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Tytuł :
Triazole tethered isatin-coumarin based molecular hybrids as novel antitubulin agents: Design, synthesis, biological investigation and docking studies.
Autorzy :
Singh H; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143005, India.
Singh JV; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143005, India.
Gupta MK; Lloyd Institute of Management and Technology, Greater Noida, UP, India.
Saxena AK; Indian Institute of Integrative Medicine, Jammu, India.
Sharma S; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143005, India. Electronic address: .
Nepali K; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143005, India.
Bedi PMS; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143005, India.
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Sep 01; Vol. 27 (17), pp. 3974-3979. Date of Electronic Publication: 2017 Jul 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Coumarins/*pharmacology
Isatin/*pharmacology
Triazoles/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Coumarins/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Isatin/chemistry ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship ; Triazoles/chemistry
Czasopismo naukowe
Tytuł :
Synthesis of a novel series of artemisinin dimers with potent anticancer activity involving Sonogashira cross-coupling reaction.
Autorzy :
Buragohain P; Natural Products Chemistry Division, CSIR-North-East Institute of Science & Technology, Jorhat 785006, Assam, India.
Saikia B; Natural Products Chemistry Division, CSIR-North-East Institute of Science & Technology, Jorhat 785006, Assam, India.
Surineni N; Natural Products Chemistry Division, CSIR-North-East Institute of Science & Technology, Jorhat 785006, Assam, India.
Barua NC; Natural Products Chemistry Division, CSIR-North-East Institute of Science & Technology, Jorhat 785006, Assam, India.
Saxena AK; Pharmacology Division, Indian Institute of Integrative Medicine, Jammu 180001, India.
Suri N; Pharmacology Division, Indian Institute of Integrative Medicine, Jammu 180001, India.
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 Jan 01; Vol. 24 (1), pp. 237-9. Date of Electronic Publication: 2013 Nov 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Artemisinins/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Artemisinins/chemical synthesis ; Artemisinins/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dimerization ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; HeLa Cells ; Humans ; MCF-7 Cells ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Synthesis and biological evaluation of trans 6-methoxy-1,1-dimethyl-2-phenyl-3-aryl-2,3-dihydro-1H-inden-4-yloxyalkylamine derivatives against drug susceptible, non-replicating M. tuberculosis H37Rv and clinical multidrug resistant strains.
Autorzy :
Kumar S; Medicinal and Process Chemistry Division, CSIR, Central Drug Research Institute, Lucknow 226001, India. />Dwivedi AP
Kashyap VK
Saxena AK
Dwivedi AK
Srivastava R
Sahu DP
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Apr 15; Vol. 23 (8), pp. 2404-7. Date of Electronic Publication: 2013 Feb 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amines/*chemical synthesis
Amines/*pharmacology
Antitubercular Agents/*chemical synthesis
Antitubercular Agents/*pharmacology
Mycobacterium tuberculosis/*drug effects
Animals ; Drug Resistance, Multiple ; Mice ; Mice, Inbred BALB C ; Microbial Sensitivity Tests
Czasopismo naukowe
Tytuł :
Synthesis of β-ionone derived chalcones as potent antimicrobial agents.
Autorzy :
Sharma V; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
Singh G
Kaur H
Saxena AK
Ishar MP
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Oct 15; Vol. 22 (20), pp. 6343-6. Date of Electronic Publication: 2012 Aug 30.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Infective Agents/*chemistry
Anti-Infective Agents/*pharmacology
Chalcones/*chemistry
Chalcones/*pharmacology
Norisoprenoids/*chemistry
Norisoprenoids/*pharmacology
Anti-Infective Agents/chemical synthesis ; Bacteria/drug effects ; Bacterial Infections/drug therapy ; Chalcones/chemical synthesis ; Fungi/drug effects ; Humans ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Microbial Sensitivity Tests ; Mycoses/drug therapy ; Norisoprenoids/chemical synthesis ; Staphylococcal Infections/drug therapy
Czasopismo naukowe
Tytuł :
Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs.
Autorzy :
Kumar A; Natural Product Microbes Division, Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu Tawi 180 001, India.
Shah BA
Singh S
Hamid A
Singh SK
Sethi VK
Saxena AK
Singh J
Taneja SC
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Jan 01; Vol. 22 (1), pp. 431-5. Date of Electronic Publication: 2011 Nov 09.
Typ publikacji :
Journal Article
MeSH Terms :
NF-kappa B/*metabolism
STAT Transcription Factors/*metabolism
Triterpenes/*pharmacology
Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation ; Drug Design ; Drug Screening Assays, Antitumor/methods ; Flow Cytometry/methods ; HL-60 Cells ; Humans ; Models, Chemical ; Phosphorylation ; Triterpenes/chemistry
Czasopismo naukowe
Tytuł :
Synthesis and 2D QSAR of O-sulphonated β-aminols derivatives as novel antifungal and antibacterial agents.
Autorzy :
Sharma S; Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India.
Pandey AK
Shukla PK
Saxena AK
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Nov 01; Vol. 21 (21), pp. 6476-81. Date of Electronic Publication: 2011 Aug 23.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Alcohols/*chemical synthesis
Amino Alcohols/*pharmacology
Anti-Bacterial Agents/*chemical synthesis
Anti-Bacterial Agents/*pharmacology
Antifungal Agents/*chemical synthesis
Antifungal Agents/*pharmacology
Sulfones/*chemistry
Amino Alcohols/chemistry ; Anti-Bacterial Agents/chemistry ; Antifungal Agents/chemistry ; Inhibitory Concentration 50 ; Microbial Sensitivity Tests ; Quantitative Structure-Activity Relationship ; Regression Analysis
Czasopismo naukowe
Tytuł :
Synthesis and biological evaluation of substituted 4-arylthiazol-2-amino derivatives as potent growth inhibitors of replicating Mycobacterium tuberculosis H₃₇Rv.
Autorzy :
Roy KK; Division of Medicinal and Process Chemistry, Central Drug Research Institute, CSIR, Lucknow 226 001, India.
Singh S
Sharma SK
Srivastava R
Chaturvedi V
Saxena AK
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Sep 15; Vol. 21 (18), pp. 5589-93. Date of Electronic Publication: 2011 Jul 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Mycobacterium tuberculosis/*drug effects
Thiazoles/*pharmacology
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Chemistry Techniques, Synthetic ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests ; Molecular Structure ; Mycobacterium tuberculosis/growth & development ; Stereoisomerism ; Structure-Activity Relationship ; Thiazoles/chemical synthesis ; Thiazoles/chemistry
Czasopismo naukowe
Tytuł :
Synthesis and in vitro cytotoxic evaluation of N-alkylbromo and N-alkylphthalimido-isatins.
Autorzy :
Singh P; Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India.
Kaur S
Kumar V
Bedi PM
Mahajan MP
Sehar I
Pal HC
Saxena AK
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 May 15; Vol. 21 (10), pp. 3017-20. Date of Electronic Publication: 2011 Mar 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemical synthesis
Antineoplastic Agents/*toxicity
Isatin/*chemical synthesis
Isatin/*toxicity
Antineoplastic Agents/chemistry ; Bromine/chemistry ; Cell Line, Tumor ; Cell Survival/drug effects ; HeLa Cells ; Humans ; Inhibitory Concentration 50 ; Isatin/chemistry ; Molecular Structure ; Phthalimides/chemistry
Czasopismo naukowe
Tytuł :
Design, synthesis and docking studies on phenoxy-3-piperazin-1-yl-propan-2-ol derivatives as protein tyrosine phosphatase 1B inhibitors.
Autorzy :
Gupta S; Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226001, India.
Pandey G
Rahuja N
Srivastava AK
Saxena AK
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Oct 01; Vol. 20 (19), pp. 5732-4. Date of Electronic Publication: 2010 Aug 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enzyme Inhibitors/*chemical synthesis
Hypoglycemic Agents/*chemical synthesis
Piperazines/*chemical synthesis
Propanols/*chemistry
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*antagonists & inhibitors
Animals ; Binding Sites ; Catalytic Domain ; Computer Simulation ; Diabetes Mellitus, Experimental/drug therapy ; Disease Models, Animal ; Drug Design ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/therapeutic use ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/therapeutic use ; Piperazine ; Piperazines/chemistry ; Piperazines/therapeutic use ; Propanols/chemical synthesis ; Propanols/therapeutic use ; Protein Structure, Tertiary ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Rats
Czasopismo naukowe
Tytuł :
Substituted hydrazinecarbothioamide as potent antitubercular agents: synthesis and quantitative structure-activity relationship (QSAR).
Autorzy :
Singh S; Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India.
Mandal PK
Singh N
Misra AK
Singh S
Chaturvedi V
Sinha S
Saxena AK
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Apr 15; Vol. 20 (8), pp. 2597-600. Date of Electronic Publication: 2010 Feb 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antitubercular Agents/*chemistry
Antitubercular Agents/*pharmacology
Hydrazines/*chemistry
Hydrazines/*pharmacology
Mycobacterium tuberculosis/*drug effects
Antitubercular Agents/chemical synthesis ; Hydrazines/chemical synthesis ; Microbial Sensitivity Tests ; Quantitative Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Solvent free synthesis, anti-inflammatory and anticancer activity evaluation of tricyclic and tetracyclic benzimidazole derivatives.
Autorzy :
Sondhi SM; Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247 667 UK, India. />Rani R
Singh J
Roy P
Agrawal SK
Saxena AK
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Apr 01; Vol. 20 (7), pp. 2306-10. Date of Electronic Publication: 2010 Feb 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Inflammatory Agents/*chemical synthesis
Anti-Inflammatory Agents/*pharmacology
Antineoplastic Agents/*chemical synthesis
Antineoplastic Agents/*pharmacology
Benzimidazoles/*chemical synthesis
Benzimidazoles/*pharmacology
Neoplasms/*drug therapy
Anti-Inflammatory Agents/chemistry ; Antineoplastic Agents/chemistry ; Benzimidazoles/chemistry ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; Humans ; Microwaves ; Ovarian Neoplasms/drug therapy
Czasopismo naukowe
Tytuł :
Bio-transformation of artemisinin using soil microbe: Direct C-acetoxylation of artemisinin at C-9 by Penicillium simplissimum.
Autorzy :
Goswami A; Natural Products Chemistry Division, North-East Institute of Science & Technology (CSIR), Jorhat 785 006, Assam, India.
Saikia PP
Barua NC
Bordoloi M
Yadav A
Bora TC
Gogoi BK
Saxena AK
Suri N
Sharma M
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Jan 01; Vol. 20 (1), pp. 359-61. Date of Electronic Publication: 2009 Oct 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Soil Microbiology*
Antimalarials/*metabolism
Artemisinins/*metabolism
Penicillium/*metabolism
Soil Pollutants/*metabolism
Antimalarials/chemistry ; Antimalarials/toxicity ; Artemisinins/chemistry ; Artemisinins/toxicity ; Biotransformation ; Cell Line ; Humans ; Magnetic Resonance Spectroscopy ; Soil Pollutants/chemistry ; Soil Pollutants/toxicity ; Spectrometry, Mass, Electrospray Ionization
Czasopismo naukowe
Tytuł :
Synthesis and in vitro study of 14-aryl-14H-dibenzo[a.j]xanthenes as cytotoxic agents.
Autorzy :
Bhattacharya AK; Division of Organic Chemistry and Combi Chem Bio-Resource Centre, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India. ak. />Rana KC
Mujahid M
Sehar I
Saxena AK
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Oct 01; Vol. 19 (19), pp. 5590-3. Date of Electronic Publication: 2009 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytotoxins/*chemical synthesis
Xanthenes/*chemical synthesis
Aldehydes/chemistry ; Catalysis ; Cell Line, Tumor ; Chlorides/chemistry ; Cytotoxins/chemistry ; Cytotoxins/toxicity ; Drug Screening Assays, Antitumor ; Humans ; Naphthols/chemistry ; Tantalum/chemistry ; Xanthenes/chemistry ; Xanthenes/toxicity
Czasopismo naukowe
Tytuł :
Structure-activity relationship (SAR) of parthenin analogues with pro-apoptotic activity: Development of novel anti-cancer leads.
Autorzy :
Shah BA; Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu Tawi 180 001, India. />Kaur R
Gupta P
Kumar A
Sethi VK
Andotra SS
Singh J
Saxena AK
Taneja SC
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Aug 01; Vol. 19 (15), pp. 4394-8. Date of Electronic Publication: 2009 May 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Antineoplastic Agents/*chemical synthesis
Chemistry, Pharmaceutical/*methods
Neoplasms/*drug therapy
Sesquiterpenes/*chemical synthesis
Antineoplastic Agents/pharmacology ; Drug Design ; HL-60 Cells ; HeLa Cells ; Humans ; Inhibitory Concentration 50 ; Models, Chemical ; Plasmids/metabolism ; Sesquiterpenes/pharmacology ; Structure-Activity Relationship ; Telomerase/antagonists & inhibitors ; Topoisomerase II Inhibitors
Czasopismo naukowe
Tytuł :
Synthesis of protein tyrosine phosphatase 1B inhibitors: model validation and docking studies.
Autorzy :
Saxena AK; Central Drug Research Institute, Medicinal and Process Chemistry, Chattar Manzil Palace, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, India. />Pandey G
Gupta S
Singh AB
Srivastava AK
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Apr 15; Vol. 19 (8), pp. 2320-3. Date of Electronic Publication: 2009 Feb 21.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :
Diabetes Mellitus, Experimental/*drug therapy
Drug Delivery Systems/*methods
Hypoglycemic Agents/*chemical synthesis
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*antagonists & inhibitors
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*chemistry
Animals ; Binding Sites/physiology ; Crystallography, X-Ray ; Diabetes Mellitus, Experimental/enzymology ; Hypoglycemic Agents/metabolism ; Hypoglycemic Agents/therapeutic use ; Models, Molecular ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Rats
Czasopismo naukowe
Tytuł :
Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities.
Autorzy :
Sondhi SM; Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, Uttaranchal 247667, India.
Rani R
Roy P
Agrawal SK
Saxena AK
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Mar 01; Vol. 19 (5), pp. 1534-8. Date of Electronic Publication: 2008 Jul 17.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Microwaves*
Anti-Inflammatory Agents, Non-Steroidal/*chemical synthesis
Antineoplastic Agents/*chemical synthesis
Imides/*chemical synthesis
Animals ; Anti-Inflammatory Agents, Non-Steroidal/radiation effects ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Antineoplastic Agents/radiation effects ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Drug Evaluation, Preclinical/methods ; Edema/drug therapy ; Female ; Humans ; Imides/radiation effects ; Imides/therapeutic use ; Male ; Rats
Czasopismo naukowe
Tytuł :
Synthesis and cytotoxic activity of some novel polycyclic gamma-butyrolactones.
Autorzy :
Ishar MP; Bio-Organic and Photochemistry Laboratory, Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143 005, India.
Raj T
Agrawal SK
Saxena AK
Singh L
Singh R
Bhella SS
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Sep 01; Vol. 18 (17), pp. 4809-12. Date of Electronic Publication: 2008 Jul 27.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
4-Butyrolactone/*chemical synthesis
4-Butyrolactone/*toxicity
Growth Inhibitors/*chemical synthesis
Polycyclic Compounds/*chemical synthesis
Polycyclic Compounds/*toxicity
4-Butyrolactone/analogs & derivatives ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/toxicity ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; Growth Inhibitors/toxicity ; Humans ; Male
Czasopismo naukowe
Tytuł :
Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids.
Autorzy :
Shah BA; Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu Tawi 180001, India.
Kumar A
Gupta P
Sharma M
Sethi VK
Saxena AK
Singh J
Qazi GN
Taneja SC
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Dec 01; Vol. 17 (23), pp. 6411-6. Date of Electronic Publication: 2007 Oct 10.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Boswellia*/chemistry
Antineoplastic Agents, Phytogenic/*toxicity
Growth Inhibitors/*toxicity
Triterpenes/*toxicity
Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line, Tumor ; DNA Fragmentation/drug effects ; Humans ; Triterpenes/chemistry
Czasopismo naukowe
Tytuł :
Synthesis and QSAR studies on hypotensive 1-[3-(4-substituted phenylthio) propyl]-4-(substituted phenyl) piperazines.
Autorzy :
Saxena AK; Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India. />Rao J
Chakrabarty R
Saxena M
Srimal RC
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Mar 15; Vol. 17 (6), pp. 1708-12. Date of Electronic Publication: 2006 Dec 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antihypertensive Agents/*chemical synthesis
Antihypertensive Agents/*pharmacology
Piperazines/*chemical synthesis
Piperazines/*pharmacology
Pyrroles/*chemical synthesis
Pyrroles/*pharmacology
Animals ; Blood Pressure/drug effects ; Cats ; Chemical Phenomena ; Chemistry, Physical ; Female ; Indicators and Reagents ; Magnetic Resonance Spectroscopy ; Male ; Mass Spectrometry ; Mice ; NIH 3T3 Cells ; Quantitative Structure-Activity Relationship ; Receptor, Serotonin, 5-HT2A/drug effects ; Spectrophotometry, Infrared
Czasopismo naukowe
Tytuł :
Synthesis and biological activity of amide derivatives of nimbolide.
Autorzy :
Sastry BS; Natural Products Laboratory, Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad.
Suresh Babu K
Hari Babu T
Chandrasekhar S
Srinivas PV
Saxena AK
Madhusudana Rao J
Pokaż więcej
Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Aug 15; Vol. 16 (16), pp. 4391-4. Date of Electronic Publication: 2006 Jun 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amides/*chemistry
Antineoplastic Agents/*pharmacology
Limonins/*chemistry
Azadirachta/metabolism ; Cell Line, Tumor ; Chemistry, Pharmaceutical/methods ; Drug Design ; Humans ; Inhibitory Concentration 50 ; Models, Chemical ; Plant Extracts/metabolism ; Plant Leaves ; Plants, Medicinal/metabolism
Czasopismo naukowe

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