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    Tytuł:
    Persistent intraocular Ebola virus RNA is associated with severe uveitis in a convalescent rhesus monkey.
    Autorzy:
    Worwa G; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick, Frederick, MD, 21702, USA. .
    Cooper TK; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick, Frederick, MD, 21702, USA.
    Yeh S; Emory Eye Center, Emory University, Atlanta, GA, 30322, USA.; Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, 68105, USA.
    Shantha JG; Emory Eye Center, Emory University, Atlanta, GA, 30322, USA.
    Hischak AMW; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick, Frederick, MD, 21702, USA.
    Klim SE; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick, Frederick, MD, 21702, USA.
    Byrum R; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick, Frederick, MD, 21702, USA.
    Kurtz JR; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick, Frederick, MD, 21702, USA.
    Anthony SM; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick, Frederick, MD, 21702, USA.
    Aiosa NM; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick, Frederick, MD, 21702, USA.
    Ragland D; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick, Frederick, MD, 21702, USA.
    Lee JH; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick, Frederick, MD, 21702, USA.
    Claire MS; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick, Frederick, MD, 21702, USA.
    Davis C; Emory Vaccine Center, Emory University, Atlanta, GA, 30322, USA.
    Ahmed R; Emory Vaccine Center, Emory University, Atlanta, GA, 30322, USA.
    Holbrook MR; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick, Frederick, MD, 21702, USA.
    Kuhn JH; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick, Frederick, MD, 21702, USA.
    Saphire EO; Center for Infectious Disease and Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, 92065, USA.
    Crozier I; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Fort Detrick, Frederick, MD, 21702, USA. .; Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA. .
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    Źródło:
    Communications biology [Commun Biol] 2022 Nov 09; Vol. 5 (1), pp. 1204. Date of Electronic Publication: 2022 Nov 09.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Hemorrhagic Fever, Ebola*/complications
    Ebolavirus*/physiology
    Uveitis*/complications
    Uveitis*/diagnosis
    Animals ; Humans ; Macaca mulatta ; RNA
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Pan-ebolavirus serology study of healthcare workers in the Mbandaka Health Region, Democratic Republic of the Congo.
    Autorzy:
    Shaffer KCL; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, United States of America.
    Hui S; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, United States of America.
    Bratcher A; Department of Epidemiology, UCLA Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California, United States of America.
    King LB; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, United States of America.; Department of Medicine, University of California, San Diego, La Jolla, California, United States of America.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.
    Mutombe R; Institut National de Recherche Biomedicale, Kinshasa, Democratic Republic of the Congo.
    Kavira N; Institut National de Recherche Biomedicale, Kinshasa, Democratic Republic of the Congo.
    Kompany JP; Institut National de Recherche Biomedicale, Kinshasa, Democratic Republic of the Congo.
    Tambu M; Institut National de Recherche Biomedicale, Kinshasa, Democratic Republic of the Congo.
    Musene K; Institut National de Recherche Biomedicale, Kinshasa, Democratic Republic of the Congo.
    Mukadi P; Institut National de Recherche Biomedicale, Kinshasa, Democratic Republic of the Congo.
    Mbala P; Institut National de Recherche Biomedicale, Kinshasa, Democratic Republic of the Congo.
    Gadoth A; Department of Epidemiology, UCLA Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California, United States of America.
    West BR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.
    Ilunga BK; Directorate of Disease Control, Ministry of Public Health, Kinshasa, Democratic Republic of the Congo.
    Kaba D; Kinshasa School of Public Health, Kinshasa, Democratic Republic of the Congo.
    Muyembe-Tanfum JJ; Institut National de Recherche Biomedicale, Kinshasa, Democratic Republic of the Congo.
    Hoff NA; Department of Epidemiology, UCLA Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California, United States of America.
    Rimoin AW; Department of Epidemiology, UCLA Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California, United States of America.
    Saphire EO; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, United States of America.; Department of Medicine, University of California, San Diego, La Jolla, California, United States of America.
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    Źródło:
    PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2022 Mar 07; Vol. 16 (3), pp. e0010167. Date of Electronic Publication: 2022 Mar 07 (Print Publication: 2022).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Ebolavirus*
    Hemorrhagic Fever, Ebola*
    Antibodies, Viral ; Democratic Republic of the Congo/epidemiology ; Glycoproteins ; Health Personnel ; Humans ; Immunoglobulin G
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry.
    Autorzy:
    Schafer A; Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.
    Xiong R; Department of Pharmaceutical Sciences, College of Pharmacy, and UICentre, University of Illinois at Chicago, Chicago, Illinois, United States of America.
    Cooper L; Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.; Department of Pharmaceutical Sciences, College of Pharmacy, and UICentre, University of Illinois at Chicago, Chicago, Illinois, United States of America.
    Nowar R; Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.; Department of Pharmaceutical Sciences, College of Pharmacy, and UICentre, University of Illinois at Chicago, Chicago, Illinois, United States of America.
    Lee H; Department of Pharmaceutical Sciences, College of Pharmacy, and UICentre, University of Illinois at Chicago, Chicago, Illinois, United States of America.; Biophysics core, Research Resources Center, University of Illinois at Chicago, Chicago, Illinois, United States of America.
    Li Y; Department of Pharmaceutical Sciences, College of Pharmacy, and UICentre, University of Illinois at Chicago, Chicago, Illinois, United States of America.
    Ramirez BE; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, United States of America.; NMR Core, Research Resources Center, University of Illinois at Chicago, Chicago, Illinois, United States of America.
    Peet NP; Chicago BioSolutions Inc., Chicago, Illinois, United States of America.
    Caffrey M; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, United States of America.
    Thatcher GRJ; Department of Pharmaceutical Sciences, College of Pharmacy, and UICentre, University of Illinois at Chicago, Chicago, Illinois, United States of America.
    Saphire EO; La Jolla Institute for Immunology, La Jolla, California, United States of America.
    Cheng H; Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.
    Rong L; Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.
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    Źródło:
    PLoS pathogens [PLoS Pathog] 2021 Feb 04; Vol. 17 (2), pp. e1009312. Date of Electronic Publication: 2021 Feb 04 (Print Publication: 2021).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Antiviral Agents/*pharmacology
    Ebolavirus/*drug effects
    Glycoproteins/*metabolism
    Hemorrhagic Fever, Ebola/*drug therapy
    Small Molecule Libraries/*pharmacology
    Viral Envelope Proteins/*metabolism
    Virus Internalization/*drug effects
    A549 Cells ; Animals ; Chlorocebus aethiops ; Ebolavirus/physiology ; Glycoproteins/genetics ; Hemorrhagic Fever, Ebola/metabolism ; Hemorrhagic Fever, Ebola/pathology ; Hemorrhagic Fever, Ebola/virology ; Host-Pathogen Interactions ; Humans ; Lysosomes/drug effects ; Lysosomes/virology ; Vero Cells ; Viral Envelope Proteins/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses.
    Autorzy:
    Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Nyakatura EK; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
    Howell KA; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
    Holtsberg FW; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
    Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
    Mittler E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Christin JR; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Shulenin S; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
    Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Bharrhan S; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
    Bornholdt ZA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 10550, USA.
    Flyak AI; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37235, USA.
    Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 10550, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 10550, USA.
    Crowe JE Jr; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37235, USA. .; Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA.; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA.
    Aman MJ; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA. .
    Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. .
    Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA. .
    Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. .
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    Źródło:
    Science (New York, N.Y.) [Science] 2016 Oct 21; Vol. 354 (6310), pp. 350-354. Date of Electronic Publication: 2016 Sep 08.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antibodies, Bispecific/*immunology
    Antibodies, Neutralizing/*immunology
    Antibodies, Viral/*immunology
    Carrier Proteins/*immunology
    Ebolavirus/*immunology
    Hemorrhagic Fever, Ebola/*prevention & control
    Membrane Glycoproteins/*immunology
    Receptors, Virus/*immunology
    Viral Envelope Proteins/*immunology
    Animals ; Antibodies, Monoclonal/immunology ; Binding Sites/immunology ; Cell Line, Tumor ; Endosomes/virology ; Hemorrhagic Fever, Ebola/therapy ; Humans ; Immunotherapy/methods ; Intracellular Signaling Peptides and Proteins ; Mice ; Mice, Inbred BALB C ; Niemann-Pick C1 Protein ; Virus Internalization
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak.
    Autorzy:
    Bornholdt ZA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Murin CD; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Li W; Adimab, Lebanon, NH 03766, USA.
    Sok D; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Souders CA; MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.
    Piper AE; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
    Goff A; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
    Shamblin JD; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
    Wollen SE; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
    Sprague TR; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
    Fusco ML; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Pommert KB; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Cavacini LA; MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.
    Smith HL; MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.
    Klempner M; MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.
    Reimann KA; MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.
    Krauland E; Adimab, Lebanon, NH 03766, USA.
    Gerngross TU; Adimab, Lebanon, NH 03766, USA.
    Wittrup KD; Adimab, Lebanon, NH 03766, USA.
    Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Burton DR; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02142, USA.
    Glass PJ; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
    Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Walker LM; Adimab, Lebanon, NH 03766, USA.
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    Źródło:
    Science (New York, N.Y.) [Science] 2016 Mar 04; Vol. 351 (6277), pp. 1078-83. Date of Electronic Publication: 2016 Feb 18.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Antibodies, Monoclonal/*isolation & purification
    Antibodies, Neutralizing/*isolation & purification
    Antibodies, Viral/*isolation & purification
    Ebolavirus/*immunology
    Hemorrhagic Fever, Ebola/*immunology
    Viral Envelope Proteins/*immunology
    Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/chemistry ; Antibodies, Viral/therapeutic use ; Antibody Formation ; Antigen-Antibody Complex/chemistry ; Democratic Republic of the Congo/epidemiology ; Disease Outbreaks ; Ebola Vaccines/immunology ; Ebola Vaccines/therapeutic use ; Hemorrhagic Fever, Ebola/epidemiology ; Hemorrhagic Fever, Ebola/therapy ; Humans ; Immunization, Passive ; Mice ; Survivors ; Tissue Donors ; Viral Envelope Proteins/chemistry ; Virion/immunology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs.
    Autorzy:
    Fusco ML; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America.
    Hashiguchi T; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America; Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
    Cassan R; Emergent BioSolutions (formerly Cangene Corporation), Winnipeg, Manitoba, Canada.
    Biggins JE; Division of Virology, United States Army Research Institute for Infectious Disease, Ft. Detrick, Maryland, United States of America; Integrated Biotherapeutics, Inc., Gaithersburg, Maryland, United States of America.
    Murin CD; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
    Warfield KL; Integrated Biotherapeutics, Inc., Gaithersburg, Maryland, United States of America.
    Li S; Department of Medicine, University of California San Diego, La Jolla, California, United States of America.
    Holtsberg FW; Integrated Biotherapeutics, Inc., Gaithersburg, Maryland, United States of America.
    Shulenin S; Integrated Biotherapeutics, Inc., Gaithersburg, Maryland, United States of America.
    Vu H; Integrated Biotherapeutics, Inc., Gaithersburg, Maryland, United States of America.
    Olinger GG; Division of Virology, United States Army Research Institute for Infectious Disease, Ft. Detrick, Maryland, United States of America; Integrated Research Facility, NIAID, National Institutes of Health, Frederick, Maryland, United States of America.
    Kim DH; Mapp Biopharmaceutical, Inc., San Diego, California, United States of America.
    Whaley KJ; Mapp Biopharmaceutical, Inc., San Diego, California, United States of America.
    Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, California, United States of America.
    Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
    Nykiforuk C; Emergent BioSolutions (formerly Cangene Corporation), Winnipeg, Manitoba, Canada.
    Aman MJ; Integrated Biotherapeutics, Inc., Gaithersburg, Maryland, United States of America.
    Berry JD
    Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America.
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    Źródło:
    PLoS pathogens [PLoS Pathog] 2015 Jun 26; Vol. 11 (6), pp. e1005016. Date of Electronic Publication: 2015 Jun 26 (Print Publication: 2015).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Immunization*
    Antibodies, Monoclonal/*immunology
    Antibodies, Monoclonal/*pharmacology
    Hemorrhagic Fever, Ebola/*immunology
    Marburg Virus Disease/*prevention & control
    Marburgvirus/*immunology
    Animals ; Antibodies, Viral/immunology ; Cross Reactions/immunology ; Ebolavirus/immunology ; Female ; Male ; Marburg Virus Disease/immunology ; Mice, Inbred BALB C
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-6 z 6

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