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Tytuł:
Crosstalk between KDEL receptor and EGF receptor mediates cell proliferation and migration via STAT3 signaling.
Autorzy:
Jia J; School of Life Science and Technology, ShanghaiTech University, Pudong, Shanghai, China.
Zhu L; School of Life Science and Technology, ShanghaiTech University, Pudong, Shanghai, China.
Yue X; School of Life Science and Technology, ShanghaiTech University, Pudong, Shanghai, China.
Tang S; School of Life Science and Technology, ShanghaiTech University, Pudong, Shanghai, China.
Jing S; School of Life Science and Technology, ShanghaiTech University, Pudong, Shanghai, China.; Present address: Department of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Tan C; School of Life Science and Technology, ShanghaiTech University, Pudong, Shanghai, China.
Du Y; School of Life Science and Technology, ShanghaiTech University, Pudong, Shanghai, China.
Gao J; School of Life Science and Technology, ShanghaiTech University, Pudong, Shanghai, China.
Lee I; School of Life Science and Technology, ShanghaiTech University, Pudong, Shanghai, China. .
Qian Y; School of Life Science and Technology, ShanghaiTech University, Pudong, Shanghai, China. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2024 Feb 20; Vol. 22 (1), pp. 140. Date of Electronic Publication: 2024 Feb 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Signal Transduction*
ErbB Receptors*/metabolism
Receptors, Peptide*
Humans ; Ligands ; Molecular Chaperones/metabolism ; Cell Proliferation ; Tyrosine ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Non-canonical STAT3 function reduces REDD1 transcription.
Autorzy:
Köhler N; Department of Systems Biology, Institute of Biology, Otto-von-Guericke University Magdeburg, Germany.
Wundrack N; Department of Systems Biology, Institute of Biology, Otto-von-Guericke University Magdeburg, Germany.
Schulz S; Department of Systems Biology, Institute of Biology, Otto-von-Guericke University Magdeburg, Germany.
Bartonitz F; Department of Systems Biology, Institute of Biology, Otto-von-Guericke University Magdeburg, Germany.
Schaper F; Department of Systems Biology, Institute of Biology, Otto-von-Guericke University Magdeburg, Germany.; Center for Dynamic Systems: Systems Engineering (CDS), Otto-von-Guericke University Magdeburg, Germany.; Magdeburg Center for Systems Biology (MACS), Otto-von-Guericke University Magdeburg, Germany.
Dittrich A; Department of Systems Biology, Institute of Biology, Otto-von-Guericke University Magdeburg, Germany.; Center for Dynamic Systems: Systems Engineering (CDS), Otto-von-Guericke University Magdeburg, Germany.; Magdeburg Center for Systems Biology (MACS), Otto-von-Guericke University Magdeburg, Germany.
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Źródło:
The FEBS journal [FEBS J] 2023 Apr; Vol. 290 (7), pp. 1765-1781. Date of Electronic Publication: 2022 Dec 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Signal Transduction*
STAT3 Transcription Factor*/genetics
STAT3 Transcription Factor*/metabolism
Gene Expression Regulation ; Transcription, Genetic ; STAT1 Transcription Factor/genetics ; RNA, Messenger/genetics ; Transcriptional Activation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
KLF13 Regulates the Activity of the GH-Induced JAK/STAT Signaling by Targeting Genes Involved in the Pathway.
Autorzy:
Ávila-Mendoza J; Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional Autónoma de México, Querétaro 76230, Mexico.
Delgado-Rueda K; Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional Autónoma de México, Querétaro 76230, Mexico.
Urban-Sosa VA; Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional Autónoma de México, Querétaro 76230, Mexico.
Carranza M; Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional Autónoma de México, Querétaro 76230, Mexico.
Luna M; Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional Autónoma de México, Querétaro 76230, Mexico.
Martínez-Moreno CG; Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional Autónoma de México, Querétaro 76230, Mexico.
Arámburo C; Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus Juriquilla, Universidad Nacional Autónoma de México, Querétaro 76230, Mexico.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 07; Vol. 24 (13). Date of Electronic Publication: 2023 Jul 07.
Typ publikacji:
Journal Article
MeSH Terms:
Signal Transduction*
Janus Kinases*/genetics
Janus Kinases*/metabolism
STAT Transcription Factors/genetics ; STAT Transcription Factors/metabolism ; Suppressor of Cytokine Signaling Proteins/metabolism ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; RNA, Messenger/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Novel Ageladine A Derivative Acts as a STAT3 Inhibitor and Exhibits Potential Antitumor Effects.
Autorzy:
He N; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Innovation Platform of Marine Drug Screening & Evaluation, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266100, China.
Li L; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao 266237, China.
Li R; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Innovation Platform of Marine Drug Screening & Evaluation, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266100, China.
Zhang SQ; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Innovation Platform of Marine Drug Screening & Evaluation, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266100, China.
Wu LH; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Innovation Platform of Marine Drug Screening & Evaluation, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266100, China.
Guan X; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao 266237, China.
Zhang QY; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Innovation Platform of Marine Drug Screening & Evaluation, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266100, China.
Jiang T; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao 266237, China.
Yang JB; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Innovation Platform of Marine Drug Screening & Evaluation, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266100, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 16; Vol. 24 (10). Date of Electronic Publication: 2023 May 16.
Typ publikacji:
Journal Article
MeSH Terms:
Signal Transduction*
Janus Kinases*/metabolism
Humans ; Molecular Docking Simulation ; Cell Line, Tumor ; Phosphorylation ; STAT3 Transcription Factor/metabolism ; Cell Proliferation ; Xenograft Model Antitumor Assays ; Apoptosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The role of understudied post-translational modifications for the behavior and function of Signal Transducer and Activator of Transcription 3.
Autorzy:
Diallo M; Faculdade de Ciências da Universidade de Lisboa, Cell Structure and Dynamics Laboratory, BioISI - Instituto de Biosistemas e Ciências integrativas, Lisbon, Portugal.; MOSTMICRO Research Unit, Instituto de Tecnologia Química e Biológica (ITQB-NOVA), Universidade Nova de Lisboa, Oeiras, Portugal.
Herrera F; Faculdade de Ciências da Universidade de Lisboa, Cell Structure and Dynamics Laboratory, BioISI - Instituto de Biosistemas e Ciências integrativas, Lisbon, Portugal.; MOSTMICRO Research Unit, Instituto de Tecnologia Química e Biológica (ITQB-NOVA), Universidade Nova de Lisboa, Oeiras, Portugal.
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Źródło:
The FEBS journal [FEBS J] 2022 Oct; Vol. 289 (20), pp. 6235-6255. Date of Electronic Publication: 2021 Jul 17.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
STAT3 Transcription Factor*/genetics
STAT3 Transcription Factor*/metabolism
Signal Transduction*
Phosphorylation ; Protein Processing, Post-Translational ; STAT1 Transcription Factor/metabolism ; Tyrosine/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hoxa5 inhibits adipocyte proliferation through transcriptional regulation of Ccne1 and blocking JAK2/STAT3 signaling pathway in mice.
Autorzy:
Pan M; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
Sun Q; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
Li C; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
Tai R; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
Shi X; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
Sun C; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
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Źródło:
Biochemistry and cell biology = Biochimie et biologie cellulaire [Biochem Cell Biol] 2022 Aug 01; Vol. 100 (4), pp. 325-337. Date of Electronic Publication: 2022 May 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adipocytes*/cytology
Cyclin E*/genetics
Cyclin E*/metabolism
Homeodomain Proteins*/genetics
Homeodomain Proteins*/metabolism
Janus Kinase 2*/genetics
Janus Kinase 2*/metabolism
STAT3 Transcription Factor*/genetics
STAT3 Transcription Factor*/metabolism
Signal Transduction*
Animals ; Cell Proliferation ; Mice ; Obesity/genetics ; Obesity/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Discovery of Novel Polycyclic Polyprenylated Acylphloroglucinols from the Fruits of Garcinia xanthochymus as Antitumor Agents by Suppressing the STAT3 Signaling.
Autorzy:
Jin S; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Wang W; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Gan F; College of Chemistry and Material Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Xie W; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Xu J; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Chen Y; College of Chemistry and Material Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Mei Z; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Yang G; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 26; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 26.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents, Phytogenic*/chemistry
Antineoplastic Agents, Phytogenic*/pharmacology
Neoplasm Proteins*/chemistry
Neoplasm Proteins*/metabolism
Phloroglucinol*/analogs & derivatives
Phloroglucinol*/chemistry
Phloroglucinol*/pharmacology
STAT3 Transcription Factor*/chemistry
STAT3 Transcription Factor*/metabolism
Fruit/*chemistry
Garcinia/*chemistry
Signal Transduction/*drug effects
A549 Cells ; Hep G2 Cells ; Humans ; MCF-7 Cells ; Molecular Dynamics Simulation ; Protein Domains
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effects of Aurora kinase A on mouse decidualization via Stat3-plk1-cdk1 pathway.
Autorzy:
Wang PC; College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, China.; College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Chen ST; College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Yang ZM; College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. .
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Źródło:
Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2021 Oct 29; Vol. 19 (1), pp. 162. Date of Electronic Publication: 2021 Oct 29.
Typ publikacji:
Journal Article
MeSH Terms:
Aurora Kinase A/*biosynthesis
CDC2 Protein Kinase/*metabolism
Cell Cycle Proteins/*metabolism
Decidua/*metabolism
Protein Serine-Threonine Kinases/*metabolism
Proto-Oncogene Proteins/*metabolism
STAT3 Transcription Factor/*metabolism
Signal Transduction/*physiology
Animals ; Aurora Kinase A/antagonists & inhibitors ; CDC2 Protein Kinase/antagonists & inhibitors ; Cell Cycle Proteins/antagonists & inhibitors ; Cells, Cultured ; Decidua/drug effects ; Enzyme Inhibitors/pharmacology ; Female ; Mice ; Pregnancy ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Proto-Oncogene Proteins/antagonists & inhibitors ; STAT3 Transcription Factor/antagonists & inhibitors ; Signal Transduction/drug effects ; Polo-Like Kinase 1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The synthesis of novel thioderivative chalcones and their influence on NF-κB, STAT3 and NRF2 signaling pathways in colorectal cancer cells.
Autorzy:
Papierska K; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Święcickiego 4, 60-781, Poznań, Poland.
Krajka-Kuźniak V; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Święcickiego 4, 60-781, Poznań, Poland. .
Kleszcz R; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Święcickiego 4, 60-781, Poznań, Poland.
Stefański T; Faculty of Chemistry, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 8, 61-712, Poznań, Poland.
Kurczab R; Department of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343, Krakow, Poland.
Kubicki M; Faculty of Chemistry, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 8, 61-712, Poznań, Poland. .
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Źródło:
Scientific reports [Sci Rep] 2022 Sep 01; Vol. 12 (1), pp. 14915. Date of Electronic Publication: 2022 Sep 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chalcone*/chemistry
Chalcones*/chemistry
Chalcones*/pharmacology
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/metabolism
Signal Transduction*/drug effects
Humans ; NF-E2-Related Factor 2/drug effects ; NF-E2-Related Factor 2/metabolism ; NF-kappa B/drug effects ; NF-kappa B/metabolism ; STAT3 Transcription Factor/drug effects ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway.
Autorzy:
Seo HY; Department of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, Korea.
Lee SH; Department of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, Korea.
Lee JH; Department of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, Korea.
Lee JH; Department of Anatomy, Keimyung University School of Medicine, Dageu 42601, Korea.
Jang BK; Department of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, Korea.
Kim MK; Department of Internal Medicine, School of Medicine, Institute for Medical Science, Keimyung University, Daegu 42601, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 29; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 29.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Carcinoma, Hepatocellular/*metabolism
Diterpenes/*pharmacology
Liver Neoplasms/*metabolism
STAT3 Transcription Factor/*metabolism
Signal Transduction/*drug effects
TOR Serine-Threonine Kinases/*metabolism
src-Family Kinases/*metabolism
Animals ; Apoptosis/genetics ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Phosphorylation/drug effects ; RNA-Seq/methods ; STAT3 Transcription Factor/genetics ; Signal Transduction/genetics ; Survival Analysis ; TOR Serine-Threonine Kinases/genetics ; src-Family Kinases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Non-toxic sulfur inhibits LPS-induced inflammation by regulating TLR-4 and JAK2/STAT3 through IL-6 signaling.
Autorzy:
Kang DY; Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Chungju, North Chungcheong 27478, Republic of Korea.
Sp N; Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Chungju, North Chungcheong 27478, Republic of Korea.
Jo ES; Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Chungju, North Chungcheong 27478, Republic of Korea.
Rugamba A; Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Chungju, North Chungcheong 27478, Republic of Korea.
Kim HD; Nara Bio Co., Ltd., Gunsan, Jeollabuk-do 54006, Republic of Korea.
Kim IH; Nara Bio Co., Ltd., Gunsan, Jeollabuk-do 54006, Republic of Korea.
Park JC; Plant Genome Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon 34141, Republic of Korea.
Bae SW; Department of Chemistry and Cosmetics, Jeju National University, Jeju-si, Jeju-do 63243, Republic of Korea.
Jang KJ; Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Chungju, North Chungcheong 27478, Republic of Korea.
Yang YM; Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Chungju, North Chungcheong 27478, Republic of Korea.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2021 Jul; Vol. 24 (1). Date of Electronic Publication: 2021 Apr 28.
Typ publikacji:
Journal Article
MeSH Terms:
Inflammation/*drug therapy
Interleukin-6/*metabolism
Janus Kinase 2/*metabolism
Lipopolysaccharides/*adverse effects
STAT3 Transcription Factor/*metabolism
Signal Transduction/*drug effects
Sulfur/*pharmacology
Toll-Like Receptor 4/*metabolism
Animals ; Cell Line ; Cytokines/metabolism ; Gene Expression Regulation ; Inflammation/chemically induced ; Inflammation/genetics ; Janus Kinase 2/genetics ; Mice ; STAT3 Transcription Factor/genetics ; Toll-Like Receptor 4/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Emerin Represses STAT3 Signaling through Nuclear Membrane-Based Spatial Control.
Autorzy:
Lee B; Department of Bioresources Engineering, Sejong University, Seoul 05006, Korea.
Lee S; Department of Bioresources Engineering, Sejong University, Seoul 05006, Korea.
Lee Y; Department of Bioresources Engineering, Sejong University, Seoul 05006, Korea.
Park Y; Department of Bioresources Engineering, Sejong University, Seoul 05006, Korea.
Shim J; Department of Bioresources Engineering, Sejong University, Seoul 05006, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 22; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 22.
Typ publikacji:
Journal Article
MeSH Terms:
Signal Transduction*
Membrane Proteins/*metabolism
Nuclear Envelope/*metabolism
Nuclear Proteins/*metabolism
STAT3 Transcription Factor/*metabolism
A549 Cells ; Cell Nucleus/metabolism ; Cell Survival ; Gene Expression Regulation ; Humans ; Janus Kinases/metabolism ; Muscle, Skeletal/metabolism ; Muscular Dystrophies/etiology ; Muscular Dystrophies/metabolism ; Muscular Dystrophies/pathology ; Mutation ; Protein Binding ; STAT3 Transcription Factor/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chidamide induces apoptosis in DLBCL cells by suppressing the HDACs/STAT3/Bcl‑2 pathway.
Autorzy:
Zhang H; Department of Hematology, Cancer Hospital of Shanxi Province, Taiyuan, Shanxi 030013, P.R. China.
Chi F; Department of Biochemistry and Molecular Biology, Key Laboratory of Cellular Physiology of Ministry of Education, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.
Qin K; Department of Biochemistry and Molecular Biology, Key Laboratory of Cellular Physiology of Ministry of Education, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.
Mu X; Department of Biochemistry and Molecular Biology, Key Laboratory of Cellular Physiology of Ministry of Education, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.
Wang L; Department of Hematology, Cancer Hospital of Shanxi Province, Taiyuan, Shanxi 030013, P.R. China.
Yang B; Department of Hematology, Cancer Hospital of Shanxi Province, Taiyuan, Shanxi 030013, P.R. China.
Wang Y; Department of Hematology, Cancer Hospital of Shanxi Province, Taiyuan, Shanxi 030013, P.R. China.
Bai M; Department of Hematology, Cancer Hospital of Shanxi Province, Taiyuan, Shanxi 030013, P.R. China.
Li Z; Department of Hematology, Cancer Hospital of Shanxi Province, Taiyuan, Shanxi 030013, P.R. China.
Su L; Department of Hematology, Cancer Hospital of Shanxi Province, Taiyuan, Shanxi 030013, P.R. China.
Yu B; Department of Biochemistry and Molecular Biology, Key Laboratory of Cellular Physiology of Ministry of Education, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2021 May; Vol. 23 (5). Date of Electronic Publication: 2021 Mar 02.
Typ publikacji:
Journal Article
MeSH Terms:
Aminopyridines/*pharmacology
Apoptosis/*drug effects
Benzamides/*pharmacology
Histone Deacetylases/*metabolism
Proto-Oncogene Proteins c-bcl-2/*metabolism
STAT3 Transcription Factor/*metabolism
Signal Transduction/*drug effects
Caspase 3/metabolism ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Gene Expression/drug effects ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Isoenzymes/metabolism ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/metabolism ; Lymphoma, Large B-Cell, Diffuse/pathology ; Phosphorylation/drug effects ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Glutathione S‑transferase ω 1 promotes the proliferation, migration and invasion, and inhibits the apoptosis of non‑small cell lung cancer cells, via the JAK/STAT3 signaling pathway.
Autorzy:
Wang K; Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital, Tianjin 300222, P.R. China.
Zhang FL; Integrated TCM and Western Medicine Department, Tianjin Medical University Chu Hsien‑I Memorial Hospital, Tianjin 300134, P.R. China.
Jia W; Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital, Tianjin 300222, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2021 Jan; Vol. 23 (1). Date of Electronic Publication: 2020 Nov 25.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/metabolism
Carcinoma, Non-Small-Cell Lung*/pathology
Cell Movement*
Cell Proliferation*
Glutathione Transferase*/genetics
Glutathione Transferase*/metabolism
Janus Kinases*/genetics
Janus Kinases*/metabolism
Lung Neoplasms*/genetics
Lung Neoplasms*/metabolism
Lung Neoplasms*/pathology
Neoplasm Proteins*/genetics
Neoplasm Proteins*/metabolism
STAT3 Transcription Factor*/genetics
STAT3 Transcription Factor*/metabolism
Signal Transduction*
A549 Cells ; Humans ; Neoplasm Invasiveness
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A novel small molecule LLL12B inhibits STAT3 signaling and sensitizes ovarian cancer cell to paclitaxel and cisplatin.
Autorzy:
Zhang R; Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Yang X; Department of Medicinal Chemistry, College of Pharmacy, The University of Florida, Gainesville, Florida, United States of America.
Roque DM; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Li C; Department of Medicinal Chemistry, College of Pharmacy, The University of Florida, Gainesville, Florida, United States of America.
Lin J; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
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Źródło:
PloS one [PLoS One] 2021 Apr 28; Vol. 16 (4), pp. e0240145. Date of Electronic Publication: 2021 Apr 28 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/metabolism
Anthraquinones/*pharmacology
Cisplatin/*pharmacology
Neoplasm Proteins/*antagonists & inhibitors
Paclitaxel/*pharmacology
STAT3 Transcription Factor/*antagonists & inhibitors
Signal Transduction/*drug effects
Sulfonamides/*pharmacology
Cell Line, Tumor ; Female ; Humans ; Neoplasm Proteins/metabolism ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
cGAS-STING cytosolic DNA sensing pathway is suppressed by JAK2-STAT3 in tumor cells.
Autorzy:
Suter MA; Department of Microbiology, Immunology Programme, National University of Singapore, Singapore, 117456, Singapore.
Tan NY; Department of Microbiology, Immunology Programme, National University of Singapore, Singapore, 117456, Singapore.
Thiam CH; Department of Microbiology, Immunology Programme, National University of Singapore, Singapore, 117456, Singapore.
Khatoo M; Department of Microbiology, Immunology Programme, National University of Singapore, Singapore, 117456, Singapore.
MacAry PA; Department of Microbiology, Immunology Programme, National University of Singapore, Singapore, 117456, Singapore.
Angeli V; Department of Microbiology, Immunology Programme, National University of Singapore, Singapore, 117456, Singapore.
Gasser S; Department of Microbiology, Immunology Programme, National University of Singapore, Singapore, 117456, Singapore.; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, 117597, Singapore.
Zhang YL; Department of Microbiology, Immunology Programme, National University of Singapore, Singapore, 117456, Singapore. .
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Źródło:
Scientific reports [Sci Rep] 2021 Mar 31; Vol. 11 (1), pp. 7243. Date of Electronic Publication: 2021 Mar 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Signal Transduction*
Janus Kinase 2/*metabolism
Membrane Proteins/*metabolism
Neoplasms/*metabolism
Nucleotidyltransferases/*metabolism
STAT3 Transcription Factor/*metabolism
A549 Cells ; Animals ; HeLa Cells ; Humans ; Janus Kinase 2/genetics ; Male ; Membrane Proteins/genetics ; Mice ; Neoplasms/genetics ; Nucleotidyltransferases/genetics ; STAT3 Transcription Factor/genetics ; THP-1 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Alantolactone induces apoptosis in THP-1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway.
Autorzy:
Ahmad B; College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Gamallat Y; College of Basic Medical Sciences, Dalian Medical University, Dalian, China.; Guangzhou Institute of Pediatrics, Guangzhou Women and Childrens Medical Center, Guangzhou, China.
Su P; College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Husain A; College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Rehman AU; College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Zaky MY; College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Bakheet AMH; The Third Affiliated Hospital of Sun-yat Sen University, Guangzhou, China.
Tahir N; College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Xin Y; College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Liang W; Stem Cell Clinical Research Center, National Joint Engineering Laboratory, Regenerative Medicine Center, The First Affiliated Hospital of Dalian Medical, Dalian City, China.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2021 Feb; Vol. 97 (2), pp. 266-272. Date of Electronic Publication: 2020 Sep 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*drug effects
Lactones/*pharmacology
STAT3 Transcription Factor/*metabolism
Sesquiterpenes, Eudesmane/*pharmacology
Signal Transduction/*drug effects
Survivin/*metabolism
Cell Survival/drug effects ; Humans ; Inula/chemistry ; Inula/metabolism ; Mitochondria/drug effects ; Mitochondria/metabolism ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; STAT3 Transcription Factor/antagonists & inhibitors ; Survivin/antagonists & inhibitors ; THP-1 Cells ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
JAK2/STAT3 involves oxidative stress-induced cell injury in N2a cells and a rat MCAO model.
Autorzy:
Sun Y; Department of Cell Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Cheng M; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China.
Liang X; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China.
Chen S; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China.
Wang M; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China.
Zhang X; Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China.
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Źródło:
The International journal of neuroscience [Int J Neurosci] 2020 Nov; Vol. 130 (11), pp. 1142-1150. Date of Electronic Publication: 2020 Feb 24.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*/drug effects
Neuroblastoma*
Oxidative Stress*/drug effects
Signal Transduction*/drug effects
Enzyme Inhibitors/*pharmacology
Hydrogen Peroxide/*pharmacology
Infarction, Middle Cerebral Artery/*metabolism
Janus Kinase 2/*metabolism
Oxidants/*pharmacology
Reperfusion Injury/*metabolism
STAT3 Transcription Factor/*metabolism
8-Hydroxy-2'-Deoxyguanosine/metabolism ; Animals ; Cell Line, Tumor ; Cell Survival/drug effects ; Disease Models, Animal ; Janus Kinase 2/antagonists & inhibitors ; Janus Kinase 2/drug effects ; Mice ; Rats ; STAT3 Transcription Factor/drug effects ; Tyrphostins/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Role of TGM2 in T‑cell lymphoblastic lymphoma via regulation of IL‑6/JAK/STAT3 signalling.
Autorzy:
Wang Y; Department of Laboratory, Shengli Oilfield Central Hospital, Dongying, Shandong 257034, P.R. China.
Zheng N; Department of Laboratory, Shengli Oilfield Central Hospital, Dongying, Shandong 257034, P.R. China.
Sun T; Department of Laboratory, Shengli Oilfield Central Hospital, Dongying, Shandong 257034, P.R. China.
Zhao H; Department of Laboratory, Shengli Oilfield Central Hospital, Dongying, Shandong 257034, P.R. China.
Chen Y; Department of Laboratory, Shengli Oilfield Central Hospital, Dongying, Shandong 257034, P.R. China.
Liu C; Department of Laboratory, Shengli Oilfield Central Hospital, Dongying, Shandong 257034, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2022 Mar; Vol. 25 (3). Date of Electronic Publication: 2022 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Signal Transduction*
Interleukin-6/*metabolism
Janus Kinases/*metabolism
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*etiology
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*metabolism
Protein Glutamine gamma Glutamyltransferase 2/*genetics
STAT3 Transcription Factor/*metabolism
Apoptosis/genetics ; Cell Line, Tumor ; Databases, Genetic ; Disease Susceptibility ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Protein Glutamine gamma Glutamyltransferase 2/metabolism ; RNA Interference
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Ginsenoside Rh4 Suppressed Metastasis of Lung Adenocarcinoma via Inhibiting JAK2/STAT3 Signaling.
Autorzy:
Zhang Y; Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, China.; Biotech & Biomed Research Institute, Northwest University, Xi'an 710069, China.
Ma P; Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, China.; Biotech & Biomed Research Institute, Northwest University, Xi'an 710069, China.
Duan Z; Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, China.; Biotech & Biomed Research Institute, Northwest University, Xi'an 710069, China.
Liu Y; Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, China.; Biotech & Biomed Research Institute, Northwest University, Xi'an 710069, China.
Mi Y; Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, China.; Biotech & Biomed Research Institute, Northwest University, Xi'an 710069, China.
Fan D; Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, China.; Biotech & Biomed Research Institute, Northwest University, Xi'an 710069, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Feb 11; Vol. 23 (4). Date of Electronic Publication: 2022 Feb 11.
Typ publikacji:
Journal Article
MeSH Terms:
Adenocarcinoma of Lung/*drug therapy
Ginsenosides/*pharmacology
Janus Kinase 2/*metabolism
Lung Neoplasms/*drug therapy
STAT3 Transcription Factor/*metabolism
Signal Transduction/*drug effects
A549 Cells ; Adenocarcinoma of Lung/metabolism ; Animals ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Female ; Humans ; Lung Neoplasms/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Invasiveness/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 753

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