- Tytuł:
- Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.
- Autorzy:
- Źródło:
- Science (New York, N.Y.) [Science] 2021 Feb 12; Vol. 371 (6530). Date of Electronic Publication: 2021 Jan 12.
- Typ publikacji:
- Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
COVID-19/*immunology
SARS-CoV-2/*immunology
Single-Domain Antibodies/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Amino Acid Substitution ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/metabolism ; Antibodies, Viral/chemistry ; Antibodies, Viral/metabolism ; Antibody Affinity ; Antigens, Viral/immunology ; Binding Sites, Antibody ; COVID-19/virology ; Cell Line ; Cryoelectron Microscopy ; Epitopes ; Humans ; Membrane Fusion ; Mutation ; Protein Binding ; Protein Conformation ; Protein Domains ; Receptors, Coronavirus/metabolism ; SARS-CoV-2/genetics ; SARS-CoV-2/physiology ; Single-Domain Antibodies/chemistry ; Single-Domain Antibodies/metabolism ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Replication
Czasopismo naukowe