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    Tytuł:
    Immediate versus deferred antiretroviral therapy in HIV-infected patients presenting with acute AIDS-defining events (toxoplasmosis, Pneumocystis jirovecii-pneumonia): a prospective, randomized, open-label multicenter study (IDEAL-study).
    Autorzy:
    Schäfer G; Infectious Diseases Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. .; 1st Medical Department, Section Infectious Diseases & Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. .
    Hoffmann C; ICH Study Center GmbH & Co KG, Hamburg, Germany.
    Arasteh K; Department for Infectious Diseases, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany.
    Schürmann D; Department for Pneumology and Infectious Diseases, Charité Universitätsmedizin, Berlin, Germany.
    Stephan C; 2nd Medical Department, Section Infectious Diseases, University Medical Center, Frankfurt am Main, Germany.
    Jensen B; Department for Gastroenterology, Hepatology, Infectious Diseases, Universitätsklinikum Düsseldorf, Düsseldorf, Germany.
    Stoll M; Department for Immunology and Rheumatology, Medizinische Hochschule Hannover, Hannover, Germany.
    Bogner JR; Department for Infectious Diseases, Mediznische Klinik und Poliklinik IV der Universität München, Munich, Germany.
    Faetkenheuer G; 1st Medical Department, Section Infectious Diseases, Universitätsklinikum Köln, Cologne, Germany.
    Rockstroh J; Medical Department, Section Infectious Diseases, Universitätsklinikum Bonn, Bonn, Germany.
    Klinker H; Department for Infectious Diseases, Julius Maximilians University, Würzburg, Germany.
    Härter G; Department for Infectious Diseases, University Hospital, Ulm, Germany.
    Stöhr A; ifi-Institute for Interdisciplinary Medicine, Hamburg, Germany.
    Degen O; Infectious Diseases Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Freiwald E; Institute for Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Hüfner A; Infectious Diseases Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Jordan S; Infectious Diseases Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; 1st Medical Department, Section Infectious Diseases & Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Schulze Zur Wiesch J; Infectious Diseases Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; 1st Medical Department, Section Infectious Diseases & Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Addo M; 1st Medical Department, Section Infectious Diseases & Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Lohse AW; 1st Medical Department, Section Infectious Diseases & Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    van Lunzen J; ViiV Healthcare, Research Triangle, USA.
    Schmiedel S; Infectious Diseases Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; 1st Medical Department, Section Infectious Diseases & Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
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    Corporate Authors:
    IDEAL study group
    Źródło:
    AIDS research and therapy [AIDS Res Ther] 2019 Nov 15; Vol. 16 (1), pp. 34. Date of Electronic Publication: 2019 Nov 15.
    Typ publikacji:
    Clinical Trial, Phase IV; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antiretroviral Therapy, Highly Active*
    Acquired Immunodeficiency Syndrome/*drug therapy
    Anti-Retroviral Agents/*therapeutic use
    HIV Infections/*drug therapy
    Pneumonia, Pneumocystis/*virology
    Toxoplasmosis/*virology
    AIDS-Related Opportunistic Infections ; Acquired Immunodeficiency Syndrome/complications ; Adult ; Disease Progression ; Drug Administration Schedule ; Female ; Germany ; HIV Infections/complications ; Humans ; Incidence ; Male ; Middle Aged ; Prospective Studies ; Quality of Life
    Czasopismo naukowe
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    Tytuł:
    Immune activation despite suppressive highly active antiretroviral therapy is associated with higher risk of viral blips in HIV-1-infected individuals.
    Autorzy:
    Zoufaly A; Department of Medicine 1/Infectious Diseases Unit, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Kiepe JG
    Hertling S
    Hüfner A
    Degen O
    Feldt T
    Schmiedel S
    Kurowski M
    van Lunzen J
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    Źródło:
    HIV medicine [HIV Med] 2014 Sep; Vol. 15 (8), pp. 449-57. Date of Electronic Publication: 2014 Feb 24.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Lymphocyte Activation*
    Viral Load*
    Anti-Retroviral Agents/*therapeutic use
    Antiretroviral Therapy, Highly Active/*methods
    HIV Infections/*immunology
    HIV-1/*isolation & purification
    Adult ; Aged ; Antigens, CD/analysis ; C-Reactive Protein/analysis ; Cohort Studies ; Female ; HIV Infections/drug therapy ; HIV Infections/pathology ; HIV-1/immunology ; HLA-DR Antigens/analysis ; Humans ; Male ; Middle Aged ; T-Lymphocyte Subsets/chemistry ; T-Lymphocyte Subsets/immunology
    Czasopismo naukowe
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