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Wyszukujesz frazę ""Schupp JC"" wg kryterium: Autor


Tytuł:
Correction: iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects.
Autorzy:
Liu Y; Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA.
Zhao J; Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA.
Adams TS; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, 06520, USA.
Wang N; Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA.
Schupp JC; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, 06520, USA.; Department of Respiratory Medicine, Hannover Medical School and Biomedical Research in End-Stage and Obstructive Lung Disease Hannover, German Center for Lung Research (DZL), Hannover, Germany.
Wu W; Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA.; Meta Platforms, Inc, Cambridge, USA.
McDonough JE; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, 06520, USA.
Chupp GL; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, 06520, USA.
Kaminski N; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, 06520, USA.
Wang Z; Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA. .
Yan X; Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA. .; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, 06520, USA. .
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Źródło:
BMC bioinformatics [BMC Bioinformatics] 2023 Oct 19; Vol. 24 (1), pp. 394. Date of Electronic Publication: 2023 Oct 19.
Typ publikacji:
Published Erratum
Tytuł:
iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects.
Autorzy:
Liu Y; Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA.
Zhao J; Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA.
Adams TS; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, 06520, USA.
Wang N; Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA.
Schupp JC; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, 06520, USA.; Department of Respiratory Medicine, Hannover Medical School and Biomedical Research in End-Stage and Obstructive Lung Disease Hannover, German Center for Lung Research (DZL), Hannover, Germany.
Wu W; Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA.; Meta Platforms, Inc, Cambridge, USA.
McDonough JE; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, 06520, USA.
Chupp GL; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, 06520, USA.
Kaminski N; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, 06520, USA.
Wang Z; Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA. .
Yan X; Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA. .; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, 06520, USA. .
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Źródło:
BMC bioinformatics [BMC Bioinformatics] 2023 Aug 22; Vol. 24 (1), pp. 318. Date of Electronic Publication: 2023 Aug 22.
Typ publikacji:
Journal Article
MeSH Terms:
Models, Statistical*
Transcriptome*
Humans ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł:
Genetic and geographic influence on phenotypic variation in European sarcoidosis patients.
Autorzy:
Freitag-Wolf S; Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany.
Schupp JC; Department of Pneumology, Faculty of Medicine, University Medical Centre, Freiburg, Germany.; Department of Respiratory Medicine, Hannover Medical School, German Center for Lung Research (DZL), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.
Frye BC; Department of Pneumology, Faculty of Medicine, University Medical Centre, Freiburg, Germany.
Fischer A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Anwar R; Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany.
Kieszko R; Department of Pneumonology, Oncology and Allergology, Medical University of Lublin, Lublin, Poland.
Mihailović-Vučinić V; Department of Pneumology, University Hospital, Belgrade, Serbia.
Milanowski J; Department of Pneumonology, Oncology and Allergology, Medical University of Lublin, Lublin, Poland.
Jovanovic D; Department of Pneumology, University Hospital, Belgrade, Serbia.
Zissel G; Department of Pneumology, Faculty of Medicine, University Medical Centre, Freiburg, Germany.
Bargagli E; Respiratory Diseases and Lung Transplant Unit, University Hospital, Siena, Italy.
Rottoli P; Respiratory Diseases and Lung Transplant Unit, University Hospital, Siena, Italy.
Bumbacea D; Department of Cardio-Thoracic Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Jonkers R; Pulmonology Department, Academic Medical Center Amsterdam, Amsterdam, Netherlands.
Ho LP; Oxford Sarcoidosis Service, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, United Kingdom.
Gaede KI; Medical Hospital, Research Center Borstel, Borstel, Germany.
Dubaniewicz A; Department of Pulmonology, Medical University of Gdansk, Gdansk, Poland.
Marshall BG; Department of Respiratory Medicine, University Hospital, Southampton, United Kingdom.
Günther A; Department of Pneumology and Intensive Care, University Hospital, Giessen, Germany.
Petrek M; Faculty of Medicine and Dentistry, Palacký University and University Hospital Olomouc, Olomouc, Czechia.
Keane MP; Division of Pulmonary and Critical Care Medicine, University College Dublin and St Vincent's University Hospital, Dublin, Ireland.
Haraldsdottir SO; Landspitali, University Hospital, Reykjavik, Iceland.
Bonella F; Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen, Universitätsklinik Essen, Essen, Germany.
Grah C; Hospital Berlin-Havelhöhe, Berlin, Germany.
Peroš-Golubičić T; Pulmonary Department, University Hospital Jordanovac, Zagreb, Croatia.
Kadija Z; Foundation IRCCS Policlinico San Matteo - Pulmonology Unit, Pavia, Italy.
Pabst S; Department of Pneumology, University Hospital, Bonn, Germany.
Grohé C; Evangelische Lungenklinik Berlin, Berlin, Germany.
Strausz J; National Koranyi Institute, Budapest, Hungary.
Safrankova M; Thomayer Hospital and 1st Faculty of Medicine, Charles University, Praha, Czechia.
Millar A; Pulmonary Department, University Hospital, Bristol, United Kingdom.
Homolka J; Prague General Hospital, Charles University, Prague, Czechia.
Wuyts WA; Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), University Hospital, Leuven, Belgium.
Spencer LG; Liverpool Interstitial Lung Disease Service, Aintree Chest Centre, Liverpool University Hospitals NHS FT, Liverpool, United Kingdom.
Pfeifer M; Department of Pneumology, University Hospital Regensburg, Regensburg, Germany.
Valeyre D; Groupe Hospitalier Avicenne-Jean Verdier-René Muret, Service de Pneumologie, Bobigny, France.
Poletti V; Pulmonary Unit, Department of Thoracic Diseases, Azienda USL Romagna, GB Morgagni-L-Pierantoni Hospital, Forlì, Italy.
Wirtz H; Department of Pneumology, University Hospital Leipzig, Leipzig, Germany.
Prasse A; Department of Pneumology, Faculty of Medicine, University Medical Centre, Freiburg, Germany.; Department of Respiratory Medicine, Hannover Medical School, German Center for Lung Research (DZL), Hannover, Germany.
Schreiber S; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.; Department of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany.
Dempfle A; Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany.
Müller-Quernheim J; Department of Pneumology, Faculty of Medicine, University Medical Centre, Freiburg, Germany.
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Źródło:
Frontiers in medicine [Front Med (Lausanne)] 2023 Aug 09; Vol. 10, pp. 1218106. Date of Electronic Publication: 2023 Aug 09 (Print Publication: 2023).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Calcineurin-inhibitor free immunosuppression after lung transplantation - a single center case-control study in 51 patients converted to Mechanistic Target of Rapamycin (mTOR) inhibitors.
Autorzy:
Gottlieb J; Respiratory Medicine, Hannover Medical School, Hannover, Germany.; German Center for Lung Research (DZL), Hannover, Germany.
Fischer B; Respiratory Medicine, Hannover Medical School, Hannover, Germany.
Schupp JC; Respiratory Medicine, Hannover Medical School, Hannover, Germany.
Golpon H; Respiratory Medicine, Hannover Medical School, Hannover, Germany.; German Center for Lung Research (DZL), Hannover, Germany.
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Źródło:
PloS one [PLoS One] 2023 May 18; Vol. 18 (5), pp. e0284653. Date of Electronic Publication: 2023 May 18 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Calcineurin*
Lung Transplantation*
Adult ; Humans ; Retrospective Studies ; Case-Control Studies ; MTOR Inhibitors ; Calcineurin Inhibitors/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Sirolimus/therapeutic use ; Glomerular Filtration Rate ; Prednisolone ; Immunosuppression Therapy ; TOR Serine-Threonine Kinases ; Graft Rejection/prevention & control
Czasopismo naukowe
Tytuł:
microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis.
Autorzy:
Ahangari F; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Price NL; Vascular Biology and Therapeutics Program, Yale Center for Molecular and System Metabolism, Department of Comparative Medicine, and Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, Maryland, USA.
Malik S; Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut, USA.
Chioccioli M; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Bärnthaler T; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
Adams TS; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Kim J; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Pradeep SP; Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut, USA.
Ding S; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Cosmos C Jr; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Rose KS; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
McDonough JE; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Aurelien NR; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.; Department of Internal Medicine, Weill Cornell Hospital Medicine, New York, New York, USA.
Ibarra G; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.; Life Span Medical Group, Department of Internal Medicine, Rhode Island Hospital, Providence, Rhode Island, USA.
Omote N; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Schupp JC; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
DeIuliis G; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Villalba Nunez JA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Sharma L; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Ryu C; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Dela Cruz CS; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Liu X; Center for Cellular and Molecular Imaging (CCMI), Department of Cell Biology, Yale School of Medicine, New Haven, Connecticut, USA.
Prasse A; Department of Pneumology, University of Hannover, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.
Rosas I; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Bahal R; Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut, USA.
Fernández-Hernando C; Vascular Biology and Therapeutics Program, Yale Center for Molecular and System Metabolism, Department of Comparative Medicine, and Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.
Kaminski N; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
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Źródło:
JCI insight [JCI Insight] 2023 Feb 22; Vol. 8 (4). Date of Electronic Publication: 2023 Feb 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Autophagy*/genetics
Idiopathic Pulmonary Fibrosis*/metabolism
Macrophages*/metabolism
MicroRNAs*/genetics
Animals ; Humans ; Mice ; Bleomycin/adverse effects ; Homeostasis ; Mitochondria/metabolism
Czasopismo naukowe
Tytuł:
Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis.
Autorzy:
Öz HH; Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Cheng EC; Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Di Pietro C; Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Tebaldi T; Department of Hematology, Yale School of Medicine, New Haven, CT, USA; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.
Biancon G; Department of Hematology, Yale School of Medicine, New Haven, CT, USA; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA.
Zeiss C; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.
Zhang PX; Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.
Huang PH; Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Esquibies SS; Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Britto CJ; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Schupp JC; Department of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA; Department of Respiratory Medicine, Hannover Medical School and Biomedical Research in End-stage and Obstructive Lung Disease Hannover, German Lung Research Center (DZL), Hannover, Germany.
Murray TS; Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Halene S; Department of Hematology, Yale School of Medicine, New Haven, CT, USA; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA.
Krause DS; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
Egan ME; Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
Bruscia EM; Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2022 Dec 13; Vol. 41 (11), pp. 111797.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Cystic Fibrosis*/pathology
Pneumonia*/pathology
Humans ; Mice ; Animals ; Monocytes/metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator ; Lung/pathology ; Inflammation/pathology ; Receptors, Chemokine/metabolism ; Macrophages/metabolism ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł:
Airway basal cells show a dedifferentiated KRT17 Phenotype and promote fibrosis in idiopathic pulmonary fibrosis.
Autorzy:
Jaeger B; Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.; German Center for Lung Research, BREATH, Hannover, Germany.
Schupp JC; German Center for Lung Research, BREATH, Hannover, Germany.; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Pulmonology, Hannover Medical School, Hannover, Germany.
Plappert L; Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.; German Center for Lung Research, BREATH, Hannover, Germany.
Terwolbeck O; Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.; German Center for Lung Research, BREATH, Hannover, Germany.
Artysh N; Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.; German Center for Lung Research, BREATH, Hannover, Germany.; Department of Pulmonology, Hannover Medical School, Hannover, Germany.
Kayser G; Institute of Surgical Pathology, University Medical Center, Freiburg, Germany.
Engelhard P; Department of Pneumology, University Medical Center, Freiburg, Germany.
Adams TS; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Zweigerdt R; Leibniz Research Laboratories for Biotechnology and Artificial Organs, Hannover Medical School, Hannover, Germany.
Kempf H; Leibniz Research Laboratories for Biotechnology and Artificial Organs, Hannover Medical School, Hannover, Germany.
Lienenklaus S; Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany.
Garrels W; Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany.
Nazarenko I; Institute for Infection Prevention and Hospital Epidemiology, Medical Center - University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner Site Freiburg and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jonigk D; German Center for Lung Research, BREATH, Hannover, Germany.; Institute of Pathology, Hannover Medical School, Hannover, Germany.
Wygrecka M; Department of Biochemistry, Faculty of Medicine, Justus Liebig University, Gießen, Germany.
Klatt D; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Schambach A; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Kaminski N; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Prasse A; Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany. .; German Center for Lung Research, BREATH, Hannover, Germany. .; Department of Pulmonology, Hannover Medical School, Hannover, Germany. .
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Źródło:
Nature communications [Nat Commun] 2022 Sep 26; Vol. 13 (1), pp. 5637. Date of Electronic Publication: 2022 Sep 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Idiopathic Pulmonary Fibrosis*/pathology
Animals ; Disease Models, Animal ; Fibroblasts/metabolism ; Fibrosis ; Humans ; Lung/pathology ; Mice ; Phenotype
Czasopismo naukowe
Tytuł:
FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis.
Autorzy:
Preisendörfer S; Institute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Member of the German Center of Lung Research (DZL), Helmholtz-Zentrum München, 81377 Munich, Germany.
Ishikawa Y; Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, OR 97239, USA.
Hennen E; Institute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Member of the German Center of Lung Research (DZL), Helmholtz-Zentrum München, 81377 Munich, Germany.
Winklmeier S; Institute of Clinical Neuroimmunology, Biomedical Center and LMU Klinikum, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.
Schupp JC; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT 06520, USA.; Department of Respiratory Medicine, Hannover Medical School, Biomedical Research in End-Stage and Obstructive Lung Disease Hannover, Member of the German Center for Lung Research (DZL), 30625 Hannover, Germany.
Knüppel L; Institute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Member of the German Center of Lung Research (DZL), Helmholtz-Zentrum München, 81377 Munich, Germany.
Fernandez IE; Institute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Member of the German Center of Lung Research (DZL), Helmholtz-Zentrum München, 81377 Munich, Germany.; Department of Medicine V, LMU Klinikum, Ludwig-Maximilians-Universität München, Member of the German Center of Lung Research (DZL), 81377 Munich, Germany.
Binzenhöfer L; Institute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Member of the German Center of Lung Research (DZL), Helmholtz-Zentrum München, 81377 Munich, Germany.
Flatley A; Monoclonal Antibody Core Facility, Institute for Diabetes and Obesity, Helmholtz-Zentrum München, 85764 Neuherberg, Germany.
Juan-Guardela BM; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Ruppert C; Department of Internal Medicine, Medizinische Klinik II, Member of the German Center of Lung Research (DZL), 35392 Giessen, Germany.
Guenther A; Department of Internal Medicine, Medizinische Klinik II, Member of the German Center of Lung Research (DZL), 35392 Giessen, Germany.
Frankenberger M; Institute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Member of the German Center of Lung Research (DZL), Helmholtz-Zentrum München, 81377 Munich, Germany.
Hatz RA; Thoraxchirurgisches Zentrum, Klinik für Allgemeine-, Viszeral-, Transplantations-, Gefäß- und Thoraxchirurgie, LMU Klinikum, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.; Asklepios Fachkliniken München-Gauting, 82131 Gauting, Germany.
Kneidinger N; Department of Medicine V, LMU Klinikum, Ludwig-Maximilians-Universität München, Member of the German Center of Lung Research (DZL), 81377 Munich, Germany.
Behr J; Department of Medicine V, LMU Klinikum, Ludwig-Maximilians-Universität München, Member of the German Center of Lung Research (DZL), 81377 Munich, Germany.
Feederle R; Monoclonal Antibody Core Facility, Institute for Diabetes and Obesity, Helmholtz-Zentrum München, 85764 Neuherberg, Germany.
Schepers A; Monoclonal Antibody Core Facility, Institute for Diabetes and Obesity, Helmholtz-Zentrum München, 85764 Neuherberg, Germany.
Hilgendorff A; Institute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Member of the German Center of Lung Research (DZL), Helmholtz-Zentrum München, 81377 Munich, Germany.
Kaminski N; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
Meinl E; Institute of Clinical Neuroimmunology, Biomedical Center and LMU Klinikum, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.
Bächinger HP; Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, OR 97239, USA.
Eickelberg O; Institute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Member of the German Center of Lung Research (DZL), Helmholtz-Zentrum München, 81377 Munich, Germany.
Staab-Weijnitz CA; Institute of Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive, Member of the German Center of Lung Research (DZL), Helmholtz-Zentrum München, 81377 Munich, Germany.
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Źródło:
Cells [Cells] 2022 Apr 14; Vol. 11 (8). Date of Electronic Publication: 2022 Apr 14.
Typ publikacji:
Journal Article
MeSH Terms:
Idiopathic Pulmonary Fibrosis*
Tacrolimus Binding Proteins*/metabolism
Humans ; Immunoglobulin G ; Peptidylprolyl Isomerase/metabolism ; Plasma Cells/metabolism
Czasopismo naukowe
Tytuł:
Computation and visualization of cell-cell signaling topologies in single-cell systems data using Connectome.
Autorzy:
Raredon MSB; Department of Biomedical Engineering, Yale University, New Haven, CT, USA. .; Medical Scientist Training Program, Yale School of Medicine, New Haven, CT, USA. .
Yang J; Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
Garritano J; Medical Scientist Training Program, Yale School of Medicine, New Haven, CT, USA.; Applied Mathematics Program, Yale University, New Haven, CT, USA.
Wang M; Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
Kushnir D; NOKIA Bell-Laboratories, Murray Hill, NJ, USA.
Schupp JC; Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Adams TS; Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Greaney AM; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
Leiby KL; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.; Medical Scientist Training Program, Yale School of Medicine, New Haven, CT, USA.
Kaminski N; Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Kluger Y; Applied Mathematics Program, Yale University, New Haven, CT, USA.; Department of Pathology, Yale University, New Haven, CT, USA.; Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
Levchenko A; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.; Yale Systems Biology Institute, Yale University, West Haven, CT, USA.
Niklason LE; Department of Biomedical Engineering, Yale University, New Haven, CT, USA. .; Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA. .
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Źródło:
Scientific reports [Sci Rep] 2022 Mar 09; Vol. 12 (1), pp. 4187. Date of Electronic Publication: 2022 Mar 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Connectome*
Brain/diagnostic imaging ; Brain/physiology ; Ligands ; RNA ; Signal Transduction
Czasopismo naukowe
Tytuł:
Characterization of the COPD alveolar niche using single-cell RNA sequencing.
Autorzy:
Sauler M; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA. .
McDonough JE; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA. .
Adams TS; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Kothapalli N; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Barnthaler T; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
Werder RB; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA.; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.; QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia.
Schupp JC; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Respiratory Medicine, Hannover Medical School and Biomedical Research in End-stage and Obstructive Lung Disease Hannover, German Lung Research Center (DZL), Hannover, Germany.
Nouws J; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Robertson MJ; Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA.
Coarfa C; Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA.
Yang T; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chioccioli M; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Omote N; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Cosme C Jr; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Poli S; Department of Internal Medicine, Mount Sinai Medical Center, Miami, FL, USA.
Ayaub EA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Chu SG; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jensen KH; Intomics A/S, Lyngby, Denmark.
Gomez JL; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Britto CJ; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Raredon MSB; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.; Medical Scientist Training Program, Yale School of Medicine, New Haven, CT, USA.
Niklason LE; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
Wilson AA; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA.; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.
Timshel PN; Intomics A/S, Lyngby, Denmark.
Kaminski N; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Rosas IO; Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA.
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Źródło:
Nature communications [Nat Commun] 2022 Jan 25; Vol. 13 (1), pp. 494. Date of Electronic Publication: 2022 Jan 25.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Alveolar Epithelial Cells/*metabolism
Lung/*metabolism
Pulmonary Disease, Chronic Obstructive/*genetics
RNA-Seq/*methods
Single-Cell Analysis/*methods
A549 Cells ; Alveolar Epithelial Cells/classification ; Animals ; Cells, Cultured ; Cluster Analysis ; Epithelial Cells/metabolism ; Female ; Gene Expression Profiling/methods ; Gene Regulatory Networks ; Humans ; Lung/cytology ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Pulmonary Disease, Chronic Obstructive/pathology ; Signal Transduction/genetics ; Mice
Czasopismo naukowe
Tytuł:
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19.
Autorzy:
Unterman A; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA. .; Pulmonary Institute, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel. .
Sumida TS; Department of Neurology, School of Medicine, Yale University, New Haven, CT, USA. .; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA. .
Nouri N; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Center for Medical Informatics, Yale School of Medicine, New Haven, CT, USA.; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Yan X; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.; Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA.
Zhao AY; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.; Department of Genetics, Yale School of Medicine, New Haven, CT, USA.; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Gasque V; Department of Computer Science, Yale University, New Haven, CT, USA.; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Schupp JC; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.; Department of Respiratory Medicine, Hannover Medical School and Biomedical Research in End-stage and Obstructive Lung Disease Hannover, German Lung Research Center (DZL), Hannover, Germany.
Asashima H; Department of Neurology, School of Medicine, Yale University, New Haven, CT, USA.; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
Liu Y; Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA.
Cosme C Jr; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.
Deng W; Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA.
Chen M; Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA.
Raredon MSB; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.; Medical Scientist Training Program, Yale School of Medicine, New Haven, CT, USA.
Hoehn KB; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
Wang G; Yale Center for Genome Analysis/Keck Biotechnology Resource Laboratory, Department of Molecular Biophysics and Biochemistry, Yale School of Medicine, New Haven, CT, USA.
Wang Z; Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA.
DeIuliis G; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.
Ravindra NG; Department of Computer Science, Yale University, New Haven, CT, USA.; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Li N; Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA.; SJTU-Yale Joint Center for Biostatistics and Data Science, Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Castaldi C; Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA.
Wong P; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
Fournier J; School of Medicine, Yale University, New Haven, CT, USA.
Bermejo S; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.
Sharma L; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.
Casanovas-Massana A; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Vogels CBF; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Wyllie AL; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Grubaugh ND; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Melillo A; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
Meng H; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
Stein Y; Pulmonary Institute, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
Minasyan M; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.
Mohanty S; Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT, USA.
Ruff WE; Department of Neurology, School of Medicine, Yale University, New Haven, CT, USA.; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
Cohen I; Department of Neurology, School of Medicine, Yale University, New Haven, CT, USA.; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
Raddassi K; Department of Neurology, School of Medicine, Yale University, New Haven, CT, USA.; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
Niklason LE; Departments of Anesthesiology & Biomedical Engineering, Yale University, New Haven, CT, USA.
Ko AI; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Montgomery RR; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Farhadian SF; Department of Neurology, School of Medicine, Yale University, New Haven, CT, USA.; Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT, USA.
Iwasaki A; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Shaw AC; Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT, USA.
van Dijk D; Department of Computer Science, Yale University, New Haven, CT, USA.; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Zhao H; Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA.; Department of Genetics, Yale School of Medicine, New Haven, CT, USA.; SJTU-Yale Joint Center for Biostatistics and Data Science, Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.; Inter-Departmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
Kleinstein SH; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Inter-Departmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
Hafler DA; Department of Neurology, School of Medicine, Yale University, New Haven, CT, USA.; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
Kaminski N; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.
Dela Cruz CS; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.; West Haven Veterans Affair Medical Center, West Haven, CT, USA.
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Corporate Authors:
Yale IMPACT Research Team
Źródło:
Nature communications [Nat Commun] 2022 Jan 21; Vol. 13 (1), pp. 440. Date of Electronic Publication: 2022 Jan 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Adaptive Immunity/*immunology
COVID-19/*immunology
Gene Expression Profiling/*methods
Immunity, Innate/*immunology
SARS-CoV-2/*immunology
Single-Cell Analysis/*methods
Adaptive Immunity/drug effects ; Adaptive Immunity/genetics ; Aged ; Antibodies, Monoclonal, Humanized/therapeutic use ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; COVID-19/genetics ; Cells, Cultured ; Female ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/immunology ; Humans ; Immunity, Innate/drug effects ; Immunity, Innate/genetics ; Male ; RNA-Seq/methods ; Receptors, Antigen, B-Cell/genetics ; Receptors, Antigen, B-Cell/immunology ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/immunology ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; COVID-19 Drug Treatment
Czasopismo naukowe
Tytuł:
FeV1 and BMI influence King's Sarcoidosis Questionnaire score in sarcoidosis patients.
Autorzy:
Frye BC; Department of Pneumology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany. .
Potasso L; Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland.
Farin-Glattacker E; Section of Health Care Research and Rehabilitation Research, Faculty of Medicine,, Medical Center-University of Freiburg, Freiburg, Germany.
Birring S; Division of Asthma, Allergy and Lung Biology, King's College London, London, UK.
Müller-Quernheim J; Department of Pneumology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany.
Schupp JC; Department of Pneumology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany.; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA.
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Źródło:
BMC pulmonary medicine [BMC Pulm Med] 2021 Dec 03; Vol. 21 (1), pp. 395. Date of Electronic Publication: 2021 Dec 03.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Health Status*
Quality of Life*
Obesity/*complications
Sarcoidosis, Pulmonary/*complications
Adult ; Aged ; Body Mass Index ; Female ; Forced Expiratory Volume ; Humans ; Lung/physiopathology ; Male ; Middle Aged ; Respiratory Function Tests ; Surveys and Questionnaires
Czasopismo naukowe
Tytuł:
A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds.
Autorzy:
Yuan Y; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.; Department of Anesthesiology, Yale University, New Haven, CT, United States.
Leiby KL; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.; Department of Biomedical Engineering, Yale University, New Haven, CT, United States.; Medical Scientist Training Program, Yale University, New Haven, CT, United States.
Greaney AM; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.; Department of Biomedical Engineering, Yale University, New Haven, CT, United States.
Raredon MSB; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.; Department of Biomedical Engineering, Yale University, New Haven, CT, United States.; Medical Scientist Training Program, Yale University, New Haven, CT, United States.
Qian H; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.; Department of Anesthesiology, Yale University, New Haven, CT, United States.
Schupp JC; Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, United States.; Department of Respiratory Medicine, Hannover Medical School and Biomedical Research in End-stage and Obstructive Lung Disease Hannover, German Lung Research Center (DZL), Hannover, Germany.
Engler AJ; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.; Department of Biomedical Engineering, Yale University, New Haven, CT, United States.
Baevova P; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.; Department of Anesthesiology, Yale University, New Haven, CT, United States.
Adams TS; Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, United States.
Kural MH; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.; Department of Anesthesiology, Yale University, New Haven, CT, United States.
Wang J; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.; Department of Anesthesiology, Yale University, New Haven, CT, United States.
Obata T; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.; Department of Anesthesiology, Yale University, New Haven, CT, United States.
Yoder MC; Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, United States.
Kaminski N; Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, United States.
Niklason LE; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.; Department of Anesthesiology, Yale University, New Haven, CT, United States.; Department of Biomedical Engineering, Yale University, New Haven, CT, United States.
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Źródło:
Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2021 Nov 19; Vol. 9, pp. 760309. Date of Electronic Publication: 2021 Nov 19 (Print Publication: 2021).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Abnormal FeV1 and body mass index are associated with impaired cough-related quality of life in sarcoidosis patients.
Autorzy:
Frye BC; Department of Pneumology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany. Electronic address: .
Potasso L; Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland.
Farin E; Section of Health Care Research and Rehabilitation Research, Faculty of Medicine, Medical Center- University of Freiburg, Freiburg, Germany.
Fichtner U; Section of Health Care Research and Rehabilitation Research, Faculty of Medicine, Medical Center- University of Freiburg, Freiburg, Germany.
Birring S; Division of Asthma, Allergy and Lung Biology, King's College London, London, UK.
Müller-Quernheim J; Department of Pneumology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany.
Schupp JC; Department of Pneumology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Killianstrasse 5, 79106, Freiburg, Germany; Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA.
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Źródło:
Respiratory medicine [Respir Med] 2021 Nov; Vol. 188, pp. 106600. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Body Mass Index*
Forced Expiratory Volume*
Quality of Life*
Cough/*physiopathology
Sarcoidosis/*physiopathology
Adult ; Female ; Humans ; Male ; Retrospective Studies
Czasopismo naukowe
Tytuł:
Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic Data.
Autorzy:
Manning EP; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, United States.; VA Connecticut Healthcare System, West Haven, CT, United States.
Ramachandra AB; Department of Biomedical Engineering, Yale University, New Haven, CT, United States.
Schupp JC; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, United States.; Respiratory Medicine, Hannover Medical School, Hannover, Germany.
Cavinato C; Department of Biomedical Engineering, Yale University, New Haven, CT, United States.
Raredon MSB; Department of Biomedical Engineering, Yale University, New Haven, CT, United States.; Vascular Biology and Therapeutics Program, Yale University, New Haven, CT, United States.; Department of Anesthesiology, Yale School of Medicine, New Haven, CT, United States.
Bärnthaler T; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, United States.; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
Cosme C Jr; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, United States.
Singh I; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, United States.
Tellides G; VA Connecticut Healthcare System, West Haven, CT, United States.; Vascular Biology and Therapeutics Program, Yale University, New Haven, CT, United States.; Department of Surgery, Yale School of Medicine, New Haven, CT, United States.
Kaminski N; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, United States.
Humphrey JD; Department of Biomedical Engineering, Yale University, New Haven, CT, United States.; Vascular Biology and Therapeutics Program, Yale University, New Haven, CT, United States.
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Źródło:
Frontiers in physiology [Front Physiol] 2021 Sep 14; Vol. 12, pp. 726253. Date of Electronic Publication: 2021 Sep 14 (Print Publication: 2021).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity.
Autorzy:
Bui LT; Translational Genomics Research Institute, Phoenix, AZ, USA.
Winters NI; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Chung MI; Translational Genomics Research Institute, Phoenix, AZ, USA.
Joseph C; Respiratory Medicine NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK.
Gutierrez AJ; Translational Genomics Research Institute, Phoenix, AZ, USA.
Habermann AC; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Adams TS; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Schupp JC; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Poli S; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Peter LM; Translational Genomics Research Institute, Phoenix, AZ, USA.
Taylor CJ; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Blackburn JB; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Richmond BW; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Veterans Affairs Medical Center, Nashville, TN, USA.
Nicholson AG; National Heart and Lung Institute, Imperial College, London, UK.; Department of Histopathology, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
Rassl D; Pathology Research, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.
Wallace WA; Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh, UK.; Division of Pathology, Edinburgh University Medical School, Edinburgh, UK.
Rosas IO; Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Jenkins RG; Respiratory Medicine NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK.
Kaminski N; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Kropski JA; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Veterans Affairs Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Banovich NE; Translational Genomics Research Institute, Phoenix, AZ, USA. .
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Corporate Authors:
Human Cell Atlas Lung Biological Network
Źródło:
Nature communications [Nat Commun] 2021 Jul 14; Vol. 12 (1), pp. 4314. Date of Electronic Publication: 2021 Jul 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Transcriptome*
Virus Internalization*
Lung Diseases/*genetics
SARS-CoV-2/*physiology
Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/pathology ; Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/genetics ; COVID-19/pathology ; Chronic Disease ; Humans ; Idiopathic Pulmonary Fibrosis/genetics ; Idiopathic Pulmonary Fibrosis/pathology ; Immunity, Innate/genetics ; Inflammation/genetics ; Lung/metabolism ; Lung/pathology ; Lung Diseases/pathology ; SARS-CoV-2/pathogenicity ; Virus Replication/genetics
Czasopismo naukowe
Tytuł:
Single-cell characterization of a model of poly I:C-stimulated peripheral blood mononuclear cells in severe asthma.
Autorzy:
Chen A; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street (S419 TAC), New Haven, CT, 06520-8057, USA.
Diaz-Soto MP; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street (S419 TAC), New Haven, CT, 06520-8057, USA.
Sanmamed MF; Department of Oncology, Clínica Universidad de Navarra, Pamplona, Spain.; Program of Immunology and Immunotherapy, Center for Applied Medical Research, University of Navarra, Pamplona, Spain.
Adams T; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street (S419 TAC), New Haven, CT, 06520-8057, USA.
Schupp JC; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street (S419 TAC), New Haven, CT, 06520-8057, USA.
Gupta A; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street (S419 TAC), New Haven, CT, 06520-8057, USA.
Britto C; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street (S419 TAC), New Haven, CT, 06520-8057, USA.
Sauler M; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street (S419 TAC), New Haven, CT, 06520-8057, USA.
Yan X; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street (S419 TAC), New Haven, CT, 06520-8057, USA.
Liu Q; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street (S419 TAC), New Haven, CT, 06520-8057, USA.
Nino G; Division of Pediatric Pulmonary and Sleep Medicine, Children's National Hospital, Department of Pediatrics, George Washington University, Washington, DC, USA.
Cruz CSD; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street (S419 TAC), New Haven, CT, 06520-8057, USA.
Chupp GL; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street (S419 TAC), New Haven, CT, 06520-8057, USA.
Gomez JL; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street (S419 TAC), New Haven, CT, 06520-8057, USA. .
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Źródło:
Respiratory research [Respir Res] 2021 Apr 26; Vol. 22 (1), pp. 122. Date of Electronic Publication: 2021 Apr 26.
Typ publikacji:
Journal Article
MeSH Terms:
Single-Cell Analysis*
Asthma/*immunology
Leukocytes, Mononuclear/*drug effects
Poly I-C/*pharmacology
Adult ; Asthma/diagnosis ; Asthma/genetics ; Case-Control Studies ; Cells, Cultured ; Female ; Flow Cytometry ; Gene Expression Profiling ; Humans ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Male ; Middle Aged ; Phenotype ; RNA-Seq ; Severity of Illness Index ; Time Factors ; Transcriptome ; Young Adult
Czasopismo naukowe
Tytuł:
Bronchoalveolar Lavage Fluid Reflects a T H 1-CD21 B-Cell Interaction in CVID-Related Interstitial Lung Disease.
Autorzy:
Friedmann D; Divison of Immunodeficiency, Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany.
Unger S; Divison of Immunodeficiency, Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Keller B; Divison of Immunodeficiency, Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Rakhmanov M; Divison of Immunodeficiency, Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Human Genetics and Laboratory Diagnostics (AHC), Martinsried, Germany.
Goldacker S; Divison of Immunodeficiency, Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Zissel G; Department of Pneumology, University Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Frye BC; Department of Pneumology, University Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Schupp JC; Department of Pneumology, University Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, United States.
Prasse A; Department of Respiratory Medicine, Hannover Medical School and Biomedical Research in End-stage and Obstructive Lung Disease Hannover, German Lung Research Center (DZL), Hannover, Germany.; Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.
Warnatz K; Divison of Immunodeficiency, Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
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Źródło:
Frontiers in immunology [Front Immunol] 2021 Feb 05; Vol. 11, pp. 616832. Date of Electronic Publication: 2021 Feb 05 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
B-Lymphocytes/*immunology
Bronchoalveolar Lavage Fluid/*immunology
Common Variable Immunodeficiency/*immunology
Lung Diseases, Interstitial/*immunology
Th1 Cells/*immunology
Bronchoalveolar Lavage Fluid/cytology ; Common Variable Immunodeficiency/complications ; Humans ; Lung Diseases, Interstitial/diagnosis ; Retrospective Studies ; Sarcoidosis/immunology
Czasopismo naukowe
Tytuł:
Long noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation state.
Autorzy:
Omote N; Pulmonary, Critical Care and Sleep Medicine Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Sakamoto K; Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Li Q; Pulmonary, Critical Care and Sleep Medicine Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Schupp JC; Pulmonary, Critical Care and Sleep Medicine Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Adams T; Pulmonary, Critical Care and Sleep Medicine Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Ahangari F; Pulmonary, Critical Care and Sleep Medicine Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Chioccioli M; Pulmonary, Critical Care and Sleep Medicine Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
DeIuliis G; Pulmonary, Critical Care and Sleep Medicine Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Hashimoto N; Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hasegawa Y; Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Respiratory Medicine, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Kaminski N; Pulmonary, Critical Care and Sleep Medicine Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
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Źródło:
Physiological reports [Physiol Rep] 2021 Feb; Vol. 9 (3), pp. e14727.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Differentiation*
Bronchi/*metabolism
Epithelial Cells/*metabolism
RNA, Long Noncoding/*metabolism
Bronchi/cytology ; Cell Movement ; Cell Proliferation ; Cells, Cultured ; Cytoskeletal Proteins/genetics ; Cytoskeletal Proteins/metabolism ; Gene Expression Regulation ; Humans ; Phenotype ; RNA, Long Noncoding/genetics ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; SOXB1 Transcription Factors/genetics ; SOXB1 Transcription Factors/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł:
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis.
Autorzy:
Adams TS; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Schupp JC; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Poli S; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ayaub EA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Neumark N; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.; Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
Ahangari F; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Chu SG; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Raby BA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Pulmonary Medicine, Boston's Children Hospital, Harvard Medical School, Boston, MA, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
DeIuliis G; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Januszyk M; NuMedii, Inc., San Mateo, CA, USA.
Duan Q; NuMedii, Inc., San Mateo, CA, USA.
Arnett HA; NuMedii, Inc., San Mateo, CA, USA.
Siddiqui A; NuMedii, Inc., San Mateo, CA, USA.
Washko GR; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Homer R; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Pathology and Laboratory Medicine Service and VA CT HealthCare System, West Haven, CT, USA.
Yan X; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Rosas IO; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kaminski N; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
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Źródło:
Science advances [Sci Adv] 2020 Jul 08; Vol. 6 (28), pp. eaba1983. Date of Electronic Publication: 2020 Jul 08 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Idiopathic Pulmonary Fibrosis*/genetics
Pulmonary Disease, Chronic Obstructive*
Endothelial Cells ; Humans ; Lung ; RNA-Seq
Czasopismo naukowe

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