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Wyszukujesz frazę ""Senescence"" wg kryterium: Temat


Starter badań:

Tytuł:
IFN-γ and TNF Induce Senescence and a Distinct Senescence-Associated Secretory Phenotype in Melanoma.
Autorzy:
Homann L; Department of Dermatology, University of Tuebingen, 72076 Tuebingen, Germany.
Rentschler M; Department of Dermatology, University of Tuebingen, 72076 Tuebingen, Germany.; Institute of Physiology I, Department of Vegetative and Clinical Physiology, University of Tuebingen, 72074 Tuebingen, Germany.
Brenner E; Department of Dermatology, University of Tuebingen, 72076 Tuebingen, Germany.
Böhm K; Department of Dermatology, University of Tuebingen, 72076 Tuebingen, Germany.
Röcken M; Department of Dermatology, University of Tuebingen, 72076 Tuebingen, Germany.
Wieder T; Institute of Physiology I, Department of Vegetative and Clinical Physiology, University of Tuebingen, 72074 Tuebingen, Germany.
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Źródło:
Cells [Cells] 2022 Apr 30; Vol. 11 (9). Date of Electronic Publication: 2022 Apr 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Melanoma*/pathology
Senescence-Associated Secretory Phenotype*
Interferon-gamma/*metabolism
Tumor Necrosis Factor-alpha/*metabolism
CD8-Positive T-Lymphocytes/metabolism ; Cellular Senescence ; Humans
Czasopismo naukowe
Tytuł:
The mechanotransduction of MLO-Y4 cells is disrupted by the senescence-associated secretory phenotype of neighboring cells.
Autorzy:
Gardinier JD; Bone and Joint Center, Henry Ford Health System, Henry Ford Hospital, Detroit, Michigan, USA.
Chougule A; Bone and Joint Center, Henry Ford Health System, Henry Ford Hospital, Detroit, Michigan, USA.
Zhang C; Bone and Joint Center, Henry Ford Health System, Henry Ford Hospital, Detroit, Michigan, USA.
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Źródło:
Journal of cellular physiology [J Cell Physiol] 2022 Apr; Vol. 237 (4), pp. 2249-2257. Date of Electronic Publication: 2022 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*
Mechanotransduction, Cellular*
Animals ; Cell Line ; Interleukin-6/metabolism ; Mice ; Osteocytes/metabolism ; Senescence-Associated Secretory Phenotype
Czasopismo naukowe
Tytuł:
Loss of RNA binding protein HuD facilitates the production of the senescence-associated secretory phenotype.
Autorzy:
Ryu S; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, 06591, South Korea.; Department of Biochemistry, The Catholic University of Korea, Seoul, 06591, South Korea.
Jung M; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, 06591, South Korea.; Department of Biochemistry, The Catholic University of Korea, Seoul, 06591, South Korea.
Kim C; Department of Biochemistry, The Catholic University of Korea, Seoul, 06591, South Korea.; Catholic Institute for Visual Science, The Catholic University of Korea, Seoul, 06591, South Korea.
Kang H; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, 06591, South Korea.
Han S; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, 06591, South Korea.; Department of Biochemistry, The Catholic University of Korea, Seoul, 06591, South Korea.
Cha S; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, 06591, South Korea.; Department of Biochemistry, The Catholic University of Korea, Seoul, 06591, South Korea.
Jeong SM; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, 06591, South Korea.; Department of Biochemistry, The Catholic University of Korea, Seoul, 06591, South Korea.; Institute of Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul, 06591, South Korea.
Lee EK; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, 06591, South Korea. .; Department of Biochemistry, The Catholic University of Korea, Seoul, 06591, South Korea. .; Institute of Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul, 06591, South Korea. .
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Źródło:
Cell death & disease [Cell Death Dis] 2022 Apr 11; Vol. 13 (4), pp. 329. Date of Electronic Publication: 2022 Apr 11.
Typ publikacji:
Journal Article
MeSH Terms:
Insulin-Secreting Cells*/metabolism
Senescence-Associated Secretory Phenotype*
ELAV-Like Protein 4/*metabolism
3' Untranslated Regions ; Animals ; Cellular Senescence/genetics ; Ligands ; Mice ; Mice, Knockout ; RNA-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł:
Shear stress-induced cellular senescence blunts liver regeneration through Notch-sirtuin 1-P21/P16 axis.
Autorzy:
Duan JL; Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.
Ruan B; Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China.; Center of Clinical Aerospace Medicine & Department of Aviation Medicine, Fourth Military Medical University, Xi'an, China.
Song P; Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.
Fang ZQ; Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.
Yue ZS; Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.; Department of Ophthalmology, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.
Liu JJ; Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.
Dou GR; Department of Ophthalmology, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.
Han H; Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China.
Wang L; Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.
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Źródło:
Hepatology (Baltimore, Md.) [Hepatology] 2022 Mar; Vol. 75 (3), pp. 584-599. Date of Electronic Publication: 2021 Dec 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence*/drug effects
Cellular Senescence*/physiology
Liver Regeneration*/drug effects
Liver Regeneration*/physiology
Receptors, Notch*/antagonists & inhibitors
Receptors, Notch*/metabolism
Signal Transduction/*drug effects
Sirtuin 1/*metabolism
Animals ; Gamma Secretase Inhibitors and Modulators/pharmacology ; Hepatectomy/methods ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Mice ; Nitric Oxide Synthase Type III/metabolism ; Senescence-Associated Secretory Phenotype/genetics
Czasopismo naukowe
Tytuł:
Cellular senescence-an aging hallmark in chronic obstructive pulmonary disease pathogenesis.
Autorzy:
Araya J; Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan. Electronic address: .
Kuwano K; Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
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Źródło:
Respiratory investigation [Respir Investig] 2022 Jan; Vol. 60 (1), pp. 33-44. Date of Electronic Publication: 2021 Oct 11.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Pulmonary Disease, Chronic Obstructive*/etiology
Senescence-Associated Secretory Phenotype*
Aging ; Autophagy ; Cellular Senescence ; Humans ; Lung
Czasopismo naukowe
Tytuł:
A guide to senolytic intervention in neurodegenerative disease.
Autorzy:
Lee S; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.
Wang EY; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.
Steinberg AB; University of Wisconsin Department of Biochemistry, 433 Babcock Drive., Madison, WI, 53706, USA.
Walton CC; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA. Electronic address: .
Chinta SJ; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA; Touro University California, College of Pharmacy, 1310 Club Dr., Vallejo, CA, 94592, USA. Electronic address: .
Andersen JK; Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA. Electronic address: .
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Źródło:
Mechanisms of ageing and development [Mech Ageing Dev] 2021 Dec; Vol. 200, pp. 111585. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Aging*/drug effects
Aging*/physiology
Cellular Senescence*/drug effects
Cellular Senescence*/physiology
Neurodegenerative Diseases*/drug therapy
Neurodegenerative Diseases*/metabolism
Senotherapeutics/*pharmacology
Animals ; Humans ; Mice ; Senescence-Associated Secretory Phenotype/drug effects
Czasopismo naukowe
Tytuł:
Skeletal muscle aging, cellular senescence, and senotherapeutics: Current knowledge and future directions.
Autorzy:
Englund DA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Zhang X; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Aversa Z; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
LeBrasseur NK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. Electronic address: .
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Źródło:
Mechanisms of ageing and development [Mech Ageing Dev] 2021 Dec; Vol. 200, pp. 111595. Date of Electronic Publication: 2021 Nov 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Cellular Senescence*/drug effects
Cellular Senescence*/physiology
Muscle, Skeletal*/drug effects
Muscle, Skeletal*/metabolism
Muscle, Skeletal*/physiopathology
Sarcopenia*/drug therapy
Sarcopenia*/metabolism
Sarcopenia*/physiopathology
Senotherapeutics/*pharmacology
Humans ; Senescence-Associated Secretory Phenotype/drug effects
Czasopismo naukowe
Tytuł:
The senescence-associated secretory phenotype: Fueling a wound that never heals.
Autorzy:
Pulido T; Buck Institute for Research on Aging, Novato, CA, 94945, USA.
Velarde MC; Institute of Biology, College of Science, University of the Philippines Diliman, Quezon City, 1101, Philippines. Electronic address: .
Alimirah F; Buck Institute for Research on Aging, Novato, CA, 94945, USA. Electronic address: .
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Źródło:
Mechanisms of ageing and development [Mech Ageing Dev] 2021 Oct; Vol. 199, pp. 111561. Date of Electronic Publication: 2021 Aug 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Immunosenescence*
Neoplasms*/immunology
Neoplasms*/pathology
Neoplasms*/therapy
Senescence-Associated Secretory Phenotype*
Wounds and Injuries*/immunology
Wounds and Injuries*/pathology
Wounds and Injuries*/therapy
Cellular Senescence/physiology ; Humans ; Paracrine Communication ; Wound Healing
Czasopismo naukowe
Tytuł:
Human MSC-Derived Exosomes Reduce Cellular Senescence in Renal Epithelial Cells.
Autorzy:
Liao CM; Department of Nephrology and Hypertension, Hannover Medical School, 30625 Hannover, Germany.
Luo T; Biochemistry and Tumor Biology Lab, Department of Gynecology and Obstetrics, Hannover Medical School, 30625 Hannover, Germany.
von der Ohe J; Biochemistry and Tumor Biology Lab, Department of Gynecology and Obstetrics, Hannover Medical School, 30625 Hannover, Germany.
de Juan Mora B; Department of Nephrology and Hypertension, Hannover Medical School, 30625 Hannover, Germany.
Schmitt R; Department of Nephrology and Hypertension, Hannover Medical School, 30625 Hannover, Germany.
Hass R; Biochemistry and Tumor Biology Lab, Department of Gynecology and Obstetrics, Hannover Medical School, 30625 Hannover, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 17; Vol. 22 (24). Date of Electronic Publication: 2021 Dec 17.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*
Epithelial Cells/*cytology
Exosomes/*metabolism
Kidney/*cytology
Mesenchymal Stem Cells/*cytology
Animals ; Cells, Cultured ; Epithelial Cells/metabolism ; Exosomes/transplantation ; Humans ; Kidney/metabolism ; Male ; Mesenchymal Stem Cells/metabolism ; Mice, Inbred C57BL ; Senescence-Associated Secretory Phenotype
Czasopismo naukowe
Tytuł:
A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization.
Autorzy:
Zampetidis CP; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Galanos P; Genome Integrity Group, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark. Electronic address: .
Angelopoulou A; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Zhu Y; Translational Epigenetics Group, Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Polyzou A; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Karamitros T; Unit of Bioinformatics and Applied Genomics, Department of Microbiology, Hellenic Pasteur Institute, 11521 Athens, Greece.
Kotsinas A; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Lagopati N; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Mourkioti I; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Mirzazadeh R; Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Solna, Stockholm, Sweden.
Polyzos A; Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Garnerone S; Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Solna, Stockholm, Sweden.
Mizi A; Translational Epigenetics Group, Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Gusmao EG; Translational Epigenetics Group, Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Sofiadis K; Translational Epigenetics Group, Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Gál Z; Nucleolar Stress and Disease Group, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Larsen DH; Nucleolar Stress and Disease Group, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Pefani DE; Laboratories of Biology, Medical School, University of Patras, 26504 Rio, Greece.
Demaria M; University of Groningen (RUG), European Research Institute for the Biology of Aging (ERIBA), University Medical Center Groningen (UMCG), 9713 AV Groningen, the Netherlands.
Tsirigos A; Department of Pathology, NYU School of Medicine, New York, NY 10016, USA.
Crosetto N; Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Solna, Stockholm, Sweden.
Maya-Mendoza A; DNA Replication and Cancer Group, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Papaspyropoulos A; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Evangelou K; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.
Bartek J; Genome Integrity Group, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark; Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Solna, Stockholm, Sweden. Electronic address: .
Papantonis A; Translational Epigenetics Group, Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany. Electronic address: .
Gorgoulis VG; Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece; Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine & Health, University of Manchester, M20 4GJ Manchester, UK; Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece; Faculty of Health and Medical Sciences, University of Surrey, Surrey GU2 7YH, UK. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2021 Dec 02; Vol. 81 (23), pp. 4907-4923.e8. Date of Electronic Publication: 2021 Nov 17.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*
Chromosome Inversion*
Epithelial-Mesenchymal Transition*
Oncogenes*
Recombination, Genetic*
Chromosomes/*ultrastructure
Neoplasms/*genetics
Animals ; Bronchi/metabolism ; CRISPR-Cas Systems ; Cell Cycle ; Cell Transformation, Neoplastic ; Circadian Rhythm ; Computational Biology ; Epithelial Cells/metabolism ; Flow Cytometry ; Genomics ; Humans ; Karyotyping ; Mice ; Mice, SCID ; Neoplasms/metabolism ; Phenotype ; Protein Binding ; Protein Domains ; Senescence-Associated Secretory Phenotype
Czasopismo naukowe
Tytuł:
Senescent Cells in Cancer: Wanted or Unwanted Citizens.
Autorzy:
Niklander SE; Unidad de Patologia y Medicina Oral, Facultad de Odontologia, Universidad Andres Bello, Viña del Mar 2520000, Chile.
Lambert DW; Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield S10 2TA, UK.; Healthy Lifespan Institute, University of Sheffield, Sheffield S10 2TN, UK.
Hunter KD; Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield S10 2TA, UK.; Oral Biology and Pathology, University of Pretoria, Pretoria 0028, South Africa.
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Źródło:
Cells [Cells] 2021 Nov 26; Vol. 10 (12). Date of Electronic Publication: 2021 Nov 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Cellular Senescence*
Neoplasms/*pathology
Animals ; Biomarkers, Tumor/metabolism ; Humans ; Models, Biological ; Senescence-Associated Secretory Phenotype ; Signal Transduction
Czasopismo naukowe
Tytuł:
Senescent tumor cells: an overlooked adversary in the battle against cancer.
Autorzy:
Park SS; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Korea.; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, 16499, Korea.; Inflamm-Aging Translational Research Center, Ajou University School of Medicine, Suwon, 16499, Korea.
Choi YW; Inflamm-Aging Translational Research Center, Ajou University School of Medicine, Suwon, 16499, Korea.; Department of Hematology-Oncology, Ajou University School of Medicine, Suwon, 16499, Korea.
Kim JH; Inflamm-Aging Translational Research Center, Ajou University School of Medicine, Suwon, 16499, Korea.; Department of Pathology, Ajou University School of Medicine, Suwon, 16499, Korea.
Kim HS; Department of Molecular Medicine, Inha University College of Medicine, Incheon, 22212, Korea. .
Park TJ; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Korea. .; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, 16499, Korea. .; Inflamm-Aging Translational Research Center, Ajou University School of Medicine, Suwon, 16499, Korea. .
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Źródło:
Experimental & molecular medicine [Exp Mol Med] 2021 Dec; Vol. 53 (12), pp. 1834-1841. Date of Electronic Publication: 2021 Dec 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Cellular Senescence*/genetics
Neoplasms/*metabolism
Disease Management ; Disease Susceptibility ; Drug Development ; Gene Expression Regulation ; Humans ; Neoplasms/etiology ; Neoplasms/pathology ; Neoplasms/therapy ; Organ Specificity/genetics ; Senescence-Associated Secretory Phenotype/genetics ; Tumor Microenvironment
Czasopismo naukowe
Tytuł:
TWIST1 controls cellular senescence and energy metabolism in mesenchymal stem cells.
Autorzy:
Voskamp C
Anderson LA
Koevoet WJ
Barnhoorn S
Mastroberardino PG
van Osch GJ
Narcisi R; Department of Orthopaedics and Sports Medicine, Erasmus MC, 3015 CN Rotterdam, the .
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Źródło:
European cells & materials [Eur Cell Mater] 2021 Nov 25; Vol. 42, pp. 401-414. Date of Electronic Publication: 2021 Nov 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mesenchymal Stem Cells*
Senescence-Associated Secretory Phenotype*
Cellular Senescence ; Energy Metabolism ; Gene Expression Regulation
Czasopismo naukowe
Tytuł:
Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls.
Autorzy:
Owens WA; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK; The James Cook University Hospital, Middlesbrough, UK.
Walaszczyk A; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.
Spyridopoulos I; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.
Dookun E; Atelerix Ltd, Newcastle upon Tyne, UK.
Richardson GD; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK. Electronic address: .
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Źródło:
Mechanisms of ageing and development [Mech Ageing Dev] 2021 Sep; Vol. 198, pp. 111540. Date of Electronic Publication: 2021 Jul 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Aging*/immunology
Aging*/metabolism
Cardiovascular Diseases*/etiology
Cardiovascular Diseases*/metabolism
Cardiovascular Diseases*/therapy
Cellular Senescence*/drug effects
Cellular Senescence*/physiology
Apoptosis Regulatory Proteins/*metabolism
Senotherapeutics/*pharmacology
Humans ; Inflammation/metabolism ; Senescence-Associated Secretory Phenotype ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł:
The Cancer SENESCopedia: A delineation of cancer cell senescence.
Autorzy:
Jochems F; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Thijssen B; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
De Conti G; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Jansen R; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Pogacar Z; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Groot K; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Wang L; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Schepers A; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Wang C; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Jin H; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Beijersbergen RL; Division of Molecular Carcinogenesis, The NKI Robotics and Screening Center, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Leite de Oliveira R; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands.
Wessels LFA; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands; Faculty of EEMCS, Delft University of Technology, Delft, the Netherlands. Electronic address: .
Bernards R; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2021 Jul 27; Vol. 36 (4), pp. 109441.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence*/drug effects
Neoplasms/*pathology
Aniline Compounds/pharmacology ; Azepines/pharmacology ; Cell Line, Tumor ; Etoposide/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Neoplasms/genetics ; Pyrimidines/pharmacology ; Reproducibility of Results ; Senescence-Associated Secretory Phenotype/drug effects ; Senescence-Associated Secretory Phenotype/genetics ; Senotherapeutics/pharmacology ; Sulfonamides/pharmacology
Czasopismo naukowe
Tytuł:
α-1 Adrenergic receptor antagonist doxazosin reverses hepatic stellate cells activation via induction of senescence.
Autorzy:
Serna-Salas SA; Dept. Morphology, Autonomous University of Aguascalientes, Aguascalientes, Mexico; Dept. Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Arroyave-Ospina JC; Dept. Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Zhang M; Dept. Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Damba T; Dept. Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; School of Pharmacy, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
Buist-Homan M; Dept. Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Dept. Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Muñoz-Ortega MH; Dept. Chemistry, Autonomous University of Aguascalientes, Aguascalientes, Mexico.
Ventura-Juárez J; Dept. Morphology, Autonomous University of Aguascalientes, Aguascalientes, Mexico. Electronic address: .
Moshage H; Dept. Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Dept. Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
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Źródło:
Mechanisms of ageing and development [Mech Ageing Dev] 2022 Jan; Vol. 201, pp. 111617. Date of Electronic Publication: 2021 Dec 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence*/drug effects
Cellular Senescence*/genetics
Hepatic Stellate Cells*/drug effects
Hepatic Stellate Cells*/metabolism
Liver Cirrhosis*/metabolism
Liver Cirrhosis*/pathology
Liver Cirrhosis*/prevention & control
Doxazosin/*pharmacology
Senescence-Associated Secretory Phenotype/*physiology
Signal Transduction/*drug effects
Adrenergic alpha-1 Receptor Antagonists/pharmacology ; Adrenergic alpha-Agonists/pharmacology ; Animals ; Cell Cycle Checkpoints/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Norepinephrine/pharmacology ; Rats ; Receptors, Adrenergic, alpha-1/metabolism ; Sulfonamides/pharmacology
Czasopismo naukowe
Tytuł:
Coordinated post-transcriptional control of oncogene-induced senescence by UNR/CSDE1.
Autorzy:
Avolio R; Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.
Inglés-Ferrándiz M; Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.
Ciocia A; Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.
Coll O; Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.
Bonnin S; Bioinformatics Unit, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.
Guitart T; Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.
Ribó A; Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.
Gebauer F; Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2022 Jan 11; Vol. 38 (2), pp. 110211.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cellular Senescence/*physiology
DNA-Binding Proteins/*metabolism
RNA-Binding Proteins/*metabolism
Animals ; Cell Cycle Checkpoints/genetics ; Cell Cycle Checkpoints/physiology ; Cell Line ; Cell Proliferation/physiology ; Cellular Senescence/genetics ; DNA-Binding Proteins/physiology ; Female ; Gene Expression/genetics ; Gene Expression Regulation/genetics ; Humans ; Keratinocytes/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Nude ; Oncogenes/genetics ; Primary Cell Culture ; RNA Processing, Post-Transcriptional/physiology ; RNA-Binding Proteins/physiology ; Senescence-Associated Secretory Phenotype/genetics ; Senescence-Associated Secretory Phenotype/physiology ; Signal Transduction/physiology ; Y-Box-Binding Protein 1/metabolism
Czasopismo naukowe
Tytuł:
Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype.
Autorzy:
Kuehnemann C; Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, United States.; Buck Institute for Research on Aging, Novato, CA, United States.
Hu KQ; Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, United States.
Butera K; Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, United States.
Patel SK; Buck Institute for Research on Aging, Novato, CA, United States.
Bons J; Buck Institute for Research on Aging, Novato, CA, United States.
Schilling B; Buck Institute for Research on Aging, Novato, CA, United States.
Aguayo-Mazzucato C; Joslin Diabetes Center, Harvard Medical School, Boston, MA, United States.
Wiley CD; Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, United States.
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Źródło:
Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Jul 14; Vol. 13, pp. 935106. Date of Electronic Publication: 2022 Jul 14 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Cytokines*/genetics
Cytokines*/metabolism
Diabetes Mellitus, Experimental*/metabolism
Nicotinamide Phosphoribosyltransferase*/genetics
Nicotinamide Phosphoribosyltransferase*/metabolism
Senescence-Associated Secretory Phenotype*/genetics
Senescence-Associated Secretory Phenotype*/physiology
AMP-Activated Protein Kinases/metabolism ; Animals ; Mice ; NAD/metabolism
Czasopismo naukowe
Tytuł:
Therapeutic Potential of Senolytics in Cardiovascular Disease.
Autorzy:
Dookun E; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.
Passos JF; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Arthur HM; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.
Richardson GD; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK. .
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Źródło:
Cardiovascular drugs and therapy [Cardiovasc Drugs Ther] 2022 Feb; Vol. 36 (1), pp. 187-196. Date of Electronic Publication: 2020 Sep 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Cardiovascular Diseases/*drug therapy
Cellular Senescence/*drug effects
Senotherapeutics/*pharmacology
Aged ; Aging ; Animals ; Apoptosis/drug effects ; Cardiovascular Diseases/physiopathology ; Disease Progression ; Humans ; Prognosis ; Risk Factors ; Senescence-Associated Secretory Phenotype/physiology
Czasopismo naukowe
Tytuł:
Simple Detection of Unstained Live Senescent Cells with Imaging Flow Cytometry.
Autorzy:
Malavolta M; Advanced Technology Center for Aging Research, IRCCS INRCA, 60121 Ancona, Italy.
Giacconi R; Advanced Technology Center for Aging Research, IRCCS INRCA, 60121 Ancona, Italy.
Piacenza F; Advanced Technology Center for Aging Research, IRCCS INRCA, 60121 Ancona, Italy.
Strizzi S; Advanced Technology Center for Aging Research, IRCCS INRCA, 60121 Ancona, Italy.
Cardelli M; Advanced Technology Center for Aging Research, IRCCS INRCA, 60121 Ancona, Italy.
Bigossi G; Advanced Technology Center for Aging Research, IRCCS INRCA, 60121 Ancona, Italy.
Marcozzi S; Advanced Technology Center for Aging Research, IRCCS INRCA, 60121 Ancona, Italy.
Tiano L; Department of Life and Environmental Sciences, Polytechnical University of Marche, 60121 Ancona, Italy.
Marcheggiani F; Department of Life and Environmental Sciences, Polytechnical University of Marche, 60121 Ancona, Italy.
Matacchione G; Department of Clinical and Molecular Sciences, DISCLIMO, Polytechnical University of Marche, 60121 Ancona, Italy.
Giuliani A; Department of Clinical and Molecular Sciences, DISCLIMO, Polytechnical University of Marche, 60121 Ancona, Italy.
Olivieri F; Department of Clinical and Molecular Sciences, DISCLIMO, Polytechnical University of Marche, 60121 Ancona, Italy.; Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, 60121 Ancona, Italy.
Crivellari I; Department of Medicine (DAME), University of Udine, 33100 Udine, Italy.
Beltrami AP; Department of Medicine (DAME), University of Udine, 33100 Udine, Italy.
Serra A; Luminex B.V., Het Zuiderkruis 1, 5215 MV 's-Hertogenbosch, The Netherlands.
Demaria M; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), 9713 AV Groningen, The Netherlands.
Provinciali M; Advanced Technology Center for Aging Research, IRCCS INRCA, 60121 Ancona, Italy.
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Źródło:
Cells [Cells] 2022 Aug 12; Vol. 11 (16). Date of Electronic Publication: 2022 Aug 12.
Typ publikacji:
Journal Article
MeSH Terms:
Artificial Intelligence*
Cellular Senescence*
Aging ; Biomarkers ; Flow Cytometry/methods ; Humans
Czasopismo naukowe

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