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Tytuł:
Exosome mimetics: a novel class of drug delivery systems
Autorzy:
Kooijmans SAA
Vader P
van Dommelen SM
van Solinge WW
Schiffelers RM
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Temat:
Medicine (General)
R5-920
Źródło:
International Journal of Nanomedicine, Vol 2012, Iss default, Pp 1525-1541 (2012)
Opis pliku:
electronic resource
Relacje:
http://www.dovepress.com/exosome-mimetics-a-novel-class-of-drug-delivery-systems-a9513; https://doaj.org/toc/1176-9114; https://doaj.org/toc/1178-2013
Dostęp URL:
https://doaj.org/article/584cda0c72fa45f6ab0b71f495c42d42  Link otwiera się w nowym oknie
Czasopismo naukowe
Szczegóły
Tytuł:
Modular nanotransporters: a multipurpose in vivo working platform for targeted drug delivery
Autorzy:
Slastnikova TA
Rosenkranz AA
Gulak PV
Schiffelers RM
Lupanova TN
Khramtsov YV
Zalutsky MR
Sobolev AS
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Temat:
Medicine (General)
R5-920
Źródło:
International Journal of Nanomedicine, Vol 2012, Iss default, Pp 467-482 (2012)
Opis pliku:
electronic resource
Relacje:
http://www.dovepress.com/modular-nanotransporters-a-multipurpose-in-vivo-working-platform-for-t-a9198; https://doaj.org/toc/1176-9114; https://doaj.org/toc/1178-2013
Dostęp URL:
https://doaj.org/article/981d98348d6d4b7085f50fc12ef4a100  Link otwiera się w nowym oknie
Czasopismo naukowe
Szczegóły
Tytuł:
A polymeric colchicinoid prodrug with reduced toxicity and improved efficacy for vascular disruption in cancer therapy
Autorzy:
Crielaard BJ
van der Wal S
Lammers T
Le HT
Hennink WE
Schiffelers RM
Storm G
Fens MHAM
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Temat:
Medicine (General)
R5-920
Źródło:
International Journal of Nanomedicine, Vol 2011, Iss default, Pp 2697-2703 (2011)
Opis pliku:
electronic resource
Relacje:
http://www.dovepress.com/a-polymeric-colchicinoid-prodrug-with-reduced-toxicity-and-improved-ef-a8587; https://doaj.org/toc/1176-9114; https://doaj.org/toc/1178-2013
Dostęp URL:
https://doaj.org/article/35c8a337cef54e64bf896ec89bc1248a  Link otwiera się w nowym oknie
Czasopismo naukowe
Szczegóły
Tytuł:
Extracellular vesicle-mediated delivery of CRISPR/Cas9 ribonucleoprotein complex targeting proprotein convertase subtilisin-kexin type 9 (Pcsk9) in primary mouse hepatocytes.
Autorzy:
Ilahibaks NF; Laboratory of Experimental Cardiology, Department Heart & Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
Kluiver TA; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
de Jong OG; Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherland.
de Jager SCA; Laboratory of Experimental Cardiology, Department Heart & Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
Schiffelers RM; CDL Research, University Medical Center Utrecht, Utrecht, The Netherlands.
Vader P; Laboratory of Experimental Cardiology, Department Heart & Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.; CDL Research, University Medical Center Utrecht, Utrecht, The Netherlands.
Peng WC; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Lei Z; Laboratory of Experimental Cardiology, Department Heart & Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.; CDL Research, University Medical Center Utrecht, Utrecht, The Netherlands.
Sluijter JPG; Laboratory of Experimental Cardiology, Department Heart & Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.; Circulatory Health Laboratory, Regenerative Medicine Center, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands.
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Źródło:
Journal of extracellular vesicles [J Extracell Vesicles] 2024 Jan; Vol. 13 (1), pp. e12389.
Typ publikacji:
Journal Article
MeSH Terms:
Extracellular Vesicles*
Animals ; Mice ; Cholesterol, LDL ; CRISPR-Cas Systems ; Hepatocytes ; Proprotein Convertase 9/genetics ; Subtilisins ; Tacrolimus Binding Protein 1A
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Increased Bone Marrow Uptake and Accumulation of Very-Late Antigen-4 Targeted Lipid Nanoparticles.
Autorzy:
Swart LE; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands.
Fens MHAM; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands.
van Oort A; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands.
Waranecki P; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands.
Mata Casimiro LD; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands.
Tuk D; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands.
Hendriksen M; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands.
van den Brink L; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands.
Schweighart E; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands.
Seinen C; CDL Research, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Nelson R; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands.
Krippner-Heidenreich A; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands.
O'Toole T; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands.
Schiffelers RM; CDL Research, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Kooijmans S; CDL Research, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Heidenreich O; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands.; Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle upon Tyne NE1 7RY, UK.
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Źródło:
Pharmaceutics [Pharmaceutics] 2023 May 27; Vol. 15 (6). Date of Electronic Publication: 2023 May 27.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Extracellular vesicles enclosed-miR-421 suppresses air pollution (PM 2.5 )-induced cardiac dysfunction via ACE2 signalling.
Autorzy:
Wang H; Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai, China.
Wang T; Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai, China.
Rui W; Institute for Immunology, Tsinghua University, Beijing, China.
Xie J; Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai, China.
Xie Y; Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai, China.
Zhang X; Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai, China.
Guan L; China-America Institute Neuroscience, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Li G; Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Lei Z; CDL Research, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Cardiology, Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.; UMC Utrecht Regenerative Medicine Center, University Medical Center, Utrecht University, Utrecht, The Netherlands.
Schiffelers RM; CDL Research, University Medical Center Utrecht, Utrecht, The Netherlands.
Sluijter JPG; Department of Cardiology, Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.; UMC Utrecht Regenerative Medicine Center, University Medical Center, Utrecht University, Utrecht, The Netherlands.
Xiao J; Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai, China.
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Źródło:
Journal of extracellular vesicles [J Extracell Vesicles] 2022 May; Vol. 11 (5), pp. e12222.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Air Pollution*/analysis
Extracellular Vesicles*
Heart Diseases*
Lung Injury*
MicroRNAs*
Angiotensin-Converting Enzyme 2 ; Animals ; Mice ; Myocytes, Cardiac ; Particulate Matter/adverse effects ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept Studies.
Autorzy:
Connor K; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Murray DW; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Jarzabek MA; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Tran NL; Department of Cancer Biology and Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ 85054, USA.
White K; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Dicker P; Epidemiology & Public Health, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Sweeney KJ; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.; National Neurosurgical Department, Beaumont Hospital, Dublin 9, Ireland.
O'Halloran PJ; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.; National Neurosurgical Department, Beaumont Hospital, Dublin 9, Ireland.
MacCarthy B; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Shiels LP; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Lodi F; Center for Cancer Biology, Laboratory for Translational Genetics, Vlaams Instituut voor Biotechnologie (VIB), B-3000 Leuven, Belgium.
Lambrechts D; Center for Cancer Biology, Laboratory for Translational Genetics, Vlaams Instituut voor Biotechnologie (VIB), B-3000 Leuven, Belgium.
Sarkaria JN; Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Schiffelers RM; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, 100 3584 Utrecht, The Netherlands.
Symons M; Department of Oncology & Cell Biology, Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, NY 11030, USA.
Byrne AT; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
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Źródło:
Cancers [Cancers (Basel)] 2020 Nov 26; Vol. 12 (12). Date of Electronic Publication: 2020 Nov 26.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cellular and Molecular Mechanism of Cardiac Regeneration: A Comparison of Newts, Zebrafish, and Mammals.
Autorzy:
de Wit L; Department of Cardiology, Experimental Cardiology Laboratory, UMC Utrecht, 3584CX Utrecht, The Netherlands.
Fang J; Department of Cardiology, Experimental Cardiology Laboratory, UMC Utrecht, 3584CX Utrecht, The Netherlands.
Neef K; Department of Cardiology, Experimental Cardiology Laboratory, UMC Utrecht, 3584CX Utrecht, The Netherlands.; UMC Utrecht RM Center, Circulatory Health Laboratory, 3584CT Utrecht, The Netherlands.
Xiao J; Institute of Cardiovascular Sciences, Shanghai University, Shanghai 200444, China.
A Doevendans P; Department of Cardiology, Experimental Cardiology Laboratory, UMC Utrecht, 3584CX Utrecht, The Netherlands.; Utrecht University, 3584CS Utrecht, The Netherlands.; Netherlands Heart Institute (NHI), Central Military Hospital (CMH), 3511EP Utrecht, The Netherlands.
Schiffelers RM; Division LAB, CDL Research, UMC Utrecht, 3584CX Utrecht, The Netherlands.
Lei Z; Department of Cardiology, Experimental Cardiology Laboratory, UMC Utrecht, 3584CX Utrecht, The Netherlands.; Division LAB, CDL Research, UMC Utrecht, 3584CX Utrecht, The Netherlands.
Sluijter JPG; Department of Cardiology, Experimental Cardiology Laboratory, UMC Utrecht, 3584CX Utrecht, The Netherlands.; UMC Utrecht RM Center, Circulatory Health Laboratory, 3584CT Utrecht, The Netherlands.; Utrecht University, 3584CS Utrecht, The Netherlands.
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Źródło:
Biomolecules [Biomolecules] 2020 Aug 19; Vol. 10 (9). Date of Electronic Publication: 2020 Aug 19.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Myocardium*/cytology
Myocardium*/metabolism
Myocytes, Cardiac*/cytology
Myocytes, Cardiac*/metabolism
Regeneration*
Animals ; Cell Differentiation ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Plasma extracellular vesicle proteins are associated with stress-induced myocardial ischemia in women presenting with chest pain.
Autorzy:
Dekker M; Department of Vascular Surgery, University Medical Centre, Utrecht, the Netherlands. .; Department of Cardiology, Academic Medical Centre, Amsterdam, the Netherlands. .; Department of Cardiology, UMC Utrecht, Heidelberglaan 100, 3508GA, Utrecht, the Netherlands. .
Waissi F; Department of Vascular Surgery, University Medical Centre, Utrecht, the Netherlands.; Department of Cardiology, Academic Medical Centre, Amsterdam, the Netherlands.
van Bennekom J; Department of Vascular Surgery, University Medical Centre, Utrecht, the Netherlands.
Silvis MJM; Department of Cardiology, University Medical Centre, Utrecht, the Netherlands.
Timmerman N; Department of Vascular Surgery, University Medical Centre, Utrecht, the Netherlands.
Bank IEM; Department of Cardiology, St. Antonius Hospital, Nieuwegein, the Netherlands.
Walter JE; Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Mueller C; Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Schoneveld AH; Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, the Netherlands.
Schiffelers RM; Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, the Netherlands.
Pasterkamp G; Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, the Netherlands.
Grobbee DE; Julius Center for Health Sciences and Primary Care, University Medical Centre, Utrecht, the Netherlands.
de Winter RJ; Department of Cardiology, Academic Medical Centre, Amsterdam, the Netherlands.
Mosterd A; Department of Cardiology, Meander Medical Centre, Amersfoort, the Netherlands.
de Kleijn DPV; Department of Vascular Surgery, University Medical Centre, Utrecht, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands.
Timmers L; Department of Cardiology, St. Antonius Hospital, Nieuwegein, the Netherlands.
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Źródło:
Scientific reports [Sci Rep] 2020 Jul 23; Vol. 10 (1), pp. 12257. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Stress, Physiological*
Chest Pain/*etiology
Chest Pain/*metabolism
Extracellular Vesicles/*metabolism
Myocardial Ischemia/*etiology
Myocardial Ischemia/*metabolism
Proteins/*metabolism
Aged ; Biomarkers ; Computed Tomography Angiography ; Female ; Humans ; Male ; Middle Aged ; Myocardial Ischemia/diagnosis ; Positron Emission Tomography Computed Tomography ; Proteome ; Proteomics/methods ; Risk Factors ; Sex Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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