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Tytuł :
Phenotyping of adipose, liver, and skeletal muscle insulin resistance and response to pioglitazone in spontaneously obese rhesus monkeys.
Autorzy :
Jin Shang
Previs, Stephen F.
Conarello, Stacey
Chng, Keefe
Yonghua Zhu
Souza, Sandra C.
Staup, Michael
Ying Chen
Dan Xie
Zycband, Emanuel
Schlessinger, Karni
Johnson, Victoria Plamadeala
Arreaza, Gladys
Liu, Franklin
Levitan, Diane
Liangsu Wang
van Heek, Margaret
Erion, Mark
Yixin Wang
Kelley, David E.
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Temat :
INSULIN resistance
TYPE 2 diabetes
PIOGLITAZONE
Źródło :
American Journal of Physiology: Endocrinology & Metabolism; Apr2017, Vol. 312 Issue 4, pE235-E243, 9p
Czasopismo naukowe
Tytuł :
Phenotyping of adipose, liver, and skeletal muscle insulin resistance and response to pioglitazone in spontaneously obese rhesus monkeys.
Autorzy :
Shang J; Merck & Company, Incorporated, Kenilworth, New Jersey; and .
Previs SF; Merck & Company, Incorporated, Kenilworth, New Jersey; and.
Conarello S; Merck & Company, Incorporated, Kenilworth, New Jersey; and.
Chng K; Crown Bioscience, Incorporated, Kannapolis, North Carolina.
Zhu Y; Merck & Company, Incorporated, Kenilworth, New Jersey; and.
Souza SC; Merck & Company, Incorporated, Kenilworth, New Jersey; and.
Staup M; Crown Bioscience, Incorporated, Kannapolis, North Carolina.
Chen Y; Merck & Company, Incorporated, Kenilworth, New Jersey; and.
Xie D; Merck & Company, Incorporated, Kenilworth, New Jersey; and.
Zycband E; Merck & Company, Incorporated, Kenilworth, New Jersey; and.
Schlessinger K; Merck & Company, Incorporated, Kenilworth, New Jersey; and.
Johnson VP; Merck & Company, Incorporated, Kenilworth, New Jersey; and.
Arreaza G; Merck & Company, Incorporated, Kenilworth, New Jersey; and.
Liu F; Merck & Company, Incorporated, Kenilworth, New Jersey; and.
Levitan D; Merck & Company, Incorporated, Kenilworth, New Jersey; and.
Wang L; Merck & Company, Incorporated, Kenilworth, New Jersey; and.
van Heek M; Merck & Company, Incorporated, Kenilworth, New Jersey; and.
Erion M; Merck & Company, Incorporated, Kenilworth, New Jersey; and.
Wang Y; Crown Bioscience, Incorporated, Kannapolis, North Carolina.
Kelley DE; Merck & Company, Incorporated, Kenilworth, New Jersey; and.
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Źródło :
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2017 Apr 01; Vol. 312 (4), pp. E235-E243. Date of Electronic Publication: 2017 Jan 31.
Typ publikacji :
Journal Article
MeSH Terms :
Adipose Tissue/*metabolism
Hypoglycemic Agents/*pharmacology
Insulin Resistance/*physiology
Liver/*metabolism
Muscle, Skeletal/*metabolism
Obesity/*metabolism
Thiazolidinediones/*pharmacology
Adipose Tissue/drug effects ; Animals ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Glucose Clamp Technique ; Hypoglycemic Agents/therapeutic use ; Lipolysis/physiology ; Liver/drug effects ; Macaca mulatta ; Muscle, Skeletal/drug effects ; Obesity/drug therapy ; Pioglitazone ; Thiazolidinediones/therapeutic use
Czasopismo naukowe
Tytuł :
Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3.
Autorzy :
Schlessinger K; Department of Pathology and New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA.
Levy DE
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Źródło :
Cancer research [Cancer Res] 2005 Jul 01; Vol. 65 (13), pp. 5828-34.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Cell Transformation, Neoplastic/*genetics
DNA-Binding Proteins/*genetics
Trans-Activators/*genetics
Animals ; Cell Adhesion/genetics ; Cell Growth Processes/physiology ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Cells, Cultured ; DNA-Binding Proteins/deficiency ; Enzyme Activation ; Fibroblasts/physiology ; Focal Adhesion Kinase 1 ; Focal Adhesion Protein-Tyrosine Kinases ; Gene Expression Regulation ; Genes, fos ; Genes, src ; Mice ; Mice, Inbred BALB C ; Oncogene Protein pp60(v-src)/biosynthesis ; Oncogene Protein pp60(v-src)/genetics ; Protein-Tyrosine Kinases/metabolism ; Proto-Oncogene Proteins c-fos/biosynthesis ; Proto-Oncogene Proteins c-fos/genetics ; STAT3 Transcription Factor ; Trans-Activators/deficiency
Czasopismo naukowe
Tytuł :
Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation.
Autorzy :
Yang J; Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Chatterjee-Kishore M
Staugaitis SM
Nguyen H
Schlessinger K
Levy DE
Stark GR
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Źródło :
Cancer research [Cancer Res] 2005 Feb 01; Vol. 65 (3), pp. 939-47.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
DNA-Binding Proteins/*physiology
Gene Expression Regulation/*physiology
Neoplasms/*genetics
Trans-Activators/*physiology
Animals ; DNA-Binding Proteins/biosynthesis ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Interleukin-6/pharmacology ; Mammary Glands, Human/cytology ; Mammary Glands, Human/metabolism ; Mammary Glands, Human/physiology ; Mice ; Monomeric GTP-Binding Proteins/biosynthesis ; Monomeric GTP-Binding Proteins/genetics ; Neoplasms/pathology ; Oncogenes/genetics ; Phosphorylation ; Proto-Oncogene Proteins/biosynthesis ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-met ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Receptors, Growth Factor/biosynthesis ; Receptors, Growth Factor/genetics ; STAT3 Transcription Factor ; Trans-Activators/biosynthesis ; Trans-Activators/genetics ; Trans-Activators/metabolism ; ras Proteins/biosynthesis ; ras Proteins/genetics
Czasopismo naukowe
Tytuł :
Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation.
Autorzy :
Shen Y; Laboratory of Molecular Cell Biology, The Rockefeller University, New York, New York 10021, USA.
Schlessinger K
Zhu X
Meffre E
Quimby F
Levy DE
Darnell JE Jr
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2004 Jan; Vol. 24 (1), pp. 407-19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
DNA-Binding Proteins/*metabolism
Serine/*metabolism
Trans-Activators/*metabolism
Animals ; DNA-Binding Proteins/genetics ; Fibroblasts/metabolism ; Genes, Lethal ; Genes, Recessive ; Insulin-Like Growth Factor I/metabolism ; Mice ; Mutation ; Phosphorylation ; STAT3 Transcription Factor ; Thymus Gland/metabolism ; Trans-Activators/genetics ; Transcription, Genetic/physiology
Czasopismo naukowe

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