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Wyszukujesz frazę ""Schumacher, Björn"" wg kryterium: Autor


Tytuł :
DNA Damaged Induced Cell Death in Oocytes.
Autorzy :
Gebel J; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, 60438 Frankfurt, Germany.
Tuppi M; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, 60438 Frankfurt, Germany.
Sänger N; Department for Gynecological Endocrinology and Reproductive Medicine, University Hospital of Bonn, Venusberg-Campus 1, 53217 Bonn, Germany.
Schumacher B; Institute for Genome Stability in Aging and Disease, Cologne Cluster of Excellence in Cellular Stress Responses in Aging-Associated Diseases (CECAD) Research Center, and Center for Molecular Medicine, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
Dötsch V; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, 60438 Frankfurt, Germany.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Dec 03; Vol. 25 (23). Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Death/*genetics
DNA Damage/*genetics
Oocytes/*physiology
Animals ; DNA Breaks, Double-Stranded ; DNA Repair/genetics ; Humans
Czasopismo naukowe
Tytuł :
A C. elegans model for neurodegeneration in Cockayne syndrome.
Autorzy :
Lopes AFC; Institute for Genome Stability in Aging and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
Bozek K; Center for Molecular Medicine (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Robert-Koch-Str. 21, 50931 Cologne, Germany.
Herholz M; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.; Institute for Mitochondrial Diseases and Aging, Medical Faculty, University of Cologne, D-50931 Cologne, Germany.
Trifunovic A; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.; Center for Molecular Medicine (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Robert-Koch-Str. 21, 50931 Cologne, Germany.; Institute for Mitochondrial Diseases and Aging, Medical Faculty, University of Cologne, D-50931 Cologne, Germany.
Rieckher M; Institute for Genome Stability in Aging and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
Schumacher B; Institute for Genome Stability in Aging and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.; Center for Molecular Medicine (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Robert-Koch-Str. 21, 50931 Cologne, Germany.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Nov 04; Vol. 48 (19), pp. 10973-10985.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cockayne Syndrome*/genetics
Cockayne Syndrome*/physiopathology
DNA Damage*
Disease Models, Animal*
Animals ; Caenorhabditis elegans/genetics ; DNA Repair ; DNA Repair Enzymes/genetics ; Mitochondria/pathology ; Mutation ; Poly-ADP-Ribose Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
DNA Damage Response and Metabolic Reprogramming in Health and Disease.
Autorzy :
Chatzidoukaki O; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, Heraklion, Crete, Greece.
Goulielmaki E; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, Heraklion, Crete, Greece.
Schumacher B; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany.
Garinis GA; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, Heraklion, Crete, Greece; Department of Biology, University of Crete, Heraklion, Crete, Greece. Electronic address: .
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Źródło :
Trends in genetics : TIG [Trends Genet] 2020 Oct; Vol. 36 (10), pp. 777-791. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Aging*
Cellular Reprogramming*
Cellular Senescence*
DNA Damage*
DNA Repair*
DNA Repair Enzymes/*metabolism
Neoplasms/*genetics
Animals ; DNA Repair Enzymes/genetics ; Humans ; Mutation
Czasopismo naukowe
Tytuł :
DNA damage responses in ageing.
Autorzy :
da Silva PFL; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany.
Schumacher B; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany.
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Źródło :
Open biology [Open Biol] 2019 Nov 29; Vol. 9 (11), pp. 190168. Date of Electronic Publication: 2019 Nov 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Aging*
DNA Damage*
DNA Repair*
Animals ; Cellular Senescence ; Genomic Instability ; Humans ; Longevity ; Stress, Physiological
Czasopismo naukowe
Tytuł :
ALG-2/AGO-Dependent mir-35 Family Regulates DNA Damage-Induced Apoptosis Through MPK-1/ERK MAPK Signaling Downstream of the Core Apoptotic Machinery in Caenorhabditis elegans .
Autorzy :
Doll MA; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Germany.
Soltanmohammadi N; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Germany.
Schumacher B; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931, Germany bjoern.schumacher@uni-koeln.de.; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Germany.
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Źródło :
Genetics [Genetics] 2019 Sep; Vol. 213 (1), pp. 173-194. Date of Electronic Publication: 2019 Jul 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
DNA Damage*
Argonaute Proteins/*metabolism
Caenorhabditis elegans Proteins/*metabolism
MicroRNAs/*genetics
Mitogen-Activated Protein Kinase 1/*metabolism
Animals ; Argonaute Proteins/genetics ; Caenorhabditis elegans ; Caenorhabditis elegans Proteins/genetics ; MAP Kinase Signaling System ; MicroRNAs/metabolism
Czasopismo naukowe
Tytuł :
Recent advances in understanding the mechanisms determining longevity.
Autorzy :
Bayersdorf R; Institute for Genome Stability in Aging and Disease, Medical Faculty, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
Schumacher B; Institute for Genome Stability in Aging and Disease, Medical Faculty, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
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Źródło :
F1000Research [F1000Res] 2019 Aug 09; Vol. 8. Date of Electronic Publication: 2019 Aug 09 (Print Publication: 2019).
Typ publikacji :
Journal Article; Review
MeSH Terms :
DNA Damage*
Longevity*
Signal Transduction*
Aging/*physiology
Humans
Czasopismo naukowe
Tytuł :
Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells.
Autorzy :
Ou HL; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
Kim CS; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; Paul Gerson Unna Group 'Skin Homeostasis and Ageing,' Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9b, D-50931 Cologne, Germany.
Uszkoreit S; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
Wickström SA; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; Paul Gerson Unna Group 'Skin Homeostasis and Ageing,' Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9b, D-50931 Cologne, Germany; Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, FI-00014 Helsinki, Finland; Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, FI-00014 Helsinki, Finland.
Schumacher B; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany. Electronic address: bjoern.schumacher@uni-koeln.de.
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Źródło :
Developmental cell [Dev Cell] 2019 Jul 22; Vol. 50 (2), pp. 167-183.e8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
Caenorhabditis elegans Proteins/*metabolism
Eukaryotic Initiation Factors/*metabolism
Fibroblast Growth Factors/*metabolism
Germ Cells/*pathology
Tumor Suppressor Protein p53/*metabolism
Animals ; Apoptosis ; Caenorhabditis elegans ; Caenorhabditis elegans Proteins/genetics ; Cells, Cultured ; DNA Repair ; Eukaryotic Initiation Factors/genetics ; Female ; Germ Cells/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Signal Transduction ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
A simple answer to complex questions: Caenorhabditis elegans as an experimental model for examining the DNA damage response and disease genes.
Autorzy :
Rieckher M; Institute for Genome Stability in Ageing and Disease, Cologne Cluster of Excellence in Cellular Stress Responses in Aging-Associated Diseases (CECAD), and Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany.
Bujarrabal A; Institute for Genome Stability in Ageing and Disease, Cologne Cluster of Excellence in Cellular Stress Responses in Aging-Associated Diseases (CECAD), and Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany.
Doll MA; Institute for Genome Stability in Ageing and Disease, Cologne Cluster of Excellence in Cellular Stress Responses in Aging-Associated Diseases (CECAD), and Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany.
Soltanmohammadi N; Institute for Genome Stability in Ageing and Disease, Cologne Cluster of Excellence in Cellular Stress Responses in Aging-Associated Diseases (CECAD), and Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany.
Schumacher B; Institute for Genome Stability in Ageing and Disease, Cologne Cluster of Excellence in Cellular Stress Responses in Aging-Associated Diseases (CECAD), and Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany.
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Źródło :
Journal of cellular physiology [J Cell Physiol] 2018 Apr; Vol. 233 (4), pp. 2781-2790. Date of Electronic Publication: 2017 May 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Genes, Helminth*
Models, Theoretical*
Caenorhabditis elegans/*genetics
DNA Damage/*genetics
Disease/*genetics
Animals ; Biological Assay ; Caenorhabditis elegans/growth & development ; DNA Repair
Czasopismo naukowe
Tytuł :
DNA damage responses and p53 in the aging process.
Autorzy :
Ou HL; Institute for Genome Stability in Aging and Disease, Medical Faculty.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases.; Systems Biology of Aging Cologne, and.
Schumacher B; Institute for Genome Stability in Aging and Disease, Medical Faculty.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases.; Systems Biology of Aging Cologne, and.; Center for Molecular Medicine, University of Cologne, Cologne, Germany.
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Źródło :
Blood [Blood] 2018 Feb 01; Vol. 131 (5), pp. 488-495. Date of Electronic Publication: 2017 Nov 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Aging/*genetics
DNA Damage/*physiology
Tumor Suppressor Protein p53/*physiology
Animals ; Cellular Senescence/genetics ; Humans
Czasopismo naukowe
Tytuł :
Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans.
Autorzy :
Edifizi D; Institute for Genome Stability in Aging and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, Cologne 50931, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases and Systems Biology of Aging Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, Cologne 50931, Germany.
Nolte H; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases and Systems Biology of Aging Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, Cologne 50931, Germany.
Babu V; Institute for Genome Stability in Aging and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, Cologne 50931, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases and Systems Biology of Aging Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, Cologne 50931, Germany.
Castells-Roca L; Institute for Genome Stability in Aging and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, Cologne 50931, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases and Systems Biology of Aging Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, Cologne 50931, Germany.
Mueller MM; Institute for Genome Stability in Aging and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, Cologne 50931, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases and Systems Biology of Aging Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, Cologne 50931, Germany.
Brodesser S; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases and Systems Biology of Aging Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, Cologne 50931, Germany.
Krüger M; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases and Systems Biology of Aging Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, Cologne 50931, Germany; Center for Molecular Medicine, University of Cologne, Robert-Koch-Str. 21, 50931 Cologne, Germany.
Schumacher B; Institute for Genome Stability in Aging and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, Cologne 50931, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases and Systems Biology of Aging Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, Cologne 50931, Germany; Center for Molecular Medicine, University of Cologne, Robert-Koch-Str. 21, 50931 Cologne, Germany. Electronic address: bjoern.schumacher@uni-koeln.de.
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Źródło :
Cell reports [Cell Rep] 2017 Aug 29; Vol. 20 (9), pp. 2026-2043.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Reprogramming*/radiation effects
DNA Damage*
Caenorhabditis elegans/*cytology
Caenorhabditis elegans/*metabolism
Active Transport, Cell Nucleus/radiation effects ; Aging/metabolism ; Animals ; Caenorhabditis elegans/radiation effects ; Caenorhabditis elegans Proteins/metabolism ; Cell Nucleus/metabolism ; Cell Nucleus/radiation effects ; DNA Repair/radiation effects ; Down-Regulation/radiation effects ; Ion Transport/radiation effects ; Lipid Metabolism/radiation effects ; Mutation/genetics ; Phosphoproteins/metabolism ; Proteolysis/radiation effects ; Proteome/metabolism ; Proteomics ; Starvation/metabolism ; Synaptic Transmission/radiation effects ; Transcriptome/genetics ; Transcriptome/radiation effects ; Ultraviolet Rays ; Up-Regulation/radiation effects
Czasopismo naukowe
Tytuł :
Editorial: DNA damage & immunity.
Autorzy :
Garinis GA; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Nikolaou Plastira 100, 70013, Heraklion, Crete, Greece; Department of Biology, University of Crete, Vassilika Vouton, GR71409, Heraklion, Crete, Greece.
Schwer B; Department of Neurological Surgery and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94158, United States.
Schumacher B; Institute for Genome Stability in Aging and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC) and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany. Electronic address: bjoern.schumacher@uni-koeln.de.
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Źródło :
Mechanisms of ageing and development [Mech Ageing Dev] 2017 Jul; Vol. 165 (Pt A), pp. 1-2. Date of Electronic Publication: 2017 Apr 23.
Typ publikacji :
Editorial; Introductory Journal Article
MeSH Terms :
Aging*/genetics
Aging*/immunology
Chromosome Aberrations*
DNA Damage*
DNA, Neoplasm*/genetics
DNA, Neoplasm*/immunology
Neoplasms*/genetics
Neoplasms*/immunology
Neoplasms*/pathology
DNA Repair/*immunology
Animals ; Humans
Czasopismo naukowe
Tytuł :
DNA damage responses and stress resistance: Concepts from bacterial SOS to metazoan immunity.
Autorzy :
Williams AB; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC) and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany. Electronic address: .
Schumacher B; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC) and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany. Electronic address: bjoern.schumacher@uni-koeln.de.
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Źródło :
Mechanisms of ageing and development [Mech Ageing Dev] 2017 Jul; Vol. 165 (Pt A), pp. 27-32. Date of Electronic Publication: 2016 Sep 26.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Archaea*/genetics
Archaea*/metabolism
Bacteria*/genetics
Bacteria*/metabolism
Caenorhabditis elegans*/genetics
Caenorhabditis elegans*/metabolism
DNA Damage*
SOS Response, Genetics/*physiology
Animals ; Humans
Czasopismo naukowe
Tytuł :
Systemic DNA damage responses in aging and diseases.
Autorzy :
Ribezzo F; Institute for Genome Stability in Ageing and Disease, Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases (CECAD) Research Center, Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany.
Shiloh Y; The David and Inez Myers Laboratory for Genetic Research, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Schumacher B; Institute for Genome Stability in Ageing and Disease, Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases (CECAD) Research Center, Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany. Electronic address: bjoern.schumacher@uni-koeln.de.
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Źródło :
Seminars in cancer biology [Semin Cancer Biol] 2016 Jun; Vol. 37-38, pp. 26-35. Date of Electronic Publication: 2016 Jan 07.
Typ publikacji :
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
DNA Repair*
Genomic Instability*
Aging/*genetics
Neoplasms/*genetics
Animals ; Cellular Senescence/genetics ; DNA Breaks, Double-Stranded ; Genetic Association Studies ; Humans ; Immunity, Innate/genetics ; Mutation
Czasopismo naukowe
Tytuł :
p53 in the DNA-Damage-Repair Process.
Autorzy :
Williams AB; Medical Faculty, Institute for Genome Stability in Ageing and Disease, University of Cologne, 50931 Cologne, Germany Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC) and Systems Biology of Ageing Cologne, University of Cologne, 50931 Cologne, Germany.
Schumacher B; Medical Faculty, Institute for Genome Stability in Ageing and Disease, University of Cologne, 50931 Cologne, Germany Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC) and Systems Biology of Ageing Cologne, University of Cologne, 50931 Cologne, Germany.
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Źródło :
Cold Spring Harbor perspectives in medicine [Cold Spring Harb Perspect Med] 2016 May 02; Vol. 6 (5). Date of Electronic Publication: 2016 May 02.
Typ publikacji :
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
DNA Repair/*genetics
Neoplasms/*genetics
Tumor Suppressor Protein p53/*physiology
Animals ; Cell Cycle/genetics ; Genomic Instability ; Humans ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Quality control mechanisms in cellular and systemic DNA damage responses.
Autorzy :
Ermolaeva MA; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany. Electronic address: .
Dakhovnik A; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
Schumacher B; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany. Electronic address: bjoern.schumacher@uni-koeln.de.
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Źródło :
Ageing research reviews [Ageing Res Rev] 2015 Sep; Vol. 23 (Pt A), pp. 3-11. Date of Electronic Publication: 2015 Jan 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Aging/*genetics
Aging/*physiology
DNA Damage/*genetics
DNA Damage/*physiology
Animals ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Genome, Human/genetics ; Genome, Human/physiology ; Genomic Instability ; Humans ; Protein Biosynthesis/genetics ; Protein Biosynthesis/physiology ; Quality Control
Czasopismo naukowe
Tytuł :
Longevity through DNA damage tolerance.
Autorzy :
Castells-Roca L; a Institute for Genome Stability in Ageing and Disease; Medical Faculty ; University of Cologne ; Cologne , Germany.
Mueller MM
Schumacher B
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Źródło :
Cell cycle (Georgetown, Tex.) [Cell Cycle] 2015; Vol. 14 (4), pp. 467-8.
Typ publikacji :
Editorial
MeSH Terms :
Models, Biological*
DNA Damage/*physiology
Longevity/*physiology
Signal Transduction/*physiology
Animals ; Humans
Opinia redakcyjna
Tytuł :
DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage.
Autorzy :
Mueller MM; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD) Research Center and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
Castells-Roca L; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD) Research Center and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
Babu V; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD) Research Center and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
Ermolaeva MA; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD) Research Center and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
Müller RU; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD) Research Center and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, 50937 Cologne, Germany.
Frommolt P; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD) Research Center and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.; Cologne Center for Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany.
Williams AB; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD) Research Center and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
Greiss S; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD) Research Center and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
Schneider JI; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD) Research Center and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
Benzing T; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD) Research Center and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, 50937 Cologne, Germany.
Schermer B; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD) Research Center and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.; Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, 50937 Cologne, Germany.
Schumacher B; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD) Research Center and Systems Biology of Ageing Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
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Źródło :
Nature cell biology [Nat Cell Biol] 2014 Dec; Vol. 16 (12), pp. 1168-1179. Date of Electronic Publication: 2014 Nov 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging*
DNA Damage*
Gene Expression Regulation, Developmental*
Caenorhabditis elegans/*growth & development
Caenorhabditis elegans Proteins/*genetics
DNA-Binding Proteins/*genetics
Transcription Factors/*genetics
Animals ; Animals, Genetically Modified ; Caenorhabditis elegans Proteins/biosynthesis ; DNA Repair/genetics ; DNA-Binding Proteins/biosynthesis ; Forkhead Transcription Factors ; Herbicides/pharmacology ; Paraquat/pharmacology ; Signal Transduction/genetics ; Transcription Factors/biosynthesis
Czasopismo naukowe
Tytuł :
Impact of genomic damage and ageing on stem cell function.
Autorzy :
Behrens A; Mammalian Genetics Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK, and the School of Medicine, King's College London, Guy's Campus, London, SE1 1UL, UK.
van Deursen JM; Department of Pediatric and Adolescent Medicine and the Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
Rudolph KL; Leibniz Institute of Age Research, Fritz Lipmann Institute e.V., Jena, 07745, Germany, and the Research Group on Molecular Aging, Faculty of Medicine, Friedrich-Schiller-University, Jena, Germany.
Schumacher B; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931 Cologne, and the Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, and Systems Biology of Cologne, University of Cologne, Zülpicher Str. 47a, 50674 Cologne, Germany.
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Źródło :
Nature cell biology [Nat Cell Biol] 2014 Mar; Vol. 16 (3), pp. 201-7.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
DNA Damage*
Adult Stem Cells/*physiology
Aneuploidy ; Animals ; Cells, Cultured ; Cellular Senescence ; DNA Repair ; Genome, Human ; Humans ; Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Systemic DNA damage responses: organismal adaptations to genome instability.
Autorzy :
Ermolaeva MA; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany.
Schumacher B; Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, 50931 Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany; Systems Biology of Ageing Cologne, University of Cologne, 50937 Cologne, Germany. Electronic address: bjoern.schumacher@uni-koeln.de.
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Źródło :
Trends in genetics : TIG [Trends Genet] 2014 Mar; Vol. 30 (3), pp. 95-102. Date of Electronic Publication: 2014 Jan 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
DNA Damage*
Adaptation, Physiological/*genetics
Genomic Instability/*genetics
Animals ; Humans ; Inflammation/genetics ; Inflammation/pathology ; Neoplasms/genetics ; Neoplasms/pathology ; Regeneration/genetics
Czasopismo naukowe
Tytuł :
DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance.
Autorzy :
Ermolaeva MA; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases, Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany.
Segref A
Dakhovnik A
Ou HL
Schneider JI
Utermöhlen O
Hoppe T
Schumacher B
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Źródło :
Nature [Nature] 2013 Sep 19; Vol. 501 (7467), pp. 416-20. Date of Electronic Publication: 2013 Aug 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*/genetics
Immunity, Innate*/genetics
Adaptation, Physiological/*physiology
Caenorhabditis elegans/*physiology
Germ Cells/*immunology
Germ Cells/*metabolism
Stress, Physiological/*immunology
Animals ; Caenorhabditis elegans/cytology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/immunology ; Caenorhabditis elegans Proteins/metabolism ; Enzyme Activation ; Genomic Instability/genetics ; Germ Cells/enzymology ; Hot Temperature ; MAP Kinase Signaling System ; Mitogen-Activated Protein Kinase 1/metabolism ; Oxidative Stress ; Proteasome Endopeptidase Complex/metabolism ; Proteolysis ; Ubiquitin/metabolism
Czasopismo naukowe

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