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    Wyświetlanie 1-15 z 15
    Tytuł:
    Vaccination induces HIV broadly neutralizing antibody precursors in humans.
    Autorzy:
    Leggat DJ; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
    Cohen KW; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
    Willis JR; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Fulp WJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
    deCamp AC; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
    Kalyuzhniy O; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Cottrell CA; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Menis S; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Finak G; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
    Ballweber-Fleming L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
    Srikanth A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
    Plyler JR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
    Schiffner T; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Liguori A; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Rahaman F; IAVI, New York, NY 10004, USA.
    Lombardo A; IAVI, New York, NY 10004, USA.
    Philiponis V; IAVI, New York, NY 10004, USA.
    Whaley RE; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
    Seese A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
    Brand J; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
    Ruppel AM; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
    Hoyland W; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
    Yates NL; Center for Human Systems Immunology, Departments of Surgery, Immunology, Molecular Genetics and Microbiology, Duke University, Durham, NC 27701, USA.
    Williams LD; Center for Human Systems Immunology, Departments of Surgery, Immunology, Molecular Genetics and Microbiology, Duke University, Durham, NC 27701, USA.
    Greene K; Duke University Medical Center, Durham, NC 27701, USA.
    Gao H; Duke University Medical Center, Durham, NC 27701, USA.
    Mahoney CR; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
    Corcoran MM; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
    Cagigi A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
    Taylor A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
    Brown DM; The Foundation for the National Institutes of Health, North Bethesda, MD 20852, USA.
    Ambrozak DR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
    Sincomb T; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Hu X; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Tingle R; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Georgeson E; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Eskandarzadeh S; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Alavi N; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Lu D; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Mullen TM; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Kubitz M; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Groschel B; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Maenza J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Department of Medicine, University of Washington, Seattle, WA 98195, USA.
    Kolokythas O; Department of Radiology, University of Washington, Seattle, WA 98195, USA.
    Khati N; Department of Radiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.
    Bethony J; Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.
    Crotty S; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA 92037, USA.
    Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
    Karlsson Hedestam GB; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.; Department of Medicine, University of Washington, Seattle, WA 98195, USA.
    Tomaras GD; Center for Human Systems Immunology, Departments of Surgery, Immunology, Molecular Genetics and Microbiology, Duke University, Durham, NC 27701, USA.
    Montefiori D; Duke University Medical Center, Durham, NC 27701, USA.
    Diemert D; Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.; Department of Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20052, USA.
    Koup RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
    Laufer DS; IAVI, New York, NY 10004, USA.
    McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Department of Medicine, University of Washington, Seattle, WA 98195, USA.
    McDermott AB; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
    Schief WR; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
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    Źródło:
    Science (New York, N.Y.) [Science] 2022 Dec 02; Vol. 378 (6623), pp. eadd6502. Date of Electronic Publication: 2022 Dec 02.
    Typ publikacji:
    Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    AIDS Vaccines*/immunology
    Broadly Neutralizing Antibodies*/genetics
    Broadly Neutralizing Antibodies*/immunology
    HIV Infections*/prevention & control
    HIV Antibodies*/genetics
    HIV Antibodies*/immunology
    Germ Cells*/immunology
    Immunoglobulin Light Chains*/genetics
    Immunoglobulin Light Chains*/immunology
    Immunoglobulin Heavy Chains*/genetics
    Immunoglobulin Heavy Chains*/immunology
    Humans ; Adjuvants, Immunologic ; Vaccination ; B-Lymphocytes/immunology ; Mutation ; Male ; Female ; Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses.
    Autorzy:
    Steichen JM; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Lin YC; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
    Havenar-Daughton C; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
    Pecetta S; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
    Ozorowski G; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Willis JR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Toy L; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
    Sok D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Liguori A; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Kratochvil S; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
    Torres JL; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Kalyuzhniy O; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Melzi E; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
    Kulp DW; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Vaccine and Immune Therapy Center, The Wistar Institute, Philadelphia, PA 19104, USA.
    Raemisch S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Hu X; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Bernard SM; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Georgeson E; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Phelps N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Adachi Y; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Kubitz M; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Landais E; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Umotoy J; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Robinson A; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Briney B; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for Viral Systems Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Wilson IA; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Ward AB; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Crotty S; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA. schief@scripps.edu .; Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.
    Batista FD; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA. schief@scripps.edu .; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.
    Schief WR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA. schief@scripps.edu .; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
    Pokaż więcej
    Źródło:
    Science (New York, N.Y.) [Science] 2019 Dec 06; Vol. 366 (6470). Date of Electronic Publication: 2019 Oct 31.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Immunogenicity, Vaccine*
    AIDS Vaccines/*genetics
    AIDS Vaccines/*immunology
    Broadly Neutralizing Antibodies/*immunology
    Directed Molecular Evolution/*methods
    HIV Antibodies/*immunology
    env Gene Products, Human Immunodeficiency Virus/*genetics
    env Gene Products, Human Immunodeficiency Virus/*immunology
    Adoptive Transfer ; Amino Acid Sequence ; Animals ; B-Lymphocytes/immunology ; Broadly Neutralizing Antibodies/chemistry ; Complementarity Determining Regions/immunology ; Disease Models, Animal ; HEK293 Cells ; HIV Antibodies/chemistry ; Humans ; Mice ; Mice, Knockout ; Precursor Cells, B-Lymphoid/immunology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes.
    Autorzy:
    Tokatlian T; Koch Institute, MIT, Massachusetts, USA.
    Kulp DW; International AIDS Vaccine Initiative, New York, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, California, USA.; Vaccine and Immunotherapy Center, The Wistar Institute, Pennsylvania, USA.
    Mutafyan AA; Koch Institute, MIT, Massachusetts, USA.
    Jones CA; Koch Institute, MIT, Massachusetts, USA.
    Menis S; International AIDS Vaccine Initiative, New York, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, California, USA.
    Georgeson E; International AIDS Vaccine Initiative, New York, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, California, USA.
    Kubitz M; International AIDS Vaccine Initiative, New York, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, California, USA.
    Zhang MH; Koch Institute, MIT, Massachusetts, USA.
    Melo MB; Koch Institute, MIT, Massachusetts, USA.
    Silva M; Koch Institute, MIT, Massachusetts, USA.
    Yun DS; Koch Institute, MIT, Massachusetts, USA.
    Schief WR; International AIDS Vaccine Initiative, New York, USA.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, California, USA.; Immunology and Microbial Science, TSRI, California, USA.; Ragon Institute of MGH, MIT, and Harvard, Massachusetts, USA.
    Irvine DJ; Koch Institute, MIT, Massachusetts, USA. .; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, California, USA. .; Department of Biological Engineering and Materials Science & Engineering, MIT, Massachusetts, USA. .; Ragon Institute of MGH, MIT, and Harvard, Massachusetts, USA. .; Howard Hughes Medical Institute, Maryland, USA. .
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    Źródło:
    Scientific reports [Sci Rep] 2018 Nov 08; Vol. 8 (1), pp. 16527. Date of Electronic Publication: 2018 Nov 08.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antibodies, Neutralizing/*blood
    Germinal Center/*immunology
    HIV Antibodies/*blood
    env Gene Products, Human Immunodeficiency Virus/*administration & dosage
    AIDS Vaccines/administration & dosage ; AIDS Vaccines/chemistry ; AIDS Vaccines/immunology ; Animals ; Antibody Formation ; Cell Line ; Cryoelectron Microscopy ; Drug Design ; Drug Stability ; Humans ; Immunity, Humoral ; Immunization ; Liposomes ; Mice ; Nanoparticles ; env Gene Products, Human Immunodeficiency Virus/chemistry ; env Gene Products, Human Immunodeficiency Virus/immunology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.
    Autorzy:
    Irimia A; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.
    Serra AM; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.
    Sarkar A; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.
    Jacak R; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.; Applied Physics Laboratory, Johns Hopkins University, Baltimore, Maryland, United States of America.
    Kalyuzhniy O; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.
    Sok D; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.
    Saye-Francisco KL; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.
    Schiffner T; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.
    Tingle R; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.
    Kubitz M; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.
    Adachi Y; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.
    Stanfield RL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.
    Deller MC; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
    Burton DR; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
    Schief WR; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
    Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.
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    Źródło:
    PLoS pathogens [PLoS Pathog] 2017 Feb 22; Vol. 13 (2), pp. e1006212. Date of Electronic Publication: 2017 Feb 22 (Print Publication: 2017).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Antibodies, Neutralizing/*chemistry
    Antibodies, Neutralizing/*immunology
    HIV Antibodies/*chemistry
    HIV Antibodies/*immunology
    HIV-1/*immunology
    Antibodies, Blocking/chemistry ; Antibodies, Blocking/immunology ; HIV Envelope Protein gp41/immunology ; Humans ; Protein Conformation ; Surface Plasmon Resonance ; X-Ray Diffraction
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice.
    Autorzy:
    Sok D; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Briney B; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Jardine JG; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Kulp DW; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Menis S; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Pauthner M; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Wood A; Kymab Ltd, The Bennet Building (B930), Babraham Research Campus, Cambridge CB22 3AT, UK.
    Lee EC; Kymab Ltd, The Bennet Building (B930), Babraham Research Campus, Cambridge CB22 3AT, UK.
    Le KM; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Jones M; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Ramos A; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Kalyuzhniy O; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Adachi Y; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Kubitz M; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    MacPherson S; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Bradley A; Kymab Ltd, The Bennet Building (B930), Babraham Research Campus, Cambridge CB22 3AT, UK. Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
    Friedrich GA; Kymab Ltd, The Bennet Building (B930), Babraham Research Campus, Cambridge CB22 3AT, UK.
    Schief WR; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Ragon Institute of Massachusetts General Hospital (MGH), MIT, and Harvard, Cambridge, MA 02129, USA. schief@scripps.edu.
    Burton DR; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Ragon Institute of Massachusetts General Hospital (MGH), MIT, and Harvard, Cambridge, MA 02129, USA. schief@scripps.edu.
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    Źródło:
    Science (New York, N.Y.) [Science] 2016 Sep 30; Vol. 353 (6307), pp. 1557-1560. Date of Electronic Publication: 2016 Sep 08.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
    MeSH Terms:
    AIDS Vaccines/*immunology
    Antibodies, Monoclonal/*immunology
    Antibodies, Neutralizing/*immunology
    Genes, Immunoglobulin Heavy Chain/*immunology
    HIV Antibodies/*immunology
    HIV-1/*immunology
    Precursor Cells, B-Lymphoid/*immunology
    Animals ; Antibodies, Blocking/immunology ; Antibodies, Monoclonal/genetics ; Broadly Neutralizing Antibodies ; Genes, Immunoglobulin Heavy Chain/genetics ; Genetic Loci ; Germ Cells/immunology ; Humans ; Immunization ; Immunologic Memory ; Mice ; Mice, Transgenic ; Nanoparticles ; Protein Domains/genetics ; Protein Domains/immunology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.
    Autorzy:
    Jardine JG; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Biochemistry, University of Washington, Seattle, Washington, United States of America.
    Sok D; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; International AIDS Vaccine Initiative, New York, New York, United States of America.
    Julien JP; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.; Program in Molecular Structure and Function, The Hospital for Sick Children Research Institute and Departments of Biochemistry and Immunology, University of Toronto, Toronto, Ontario, Canada.
    Briney B; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.
    Sarkar A; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
    Liang CH; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.
    Scherer EA; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
    Henry Dunand CJ; Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois, United States of America.
    Adachi Y; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Biochemistry, University of Washington, Seattle, Washington, United States of America.
    Diwanji D; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
    Hsueh J; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.
    Jones M; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Biochemistry, University of Washington, Seattle, Washington, United States of America.
    Kalyuzhniy O; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Biochemistry, University of Washington, Seattle, Washington, United States of America.
    Kubitz M; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.
    Spencer S; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Biochemistry, University of Washington, Seattle, Washington, United States of America.
    Pauthner M; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.
    Saye-Francisco KL; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.
    Sesterhenn F; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.
    Wilson PC; Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois, United States of America.
    Galloway DM; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
    Stanfield RL; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
    Wilson IA; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America.
    Burton DR; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, United States of America.
    Schief WR; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.; Department of Biochemistry, University of Washington, Seattle, Washington, United States of America.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, United States of America.
    Pokaż więcej
    Źródło:
    PLoS pathogens [PLoS Pathog] 2016 Aug 25; Vol. 12 (8), pp. e1005815. Date of Electronic Publication: 2016 Aug 25 (Print Publication: 2016).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Drug Design*
    AIDS Vaccines/*immunology
    Antibodies, Neutralizing/*immunology
    HIV Antibodies/*immunology
    HIV-1/*immunology
    Amino Acid Sequence ; Antibodies, Neutralizing/genetics ; HIV Antibodies/genetics ; HIV Infections/immunology ; High-Throughput Screening Assays ; Humans ; Models, Molecular ; Mutation
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.
    Autorzy:
    Jardine JG; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Kulp DW; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Havenar-Daughton C; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
    Sarkar A; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Briney B; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Sok D; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Sesterhenn F; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Ereño-Orbea J; Program in Molecular Structure and Function, Hospital for Sick Children Research Institute, Toronto, Ontario M5G 0A4, Canada.
    Kalyuzhniy O; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Deresa I; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
    Hu X; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Spencer S; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Jones M; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Georgeson E; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Adachi Y; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Kubitz M; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    deCamp AC; Vaccine and Infectious Disease Division, Statistical Center for HIV/AIDS Research and Prevention (SCHARP), Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
    Julien JP; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Program in Molecular Structure and Function, Hospital for Sick Children Research Institute, Toronto, Ontario M5G 0A4, Canada. Departments of Biochemistry and Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
    Wilson IA; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Burton DR; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02129, USA.
    Crotty S; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. Division of Infectious Diseases, Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USA. schief@scripps.edu .
    Schief WR; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02129, USA. schief@scripps.edu .
    Pokaż więcej
    Źródło:
    Science (New York, N.Y.) [Science] 2016 Mar 25; Vol. 351 (6280), pp. 1458-63.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    AIDS Vaccines/*immunology
    Antibodies, Monoclonal/*immunology
    Antibodies, Neutralizing/*immunology
    Epitopes, B-Lymphocyte/*immunology
    Germ Cells/*immunology
    HIV Antibodies/*immunology
    HIV-1/*immunology
    Precursor Cells, B-Lymphoid/*immunology
    Amino Acid Sequence ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/isolation & purification ; Antibody Affinity ; B-Lymphocytes/immunology ; Broadly Neutralizing Antibodies ; Cell Separation ; Combinatorial Chemistry Techniques ; Epitopes, B-Lymphocyte/chemistry ; Epitopes, B-Lymphocyte/genetics ; HIV Antibodies/chemistry ; HIV Antibodies/isolation & purification ; Humans ; Molecular Sequence Data ; Mutation ; Peptide Library ; Protein Conformation
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers.
    Autorzy:
    Sanders RW; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA. Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, Netherlands. .
    van Gils MJ; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, Netherlands.
    Derking R; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, Netherlands.
    Sok D; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative, Neutralizing Antibody Center, and Collaboration for AIDS Vaccine Discovery, Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA.
    Ketas TJ; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA.
    Burger JA; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, Netherlands.
    Ozorowski G; International AIDS Vaccine Initiative, Neutralizing Antibody Center, and Collaboration for AIDS Vaccine Discovery, Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA. Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
    Cupo A; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA.
    Simonich C; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
    Goo L; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
    Arendt H; International AIDS Vaccine Initiative, New York, NY 10004, USA.
    Kim HJ; International AIDS Vaccine Initiative, Neutralizing Antibody Center, and Collaboration for AIDS Vaccine Discovery, Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA. Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
    Lee JH; International AIDS Vaccine Initiative, Neutralizing Antibody Center, and Collaboration for AIDS Vaccine Discovery, Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA. Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
    Pugach P; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA.
    Williams M; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA.
    Debnath G; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA.
    Moldt B; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative, Neutralizing Antibody Center, and Collaboration for AIDS Vaccine Discovery, Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA.
    van Breemen MJ; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, Netherlands.
    Isik G; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, Netherlands.
    Medina-Ramírez M; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, Netherlands.
    Back JW; Pepscan Therapeutics, 8243RC Lelystad, Netherlands.
    Koff WC; International AIDS Vaccine Initiative, New York, NY 10004, USA.
    Julien JP; International AIDS Vaccine Initiative, Neutralizing Antibody Center, and Collaboration for AIDS Vaccine Discovery, Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA. Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
    Rakasz EG; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA.
    Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Boston, MA 02114, USA.
    Guttman M; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.
    Lee KK; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.
    Klasse PJ; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA.
    LaBranche C; Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
    Schief WR; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative, Neutralizing Antibody Center, and Collaboration for AIDS Vaccine Discovery, Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative, New York, NY 10004, USA. Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Boston, MA 02114, USA.
    Wilson IA; International AIDS Vaccine Initiative, Neutralizing Antibody Center, and Collaboration for AIDS Vaccine Discovery, Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA. Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA. Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
    Overbaugh J; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
    Burton DR; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative, Neutralizing Antibody Center, and Collaboration for AIDS Vaccine Discovery, Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA. Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Boston, MA 02114, USA.
    Ward AB; International AIDS Vaccine Initiative, Neutralizing Antibody Center, and Collaboration for AIDS Vaccine Discovery, Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA. Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
    Montefiori DC; Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
    Dean H; International AIDS Vaccine Initiative, New York, NY 10004, USA.
    Moore JP; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA. .
    Pokaż więcej
    Źródło:
    Science (New York, N.Y.) [Science] 2015 Jul 10; Vol. 349 (6244), pp. aac4223. Date of Electronic Publication: 2015 Jun 18.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    AIDS Vaccines/*immunology
    Antibodies, Neutralizing/*immunology
    HIV Antibodies/*immunology
    HIV Infections/*prevention & control
    HIV-1/*immunology
    env Gene Products, Human Immunodeficiency Virus/*immunology
    Animals ; Cross Reactions ; Epitopes/immunology ; Humans ; Macaca ; Protein Engineering ; Protein Multimerization ; Rabbits ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; env Gene Products, Human Immunodeficiency Virus/chemistry ; env Gene Products, Human Immunodeficiency Virus/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.
    Autorzy:
    Jardine JG; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center (NAC), The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Ota T; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Sok D; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center (NAC), The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Pauthner M; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center (NAC), The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Kulp DW; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center (NAC), The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Kalyuzhniy O; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center (NAC), The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Skog PD; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Thinnes TC; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Bhullar D; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Briney B; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center (NAC), The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Menis S; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center (NAC), The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Jones M; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center (NAC), The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Kubitz M; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center (NAC), The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Spencer S; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center (NAC), The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Adachi Y; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center (NAC), The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
    Burton DR; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center (NAC), The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02129, USA. schief@scripps.edu .
    Schief WR; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center (NAC), The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02129, USA. schief@scripps.edu .
    Nemazee D; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. schief@scripps.edu .
    Pokaż więcej
    Źródło:
    Science (New York, N.Y.) [Science] 2015 Jul 10; Vol. 349 (6244), pp. 156-61. Date of Electronic Publication: 2015 Jun 18.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    AIDS Vaccines/*immunology
    Antibodies, Monoclonal/*immunology
    Antibodies, Neutralizing/*immunology
    HIV Antibodies/*immunology
    HIV Envelope Protein gp120/*immunology
    HIV Infections/*prevention & control
    HIV-1/*immunology
    Animals ; Antibodies, Monoclonal/biosynthesis ; Antibodies, Neutralizing/biosynthesis ; Antibody Affinity ; B-Lymphocytes/immunology ; Broadly Neutralizing Antibodies ; Complementarity Determining Regions/genetics ; Complementarity Determining Regions/immunology ; Epitopes/genetics ; Epitopes/immunology ; HIV Antibodies/biosynthesis ; HIV Envelope Protein gp120/genetics ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Heavy Chains/immunology ; Mice ; Mice, Knockout
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site.
    Autorzy:
    Crooks ET; San Diego Biomedical Research Institute, San Diego, California, United States of America.
    Tong T; San Diego Biomedical Research Institute, San Diego, California, United States of America.
    Chakrabarti B; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center at The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, California, United States of America.
    Narayan K; Altravax, Inc., Sunnyvale, California, United States of America.
    Georgiev IS; Vaccine Research Center, National Institutes of Health (NIH), Bethesda, Maryland, United States of America.
    Menis S; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center at The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, California, United States of America; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.
    Huang X; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing, China.
    Kulp D; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center at The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, California, United States of America; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.
    Osawa K; San Diego Biomedical Research Institute, San Diego, California, United States of America.
    Muranaka J; Altravax, Inc., Sunnyvale, California, United States of America.
    Stewart-Jones G; Vaccine Research Center, National Institutes of Health (NIH), Bethesda, Maryland, United States of America; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe Hospital, Oxford, United Kingdom.
    Destefano J; International AIDS Vaccine Initiative, Design and Development Laboratory, Brooklyn, New York, United States of America.
    O'Dell S; Vaccine Research Center, National Institutes of Health (NIH), Bethesda, Maryland, United States of America.
    LaBranche C; Department of Surgery, Duke University, Duke University Medical Center, Durham, North Carolina, United States of America.
    Robinson JE; Tulane National Primate Research Center, Covington, Louisiana, United States of America.
    Montefiori DC; Department of Surgery, Duke University, Duke University Medical Center, Durham, North Carolina, United States of America.
    McKee K; Vaccine Research Center, National Institutes of Health (NIH), Bethesda, Maryland, United States of America.
    Du SX; Altravax, Inc., Sunnyvale, California, United States of America.
    Doria-Rose N; Vaccine Research Center, National Institutes of Health (NIH), Bethesda, Maryland, United States of America.
    Kwong PD; Vaccine Research Center, National Institutes of Health (NIH), Bethesda, Maryland, United States of America.
    Mascola JR; Vaccine Research Center, National Institutes of Health (NIH), Bethesda, Maryland, United States of America.
    Zhu P; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing, China.
    Schief WR; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center at The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, California, United States of America; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, United States of America.
    Wyatt RT; International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center at The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, California, United States of America; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America.
    Whalen RG; Altravax, Inc., Sunnyvale, California, United States of America.
    Binley JM; San Diego Biomedical Research Institute, San Diego, California, United States of America.
    Pokaż więcej
    Źródło:
    PLoS pathogens [PLoS Pathog] 2015 May 29; Vol. 11 (5), pp. e1004932. Date of Electronic Publication: 2015 May 29 (Print Publication: 2015).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    AIDS Vaccines/*immunology
    Antibodies, Monoclonal/*immunology
    Antibodies, Neutralizing/*immunology
    CD4 Antigens/*metabolism
    Epitopes/*immunology
    HIV Antibodies/*immunology
    HIV Envelope Protein gp120/*metabolism
    HIV-1/*immunology
    Polysaccharides/*deficiency
    Animals ; Binding Sites ; CD4 Antigens/genetics ; Epitopes/chemistry ; Female ; Guinea Pigs ; HIV Envelope Protein gp120/chemistry ; HIV Envelope Protein gp120/genetics ; HIV Envelope Protein gp120/immunology ; HIV Infections/immunology ; HIV Infections/virology ; Humans ; Immunization ; Polysaccharides/chemistry ; Polysaccharides/genetics ; Protein Conformation ; Rabbits
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.
    Autorzy:
    Pejchal R; Department of Molecular Biology, Skaggs Institute for Chemical Biology and International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, nhe Scripps Research Institute, La Jolla, CA 92037, USA.
    Doores KJ
    Walker LM
    Khayat R
    Huang PS
    Wang SK
    Stanfield RL
    Julien JP
    Ramos A
    Crispin M
    Depetris R
    Katpally U
    Marozsan A
    Cupo A
    Maloveste S
    Liu Y
    McBride R
    Ito Y
    Sanders RW
    Ogohara C
    Paulson JC
    Feizi T
    Scanlan CN
    Wong CH
    Moore JP
    Olson WC
    Ward AB
    Poignard P
    Schief WR
    Burton DR
    Wilson IA
    Pokaż więcej
    Źródło:
    Science (New York, N.Y.) [Science] 2011 Nov 25; Vol. 334 (6059), pp. 1097-103. Date of Electronic Publication: 2011 Oct 13.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Antibodies, Neutralizing/*immunology
    HIV Antibodies/*immunology
    HIV Antibodies/*metabolism
    HIV Envelope Protein gp120/*immunology
    HIV-1/*immunology
    Oligosaccharides/*immunology
    Polysaccharides/*immunology
    Polysaccharides/*metabolism
    Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/genetics ; Antibodies, Neutralizing/metabolism ; Antibody Specificity ; Binding Sites, Antibody ; Carbohydrate Conformation ; Cell Line ; Crystallography, X-Ray ; Disaccharides/chemistry ; Disaccharides/metabolism ; Epitopes ; Glycosylation ; HIV Antibodies/chemistry ; HIV Antibodies/genetics ; HIV Envelope Protein gp120/chemistry ; HIV Envelope Protein gp120/metabolism ; HIV-1/physiology ; Humans ; Hydrogen Bonding ; Immunoglobulin Fab Fragments/chemistry ; Immunoglobulin Fab Fragments/immunology ; Immunoglobulin Fab Fragments/metabolism ; Mannose/chemistry ; Mannose/immunology ; Mannose/metabolism ; Mannosides/chemistry ; Mannosides/metabolism ; Models, Molecular ; Mutation ; Oligosaccharides/chemistry ; Oligosaccharides/metabolism ; Polysaccharides/chemistry ; Protein Conformation ; Protein Structure, Tertiary
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
    Autorzy:
    McLellan JS; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
    Pancera M
    Carrico C
    Gorman J
    Julien JP
    Khayat R
    Louder R
    Pejchal R
    Sastry M
    Dai K
    O'Dell S
    Patel N
    Shahzad-ul-Hussan S
    Yang Y
    Zhang B
    Zhou T
    Zhu J
    Boyington JC
    Chuang GY
    Diwanji D
    Georgiev I
    Kwon YD
    Lee D
    Louder MK
    Moquin S
    Schmidt SD
    Yang ZY
    Bonsignori M
    Crump JA
    Kapiga SH
    Sam NE
    Haynes BF
    Burton DR
    Koff WC
    Walker LM
    Phogat S
    Wyatt R
    Orwenyo J
    Wang LX
    Arthos J
    Bewley CA
    Mascola JR
    Nabel GJ
    Schief WR
    Ward AB
    Wilson IA
    Kwong PD
    Pokaż więcej
    Źródło:
    Nature [Nature] 2011 Nov 23; Vol. 480 (7377), pp. 336-43. Date of Electronic Publication: 2011 Nov 23.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Antibodies, Neutralizing/*immunology
    Antibody Specificity/*immunology
    HIV Antibodies/*immunology
    HIV Envelope Protein gp120/*chemistry
    HIV Envelope Protein gp120/*immunology
    HIV-1/*chemistry
    HIV-1/*immunology
    AIDS Vaccines/chemistry ; AIDS Vaccines/immunology ; Amino Acid Motifs ; Amino Acid Sequence ; Antibodies, Neutralizing/chemistry ; Antibody Affinity/immunology ; Antigen-Antibody Complex/chemistry ; Antigen-Antibody Complex/immunology ; Binding Sites, Antibody/immunology ; Conserved Sequence ; Crystallography, X-Ray ; Epitopes/chemistry ; Epitopes/immunology ; Glycopeptides/chemistry ; Glycopeptides/immunology ; Glycosylation ; HIV Antibodies/chemistry ; Hydrogen Bonding ; Immune Evasion ; Models, Molecular ; Molecular Sequence Data ; Polysaccharides/chemistry ; Polysaccharides/immunology ; Protein Structure, Quaternary ; Protein Structure, Tertiary
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Heterologous epitope-scaffold prime:boosting immuno-focuses B cell responses to the HIV-1 gp41 2F5 neutralization determinant.
    Autorzy:
    Guenaga J; Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, United States of America.
    Dosenovic P
    Ofek G
    Baker D
    Schief WR
    Kwong PD
    Karlsson Hedestam GB
    Wyatt RT
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2011 Jan 26; Vol. 6 (1), pp. e16074. Date of Electronic Publication: 2011 Jan 26.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antibodies, Neutralizing/*immunology
    B-Lymphocytes/*immunology
    Epitopes/*immunology
    HIV Antibodies/*immunology
    HIV Envelope Protein gp41/*immunology
    HIV-1/*immunology
    Humans ; Immunization, Secondary
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1.
    Autorzy:
    Wu X; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
    Yang ZY
    Li Y
    Hogerkorp CM
    Schief WR
    Seaman MS
    Zhou T
    Schmidt SD
    Wu L
    Xu L
    Longo NS
    McKee K
    O'Dell S
    Louder MK
    Wycuff DL
    Feng Y
    Nason M
    Doria-Rose N
    Connors M
    Kwong PD
    Roederer M
    Wyatt RT
    Nabel GJ
    Mascola JR
    Pokaż więcej
    Źródło:
    Science (New York, N.Y.) [Science] 2010 Aug 13; Vol. 329 (5993), pp. 856-61. Date of Electronic Publication: 2010 Jul 08.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antibodies, Monoclonal/*immunology
    Antibodies, Neutralizing/*immunology
    HIV Antibodies/*immunology
    HIV Envelope Protein gp120/*immunology
    HIV-1/*immunology
    AIDS Vaccines ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Neutralizing/isolation & purification ; Antibody Specificity ; B-Lymphocytes/immunology ; Binding Sites, Antibody ; CD4 Antigens/immunology ; CD4 Antigens/metabolism ; Cross Reactions ; Drug Design ; Enzyme-Linked Immunosorbent Assay ; Epitopes/immunology ; Genes, Immunoglobulin Heavy Chain ; Genes, Immunoglobulin Light Chain ; HIV Antibodies/isolation & purification ; HIV Envelope Protein gp120/chemistry ; HIV Envelope Protein gp120/metabolism ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/genetics ; Humans ; Molecular Sequence Data ; Neutralization Tests ; Protein Engineering ; Recombinant Proteins/chemistry ; Recombinant Proteins/immunology ; Recombinant Proteins/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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