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Wyświetlanie 1-14 z 14
Tytuł :
Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist.
Autorzy :
Zhang X; Department of Experimental Medicine , Baruch S. Blumberg Institute , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States.; Artificial Liver Center, Beijing Youan Hospital , Capital Medical University , 8 Xitoutiao , Fengtai, Beijing 100069 , China.
Liu B; Department of Experimental Medicine , Baruch S. Blumberg Institute , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States.; Department of Gastroenterology, Henan Provincial People's Hospital , People's Hospital of Zhengzhou University , 7 Weiwu Road , Jinshui, Zhengzhou , Henan 450016 , China.
Tang L; Microbiology and Immunology Graduate Program , Drexel University College of Medicine , 2900 West Queen Lane , Philadelphia , Pennsylvania 19129 , United States.
Su Q; Department of Experimental Medicine , Baruch S. Blumberg Institute , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States.
Hwang N; Department of Experimental Medicine , Baruch S. Blumberg Institute , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States.
Sehgal M; Department of Experimental Medicine , Baruch S. Blumberg Institute , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States.
Cheng J; Department of Experimental Medicine , Baruch S. Blumberg Institute , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States.
Ma J; Department of Experimental Medicine , Baruch S. Blumberg Institute , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States.
Zhang X; Department of Experimental Medicine , Baruch S. Blumberg Institute , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States.
Tan Y; Genomics Facilities , Fox Chase Cancer Center , 333 Cottman Avenue , Philadelphia , Pennsylvania 19111 , United States.
Zhou Y; Bioinformatics and Biostatistics Facility , Fox Chase Cancer Center , 333 Cottman Avenue , Philadelphia , Pennsylvania 19111 , United States.
Duan Z; Artificial Liver Center, Beijing Youan Hospital , Capital Medical University , 8 Xitoutiao , Fengtai, Beijing 100069 , China.
DeFilippis VR; Vaccine and Gene Therapy Institute , Oregon Health and Science University , 505 Northwest 185th Avenue , Beaverton , Oregon 97006 , United States.
Viswanathan U; Department of Experimental Medicine , Baruch S. Blumberg Institute , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States.
Kulp J; Department of Experimental Medicine , Baruch S. Blumberg Institute , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States.
Du Y; Department of Experimental Medicine , Baruch S. Blumberg Institute , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States.
Guo JT; Department of Experimental Medicine , Baruch S. Blumberg Institute , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States.
Chang J; Department of Experimental Medicine , Baruch S. Blumberg Institute , 3805 Old Easton Road , Doylestown , Pennsylvania 18902 , United States.
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Źródło :
ACS infectious diseases [ACS Infect Dis] 2019 Jul 12; Vol. 5 (7), pp. 1139-1149. Date of Electronic Publication: 2019 May 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*chemical synthesis
Benzodioxoles/*chemical synthesis
Flavivirus Infections/*immunology
Interferons/*metabolism
Membrane Proteins/*agonists
Adaptive Immunity/drug effects ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Benzodioxoles/chemistry ; Benzodioxoles/pharmacology ; Cells, Cultured ; Hep G2 Cells ; High-Throughput Screening Assays ; Humans ; Immunity, Innate/drug effects ; Membrane Proteins/chemistry ; Molecular Structure ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Hepatitis C Virus Infection: Host⁻Virus Interaction and Mechanisms of Viral Persistence.
Autorzy :
Chigbu DI; Department of Microbiology and Immunology, and the Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 2900 West Queen Lane, Philadelphia, PA 19129, USA. .; Pennsylvania College of Optometry at Salus University, Elkins Park, PA 19027, USA. .
Loonawat R; Department of Microbiology and Immunology, and the Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 2900 West Queen Lane, Philadelphia, PA 19129, USA. .
Sehgal M; Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA. .
Patel D; Department of Microbiology and Immunology, and the Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 2900 West Queen Lane, Philadelphia, PA 19129, USA. .
Jain P; Department of Microbiology and Immunology, and the Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 2900 West Queen Lane, Philadelphia, PA 19129, USA. .
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Źródło :
Cells [Cells] 2019 Apr 25; Vol. 8 (4). Date of Electronic Publication: 2019 Apr 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Hepacivirus/*metabolism
Hepatitis C/*immunology
Hepatitis C/*metabolism
Host Microbial Interactions/*physiology
Adaptive Immunity/immunology ; Antiviral Agents/metabolism ; Cytokines/metabolism ; Hepacivirus/genetics ; Hepacivirus/pathogenicity ; Hepatitis C/virology ; Hepatocytes/metabolism ; Humans ; Immunity, Innate/immunology ; Interferons/metabolism ; Killer Cells, Natural/immunology ; Liver Cirrhosis/immunology ; Toll-Like Receptors/metabolism
Czasopismo naukowe
Tytuł :
Unique pattern of neutrophil migration and function during tumor progression.
Autorzy :
Patel S; Immunology, Microenvironment, and Metastasis, Wistar Institute, Philadelphia, PA, USA.; Bristol-Myers Squibb, Lawrenceville, NJ, USA.
Fu S; Immunology, Microenvironment, and Metastasis, Wistar Institute, Philadelphia, PA, USA.; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Mastio J; Immunology, Microenvironment, and Metastasis, Wistar Institute, Philadelphia, PA, USA.
Dominguez GA; Immunology, Microenvironment, and Metastasis, Wistar Institute, Philadelphia, PA, USA.; ITUS Corporation, San Jose, CA, USA.
Purohit A; Immunology, Microenvironment, and Metastasis, Wistar Institute, Philadelphia, PA, USA.
Kossenkov A; Immunology, Microenvironment, and Metastasis, Wistar Institute, Philadelphia, PA, USA.
Lin C; Immunology, Microenvironment, and Metastasis, Wistar Institute, Philadelphia, PA, USA.
Alicea-Torres K; Immunology, Microenvironment, and Metastasis, Wistar Institute, Philadelphia, PA, USA.
Sehgal M; Immunology, Microenvironment, and Metastasis, Wistar Institute, Philadelphia, PA, USA.
Nefedova Y; Immunology, Microenvironment, and Metastasis, Wistar Institute, Philadelphia, PA, USA.
Zhou J; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Languino LR; Sidney Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Clendenin C; University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Vonderheide RH; University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Mulligan C; Helen F Graham Cancer Center at Christiana Care Health System, Wilmington, DE, USA.
Nam B; Helen F Graham Cancer Center at Christiana Care Health System, Wilmington, DE, USA.
Hockstein N; Helen F Graham Cancer Center at Christiana Care Health System, Wilmington, DE, USA.
Masters G; Helen F Graham Cancer Center at Christiana Care Health System, Wilmington, DE, USA.
Guarino M; Helen F Graham Cancer Center at Christiana Care Health System, Wilmington, DE, USA.
Schug ZT; Molecular & Cellular Oncogenesis Programs, Wistar Institute, Philadelphia, PA, USA.
Altieri DC; Immunology, Microenvironment, and Metastasis, Wistar Institute, Philadelphia, PA, USA.
Gabrilovich DI; Immunology, Microenvironment, and Metastasis, Wistar Institute, Philadelphia, PA, USA. .
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Źródło :
Nature immunology [Nat Immunol] 2018 Nov; Vol. 19 (11), pp. 1236-1247. Date of Electronic Publication: 2018 Oct 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Chemotaxis, Leukocyte/*immunology
Neoplasms/*immunology
Neoplasms/*pathology
Neutrophil Infiltration/*immunology
Neutrophils/*immunology
Aged ; Animals ; Disease Progression ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged
Czasopismo naukowe
Tytuł :
Identification of Residues Controlling Restriction versus Enhancing Activities of IFITM Proteins on Entry of Human Coronaviruses.
Autorzy :
Zhao X; Beijing Ditan Hospital, Capital Medical University, Beijing, China .; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, Pennsylvania, USA.
Sehgal M; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, Pennsylvania, USA.
Hou Z; Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Cheng J; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, Pennsylvania, USA.
Shu S; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, Pennsylvania, USA.; Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wu S; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, Pennsylvania, USA.
Guo F; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, Pennsylvania, USA.
Le Marchand SJ; Department of Biology, Drexel University, Philadelphia, Pennsylvania, USA.
Lin H; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.
Chang J; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, Pennsylvania, USA.
Guo JT; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, Pennsylvania, USA .
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Źródło :
Journal of virology [J Virol] 2018 Feb 26; Vol. 92 (6). Date of Electronic Publication: 2018 Feb 26 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation, Missense*
Protein Multimerization*
Virus Internalization*
Antigens, Differentiation/*metabolism
Coronavirus/*metabolism
Membrane Proteins/*metabolism
RNA-Binding Proteins/*metabolism
Amino Acid Motifs ; Amino Acid Substitution ; Antigens, Differentiation/genetics ; Cell Line, Tumor ; Coronavirus/genetics ; Humans ; Membrane Proteins/genetics ; RNA-Binding Proteins/genetics ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism
Czasopismo naukowe
Tytuł :
A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonists.
Autorzy :
Liu B; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, PA, USA; Department of Gastroenterology, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Tang L; Microbiology and Immunology Graduate Program, Drexel University College of Medicine, Philadelphia, PA, USA.
Zhang X; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, PA, USA; Artificial Liver Center, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Ma J; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, PA, USA.
Sehgal M; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, PA, USA.
Cheng J; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, PA, USA.
Zhang X; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, PA, USA.
Zhou Y; Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, PA, USA.
Du Y; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, PA, USA.
Kulp J; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, PA, USA.
Guo JT; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, PA, USA. Electronic address: .
Chang J; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, PA, USA. Electronic address: .
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Źródło :
Antiviral research [Antiviral Res] 2017 Nov; Vol. 147, pp. 37-46. Date of Electronic Publication: 2017 Oct 02.
Typ publikacji :
Journal Article
MeSH Terms :
High-Throughput Screening Assays*
Antiviral Agents/*pharmacology
Drug Discovery/*methods
Immunity, Innate/*drug effects
Interferon Inducers/*pharmacology
Membrane Proteins/*agonists
Nucleotidyltransferases/*antagonists & inhibitors
Piperazines/*pharmacology
Spiro Compounds/*pharmacology
Animals ; Antiviral Agents/chemistry ; Cell Survival/drug effects ; Cells, Cultured ; Flavivirus/drug effects ; Gene Expression/drug effects ; Humans ; Interferon Inducers/chemistry ; Lethal Dose 50 ; Membrane Proteins/genetics ; Mice ; Mutation ; Nucleotidyltransferases/genetics ; Piperazines/chemistry ; Signal Transduction/drug effects ; Species Specificity ; Spiro Compounds/chemistry ; Transcription Factors/genetics ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Activation of Stimulator of Interferon Genes in Hepatocytes Suppresses the Replication of Hepatitis B Virus.
Autorzy :
Guo F; Baruch S. Blumberg Institute, Doylestown, Pennsylvania, USA.
Tang L; Microbiology and Immunology Graduate Program, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Shu S; Baruch S. Blumberg Institute, Doylestown, Pennsylvania, USA.; Department of Pediatrics, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Sehgal M; Baruch S. Blumberg Institute, Doylestown, Pennsylvania, USA.
Sheraz M; Microbiology and Immunology Graduate Program, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Liu B; Baruch S. Blumberg Institute, Doylestown, Pennsylvania, USA.; Department of Gastroenterology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
Zhao Q; Baruch S. Blumberg Institute, Doylestown, Pennsylvania, USA.
Cheng J; Baruch S. Blumberg Institute, Doylestown, Pennsylvania, USA.
Zhao X; Baruch S. Blumberg Institute, Doylestown, Pennsylvania, USA.
Zhou T; Baruch S. Blumberg Institute, Doylestown, Pennsylvania, USA.
Chang J; Baruch S. Blumberg Institute, Doylestown, Pennsylvania, USA .
Guo JT; Baruch S. Blumberg Institute, Doylestown, Pennsylvania, USA .
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Sep 22; Vol. 61 (10). Date of Electronic Publication: 2017 Sep 22 (Print Publication: 2017).
Typ publikacji :
Journal Article
MeSH Terms :
Hepatitis B virus/*growth & development
Hepatocytes/*immunology
Interferons/*biosynthesis
Macrophages/*immunology
Membrane Proteins/*metabolism
Virus Replication/*genetics
Animals ; Antiviral Agents/pharmacology ; Cell Line, Tumor ; Hep G2 Cells ; Hepatitis B virus/immunology ; Hepatitis B, Chronic/drug therapy ; Hepatitis B, Chronic/virology ; Hepatocytes/metabolism ; Hepatocytes/virology ; Humans ; Interferons/immunology ; Macrophages/metabolism ; Macrophages/virology ; Membrane Proteins/agonists ; Mice ; Nucleotidyltransferases/metabolism ; Organic Anion Transporters, Sodium-Dependent/metabolism ; Symporters/metabolism
Czasopismo naukowe
Tytuł :
IFN-α-Induced Downregulation of miR-221 in Dendritic Cells: Implications for HCV Pathogenesis and Treatment.
Autorzy :
Sehgal M; 1 Department of Microbiology and Immunology, Drexel University College of Medicine , Philadelphia, Pennsylvania.
Zeremski M; 2 Weill Cornell Medical College , New York, New York.
Talal AH; 3 School of Medicine and Biomedical Sciences, University at Buffalo , Buffalo, New York.
Ginwala R; 1 Department of Microbiology and Immunology, Drexel University College of Medicine , Philadelphia, Pennsylvania.
Elrod E; 4 Emory Vaccine Center , Atlanta, Georgia .
Grakoui A; 4 Emory Vaccine Center , Atlanta, Georgia .
Li QG; 5 Duke University Medical Center , Durham, North Carolina.
Philip R; 6 Immunotope, Inc., Pennsylvania Biotechnology Center , Doylestown, Pennsylvania.
Khan ZK; 1 Department of Microbiology and Immunology, Drexel University College of Medicine , Philadelphia, Pennsylvania.
Jain P; 1 Department of Microbiology and Immunology, Drexel University College of Medicine , Philadelphia, Pennsylvania.
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Źródło :
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research [J Interferon Cytokine Res] 2015 Sep; Vol. 35 (9), pp. 698-709. Date of Electronic Publication: 2015 Jun 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Dendritic Cells/*metabolism
Dendritic Cells/*virology
Down-Regulation/*genetics
Hepacivirus/*pathogenicity
Interferon-alpha/*metabolism
MicroRNAs/*genetics
Apoptosis/physiology ; HIV Infections/genetics ; HIV Infections/metabolism ; HIV Infections/virology ; HIV-1/pathogenicity ; Hepatitis C/genetics ; Hepatitis C/metabolism ; Hepatitis C/virology ; Hepatocytes/metabolism ; Hepatocytes/virology ; Humans ; Interleukin-6/metabolism ; Janus Kinases/metabolism ; Kupffer Cells/metabolism ; Kupffer Cells/virology ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/virology ; Liver/metabolism ; Liver/virology ; Liver Cirrhosis, Alcoholic/genetics ; Liver Cirrhosis, Alcoholic/metabolism ; Liver Cirrhosis, Alcoholic/virology ; STAT3 Transcription Factor/metabolism ; Suppressor of Cytokine Signaling 1 Protein ; Suppressor of Cytokine Signaling Proteins/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB.
Autorzy :
Jain P
Lavorgna A
Sehgal M
Gao L
Ginwala R
Sagar D
Harhaj EW
Khan ZK
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Źródło :
Retrovirology [Retrovirology] 2015 Feb 27; Vol. 12, pp. 23. Date of Electronic Publication: 2015 Feb 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Transformation, Viral*
Host-Pathogen Interactions*
CD4-Positive T-Lymphocytes/*virology
Cyclic AMP Response Element-Binding Protein/*metabolism
Gene Products, tax/*metabolism
Human T-lymphotropic virus 1/*physiology
CD4-Positive T-Lymphocytes/physiology ; Cells, Cultured ; Humans ; MEF2 Transcription Factors/metabolism ; Promoter Regions, Genetic ; Protein Binding ; Protein Multimerization ; Transcription, Genetic ; Virus Replication
Czasopismo naukowe
Tytuł :
Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2.
Autorzy :
Zhao X; Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, USA Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, Pennsylvania, USA.
Guo F; Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, USA.
Comunale MA; Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, USA.
Mehta A; Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, USA.
Sehgal M; Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, USA.
Jain P; Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, USA.
Cuconati A; Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, Pennsylvania, USA.
Lin H; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.
Block TM; Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, USA Baruch S. Blumberg Institute, Hepatitis B Foundation, Doylestown, Pennsylvania, USA.
Chang J; Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, USA.
Guo JT; Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania, USA .
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 Jan; Vol. 59 (1), pp. 206-16. Date of Electronic Publication: 2014 Oct 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Coronavirus NL63, Human/*pathogenicity
Glucosidases/*antagonists & inhibitors
Peptidyl-Dipeptidase A/*metabolism
SARS Virus/*pathogenicity
Virus Internalization/*drug effects
Angiotensin-Converting Enzyme 2 ; Antiviral Agents/chemistry ; Coronavirus NL63, Human/drug effects ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/metabolism ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/pharmacology ; Host-Pathogen Interactions/drug effects ; Humans ; Imino Sugars/chemistry ; Imino Sugars/pharmacology ; Molecular Targeted Therapy ; Peptidyl-Dipeptidase A/chemistry ; SARS Virus/drug effects ; Spike Glycoprotein, Coronavirus/metabolism
Czasopismo naukowe
Tytuł :
Host Genetic Factors and Dendritic Cell Responses Associated with the Outcome of Interferon/Ribavirin Treatment in HIV-1/HCV Co-Infected Individuals.
Autorzy :
Sehgal M; Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.
Zeremski M; School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Talal AH; School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Khan ZK; Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.
Capocasale R; Flowmetric, Inc., Pennsylvania Biotechnology Center, Doylestown, PA, USA.
Philip R; Immunotope, Inc., Pennsylvania Biotechnology Center, Doylestown, PA, USA.
Jain P; Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.
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Źródło :
Journal of clinical & cellular immunology [J Clin Cell Immunol] 2014 Oct 31; Vol. 5.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain Tax protein.
Autorzy :
Jaworski E; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110.
Narayanan A; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110.
Van Duyne R; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110, the Department of Microbiology, Immunology, and Tropical Medicine and.
Shabbeer-Meyering S; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110.
Iordanskiy S; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110, the Department of Microbiology, Immunology, and Tropical Medicine and.
Saifuddin M; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110.
Das R; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110.
Afonso PV; the Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département de Virologie, Institut Pasteur, F-75015 Paris, France, CNRS, UMR3569, F-75015 Paris, France, and.
Sampey GC; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110.
Chung M; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110.
Popratiloff A; the Department of Chemistry, George Washington University, Washington, D. C. 20037.
Shrestha B; Center for Microscopy and Image Analysis, George Washington University Medical Center, Washington, D. C. 20037.
Sehgal M; the Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Doylestown, Pennsylvania 18902.
Jain P; the Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Doylestown, Pennsylvania 18902.
Vertes A; Center for Microscopy and Image Analysis, George Washington University Medical Center, Washington, D. C. 20037.
Mahieux R; the Equipe Oncogenèse Rétrovirale, Equipe labelisée 'Ligue Nationale Contre le Cancer,' International Center for Research in Infectiology, INSERM U1111-CNRS UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon 1, Lyon 69364 Cedex 07, France.
Kashanchi F; From the School of Systems Biology, National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia 20110, .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2014 Aug 08; Vol. 289 (32), pp. 22284-305. Date of Electronic Publication: 2014 Jun 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Products, tax/*metabolism
Human T-lymphotropic virus 1/*pathogenicity
Human T-lymphotropic virus 1/*physiology
Cell Line ; Cell Survival ; Dendritic Cells/immunology ; Dendritic Cells/physiology ; Dendritic Cells/virology ; Exosomes/metabolism ; Exosomes/virology ; Gene Products, tax/immunology ; HTLV-I Infections/etiology ; HTLV-I Infections/physiopathology ; HTLV-I Infections/virology ; Host-Pathogen Interactions ; Human T-lymphotropic virus 1/immunology ; Humans ; Virulence ; fas Receptor/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Lack of recall response to Tax in ATL and HAM/TSP patients but not in asymptomatic carriers of human T-cell leukemia virus type 1.
Autorzy :
Manuel SL; Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, 19104, USA.
Sehgal M
Connolly J
Makedonas G
Khan ZK
Gardner J
Betts MR
Jain P
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Źródło :
Journal of clinical immunology [J Clin Immunol] 2013 Oct; Vol. 33 (7), pp. 1223-39. Date of Electronic Publication: 2013 Jul 26.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Human T-lymphotropic virus 1/*immunology
Leukemia-Lymphoma, Adult T-Cell/*immunology
Paraparesis, Tropical Spastic/*immunology
Programmed Cell Death 1 Receptor/*metabolism
Adolescent ; Adult ; Aged ; Asymptomatic Diseases ; CD8-Positive T-Lymphocytes/virology ; Chemokine CCL3/genetics ; Chemokine CCL3/metabolism ; Cytokines/genetics ; Cytokines/metabolism ; Cytotoxicity, Immunologic ; Female ; Gene Expression Regulation ; Gene Products, tax/immunology ; Human T-lymphotropic virus 1/growth & development ; Humans ; Lymphocyte Activation ; Lymphocyte Count ; Middle Aged ; Programmed Cell Death 1 Receptor/genetics ; Transcriptome ; Viral Load ; Young Adult
Czasopismo naukowe
Tytuł :
An altered maturation and adhesion phenotype of dendritic cells in diseased individuals compared to asymptomatic carriers of human T cell leukemia virus type 1.
Autorzy :
Manuel SL; Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Sehgal M
Khan ZK
Goedert JJ
Betts MR
Jain P
Pokaż więcej
Źródło :
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2013 Sep; Vol. 29 (9), pp. 1273-85. Date of Electronic Publication: 2013 Jul 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Carrier State/*virology
Cell Adhesion/*genetics
Dendritic Cells/*immunology
Human T-lymphotropic virus 1/*immunology
Paraparesis, Tropical Spastic/*genetics
Adult ; Antibodies, Viral ; B7-2 Antigen/immunology ; B7-2 Antigen/metabolism ; B7-H1 Antigen/immunology ; B7-H1 Antigen/metabolism ; Biomarkers ; Cohort Studies ; Female ; Fluorescent Antibody Technique ; HLA-A Antigens/immunology ; HLA-A Antigens/metabolism ; HLA-B Antigens/immunology ; HLA-B Antigens/metabolism ; HLA-C Antigens/immunology ; HLA-C Antigens/metabolism ; HLA-DR Antigens/immunology ; HLA-DR Antigens/metabolism ; Human T-lymphotropic virus 1/genetics ; Humans ; Male ; Middle Aged ; Paraparesis, Tropical Spastic/immunology ; Paraparesis, Tropical Spastic/virology
Czasopismo naukowe
Tytuł :
Dendritic Cells in HIV-1 and HCV Infection: Can They Help Win the Battle?
Autorzy :
Sehgal M; Department of Microbiology and Immunology, and the Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Khan ZK; Department of Microbiology and Immunology, and the Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Talal AH; Center for the Study of Hepatitis C, Weill Cornell Medical College, New York, NY.
Jain P; Department of Microbiology and Immunology, and the Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
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Źródło :
Virology : research and treatment [Virology (Auckl)] 2013 Feb 11; Vol. 4, pp. 1-25. Date of Electronic Publication: 2013 Feb 11 (Print Publication: 2013).
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
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