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Tytuł :
Oxytocin-MCH circuit regulates monosynaptic inputs to MCH neurons and modulates social recognition memory.
Autorzy :
Sanathara N; Departments of Pharmaceutical Sciences, School of Pharmacy, University of California-Irvine, CA, 92697, USA.
Alhassen L; Departments of Pharmaceutical Sciences, School of Pharmacy, University of California-Irvine, CA, 92697, USA.
Marmouzi I; Departments of Pharmaceutical Sciences, School of Pharmacy, University of California-Irvine, CA, 92697, USA.
Khoudari M; Departments of Pharmaceutical Sciences, School of Pharmacy, University of California-Irvine, CA, 92697, USA.
Phan J; Departments of Pharmaceutical Sciences, School of Pharmacy, University of California-Irvine, CA, 92697, USA.
Alhassen W; Departments of Pharmaceutical Sciences, School of Pharmacy, University of California-Irvine, CA, 92697, USA.
Civelli O; Departments of Pharmaceutical Sciences, School of Pharmacy, University of California-Irvine, CA, 92697, USA; Department of Developmental and Cell Biology, School of Biological Sciences, University of California-Irvine, CA, 92697, USA.
Alachkar A; Departments of Pharmaceutical Sciences, School of Pharmacy, University of California-Irvine, CA, 92697, USA; Institute for Genomics and Bioinformatics, School of Information and Computer Sciences, University of California-Irvine, CA, 92697, USA. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2021 Feb 15; Vol. 184, pp. 108423. Date of Electronic Publication: 2020 Dec 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Mating and parenting experiences sculpture mood-modulating effects of oxytocin-MCH signaling.
Autorzy :
Phan J; Department of Pharmaceutical Sciences, University of California, Irvine, 356A Med Surge II, Irvine, CA, 92697-4625, USA.
Alhassen L; Department of Pharmaceutical Sciences, University of California, Irvine, 356A Med Surge II, Irvine, CA, 92697-4625, USA.
Argelagos A; Department of Pharmaceutical Sciences, University of California, Irvine, 356A Med Surge II, Irvine, CA, 92697-4625, USA.
Alhassen W; Department of Pharmaceutical Sciences, University of California, Irvine, 356A Med Surge II, Irvine, CA, 92697-4625, USA.
Vachirakorntong B; Department of Pharmaceutical Sciences, University of California, Irvine, 356A Med Surge II, Irvine, CA, 92697-4625, USA.
Lin Z; Department of Pharmaceutical Sciences, University of California, Irvine, 356A Med Surge II, Irvine, CA, 92697-4625, USA.
Sanathara N; Department of Pharmaceutical Sciences, University of California, Irvine, 356A Med Surge II, Irvine, CA, 92697-4625, USA.
Alachkar A; Department of Pharmaceutical Sciences, University of California, Irvine, 356A Med Surge II, Irvine, CA, 92697-4625, USA. .; Institute for Genomics and Bioinformatics, School of Information and Computer Sciences, University of California-Irvine, Irvine, CA, 92697, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Aug 12; Vol. 10 (1), pp. 13611. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Sexual Behavior, Animal*
Signal Transduction*
Depression/*psychology
Depression, Postpartum/*psychology
Postpartum Period/*psychology
Receptors, Oxytocin/*genetics
Affect ; Animals ; Depression/genetics ; Depression/metabolism ; Depression, Postpartum/genetics ; Depression, Postpartum/metabolism ; Disease Models, Animal ; Female ; Gene Deletion ; Hypothalamic Hormones/metabolism ; Male ; Maternal Behavior/psychology ; Melanins/metabolism ; Mice ; Oxytocin/metabolism ; Paternal Behavior/psychology ; Pituitary Hormones/metabolism ; Postpartum Period/genetics ; Postpartum Period/metabolism ; Sex Characteristics
Czasopismo naukowe
Tytuł :
Melanin Concentrating Hormone Signaling Deficits in Schizophrenia: Association With Memory and Social Impairments and Abnormal Sensorimotor Gating.
Autorzy :
Vawter MP; Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA.
Schulmann A; Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA.; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA.
Alhassen L; Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA.
Alhassen W; Department of Pharmacology, School of Medicine, University of California, Irvine, CA.; Department of Pharmaceutical Sciences, University of California, Irvine, CA.
Hamzeh AR; John Curtin School of Medical Research, Australian National University, Canberra.
Sakr J; Department of Pharmaceutical Sciences, University of California, Irvine, CA.
Pauluk L; Department of Pharmacology, School of Medicine, University of California, Irvine, CA.
Yoshimura R; Department of Pharmacology, School of Medicine, University of California, Irvine, CA.
Wang X; Department of Pharmacology, School of Medicine, University of California, Irvine, CA.
Dai Q; Department of Pharmacology, School of Medicine, University of California, Irvine, CA.
Sanathara N; Department of Pharmacology, School of Medicine, University of California, Irvine, CA.
Civelli O; Department of Pharmacology, School of Medicine, University of California, Irvine, CA.; Department of Pharmaceutical Sciences, University of California, Irvine, CA.; Department of Developmental and Cell Biology, School of Medicine, University of California, Irvine, CA.
Alachkar A; Department of Pharmaceutical Sciences, University of California, Irvine, CA.
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Źródło :
The international journal of neuropsychopharmacology [Int J Neuropsychopharmacol] 2020 Mar 10; Vol. 23 (1), pp. 53-65.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Hypothalamic Hormones/*metabolism
Melanins/*metabolism
Memory Disorders/*physiopathology
Pituitary Hormones/*metabolism
Prefrontal Cortex/*metabolism
Receptors, Somatostatin/*deficiency
Receptors, Somatostatin/*metabolism
Schizophrenia/*metabolism
Schizophrenia/*physiopathology
Sensory Gating/*physiology
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Behavior, Animal/physiology ; Child ; Child, Preschool ; Disease Models, Animal ; Female ; Fetus ; Humans ; Infant ; Male ; Memory Disorders/etiology ; Mice ; Mice, Knockout ; Middle Aged ; Schizophrenia/complications ; Young Adult
Czasopismo naukowe
Tytuł :
A Methionine-Induced Animal Model of Schizophrenia: Face and Predictive Validity
Autorzy :
Wang, L
Alachkar, A
Sanathara, N
Belluzzi, JD
Wang, Z
Civelli, O
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Temat :
Avoidance Learning
Psychology and Cognitive Sciences
Research Article
Recognition (Psychology)
Mental Health
Behavioral and Social Science
Recognition
Schizophrenia
Psychiatry
Antipsychotic Agents
Mice
Haloperidol
face validity
Brain Disorders
Psychology
Animals
2.1 Biological and endogenous factors
mouse model
Social Behavior
predictive validity
Schizophrenic Psychology
Disease Models
Treatment Outcome
Motor Activity
Medical and Health Sciences
Sensory Gating
methionine
Stereotyped Behavior
Animal
Clozapine
Depression
Pain Threshold
Male
Źródło :
International Journal of Neuropsychopharmacology, vol 18, iss 12
Wang, L; Alachkar, A; Sanathara, N; Belluzzi, JD; Wang, Z; & Civelli, O. (2015). A Methionine-Induced Animal Model of Schizophrenia: Face and Predictive Validity. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 18(12). doi: 10.1093/ijnp/pyv054. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/45m6s3qq
International Journal of Neuropsychopharmacology
Opis pliku :
application/pdf
Tytuł :
The role of Olfaction in MCH-regulated spontaneous maternal responses.
Autorzy :
Alhassen L; Department of Pharmacology, School of Medicine, 369 Med Surge II, University of California, Irvine, Irvine, CA 92697-4625, United States.
Phan A; Department of Pharmacology, School of Medicine, 369 Med Surge II, University of California, Irvine, Irvine, CA 92697-4625, United States.
Alhassen W; Department of Pharmacology, School of Medicine, 369 Med Surge II, University of California, Irvine, Irvine, CA 92697-4625, United States.
Nguyen P; Department of Pharmacology, School of Medicine, 369 Med Surge II, University of California, Irvine, Irvine, CA 92697-4625, United States.
Lo A; Department of Pharmacology, School of Medicine, 369 Med Surge II, University of California, Irvine, Irvine, CA 92697-4625, United States.
Shaharuddin H; Department of Pharmacology, School of Medicine, 369 Med Surge II, University of California, Irvine, Irvine, CA 92697-4625, United States.
Sanathara N; Department of Pharmacology, School of Medicine, 369 Med Surge II, University of California, Irvine, Irvine, CA 92697-4625, United States.
Civelli O; Department of Pharmacology, School of Medicine, 369 Med Surge II, University of California, Irvine, Irvine, CA 92697-4625, United States; Department of Pharmaceutical Sciences, School of Medicine, 369 Med Surge II, University of California, Irvine, Irvine, CA 92697-4625, United States; Department of Developmental and Cell Biology, School of Medicine, 369 Med Surge II, University of California, Irvine, Irvine, CA 92697-4625, United States.
Alachkar A; Department of Pharmaceutical Sciences, School of Medicine, 369 Med Surge II, University of California, Irvine, Irvine, CA 92697-4625, United States. Electronic address: .
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Źródło :
Brain research [Brain Res] 2019 Sep 15; Vol. 1719, pp. 71-76. Date of Electronic Publication: 2019 May 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Maternal Behavior/*physiology
Receptors, Somatostatin/*genetics
Smell/*genetics
Animals ; Behavior, Animal/physiology ; Female ; Germ-Line Mutation ; Hypothalamic Hormones/genetics ; Male ; Melanins/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neurons/metabolism ; Pituitary Hormones/genetics ; Receptors, Pituitary Hormone/genetics ; Receptors, Pituitary Hormone/metabolism ; Receptors, Somatostatin/metabolism ; Signal Transduction/physiology ; Smell/physiology
Czasopismo naukowe
Tytuł :
Inactivation of the melanin concentrating hormone system impairs maternal behavior.
Autorzy :
Alachkar A; Departments of Pharmacology, School of Medicine, University of California, 369 Med Surge II, Irvine, CA 92697-4625, United States. Electronic address: .
Alhassen L; Departments of Pharmacology, School of Medicine, University of California, 369 Med Surge II, Irvine, CA 92697-4625, United States.
Wang Z; Departments of Pharmacology, School of Medicine, University of California, 369 Med Surge II, Irvine, CA 92697-4625, United States.
Wang L; Departments of Pharmacology, School of Medicine, University of California, 369 Med Surge II, Irvine, CA 92697-4625, United States.
Onouye K; Departments of Pharmacology, School of Medicine, University of California, 369 Med Surge II, Irvine, CA 92697-4625, United States.
Sanathara N; Departments of Pharmacology, School of Medicine, University of California, 369 Med Surge II, Irvine, CA 92697-4625, United States.
Civelli O; Departments of Pharmacology, School of Medicine, University of California, 369 Med Surge II, Irvine, CA 92697-4625, United States; Pharmaceutical Sciences, School of Medicine, University of California, 369 Med Surge II, Irvine, CA 92697-4625, United States; Developmental and Cell Biology, School of Medicine, University of California, 369 Med Surge II, Irvine, CA 92697-4625, United States.
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Źródło :
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2016 Nov; Vol. 26 (11), pp. 1826-1835. Date of Electronic Publication: 2016 Sep 09.
Typ publikacji :
Journal Article
MeSH Terms :
Maternal Behavior/*drug effects
Receptors, Somatostatin/*genetics
Receptors, Somatostatin/*physiology
Aggression ; Animals ; Animals, Newborn ; Cannibalism/psychology ; Female ; Gene Expression Regulation/drug effects ; Genes, fos/drug effects ; Lactation/genetics ; Mice ; Mice, Knockout ; Nesting Behavior/drug effects ; Prolactin/biosynthesis ; Pyrimidinones/pharmacology ; Receptors, Somatostatin/antagonists & inhibitors ; Thiophenes/pharmacology
Czasopismo naukowe
Tytuł :
Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction.
Autorzy :
Alhassen, Sammy
Chen, Siwei
Alhassen, Lamees
Phan, Alvin
Khoudari, Mohammad
De Silva, Angele
Barhoosh, Huda
Wang, Zitong
Parrocha, Chelsea
Shapiro, Emily
Henrich, Charity
Wang, Zicheng
Mutesa, Leon
Baldi, Pierre
Abbott, Geoffrey W.
Alachkar, Amal
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Źródło :
Communications Biology. 6/24/2021, Vol. 4 Issue 1, p1-15. 15p.
Czasopismo naukowe
Tytuł :
Orphanin FQ-ORL-1 regulation of reproduction and reproductive behavior in the female.
Autorzy :
Sinchak K; Department of Biological Sciences, California State University, Long Beach, California, USA. Electronic address: .
Dalhousay L; Department of Biological Sciences, California State University, Long Beach, California, USA.
Sanathara N; Department of Pharmacological Sciences, University of California, Irvine, California, USA.
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Źródło :
Vitamins and hormones [Vitam Horm] 2015; Vol. 97, pp. 187-221. Date of Electronic Publication: 2015 Jan 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Models, Biological*
Reproduction*
Arcuate Nucleus of Hypothalamus/*metabolism
Nerve Tissue Proteins/*metabolism
Neurons/*metabolism
Opioid Peptides/*metabolism
Receptors, Opioid/*agonists
Animals ; Female ; Humans ; Ovary/physiology ; Posture ; Receptors, Opioid/metabolism ; Reproductive Behavior ; Sexual Behavior, Animal ; Signal Transduction
Czasopismo naukowe
Tytuł :
DNA Hypermethylation Induced by L-Methionine Leads to Oligodendroglial and Myelin Deficits and Schizophrenia-Like Behaviors in Adolescent Mice.
Autorzy :
Chen, Xianjun
Huang, Nan-Xin
Cheng, Yong-Jie
Cai, Qi-Yan
Tian, Yan-Ping
Chen, Xing-Shu
Xiao, Lan
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Temat :
MYELIN
NEURAL circuitry
DNA
DNA methylation
WHITE matter (Nerve tissue)
METHYLATION
Źródło :
Frontiers in Neuroscience; 4/20/2021, Vol. 15, pN.PAG-N.PAG, 10p
Czasopismo naukowe
Tytuł :
Aberrant Early in Life Stimulation of the Stress-Response System Affects Emotional Contagion and Oxytocin Regulation in Adult Male Mice.
Autorzy :
Laviola, Giovanni (AUTHOR)
Busdraghi, Ludovica Maria (AUTHOR)
Meschino, Noemi (AUTHOR)
Petrella, Carla (AUTHOR)
Fiore, Marco (AUTHOR)
Moon, Changjong (AUTHOR)
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Źródło :
International Journal of Molecular Sciences. May2021, Vol. 22 Issue 9, p5039-5039. 1p.
Czasopismo naukowe
Tytuł :
Methionine Diet Evoked Hyperhomocysteinemia Causes Hippocampal Alterations, Metabolomics Plasma Changes and Behavioral Pattern in Wild Type Rats.
Autorzy :
Kovalska, Maria (AUTHOR)
Baranovicova, Eva (AUTHOR)
Kalenska, Dagmar (AUTHOR)
Tomascova, Anna (AUTHOR)
Adamkov, Marian (AUTHOR)
Kovalska, Libusa (AUTHOR)
Lehotsky, Jan (AUTHOR)
Pluta, Ryszard (AUTHOR)
Andreadou, Ioanna (AUTHOR)
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Źródło :
International Journal of Molecular Sciences. May2021, Vol. 22 Issue 9, p4961-4961. 1p.
Czasopismo naukowe
Tytuł :
Protective Effects of Two Halophilic Crude Extracts from Pseudomonas zhaodongensis and Bacillus stratosphericus against Memory Deficits and Anxiety- and Depression-Like Behaviors in Methionine-Induced Schizophrenia in Mice Focusing on Oxidative Stress Status
Autorzy :
Massaoudi, Yousra
Anissi, Jaouad
Lefter, Radu
Lobiuc, Andrei
Sendide, Khalid
Ciobica, Alin
Hassouni, Mohammed El
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Temat :
ANIMAL experimentation
ANTIOXIDANTS
ANXIETY
BACILLUS (Bacteria)
BIOMARKERS
BIOLOGICAL models
COGNITION disorders
MENTAL depression
FLAVONOIDS
MEMORY
MEMORY disorders
METHIONINE
MICE
PHENOLS
PSEUDOMONAS
SCHIZOPHRENIA
TEMPORAL lobe
TISSUE extracts
OXIDATIVE stress
Źródło :
Evidence-based Complementary & Alternative Medicine (eCAM); 11/24/2020, p1-18, 18p, 1 Diagram, 5 Charts, 4 Graphs
Czasopismo naukowe
Tytuł :
Machine Learning Reduced Gene/Non-Coding RNA Features That Classify Schizophrenia Patients Accurately and Highlight Insightful Gene Clusters.
Autorzy :
Liu, Yichuan (AUTHOR)
Qu, Hui-Qi (AUTHOR)
Chang, Xiao (AUTHOR)
Tian, Lifeng (AUTHOR)
Qu, Jingchun (AUTHOR)
Glessner, Joseph (AUTHOR)
Sleiman, Patrick M. A. (AUTHOR)
Hakonarson, Hakon (AUTHOR)
Vallender, Eric (AUTHOR)
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Źródło :
International Journal of Molecular Sciences. Apr2021, Vol. 22 Issue 7, p3364. 1p.
Czasopismo naukowe
Tytuł :
Transcription factors in neurodevelopmental and associated psychiatric disorders: A potential convergence for genetic and environmental risk factors.
Autorzy :
Santos-Terra J; Translational Research Group in Autism Spectrum Disorders (GETTEA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.; Department of Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.; School of Pharmacology and Biomedical Sciences, University of Central Lancashire, Autism Wellbeing And Research Development (AWARD) Institute, BR-UK-CA, Preston, UK.
Deckmann I; Translational Research Group in Autism Spectrum Disorders (GETTEA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.; Department of Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.; School of Pharmacology and Biomedical Sciences, University of Central Lancashire, Autism Wellbeing And Research Development (AWARD) Institute, BR-UK-CA, Preston, UK.
Fontes-Dutra M; Translational Research Group in Autism Spectrum Disorders (GETTEA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.; Department of Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.; School of Pharmacology and Biomedical Sciences, University of Central Lancashire, Autism Wellbeing And Research Development (AWARD) Institute, BR-UK-CA, Preston, UK.
Schwingel GB; Translational Research Group in Autism Spectrum Disorders (GETTEA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.; Department of Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.; School of Pharmacology and Biomedical Sciences, University of Central Lancashire, Autism Wellbeing And Research Development (AWARD) Institute, BR-UK-CA, Preston, UK.
Bambini-Junior V; Translational Research Group in Autism Spectrum Disorders (GETTEA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.; School of Pharmacology and Biomedical Sciences, University of Central Lancashire, Autism Wellbeing And Research Development (AWARD) Institute, BR-UK-CA, Preston, UK.; School of Pharmacology and Biomedical Sciences, University of Central Lancashire, Preston, UK.
Gottfried C; Translational Research Group in Autism Spectrum Disorders (GETTEA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.; Department of Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.; School of Pharmacology and Biomedical Sciences, University of Central Lancashire, Autism Wellbeing And Research Development (AWARD) Institute, BR-UK-CA, Preston, UK.
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Źródło :
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience [Int J Dev Neurosci] 2021 Jul 08. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
Ciliary melanin‐concentrating hormone receptor 1 (MCHR1) is widely distributed in the murine CNS in a sex‐independent manner.
Autorzy :
Diniz, Giovanne B.
Battagello, Daniella S.
Klein, Marianne O.
Bono, Bianca S. M.
Ferreira, Jozélia G. P.
Motta‐Teixeira, Livia C.
Duarte, Jessica C. G.
Presse, Françoise
Nahon, Jean‐Louis
Adamantidis, Antoine
Chee, Melissa J.
Sita, Luciane V.
Bittencourt, Jackson C.
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Źródło :
Journal of Neuroscience Research; Oct2020, Vol. 98 Issue 10, p2045-2071, 27p
Czasopismo naukowe

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