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Tytuł :
Converging purinergic and immune signaling pathways drive IL-6 secretion by Fragile X cortical astrocytes via STAT3.
Autorzy :
Reynolds KE; Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada.
Krasovska V; Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada.
Scott AL; Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada. Electronic address: .
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Źródło :
Journal of neuroimmunology [J Neuroimmunol] 2021 Dec 15; Vol. 361, pp. 577745. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*metabolism
Fragile X Syndrome/*metabolism
Interleukin-6/*metabolism
Purinergic P2Y Receptor Agonists/*pharmacology
STAT3 Transcription Factor/*physiology
Signal Transduction/*physiology
Tenascin/*metabolism
Uridine Triphosphate/*pharmacology
Animals ; Cells, Cultured ; Disease Models, Animal ; Fragile X Mental Retardation Protein/genetics ; Male ; Mice ; Mice, Knockout ; Phosphorylation ; Phosphotyrosine/metabolism ; Protein Processing, Post-Translational ; RNA Interference ; RNA, Small Interfering/genetics ; RNA, Small Interfering/pharmacology ; Receptors, Interleukin-6/biosynthesis ; Receptors, Interleukin-6/genetics ; STAT3 Transcription Factor/antagonists & inhibitors ; STAT3 Transcription Factor/genetics ; Signal Transduction/immunology ; Sulfonamides/pharmacology ; Toll-Like Receptor 4/antagonists & inhibitors ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
MiR-125b enhances autophagic flux to improve septic cardiomyopathy via targeting STAT3/HMGB1.
Autorzy :
Yu Y; Liver Disease Center, Hunan Children's Hospital, Changsha, 410007, Hunan Province, PR China.
Ou-Yang WX; Liver Disease Center, Hunan Children's Hospital, Changsha, 410007, Hunan Province, PR China.
Zhang H; Liver Disease Center, Hunan Children's Hospital, Changsha, 410007, Hunan Province, PR China.
Jiang T; Liver Disease Center, Hunan Children's Hospital, Changsha, 410007, Hunan Province, PR China.
Tang L; Liver Disease Center, Hunan Children's Hospital, Changsha, 410007, Hunan Province, PR China.
Tan YF; Liver Disease Center, Hunan Children's Hospital, Changsha, 410007, Hunan Province, PR China.
Luo HY; Liver Disease Center, Hunan Children's Hospital, Changsha, 410007, Hunan Province, PR China.
Xiao ZH; Emergence Center, Hunan Children's Hospital, Changsha, 410007, Hunan Province, PR China.
Li SJ; Liver Disease Center, Hunan Children's Hospital, Changsha, 410007, Hunan Province, PR China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2021 Dec 15; Vol. 409 (2), pp. 112842. Date of Electronic Publication: 2021 Sep 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy*
Cardiomyopathies/*prevention & control
HMGB1 Protein/*antagonists & inhibitors
MicroRNAs/*genetics
STAT3 Transcription Factor/*antagonists & inhibitors
Sepsis/*complications
Animals ; Apoptosis ; Cardiomyopathies/etiology ; Cardiomyopathies/metabolism ; Cardiomyopathies/pathology ; Cell Proliferation ; HMGB1 Protein/genetics ; HMGB1 Protein/metabolism ; Mice ; Rats ; Rats, Sprague-Dawley ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
PLXNA2 knockdown promotes M2 microglia polarization through mTOR/STAT3 signaling to improve functional recovery in rats after cerebral ischemia/reperfusion injury.
Autorzy :
Li S; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Hua X; Department of Traumatology and Orthopedics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Zheng M; Department of Traumatology and Orthopedics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Wu J; Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Ma Z; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Xing X; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Ma J; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zhang J; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Shan C; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China; Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai 201203, China.
Xu J; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai 201203, China. Electronic address: .
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Źródło :
Experimental neurology [Exp Neurol] 2021 Dec; Vol. 346, pp. 113854. Date of Electronic Publication: 2021 Aug 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Ischemia/*metabolism
Microglia/*metabolism
Nerve Tissue Proteins/*deficiency
Receptors, Cell Surface/*deficiency
Reperfusion Injury/*metabolism
STAT3 Transcription Factor/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Animals ; Brain Ischemia/genetics ; Brain Ischemia/pathology ; Gait Analysis/methods ; Gene Knockdown Techniques/methods ; Male ; Maze Learning/physiology ; Microglia/pathology ; Nerve Tissue Proteins/antagonists & inhibitors ; Nerve Tissue Proteins/genetics ; Rats ; Rats, Sprague-Dawley ; Receptors, Cell Surface/antagonists & inhibitors ; Receptors, Cell Surface/genetics ; Recovery of Function/physiology ; Reperfusion Injury/genetics ; Reperfusion Injury/pathology ; STAT3 Transcription Factor/antagonists & inhibitors ; STAT3 Transcription Factor/genetics ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/genetics
Czasopismo naukowe
Tytuł :
Circular RNA hsa_circ_0000117 accelerates the proliferation and invasion of gastric cancer cells by regulating the microRNA-337-3p/signal transducer and activator of transcription 3 axis.
Autorzy :
Gao Q; Department of Anesthesia, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Liu Q; Department of Anesthesia, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Chen H; Department of Anesthesia, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 1381-1390.
Typ publikacji :
Journal Article
MeSH Terms :
MicroRNAs*/genetics
MicroRNAs*/metabolism
RNA, Circular*/genetics
RNA, Circular*/metabolism
STAT3 Transcription Factor*/genetics
STAT3 Transcription Factor*/metabolism
Stomach Neoplasms/*pathology
Cell Line, Tumor ; Cell Proliferation/genetics ; Humans ; Neoplasm Invasiveness/genetics ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis.
Autorzy :
Zhou S; Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Science, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Disease, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Dai Q; 2nd Dental Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Disease, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Huang X; Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Science, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Disease, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Jin A; Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Science, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Disease, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Yang Y; Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Science, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Disease, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Gong X; Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Science, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Disease, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Xu H; Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Science, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Disease, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Gao X; Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Science, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Disease, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Jiang L; Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Science, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Disease, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Nov 25; Vol. 12 (1), pp. 6891. Date of Electronic Publication: 2021 Nov 25.
Typ publikacji :
Journal Article
MeSH Terms :
Osteogenesis/*genetics
STAT3 Transcription Factor/*metabolism
Animals ; Bone Development/genetics ; Bone Remodeling/genetics ; Cell Differentiation/drug effects ; Homeodomain Proteins/genetics ; Homeostasis/drug effects ; Homeostasis/genetics ; MSX1 Transcription Factor/genetics ; MSX1 Transcription Factor/metabolism ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Mice ; Musculoskeletal Abnormalities/drug therapy ; Musculoskeletal Abnormalities/genetics ; Musculoskeletal Abnormalities/metabolism ; Osteoblasts/cytology ; Osteoblasts/metabolism ; Osteogenesis/drug effects ; STAT3 Transcription Factor/antagonists & inhibitors ; STAT3 Transcription Factor/genetics ; Signal Transduction ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Essential Role of STAT3 Signaling in Hair Follicle Homeostasis.
Autorzy :
Miyauchi K; Laboratory for Cytokine Regulation, Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Yokohama, Japan.
Ki S; Laboratory for Cytokine Regulation, Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Yokohama, Japan.
Ukai M; Laboratory for Integrated Cellular Systems, Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Yokohama, Japan.; Graduate School of Medical Life Sciences, Yokohama City University, Yokohama, Japan.
Suzuki Y; Laboratory for Cytokine Regulation, Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Yokohama, Japan.
Inoue K; Laboratory for Integrated Cellular Systems, Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Yokohama, Japan.; Department of Computer Science and Systems Engineering, Faculty of Engineering, University of Miyazaki, Miyazaki-shi, Japan.
Suda W; Laboratory for Microbiome science, Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Yokohama, Japan.; Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.
Matsui T; Laboratory for Evolutionary Cell Biology of the Skin, School of Bioscience and Biotechnology, Tokyo University of Technology, Hachioji, Japan.
Ito Y; Laboratory for Gut Homeostasis, Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Yokohama, Japan.
Honda K; Laboratory for Gut Homeostasis, Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Yokohama, Japan.; Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Koseki H; Disease Biology Group, RIKEN Medical Sciences Innovation Hub Program, Kanagawa, Japan.; Laboratory for Developmental Genetics, Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Yokohama, Japan.
Ohara O; Laboratory for Integrative Genomics, Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Yokohama, Japan.; Department of Applied Genomics, Kazusa DNA Research Institute, Kisarazu, Japan.
Tanaka RJ; Department of Bioengineering, Imperial College London, London, United Kingdom.
Okada-Hatakeyama M; Laboratory for Integrated Cellular Systems, Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Yokohama, Japan.; Graduate School of Medical Life Sciences, Yokohama City University, Yokohama, Japan.; Institute for Protein Research, Osaka University, Suita-shi, Japan.
Kubo M; Laboratory for Cytokine Regulation, Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, Yokohama, Japan.; Division of Molecular Pathology, Research Institute for Biomedical Science, Tokyo University of Science, Noda-shi, Japan.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Nov 11; Vol. 12, pp. 663177. Date of Electronic Publication: 2021 Nov 11 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Hair Follicle/*physiology
STAT3 Transcription Factor/*physiology
Animals ; Dermatitis, Atopic/etiology ; Dermatitis, Atopic/genetics ; Dermatitis, Atopic/immunology ; Disease Models, Animal ; Female ; Gene Expression Regulation ; Hair Follicle/immunology ; Homeostasis ; Humans ; Keratinocytes/immunology ; Keratinocytes/physiology ; Keratins/genetics ; Male ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Knockout ; STAT3 Transcription Factor/deficiency ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/immunology ; Signal Transduction ; Skin/immunology ; Skin/microbiology ; Skin Physiological Phenomena ; Th17 Cells/immunology
Czasopismo naukowe
Tytuł :
The anti-parallel dimer binding interface in STAT3 transcription factor is required for the inactivation of cytokine-mediated signal transduction.
Autorzy :
Menon PR; Department of Psychosomatic Medicine and Psychotherapy, University Medical Centre Göttingen, German Centre for Cardiovascular Research (DZHK), partner site Göttingen, Germany.
Doudin A; Department of Psychosomatic Medicine and Psychotherapy, University Medical Centre Göttingen, German Centre for Cardiovascular Research (DZHK), partner site Göttingen, Germany.
Gregus A; Department of Psychosomatic Medicine and Psychotherapy, University Medical Centre Göttingen, German Centre for Cardiovascular Research (DZHK), partner site Göttingen, Germany.
Wirths O; Department of Psychiatry and Psychotherapy, University Medical Centre Göttingen, Germany.
Staab J; Department of Psychosomatic Medicine and Psychotherapy, University Medical Centre Göttingen, German Centre for Cardiovascular Research (DZHK), partner site Göttingen, Germany.
Meyer T; Department of Psychosomatic Medicine and Psychotherapy, University Medical Centre Göttingen, German Centre for Cardiovascular Research (DZHK), partner site Göttingen, Germany. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2021 Nov; Vol. 1868 (12), pp. 119118. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
STAT3 Transcription Factor/*chemistry
Animals ; Binding Sites ; Cell Line, Tumor ; Cytokines/metabolism ; Humans ; Janus Kinase 2/metabolism ; Mice ; Mutation, Missense ; Protein Binding ; Protein Multimerization ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/metabolism ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
STAT3 mediated regulation of glucose metabolism in leukemia cells.
Autorzy :
Yucel B; Istanbul Medeniyet University, Medical Faculty, Department of Medical Biology, Istanbul, Turkey; Istanbul Medeniyet University, Science and Advanced Technologies Research Center (BILTAM), Istanbul, Turkey; Health Institutes of Turkey (TUSEB), Turkish Biotechnology Institute, Istanbul, Turkey. Electronic address: .
Altundağ Kara S; Istanbul Medeniyet University, Medical Faculty, Department of Medical Biochemistry, Istanbul, Turkey.
Cekmen MB; Istanbul Medeniyet University, Medical Faculty, Department of Medical Biochemistry, Istanbul, Turkey.
Ada S; Istanbul Medeniyet University, Medical Faculty, Department of Medical Biochemistry, Istanbul, Turkey; Istanbul Medeniyet University, Science and Advanced Technologies Research Center (BILTAM), Istanbul, Turkey.
Demircan Tan B; Istanbul Medeniyet University, Medical Faculty, Department of Medical Biology, Istanbul, Turkey.
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Źródło :
Gene [Gene] 2022 Jan 30; Vol. 809, pp. 146012. Date of Electronic Publication: 2021 Oct 13.
Typ publikacji :
Journal Article
MeSH Terms :
Glucose/*metabolism
Leukemia/*metabolism
STAT3 Transcription Factor/*metabolism
Cell Line, Tumor ; Cell Proliferation ; Culture Media/chemistry ; Down-Regulation ; Gene Expression Regulation, Leukemic ; Glucose Transporter Type 3/metabolism ; Glycolysis/physiology ; HL-60 Cells ; Humans ; K562 Cells ; Leukemia/genetics ; Leukemia/pathology ; Mitochondria/metabolism ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
Interleukin-9 attenuates inflammatory response and hepatocyte apoptosis in alcoholic liver injury.
Autorzy :
Meng H; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, China; The Key laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China.
Niu R; Department of pharmacy, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
You H; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, China; The Key laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China.
Wang L; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, China; The Key laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China.
Feng R; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, China; The Key laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China.
Huang C; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, China; The Key laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China. Electronic address: .
Li J; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, China; The Key laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2022 Jan 01; Vol. 288, pp. 120180. Date of Electronic Publication: 2021 Nov 26.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Chemical and Drug Induced Liver Injury/*prevention & control
Ethanol/*toxicity
Hepatocytes/*pathology
Interleukin-9/*metabolism
Macrophages/*immunology
STAT3 Transcription Factor/*metabolism
Animals ; Central Nervous System Depressants/toxicity ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Hepatocytes/immunology ; Hepatocytes/metabolism ; Interleukin-9/genetics ; Macrophages/metabolism ; Macrophages/pathology ; Male ; Mice ; Mice, Inbred C57BL ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
BRD4 Regulates Transcription Factor ΔNp63α to Drive a Cancer Stem Cell Phenotype in Squamous Cell Carcinomas.
Autorzy :
Fisher ML; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Balinth S; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.; Molecular and Cellular Biology Program, Stony Brook University, Stony Brook, New York.
Hwangbo Y; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Wu C; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Ballon C; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Wilkinson JE; Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.
Goldberg GL; Zucker School of Medicine, Hofstra University/Northwell Health, Hempstead, New York.
Mills AA; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. .
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Źródło :
Cancer research [Cancer Res] 2021 Dec 15; Vol. 81 (24), pp. 6246-6258. Date of Electronic Publication: 2021 Oct 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Carcinoma, Squamous Cell/*pathology
Cell Cycle Proteins/*metabolism
Enhancer of Zeste Homolog 2 Protein/*metabolism
Neoplastic Stem Cells/*pathology
STAT3 Transcription Factor/*metabolism
Transcription Factors/*metabolism
Tumor Suppressor Proteins/*metabolism
Animals ; Apoptosis ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism ; Cell Cycle Proteins/genetics ; Cell Proliferation ; Enhancer of Zeste Homolog 2 Protein/genetics ; Humans ; Mice ; Mice, Nude ; Neoplastic Stem Cells/metabolism ; STAT3 Transcription Factor/genetics ; Transcription Factors/genetics ; Tumor Cells, Cultured ; Tumor Suppressor Proteins/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Tumor necrosis factor-α induced protein 8 (TNFAIP8/TIPE) family is differentially expressed in oral cancer and regulates tumorigenesis through Akt/mTOR/STAT3 signaling cascade.
Autorzy :
Padmavathi G; Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India.
Monisha J; Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India.
Bordoloi D; Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India.
Banik K; Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India.
Roy NK; Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India.
Girisa S; Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India.
Singh AK; Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India.
Longkumer I; North-East Cancer Hospital and Research Institute, Guwahati 781023, Assam, India.
Baruah MN; North-East Cancer Hospital and Research Institute, Guwahati 781023, Assam, India.
Kunnumakkara AB; Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Dec 15; Vol. 287, pp. 120118. Date of Electronic Publication: 2021 Nov 02.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis Regulatory Proteins/*biosynthesis
Carcinogenesis/*metabolism
Mouth Neoplasms/*metabolism
Proto-Oncogene Proteins c-akt/*biosynthesis
STAT3 Transcription Factor/*biosynthesis
TOR Serine-Threonine Kinases/*biosynthesis
Apoptosis Regulatory Proteins/genetics ; Carcinogenesis/chemically induced ; Carcinogenesis/genetics ; Carcinogens/toxicity ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Expression Regulation, Neoplastic/physiology ; Gene Knockout Techniques/methods ; Humans ; Intracellular Signaling Peptides and Proteins/biosynthesis ; Intracellular Signaling Peptides and Proteins/genetics ; Mouth Neoplasms/genetics ; Proto-Oncogene Proteins c-akt/genetics ; STAT3 Transcription Factor/genetics ; Signal Transduction/drug effects ; Signal Transduction/physiology ; TOR Serine-Threonine Kinases/genetics ; Tobacco/toxicity
Czasopismo naukowe
Tytuł :
LncRNA HOTTIP from synovial fibroblast-derived exosomes: A novel molecular target for rheumatoid arthritis through the miR-1908-5p/STAT3 axis.
Autorzy :
Yao X; Department of Rheumatology and Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Fei Shan Street, Guiyang 550003, China.
Wang Q; Department of Rheumatology and Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Fei Shan Street, Guiyang 550003, China.
Zeng P; Department of Rheumatology and Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Fei Shan Street, Guiyang 550003, China.
Hou L; Department of Rheumatology and Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Fei Shan Street, Guiyang 550003, China.
Yang Y; Department of Rheumatology and Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Fei Shan Street, Guiyang 550003, China.
Lu D; Department of Rheumatology and Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Fei Shan Street, Guiyang 550003, China.
Huang Y; Department of Rheumatology and Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Fei Shan Street, Guiyang 550003, China.
Ning Q; Department of Rheumatology and Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Fei Shan Street, Guiyang 550003, China.
Xu H; Department of Rheumatology and Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Fei Shan Street, Guiyang 550003, China.
Cao Y; Department of Rheumatology and Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Fei Shan Street, Guiyang 550003, China.
Tang F; Department of Rheumatology and Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Fei Shan Street, Guiyang 550003, China.
An Y; Department of Rheumatology and Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Fei Shan Street, Guiyang 550003, China.
Zhou J; Department of Rheumatology and Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Fei Shan Street, Guiyang 550003, China.
Huang W; Department of Orthopedics, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Fei Shan Street, Guiyang 550003, China. Electronic address: .
Ma W; Department of Rheumatology and Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Fei Shan Street, Guiyang 550003, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2021 Dec 15; Vol. 409 (2), pp. 112943. Date of Electronic Publication: 2021 Nov 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arthritis, Experimental/*pathology
Arthritis, Rheumatoid/*pathology
Exosomes/*genetics
MicroRNAs/*genetics
RNA, Long Noncoding/*genetics
STAT3 Transcription Factor/*metabolism
Synoviocytes/*metabolism
Animals ; Apoptosis ; Arthritis, Experimental/etiology ; Arthritis, Experimental/metabolism ; Arthritis, Rheumatoid/etiology ; Arthritis, Rheumatoid/metabolism ; Cell Proliferation ; Cells, Cultured ; Cytokines/metabolism ; Disease Models, Animal ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Mice ; STAT3 Transcription Factor/genetics ; Synoviocytes/pathology
Czasopismo naukowe
Tytuł :
Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition.
Autorzy :
Oleksak P; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Psotka M; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Vancurova M; Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Sapega O; Laboratory of Immunological and Tumour Models, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Bieblova J; Laboratory of Immunological and Tumour Models, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Reinis M; Laboratory of Immunological and Tumour Models, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Rysanek D; Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Mikyskova R; Laboratory of Immunological and Tumour Models, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Chalupova K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Malinak D; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Svobodova J; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Andrys R; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Rehulkova H; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Skopek V; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Ngoc Lam P; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Bartek J; Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.; Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.
Hodny Z; Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Musilek K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 410-424.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Aminosalicylic Acids/*pharmacology
Antineoplastic Agents/*pharmacology
STAT3 Transcription Factor/*antagonists & inhibitors
Sulfonamides/*pharmacology
Aminosalicylic Acids/chemical synthesis ; Aminosalicylic Acids/chemistry ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Humans ; Hydrophobic and Hydrophilic Interactions ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; Phosphorylation/drug effects ; STAT3 Transcription Factor/metabolism ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry
Czasopismo naukowe
Tytuł :
Long non-coding RNA TINCR promotes hepatocellular carcinoma proliferation and invasion via STAT3 signaling by direct interacting with T-cell protein tyrosine phosphatase (TCPTP).
Autorzy :
Tang C; Department of General Surgery, The First People's Hospital Affiliated to Huzhou Normal College, Huzhou, Zhejiang, People's Republic of China.
Feng W; Department of General Surgery, The First People's Hospital Affiliated to Huzhou Normal College, Huzhou, Zhejiang, People's Republic of China.
Bao Y; Department of General Surgery, The First People's Hospital Affiliated to Huzhou Normal College, Huzhou, Zhejiang, People's Republic of China.
Du H; Out-Patient Department, The First People's Hospital Affiliated to Huzhou Normal College, Huzhou, Zhejiang, People's Republic of China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 2119-2131.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/metabolism
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/genetics
Liver Neoplasms*/metabolism
Liver Neoplasms*/pathology
Protein Tyrosine Phosphatase, Non-Receptor Type 2/*genetics
RNA, Long Noncoding/*genetics
STAT3 Transcription Factor/*genetics
Cell Line, Tumor ; Gene Knockdown Techniques ; Humans ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/metabolism ; RNA, Long Noncoding/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Ozone protects cardiomyocytes against ischemia/reperfusion injury: Regulating the heat shock protein 70 (HPS70) expression through activating the JAK2/STAT3 Pathway.
Autorzy :
Yu S; The first clinical college of Jinan University, Guangzhou, China.; Department of Cardiovascular, Panyu Central Hospital, (Cardiovascular Institute of Panyu District), Guangzhou, China.
Guo H; Department of Radiology, Panyu Central Hospital, (Medical Imaging Institute of Panyu District), Guangzhou, China.
Luo Y; The first clinical college of Jinan University, Guangzhou, China.; Department of Cardiovascular Medicine, First People's Hospital, Guangzhou, China.
Chen H; The first clinical college of Jinan University, Guangzhou, China.; Department of Radiology, Panyu Central Hospital, (Medical Imaging Institute of Panyu District), Guangzhou, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 6606-6616.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HSP70 Heat-Shock Proteins/*genetics
Janus Kinase 2/*genetics
Myocardial Reperfusion Injury/*metabolism
Ozone/*pharmacology
STAT3 Transcription Factor/*genetics
Animals ; Cells, Cultured ; HSP70 Heat-Shock Proteins/metabolism ; Heart/drug effects ; Janus Kinase 2/metabolism ; Male ; Myocardial Infarction/metabolism ; Myocardium/metabolism ; Myocytes, Cardiac/drug effects ; Protective Agents/pharmacology ; Rats ; Rats, Sprague-Dawley ; STAT3 Transcription Factor/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
STAT3 activation in large granular lymphocyte leukemia is associated with cytokine signaling and DNA hypermethylation.
Autorzy :
Kim D; Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
Park G; Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
Huuhtanen J; Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
Ghimire B; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Rajala H; Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
Moriggl R; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.
Chan WC; Department of Pathology, City of Hope National Medical Center, Duarte, CA, USA.
Kankainen M; Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.; Department of Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland.
Myllymäki M; Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
Mustjoki S; Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland. .; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland. .; iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland. .
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Źródło :
Leukemia [Leukemia] 2021 Dec; Vol. 35 (12), pp. 3430-3443. Date of Electronic Publication: 2021 Jun 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Gene Expression Regulation, Neoplastic*
Mutation*
Biomarkers, Tumor/*genetics
Cytokines/*metabolism
Leukemia, Large Granular Lymphocytic/*pathology
STAT3 Transcription Factor/*metabolism
Humans ; Killer Cells, Natural/metabolism ; Leukemia, Large Granular Lymphocytic/genetics ; Leukemia, Large Granular Lymphocytic/metabolism ; STAT3 Transcription Factor/genetics ; Signal Transduction ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Early-onset, fatal interstitial lung disease in STAT3 gain-of-function patients.
Autorzy :
Gothe F; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany.
Gehrig J; Center for Chronic Immunodeficiency, Medical Center, Institute for Immunodeficiency, University of Freiburg, Freiburg, Germany.
Rapp CK; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany.
Knoflach K; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany.
Reu-Hofer S; Department of Pathology, Julius-Maximilians-Universität Wuerzburg, Wuerzburg, Germany.
Länger F; Department of Pathology, Hannover Medical School, Hanover, Germany.; German Center for Lung Research (DZL), BREATH Hannover, Hanover, Germany.
Schramm D; Department of Pediatric Pneumology, University Children's Hospital Düsseldorf, Düsseldorf, Germany.
Ley-Zaporozhan J; Department of Radiology, Pediatric Radiology, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany.
Ehl S; Center for Chronic Immunodeficiency, Medical Center, Institute for Immunodeficiency, University of Freiburg, Freiburg, Germany.; Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany.
Schwerk N; German Center for Lung Research (DZL), BREATH Hannover, Hanover, Germany.; Department of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Hanover, Germany.
Faletti L; Center for Chronic Immunodeficiency, Medical Center, Institute for Immunodeficiency, University of Freiburg, Freiburg, Germany.; Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany.
Griese M; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany.; German Center for Lung Research (DZL), CPC Munich, Munich, Germany.
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Źródło :
Pediatric pulmonology [Pediatr Pulmonol] 2021 Dec; Vol. 56 (12), pp. 3934-3941. Date of Electronic Publication: 2021 Sep 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gain of Function Mutation*
Lung Diseases, Interstitial*/diagnosis
Lung Diseases, Interstitial*/genetics
STAT3 Transcription Factor*/genetics
Age of Onset ; Autoimmunity ; Child, Preschool ; Humans ; Infant ; Infant, Newborn ; Lung/diagnostic imaging ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
Long non-coding RNA LINC00511 regulates the expression of microRNA-625-5p and activates signal transducers and activators of transcription 3 (STAT3) to accelerate the progression of gastric cancer.
Autorzy :
Cui N; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Sun Q; Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
Liu H; Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
Li L; Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
Guo X; Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
Shi Y; Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
Jing C; Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
Qin C; Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
Zhao Y; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 2915-2927.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Stomach Neoplasms*/genetics
Stomach Neoplasms*/metabolism
Stomach Neoplasms*/pathology
MicroRNAs/*genetics
RNA, Long Noncoding/*genetics
STAT3 Transcription Factor/*genetics
Animals ; Cell Line, Tumor ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Mice ; Mice, Nude ; MicroRNAs/metabolism ; RNA, Long Noncoding/metabolism ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
Pseudopodium enriched atypical kinase 1(PEAK1) promotes invasion and of melanoma cells by activating JAK/STAT3 signals.
Autorzy :
Pan M; Department of Dermatology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Yin X; Department of Dermatology, Qingdao Women and Children's Hospital, Qingdao, China.
Huang YC; Department of Otolaryngology, The Affiliated Hospital of Qingdao University, Qingdao, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 5045-5055.
Typ publikacji :
Journal Article
MeSH Terms :
Melanoma*/genetics
Melanoma*/metabolism
Melanoma*/pathology
Protein-Tyrosine Kinases*/genetics
Protein-Tyrosine Kinases*/metabolism
Janus Kinases/*genetics
STAT3 Transcription Factor/*genetics
Animals ; Cell Line, Tumor ; Female ; Humans ; Janus Kinases/metabolism ; Mice ; Mice, Nude ; Neoplasm Invasiveness/genetics ; Neoplasm Metastasis/genetics ; STAT3 Transcription Factor/metabolism ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Long non-coding RNA VCAN-AS1 promotes the malignant behaviors of breast cancer by regulating the miR-106a-5p-mediated STAT3/HIF-1α pathway.
Autorzy :
Du P; Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Luo K; Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Li G; Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Zhu J; Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Xiao Q; Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Li Y; Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Zhang X; Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 5028-5044.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms*/genetics
Breast Neoplasms*/metabolism
Breast Neoplasms*/pathology
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
MicroRNAs/*metabolism
RNA, Long Noncoding/*genetics
STAT3 Transcription Factor/*metabolism
Breast/metabolism ; Breast/pathology ; Cell Line, Tumor ; Female ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; MicroRNAs/genetics ; Middle Aged ; RNA, Long Noncoding/metabolism ; STAT3 Transcription Factor/genetics ; Signal Transduction/genetics
Czasopismo naukowe

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