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Tytuł :
Enhanced anti-tumor effects of the PD-1 blockade combined with a highly absorptive form of curcumin targeting STAT3.
Autorzy :
Hayakawa T; Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.
Yaguchi T; Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.
Kawakami Y; Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.; Department of Immunology, School of Medicine, International University of Health and Welfare, Chiba, Japan.
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Źródło :
Cancer science [Cancer Sci] 2020 Dec; Vol. 111 (12), pp. 4326-4335. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Curcumin/*therapeutic use
Dendritic Cells/*metabolism
Immune Checkpoint Inhibitors/*therapeutic use
Neoplasms/*therapy
STAT3 Transcription Factor/*antagonists & inhibitors
Animals ; Dendritic Cells/immunology ; Drug Therapy, Combination/methods ; Female ; Humans ; Immunotherapy/methods ; Interferon-gamma/metabolism ; Interleukin-6/biosynthesis ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Nude ; NF-kappa B/analysis ; Neoplasms/immunology ; Plant Extracts/therapeutic use ; STAT3 Transcription Factor/analysis ; STAT3 Transcription Factor/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy.
Autorzy :
Gregory JV; Biointerfaces Institute, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.; Chemical Engineering, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.
Kadiyala P; Department of Neurosurgery, University of Michigan Medical School, 1500 E. Medical Center Drive SPC 5338, Ann Arbor, MI, 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI, 48109, USA.
Doherty R; Department of Neurosurgery, University of Michigan Medical School, 1500 E. Medical Center Drive SPC 5338, Ann Arbor, MI, 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI, 48109, USA.
Cadena M; Biointerfaces Institute, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.; Biomedical Engineering, University of Michigan, 2200 Bonisteel Blvd, Ann Arbor, MI, 48109, USA.
Habeel S; Biointerfaces Institute, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.; Biomedical Engineering, University of Michigan, 2200 Bonisteel Blvd, Ann Arbor, MI, 48109, USA.
Ruoslahti E; Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA.; Center for Nanomedicine and Department of Cell, Molecular and Developmental Biology, Building 235, University of California, Santa Barbara, Santa Barbara, CA, 93106, USA.
Lowenstein PR; Biointerfaces Institute, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.; Department of Neurosurgery, University of Michigan Medical School, 1500 E. Medical Center Drive SPC 5338, Ann Arbor, MI, 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI, 48109, USA.
Castro MG; Biointerfaces Institute, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA. .; Department of Neurosurgery, University of Michigan Medical School, 1500 E. Medical Center Drive SPC 5338, Ann Arbor, MI, 48109, USA. .; Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI, 48109, USA. .
Lahann J; Biointerfaces Institute, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA. .; Chemical Engineering, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA. .; Biomedical Engineering, University of Michigan, 2200 Bonisteel Blvd, Ann Arbor, MI, 48109, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 10; Vol. 11 (1), pp. 5687. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Delivery Systems*
Nanoparticles*/chemistry
Nanoparticles*/therapeutic use
Glioblastoma/*drug therapy
STAT3 Transcription Factor/*metabolism
Animals ; Blood-Brain Barrier ; Brain Neoplasms/drug therapy ; Cell Line, Tumor ; Gene Silencing ; Humans ; Mice ; RNA, Small Interfering/metabolism ; STAT3 Transcription Factor/antagonists & inhibitors ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
Effect of the isoflavone corylin from cullen corylifolium on colorectal cancer growth, by targeting the STAT3 signaling pathway.
Autorzy :
Yang L; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Yao Y; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Bai Y; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; The Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, China.
Zheng D; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Zhou F; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Chen L; Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325600, China.
Hu W; The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Xiang Y; The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Zhao H; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; The Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, China.
Liu Z; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Wang L; The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Electronic address: .
Huang X; The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Electronic address: .
Zhao C; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China; The Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Jan; Vol. 80, pp. 153366. Date of Electronic Publication: 2020 Oct 03.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Colorectal Neoplasms/*drug therapy
Flavonoids/*pharmacology
STAT3 Transcription Factor/*metabolism
Animals ; Apoptosis/drug effects ; Caspase 3/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Dose-Response Relationship, Drug ; Fabaceae/chemistry ; Female ; Humans ; Mice, Inbred BALB C ; STAT3 Transcription Factor/genetics ; Signal Transduction/drug effects ; Up-Regulation/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Hyaloid Vasculature as a Major Source of STAT3 (Signal Transducer and Activator of Transcription 3) Myeloid Cells for Pathogenic Retinal Neovascularization in Oxygen-Induced Retinopathy.
Autorzy :
Hombrebueno JR; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).; Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, United Kingdom (J.R.H.).
Lynch A; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).
Byrne EM; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).
Obasanmi G; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).
Kissenpfennig A; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).
Chen M; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).
Xu H; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, United Kingdom (J.R.H., A.L., E.M.B., G.O., A.K., M.C., H.X.).
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Dec; Vol. 40 (12), pp. e367-e379. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Oxygen*
Macrophages/*metabolism
Retinal Neovascularization/*metabolism
Retinal Vessels/*metabolism
Retinopathy of Prematurity/*metabolism
STAT3 Transcription Factor/*metabolism
Animals ; Animals, Newborn ; Anthraquinones/pharmacology ; Disease Models, Animal ; Female ; Macrophages/drug effects ; Macrophages/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphorylation ; Retinal Neovascularization/etiology ; Retinal Neovascularization/pathology ; Retinal Neovascularization/prevention & control ; Retinal Vessels/drug effects ; Retinal Vessels/pathology ; Retinopathy of Prematurity/etiology ; Retinopathy of Prematurity/pathology ; Retinopathy of Prematurity/prevention & control ; STAT3 Transcription Factor/antagonists & inhibitors ; Signal Transduction ; Sulfonamides/pharmacology ; Suppressor of Cytokine Signaling 3 Protein/genetics ; Suppressor of Cytokine Signaling 3 Protein/metabolism
Czasopismo naukowe
Tytuł :
2-Thiopyrimidine/chalcone hybrids: design, synthesis, ADMET prediction, and anticancer evaluation as STAT3/STAT5a inhibitors.
Autorzy :
Lamie PF; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Philoppes JN; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 864-879.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Chalcone/*pharmacology
Pyrimidines/*pharmacology
STAT3 Transcription Factor/*antagonists & inhibitors
STAT5 Transcription Factor/*antagonists & inhibitors
Tumor Suppressor Proteins/*antagonists & inhibitors
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line ; Cell Proliferation/drug effects ; Chalcone/chemistry ; Dogs ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Pyrimidines/chemistry ; STAT3 Transcription Factor/metabolism ; STAT5 Transcription Factor/metabolism ; Structure-Activity Relationship ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe
Tytuł :
Physapubescin B enhances the sensitivity of gastric cancer cells to trametinib by inhibiting the STAT3 signaling pathway.
Autorzy :
Dai C; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, China.
Shen L; Institute of Basic Theory of TCM, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Jin W; College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310006, China.
Lv B; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, China.
Liu P; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, China.
Wang X; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, China.
Yin Y; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, China.
Fu Y; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, China.
Liang L; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, China.
Ma Z; School of Pharmaceutical Sciences, Zhejiang University, 866 Yu-Hang-Tang Road, Hangzhou 310058, PR China.
Zhang X; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
Wang Y; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, China. Electronic address: .
Xu D; Department of Colorectal Surgery, Wenling Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, Wenling, China. Electronic address: .
Chen Z; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Dec 01; Vol. 408, pp. 115273. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Mitogen-Activated Protein Kinase Kinases/*antagonists & inhibitors
Protein Kinase Inhibitors/*therapeutic use
Pyridones/*therapeutic use
Pyrimidinones/*therapeutic use
STAT3 Transcription Factor/*antagonists & inhibitors
Stomach Neoplasms/*drug therapy
Withanolides/*therapeutic use
Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Humans ; Mice, Nude ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Phosphorylation/drug effects ; Protein Kinase Inhibitors/pharmacology ; Pyridones/pharmacology ; Pyrimidinones/pharmacology ; STAT3 Transcription Factor/metabolism ; Signal Transduction/drug effects ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Withanolides/pharmacology
Czasopismo naukowe
Tytuł :
Febuxostat attenuates testosterone-induced benign prostatic hyperplasia in rats via inhibiting JAK/STAT axis.
Autorzy :
Abo-Youssef AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Afify H; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian-Russian University, Cairo, Egypt.
Azouz AA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Abdel-Rahman HM; Department of Forensic Medicine and Toxicology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abdel-Naim AB; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: .
Allam S; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
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Źródło :
Life sciences [Life Sci] 2020 Nov 01; Vol. 260, pp. 118414. Date of Electronic Publication: 2020 Sep 11.
Typ publikacji :
Journal Article
MeSH Terms :
Febuxostat/*pharmacology
Gene Expression Regulation, Neoplastic/*genetics
Gout Suppressants/*pharmacology
Janus Kinase 1/*metabolism
Prostatic Hyperplasia/*drug therapy
STAT3 Transcription Factor/*metabolism
Testosterone/*toxicity
Androgens/toxicity ; Animals ; Janus Kinase 1/genetics ; Male ; Prostatic Hyperplasia/chemically induced ; Prostatic Hyperplasia/metabolism ; Prostatic Hyperplasia/pathology ; Rats ; Rats, Wistar ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
Human cytomegalovirus protein UL136 activates the IL-6/STAT3 signal through MiR-138 and MiR-34c in gastric cancer cells.
Autorzy :
Shi L; Department of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, China.
Fan B; Department of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, China.
Chen D; Department of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, China.
Guo C; Department of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, China.
Xiang H; Department of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, China.
Nie Y; Department of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, China.
Zhong D; Department of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, China. .
Shi X; Department of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, China. .
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Źródło :
International journal of clinical oncology [Int J Clin Oncol] 2020 Nov; Vol. 25 (11), pp. 1936-1944. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
Interleukin-6/*metabolism
MicroRNAs/*metabolism
STAT3 Transcription Factor/*metabolism
Stomach Neoplasms/*metabolism
Stomach Neoplasms/*virology
Viral Proteins/*metabolism
3' Untranslated Regions ; Animals ; Binding Sites ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cytomegalovirus/genetics ; Cytomegalovirus Infections/metabolism ; Cytomegalovirus Infections/pathology ; Gene Expression Regulation, Neoplastic ; Host-Pathogen Interactions ; Humans ; Interleukin-6/genetics ; Male ; Mice, Inbred BALB C ; MicroRNAs/genetics ; STAT3 Transcription Factor/genetics ; Signal Transduction ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
STAT3 isoforms differentially affect ACE2 expression: A potential target for COVID-19 therapy.
Autorzy :
Shamir I; Department of Pediatric Critical Care Medicine, Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.
Abutbul-Amitai M; Department of Pediatric Critical Care Medicine, Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.
Abbas-Egbariya H; Department of Pediatric Critical Care Medicine, Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.
Pasmanik-Chor M; George S. Wise Faculty of Life Science, Bioinformatics Unit, Tel Aviv University, Tel Aviv, Israel.
Paret G; Department of Pediatric Critical Care Medicine, Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.; Sackler Medical School, Tel-Aviv University, Tel-Aviv, Israel.
Nevo-Caspi Y; Department of Pediatric Critical Care Medicine, Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2020 Nov; Vol. 24 (21), pp. 12864-12868. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme 2/*metabolism
STAT3 Transcription Factor/*metabolism
Angiotensin-Converting Enzyme 2/genetics ; Binding Sites ; COVID-19 ; Humans ; MCF-7 Cells ; Promoter Regions, Genetic ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; SARS-CoV-2/drug effects ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
Endothelin-1 stimulates preadipocyte growth via the PKC, STAT3, AMPK, c-JUN, ERK, sphingosine kinase, and sphingomyelinase pathways.
Autorzy :
Siao AC; Department of Life Sciences, National Central University, Taoyuan, Taiwan.
Lin YY; Department of Life Sciences, National Central University, Taoyuan, Taiwan.; Department of Emergency, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan.; National Defense Medical Center, Taipei, Taiwan.
Shih LJ; National Defense Medical Center, Taipei, Taiwan.; Medical Laboratory, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan.
Tsuei YW; Department of Emergency, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan.
Chuu CP; Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Miaoli County, Taiwan.
Kuo YC; Division of Gastroenterology, Landseed Hospital, Taoyuan, Taiwan.
Kao YH; Department of Life Sciences, National Central University, Taoyuan, Taiwan.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2020 Nov 01; Vol. 319 (5), pp. C839-C857. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipocytes/*drug effects
Endothelin-1/*pharmacology
JNK Mitogen-Activated Protein Kinases/*genetics
Protein Kinase C/*genetics
STAT3 Transcription Factor/*genetics
p38 Mitogen-Activated Protein Kinases/*genetics
3T3-L1 Cells ; Adipocytes/cytology ; Adipocytes/metabolism ; Animals ; Butadienes/pharmacology ; Cell Differentiation ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Endothelin Receptor Antagonists/pharmacology ; Extracellular Signal-Regulated MAP Kinases/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Gene Expression Regulation ; Imidazoles/pharmacology ; JNK Mitogen-Activated Protein Kinases/metabolism ; Mice ; Nitriles/pharmacology ; Oligopeptides/pharmacology ; Phosphotransferases (Alcohol Group Acceptor)/genetics ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Piperidines/pharmacology ; Protein Kinase C/metabolism ; Pyridines/pharmacology ; Receptors, Endothelin/genetics ; Receptors, Endothelin/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Sphingomyelin Phosphodiesterase/genetics ; Sphingomyelin Phosphodiesterase/metabolism ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
[Activation of JAK2/STAT3 pathway by CPU0213 alleviates myocardial ischemia-reperfusion and oxidative stress injury in rats].
Autorzy :
Liu Y; First Department of Cardiology, Second Affiliated Hospital of Hebei North University, Zhangjiakou 075100, China.
Li Y; Comprehensive Ward, Second Affiliated Hospital of Hebei North University, Zhangjiakou 075100, China.
Li C; Second Department of Cardiology, Second Affiliated Hospital of Hebei North University, Zhangjiakou 075100, China.
Wang J; First Department of Cardiology, Second Affiliated Hospital of Hebei North University, Zhangjiakou 075100, China.
Xu X; First Department of Cardiology, Second Affiliated Hospital of Hebei North University, Zhangjiakou 075100, China.
Li X; First Department of Cardiology, Second Affiliated Hospital of Hebei North University, Zhangjiakou 075100, China. *Corresponding author, E-mail: .
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Źródło :
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology [Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi] 2020 Nov; Vol. 36 (11), pp. 1009-1015.
Typ publikacji :
Journal Article
MeSH Terms :
Janus Kinase 2*/metabolism
Myocardial Reperfusion Injury*/chemically induced
Myocardial Reperfusion Injury*/drug therapy
Pyrazoles*/pharmacology
Pyrazoles*/therapeutic use
STAT3 Transcription Factor*/metabolism
Animals ; Apoptosis/drug effects ; Cells, Cultured ; Hydrogen Peroxide/toxicity ; Mice ; Oxidative Stress/drug effects ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Leptin, Resistin, and Proprotein Convertase Subtilisin/Kexin Type 9: The Role of STAT3.
Autorzy :
Macchi C; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy. Electronic address: .
Greco MF; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Botta M; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Sperandeo P; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Dongiovanni P; General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Valenti L; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy; Translational Medicine, Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Cicero AFG; Department of Medicine and Surgery Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Borghi C; Department of Medicine and Surgery Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Lupo MG; Department of Pharmaceutical and Pharmacological Sciences, Università degli Studi di Padova, Padova, Italy.
Romeo S; Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden; Clinical Nutrition Unit, Department of Medical and Surgical Science, Magna Graecia University, Catanzaro, Italy; Department of Cardiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Corsini A; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy; IRCCS MultiMedica, Sesto S. Giovanni, Milan, Italy.
Magni P; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy; IRCCS MultiMedica, Sesto S. Giovanni, Milan, Italy.
Ferri N; Department of Pharmaceutical and Pharmacological Sciences, Università degli Studi di Padova, Padova, Italy.
Ruscica M; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy. Electronic address: .
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Źródło :
The American journal of pathology [Am J Pathol] 2020 Nov; Vol. 190 (11), pp. 2226-2236. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Up-Regulation*
Leptin/*metabolism
Proprotein Convertase 9/*biosynthesis
Resistin/*metabolism
STAT3 Transcription Factor/*metabolism
Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Hep G2 Cells ; Humans ; Leptin/genetics ; Obesity/genetics ; Obesity/metabolism ; Obesity/pathology ; Proprotein Convertase 9/genetics ; Resistin/genetics ; Response Elements ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
Interleukin-23 drives expansion of Thelper 17 cells through epigenetic regulation by signal transducer and activators of transcription 3 in lupus patients.
Autorzy :
Lee S; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Nakayamada S; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Kubo S; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Yamagata K; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Yoshinari H; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
Tanaka Y; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu Japan.
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Źródło :
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2020 Oct 01; Vol. 59 (10), pp. 3058-3069.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-23/*pharmacology
Lupus Erythematosus, Systemic/*blood
STAT3 Transcription Factor/*blood
Th17 Cells/*drug effects
Azetidines/pharmacology ; CD4-Positive T-Lymphocytes/drug effects ; Cell Proliferation/drug effects ; Chromatin Immunoprecipitation/methods ; Epigenesis, Genetic ; Flow Cytometry ; Gene Expression ; Humans ; Interleukin-12/pharmacology ; Interleukins/pharmacology ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Nuclear Receptor Subfamily 1, Group F, Member 3/genetics ; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism ; Phosphorylation ; Purines/pharmacology ; Pyrazoles/pharmacology ; Real-Time Polymerase Chain Reaction/methods ; STAT3 Transcription Factor/drug effects ; STAT3 Transcription Factor/metabolism ; STAT4 Transcription Factor/metabolism ; Signal Transduction ; Sulfonamides/pharmacology ; Th17 Cells/metabolism
Czasopismo naukowe
Tytuł :
Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains.
Autorzy :
La Sala G; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL), Station 19, 1015, Lausanne, Switzerland.
Michiels C; Experimental Medicine Unit, De Duve Institute, Université catholique de Louvain, 1200, Brussels, Belgium.
Kükenshöner T; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL), Station 19, 1015, Lausanne, Switzerland.
Brandstoetter T; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Maurer B; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Koide A; Department of Medicine, New York University School of Medicine, 522 1st Avenue, New York, 10016, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, 522 1st Avenue, New York, 10016, NY, USA.
Lau K; Protein Crystallography Core Facility, School of Life Sciences, École polytechnique fédérale de Lausanne, Station 19, 1015, Lausanne, Switzerland.
Pojer F; Protein Crystallography Core Facility, School of Life Sciences, École polytechnique fédérale de Lausanne, Station 19, 1015, Lausanne, Switzerland.
Koide S; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, 522 1st Avenue, New York, 10016, NY, USA.; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, 522 1st Avenue, New York, 10016, NY, USA.
Sexl V; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Dumoutier L; Experimental Medicine Unit, De Duve Institute, Université catholique de Louvain, 1200, Brussels, Belgium.
Hantschel O; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL), Station 19, 1015, Lausanne, Switzerland. .; Faculty of Medicine, Institute of Physiological Chemistry, Philipps-University of Marburg, Karl-von-Frisch-Straße 1, 35032, Marburg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 17; Vol. 11 (1), pp. 4115. Date of Electronic Publication: 2020 Aug 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies/*metabolism
STAT3 Transcription Factor/*metabolism
A549 Cells ; Antibodies/genetics ; Blotting, Western ; Calorimetry ; Crystallography, X-Ray ; Flow Cytometry ; Fluorescence Polarization ; Fluorescent Antibody Technique ; Humans ; Mass Spectrometry ; Protein Binding ; Protein Domains/immunology ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/immunology ; Signal Transduction/genetics ; Signal Transduction/physiology ; Synthetic Biology
Czasopismo naukowe
Tytuł :
Dehydrodieugenol improved lung inflammation in an asthma model by inhibiting the STAT3/SOCS3 and MAPK pathways.
Autorzy :
Santana FPR; Department of Biological Science, Federal University of São Paulo, Diadema, SP, Brazil; Department of Medicine, School of Medicine, University of São Paulo, SP, Brazil.
da Silva RC; Department of Biological Science, Federal University of São Paulo, Diadema, SP, Brazil.
Ponci V; Department of Biological Science, Federal University of São Paulo, Diadema, SP, Brazil.
Pinheiro AJMCR; Universidade CEUMA, São Luís, MA, Brazil; Programa de Pós-Graduação da Rede BIONORTE, Brazil.
Olivo CR; Department of Medicine, School of Medicine, University of São Paulo, SP, Brazil.
Caperuto LC; Department of Biological Science, Federal University of São Paulo, Diadema, SP, Brazil.
Arantes-Costa FM; Department of Medicine, School of Medicine, University of São Paulo, SP, Brazil.
Claudio SR; Department of Bioscience, Federal University of São Paulo, Santos, Brazil.
Ribeiro DA; Department of Bioscience, Federal University of São Paulo, Santos, Brazil.
Tibério IFLC; Department of Medicine, School of Medicine, University of São Paulo, SP, Brazil.
Lima-Neto LG; Universidade CEUMA, São Luís, MA, Brazil; Programa de Pós-Graduação da Rede BIONORTE, Brazil.
Lago JHG; Center of Natural Sciences and Humanities, Federal University of ABC, Santo André, SP, Brazil.
Prado CM; Department of Bioscience, Federal University of São Paulo, Santos, Brazil. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Oct; Vol. 180, pp. 114175. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Asthma/*drug therapy
Eugenol/*analogs & derivatives
Lignans/*therapeutic use
MAP Kinase Signaling System/*drug effects
Pneumonia/*drug therapy
STAT3 Transcription Factor/*antagonists & inhibitors
Suppressor of Cytokine Signaling 3 Protein/*antagonists & inhibitors
Animals ; Asthma/metabolism ; Dose-Response Relationship, Drug ; Eugenol/isolation & purification ; Eugenol/pharmacology ; Eugenol/therapeutic use ; Lauraceae ; Lignans/isolation & purification ; Lignans/pharmacology ; MAP Kinase Signaling System/physiology ; Male ; Mice ; Mice, Inbred BALB C ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Pneumonia/metabolism ; RAW 264.7 Cells ; STAT3 Transcription Factor/metabolism ; Suppressor of Cytokine Signaling 3 Protein/metabolism
Czasopismo naukowe
Tytuł :
The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat.
Autorzy :
Fu G; School of Resource and Environmental Engineer, Wuhan University of Science and Technology, PR China; School of Public Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, PR China.
Dai J; Wuhan Center For Disease Control & Prevention, PR China.
Li Z; School of Public Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, PR China.
Chen F; Chest Hospital of Jingzhou City, PR China.
Liu L; School of Public Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, PR China.
Yi L; School of Public Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, PR China.
Teng Z; School of Public Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, PR China.
Quan C; School of Public Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, PR China.
Zhang L; School of Public Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, PR China.
Zhou T; School of Public Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, PR China.
Donkersley P; Lancaster Environment Centre, Lancaster University, UK.
Song S; School of Resource and Environmental Engineer, Wuhan University of Science and Technology, PR China; School of Public Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, PR China. Electronic address: .
Shi Y; School of Resource and Environmental Engineer, Wuhan University of Science and Technology, PR China; School of Public Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, PR China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Oct 01; Vol. 404, pp. 115151. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diethylhexyl Phthalate/*toxicity
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
STAT3 Transcription Factor/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Tumor Suppressor Protein p53/*metabolism
Animals ; Diethylhexyl Phthalate/administration & dosage ; Dose-Response Relationship, Drug ; Glutathione Peroxidase/genetics ; Glutathione Peroxidase/metabolism ; Male ; Malondialdehyde/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Rats ; Rats, Sprague-Dawley ; STAT3 Transcription Factor/genetics ; Sexual Maturation ; Superoxide Dismutase/genetics ; Superoxide Dismutase/metabolism ; TOR Serine-Threonine Kinases/genetics ; Testis/drug effects ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
STAT3 imparts BRCAness by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes.
Autorzy :
McIntosh MT; Child Health Research Institute, Department of Pediatrics, University of Florida, Gainesville, FL, United States of America.; Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL, United States of America.
Koganti S; Division of Infectious Diseases, Department of Pediatrics, Stony Brook University, Stony Brook, NY, United States of America.
Boatwright JL; Bioinformatics Core Facility, University of Florida, Gainesville, FL, United States of America.
Li X; Division of Infectious Diseases, Department of Pediatrics, University of Florida, Gainesville, FL, United States of America.
Spadaro SV; Division of Infectious Diseases, Department of Pediatrics, Stony Brook University, Stony Brook, NY, United States of America.
Brantly AC; Division of Infectious Diseases, Department of Pediatrics, University of Florida, Gainesville, FL, United States of America.
Ayers JB; Division of Infectious Diseases, Department of Pediatrics, Stony Brook University, Stony Brook, NY, United States of America.
Perez RD; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, United States of America.
Burton EM; Division of Infectious Diseases, Department of Pediatrics, University of Florida, Gainesville, FL, United States of America.
Burgula S; Division of Infectious Diseases, Department of Pediatrics, Stony Brook University, Stony Brook, NY, United States of America.
MacCarthy T; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, United States of America.
Bhaduri-McIntosh S; Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL, United States of America.; Division of Infectious Diseases, Department of Pediatrics, University of Florida, Gainesville, FL, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Oct 01; Vol. 16 (10), pp. e1008849. Date of Electronic Publication: 2020 Oct 01 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
Recombinational DNA Repair*
B-Lymphocytes/*virology
BRCA1 Protein/*metabolism
BRCA2 Protein/*metabolism
Epstein-Barr Virus Infections/*virology
STAT3 Transcription Factor/*metabolism
Adolescent ; Adult ; B-Lymphocytes/cytology ; B-Lymphocytes/metabolism ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Burkitt Lymphoma/genetics ; Burkitt Lymphoma/pathology ; Burkitt Lymphoma/virology ; Cell Proliferation ; DNA End-Joining Repair ; Epstein-Barr Virus Infections/genetics ; Epstein-Barr Virus Infections/metabolism ; Herpesvirus 4, Human/isolation & purification ; Humans ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/virology ; Phosphorylation ; STAT3 Transcription Factor/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury.
Autorzy :
Paris AJ; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hayer KE; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Oved JH; Division of Hematology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Avgousti DC; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Toulmin SA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Zepp JA; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Zacharias WJ; Division of Pulmonary Biology, Perinatal Institute, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Katzen JB; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Basil MC; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kremp MM; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Slamowitz AR; Department of Pediatrics, Children's National, Washington, DC, USA.
Jayachandran S; Division of Cardiology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sivakumar A; Division of Cardiology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Dai N; Division of Neonatology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Wang P; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Frank DB; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Cardiology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Eisenlohr LC; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Protective Immunity, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Cantu E 3rd; Division of Cardiovascular Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Beers MF; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Weitzman MD; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Protective Immunity, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Morrisey EE; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Institute for Regenerative Medicine, Perelman School of Medicine, Philadelphia, PA, USA.; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Worthen GS; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. .; Division of Neonatology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. .
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Źródło :
Nature cell biology [Nat Cell Biol] 2020 Oct; Vol. 22 (10), pp. 1197-1210. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Regeneration*
Alveolar Epithelial Cells/*cytology
Brain-Derived Neurotrophic Factor/*metabolism
Lung Injury/*prevention & control
Membrane Glycoproteins/*metabolism
Protein-Tyrosine Kinases/*metabolism
Receptor, trkB/*metabolism
STAT3 Transcription Factor/*metabolism
Alveolar Epithelial Cells/metabolism ; Animals ; Brain-Derived Neurotrophic Factor/genetics ; Female ; Humans ; Lung Injury/etiology ; Lung Injury/pathology ; Male ; Membrane Glycoproteins/genetics ; Protein-Tyrosine Kinases/genetics ; Receptor, trkB/genetics ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
Effect of NMO-IgG on the interleukin-6 cascade in astrocytes via activation of the JAK/STAT3 signaling pathway.
Autorzy :
Du L; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China.
Chang H; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China.
Xu W; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China.
Wei Y; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China.
Wang Y; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China.
Yin L; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China. Electronic address: .
Zhang X; Department of Neurology, Beijing Tiantan Hospital; China National Clinical Research Center for Neurological Diseases; Advanced Innovation Center for Human Brain Protection, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Oct 01; Vol. 258, pp. 118217. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article
MeSH Terms :
Astrocytes/*metabolism
Immunoglobulin G/*blood
Interleukin-6/*metabolism
Janus Kinases/*metabolism
Neuromyelitis Optica/*blood
STAT3 Transcription Factor/*metabolism
Adult ; Aged ; Animals ; Astrocytes/drug effects ; Autoantibodies/blood ; Autoantibodies/pharmacology ; Cells, Cultured ; Female ; Humans ; Immunoglobulin G/pharmacology ; Interleukin-6/agonists ; Male ; Middle Aged ; Rats ; Rats, Wistar ; STAT3 Transcription Factor/agonists ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Young Adult
Czasopismo naukowe
Tytuł :
The long non-coding RNA LINC00473 contributes to cell proliferation via JAK-STAT3 signaling pathway by regulating miR-195-5p/SEPT2 axis in prostate cancer.
Autorzy :
Xing Z; Department of Urology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, No.43, Renmin Road, Meilan District, Haikou, 570208, Hainan Province, P.R. China.
Li S; Department of Gastroenterology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou 570208, Hainan Province, P.R. China.
Liu Z; Department of Urology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, No.43, Renmin Road, Meilan District, Haikou, 570208, Hainan Province, P.R. China.
Zhang C; Department of Urology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, No.43, Renmin Road, Meilan District, Haikou, 570208, Hainan Province, P.R. China.
Meng M; Department of Urology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, No.43, Renmin Road, Meilan District, Haikou, 570208, Hainan Province, P.R. China.
Bai Z; Department of Urology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, No.43, Renmin Road, Meilan District, Haikou, 570208, Hainan Province, P.R. China.
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Źródło :
Bioscience reports [Biosci Rep] 2020 Sep 30; Vol. 40 (9).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
MicroRNAs/*metabolism
Prostatic Neoplasms/*pathology
RNA, Long Noncoding/*genetics
STAT3 Transcription Factor/*genetics
Septins/*genetics
Cell Line, Tumor ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Janus Kinases/genetics ; Janus Kinases/metabolism ; Male ; MicroRNAs/genetics ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; RNA, Long Noncoding/metabolism ; STAT3 Transcription Factor/metabolism ; Septins/metabolism
Czasopismo naukowe

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