Autor: "Sakurada SM" - OpacWWW

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Tytuł:: The nonreceptor tyrosine kinase SRMS inhibits autophagy and promotes tumor growth by phosphorylating the scaffolding protein FKBP51.
Autorzy:: Park JM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.; Department of Oncology Research, Amgen Research, Thousand Oaks, California, United States of America.
Yang SW; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Zhuang W; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Bera AK; Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
Liu Y; Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
Gurbani D; Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
von Hoyningen-Huene SJ; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Sakurada SM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Gan H; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Pruett-Miller SM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Westover KD; Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
Potts MB; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.; Department of Oncology Research, Amgen Research, Thousand Oaks, California, United States of America.; Pokaż więcej
Źródło:: PLoS biology [PLoS Biol] 2021 Jun 02; Vol. 19 (6), pp. e3001281. Date of Electronic Publication: 2021 Jun 02 (Print Publication: 2021).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Autophagy*/drug effects
Neoplasms/*metabolism
Neoplasms/*pathology
Tacrolimus Binding Proteins/*metabolism
src-Family Kinases/*metabolism
Adenine/analogs & derivatives ; Adenine/pharmacology ; Animals ; Beclin-1/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cellular Senescence/drug effects ; Enzyme Activation/drug effects ; Mice ; Nuclear Proteins/metabolism ; Phosphoprotein Phosphatases/metabolism ; Phosphorylation/drug effects ; Phosphotyrosine/metabolism ; Piperidines/pharmacology ; Protein Binding/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; src-Family Kinases/antagonists & inhibitors

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