Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Senescence"" wg kryterium: Temat


Starter badań:

Tytuł :
Identification and functional analysis of senescence-associated secretory phenotype of premature senescent hepatocytes induced by hexavalent chromium.
Autorzy :
Ma Y; Department of Health Toxicology, Xiangya School of Public Health, Central South University, Changsha 410078, PR China.
Liang Y; Department of Health Toxicology, Xiangya School of Public Health, Central South University, Changsha 410078, PR China.
Liang N; Department of Health Toxicology, Xiangya School of Public Health, Central South University, Changsha 410078, PR China.
Zhang Y; Department of Health Toxicology, Xiangya School of Public Health, Central South University, Changsha 410078, PR China.
Xiao F; Department of Health Toxicology, Xiangya School of Public Health, Central South University, Changsha 410078, PR China. Electronic address: .
Pokaż więcej
Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Mar 15; Vol. 211, pp. 111908. Date of Electronic Publication: 2021 Jan 10.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*
Chromium/*toxicity
Cell Line ; Chromatography, Liquid ; Hepatocytes/metabolism ; Humans ; Microfilament Proteins/metabolism ; Phenotype ; Signal Transduction ; Tandem Mass Spectrometry ; Up-Regulation
Czasopismo naukowe
Tytuł :
The aging lung: Physiology, disease, and immunity.
Autorzy :
Schneider JL; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Dana Farber Cancer Institute, Boston, MA 02115, USA; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
Rowe JH; Division of Hematology Boston Children's Hospital and Division of Pediatric Oncology Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Garcia-de-Alba C; Stem Cell Program and Divisions of Hematology/Oncology and Pulmonary Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Kim CF; Stem Cell Program and Divisions of Hematology/Oncology and Pulmonary Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: .
Sharpe AH; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Disease, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: .
Haigis MC; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: .
Pokaż więcej
Źródło :
Cell [Cell] 2021 Apr 15; Vol. 184 (8), pp. 1990-2019. Date of Electronic Publication: 2021 Apr 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Aging*/immunology
Aging*/pathology
Cellular Senescence*
Lung*/immunology
Lung*/pathology
Lung Diseases*/immunology
Lung Diseases*/pathology
Adaptive Immunity ; Aged ; COVID-19/immunology ; COVID-19/pathology ; Humans ; Oxidative Stress
Czasopismo naukowe
Tytuł :
Senescence under appraisal: hopes and challenges revisited.
Autorzy :
Davan-Wetton CSA; The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Pessolano E; The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.; Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084, Fisciano, Italy.
Perretti M; The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.; Centre for Inflammation and Therapeutic Innovation, Queen Mary University of London, London, EC1M 6BQ, UK.
Montero-Melendez T; The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK. .; Centre for Inflammation and Therapeutic Innovation, Queen Mary University of London, London, EC1M 6BQ, UK. .
Pokaż więcej
Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Apr; Vol. 78 (7), pp. 3333-3354. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Aging*
Cellular Senescence*
Immune System*
Wound Healing*
Fibrosis/*pathology
Neoplasms/*pathology
Animals ; Cell Proliferation ; Humans ; Translational Medical Research
Czasopismo naukowe
Tytuł :
Extracts of Jasminum sambac flowers fermented by Lactobacillus rhamnosus inhibit H 2 O 2 - and UVB-induced aging in human dermal fibroblasts.
Autorzy :
Ho CC; Department of Biological Science and Technology, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.
Ng SC; Department of Biological Science and Technology, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.
Chuang HL; Department of Biological Science and Technology, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.
Wen SY; Department of Dermatology, Taipei City Hospital, Renai Branch, Taipei, Taiwan.; Department of Cosmetic Applications and Management, Mackay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan.; Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei City, Taiwan.
Kuo CH; Department of Sports Sciences, University of Taipei, Taipei, Taiwan.
Mahalakshmi B; Institute of Research and Development, Duy Tan University, Da Nang, Vietnam.
Huang CY; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.; Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien, Taiwan.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Department of Biotechnology, Asia University, Taichung, Taiwan.
Kuo WW; Department of Biological Science and Technology, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.
Pokaż więcej
Źródło :
Environmental toxicology [Environ Toxicol] 2021 Apr; Vol. 36 (4), pp. 607-619. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*/drug effects
Cellular Senescence*/radiation effects
Antioxidants/*pharmacology
Fibroblasts/*drug effects
Jasminum/*chemistry
Lactobacillus rhamnosus/*metabolism
Plant Extracts/*pharmacology
Antioxidants/isolation & purification ; Antioxidants/metabolism ; Cell Line ; Fermentation ; Fibroblasts/metabolism ; Fibroblasts/radiation effects ; Flowers/chemistry ; Humans ; Hydrogen Peroxide/toxicity ; Plant Extracts/isolation & purification ; Plant Extracts/metabolism ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Skin Aging/drug effects ; Skin Aging/radiation effects ; Ultraviolet Rays
Czasopismo naukowe
Tytuł :
Stiffness and Aging in Cardiovascular Diseases: The Dangerous Relationship between Force and Senescence.
Autorzy :
Ferrari S; Unità di Ingegneria Tissutale Cardiovascolare, Centro cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS), 20138 Milan, Italy.; PhD Program in Translational Medicine, Department of Molecular Medicine, Università degli studi di Pavia, 27100 Pavia, Italy.
Pesce M; Unità di Ingegneria Tissutale Cardiovascolare, Centro cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS), 20138 Milan, Italy.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 26; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cellular Senescence*
Vascular Stiffness*
Cardiovascular Diseases/*metabolism
Animals ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/pathology ; Chromatin Assembly and Disassembly ; Cytoskeleton/metabolism ; Humans ; Mechanotransduction, Cellular
Czasopismo naukowe
Tytuł :
Different Stages of Quiescence, Senescence, and Cell Stress Identified by Molecular Algorithm Based on the Expression of Ki67, RPS6, and Beta-Galactosidase Activity.
Autorzy :
Alessio N; Department of Experimental Medicine, Luigi Vanvitelli Campania University, 80138 Naples, Italy.
Aprile D; Department of Experimental Medicine, Luigi Vanvitelli Campania University, 80138 Naples, Italy.
Cappabianca S; Department of Precision Medicine, Luigi Vanvitelli Campania University, 80138 Naples, Italy.
Peluso G; Research Institute on Ecosystems (IRET), CNR, 80131 Naples, Italy.
Di Bernardo G; Department of Experimental Medicine, Luigi Vanvitelli Campania University, 80138 Naples, Italy.; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, PA 19122, USA.
Galderisi U; Department of Experimental Medicine, Luigi Vanvitelli Campania University, 80138 Naples, Italy.; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, PA 19122, USA.; Genome and Stem Cell Center (GENKOK), Erciyes University, Kayseri 38280, Turkey.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 18; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 18.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Cycle*
Cellular Senescence*
Stress, Physiological*
Ki-67 Antigen/*metabolism
Ribosomal Protein S6/*metabolism
beta-Galactosidase/*metabolism
Humans ; Models, Biological ; Phenotype
Czasopismo naukowe
Tytuł :
Clock knockdown attenuated reactive oxygen species-mediated senescence of chondrocytes through restoring autophagic flux.
Autorzy :
Zhong J; Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China.
Wang B; Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China.
Wu B; Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China.
Shang J; Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China.
Jiang N; Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China.
Cui A; Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China.
Chen Y; Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China.
Xu X; Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China. Electronic address: .
Lu H; Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China. Electronic address: .
Pokaż więcej
Źródło :
Life sciences [Life Sci] 2021 Mar 15; Vol. 269, pp. 119036. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*
Cellular Senescence*
Arthritis, Experimental/*pathology
CLOCK Proteins/*antagonists & inhibitors
Chondrocytes/*pathology
Osteoarthritis/*pathology
Reactive Oxygen Species/*metabolism
Animals ; Apoptosis ; Arthritis, Experimental/metabolism ; CLOCK Proteins/metabolism ; Cartilage, Articular/metabolism ; Cartilage, Articular/pathology ; Cell Cycle ; Cell Movement ; Cell Proliferation ; Cells, Cultured ; Chondrocytes/metabolism ; Circadian Clocks ; Disease Models, Animal ; Homeostasis ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Osteoarthritis/metabolism
Czasopismo naukowe
Tytuł :
Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis.
Autorzy :
Yao C; Women's Guild Lung Institute, Department of Medicine.; The Board of Governors Regenerative Medicine Institute, Department of Biomedical Sciences, and.
Guan X; Women's Guild Lung Institute, Department of Medicine.
Carraro G; Women's Guild Lung Institute, Department of Medicine.
Parimon T; Women's Guild Lung Institute, Department of Medicine.
Liu X; Women's Guild Lung Institute, Department of Medicine.
Huang G; Women's Guild Lung Institute, Department of Medicine.
Mulay A; Women's Guild Lung Institute, Department of Medicine.
Soukiasian HJ; Division of Thoracic Surgery, Cedars-Sinai Medical Center, Los Angeles, California.
David G; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York University, New York, New York; and.
Weigt SS; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California.
Belperio JA; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California.
Chen P; Women's Guild Lung Institute, Department of Medicine.
Jiang D; Women's Guild Lung Institute, Department of Medicine.
Noble PW; Women's Guild Lung Institute, Department of Medicine.
Stripp BR; Women's Guild Lung Institute, Department of Medicine.; The Board of Governors Regenerative Medicine Institute, Department of Biomedical Sciences, and.
Pokaż więcej
Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2021 Mar 15; Vol. 203 (6), pp. 707-717.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
Aging/*pathology
Alveolar Epithelial Cells/*pathology
Idiopathic Pulmonary Fibrosis/*pathology
Aged ; Aged, 80 and over ; Female ; Humans ; Male
Czasopismo naukowe
Tytuł :
Senescence and autophagy in usual interstitial pneumonia of different etiology.
Autorzy :
Gallob F; Diagnostic and Research Institute of Pathology, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010, Graz, Austria.
Brcic L; Diagnostic and Research Institute of Pathology, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010, Graz, Austria.
Eidenhammer S; Diagnostic and Research Institute of Pathology, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010, Graz, Austria.
Rumpp F; Pulmonology Department, Clinics Munich-Bogenhausen, Munich, Germany.
Nerlich A; Pathology Department, Clinics Munich-Bogenhausen, Munich, Germany.
Popper H; Diagnostic and Research Institute of Pathology, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010, Graz, Austria. .
Pokaż więcej
Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 Mar; Vol. 478 (3), pp. 497-506. Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Autophagy*
Cellular Senescence*
Autoimmune Diseases/*pathology
Idiopathic Pulmonary Fibrosis/*pathology
Lung/*pathology
Aged ; Aged, 80 and over ; Autoimmune Diseases/etiology ; Autoimmune Diseases/metabolism ; Autophagy-Related Proteins/analysis ; Biomarkers/analysis ; Cell Cycle Proteins/analysis ; Cell Hypoxia ; Cell Proliferation ; Energy Metabolism ; Epithelial Cells/chemistry ; Epithelial Cells/pathology ; Female ; Glucose Transporter Type 1/analysis ; Humans ; Idiopathic Pulmonary Fibrosis/etiology ; Idiopathic Pulmonary Fibrosis/metabolism ; Immunohistochemistry ; L-Lactate Dehydrogenase/analysis ; Lung/chemistry ; Male ; Middle Aged ; Myofibroblasts/chemistry ; Myofibroblasts/pathology ; Phagocytosis
Czasopismo naukowe
Tytuł :
Identification of GL-V9 as a novel senolytic agent against senescent breast cancer cells.
Autorzy :
Yang D; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, Department of Physiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, People's Republic of China.
Tian X; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, Department of Physiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, People's Republic of China.
Ye Y; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, Department of Physiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, People's Republic of China.
Liang Y; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, Department of Physiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, People's Republic of China.
Zhao J; Pharmaceutical Animal Experimental Center, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, People's Republic of China.
Wu T; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, Department of Physiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, People's Republic of China. Electronic address: .
Lu N; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, Department of Physiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, People's Republic of China. Electronic address: .
Pokaż więcej
Źródło :
Life sciences [Life Sci] 2021 May 01; Vol. 272, pp. 119196. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*metabolism
Cellular Senescence/*drug effects
Flavonoids/*pharmacology
Aging/physiology ; Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Cellular Senescence/physiology ; China ; Female ; Flavonoids/metabolism ; Humans ; Mice ; Mice, Transgenic ; Mitochondria/drug effects ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/prevention & control ; Reactive Oxygen Species/pharmacology ; Signal Transduction/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Feed-forward regulation between cellular senescence and immunosuppression promotes the aging process and age-related diseases.
Autorzy :
Salminen A; Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland. Electronic address: .
Pokaż więcej
Źródło :
Ageing research reviews [Ageing Res Rev] 2021 May; Vol. 67, pp. 101280. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
CD8-Positive T-Lymphocytes*
Cellular Senescence*
Immunosuppression ; Macrophages
Czasopismo naukowe
Tytuł :
Multiple functions of p21 in cancer radiotherapy.
Autorzy :
Kuang Y; Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou, 730000, Gansu, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou, 730000, China.; Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou, 730000, Gansu, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Kang J; College of Energy and Power Engineering, Lanzhou University of Technology, Lanzhou, 730050, China.
Li H; School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, 730050, China.
Liu B; Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou, 730000, Gansu, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou, 730000, China.; Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou, 730000, Gansu, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Zhao X; The First Hospital of Lanzhou University, Lanzhou, 730000, China.
Li L; Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou, 730000, Gansu, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou, 730000, China.; Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou, 730000, Gansu, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Jin X; Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou, 730000, Gansu, China. .; Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou, 730000, China. .; Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou, 730000, Gansu, China. .; University of Chinese Academy of Sciences, Beijing, 100049, China. .
Li Q; Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou, 730000, Gansu, China. .; Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou, 730000, China. .; Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou, 730000, Gansu, China. .; University of Chinese Academy of Sciences, Beijing, 100049, China. .
Pokaż więcej
Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Apr; Vol. 147 (4), pp. 987-1006. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cellular Senescence*
Radiation, Ionizing*
Cyclin-Dependent Kinase Inhibitor p21/*metabolism
Neoplasms/*radiotherapy
Animals ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Humans ; Neoplasms/genetics ; Neoplasms/pathology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis.
Autorzy :
Liu X; Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Chai Y; Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Liu G; Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Su W; Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Guo Q; Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lv X; Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gao P; Johns Hopkins Asthma & Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yu B; Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Ferbeyre G; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC, Canada.
Cao X; Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wan M; Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 Mar 23; Vol. 12 (1), pp. 1832. Date of Electronic Publication: 2021 Mar 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cellular Senescence/*drug effects
Endothelial Cells/*metabolism
Glucocorticoids/*pharmacology
Neovascularization, Physiologic/*drug effects
Nerve Tissue Proteins/*metabolism
Osteoclasts/*metabolism
Ribonuclease, Pancreatic/*metabolism
Animals ; Apoptosis/drug effects ; Bone Development/drug effects ; Cell Proliferation/drug effects ; Cellular Senescence/genetics ; Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Methylprednisolone/pharmacology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Neovascularization, Pathologic ; Nerve Tissue Proteins/genetics ; Osteoclasts/drug effects ; Osteoclasts/enzymology ; Osteogenesis/drug effects ; RNA, Ribosomal/biosynthesis ; RNA, Small Interfering ; Recombinant Proteins ; Ribonuclease, Pancreatic/genetics ; Ribonuclease, Pancreatic/pharmacology ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Tomography Scanners, X-Ray Computed
Czasopismo naukowe
Tytuł :
Senescent cells as promising targets to tackle age-related diseases.
Autorzy :
Prašnikar E; National Institute of Chemistry, Hajdrihova ulica 19, Ljubljana, Slovenia; Graduate School of Biomedicine, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, Ljubljana, Slovenia.
Borišek J; National Institute of Chemistry, Hajdrihova ulica 19, Ljubljana, Slovenia. Electronic address: .
Perdih A; National Institute of Chemistry, Hajdrihova ulica 19, Ljubljana, Slovenia. Electronic address: .
Pokaż więcej
Źródło :
Ageing research reviews [Ageing Res Rev] 2021 Mar; Vol. 66, pp. 101251. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cellular Senescence*
DNA Damage*
Biomarkers ; Immune System
Czasopismo naukowe
Tytuł :
Increased expression of hras induces early, but not full, senescence in the immortal fish cell line, EPC.
Autorzy :
Futami K; Department of Marine Biosciences, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato, Tokyo 108-8477, Japan. Electronic address: .
Aoyama K; Department of Marine Biosciences, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato, Tokyo 108-8477, Japan.
Fukuda K; Department of Marine Biosciences, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato, Tokyo 108-8477, Japan.
Maita M; Department of Marine Biosciences, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato, Tokyo 108-8477, Japan.
Katagiri T; Department of Marine Biosciences, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato, Tokyo 108-8477, Japan.
Pokaż więcej
Źródło :
Gene [Gene] 2021 Jan 10; Vol. 765, pp. 145116. Date of Electronic Publication: 2020 Sep 04.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence/*genetics
Genes, ras/*genetics
Genes, ras/*physiology
Aging/genetics ; Aging/metabolism ; Animals ; Cell Line ; Cells, Cultured ; Cellular Senescence/physiology ; Fishes/genetics ; Humans ; Proto-Oncogene Proteins p21(ras)/genetics
Czasopismo naukowe
Tytuł :
Mitochondrial Glutamine Metabolism Determines Senescence Induction After Chemotherapy.
Autorzy :
Kim B; Department of Biochemistry, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, Republic of Korea.; Institute for Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Gwak J; Department of Biochemistry, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, Republic of Korea.; Institute for Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Lee EK; Department of Biochemistry, The Catholic University of Korea, Seoul, Republic of Korea.; Institute for Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Jeong SM; Department of Biochemistry, The Catholic University of Korea, Seoul, Republic of Korea .; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, Republic of Korea .; Institute for Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea .
Pokaż więcej
Źródło :
Anticancer research [Anticancer Res] 2020 Dec; Vol. 40 (12), pp. 6891-6897.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*/drug effects
Cellular Senescence*/genetics
Antineoplastic Agents/*pharmacology
Glutamine/*metabolism
Mitochondria/*drug effects
Mitochondria/*metabolism
Antineoplastic Agents/therapeutic use ; Biomarkers ; Cell Line, Tumor ; DNA Damage ; Dose-Response Relationship, Drug ; Humans ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
The Multifaceted Role of Plasminogen in Cancer.
Autorzy :
Heissig B; Immunological Diagnosis, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan.
Salama Y; An-Najah Center for Cancer and Stem Cell Research, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus P.O. Box 7, Palestine.
Osada T; Department of Gastroenterology Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu-shi, Chiba 279-0021, Japan.
Okumura K; Immunological Diagnosis, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan.
Hattori K; Center for Genomic & Regenerative Medicine, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 25; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Autophagy*
Cellular Senescence*
Drug Resistance, Neoplasm*/genetics
Anoikis/*genetics
Neoplasms/*metabolism
Plasminogen/*metabolism
Plasminogen Inactivators/*metabolism
Cell Survival ; Exosomes/metabolism ; Extracellular Matrix/metabolism ; Humans ; Neoplasm Metastasis/drug therapy ; Neoplasm Metastasis/genetics ; Neoplasms/drug therapy ; Neoplasms/pathology ; Plasminogen/antagonists & inhibitors ; Plasminogen Inactivators/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Selective Cardiomyocyte Oxidative Stress Leads to Bystander Senescence of Cardiac Stromal Cells.
Autorzy :
Martini H; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.; Institute Cardiomet, FHU IMPACT, University Hospital of Toulouse, 31400 Toulouse, France.
Lefevre L; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.
Sayir S; Institute Cardiomet, FHU IMPACT, University Hospital of Toulouse, 31400 Toulouse, France.
Itier R; Institute Cardiomet, FHU IMPACT, University Hospital of Toulouse, 31400 Toulouse, France.
Maggiorani D; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.
Dutaur M; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.
Marsal DJ; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.
Roncalli J; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.; Institute Cardiomet, FHU IMPACT, University Hospital of Toulouse, 31400 Toulouse, France.
Pizzinat N; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.
Cussac D; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.
Parini A; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.; Institute Cardiomet, FHU IMPACT, University Hospital of Toulouse, 31400 Toulouse, France.
Mialet-Perez J; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.
Douin-Echinard V; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 24; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article
MeSH Terms :
Bystander Effect*
Cellular Senescence*
Oxidative Stress*
Aging/*pathology
Monoamine Oxidase/*physiology
Myocytes, Cardiac/*pathology
Stromal Cells/*pathology
Aging/metabolism ; Animals ; Cells, Cultured ; DNA Damage ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Myocytes, Cardiac/metabolism ; Stromal Cells/metabolism
Czasopismo naukowe
Tytuł :
An Intermediate Concentration of Calcium with Antioxidant Supplement in Culture Medium Enhances Proliferation and Decreases the Aging of Bone Marrow Mesenchymal Stem Cells.
Autorzy :
Yang CD; Graduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 912301, Taiwan.
Chuang SC; Orthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Regeneration Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Musculoskeletal Regeneration Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
Cheng TL; Orthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Regeneration Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Musculoskeletal Regeneration Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
Lee MJ; Department of Bioscience Technology, Chang Jung Christian University, Tainan 71101, Taiwan.; Innovative Research Center of Medicine, Chang Jung Christian University, Tainan 71101, Taiwan.
Chen HT; Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 11221, Taiwan.; Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
Lin SY; Orthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Regeneration Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Musculoskeletal Regeneration Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Departments of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80145, Taiwan.; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
Huang HT; Orthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Regeneration Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Musculoskeletal Regeneration Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Departments of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80145, Taiwan.
Ho CJ; Orthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Regeneration Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Musculoskeletal Regeneration Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Departments of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80145, Taiwan.; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
Lin YS; Orthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Regeneration Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
Kang L; Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Ho ML; Orthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Regeneration Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Musculoskeletal Regeneration Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
Chang JK; Orthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Regeneration Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Musculoskeletal Regeneration Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Departments of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80145, Taiwan.
Chen CH; Orthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Regeneration Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Musculoskeletal Regeneration Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Departments of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.; Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80145, Taiwan.; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80420, Taiwan.; Department of Healthcare Administration and Medical Informatics, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 20; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 20.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*/drug effects
Antioxidants/*pharmacology
Calcium/*pharmacology
Culture Media/*chemistry
Mesenchymal Stem Cells/*cytology
Antigens, CD/metabolism ; Biomarkers/metabolism ; Cell Differentiation/drug effects ; Cell Lineage/drug effects ; Cell Proliferation/drug effects ; Cell Separation ; Cell Shape/drug effects ; Cells, Cultured ; DNA Damage ; Humans ; Mesenchymal Stem Cells/drug effects ; Mesenchymal Stem Cells/metabolism ; Osteoblasts/cytology ; Osteoblasts/drug effects ; Osteoblasts/metabolism ; Telomerase/metabolism ; Telomere Homeostasis ; Tumor Suppressor p53-Binding Protein 1/metabolism
Czasopismo naukowe
Tytuł :
"Empowering" Cardiac Cells via Stem Cell Derived Mitochondrial Transplantation- Does Age Matter?
Autorzy :
Mietsch M; Laboratory Animal Science Unit, Leibniz-Institut für Primatenforschung, Deutsches Primatenzentrum GmbH, Kellnerweg 4, 37077 Göttingen, Germany.; DZHK (German Center for Cardiovascular Research), partner site Göttingen, 37077 Göttingen, Germany.
Hinkel R; Laboratory Animal Science Unit, Leibniz-Institut für Primatenforschung, Deutsches Primatenzentrum GmbH, Kellnerweg 4, 37077 Göttingen, Germany.; DZHK (German Center for Cardiovascular Research), partner site Göttingen, 37077 Göttingen, Germany.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 12; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cellular Senescence*
Cardiovascular Diseases/*therapy
Mitochondria, Heart/*transplantation
Myocardium/*metabolism
Stem Cells/*metabolism
Animals ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/pathology ; Humans ; Myocardium/pathology ; Stem Cells/pathology
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies