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    Wyświetlanie 1-6 z 6
    Tytuł:
    Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study.
    Autorzy:
    Hastie KM; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
    Li H; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
    Bedinger D; Carterra, 825 N. 300 W. Ste C309, Salt Lake City, UT 84103, USA.
    Schendel SL; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
    Dennison SM; Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA.
    Li K; Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA.
    Rayaprolu V; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
    Yu X; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
    Mann C; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
    Zandonatti M; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
    Diaz Avalos R; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
    Zyla D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
    Buck T; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
    Hui S; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
    Shaffer K; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
    Hariharan C; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
    Yin J; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
    Olmedillas E; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
    Enriquez A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
    Parekh D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
    Abraha M; Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA.
    Feeney E; Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA.
    Horn GQ; Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA.
    Aldon Y; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, Netherlands.
    Ali H; Quadrucept Bio, Ltd., Cambridge CB23 6DW, UK.
    Aracic S; Myrio Therapeutics Pty, Ltd., 1 Dalmore Drive, Scoresby, VIC 3179, Australia.
    Cobb RR; National Resilience, Inc., 13200 NW Nano Ct., Alachua, FL 32615, USA.
    Federman RS; Generate Biomedicines, Inc., 26 Landsdowne Street, Cambridge, MA 02139, USA.
    Fernandez JM; Activemotif, Inc., 1914 Palomar Oaks Way, Suite 150, Carlsbad, CA 92008, USA.
    Glanville J; Centivax, Inc., 201 Gateway Blvd., Floor 1, South San Francisco, CA 94080, USA.
    Green R; Generate Biomedicines, Inc., 26 Landsdowne Street, Cambridge, MA 02139, USA.
    Grigoryan G; Generate Biomedicines, Inc., 26 Landsdowne Street, Cambridge, MA 02139, USA.
    Lujan Hernandez AG; Twist Bioscience, 681 Gateway Blvd., South San Francisco, CA 94080, USA.
    Ho DD; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, 701 West 168th St., HHSC 1102, New York, NY 10032, USA.
    Huang KA; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital and Research Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan.
    Ingraham J; Generate Biomedicines, Inc., 26 Landsdowne Street, Cambridge, MA 02139, USA.
    Jiang W; Shanghai Henlius Biotech, Inc., 9/F, Innov Tower, Zone A, no. 1801 Hongmei Road, Xuhui District, Shanghai, China.
    Kellam P; Kymab, Ltd., The Bennet Building, Babraham Research Campus, Cambridge CB22 3AT, UK.; Department of Infectious Disease, Imperial College, London SW7 2AZ, UK.
    Kim C; Celltrion, Inc., Department of Research and Development, 23 Academy-ro Yeonsu-gu Incheon, Republic of Korea.
    Kim M; Celltrion, Inc., Department of Research and Development, 23 Academy-ro Yeonsu-gu Incheon, Republic of Korea.
    Kim HM; Celltrion, Inc., Department of Research and Development, 23 Academy-ro Yeonsu-gu Incheon, Republic of Korea.
    Kong C; Sanyou Biopharmaceuticals Co., Ltd., no. 188 Xinjunhuan Road, Building 6B-C, 3rd Floor, Minhang District, Shanghai 201114, China.
    Krebs SJ; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
    Lan F; Activemotif, Inc., 1914 Palomar Oaks Way, Suite 150, Carlsbad, CA 92008, USA.; Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
    Lang G; Sanyou Biopharmaceuticals Co., Ltd., no. 188 Xinjunhuan Road, Building 6B-C, 3rd Floor, Minhang District, Shanghai 201114, China.
    Lee S; Celltrion, Inc., Department of Research and Development, 23 Academy-ro Yeonsu-gu Incheon, Republic of Korea.
    Leung CL; Generate Biomedicines, Inc., 26 Landsdowne Street, Cambridge, MA 02139, USA.
    Liu J; Shanghai Henlius Biotech, Inc., 9/F, Innov Tower, Zone A, no. 1801 Hongmei Road, Xuhui District, Shanghai, China.
    Lu Y; Activemotif, Inc., 1914 Palomar Oaks Way, Suite 150, Carlsbad, CA 92008, USA.; AbCipher Biotechnology, 188 Xinjun Ring Road, Building 2, 4th Floor, Minhang District, Shanghai 201114, China.
    MacCamy A; Fred Hutchinson Cancer Research Center, Vaccines and Infectious Diseases Division, Seattle, WA, USA.
    McGuire AT; Fred Hutchinson Cancer Research Center, Vaccines and Infectious Diseases Division, Seattle, WA, USA.
    Palser AL; Kymab, Ltd., The Bennet Building, Babraham Research Campus, Cambridge CB22 3AT, UK.
    Rabbitts TH; Quadrucept Bio, Ltd., Cambridge CB23 6DW, UK.; Institute of Cancer Research, Centre for Cancer Drug Discovery, London SM2 5NG, UK.
    Rikhtegaran Tehrani Z; Division of Clinical Care and Research, Institute of Human Virology, University of Maryland, Baltimore, MD 21201, USA.
    Sajadi MM; Division of Clinical Care and Research, Institute of Human Virology, University of Maryland, Baltimore, MD 21201, USA.
    Sanders RW; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, Netherlands.
    Sato AK; Twist Bioscience, 681 Gateway Blvd., South San Francisco, CA 94080, USA.
    Schweizer L; HiFiBiO, Inc., 237 Putnam Avenue, Cambridge, MA 02139, USA.
    Seo J; Celltrion, Inc., Department of Research and Development, 23 Academy-ro Yeonsu-gu Incheon, Republic of Korea.
    Shen B; HiFiBiO, Inc., 237 Putnam Avenue, Cambridge, MA 02139, USA.
    Snitselaar JL; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, Netherlands.
    Stamatatos L; Fred Hutchinson Cancer Research Center, Vaccines and Infectious Diseases Division, Seattle, WA, USA.
    Tan Y; Sanyou Biopharmaceuticals Co., Ltd., no. 188 Xinjunhuan Road, Building 6B-C, 3rd Floor, Minhang District, Shanghai 201114, China.
    Tomic MT; National Resilience, Inc., 2061 Challenger Dr., Alameda, CA 94501, USA.
    van Gils MJ; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, Netherlands.
    Youssef S; Centivax, Inc., 201 Gateway Blvd., Floor 1, South San Francisco, CA 94080, USA.
    Yu J; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, 701 West 168th St., HHSC 1102, New York, NY 10032, USA.
    Yuan TZ; Twist Bioscience, 681 Gateway Blvd., South San Francisco, CA 94080, USA.
    Zhang Q; HiFiBiO, Inc., 237 Putnam Avenue, Cambridge, MA 02139, USA.
    Peters B; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.; Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.
    Tomaras GD; Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA.
    Germann T; Carterra, 825 N. 300 W. Ste C309, Salt Lake City, UT 84103, USA.
    Saphire EO; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.; Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.
    Pokaż więcej
    Corporate Authors:
    CoVIC-DB team1
    Źródło:
    Science (New York, N.Y.) [Science] 2021 Oct 22; Vol. 374 (6566), pp. 472-478. Date of Electronic Publication: 2021 Sep 23.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Epitope Mapping*
    Antibodies, Neutralizing/*immunology
    Antibodies, Viral/*immunology
    Immunodominant Epitopes/*immunology
    SARS-CoV-2/*immunology
    Spike Glycoprotein, Coronavirus/*immunology
    Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/therapeutic use ; Antigens, Viral/chemistry ; Antigens, Viral/immunology ; COVID-19/therapy ; Humans ; Immunodominant Epitopes/chemistry ; Protein Binding ; Protein Domains ; Spike Glycoprotein, Coronavirus/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection.
    Autorzy:
    Dan JM; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
    Mateus J; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
    Kato Y; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
    Hastie KM; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
    Yu ED; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
    Faliti CE; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
    Grifoni A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
    Ramirez SI; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
    Haupt S; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
    Frazier A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
    Nakao C; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
    Rayaprolu V; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
    Rawlings SA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
    Peters B; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.; Department of Medicine, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
    Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
    Simon V; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; The Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
    Saphire EO; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
    Smith DM; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
    Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA. .
    Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA. .; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
    Crotty S; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA. .; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
    Pokaż więcej
    Źródło:
    Science (New York, N.Y.) [Science] 2021 Feb 05; Vol. 371 (6529). Date of Electronic Publication: 2021 Jan 06.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Immunologic Memory*
    Antibodies, Viral/*blood
    COVID-19/*immunology
    Adult ; Aged ; Aged, 80 and over ; Antibodies, Neutralizing/blood ; B-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cross-Sectional Studies ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Spike Glycoprotein, Coronavirus/immunology ; United States ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses.
    Autorzy:
    Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Nyakatura EK; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
    Howell KA; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
    Holtsberg FW; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
    Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
    Mittler E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Christin JR; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Shulenin S; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
    Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Bharrhan S; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
    Bornholdt ZA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 10550, USA.
    Flyak AI; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37235, USA.
    Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 10550, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 10550, USA.
    Crowe JE Jr; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37235, USA. .; Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA.; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA.
    Aman MJ; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA. .
    Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. .
    Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA. .
    Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. .
    Pokaż więcej
    Źródło:
    Science (New York, N.Y.) [Science] 2016 Oct 21; Vol. 354 (6310), pp. 350-354. Date of Electronic Publication: 2016 Sep 08.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antibodies, Bispecific/*immunology
    Antibodies, Neutralizing/*immunology
    Antibodies, Viral/*immunology
    Carrier Proteins/*immunology
    Ebolavirus/*immunology
    Hemorrhagic Fever, Ebola/*prevention & control
    Membrane Glycoproteins/*immunology
    Receptors, Virus/*immunology
    Viral Envelope Proteins/*immunology
    Animals ; Antibodies, Monoclonal/immunology ; Binding Sites/immunology ; Cell Line, Tumor ; Endosomes/virology ; Hemorrhagic Fever, Ebola/therapy ; Humans ; Immunotherapy/methods ; Intracellular Signaling Peptides and Proteins ; Mice ; Mice, Inbred BALB C ; Niemann-Pick C1 Protein ; Virus Internalization
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak.
    Autorzy:
    Bornholdt ZA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Murin CD; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Li W; Adimab, Lebanon, NH 03766, USA.
    Sok D; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Souders CA; MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.
    Piper AE; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
    Goff A; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
    Shamblin JD; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
    Wollen SE; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
    Sprague TR; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
    Fusco ML; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Pommert KB; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Cavacini LA; MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.
    Smith HL; MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.
    Klempner M; MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.
    Reimann KA; MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.
    Krauland E; Adimab, Lebanon, NH 03766, USA.
    Gerngross TU; Adimab, Lebanon, NH 03766, USA.
    Wittrup KD; Adimab, Lebanon, NH 03766, USA.
    Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Burton DR; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02142, USA.
    Glass PJ; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
    Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Walker LM; Adimab, Lebanon, NH 03766, USA.
    Pokaż więcej
    Źródło:
    Science (New York, N.Y.) [Science] 2016 Mar 04; Vol. 351 (6277), pp. 1078-83. Date of Electronic Publication: 2016 Feb 18.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Antibodies, Monoclonal/*isolation & purification
    Antibodies, Neutralizing/*isolation & purification
    Antibodies, Viral/*isolation & purification
    Ebolavirus/*immunology
    Hemorrhagic Fever, Ebola/*immunology
    Viral Envelope Proteins/*immunology
    Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/chemistry ; Antibodies, Viral/therapeutic use ; Antibody Formation ; Antigen-Antibody Complex/chemistry ; Democratic Republic of the Congo/epidemiology ; Disease Outbreaks ; Ebola Vaccines/immunology ; Ebola Vaccines/therapeutic use ; Hemorrhagic Fever, Ebola/epidemiology ; Hemorrhagic Fever, Ebola/therapy ; Humans ; Immunization, Passive ; Mice ; Survivors ; Tissue Donors ; Viral Envelope Proteins/chemistry ; Virion/immunology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Structural basis for differential neutralization of ebolaviruses.
    Autorzy:
    Bale S; Dept. of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Dias JM
    Fusco ML
    Hashiguchi T
    Wong AC
    Liu T
    Keuhne AI
    Li S
    Woods VL Jr
    Chandran K
    Dye JM
    Saphire EO
    Pokaż więcej
    Źródło:
    Viruses [Viruses] 2012 Apr; Vol. 4 (4), pp. 447-70. Date of Electronic Publication: 2012 Apr 05.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
    MeSH Terms:
    Antibodies, Neutralizing/*immunology
    Antibodies, Viral/*immunology
    Ebolavirus/*immunology
    Viral Envelope Proteins/*immunology
    Antibodies, Neutralizing/chemistry ; Antibodies, Viral/chemistry ; Antibody Affinity ; Crystallography, X-Ray ; Epitopes ; Models, Molecular ; Neutralization Tests ; Protein Binding ; Protein Structure, Quaternary ; Viral Envelope Proteins/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor.
    Autorzy:
    Lee JE; Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, Mail Drop IMM-2, La Jolla, California 92037, USA.
    Fusco ML
    Hessell AJ
    Oswald WB
    Burton DR
    Saphire EO
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    Źródło:
    Nature [Nature] 2008 Jul 10; Vol. 454 (7201), pp. 177-82.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Survivors*
    Antibodies, Viral/*immunology
    Ebolavirus/*chemistry
    Glycoproteins/*chemistry
    Glycoproteins/*immunology
    Animals ; Antibodies, Viral/genetics ; Binding Sites, Antibody ; Cathepsins/metabolism ; Cell Line ; Cricetinae ; Cricetulus ; Crystallography, X-Ray ; Democratic Republic of the Congo ; Ebolavirus/immunology ; Glycoproteins/metabolism ; Glycosylation ; Humans ; Membrane Fusion ; Models, Molecular ; Protein Conformation ; Receptors, Virus/chemistry ; Receptors, Virus/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-6 z 6

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