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Wyświetlanie 1-18 z 18
Tytuł :
Vaccine-Mediated Inhibition of the Transporter Associated with Antigen Processing Is Insufficient To Induce Major Histocompatibility Complex E-Restricted CD8(+) T Cells in Nonhuman Primates
Autorzy :
Abdulhaqq, Shaheed A.
Wu, Helen
Schell, John B.
Hammond, Katherine B.
Reed, Jason S.
Legasse, Alfred W.
Axthelm, Michael K.
Park, Byung S.
Asokan, Aravind
Früh, Klaus
Hansen, Scott G.
Picker, Louis J.
Sacha, Jonah B.
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Temat :
Vaccines and Antiviral Agents
Tytuł :
Vaccine-Mediated Inhibition of the Transporter Associated with Antigen Processing Is Insufficient To Induce Major Histocompatibility Complex E-Restricted CD8 T Cells in Nonhuman Primates.
Autorzy :
Abdulhaqq SA; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Wu H; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Schell JB; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Hammond KB; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Reed JS; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Legasse AW; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA.
Axthelm MK; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA.
Park BS; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Asokan A; Department of Surgery, Duke University, Durham, North Carolina, USA.
Früh K; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Hansen SG; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Picker LJ; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Sacha JB; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA .; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA.
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Źródło :
Journal of virology [J Virol] 2019 Sep 12; Vol. 93 (19). Date of Electronic Publication: 2019 Sep 12 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
ATP-Binding Cassette Transporters/*antagonists & inhibitors
CD8-Positive T-Lymphocytes/*immunology
Histocompatibility Antigens Class I/*metabolism
SAIDS Vaccines/*immunology
Simian Immunodeficiency Virus/*immunology
Animals ; Enzyme Inhibitors/metabolism ; Macaca mulatta ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; SAIDS Vaccines/administration & dosage ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/immunology
Czasopismo naukowe
Tytuł :
Combined OX40L and mTOR blockade controls effector T cell activation while preserving T reg reconstitution after transplant.
Autorzy :
Tkachev V; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA 98101, USA. .
Furlan SN; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA.; Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Watkins B; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.; Emory University School of Medicine, Atlanta, GA 30322, USA.
Hunt DJ; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Zheng HB; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Panoskaltsis-Mortari A; Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55454, USA.
Betz K; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Brown M; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Schell JB; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Zeleski K; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Yu A; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Kirby I; Kymab Ltd., Cambridge CB22 3AT, UK.
Cooley S; Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55454, USA.
Miller JS; Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55454, USA.
Blazar BR; Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55454, USA.
Casson D; Kymab Ltd., Cambridge CB22 3AT, UK.
Bland-Ward P; Kymab Ltd., Cambridge CB22 3AT, UK.
Kean LS; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA 98101, USA. .; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA.; Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
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Źródło :
Science translational medicine [Sci Transl Med] 2017 Sep 20; Vol. 9 (408).
Typ publikacji :
Journal Article
MeSH Terms :
Hematopoietic Stem Cell Transplantation*
Lymphocyte Activation/*immunology
OX40 Ligand/*antagonists & inhibitors
T-Lymphocytes, Regulatory/*immunology
TOR Serine-Threonine Kinases/*antagonists & inhibitors
CD11c Antigen/metabolism ; CD3 Complex/metabolism ; Cell Proliferation/drug effects ; Cytokines/metabolism ; Dendritic Cells/drug effects ; Dendritic Cells/metabolism ; Drug Synergism ; Graft vs Host Disease/drug therapy ; Graft vs Host Disease/immunology ; Humans ; Immunity/drug effects ; Lymphocyte Activation/drug effects ; Myeloid Cells/drug effects ; Myeloid Cells/metabolism ; OX40 Ligand/metabolism ; Signal Transduction/drug effects ; Sirolimus/pharmacology ; Sirolimus/therapeutic use ; Survival Analysis ; T-Lymphocytes, Regulatory/drug effects ; TOR Serine-Threonine Kinases/metabolism ; Transcription, Genetic/drug effects ; Transplantation, Homologous ; Up-Regulation/drug effects
Czasopismo naukowe
    Wyświetlanie 1-18 z 18

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