzerland.
Koide S; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, 522 1st Avenue, New York, 10016, NY, USA.; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, 522 1st Avenue, New York, 10016, NY, USA.
Sexl V; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Dumoutier L; Experimental Medicine Unit, De Duve Institute, Université catholique de Louvain, 1200, Brussels, Belgium.
Hantschel O; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL), Station 19, 1015, Lausanne, Switzerland. .; Faculty of Medicine, Institute of Physiological Chemistry, Philipps-University of Marburg, Karl-von-Frisch-Straße 1, 35032, Marburg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 17; Vol. 11 (1), pp. 4115. Date of Electronic Publication: 2020 Aug 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies/*metabolism
STAT3 Transcription Factor/*metabolism
A549 Cells ; Antibodies/genetics ; Blotting, Western ; Calorimetry ; Crystallography, X-Ray ; Flow Cytometry ; Fluorescence Polarization ; Fluorescent Antibody Technique ; Humans ; Mass Spectrometry ; Protein Binding ; Protein Domains/immunology ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/immunology ; Signal Transduction/genetics ; Signal Transduction/physiology ; Synthetic Biology
Czasopismo naukowe
Tytuł :
Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia.
Autorzy :
Shukla SK; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
Markov SD; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
Attri KS; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
Vernucci E; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
King RJ; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
Dasgupta A; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
Grandgenett PM; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
Hollingsworth MA; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
Singh PK; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
Yu F; Department of Biostatistics, University of Nebraska Medical Center, Omaha, NE, USA.
Mehla K; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Aug 01; Vol. 484, pp. 29-39. Date of Electronic Publication: 2020 Apr 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cachexia/*immunology
Macrophages/*immunology
Muscle, Skeletal/*immunology
Pancreatic Neoplasms/*immunology
STAT3 Transcription Factor/*immunology
Signal Transduction/*immunology
Animals ; Cachexia/metabolism ; Cell Line ; Cell Line, Tumor ; Cells, Cultured ; Culture Media, Conditioned/pharmacology ; Cytokines/blood ; Cytokines/immunology ; Cytokines/metabolism ; Humans ; Macrophages/metabolism ; Mice, Inbred C57BL ; Muscle Fibers, Skeletal/drug effects ; Muscle Fibers, Skeletal/immunology ; Muscle Fibers, Skeletal/metabolism ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Pancreatic Neoplasms/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction/drug effects ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
Inhibition of STAT3 phosphorylation attenuates impairments in learning and memory in 5XFAD mice, an animal model of Alzheimer's disease.
Autorzy :
Choi M; Department of Pharmacology and Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
Kim H; Department of Pharmacology and Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
Yang EJ; Department of Pharmacology and Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
Kim HS; Department of Pharmacology and Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea; Seoul National University Bundang Hospital, Seoul National University College of Medicine, Sungnam, Republic of Korea; Dementia Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: .
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Źródło :
Journal of pharmacological sciences [J Pharmacol Sci] 2020 Aug; Vol. 143 (4), pp. 290-299. Date of Electronic Publication: 2020 May 22.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Silencing*
STAT3 Transcription Factor*
Alzheimer Disease/*genetics
Alzheimer Disease/therapy ; Animals ; Astrocytes/metabolism ; Cells, Cultured ; Disease Models, Animal ; Mice, Transgenic ; Molecular Targeted Therapy ; Phosphorylation
Czasopismo naukowe
Tytuł :
Down-regulation of microRNA-34c-5p alleviates neuropathic pain via the SIRT1/STAT3 signaling pathway in rat models of chronic constriction injury of sciatic nerve.
Autorzy :
Mo Y; Department of Anesthesiology, Linyi People's Hospital, Linyi, P.R. China.
Liu B; Department of Anesthesiology, Linyi People's Hospital, Linyi, P.R. China.
Qiu S; Department of Anesthesiology, Linyi People's Hospital, Linyi, P.R. China.
Wang X; Department of Anesthesiology, Linyi People's Hospital, Linyi, P.R. China.
Zhong L; Department of Anesthesiology, Linyi People's Hospital, Linyi, P.R. China.
Han X; Department of Anesthesiology, Linyi People's Hospital, Linyi, P.R. China.
Mi F; Department of Anesthesiology, Linyi People's Hospital, Linyi, P.R. China.
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Źródło :
Journal of neurochemistry [J Neurochem] 2020 Aug; Vol. 154 (3), pp. 301-315. Date of Electronic Publication: 2020 Mar 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation/*genetics
MicroRNAs/*metabolism
Neuralgia/*metabolism
STAT3 Transcription Factor/*metabolism
Sirtuin 1/*metabolism
Animals ; Constriction, Pathologic ; Disease Models, Animal ; Down-Regulation ; Male ; MicroRNAs/genetics ; Neuralgia/genetics ; Rats ; Rats, Sprague-Dawley ; STAT3 Transcription Factor/genetics ; Sciatic Nerve/injuries ; Signal Transduction/physiology ; Sirtuin 1/genetics
Czasopismo naukowe
Tytuł :
A novel small molecule STAT3 inhibitor SLSI-1216 suppresses proliferation and tumor growth of triple-negative breast cancer cells through apoptotic induction.
Autorzy :
Park SK; College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 08826, Republic of Korea.
Byun WS; College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 08826, Republic of Korea.
Lee S; College of Pharmacy, CHA University, Gyeonggi-do 11160, Republic of Korea.
Han YT; College of Pharmacy, Dankook University, Cheonan 31116, Republic of Korea.
Jeong YS; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Jang K; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Chung SJ; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Lee J; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Suh YG; College of Pharmacy, CHA University, Gyeonggi-do 11160, Republic of Korea. Electronic address: .
Lee SK; College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Aug; Vol. 178, pp. 114053. Date of Electronic Publication: 2020 May 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Cell Proliferation/*drug effects
Growth Inhibitors/*pharmacology
STAT3 Transcription Factor/*antagonists & inhibitors
Triple Negative Breast Neoplasms/*metabolism
Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Apoptosis/physiology ; Cell Line, Tumor ; Cell Proliferation/physiology ; Female ; Growth Inhibitors/chemistry ; Growth Inhibitors/therapeutic use ; HEK293 Cells ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; STAT3 Transcription Factor/metabolism ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/pathology ; Tumor Burden/drug effects ; Tumor Burden/physiology ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Label-free detection of cancer related gene based on target recycling and palindrome-mediated strand displacement amplification.
Autorzy :
Xu H; Key Laboratory of Laboratory Medicine, Ministry of Education of China, And Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China; Cancer Metastasis Alert and Prevention Center, Biopharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, And Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350002, China; Institute of Oceanography, Minjiang University, Fuzhou, Fujian, 350108, China.
Wu B; Key Laboratory of Laboratory Medicine, Ministry of Education of China, And Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Wang J; Key Laboratory of Laboratory Medicine, Ministry of Education of China, And Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China; Cancer Metastasis Alert and Prevention Center, Biopharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, And Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350002, China.
Cao H; Key Laboratory of Laboratory Medicine, Ministry of Education of China, And Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Yang J; Key Laboratory of Laboratory Medicine, Ministry of Education of China, And Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Hao K; Key Laboratory of Laboratory Medicine, Ministry of Education of China, And Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Chen S; Key Laboratory of Laboratory Medicine, Ministry of Education of China, And Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Ye S; Key Laboratory of Laboratory Medicine, Ministry of Education of China, And Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China. Electronic address: .
Shen Z; Key Laboratory of Laboratory Medicine, Ministry of Education of China, And Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China. Electronic address: .
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Źródło :
Talanta [Talanta] 2020 Aug 01; Vol. 215, pp. 120897. Date of Electronic Publication: 2020 Mar 06.
Typ publikacji :
Journal Article
MeSH Terms :
Biosensing Techniques*
Nucleic Acid Amplification Techniques*
Biomarkers, Tumor/*genetics
STAT3 Transcription Factor/*genetics
Biomarkers, Tumor/blood ; DNA, Neoplasm/genetics ; Humans ; Particle Size ; STAT3 Transcription Factor/blood ; Surface Properties
Czasopismo naukowe

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