- Tytuł:
- Oligomeric proanthocyanidins and epigallocatechin gallate aggravate autophagy of foam cells through the activation of Class III PI3K/Beclin1-complex mediated cholesterol efflux.
- Autorzy:
- Źródło:
- BioFactors (Oxford, England) [Biofactors] 2019 Sep; Vol. 45 (5), pp. 763-773. Date of Electronic Publication: 2019 Jun 25.
- Typ publikacji:
- Journal Article
- MeSH Terms:
-
Beclin-1/*genetics
Catechin/*analogs & derivatives
Cholesterol/*metabolism
Class III Phosphatidylinositol 3-Kinases/*genetics
Foam Cells/*drug effects
Proanthocyanidins/*pharmacology
ATP Binding Cassette Transporter 1/genetics ; ATP Binding Cassette Transporter 1/metabolism ; Autophagy/drug effects ; Autophagy/genetics ; Autophagy-Related Protein 5/genetics ; Autophagy-Related Protein 5/metabolism ; Beclin-1/metabolism ; Catechin/pharmacology ; Chromones/pharmacology ; Class III Phosphatidylinositol 3-Kinases/antagonists & inhibitors ; Class III Phosphatidylinositol 3-Kinases/metabolism ; Enzyme Inhibitors/pharmacology ; Foam Cells/cytology ; Foam Cells/metabolism ; Gene Expression Regulation ; Humans ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Morpholines/pharmacology ; Phagosomes/drug effects ; Phagosomes/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; THP-1 Cells ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe