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Wyszukujesz frazę ""Secretin"" wg kryterium: Temat


Tytuł :
Secretin-Enhanced MRCP: How and Why- AJR Expert Panel Narrative Review.
Autorzy :
Swensson J; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N University Blvd, Rm 0663, Indianapolis, IN 46202.
Zaheer A; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N University Blvd, Rm 0663, Indianapolis, IN 46202.; Department of Medicine, Pancreatitis Center, Johns Hopkins Medical Institutions, Baltimore, MD.
Conwell D; Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH.
Sandrasegaran K; Department of Diagnostic Radiology, Mayo Clinic, Scottsdale, AZ.
Manfredi R; Department of Diagnostic Imaging, Oncological Radiotherapy, and Hematology, Diagnostic Imaging Area, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Tirkes T; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N University Blvd, Rm 0663, Indianapolis, IN 46202.
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Źródło :
AJR. American journal of roentgenology [AJR Am J Roentgenol] 2021 May; Vol. 216 (5), pp. 1139-1149. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Cholangiopancreatography, Magnetic Resonance/*methods
Image Enhancement/*methods
Pancreatic Diseases/*diagnostic imaging
Secretin/*pharmacology
Expert Testimony ; Humans ; Pancreas/diagnostic imaging ; Periodicals as Topic ; Secretin/administration & dosage
Czasopismo naukowe
Tytuł :
Endoscopic Pancreatic Function Testing (ePFT) in Children: A Position Paper From the NASPGHAN Pancreas Committee.
Autorzy :
Patel N; Pediatric Gastroenterology, Center for Digestive Health and Nutrition, Arnold Palmer Hospital for Children of Orlando Health, Orlando, FL.
Sellers ZM; Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University, Palo Alto, CA.
Grover A; Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, MA.
Liu QY; Digestive Disease Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Maqbool A; Children's Hospital of Philadelphia, University of Pennsylvania, Perleman School of Medicine, Philadelphia, PA.
Morinville VD; Division of Pediatric Gastroenterology and Nutrition, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada.
Abu-El-Haija M; Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center.; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH.
Husain SZ; Pediatric Gastroenterology, Hepatology, and Nutrition, Stanford University, Palo Alto, CA.
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Źródło :
Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2021 Jan 01; Vol. 72 (1), pp. 144-150.
Typ publikacji :
Journal Article
MeSH Terms :
Gastroenterology*
Secretin*
Adult ; Child ; Endoscopy ; Humans ; Pancreas ; Pancreatic Function Tests
Czasopismo naukowe
Tytuł :
Rational development of a high-affinity secretin receptor antagonist.
Autorzy :
Dong M; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ 85259, United States.
Harikumar KG; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ 85259, United States.
Raval SR; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ 85259, United States.
Milburn JE; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ 85259, United States.
Clark C; School of Molecular Sciences, Arizona State University, Tempe, AZ 85281, United States.
Alcala-Torano R; School of Molecular Sciences, Arizona State University, Tempe, AZ 85281, United States.
Mobarec JC; Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK.
Reynolds CA; Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK.
Ghirlanda G; School of Molecular Sciences, Arizona State University, Tempe, AZ 85281, United States.
Christopoulos A; Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, 3052 Victoria, Australia.
Wootten D; Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, 3052 Victoria, Australia.
Sexton PM; Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, 3052 Victoria, Australia.
Miller LJ; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ 85259, United States. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Jul; Vol. 177, pp. 113929. Date of Electronic Publication: 2020 Mar 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Peptides/*chemistry
Receptors, G-Protein-Coupled/*antagonists & inhibitors
Receptors, G-Protein-Coupled/*chemistry
Receptors, Gastrointestinal Hormone/*antagonists & inhibitors
Receptors, Gastrointestinal Hormone/*chemistry
Secretin/*analogs & derivatives
Alanine/metabolism ; Amino Acid Sequence ; Animals ; Binding Sites ; CHO Cells ; Cricetulus ; Glucagon-Like Peptide-1 Receptor/metabolism ; Humans ; Hydrophobic and Hydrophilic Interactions ; Ligands ; Models, Molecular ; Peptides/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Receptors, Calcitonin/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Gastrointestinal Hormone/metabolism ; Secretin/metabolism
Czasopismo naukowe
Tytuł :
Accuracy of a novel noninvasive secretin-enhanced MRCP severity index scoring system for diagnosis of chronic pancreatitis: correlation with EUS-based Rosemont criteria.
Autorzy :
Souza D; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Alessandrino F; Division of Body MRI, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA. .; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA. .
Ketwaroo GA; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.; Department of Medicine, Division of Gastroenterology and Hepatology, Baylor College School of Medicine, 2002 Holcombe Blvd., Houston, TX, 77030, USA.
Sawhney M; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.
Mortele KJ; Division of Body MRI, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.
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Źródło :
La Radiologia medica [Radiol Med] 2020 Sep; Vol. 125 (9), pp. 816-826. Date of Electronic Publication: 2020 Apr 07.
Typ publikacji :
Evaluation Study; Journal Article
MeSH Terms :
Gastrointestinal Agents*
Secretin*
Severity of Illness Index*
Cholangiopancreatography, Magnetic Resonance/*methods
Pancreatitis, Chronic/*diagnostic imaging
Adult ; Aged ; Area Under Curve ; Endosonography ; Female ; Humans ; Male ; Middle Aged ; Pancreatitis, Chronic/classification ; Pancreatitis, Chronic/pathology ; ROC Curve ; Retrospective Studies ; Sensitivity and Specificity ; Young Adult
Czasopismo naukowe
Tytuł :
Corticotropin-Releasing Factor: An Ancient Peptide Family Related to the Secretin Peptide Superfamily.
Autorzy :
Michalec OM; Department of Cell and Systems Biology, University of Toronto - St. George Campus, Toronto, ON, Canada.
Chang BSW; Department of Cell and Systems Biology, University of Toronto - St. George Campus, Toronto, ON, Canada.
Lovejoy NR; Department of Biological Sciences, University of Toronto Scarborough, Toronto, ON, Canada.
Lovejoy DA; Department of Cell and Systems Biology, University of Toronto - St. George Campus, Toronto, ON, Canada.
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Źródło :
Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2020 Aug 27; Vol. 11, pp. 529. Date of Electronic Publication: 2020 Aug 27 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Databases, Factual*
Evolution, Molecular*
Multigene Family*
Phylogeny*
Corticotropin-Releasing Hormone/*metabolism
Secretin/*metabolism
Amino Acid Sequence ; Corticotropin-Releasing Hormone/genetics ; Humans ; Secretin/genetics ; Sequence Homology
Czasopismo naukowe
Tytuł :
Secretin-induced Duodenal Aspirate of Pancreatic Juice (SIDA): Utility of Commercial Genetic Analysis.
Autorzy :
Simpson RE; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, U.S.A.
Yip-Schneider M; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, U.S.A.; Indiana University Health Pancreatic Cyst and Cancer Early Detection Center, Indianapolis, IN, U.S.A.
Flick KF; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, U.S.A.
Soufi M; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, U.S.A.
Ceppa EP; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, U.S.A.; Indiana University Health Pancreatic Cyst and Cancer Early Detection Center, Indianapolis, IN, U.S.A.
Al-Haddad MA; Indiana University Health Pancreatic Cyst and Cancer Early Detection Center, Indianapolis, IN, U.S.A.; Department of Medicine, Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN, U.S.A.
Easler JJ; Department of Medicine, Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN, U.S.A.
Sherman S; Department of Medicine, Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN, U.S.A.
Dewitt JM; Department of Medicine, Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN, U.S.A.
Schmidt CM; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, U.S.A. .; Indiana University Health Pancreatic Cyst and Cancer Early Detection Center, Indianapolis, IN, U.S.A.; Department of Biochemistry/Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, U.S.A.; Walther Oncology Center, Indianapolis, IN, U.S.A.; Indiana University Simon Cancer Center, Indianapolis, IN, U.S.A.
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Źródło :
Anticancer research [Anticancer Res] 2020 Aug; Vol. 40 (8), pp. 4215-4221.
Typ publikacji :
Journal Article
MeSH Terms :
Duodenum/*metabolism
Genetic Testing/*methods
Pancreatic Juice/*metabolism
Pancreatic Neoplasms/*genetics
Secretin/*genetics
Aged ; DNA/genetics ; Databases, Genetic ; Female ; Humans ; Male ; Middle Aged ; Secretin/metabolism
Czasopismo naukowe
Tytuł :
Structure and dynamics of the active Gs-coupled human secretin receptor.
Autorzy :
Dong M; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ, 85259, USA.
Deganutti G; School of Biological Sciences, University of Essex, Colchester, CO4 3SQ, UK.; Centre for Sport, Exercise and Life Sciences, Faculty of Health and Life Sciences, Alison Gingell Building, Coventry University, CV1 2DS, Coventry, UK.
Piper SJ; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
Liang YL; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
Khoshouei M; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany.; Novartis Institutes for Biomedical Research, Novartis Pharma AG, 4002, Basel, Switzerland.
Belousoff MJ; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
Harikumar KG; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ, 85259, USA.
Reynolds CA; School of Biological Sciences, University of Essex, Colchester, CO4 3SQ, UK.
Glukhova A; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
Furness SGB; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
Christopoulos A; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
Danev R; Graduate School of Medicine, University of Tokyo, N415, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan.
Wootten D; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia. .
Sexton PM; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia. .
Miller LJ; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ, 85259, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 18; Vol. 11 (1), pp. 4137. Date of Electronic Publication: 2020 Aug 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Dynamics Simulation*
GTP-Binding Protein alpha Subunits, Gs/*chemistry
Receptors, G-Protein-Coupled/*chemistry
Receptors, Gastrointestinal Hormone/*chemistry
Secretin/*chemistry
Amino Acid Sequence ; Animals ; Binding Sites/genetics ; Cell Line ; Cricetinae ; Cryoelectron Microscopy ; Crystallography, X-Ray ; Cysteine/chemistry ; Cysteine/metabolism ; GTP-Binding Protein alpha Subunits, Gs/ultrastructure ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Insecta ; Models, Molecular ; Protein Binding ; Protein Domains/genetics ; Protein Structure, Secondary ; Receptors, G-Protein-Coupled/metabolism ; Receptors, G-Protein-Coupled/ultrastructure ; Receptors, Gastrointestinal Hormone/metabolism ; Receptors, Gastrointestinal Hormone/ultrastructure ; Secretin/metabolism
Czasopismo naukowe
Tytuł :
Bacterial secretins: Mechanisms of assembly and membrane targeting.
Autorzy :
Silva YRO; Brazilian Biosciences National Laboratory (LNBio), CNPEM, Campinas, São Paulo, Brazil.; Departamento de Genética, Evolução, Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Contreras-Martel C; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France.
Macheboeuf P; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France.
Dessen A; Brazilian Biosciences National Laboratory (LNBio), CNPEM, Campinas, São Paulo, Brazil.; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France.
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Źródło :
Protein science : a publication of the Protein Society [Protein Sci] 2020 Apr; Vol. 29 (4), pp. 893-904. Date of Electronic Publication: 2020 Feb 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Bacteria/*chemistry
Bacterial Outer Membrane Proteins/*chemistry
Secretin/*chemistry
Bacteria/genetics ; Bacterial Outer Membrane Proteins/genetics ; Bacterial Outer Membrane Proteins/metabolism ; Cryoelectron Microscopy ; Models, Molecular ; Secretin/genetics ; Secretin/metabolism
Czasopismo naukowe
Tytuł :
Exogenous Secretin Improves Parenteral Nutrition-associated Liver Disease in Rats.
Autorzy :
Cao X; Pediatric Surgery Department.
Feng F; Hepatobiliary Department, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Liu X; Pediatric Surgery Department.
Sun C; Pediatric Surgery Department.
Yang X; Pediatric Surgery Department.
Fang Y; Pediatric Surgery Department.
Li S; Pediatric Surgery Department.
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Źródło :
Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2020 Apr; Vol. 70 (4), pp. 430-435.
Typ publikacji :
Journal Article
MeSH Terms :
Liver Diseases*/etiology
Liver Diseases*/prevention & control
Secretin*
Animals ; Humans ; Liver ; Male ; Parenteral Nutrition ; Parenteral Nutrition, Total/adverse effects ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Loss of secretin results in systemic and pulmonary hypertension with cardiopulmonary pathologies in mice.
Autorzy :
Zaw AM; School of Biological Sciences, The University of Hong Kong, Hong Kong, China.
Sekar R; School of Biological Sciences, The University of Hong Kong, Hong Kong, China.
Mak SOK; School of Biological Sciences, The University of Hong Kong, Hong Kong, China.
Law HKW; Department of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong, China. .
Chow BKC; School of Biological Sciences, The University of Hong Kong, Hong Kong, China. .
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Źródło :
Scientific reports [Sci Rep] 2019 Oct 02; Vol. 9 (1), pp. 14211. Date of Electronic Publication: 2019 Oct 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood Pressure/*physiology
Hypertension/*physiopathology
Hypertension, Pulmonary/*physiopathology
Lung/*pathology
Myocardium/*pathology
Secretin/*deficiency
Airway Remodeling ; Aldosterone/analysis ; Angiotensin II/blood ; Animals ; Hemodynamics ; Hypertension/blood ; Hypertension/genetics ; Hypertension, Pulmonary/blood ; Hypertension, Pulmonary/genetics ; Lung/chemistry ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myocardium/chemistry ; Nitric Oxide/blood ; Renin/blood ; Secretin/genetics ; Telemetry ; Vascular Endothelial Growth Factor A/analysis ; Vasopressins/blood
Czasopismo naukowe
Tytuł :
Distribution and Functional Implication of Secretin in Multiple Brain Regions.
Autorzy :
Wang R; Joint International Research Laboratory of CNS Regeneration, GHM Institute of CNS Regeneration, Jinan University, Guangzhou, China.
Chow BKC; School of Biological Sciences, University of Hong Kong, Hong Kong SAR, China. .
Zhang L; Joint International Research Laboratory of CNS Regeneration, GHM Institute of CNS Regeneration, Jinan University, Guangzhou, China. .
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Źródło :
Journal of molecular neuroscience : MN [J Mol Neurosci] 2019 Jul; Vol. 68 (3), pp. 485-493. Date of Electronic Publication: 2018 Jun 07.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cerebellum/*metabolism
Hypothalamus/*metabolism
Secretin/*metabolism
Sensorimotor Cortex/*metabolism
Animals ; Cerebellum/physiology ; Cognition ; Emotions ; Humans ; Hypothalamus/physiology ; Movement ; Secretin/genetics ; Sensorimotor Cortex/physiology
Czasopismo naukowe
Tytuł :
Secretin Prevents Apoptosis in the Developing Cerebellum Through Bcl-2 and Bcl-xL.
Autorzy :
Wang L; School of Life Sciences, Guangzhou University, Guangzhou, China.
Zhang L; GHM Institute for CNS Regeneration, Jinan University, Guangzhou, China. .
Chow BKC; School of Biological Sciences, The University of Hong Kong, Hong Kong, SAR, Hong Kong. .
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Źródło :
Journal of molecular neuroscience : MN [J Mol Neurosci] 2019 Jul; Vol. 68 (3), pp. 494-503. Date of Electronic Publication: 2019 Mar 14.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Cerebellum/*metabolism
Proto-Oncogene Proteins c-bcl-2/*metabolism
Secretin/*metabolism
bcl-X Protein/*metabolism
Animals ; Cerebellum/growth & development ; Cyclic AMP Response Element-Binding Protein/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Mice ; Mice, Inbred C57BL ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Proto-Oncogene Proteins c-bcl-2/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Secretin/genetics ; Signal Transduction ; bcl-X Protein/genetics
Czasopismo naukowe
Tytuł :
Multiplexed analysis of the secretin-like GPCR-RAMP interactome.
Autorzy :
Lorenzen E; Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, 1230 York Ave., New York, NY 10065, USA.
Dodig-Crnković T; Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 171 65 Solna, Sweden.
Kotliar IB; Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, 1230 York Ave., New York, NY 10065, USA.; Tri-Institutional PhD Program in Chemical Biology, New York, NY 10065, USA.
Pin E; Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 171 65 Solna, Sweden.
Ceraudo E; Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, 1230 York Ave., New York, NY 10065, USA.
Vaughan RD; Center for Clinical and Translational Science, The Rockefeller University, 1230 York Ave., New York, NY 10065, USA.
Uhlèn M; Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 171 65 Solna, Sweden.; AlbaNova University Center, School Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 106 91 Stockholm, Sweden.
Huber T; Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, 1230 York Ave., New York, NY 10065, USA.
Schwenk JM; Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 171 65 Solna, Sweden.
Sakmar TP; Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, 1230 York Ave., New York, NY 10065, USA.; Department of Neurobiology, Care Sciences and Society, Section for Neurogeriatrics, Karolinska Institutet, 171 64 Solna, Sweden.
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Źródło :
Science advances [Sci Adv] 2019 Sep 18; Vol. 5 (9), pp. eaaw2778. Date of Electronic Publication: 2019 Sep 18 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Interaction Mapping*
Receptor Activity-Modifying Proteins/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Secretin/*metabolism
HEK293 Cells ; Humans ; Receptor Activity-Modifying Proteins/genetics ; Receptors, G-Protein-Coupled/genetics ; Secretin/genetics
Czasopismo naukowe
Tytuł :
Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.
Autorzy :
Kennedy L; Research, Central Texas Veterans Health Care System, Temple, Texas, USA.; Department of Medical Physiology, Texas A&M University, College of Medicine, Temple, Texas, USA.
Francis H; Research, Central Texas Veterans Health Care System, Temple, Texas, USA.; Department of Medical Physiology, Texas A&M University, College of Medicine, Temple, Texas, USA.; Baylor Scott & White Health Digestive Disease Research Center, Baylor Scott and White Health, Temple, Texas, USA.
Invernizzi P; Humanitas Clinical and Research Center, Rozzano (MI), Italy.
Venter J; Department of Medical Physiology, Texas A&M University, College of Medicine, Temple, Texas, USA.
Wu N; Department of Medical Physiology, Texas A&M University, College of Medicine, Temple, Texas, USA.
Carbone M; Humanitas Clinical and Research Center, Rozzano (MI), Italy.
Gershwin ME; Division of Rheumatology, Allergy, and Clinical Immunology, University of California-Davis, Davis, California, USA.
Bernuzzi F; Humanitas Clinical and Research Center, Rozzano (MI), Italy.
Franchitto A; Eleonora Lorillard Spencer Cenci Foundation, Rome, Italy.
Alvaro D; Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Marzioni M; Clinic of Gastroenterology and Hepatology, Universita Politecnica delle Marche, Ancona, Italy.
Onori P; Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy.
Gaudio E; Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy.
Sybenga A; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Fabris L; Department of Molecular Medicine, University of Padua School of Medicine, Padua, Italy.; Digestive Disease Section, Yale University School of Medicine, New Haven, Connecticut, USA.
Meng F; Research, Central Texas Veterans Health Care System, Temple, Texas, USA.; Baylor Scott & White Health Digestive Disease Research Center, Baylor Scott and White Health, Temple, Texas, USA.
Glaser S; Department of Medical Physiology, Texas A&M University, College of Medicine, Temple, Texas, USA.; Baylor Scott & White Health Digestive Disease Research Center, Baylor Scott and White Health, Temple, Texas, USA.
Alpini G; Research, Central Texas Veterans Health Care System, Temple, Texas, USA.; Department of Medical Physiology, Texas A&M University, College of Medicine, Temple, Texas, USA.; Baylor Scott & White Health Digestive Disease Research Center, Baylor Scott and White Health, Temple, Texas, USA.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2019 Sep; Vol. 33 (9), pp. 10269-10279. Date of Electronic Publication: 2019 Jun 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Biliary Tract Diseases/*pathology
Inflammation/*pathology
Liver Cirrhosis/*pathology
Liver Cirrhosis, Biliary/*complications
Receptor, Transforming Growth Factor-beta Type II/*physiology
Receptors, G-Protein-Coupled/*metabolism
Receptors, Gastrointestinal Hormone/*metabolism
Secretin/*metabolism
Animals ; Biliary Tract Diseases/etiology ; Biliary Tract Diseases/metabolism ; Case-Control Studies ; Female ; Humans ; Inflammation/etiology ; Inflammation/metabolism ; Liver Cirrhosis/etiology ; Liver Cirrhosis/metabolism ; Liver Cirrhosis, Biliary/metabolism ; Liver Cirrhosis, Biliary/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, G-Protein-Coupled/genetics ; Receptors, Gastrointestinal Hormone/genetics ; Secretin/genetics ; Signal Transduction ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta1/metabolism
Czasopismo naukowe
Tytuł :
Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein.
Autorzy :
Fukuhara S; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan; Department of Family Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Kobayashi K; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Kusakizako T; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Iida W; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Kato M; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Shihoya W; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. Electronic address: .
Nureki O; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Dec 17; Vol. 533 (4), pp. 861-866. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Heterotrimeric GTP-Binding Proteins/*chemistry
Receptors, G-Protein-Coupled/*chemistry
Receptors, Gastrointestinal Hormone/*chemistry
Cryoelectron Microscopy ; GTP-Binding Protein alpha Subunits, Gs/chemistry ; GTP-Binding Protein alpha Subunits, Gs/genetics ; Heterotrimeric GTP-Binding Proteins/genetics ; Humans ; Ligands ; Models, Molecular ; Protein Binding ; Protein Engineering ; Secretin/chemistry
Czasopismo naukowe
Tytuł :
Functional Role of the Secretin/Secretin Receptor Signaling During Cholestatic Liver Injury.
Autorzy :
Wu N; Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, IN.
Baiocchi L; Liver Unit, Department of Medicine, University of Rome 'Tor Vergata,', Rome, Italy.
Zhou T; Department of Medical Physiology, Texas A&M University, Bryan, TX.
Kennedy L; Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, IN.
Ceci L; Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, IN.
Meng F; Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, IN.; Gastroenterology, Medicine, Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis, IN.
Sato K; Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, IN.
Wu C; Department of Nutrition, Texas A&M University, College Station, TX.
Ekser B; Division of Transplant Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN.
Kyritsi K; Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, IN.
Kundu D; Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, IN.
Chen L; Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, IN.
Meadows V; Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, IN.
Franchitto A; Eleonora Lorillard Spencer Cenci Foundation, Rome, Italy.
Alvaro D; Department of Internal Medicine and Medical Specialties, Rome, Italy.
Onori P; Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy.
Gaudio E; Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy.
Lenci I; Liver Unit, Department of Medicine, University of Rome 'Tor Vergata,', Rome, Italy.
Francis H; Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, IN.; Gastroenterology, Medicine, Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis, IN.
Glaser S; Department of Medical Physiology, Texas A&M University, Bryan, TX.
Alpini G; Hepatology and Gastroenterology, Medicine, Indiana University, Indianapolis, IN.; Gastroenterology, Medicine, Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis, IN.
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Źródło :
Hepatology (Baltimore, Md.) [Hepatology] 2020 Dec; Vol. 72 (6), pp. 2219-2227. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Bile Ducts/*metabolism
Cholestasis/*pathology
Liver/*pathology
Receptors, G-Protein-Coupled/*metabolism
Receptors, Gastrointestinal Hormone/*metabolism
Secretin/*metabolism
Animals ; Bile/metabolism ; Bile Acids and Salts/metabolism ; Chronic Disease ; Disease Models, Animal ; Epithelium/pathology ; Humans ; Signal Transduction
Czasopismo naukowe
Tytuł :
CryoEM structure of the type IVa pilus secretin required for natural competence in Vibrio cholerae.
Autorzy :
Weaver SJ; Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd, Pasadena, CA, 91125, USA.; Howard Hughes Medical Institute, David Geffen School of Medicine, Departments of Biological Chemistry and Physiology, University of California Los Angeles, 615 Charles E Young Drive South, Los Angeles, CA, 90095, USA.
Ortega DR; Division of Biology and Biological Engineering and Howard Hughes Medical Institute, California Institute of Technology, 1200 E. California Blvd, Pasadena, CA, 91125, USA.
Sazinsky MH; Department of Chemistry, Pomona College, 333N. College Way, Claremont, CA, 91711, USA.
Dalia TN; Department of Biology, Indiana University, 107S. Indiana Avenue, Bloomington, IN, 47405, USA.
Dalia AB; Department of Biology, Indiana University, 107S. Indiana Avenue, Bloomington, IN, 47405, USA.
Jensen GJ; Division of Biology and Biological Engineering and Howard Hughes Medical Institute, California Institute of Technology, 1200 E. California Blvd, Pasadena, CA, 91125, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 08; Vol. 11 (1), pp. 5080. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy*
Bacterial Secretion Systems/*ultrastructure
Fimbriae, Bacterial/*ultrastructure
Secretin/*chemistry
Vibrio cholerae/*metabolism
Vibrio cholerae/*ultrastructure
Cysteine/genetics ; Membrane Proteins/ultrastructure ; Models, Molecular ; Mutation/genetics ; Phylogeny ; Protein Domains ; Transformation, Bacterial
Czasopismo naukowe
Tytuł :
Structure and assembly of pilotin-dependent and -independent secretins of the type II secretion system.
Autorzy :
Howard SP; Dept. Biochemistry, Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Estrozi LF; Univ Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France.
Bertrand Q; Univ Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France.
Contreras-Martel C; Univ Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France.
Strozen T; Dept. Biochemistry, Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Job V; Univ Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France.
Martins A; Univ Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France.
Fenel D; Univ Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France.
Schoehn G; Univ Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France.
Dessen A; Univ Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France.; Brazilian Biosciences National Laboratory (LNBio), CNPEM, Campinas, São Paulo, Brazil.
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Źródło :
PLoS pathogens [PLoS Pathog] 2019 May 13; Vol. 15 (5), pp. e1007731. Date of Electronic Publication: 2019 May 13 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Outer Membrane Proteins/*metabolism
Lipoproteins/*metabolism
Secretin/*chemistry
Type II Secretion Systems/*chemistry
Vibrio vulnificus/*metabolism
Amino Acid Sequence ; Bacterial Outer Membrane Proteins/chemistry ; Cryoelectron Microscopy ; Crystallography, X-Ray ; Lipoproteins/chemistry ; Models, Molecular ; Protein Conformation ; Secretin/metabolism ; Sequence Homology ; Type II Secretion Systems/metabolism ; Vibrio vulnificus/growth & development
Czasopismo naukowe
Tytuł :
Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation.
Autorzy :
Li Y; Chair for Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany; EKFZ - Else Kröner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany.
Schnabl K; Chair for Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany; EKFZ - Else Kröner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany; ZIEL - Institute for Food & Health, Technical University of Munich, Freising, Germany.
Gabler SM; Chair for Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany; EKFZ - Else Kröner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany; ZIEL - Institute for Food & Health, Technical University of Munich, Freising, Germany.
Willershäuser M; Chair for Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany; EKFZ - Else Kröner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany.
Reber J; Institute for Biological and Medical Imaging (IBMI), Helmholtz Zentrum München, Neuherberg; Chair for Biological Imaging, Technical University of Munich, Munich, Germany.
Karlas A; Institute for Biological and Medical Imaging (IBMI), Helmholtz Zentrum München, Neuherberg; Chair for Biological Imaging, Technical University of Munich, Munich, Germany.
Laurila S; Turku PET Centre, University of Turku, Turku, Finland.
Lahesmaa M; Turku PET Centre, University of Turku, Turku, Finland.
U Din M; Turku PET Centre, University of Turku, Turku, Finland.
Bast-Habersbrunner A; Chair for Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany; EKFZ - Else Kröner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany.
Virtanen KA; Turku PET Centre, University of Turku, Turku, Finland.
Fromme T; Chair for Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany; EKFZ - Else Kröner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany; ZIEL - Institute for Food & Health, Technical University of Munich, Freising, Germany.
Bolze F; Chair for Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany; EKFZ - Else Kröner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany.
O'Farrell LS; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, USA.
Alsina-Fernandez J; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, USA.
Coskun T; Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, USA.
Ntziachristos V; Institute for Biological and Medical Imaging (IBMI), Helmholtz Zentrum München, Neuherberg; Chair for Biological Imaging, Technical University of Munich, Munich, Germany.
Nuutila P; Turku PET Centre, University of Turku, Turku, Finland; Department of Endocrinology, Turku University Hospital, Turku, Finland.
Klingenspor M; Chair for Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany; EKFZ - Else Kröner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany; ZIEL - Institute for Food & Health, Technical University of Munich, Freising, Germany. Electronic address: .
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Źródło :
Cell [Cell] 2018 Nov 29; Vol. 175 (6), pp. 1561-1574.e12. Date of Electronic Publication: 2018 Nov 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Eating*
Thermogenesis*
Adipocytes, Brown/*metabolism
Adipose Tissue, Brown/*metabolism
Secretin/*metabolism
Adipocytes, Brown/cytology ; Adipose Tissue, Brown/cytology ; Animals ; HEK293 Cells ; Humans ; Lipolysis ; Mice ; Mice, Knockout ; Mice, Obese ; Secretin/genetics
Czasopismo naukowe
Tytuł :
Efficacy and safety of pancreatic juice cytology by using synthetic secretin in the diagnosis of pancreatic ductal adenocarcinoma.
Autorzy :
Takeda Y; Faculty of Medicine, Medicine and Clinical Science, Tottori University, Yonago, Japan.
Matsumoto K; Faculty of Medicine, Medicine and Clinical Science, Tottori University, Yonago, Japan.
Kurumi H; Faculty of Medicine, Medicine and Clinical Science, Tottori University, Yonago, Japan.
Koda H; Faculty of Medicine, Medicine and Clinical Science, Tottori University, Yonago, Japan.
Yamashita T; Faculty of Medicine, Medicine and Clinical Science, Tottori University, Yonago, Japan.
Onoyama T; Faculty of Medicine, Medicine and Clinical Science, Tottori University, Yonago, Japan.
Kawata S; Faculty of Medicine, Medicine and Clinical Science, Tottori University, Yonago, Japan.
Horie Y; Department of Pathology, Tottori University Hospital, Yonago, Japan.
Isomoto H; Faculty of Medicine, Medicine and Clinical Science, Tottori University, Yonago, Japan.
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Źródło :
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society [Dig Endosc] 2018 Nov; Vol. 30 (6), pp. 771-776. Date of Electronic Publication: 2018 Jul 19.
Typ publikacji :
Journal Article
MeSH Terms :
Hormones*
Secretin*
Synthetic Drugs*
Carcinoma, Pancreatic Ductal/*diagnosis
Pancreatic Juice/*cytology
Pancreatic Neoplasms/*diagnosis
Adult ; Aged ; Aged, 80 and over ; Cytodiagnosis ; Endoscopic Ultrasound-Guided Fine Needle Aspiration ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Sensitivity and Specificity
Czasopismo naukowe

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