Activity and inhibition of the SARS-CoV-2 Omicron nsp13 R392C variant using RNA duplex unwinding assays.
Autorzy:
Inniss NL; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA; Center for Structural Biology of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA. Rzhetskaya M; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA; Center for Pathogen Genomics and Microbial Evolution, Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA. Ling-Hu T; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA; Center for Pathogen Genomics and Microbial Evolution, Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA. Lorenzo-Redondo R; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA; Center for Pathogen Genomics and Microbial Evolution, Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA. Bachta KE; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA; Center for Pathogen Genomics and Microbial Evolution, Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA. SatchellKJF; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA; Center for Structural Biology of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA; Center for Pathogen Genomics and Microbial Evolution, Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA. Electronic address: k-satchell@northwestern.edu. Hultquist JF; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA; Center for Pathogen Genomics and Microbial Evolution, Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 USA. Electronic address: .
Biochemical and Structural Analysis of the Bacterial Enzyme Succinyl-Diaminopimelate Desuccinylase (DapE) from Acinetobacter baumannii .
Autorzy:
Kelley EH; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States. Minasov G; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States.; Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States. Konczak K; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States. Shuvalova L; Department of Pharmacology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States. Brunzelle JS; Northwestern Synchrotron Research Center, Life Sciences Collaborative Access Team, Northwestern University, Argonne, Illinois 60439, United States. Shukla S; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States.; Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States. Beulke M; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States. Thabthimthong T; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States. Olsen KW; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States. Inniss NL; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States.; Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States. SatchellKJF; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States.; Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States. Becker DP; Department of Chemistry and Biochemistry, Loyola University Chicago, 1032 West Sheridan Road, Chicago, Illinois 60660, United States.
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Źródło:
ACS omega [ACS Omega] 2024 Jan 08; Vol. 9 (3), pp. 3905-3915. Date of Electronic Publication: 2024 Jan 08 (Print Publication: 2024).
Discovery of a Druggable, Cryptic Pocket in SARS-CoV-2 nsp16 Using Allosteric Inhibitors.
Autorzy:
Inniss NL; Department of Microbiology-Immunology and Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States. Kozic J; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 6, 160 00, Czech Republic. Li F; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada. Rosas-Lemus M; Department of Microbiology-Immunology and Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States. Minasov G; Department of Microbiology-Immunology and Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States. Rybáček J; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 6, 160 00, Czech Republic. Zhu Y; WuXi AppTec Co., Ltd, China (Shanghai) Pilot Free Trade Zone, Shanghai, 201308, China. Pohl R; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 6, 160 00, Czech Republic. Shuvalova L; Department of Pharmacology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States. Rulíšek L; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 6, 160 00, Czech Republic. Brunzelle JS; Northwestern Synchrotron Research Center, Life Sciences Collaborative Access Team, Northwestern University, Argonne, Illinois 60439, United States. Bednárová L; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 6, 160 00, Czech Republic. Štefek M; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 6, 160 00, Czech Republic. Kormaník JM; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 6, 160 00, Czech Republic. Andris E; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 6, 160 00, Czech Republic. Šebestík J; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 6, 160 00, Czech Republic. Li ASM; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada. Brown PJ; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada. Schmitz U; Structural Chemistry, Gilead Pharmaceuticals, San Mateo, California 94404, United States. Saikatendu K; Takeda Development Center Americas, Inc., San Diego, California 92121, United States. Chang E; Takeda Development Center Americas, Inc., San Diego, California 92121, United States. Nencka R; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 6, 160 00, Czech Republic. Vedadi M; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada. SatchellKJF; Department of Microbiology-Immunology and Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, United States.
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Źródło:
ACS infectious diseases [ACS Infect Dis] 2023 Oct 13; Vol. 9 (10), pp. 1918-1931. Date of Electronic Publication: 2023 Sep 20.
RAS degraders: The new frontier for RAS-driven cancers.
Autorzy:
Escher TE; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Research Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA. SatchellKJF; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Research Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: k-satchell@northwestern.edu.
Serodominant SARS-CoV-2 Nucleocapsid Peptides Map to Unstructured Protein Regions.
Autorzy:
Vandervaart JP; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA. Inniss NL; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.; Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA. Ling-Hu T; Department of Medicine, Division of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA. Minasov G; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.; Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA. Wiersum G; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.; Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA. Rosas-Lemus M; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.; Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA. Shuvalova L; Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Pharmacology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA. Achenbach CJ; Department of Medicine, Division of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA. Hultquist JF; Department of Medicine, Division of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA. SatchellKJF; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.; Center for Structural Biology of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA. Bachta KER; Department of Medicine, Division of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
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Źródło:
Microbiology spectrum [Microbiol Spectr] 2023 Jun 15; Vol. 11 (3), pp. e0032423. Date of Electronic Publication: 2023 May 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Genetic Divergence of Vibrio vulnificus Clinical Isolates with Mild to Severe Outcomes.
Autorzy:
Kling K; Division of Infectious Diseases, Department of Medicine, Northwestern Universitygrid.16753.36 Feinberg School of Medicine, Chicago, Illinois, USA. Trinh SA; Division of Infectious Diseases, Ochsner Medical Centergrid.240416.5, New Orleans, Louisiana, USA. Leyn SA; Sanford Burnham Prebys Medical Discovery Institute, LaJolla, California, USA. Rodionov DA; Sanford Burnham Prebys Medical Discovery Institute, LaJolla, California, USA. Rodionov ID; University of California, San Diego, La Jolla, California, USA. Herrera A; Division of Infectious Diseases, Department of Medicine, Northwestern Universitygrid.16753.36 Feinberg School of Medicine, Chicago, Illinois, USA. Cervantes K; Division of Infectious Diseases, Department of Medicine, Northwestern Universitygrid.16753.36 Feinberg School of Medicine, Chicago, Illinois, USA. Pankey G; Infectious Disease Translational Research, Ochsner Clinic Foundation, New Orleans, Louisiana, USA. Ashcraft D; Infectious Disease Translational Research, Ochsner Clinic Foundation, New Orleans, Louisiana, USA. Ozer EA; Division of Infectious Diseases, Department of Medicine, Northwestern Universitygrid.16753.36 Feinberg School of Medicine, Chicago, Illinois, USA. Godzik A; Biosciences Division, University of California Riverside School of Medicine, Riverside, California, USA. SatchellKJF; Department of Microbiology-Immunology, Northwestern Universitygrid.16753.36 Feinberg School of Medicine, Chicago, Illinois, USA.
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Źródło:
MBio [mBio] 2022 Oct 26; Vol. 13 (5), pp. e0150022. Date of Electronic Publication: 2022 Sep 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Structure of the Monkeypox virus profilin-like protein A42R reveals potential functional differences from cellular profilins.
Autorzy:
Minasov G; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Inniss NL; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Shuvalova L; Center for Structural Genomics of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Anderson WF; Center for Structural Genomics of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. SatchellKJF; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Identification of Clostridium innocuum hypothetical protein that is cross-reactive with C. difficile anti-toxin antibodies.
Autorzy:
Cherny KE; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA; Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. Electronic address: . Balaji A; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA. Mukherjee J; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA. Goo YA; Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. Hauser AR; Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. Ozer E; Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. SatchellKJF; Northwestern University, Feinberg School of Medicine, Chicago, IL, USA; Center for Structural Genomics of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. Bachta KER; Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. Kochan TJ; Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. Mitra SD; Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. Kociolek LK; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA; Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
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Źródło:
Anaerobe [Anaerobe] 2022 Jun; Vol. 75, pp. 102555. Date of Electronic Publication: 2022 Mar 31.
Bacterial Toxin and Effector Regulation of Intestinal Immune Signaling.
Autorzy:
Woida PJ; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States. SatchellKJF; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Assessment of Virological Contributions to COVID-19 Outcomes in a Longitudinal Cohort of Hospitalized Adults.
Autorzy:
Simons LM; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Lorenzo-Redondo R; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Gibson M; Division of Organ Transplantation, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Kinch SL; Division of Organ Transplantation, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Vandervaart JP; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Reiser NL; Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Eren M; Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Lux E; Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. McNally EM; Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Tambur AR; Division of Organ Transplantation, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Vaughan DE; Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Bachta KER; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Demonbreun AR; Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. SatchellKJF; Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Center for Structural Genomics of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Achenbach CJ; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Center for Global Communicable and Emerging Infectious Diseases, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Ozer EA; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Ison MG; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Division of Organ Transplantation, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Hultquist JF; Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
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Źródło:
Open forum infectious diseases [Open Forum Infect Dis] 2022 Feb 14; Vol. 9 (3), pp. ofac027. Date of Electronic Publication: 2022 Feb 14 (Print Publication: 2022).
RAS specific protease induces irreversible growth arrest via p27 in several KRAS mutant colorectal cancer cell lines.
Autorzy:
Stubbs CK; Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. Biancucci M; Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.; GSK Vaccines, Rockville, MD, 20850, USA. Vidimar V; Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.; Merck Research Laboratories, Boston, MA, 02115, USA. SatchellKJF; Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. k-satchell@northwestern.edu.
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Źródło:
Scientific reports [Sci Rep] 2021 Sep 09; Vol. 11 (1), pp. 17925. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
The ChiS-Family DNA-Binding Domain Contains a Cryptic Helix-Turn-Helix Variant.
Autorzy:
Klancher CA; Department of Biology, Indiana University, Bloomington, Indiana, USA. Minasov G; Center for Structural Genomics of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. Podicheti R; Center for Genomics and Bioinformatics, Indiana University, Bloomington, Indiana, USA. Rusch DB; Center for Genomics and Bioinformatics, Indiana University, Bloomington, Indiana, USA. Dalia TN; Department of Biology, Indiana University, Bloomington, Indiana, USA. SatchellKJF; Center for Structural Genomics of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. Neiditch MB; Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers Biomedical Health Sciences, Newark, New Jersey, USA. Dalia AB; Department of Biology, Indiana University, Bloomington, Indiana, USA .
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Źródło:
MBio [mBio] 2021 Mar 16; Vol. 12 (2). Date of Electronic Publication: 2021 Mar 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity.
Autorzy:
Blum TR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA. Liu H; Department of Urology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA. Packer MS; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA. Xiong X; Department of Urology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA. Lee PG; Department of Urology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA. Zhang S; Department of Urology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA. Richter M; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA. Minasov G; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. SatchellKJF; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Dong M; Department of Urology, Boston Children's Hospital, Boston, MA 02115, USA. .; Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA. Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. .; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
Anthrax Protective Antigen Retargeted with Single-Chain Variable Fragments Delivers Enzymes to Pancreatic Cancer Cells.
Autorzy:
Loftis AR; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Santos MS; Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Truex NL; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Biancucci M; Department of Microbiology-Immunology Feinberg School of Medicine, Northwestern University, 420 E Superior Street, Chicago, IL 60611, USA. SatchellKJF; Department of Microbiology-Immunology Feinberg School of Medicine, Northwestern University, 420 E Superior Street, Chicago, IL 60611, USA. Pentelute BL; Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02142, USA.; Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.
Comparison of metal-bound and unbound structures of aminopeptidase B proteins from Escherichia coli and Yersinia pestis.
Autorzy:
Minasov G; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Center for Structural Genomics of Infectious Diseases, Northwestern University, Chicago, Illinois, USA. Lam MR; Department of Molecular Biosciences, Weinberg School of Arts and Sciences, Northwestern University, Evanston, Illinois, USA. Rosas-Lemus M; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Center for Structural Genomics of Infectious Diseases, Northwestern University, Chicago, Illinois, USA. Sławek J; Center for Structural Genomics of Infectious Diseases, Northwestern University, Chicago, Illinois, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA. Woinska M; Center for Structural Genomics of Infectious Diseases, Northwestern University, Chicago, Illinois, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA. Shabalin IG; Center for Structural Genomics of Infectious Diseases, Northwestern University, Chicago, Illinois, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA. Shuvalova L; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Center for Structural Genomics of Infectious Diseases, Northwestern University, Chicago, Illinois, USA. Palsson BØ; Department of Bioengineering and Pediatrics, University of California, San Diego, California, USA. Godzik A; Center for Structural Genomics of Infectious Diseases, Northwestern University, Chicago, Illinois, USA.; Department of Biomedical Sciences, University of California, Riverside School of Medicine, Riverside, California, USA. Minor W; Center for Structural Genomics of Infectious Diseases, Northwestern University, Chicago, Illinois, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA. SatchellKJF; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Center for Structural Genomics of Infectious Diseases, Northwestern University, Chicago, Illinois, USA.
Lemichez E; Unité des Toxines Bactériennes, CNRS ERL6002, Institut Pasteur, Paris, France. Popoff MR; Unité des Toxines Bactériennes, CNRS ERL6002, Institut Pasteur, Paris, France. SatchellKJF; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Structure of galactarate dehydratase, a new fold in an enolase involved in bacterial fitness after antibiotic treatment.
Autorzy:
Rosas-Lemus M; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Center for Structural Genomics of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois. Minasov G; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Center for Structural Genomics of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois. Shuvalova L; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Center for Structural Genomics of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois. Wawrzak Z; Northwestern Synchrotron Research Center-LS-CAT, Northwestern University, Argonne, Illinois. Kiryukhina O; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Center for Structural Genomics of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois. Mih N; Department of Bioengineering, University of California San Diego, La Jolla, California. Jaroszewski L; Center for Structural Genomics of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Department of Biomedical Sciences, University of California at Riverside, Riverside, California. Palsson B; Department of Bioengineering, University of California San Diego, La Jolla, California.; Systems Biology Center for Antibiotic Resistance, University of California San Diego, La Jolla, California. Godzik A; Center for Structural Genomics of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Department of Biomedical Sciences, University of California at Riverside, Riverside, California. SatchellKJF; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Center for Structural Genomics of Infectious Diseases, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
N-terminal autoprocessing and acetylation of multifunctional-autoprocessing repeats-in-toxins (MARTX) Makes Caterpillars Floppy-like effector is stimulated by adenosine diphosphate (ADP)-Ribosylation Factor 1 in advance of Golgi fragmentation.
Autorzy:
Herrera A; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Muroski J; Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California. Sengupta R; Department of Biological Sciences, Purdue University, West Lafayette, Indiana. Nguyen HH; Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California. Agarwal S; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Ogorzalek Loo RR; Department of Biological Chemistry, David Geffen School of Medicine, UCLA Molecular Biology Institute, University of California-Los Angeles, Los Angeles, California.; UCLA/DOE Institute of Genomics and Proteomics, University of California-Los Angeles, Los Angeles, California. Mattoo S; Department of Biological Sciences, Purdue University, West Lafayette, Indiana.; Purdue Institute for Inflammation, Immunology and Infectious Diseases, Purdue University, West Lafayette, Indiana. Loo JA; Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California.; Department of Biological Chemistry, David Geffen School of Medicine, UCLA Molecular Biology Institute, University of California-Los Angeles, Los Angeles, California. SatchellKJF; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
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Źródło:
Cellular microbiology [Cell Microbiol] 2020 Feb; Vol. 22 (2), pp. e13133. Date of Electronic Publication: 2019 Nov 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
The Cyclic AMP Receptor Protein Regulates Quorum Sensing and Global Gene Expression in Yersinia pestis during Planktonic Growth and Growth in Biofilms.
Autorzy:
Ritzert JT; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Minasov G; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Center for Structural Genomics of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. Embry R; Center for Genetic Medicine, Northwestern University, Chicago, Illinois, USA. Schipma MJ; Center for Genetic Medicine, Northwestern University, Chicago, Illinois, USA. SatchellKJF; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA k-satchell@northwestern.edu.; Center for Structural Genomics of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
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Źródło:
MBio [mBio] 2019 Nov 19; Vol. 10 (6). Date of Electronic Publication: 2019 Nov 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
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