Autor: "Schildhaus HU" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Expression of cell cycle regulators and frequency of TP53 mutations in high risk gastrointestinal stromal tumors prior to adjuvant imatinib treatment.
Autorzy:: Ihle MA; Institute of Pathology, University Hospital Cologne, Cologne, Germany.
Huss S; Gerhard Domagk Institute of Pathology, University Hospital Münster, Münster, Germany.
Jeske W; Institute of Pathology, University Hospital Cologne, Cologne, Germany.
Hartmann W; Gerhard Domagk Institute of Pathology, University Hospital Münster, Münster, Germany.
Merkelbach-Bruse S; Institute of Pathology, University Hospital Cologne, Cologne, Germany.
Schildhaus HU; Institute of Pathology, University Hospital Göttingen, Göttingen, Germany.
Büttner R; Institute of Pathology, University Hospital Cologne, Cologne, Germany.
Sihto H; Laboratory of Molecular Oncology, Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland.
Sundby Hall K; Department of Oncology, the Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Eriksson M; Department of Oncology, Skåne University Hospital, Lund University, Lund, Sweden.
Reichardt P; HELIOS Klinikum Berlin-Buch, Berlin, Germany.
Joensuu H; Department of Oncology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Wardelmann E; Gerhard Domagk Institute of Pathology, University Hospital Münster, Münster, Germany.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2018 Feb 16; Vol. 13 (2), pp. e0193048. Date of Electronic Publication: 2018 Feb 16 (Print Publication: 2018).
Typ publikacji:: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:: Mutation*
Antineoplastic Agents/*therapeutic use
Cell Cycle Proteins/*genetics
Gastrointestinal Neoplasms/*drug therapy
Gastrointestinal Neoplasms/*genetics
Gastrointestinal Stromal Tumors/*drug therapy
Gastrointestinal Stromal Tumors/*genetics
Imatinib Mesylate/*therapeutic use
Tumor Suppressor Protein p53/*genetics
Adult ; Aged ; Aged, 80 and over ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Cell Cycle Proteins/metabolism ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Female ; Gastrointestinal Neoplasms/metabolism ; Gastrointestinal Stromal Tumors/metabolism ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/metabolism ; Prognosis ; Risk Factors ; Young Adult

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Skocz do pozycji: 2.

Tytuł:: Massively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy.
Autorzy:: Heydt C; Institute of Pathology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany. .
Kumm N; Institute of Pathology, University Hospital Erlangen, Krankenhausstraße 8-10, 91054, Erlangen, Germany. .
Fassunke J; Institute of Pathology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany. .
Künstlinger H; Institute of Pathology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany. .
Ihle MA; Institute of Pathology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany. .
Scheel A; Institute of Pathology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany. .
Schildhaus HU; Institute of Pathology, University Hospital Göttingen, Robert-Koch-Strasse 40, 37075, Göttingen, Germany. hans-ulrich.schildhaus@med.uni-goettingen.de.
Haller F; Institute of Pathology, University Hospital Erlangen, Krankenhausstraße 8-10, 91054, Erlangen, Germany. .
Büttner R; Institute of Pathology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany. .
Odenthal M; Institute of Pathology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany. .
Wardelmann E; Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Albert-Schweitzer-Campus 1, Gebäude D17, 48149, Münster, Germany. .
Merkelbach-Bruse S; Institute of Pathology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany. .; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2015 Apr 15; Vol. 15, pp. 291. Date of Electronic Publication: 2015 Apr 15.
Typ publikacji:: Journal Article
MeSH Terms:: Drug Resistance, Neoplasm/*genetics
Gastrointestinal Neoplasms/*genetics
Gastrointestinal Stromal Tumors/*genetics
High-Throughput Nucleotide Sequencing/*methods
Protein Kinase Inhibitors/*therapeutic use
Adult ; Aged ; Aged, 80 and over ; Cohort Studies ; Drug Resistance, Neoplasm/drug effects ; Female ; Gastrointestinal Neoplasms/diagnosis ; Gastrointestinal Neoplasms/drug therapy ; Gastrointestinal Stromal Tumors/diagnosis ; Gastrointestinal Stromal Tumors/drug therapy ; Humans ; Male ; Middle Aged ; Protein Kinase Inhibitors/pharmacology ; Retrospective Studies