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Wyświetlanie 1-5 z 5
Tytuł :
CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions
Autorzy :
Johannes Jung
Sonja C. Buisman
Ellen Weersing
Albertina Dethmers-Ausema
Erik Zwart
Hein Schepers
Mike R. Dekker
Seka S. Lazare
Franziska Hammerl
Yulia Skokova
Susanne M. Kooistra
Karin Klauke
Raymond A. Poot
Leonid V. Bystrykh
Gerald de Haan
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Temat :
Biology (General)
QH301-705.5
Źródło :
Cell Reports, Vol 26, Iss 7, Pp 1906-1918.e8 (2019)
Opis pliku :
electronic resource
Relacje :
http://www.sciencedirect.com/science/article/pii/S2211124719300683; https://doaj.org/toc/2211-1247
Dostęp URL :
https://doaj.org/article/8e9f30d38fc142b58e0349be1f6e3dd2
Czasopismo naukowe
Tytuł :
A comprehensive transcriptome signature of murine hematopoietic stem cell aging.
Autorzy :
Flohr Svendsen A; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and.
Yang D; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and.
Kim K; Transcriptional Control of Tissue Homeostasis Laboratory, Leibniz Institute on Aging, Fritz Lipmann Institute e.V., Jena, Germany.
Lazare S; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and.
Skinder N; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and.
Zwart E; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and.
Mura-Meszaros A; Transcriptional Control of Tissue Homeostasis Laboratory, Leibniz Institute on Aging, Fritz Lipmann Institute e.V., Jena, Germany.
Ausema A; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and.
von Eyss B; Transcriptional Control of Tissue Homeostasis Laboratory, Leibniz Institute on Aging, Fritz Lipmann Institute e.V., Jena, Germany.
de Haan G; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and.
Bystrykh L; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and.
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Źródło :
Blood [Blood] 2021 Aug 12; Vol. 138 (6), pp. 439-451.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1.
Autorzy :
Renders S; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120, Heidelberg, Germany.; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.
Svendsen AF; Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Panten J; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
Rama N; Apoptosis, Cancer and Development Laboratory, Equipe labellisée 'La Ligue,' LabEx DEVweCAN, Institut Convergence Rabelais, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon1, Centre Léon Bérard, 69008, Lyon, France.
Maryanovich M; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Sommerkamp P; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
Ladel L; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120, Heidelberg, Germany.
Redavid AR; Apoptosis, Cancer and Development Laboratory, Equipe labellisée 'La Ligue,' LabEx DEVweCAN, Institut Convergence Rabelais, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon1, Centre Léon Bérard, 69008, Lyon, France.
Gibert B; Apoptosis, Cancer and Development Laboratory, Equipe labellisée 'La Ligue,' LabEx DEVweCAN, Institut Convergence Rabelais, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon1, Centre Léon Bérard, 69008, Lyon, France.
Lazare S; Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Ducarouge B; Apoptosis, Cancer and Development Laboratory, Equipe labellisée 'La Ligue,' LabEx DEVweCAN, Institut Convergence Rabelais, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon1, Centre Léon Bérard, 69008, Lyon, France.
Schönberger K; Max Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg, Germany.
Narr A; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
Tourbez M; Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Dethmers-Ausema B; Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Zwart E; Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Hotz-Wagenblatt A; Core Facility Omics IT and Data Management, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Zhang D; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Korn C; Wellcome Trust/MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0AH, UK.; Department of Haematology, University of Cambridge, Cambridge, CB2 0AH, UK.; NHS Blood and Transplant, Cambridge, CB2 0PT, UK.
Zeisberger P; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120, Heidelberg, Germany.
Przybylla A; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120, Heidelberg, Germany.
Sohn M; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120, Heidelberg, Germany.
Mendez-Ferrer S; Wellcome Trust/MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0AH, UK.; Department of Haematology, University of Cambridge, Cambridge, CB2 0AH, UK.; NHS Blood and Transplant, Cambridge, CB2 0PT, UK.
Heikenwälder M; Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany.
Brune M; Department of Internal Medicine I and Clinical Chemistry, Heidelberg University Hospital, Heidelberg, Germany.
Klimmeck D; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120, Heidelberg, Germany.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120, Heidelberg, Germany.
Bystrykh L; Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Frenette PS; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Mehlen P; Apoptosis, Cancer and Development Laboratory, Equipe labellisée 'La Ligue,' LabEx DEVweCAN, Institut Convergence Rabelais, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon1, Centre Léon Bérard, 69008, Lyon, France.
de Haan G; Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Cabezas-Wallscheid N; Max Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg, Germany. .
Trumpp A; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120, Heidelberg, Germany. .; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120, Heidelberg, Germany. .; German Cancer Consortium (DKTK), 69120, Heidelberg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 27; Vol. 12 (1), pp. 608. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Stem Cell Niche*
Hematopoietic Stem Cells/*metabolism
Membrane Proteins/*metabolism
Netrin-1/*metabolism
Animals ; Arterioles/metabolism ; Cell Differentiation ; Cell Proliferation ; Cellular Senescence ; Gene Deletion ; Hematopoietic Stem Cell Transplantation ; Mice, Mutant Strains ; Mice, Transgenic ; Signal Transduction
Czasopismo naukowe
Tytuł :
Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions.
Autorzy :
Martín-Pardillos A; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Tsaalbi-Shtylik A; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Chen S; Department of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands.
Lazare S; European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
van Os RP; European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Dethmers-Ausema A; European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Fakouri NB; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Bosshard M; Department of Molecular Mechanisms of Disease, University of Zürich, Zürich, Switzerland.
Aprigliano R; Department of Molecular Mechanisms of Disease, University of Zürich, Zürich, Switzerland.; Department of Cancer Research and Molecular Medicine, Norwegian University for Science and Technology, Trondheim, Norway.
van Loon B; Department of Molecular Mechanisms of Disease, University of Zürich, Zürich, Switzerland.; Department of Cancer Research and Molecular Medicine, Norwegian University for Science and Technology, Trondheim, Norway.
Salvatori DCF; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands; and.
Hashimoto K; Department of Pharmacological Sciences, Stony Brook University Medical School, Stony Brook, NY.
Dingemanse-van der Spek C; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Moriya M; Department of Pharmacological Sciences, Stony Brook University Medical School, Stony Brook, NY.
Rasmussen LJ; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
de Haan G; European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Raaijmakers MHGP; Department of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands.
de Wind N; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
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Źródło :
Blood [Blood] 2017 Sep 28; Vol. 130 (13), pp. 1523-1534. Date of Electronic Publication: 2017 Aug 21.
Typ publikacji :
Journal Article
MeSH Terms :
Oxidative Stress*
DNA Damage/*genetics
DNA Repair/*genetics
Hematopoietic System/*physiology
Animals ; Apoptosis ; Bone Marrow/pathology ; Cell Proliferation ; Cellular Senescence/genetics ; DNA-Directed DNA Polymerase ; Genome ; Hematopoietic Stem Cells/pathology ; Mice ; Nucleotidyltransferases
Czasopismo naukowe
Tytuł :
Lifelong dietary intervention does not affect hematopoietic stem cell function.
Autorzy :
Lazare S; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen Antonius Deusinglaan 1, Groningen, The Netherlands.
Ausema A; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen Antonius Deusinglaan 1, Groningen, The Netherlands.
Reijne AC; Laboratory of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, Groningen, The Netherlands; Systems Biology Centre for Energy Metabolism and Ageing, University of Groningen, Groningen, The Netherlands; Groningen Institute for Evolutionary Life Sciences (GELIFES), Department of Behavioral Neuroscience, University of Groningen, Groningen, The Netherlands.
van Dijk G; Systems Biology Centre for Energy Metabolism and Ageing, University of Groningen, Groningen, The Netherlands; Groningen Institute for Evolutionary Life Sciences (GELIFES), Department of Behavioral Neuroscience, University of Groningen, Groningen, The Netherlands; Centre for Isotope Research, University of Groningen, Groningen, The Netherlands.
van Os R; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen Antonius Deusinglaan 1, Groningen, The Netherlands; Mouse Clinic for Cancer and Aging, University Medical Center Groningen, University of Groningen Antonius Deusinglaan 1, Groningen, The Netherlands.
de Haan G; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen Antonius Deusinglaan 1, Groningen, The Netherlands; Mouse Clinic for Cancer and Aging, University Medical Center Groningen, University of Groningen Antonius Deusinglaan 1, Groningen, The Netherlands. Electronic address: .
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Źródło :
Experimental hematology [Exp Hematol] 2017 Sep; Vol. 53, pp. 26-30. Date of Electronic Publication: 2017 Jun 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diet*
Hematopoietic Stem Cells/*physiology
Aging ; Animals ; Caloric Restriction ; Diet, High-Fat ; Humans ; Mice
Czasopismo naukowe
    Wyświetlanie 1-5 z 5

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