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Tytuł:
Publisher Correction: Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker.
Autorzy:
Johansson P; Faculty of Medicine, Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Virchowstr. 177, 45122, Essen, Germany. .
Laguna T; Computational Biology Group, Precision Nutrition and Cancer Research Program, IMDEA Food Institute, 28049, Madrid, Spain. .
Ossowski J; Institute for Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany.; Institute of Human Genetics, Medical School Hannover (MHH), Hannover, Germany.
Pancaldi V; Centre de Recherches en Cancérologie de Toulouse (CRCT), Université de Toulouse, CNRS, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, INSERM U1037, 31037, Toulouse, France.; Barcelona Supercomputing Center, 08034, Barcelona, Spain.
Brauser M; Faculty of Medicine, Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Virchowstr. 177, 45122, Essen, Germany.
Dührsen U; Department of Hematology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Keuneke L; Institute for Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany.
Queiros A; Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), University of Barcelona, 08036, Barcelona, Spain.
Richter J; Institute for Pathology, Christian-Albrechts-University Kiel and University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany.
Martín-Subero JI; Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), University of Barcelona, 08036, Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010, Barcelona, Spain.
Siebert R; Institute for Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany.; Institute of Human Genetics, University of Ulm and University Medical Center Ulm, Ulm, Germany.
Schlegelberger B; Institute of Human Genetics, Medical School Hannover (MHH), Hannover, Germany.
Küppers R; Faculty of Medicine, Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Virchowstr. 177, 45122, Essen, Germany.
Dürig J; Department of Internal Medicine, University Hospital Essen, St. Josef-Krankenhaus, University Medicine Essen, Essen, Germany.
Penas EMM; Institute for Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany.
Pau ECS; Computational Biology Group, Precision Nutrition and Cancer Research Program, IMDEA Food Institute, 28049, Madrid, Spain.
Bergmann AK; Institute of Human Genetics, Medical School Hannover (MHH), Hannover, Germany.
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Źródło:
Clinical epigenetics [Clin Epigenetics] 2023 Jan 06; Vol. 15 (1), pp. 3. Date of Electronic Publication: 2023 Jan 06.
Typ publikacji:
Published Erratum
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker.
Autorzy:
Johansson P; Faculty of Medicine, Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Virchowstr. 177, 45122, Essen, Germany. .
Laguna T; Computational Biology Group, Precision Nutrition and Cancer Research Program, IMDEA Food Institute, 28049, Madrid, Spain. .
Ossowski J; Institute for Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany.; Institute of Human Genetics, Medical School Hannover (MHH), Hannover, Germany.
Pancaldi V; Centre de Recherches en Cancérologie de Toulouse (CRCT), Université de Toulouse, CNRS, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, INSERM U1037, 31037, Toulouse, France.; Barcelona Supercomputing Center, 08034, Barcelona, Spain.
Brauser M; Faculty of Medicine, Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Virchowstr. 177, 45122, Essen, Germany.
Dührsen U; Department of Hematology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Keuneke L; Institute for Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany.
Queiros A; Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), University of Barcelona, 08036, Barcelona, Spain.
Richter J; Institute for Pathology, Christian-Albrechts-University Kiel and University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany.
Martín-Subero JI; Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), University of Barcelona, 08036, Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010, Barcelona, Spain.
Siebert R; Institute for Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany.; Institute of Human Genetics, University of Ulm and University Medical Center Ulm, Ulm, Germany.
Schlegelberger B; Institute of Human Genetics, Medical School Hannover (MHH), Hannover, Germany.
Küppers R; Faculty of Medicine, Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Virchowstr. 177, 45122, Essen, Germany.
Dürig J; Department of Internal Medicine, University Hospital Essen, St. Josef-Krankenhaus, University Medicine Essen, Essen, Germany.
Murga Penas EM; Institute for Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany.
Carillo-de Santa Pau E; Computational Biology Group, Precision Nutrition and Cancer Research Program, IMDEA Food Institute, 28049, Madrid, Spain.
Bergmann AK; Institute of Human Genetics, Medical School Hannover (MHH), Hannover, Germany.
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Źródło:
Clinical epigenetics [Clin Epigenetics] 2022 Nov 14; Vol. 14 (1), pp. 148. Date of Electronic Publication: 2022 Nov 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Leukemia, Large Granular Lymphocytic*/genetics
Leukemia, Large Granular Lymphocytic*/metabolism
Leukemia, Large Granular Lymphocytic*/pathology
Humans ; Epigenome ; DNA Methylation ; Transcription Factors/genetics ; Biomarkers/metabolism ; Tumor Suppressor Proteins/genetics ; Repressor Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Beyond Pathogenic RUNX1 Germline Variants: The Spectrum of Somatic Alterations in RUNX1-Familial Platelet Disorder with Predisposition to Hematologic Malignancies.
Autorzy:
Förster A; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Decker M; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Schlegelberger B; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Ripperger T; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
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Źródło:
Cancers [Cancers (Basel)] 2022 Jul 14; Vol. 14 (14). Date of Electronic Publication: 2022 Jul 14.
Typ publikacji:
Journal Article; Review
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
OnkoRiskNET: a multicenter, interdisciplinary, telemedicine-based model to improve care for patients with a genetic tumor risk syndrome.
Autorzy:
Tecklenburg J; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Vajen B; Department of Human Genetics, Hannover Medical School, Hannover, Germany. .
Morlot S; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Anders P; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Memenga P; Department of Journalism and Communication Research, Drama and Media, Hanover University of Music, Hannover, Germany.
Link E; Department of Journalism and Communication Research, Drama and Media, Hanover University of Music, Hannover, Germany.
Baumann E; Department of Journalism and Communication Research, Drama and Media, Hanover University of Music, Hannover, Germany.
Wölffling S; Department of Human Genetics, University Hospital Carl Gustav Carus Dresden, Dresden, Germany.
Schröck E; Department of Human Genetics, University Hospital Carl Gustav Carus Dresden, Dresden, Germany.
Bergmann AK; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Schlegelberger B; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
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Źródło:
BMC health services research [BMC Health Serv Res] 2022 Jun 21; Vol. 22 (1), pp. 805. Date of Electronic Publication: 2022 Jun 21.
Typ publikacji:
Journal Article; Multicenter Study
MeSH Terms:
Neoplasms*/diagnosis
Neoplasms*/genetics
Neoplasms*/therapy
Telemedicine*
Genetic Counseling ; Humans ; Medical Oncology ; Syndrome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MiR-129-5p exerts Wnt signaling-dependent tumor-suppressive functions in hepatocellular carcinoma by directly targeting hepatoma-derived growth factor HDGF.
Autorzy:
Huge N; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
Reinkens T; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
Buurman R; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
Sandbothe M; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
Bergmann A; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
Wallaschek H; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
Vajen B; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
Stalke A; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
Decker M; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
Eilers M; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
Schäffer V; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
Dittrich-Breiholz O; Research Core Unit Genomics, Hannover Medical School, Hannover, Germany.
Gürlevik E; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Kühnel F; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Schlegelberger B; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
Illig T; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.; Hannover Unified Biobank (HUB), Hannover Medical School, Hannover, Germany.
Skawran B; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany. .
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Źródło:
Cancer cell international [Cancer Cell Int] 2022 May 16; Vol. 22 (1), pp. 192. Date of Electronic Publication: 2022 May 16.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MicroRNA-449a Inhibits Triple Negative Breast Cancer by Disturbing DNA Repair and Chromatid Separation.
Autorzy:
Vajen B; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30629 Hannover, Germany.
Bhowmick R; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
Greiwe L; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30629 Hannover, Germany.
Schäffer V; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30629 Hannover, Germany.
Eilers M; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30629 Hannover, Germany.
Reinkens T; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30629 Hannover, Germany.
Stalke A; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30629 Hannover, Germany.
Schmidt G; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30629 Hannover, Germany.
Fiedler J; Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Carl-Neuberg-Str. 1, 30629 Hannover, Germany.; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Nikolai-Fuchs Str. 1, 30625 Hannover, Germany.
Thum T; Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Carl-Neuberg-Str. 1, 30629 Hannover, Germany.; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Nikolai-Fuchs Str. 1, 30625 Hannover, Germany.; REBIRTH Center for Translational Regenerative Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30629 Hannover, Germany.
DeLuca DS; German Center for Lung Research (BREATH), Hannover Medical School, Carl-Neuberg-Str. 1, 30629 Hannover, Germany.
Hickson ID; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
Schlegelberger B; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30629 Hannover, Germany.
Illig T; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30629 Hannover, Germany.
Skawran B; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str. 1, 30629 Hannover, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 May 04; Vol. 23 (9). Date of Electronic Publication: 2022 May 04.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
MicroRNAs*/metabolism
Triple Negative Breast Neoplasms*/pathology
Cell Line, Tumor ; Chromatids/metabolism ; DNA Repair/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Transcriptional and Mutational Profiling of B-Other Acute Lymphoblastic Leukemia for Improved Diagnostics.
Autorzy:
Chouvarine P; Institute of Human Genetics, Hannover Medical School (MHH), 30625 Hannover, Germany.
Antić Ž; Institute of Human Genetics, Hannover Medical School (MHH), 30625 Hannover, Germany.
Lentes J; Institute of Human Genetics, Hannover Medical School (MHH), 30625 Hannover, Germany.
Schröder C; Institute of Human Genetics, Hannover Medical School (MHH), 30625 Hannover, Germany.
Alten J; Berlin-Frankfurt-Münster ALL Study Group Germany (BFM-G), Department of Pediatrics, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Brüggemann M; Department of Hematology, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Carrillo-de Santa Pau E; Computational Biology Group, Precision Nutrition and Cancer Research Program, IMDEA Food Institute, 28049 Madrid, Spain.
Illig T; Institute of Human Genetics, Hannover Medical School (MHH), 30625 Hannover, Germany.
Laguna T; Computational Biology Group, Precision Nutrition and Cancer Research Program, IMDEA Food Institute, 28049 Madrid, Spain.
Schewe D; Berlin-Frankfurt-Münster ALL Study Group Germany (BFM-G), Department of Pediatrics, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Stanulla M; Pediatric Hematology and Oncology, Hannover Medical School (MHH), 30625 Hannover, Germany.
Tang M; Institute of Human Genetics, Hannover Medical School (MHH), 30625 Hannover, Germany.
Zimmermann M; Pediatric Hematology and Oncology, Hannover Medical School (MHH), 30625 Hannover, Germany.
Schrappe M; Department of Hematology, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Schlegelberger B; Institute of Human Genetics, Hannover Medical School (MHH), 30625 Hannover, Germany.
Cario G; Department of Hematology, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Bergmann AK; Institute of Human Genetics, Hannover Medical School (MHH), 30625 Hannover, Germany.
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Źródło:
Cancers [Cancers (Basel)] 2021 Nov 12; Vol. 13 (22). Date of Electronic Publication: 2021 Nov 12.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Clinical Utility of Optical Genome Mapping for the Assessment of Genomic Aberrations in Acute Lymphoblastic Leukemia.
Autorzy:
Lühmann JL; Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.
Stelter M; Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.
Wolter M; Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.
Kater J; Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.
Lentes J; Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.
Bergmann AK; Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.
Schieck M; Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.
Göhring G; Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.
Möricke A; Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.
Cario G; Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.
Žaliová M; Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, CZ-15006 Prague, Czech Republic.
Schrappe M; Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.
Schlegelberger B; Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.
Stanulla M; Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany.
Steinemann D; Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.
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Źródło:
Cancers [Cancers (Basel)] 2021 Aug 30; Vol. 13 (17). Date of Electronic Publication: 2021 Aug 30.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Establishment and Characterization of a Sclerosing Spindle Cell Rhabdomyosarcoma Cell Line with a Complex Genomic Profile.
Autorzy:
Schleicher S; Department of Hematology and Oncology, Eberhard Karls University Tuebingen, Children's Hospital, 72076 Tuebingen, Germany.
Grote S; Department of Hematology and Oncology, Eberhard Karls University Tuebingen, Children's Hospital, 72076 Tuebingen, Germany.
Malenke E; Department of Hematology and Oncology, Eberhard Karls University Tuebingen, Children's Hospital, 72076 Tuebingen, Germany.
Chan KC; Department of Hematology and Oncology, Eberhard Karls University Tuebingen, Children's Hospital, 72076 Tuebingen, Germany.
Schaller M; Department of Dermatology, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany.
Fehrenbacher B; Department of Dermatology, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany.
Riester R; Department of Orthopaedic Surgery, Eberhard Karls University Tuebingen, 72072 Tuebingen, Germany.
Kluba T; Department for Orthopaedic Surgery, Hospital Dresden-Friedrichstadt, 01067 Dresden, Germany.
Frauenfeld L; Institute of Pathology and Neuropathology, University Hospital Tuebingen, 72076 Tuebingen, Germany.
Boesmueller H; Institute of Pathology and Neuropathology, University Hospital Tuebingen, 72076 Tuebingen, Germany.
Göhring G; Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.
Schlegelberger B; Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.
Handgretinger R; Department of Hematology and Oncology, Eberhard Karls University Tuebingen, Children's Hospital, 72076 Tuebingen, Germany.
Kopp HG; Robert Bosch Cancer Center/RBCT Stuttgart, 70376 Stuttgart, Germany.
Traub F; Department of Orthopedics and Traumatology, University Medical Centre Mainz, Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Boehme KA; Department of Orthopaedic Surgery, Eberhard Karls University Tuebingen, 72072 Tuebingen, Germany.; G.E.R.N. Center for Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Engesserstr. 4, 79108 Freiburg, Germany.
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Źródło:
Cells [Cells] 2020 Dec 11; Vol. 9 (12). Date of Electronic Publication: 2020 Dec 11.
Typ publikacji:
Journal Article
MeSH Terms:
Genomics*
Rhabdomyosarcoma/*pathology
Adipogenesis ; Animals ; Biomarkers/metabolism ; Cell Differentiation ; Cell Line Authentication/methods ; Comparative Genomic Hybridization ; Female ; Humans ; Karyotyping ; Mice ; Mice, Inbred NOD ; Mice, SCID ; MyoD Protein/genetics ; Rhabdomyosarcoma/drug therapy ; Rhabdomyosarcoma/genetics ; Signal Transduction ; Tumor Cells, Cultured ; Tumor Suppressor Protein p53/genetics ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
From a variant of unknown significance to pathogenic: Reclassification of a large novel duplication in BRCA2 by high-throughput sequencing.
Autorzy:
van Luttikhuizen JL; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Bublitz J; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Schubert S; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Schmidt G; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Hofmann W; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Morlot S; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Buurman R; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Auber B; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Schlegelberger B; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Steinemann D; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
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Źródło:
Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2020 Sep; Vol. 8 (9), pp. e1045. Date of Electronic Publication: 2019 Nov 13.
Typ publikacji:
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Duplication*
BRCA2 Protein/*genetics
Hereditary Breast and Ovarian Cancer Syndrome/*genetics
Adult ; Chromosome Breakpoints ; Female ; Genetic Testing ; Hereditary Breast and Ovarian Cancer Syndrome/pathology ; High-Throughput Nucleotide Sequencing ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MTF1 binds to metal-responsive element e within the ATP7B promoter and is a strong candidate in regulating the ATP7B expression.
Autorzy:
Stalke A; Department of Human Genetics, Hannover Medical School, Hannover, Germany.; Department of Pediatric Gastroenterology and Hepatology, Division of Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
Pfister ED; Department of Pediatric Gastroenterology and Hepatology, Division of Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
Baumann U; Department of Pediatric Gastroenterology and Hepatology, Division of Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
Illig T; Department of Human Genetics, Hannover Medical School, Hannover, Germany.; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.
Reischl E; Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany.
Sandbothe M; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Vajen B; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Huge N; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Schlegelberger B; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
von Neuhoff N; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Skawran B; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
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Źródło:
Annals of human genetics [Ann Hum Genet] 2020 Mar; Vol. 84 (2), pp. 195-200. Date of Electronic Publication: 2019 Oct 09.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Promoter Regions, Genetic*
Response Elements*
Carcinoma, Hepatocellular/*metabolism
Copper-Transporting ATPases/*genetics
DNA-Binding Proteins/*metabolism
Liver Neoplasms/*metabolism
Transcription Factors/*metabolism
Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Copper-Transporting ATPases/metabolism ; DNA-Binding Proteins/genetics ; Hep G2 Cells ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Metals/metabolism ; Transcription Factors/genetics ; Transcription Factor MTF-1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dihydropyrimidine Dehydrogenase Testing prior to Treatment with 5-Fluorouracil, Capecitabine, and Tegafur: A Consensus Paper.
Autorzy:
Wörmann B; Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie, Berlin, Germany, .; Medizinische Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie, Berlin, Germany, .
Bokemeyer C; II. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Burmeister T; Medizinische Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie, Berlin, Germany.
Köhne CH; Klinik für Onkologie und Hämatologie, Oldenburg, Germany.
Schwab M; Dr. Margarete Fischer-Bosch-Institut für Klinische Pharmakologie, Stuttgart, Germany.; Departments of Clinical Pharmacology, and of Biochemistry and Pharmacy, University of Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.
Arnold D; Asklepios Tumorzentrum Hamburg, AK Altona, Hamburg, Germany.
Blohmer JU; Klinik für Gynäkologie, Charité, Berlin, Germany.
Borner M; Onkologisches Zentrum, Oncocare, Engeriedspital, Bern, Switzerland.
Brucker S; Department für Frauengesundheit, Universitätsklinikum Tübingen, Tübingen, Germany.
Cascorbi I; Institut für Experimentelle und Klinische Pharmakologie, Universitätsklinikum Kiel, Kiel, Germany.
Decker T; Onkologische Praxis, Ravensburg, Germany.
de Wit M; Klinik für Innere Medizin, Hämatologie, Onkologie und Palliativmedizin, Vivantes Klinikum Neukölln, Berlin, Germany.
Dietz A; Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Universitätsklinikum Leipzig, Leipzig, Germany.
Einsele H; Medizinische Klinik II, Universitätsklinikum Würzburg, Würzburg, Germany.
Eisterer W; Abteilung für Innere Medizin und Onkologie, Klinikum Klagenfurt, Klagenfurt am Wörthersee, Austria.
Folprecht G; Medizinische Klinik I, Universitätsklinikum Dresden, Dresden, Germany.
Hilbe W; Medizinische Abteilung am Wilhelminenspital, Wien, Austria.
Hoffmann J; Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Universitätsklinikum Heidelberg, Heidelberg, Germany.
Knauf W; Centrum für Hämatologie und Onkologie, Bethanien-Krankenhaus, Frankfurt/Main, Germany.
Kunzmann V; Medizinische Klinik II, Universitätsklinikum Würzburg, Würzburg, Germany.
Largiadèr CR; Universitätsinstitut für Klinische Chemie, Inselspital Bern, Bern, Switzerland.
Lorenzen S; Klinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar, München, Germany.
Lüftner D; Medizinische Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie, Berlin, Germany.
Moehler M; I. Medizinische Klinik, Universitätsmedizin Mainz, Mainz, Germany.
Nöthen MM; Institut für Humangenetik, Universitätsklinikum Bonn, Bonn, Germany.
Pox C; Medizinische Klinik, Krankenhaus St. Joseph-Stift, Bremen, Germany.
Reinacher-Schick A; Hämatologie, Onkologie und Palliativmedizin, Katholisches Klinikum, Ruhr-Universität, Bochum, Germany.
Scharl A; Frauenkliniken Amberg-Tirschenreuth-Weiden, Amberg, Germany.
Schlegelberger B; Institut für Humangenetik, Medizinische Hochschule Hannover, Hannover, Germany.
Seufferlein T; Klinik für Innere Medizin I, Universitätsklinikum Ulm, Ulm, Germany.
Sinn M; II. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
Stroth M; Klinik für Frauenheilkunde, Berlin, Germany.
Tamm I; Onkologische Schwerpunktpraxis Kurfürstendamm, Berlin, Germany.
Trümper L; Klinik für Hämatologie und Medizinische Onkologie, Universitätsmedizin Göttingen, Göttingen, Germany.
Wilhelm M; Klinik für Innere Medizin 5, Klinikum Nürnberg, Paracelsus Medical University, Nuremberg, Germany.
Wöll E; Klinik für Innere Medizin, Klinikum St. Vinzenz, Zams, Austria.
Hofheinz RD; Interdisziplinäres Tumorzentrum, Universitätsmedizin Mannheim, Mannheim, Germany.
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Źródło:
Oncology research and treatment [Oncol Res Treat] 2020; Vol. 43 (11), pp. 628-636. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Antimetabolites, Antineoplastic/*administration & dosage
Dihydrouracil Dehydrogenase (NADP)/*genetics
Fluorouracil/*administration & dosage
Genetic Testing/*methods
Neoplasms/*drug therapy
Antimetabolites, Antineoplastic/adverse effects ; Austria ; Capecitabine/administration & dosage ; Capecitabine/adverse effects ; Consensus ; Female ; Fluorouracil/adverse effects ; Genetic Testing/standards ; Genotype ; Germany ; Humans ; Male ; Mutation ; Neoplasms/genetics ; Phenotype ; Practice Guidelines as Topic ; Switzerland ; Tegafur/administration & dosage ; Tegafur/adverse effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Routes of Clonal Evolution into Complex Karyotypes in Myelodysplastic Syndrome Patients with 5q Deletion.
Autorzy:
Feurstein S; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover, Germany. .; Department of Medicine, Section of Hematology/Oncology, The University of Chicago, 900 E 57th street, Chicago, IL 60637, USA. .
Thomay K; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover, Germany. .
Hofmann W; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover, Germany. .
Buesche G; Institute of Pathology, Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover, Germany. .
Kreipe H; Institute of Pathology, Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover, Germany. .
Thol F; Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover, Germany. .
Heuser M; Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover, Germany. .
Ganser A; Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover, Germany. .
Schlegelberger B; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover, Germany. Schlegelberger..
Göhring G; Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover, Germany. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2018 Oct 21; Vol. 19 (10). Date of Electronic Publication: 2018 Oct 21.
Typ publikacji:
Journal Article
MeSH Terms:
Clonal Evolution*
Karyotype*
Anemia, Macrocytic/*genetics
Cells, Cultured ; Chromosome Deletion ; Chromosomes, Human, Pair 5/genetics ; Humans
SCR Disease Name:
Chromosome 5q Deletion Syndrome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Octasomy 21 in a patient with secondary AML after CMML: the role of acquired NRAS mutations in triggering aneuploidy.
Autorzy:
Thomay K; a Department of Human Genetics , Hannover Medical School , Hannover , Germany.
Behrens YL; a Department of Human Genetics , Hannover Medical School , Hannover , Germany.
Lentes J; a Department of Human Genetics , Hannover Medical School , Hannover , Germany.
Wittner N; a Department of Human Genetics , Hannover Medical School , Hannover , Germany.
Wittig V; a Department of Human Genetics , Hannover Medical School , Hannover , Germany.
Rothe D; a Department of Human Genetics , Hannover Medical School , Hannover , Germany.
Steinemann D; a Department of Human Genetics , Hannover Medical School , Hannover , Germany.
Schlegelberger B; a Department of Human Genetics , Hannover Medical School , Hannover , Germany.
Göhring G; a Department of Human Genetics , Hannover Medical School , Hannover , Germany.
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Źródło:
Leukemia & lymphoma [Leuk Lymphoma] 2018 Oct; Vol. 59 (10), pp. 2478-2481. Date of Electronic Publication: 2018 Jan 31.
Typ publikacji:
Case Reports; Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
Aneuploidy*
Chromosomes, Human, Pair 21/*genetics
GTP Phosphohydrolases/*genetics
Leukemia, Myeloid, Acute/*genetics
Membrane Proteins/*genetics
Neoplasms, Second Primary/*genetics
Aged ; Antimetabolites, Antineoplastic/therapeutic use ; Azacitidine/therapeutic use ; Erythropoietin/therapeutic use ; Fatal Outcome ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Humans ; Karyotyping ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myelomonocytic, Chronic/drug therapy ; Leukemia, Myelomonocytic, Chronic/genetics ; Male
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prevalence of pathogenic BRCA1/2 germline mutations among 802 women with unilateral triple-negative breast cancer without family cancer history.
Autorzy:
Engel C; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Rhiem K; Center for Hereditary Breast and Ovarian Cancer and Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Kerpener Strasse 34, 50931, Cologne, Germany.
Hahnen E; Center for Hereditary Breast and Ovarian Cancer and Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Kerpener Strasse 34, 50931, Cologne, Germany.
Loibl S; German Breast Group, Neu-Isenburg, Germany.; Centre for Haematology and Oncology Bethanien, Frankfurt, Germany.
Weber KE; German Breast Group, Neu-Isenburg, Germany.
Seiler S; German Breast Group, Neu-Isenburg, Germany.
Zachariae S; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Hauke J; Center for Hereditary Breast and Ovarian Cancer and Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Kerpener Strasse 34, 50931, Cologne, Germany.
Wappenschmidt B; Center for Hereditary Breast and Ovarian Cancer and Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Kerpener Strasse 34, 50931, Cologne, Germany.
Waha A; Center for Hereditary Breast and Ovarian Cancer and Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Kerpener Strasse 34, 50931, Cologne, Germany.
Blümcke B; Center for Hereditary Breast and Ovarian Cancer and Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Kerpener Strasse 34, 50931, Cologne, Germany.
Kiechle M; Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, Klinikum rechts der Isar, Technical University Munich (TUM), Munich, Germany.
Meindl A; Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, Klinikum rechts der Isar, Technical University Munich (TUM), Munich, Germany.
Niederacher D; Department of Gynecology and Obstetrics, University Hospital of the Heinrich-Heine University, Düsseldorf, Germany.
Bartram CR; Institute of Human Genetics, University Hospital, University of Heidelberg, Heidelberg, Germany.
Speiser D; Zentrum für Familiären Brust- und Eierstockkrebs, Klinik für Gynäkologie mit Brustzentrum, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Schlegelberger B; Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Arnold N; Institute of Clinical Molecular Biology/Department of Gynecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany.
Wieacker P; Institute of Human Genetics, University Hospital Münster, Münster, Germany.
Leinert E; Department of Gynecology and Obstetrics, University Hospital Ulm, Ulm, Germany.
Gehrig A; Institute of Human Genetics, University Würzburg, Würzburg, Germany.
Briest S; Center for Hereditary Breast and Ovarian Cancer, University Hospital Leipzig, Leipzig, Germany.
Kast K; Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Riess O; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.
Emons G; Klinik für Gynäkologie und Geburtshilfe, Universitätsmedizin, Göttingen, Germany.
Weber BHF; Institute of Human Genetics, University of Regensburg, Regensburg, Germany.
Engel J; Munich Cancer Registry (MCR) of the Munich Tumour Centre (TZM), Institute for Medical Information Processing, Biometry and Epidemiology (IBE), University Hospital of Munich, Ludwig-Maximilians-University (LMU), Munich, Germany.
Schmutzler RK; Center for Hereditary Breast and Ovarian Cancer and Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Kerpener Strasse 34, 50931, Cologne, Germany. .
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Corporate Authors:
German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC)
Źródło:
BMC cancer [BMC Cancer] 2018 Mar 07; Vol. 18 (1), pp. 265. Date of Electronic Publication: 2018 Mar 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Testing*
Germ-Line Mutation*
BRCA1 Protein/*genetics
BRCA2 Protein/*genetics
Biomarkers, Tumor/*genetics
Triple Negative Breast Neoplasms/*genetics
Unilateral Breast Neoplasms/*genetics
Adult ; Aged ; Female ; Follow-Up Studies ; Germany/epidemiology ; Humans ; Middle Aged ; Prevalence ; Prognosis ; Triple Negative Breast Neoplasms/epidemiology ; Triple Negative Breast Neoplasms/pathology ; Unilateral Breast Neoplasms/epidemiology ; Unilateral Breast Neoplasms/pathology ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A common ancestral DNMT3A-mutated preleukemic clone giving rise to AML and MDS in an adolescent girl.
Autorzy:
Göhring G; a Institute of Human Genetics , Hannover Medical School , Hannover , Germany.
Thomay K; a Institute of Human Genetics , Hannover Medical School , Hannover , Germany.
Schmidt G; a Institute of Human Genetics , Hannover Medical School , Hannover , Germany.
Ripperger T; a Institute of Human Genetics , Hannover Medical School , Hannover , Germany.
Xu M; a Institute of Human Genetics , Hannover Medical School , Hannover , Germany.; b Manitoba Institute of Cell Biology , CancerCare Manitoba , Winnipeg , Canada.
Wittner N; a Institute of Human Genetics , Hannover Medical School , Hannover , Germany.
Chao MM; c Department of Pediatric Hematology and Oncology , Hannover Medical School , Hannover , Germany.
Baumann I; d Department of Pathology , Clinical Center , Böblingen , Germany.
Niewisch M; e Division of Pediatric Hematology and Oncology, Department of Pediatrics , University Medical Center Freiburg , Freiburg , Germany.
Reinhardt D; f Clinic for Pediatrics III , University Hospital Essen , Essen , Germany.
Klingebiel T; g Hospital for Children and Adolescents , University Hospital Frankfurt , Frankfurt , Germany.
Thol F; h Department of Hematology, Hemostasis, Oncology and SCT , Hannover Medical School , Hannover , Germany.
Schlegelberger B; a Institute of Human Genetics , Hannover Medical School , Hannover , Germany.
Niemeyer CM; e Division of Pediatric Hematology and Oncology, Department of Pediatrics , University Medical Center Freiburg , Freiburg , Germany.
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Źródło:
Leukemia & lymphoma [Leuk Lymphoma] 2017 Mar; Vol. 58 (3), pp. 718-721. Date of Electronic Publication: 2016 Nov 28.
Typ publikacji:
Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutation*
Clonal Evolution/*genetics
DNA (Cytosine-5-)-Methyltransferases/*genetics
Leukemia, Myeloid, Acute/*genetics
Myelodysplastic Syndromes/*genetics
Precancerous Conditions/*genetics
Adolescent ; Alleles ; Biomarkers ; Bone Marrow/pathology ; DNA Methylation ; DNA Methyltransferase 3A ; DNA Mutational Analysis ; Female ; Humans ; Leukemia, Myeloid, Acute/diagnosis ; Leukocyte Count ; Myelodysplastic Syndromes/diagnosis
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Frequency and prognostic impact of casein kinase 1A1 mutations in MDS patients with deletion of chromosome 5q.
Autorzy:
Heuser M; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Meggendorfer M; MLL Munich Leukemia Laboratory, Munich, Germany.
Cruz MM; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Fabisch J; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Klesse S; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Köhler L; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Göhring G; Institute of Human Genetics, Hannover Medical School, Hannover, Germany.
Ganster C; Department of Hematology and Oncology, Georg-August-Universität Göttingen, Göttingen, Germany.
Shirneshan K; Department of Hematology and Oncology, Georg-August-Universität Göttingen, Göttingen, Germany.
Gutermuth A; Department of Hematology and Oncology, Georg-August-Universität Göttingen, Göttingen, Germany.
Cerny-Reiterer S; Department of Hematology and Hemostasis, Medical University Vienna, Vienna, Austria.
Krönke J; Department of Internal Medicine III, University of Ulm, Ulm, Germany.
Panagiota V; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Haferlach C; MLL Munich Leukemia Laboratory, Munich, Germany.
Koenecke C; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Platzbecker U; Medical Department I, University Hospital Carl Gustav Carus, Dresden, Germany.
Thiede C; Medical Department I, University Hospital Carl Gustav Carus, Dresden, Germany.
Schroeder T; Department of Hematology, Oncology and Clinical Immunology, University of Duesseldorf, Medical Faculty, Duesseldorf, Germany.
Kobbe G; Department of Hematology, Oncology and Clinical Immunology, University of Duesseldorf, Medical Faculty, Duesseldorf, Germany.
Ehrlich S; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Stamer K; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Döhner K; Department of Internal Medicine III, University of Ulm, Ulm, Germany.
Valent P; Department of Hematology and Hemostasis, Medical University Vienna, Vienna, Austria.
Schlegelberger B; Institute of Human Genetics, Hannover Medical School, Hannover, Germany.
Kroeger N; Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Ganser A; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Haase D; Department of Hematology and Oncology, Georg-August-Universität Göttingen, Göttingen, Germany.
Haferlach T; MLL Munich Leukemia Laboratory, Munich, Germany.
Thol F; MLL Munich Leukemia Laboratory, Munich, Germany.
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Źródło:
Leukemia [Leukemia] 2015 Sep; Vol. 29 (9), pp. 1942-5. Date of Electronic Publication: 2015 Feb 24.
Typ publikacji:
Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
Chromosome Deletion*
Chromosomes, Human, Pair 5*
Mutation*
Casein Kinase Ialpha/*genetics
Myelodysplastic Syndromes/*genetics
Myelodysplastic Syndromes/*mortality
Humans ; Prognosis
Raport
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia.
Autorzy:
Schwarzer A; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Holtmann H; Institute of Biochemistry, Hannover Medical School, Hannover, Germany.
Brugman M; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Meyer J; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Schauerte C; Institute of Biochemistry, Hannover Medical School, Hannover, Germany.
Zuber J; Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, Vienna, Austria.
Steinemann D; Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.
Schlegelberger B; Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.
Li Z; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Baum C; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
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Źródło:
Oncogene [Oncogene] 2015 Jul; Vol. 34 (27), pp. 3593-604. Date of Electronic Publication: 2014 Sep 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Biosynthesis*/genetics
Eukaryotic Initiation Factor-4E/*physiology
Leukemia, T-Cell/*genetics
Leukemia, T-Cell/*metabolism
Multiprotein Complexes/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Animals ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Gene Expression Regulation, Leukemic ; Humans ; Mechanistic Target of Rapamycin Complex 1 ; Mechanistic Target of Rapamycin Complex 2 ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Signal Transduction ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy.
Autorzy:
Haaß W; III. Medizinische Universitätsklinik (Hämatologie und Onkologie), Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany.
Kleiner H; III. Medizinische Universitätsklinik (Hämatologie und Onkologie), Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany.
Weiß C; Abteilung Medizinische Statistik und Biomathematik, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany.
Haferlach C; MLL Münchner Leukämielabor, München, Germany.
Schlegelberger B; Institut für Zell- und Molekularpathologie, Medizinische Hochschule, Hannover, Germany.
Müller MC; III. Medizinische Universitätsklinik (Hämatologie und Onkologie), Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany.
Hehlmann R; III. Medizinische Universitätsklinik (Hämatologie und Onkologie), Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany.
Hofmann WK; III. Medizinische Universitätsklinik (Hämatologie und Onkologie), Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany.
Fabarius A; III. Medizinische Universitätsklinik (Hämatologie und Onkologie), Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany.
Seifarth W; III. Medizinische Universitätsklinik (Hämatologie und Onkologie), Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany.
Pokaż więcej
Corporate Authors:
Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung
German CML Study Group
Źródło:
PloS one [PLoS One] 2015 Jun 18; Vol. 10 (6), pp. e0129648. Date of Electronic Publication: 2015 Jun 18 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*therapeutic use
Blast Crisis/*genetics
Fusion Proteins, bcr-abl/*genetics
Imatinib Mesylate/*therapeutic use
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*pathology
Separase/*metabolism
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Blast Crisis/enzymology ; Blast Crisis/pathology ; Cell Line, Tumor ; Chromosome Aberrations ; Chromosome Breakage ; Clonal Evolution ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/enzymology ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Middle Aged ; Proteolysis ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Comprehensive MALDI-TOF biotyping of the non-redundant Harvard Pseudomonas aeruginosa PA14 transposon insertion mutant library.
Autorzy:
Oumeraci T; Institute of Cell and Molecular Pathology, Hannover Medical School (MHH), Hannover, Germany.
Jensen V; Department of Molecular Bacteriology, Helmholtz Center for Infection Research, Braunschweig, Germany; Institute of Molecular Bacteriology, Twincore, Center for Experimental and Clinical Infection Research, A joint venture of the Helmholtz Center for Infection Research Braunschweig and the MHH, Hannover, Germany.
Talbot SR; Institute of Molecular and Cell Physiology, MHH, Hannover, Germany.
Hofmann W; Institute of Cell and Molecular Pathology, Hannover Medical School (MHH), Hannover, Germany.
Kostrzewa M; Bruker Daltonik GmbH, Bremen, Germany.
Schlegelberger B; Institute of Cell and Molecular Pathology, Hannover Medical School (MHH), Hannover, Germany.
von Neuhoff N; Institute of Cell and Molecular Pathology, Hannover Medical School (MHH), Hannover, Germany.
Häussler S; Department of Molecular Bacteriology, Helmholtz Center for Infection Research, Braunschweig, Germany; Institute of Molecular Bacteriology, Twincore, Center for Experimental and Clinical Infection Research, A joint venture of the Helmholtz Center for Infection Research Braunschweig and the MHH, Hannover, Germany.
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Źródło:
PloS one [PLoS One] 2015 Feb 09; Vol. 10 (2), pp. e0117144. Date of Electronic Publication: 2015 Feb 09 (Print Publication: 2015).
Typ publikacji:
Journal Article
MeSH Terms:
Mutagenesis, Insertional/*genetics
Pseudomonas aeruginosa/*genetics
Gene Library ; Mycological Typing Techniques/methods ; Software ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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