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Wyszukujesz frazę ""Senescence"" wg kryterium: Temat


Tytuł:
β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells.
Autorzy:
Zhang Y; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Mao H; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Li Y; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Xiong Y; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Liu X; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Wang L; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Chen Z; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 14; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 14.
Typ publikacji:
Journal Article
MeSH Terms:
Beta-Cryptoxanthin*/pharmacology
NF-E2-Related Factor 2*/metabolism
Oxidative Stress*/drug effects
Cellular Senescence*/drug effects
Humans ; Hydrogen Peroxide/metabolism ; Mitochondria/metabolism ; Reactive Oxygen Species/metabolism ; Cell Line
Czasopismo naukowe
Tytuł:
Possible Mechanisms of Oxidative Stress-Induced Skin Cellular Senescence, Inflammation, and Cancer and the Therapeutic Potential of Plant Polyphenols.
Autorzy:
Liu HM; School of Perfume & Aroma and Cosmetics, Shanghai Institute of Technology, Shanghai 201418, China.; Engineering Research Center of Perfume & Aroma and Cosmetics, Ministry of Education, Shanghai 201418, China.
Cheng MY; School of Perfume & Aroma and Cosmetics, Shanghai Institute of Technology, Shanghai 201418, China.
Xun MH; School of Perfume & Aroma and Cosmetics, Shanghai Institute of Technology, Shanghai 201418, China.
Zhao ZW; School of Perfume & Aroma and Cosmetics, Shanghai Institute of Technology, Shanghai 201418, China.
Zhang Y; School of Perfume & Aroma and Cosmetics, Shanghai Institute of Technology, Shanghai 201418, China.
Tang W; School of Perfume & Aroma and Cosmetics, Shanghai Institute of Technology, Shanghai 201418, China.
Cheng J; School of Perfume & Aroma and Cosmetics, Shanghai Institute of Technology, Shanghai 201418, China.
Ni J; School of Perfume & Aroma and Cosmetics, Shanghai Institute of Technology, Shanghai 201418, China.
Wang W; School of Perfume & Aroma and Cosmetics, Shanghai Institute of Technology, Shanghai 201418, China.; Engineering Research Center of Perfume & Aroma and Cosmetics, Ministry of Education, Shanghai 201418, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 13; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 13.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cellular Senescence*/physiology
Inflammation*/metabolism
Oxidative Stress*
Polyphenols*/pharmacology
Polyphenols*/therapeutic use
Carcinogenesis*
Humans ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Curcumin/pharmacology ; Neoplasms/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł:
Autophagosome protects proximal tubular cells from aldosterone-induced senescence through improving oxidative stress.
Autorzy:
Cao JY; Department of Nephrology, Taizhou People's Hospital, The Fifth Affiliated Hospital of Nantong University, Taizhou, China.
Ling LL; Department of Nephrology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Ni WJ; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
Guo HL; Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yang M; Department of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
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Źródło:
Renal failure [Ren Fail] 2021 Dec; Vol. 43 (1), pp. 556-565.
Typ publikacji:
Journal Article
MeSH Terms:
Aldosterone/*pharmacology
Autophagosomes/*drug effects
Cellular Senescence/*drug effects
Kidney/*metabolism
Oxidative Stress/*drug effects
Aldosterone/administration & dosage ; Animals ; Cell Line ; Cells, Cultured ; Cellular Senescence/physiology ; Epithelial Cells/metabolism ; Humans ; Kidney/cytology ; Kidney/drug effects ; Male ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł:
A single dose of Ultraviolet-A induces proteome remodeling and senescence in primary human keratinocytes.
Autorzy:
Valerio HP; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, 05508-000, Brazil. .
Ravagnani FG; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, 05508-000, Brazil.
Ronsein GE; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, 05508-000, Brazil. .
Di Mascio P; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, 05508-000, Brazil. .
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Źródło:
Scientific reports [Sci Rep] 2021 Dec 02; Vol. 11 (1), pp. 23355. Date of Electronic Publication: 2021 Dec 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence*
Oxidative Stress*
Inflammation/*pathology
Inflammation Mediators/*metabolism
Keratinocytes/*pathology
Proteome/*metabolism
Ultraviolet Rays/*adverse effects
Antioxidants/metabolism ; Humans ; Inflammation/etiology ; Inflammation/metabolism ; Keratinocytes/immunology ; Keratinocytes/metabolism ; Keratinocytes/radiation effects ; Proteome/analysis ; Proteome/radiation effects
Czasopismo naukowe
Tytuł:
Selective Cardiomyocyte Oxidative Stress Leads to Bystander Senescence of Cardiac Stromal Cells.
Autorzy:
Martini H; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.; Institute Cardiomet, FHU IMPACT, University Hospital of Toulouse, 31400 Toulouse, France.
Lefevre L; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.
Sayir S; Institute Cardiomet, FHU IMPACT, University Hospital of Toulouse, 31400 Toulouse, France.
Itier R; Institute Cardiomet, FHU IMPACT, University Hospital of Toulouse, 31400 Toulouse, France.
Maggiorani D; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.
Dutaur M; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.
Marsal DJ; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.
Roncalli J; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.; Institute Cardiomet, FHU IMPACT, University Hospital of Toulouse, 31400 Toulouse, France.
Pizzinat N; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.
Cussac D; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.
Parini A; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.; Institute Cardiomet, FHU IMPACT, University Hospital of Toulouse, 31400 Toulouse, France.
Mialet-Perez J; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.
Douin-Echinard V; Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 24; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 24.
Typ publikacji:
Journal Article
MeSH Terms:
Bystander Effect*
Cellular Senescence*
Oxidative Stress*
Aging/*pathology
Monoamine Oxidase/*physiology
Myocytes, Cardiac/*pathology
Stromal Cells/*pathology
Aging/metabolism ; Animals ; Cells, Cultured ; DNA Damage ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Myocytes, Cardiac/metabolism ; Stromal Cells/metabolism
Czasopismo naukowe
Tytuł:
Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice.
Autorzy:
Blasiak J; Department of Molecular Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Koskela A; Department of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland.
Pawlowska E; Department of Orthodontics, Medical University of Lodz, 92-217 Lodz, Poland.
Liukkonen M; Department of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland.
Ruuth J; Department of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland.
Toropainen E; Department of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland.
Hyttinen JMT; Department of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland.
Viiri J; Department of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland.
Eriksson JE; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.; Cell Biology, Faculty of Science and Technology, Åbo Akademi University, 20500 Turku, Finland.
Xu H; The Wellcome-Wolfson Institute of Experimental Medicine Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK.
Chen M; The Wellcome-Wolfson Institute of Experimental Medicine Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK.
Felszeghy S; Institute of Biomedicine, University of Eastern Finland, Yliopistonranta 1 A, 70211 Kuopio, Finland.; Institute of Dentistry, University of Eastern Finland, Yliopistonranta 1 C, 70211 Kuopio, Finland.
Kaarniranta K; Department of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland.; Department of Ophthalmology, Kuopio University Hospital, 70210 Kuopio, Finland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 08; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 08.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*
Epithelial-Mesenchymal Transition*
Oxidative Stress*
Mitochondria/*pathology
NF-E2-Related Factor 2/*physiology
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/*physiology
Retinal Pigment Epithelium/*pathology
Animals ; Macular Degeneration ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Mitochondria/genetics ; Mitochondria/metabolism ; Phenotype ; Reactive Oxygen Species/metabolism ; Retinal Pigment Epithelium/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł:
Effect of a Topical Collagen Tripeptide on Antiaging and Inhibition of Glycation of the Skin: A Pilot Study.
Autorzy:
Lee YI; Department of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea.; Scar Laser and Plastic Surgery Center, Yonsei Cancer Hospital, Seoul 03722, Korea.
Lee SG; Department of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea.
Jung I; Global Medical Research Center, Seoul 06526, Korea.
Suk J; Global Medical Research Center, Seoul 06526, Korea.
Lee MH; Health Food Research and Development, NEWTREE Co., Ltd., Seoul 05604, Korea.
Kim DU; Health Food Research and Development, NEWTREE Co., Ltd., Seoul 05604, Korea.
Lee JH; Department of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea.; Scar Laser and Plastic Surgery Center, Yonsei Cancer Hospital, Seoul 03722, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 20; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 20.
Typ publikacji:
Journal Article
MeSH Terms:
Oxidative Stress*
Cellular Senescence/*drug effects
Collagen/*pharmacology
Glycation End Products, Advanced/*antagonists & inhibitors
Peptide Fragments/*pharmacology
Skin/*drug effects
Skin Aging/*drug effects
Adult ; Case-Control Studies ; Elasticity ; Female ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Glycosylation ; Humans ; Middle Aged ; Pilot Projects ; Prospective Studies ; Reactive Oxygen Species/metabolism ; Skin/metabolism ; Skin Aging/pathology
Czasopismo naukowe
Tytuł:
miR-24 and its target gene Prdx6 regulate viability and senescence of myogenic progenitors during aging.
Autorzy:
Soriano-Arroquia A; Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.; The Medical Research Council/Versus Arthritis Centre for Integrated Research into Musculoskeletal Aging, CIMA, University of Liverpool, Liverpool, UK.
Gostage J; The Medical Research Council/Versus Arthritis Centre for Integrated Research into Musculoskeletal Aging, CIMA, University of Liverpool, Liverpool, UK.; Discipline of Physiology, School of Medicine, National University of Ireland, Galway, Ireland.; Department of Oncology and Metabolism, Healthy Lifespan Institute and the Centre for Integrated Research in Musculoskeletal Aging, University of Sheffield, Sheffield, UK.
Xia Q; Discipline of Physiology, School of Medicine, National University of Ireland, Galway, Ireland.
Bardell D; Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.; The Medical Research Council/Versus Arthritis Centre for Integrated Research into Musculoskeletal Aging, CIMA, University of Liverpool, Liverpool, UK.
McCormick R; Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.; The Medical Research Council/Versus Arthritis Centre for Integrated Research into Musculoskeletal Aging, CIMA, University of Liverpool, Liverpool, UK.
McCloskey E; The Medical Research Council/Versus Arthritis Centre for Integrated Research into Musculoskeletal Aging, CIMA, University of Liverpool, Liverpool, UK.; Department of Oncology and Metabolism, Healthy Lifespan Institute and the Centre for Integrated Research in Musculoskeletal Aging, University of Sheffield, Sheffield, UK.
Bellantuono I; The Medical Research Council/Versus Arthritis Centre for Integrated Research into Musculoskeletal Aging, CIMA, University of Liverpool, Liverpool, UK.; Department of Oncology and Metabolism, Healthy Lifespan Institute and the Centre for Integrated Research in Musculoskeletal Aging, University of Sheffield, Sheffield, UK.
Clegg P; Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.; The Medical Research Council/Versus Arthritis Centre for Integrated Research into Musculoskeletal Aging, CIMA, University of Liverpool, Liverpool, UK.
McDonagh B; Discipline of Physiology, School of Medicine, National University of Ireland, Galway, Ireland.
Goljanek-Whysall K; Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.; The Medical Research Council/Versus Arthritis Centre for Integrated Research into Musculoskeletal Aging, CIMA, University of Liverpool, Liverpool, UK.; Discipline of Physiology, School of Medicine, National University of Ireland, Galway, Ireland.
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Źródło:
Aging cell [Aging Cell] 2021 Oct; Vol. 20 (10), pp. e13475. Date of Electronic Publication: 2021 Sep 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aging/*genetics
Cellular Senescence/*physiology
MicroRNAs/*metabolism
Muscle Development/*genetics
Oxidative Stress/*genetics
Peroxiredoxin VI/*metabolism
Animals ; Humans ; Mice
Czasopismo naukowe
Tytuł:
Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells.
Autorzy:
Bidault G; Institut Hospitalo-Universitaire de Cardiométabolisme et Nutrition (ICAN), RHU CARMMA, Centre de Recherche Saint-Antoine, INSERM UMR_S 938, Sorbonne Université, 75012 Paris, France.
Garcia M; Institut Hospitalo-Universitaire de Cardiométabolisme et Nutrition (ICAN), RHU CARMMA, Centre de Recherche Saint-Antoine, INSERM UMR_S 938, Sorbonne Université, 75012 Paris, France.
Capeau J; Institut Hospitalo-Universitaire de Cardiométabolisme et Nutrition (ICAN), RHU CARMMA, Centre de Recherche Saint-Antoine, INSERM UMR_S 938, Sorbonne Université, 75012 Paris, France.
Morichon R; Cytometry and Imagery platform Saint-Antoine (CISA), Inserm UMS30 Lumic, 75012 Paris, France.
Vigouroux C; Institut Hospitalo-Universitaire de Cardiométabolisme et Nutrition (ICAN), RHU CARMMA, Centre de Recherche Saint-Antoine, INSERM UMR_S 938, Sorbonne Université, 75012 Paris, France.; Laboratoire Commun de Biologie et Génétique Moléculaires, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, 75012 Paris, France.; Service d'Endocrinologie, Diabétologie et Endocrinologie de la Reproduction, Centre National de Référence des Pathologies Rares de l'Insulino-Sécrétion et de l'Insulino-Sensibilité (PRISIS), Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, 75012 Paris, France.
Béréziat V; Institut Hospitalo-Universitaire de Cardiométabolisme et Nutrition (ICAN), RHU CARMMA, Centre de Recherche Saint-Antoine, INSERM UMR_S 938, Sorbonne Université, 75012 Paris, France.
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Źródło:
Cells [Cells] 2020 May 12; Vol. 9 (5). Date of Electronic Publication: 2020 May 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence*
Oxidative Stress*
Coronary Vessels/*pathology
Endothelial Cells/*pathology
Inflammation/*pathology
Lamin Type A/*metabolism
Cell Nucleus/metabolism ; Cell Nucleus Shape ; Cells, Cultured ; DNA Damage ; Endothelial Cells/metabolism ; Humans ; Nitric Oxide Synthase/metabolism ; Protein Prenylation
Czasopismo naukowe
Tytuł:
Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake.
Autorzy:
Rysz J; Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, 113 Żeromskiego Street, 90-549 Lodz, Poland.
Franczyk B; Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, 113 Żeromskiego Street, 90-549 Lodz, Poland.
Rysz-Górzyńska M; Department of Ophthalmology and Visual Rehabilitation, Medical University of Lodz, 113 Żeromskiego Street, 90-549 Lodz, Poland.
Gluba-Brzózka A; Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, 113 Żeromskiego Street, 90-549 Lodz, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 24; Vol. 23 (1). Date of Electronic Publication: 2021 Dec 24.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Aging*
Diet*
Oxidative Stress*
Cardiovascular Diseases/*etiology
Cardiovascular Diseases/diet therapy ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/physiopathology ; Carotenoids ; Cellular Senescence ; Flavonoids ; Humans ; Resveratrol ; Risk Factors
Czasopismo naukowe
Tytuł:
Resveratrol Hinders Postovulatory Aging by Modulating Oxidative Stress in Porcine Oocytes.
Autorzy:
Abbasi B; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Dong Y; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Rui R; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Oct 20; Vol. 26 (21). Date of Electronic Publication: 2021 Oct 20.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence/*drug effects
Oocytes/*drug effects
Oocytes/*metabolism
Ovulation/*drug effects
Ovulation/*metabolism
Oxidative Stress/*drug effects
Resveratrol/*pharmacology
Aging/drug effects ; Aging/metabolism ; Animals ; Antioxidants/pharmacology ; Membrane Potential, Mitochondrial/drug effects ; Reactive Oxygen Species/metabolism ; Swine
Czasopismo naukowe
Tytuł:
Stress-induced and ATF7-dependent epigenetic change influences cellular senescence.
Autorzy:
Maekawa T; RIKEN Cluster for Pioneering Research, Tsukuba, Japan.
Liu B; RIKEN Cluster for Pioneering Research, Tsukuba, Japan.
Liu Y; RIKEN Cluster for Pioneering Research, Tsukuba, Japan.
Yoshida K; RIKEN Cluster for Pioneering Research, Tsukuba, Japan.
Muratani M; Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Chatton B; UMR7242 Biotechnologie et Signalisation Cellulaire, Université de Strasbourg, Illkirch, France.
Ishii S; RIKEN Cluster for Pioneering Research, Tsukuba, Japan.; Department of Functional Genomics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
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Źródło:
Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2019 Sep; Vol. 24 (9), pp. 627-635. Date of Electronic Publication: 2019 Jul 30.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence*
Epigenesis, Genetic*
Oxidative Stress*
Activating Transcription Factors/*metabolism
Activating Transcription Factors/genetics ; Animals ; Cells, Cultured ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Female ; Histones/genetics ; Histones/metabolism ; Longevity ; Male ; Mice ; Mice, Inbred C57BL ; Promoter Regions, Genetic ; Protein Binding ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł:
Complex Positive Effects of SGLT-2 Inhibitor Empagliflozin in the Liver, Kidney and Adipose Tissue of Hereditary Hypertriglyceridemic Rats: Possible Contribution of Attenuation of Cell Senescence and Oxidative Stress.
Autorzy:
Trnovska J; Cardiometabolic Research Division, Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
Svoboda P; Cardiometabolic Research Division, Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.; Laboratory of Animal Biochemistry, Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, 166 28 Prague, Czech Republic.
Pelantova H; Laboratory of Molecular Structure Characterization, Institute of Microbiology, Czech Academy of Sciences, 142 20 Prague, Czech Republic.
Kuzma M; Laboratory of Molecular Structure Characterization, Institute of Microbiology, Czech Academy of Sciences, 142 20 Prague, Czech Republic.; Department of Analytical Chemistry, Faculty of Science, Palacky University Olomouc, 779 00 Olomouc, Czech Republic.
Kratochvilova H; Cardiometabolic Research Division, Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
Kasperova BJ; Diabetes Centre, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
Dvorakova I; Cardiometabolic Research Division, Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
Rosolova K; Laboratory of Animal Biochemistry, Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, 166 28 Prague, Czech Republic.; Diabetes Centre, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
Malinska H; Cardiometabolic Research Division, Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
Huttl M; Cardiometabolic Research Division, Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
Markova I; Cardiometabolic Research Division, Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
Oliyarnyk O; Cardiometabolic Research Division, Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
Melcova M; Laboratory of Animal Biochemistry, Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, 166 28 Prague, Czech Republic.
Skop V; Cardiometabolic Research Division, Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.; Laboratory of Animal Biochemistry, Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, 166 28 Prague, Czech Republic.
Mraz M; Diabetes Centre, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
Stemberkova-Hubackova S; Laboratory of Molecular Therapy, Institute of Biotechnology, Czech Academy of Sciences, 252 50 Prague, Czech Republic.
Haluzik M; Diabetes Centre, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.; Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, 128 08 Prague, Czech Republic.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 30; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 30.
Typ publikacji:
Journal Article
MeSH Terms:
Adipose Tissue/*metabolism
Benzhydryl Compounds/*administration & dosage
Cellular Senescence/*drug effects
Gluconeogenesis/*drug effects
Glucosides/*administration & dosage
Hypertriglyceridemia/*drug therapy
Hypertriglyceridemia/*metabolism
Hypoglycemic Agents/*administration & dosage
Kidney/*metabolism
Lipogenesis/*drug effects
Liver/*metabolism
Oxidative Stress/*drug effects
Sodium-Glucose Transporter 2 Inhibitors/*administration & dosage
3T3-L1 Cells ; Administration, Oral ; Animals ; Cell Survival/drug effects ; Disease Models, Animal ; Down-Regulation/drug effects ; Dyslipidemias/drug therapy ; Gluconeogenesis/genetics ; Hep G2 Cells ; Humans ; Insulin Resistance ; Lipogenesis/genetics ; Male ; Mice ; Rats ; Treatment Outcome ; Up-Regulation/drug effects ; Weight Gain/drug effects
Czasopismo naukowe
Tytuł:
Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies.
Autorzy:
Scaife PJ; Clinical, Metabolic and Molecular Physiology Research Group, University of Nottingham, Nottingham NG7 2RD, UK.
Simpson A; Department of Obstetrics & Gynaecology, University of Nottingham, Nottingham NG7 2RD, UK.
Kurlak LO; School of Veterinary Medicine and Science, University of Nottingham, Nottingham NG7 2RD, UK.
Briggs LV; School of Engineering, University of Nottingham, Nottingham NG7 2RD, UK.
Gardner DS; School of Veterinary Medicine and Science, University of Nottingham, Nottingham NG7 2RD, UK.
Broughton Pipkin F; Department of Obstetrics & Gynaecology, University of Nottingham, Nottingham NG7 2RD, UK.
Jones CJP; Maternal & Fetal Health Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PL, UK.
Mistry HD; Department of Women and Children's Health, School of Life Course Sciences, King's College London, London SE5 9NU, UK.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 07; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 07.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Senescence/*physiology
Oxidative Stress/*physiology
Placenta/*physiology
Pre-Eclampsia/*physiopathology
Adult ; Biomarkers/metabolism ; Female ; Gestational Age ; Humans ; Placenta/metabolism ; Pre-Eclampsia/metabolism ; Pregnancy ; Pregnancy Outcome ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł:
Licochalcone D Ameliorates Oxidative Stress-Induced Senescence via AMPK Activation.
Autorzy:
Maharajan N; Department of Biology, College of Natural Sciences, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 501759, Korea.; BK21-Plus Research Team for Bioactive Control Technology, Department of Life Science, Chosun University, Gwangju 61452, Korea.
Ganesan CD; Department of Biology, College of Natural Sciences, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 501759, Korea.
Moon C; Department of Veterinary Anatomy, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Korea.
Jang CH; Department of Otolaryngology, Chonnam National University Medical School, Gwangju 61469, Korea.
Oh WK; Korea Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
Cho GW; Department of Biology, College of Natural Sciences, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 501759, Korea.; BK21-Plus Research Team for Bioactive Control Technology, Department of Life Science, Chosun University, Gwangju 61452, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 07; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 07.
Typ publikacji:
Journal Article
MeSH Terms:
AMP-Activated Protein Kinases/*metabolism
Cellular Senescence/*drug effects
Chalcones/*pharmacology
Oxidative Stress/*drug effects
Aging/drug effects ; Aging/metabolism ; Animals ; Antioxidants/pharmacology ; Autophagy/drug effects ; Cardiotonic Agents/pharmacology ; Cells, Cultured ; Galactose/metabolism ; Heart/drug effects ; Hippocampus/drug effects ; Hippocampus/metabolism ; Humans ; Hydrogen Peroxide/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Receptor for Advanced Glycation End Products/metabolism ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł:
Glucose-induced oxidative stress and accelerated aging in endothelial cells are mediated by the depletion of mitochondrial SIRTs.
Autorzy:
Liu J; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada.; Mudanjiang Medical University, Heilongjiang, PR China.
Chen S; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada.
Biswas S; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada.
Nagrani N; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada.
Chu Y; Mudanjiang Medical University, Heilongjiang, PR China.
Chakrabarti S; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada.
Feng B; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada.
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Źródło:
Physiological reports [Physiol Rep] 2020 Feb; Vol. 8 (3), pp. e14331.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence*
Oxidative Stress*
Diabetic Cardiomyopathies/*metabolism
Diabetic Retinopathy/*metabolism
Endothelial Cells/*metabolism
Sirtuins/*metabolism
Animals ; Cells, Cultured ; Endothelial Cells/drug effects ; Endothelium, Vascular/cytology ; Endothelium, Vascular/metabolism ; Glucose/pharmacology ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Myocardium/metabolism ; Retina/metabolism ; Sirtuins/genetics
Czasopismo naukowe
Tytuł:
Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease.
Autorzy:
Trist BG; Brain and Mind Centre and Discipline of Pharmacology, Faculty of Medical and Health, The University of Sydney, Sydney, NSW, Australia.
Hare DJ; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Vic., Australia.; Elemental Bio-imaging Facility, University of Technology Sydney, Broadway, NSW, Australia.
Double KL; Brain and Mind Centre and Discipline of Pharmacology, Faculty of Medical and Health, The University of Sydney, Sydney, NSW, Australia.
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Źródło:
Aging cell [Aging Cell] 2019 Dec; Vol. 18 (6), pp. e13031. Date of Electronic Publication: 2019 Aug 20.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Aging*/metabolism
Cellular Senescence*
Oxidative Stress*
Parkinson Disease/*etiology
Parkinson Disease/*metabolism
Substantia Nigra/*metabolism
Animals ; Calcium/metabolism ; Humans ; Mitochondria/metabolism ; Mitochondria/pathology ; Parkinson Disease/pathology ; Substantia Nigra/pathology
Czasopismo naukowe
Tytuł:
The Absence of Tryptase Mcpt6 Causes Elevated Cellular Stress in Response to Modulation of the Histone Acetylation Status in Mast Cells.
Autorzy:
Santosh Martin S; Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, 75123 Uppsala, Sweden. .
Rabelo Melo F; Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, 75123 Uppsala, Sweden. .
Pejler G; Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, 75123 Uppsala, Sweden. .; Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, 75007 Uppsala, Sweden. .
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Źródło:
Cells [Cells] 2019 Oct 02; Vol. 8 (10). Date of Electronic Publication: 2019 Oct 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence/*physiology
Histones/*metabolism
Mast Cells/*physiology
Oxidative Stress/*physiology
Tryptases/*physiology
Acetylation ; Animals ; Cells, Cultured ; Cellular Senescence/genetics ; Histone Deacetylase Inhibitors/pharmacology ; Hydroxamic Acids/pharmacology ; Mast Cells/drug effects ; Mast Cells/enzymology ; Mice ; Oxidative Stress/genetics ; Tryptases/genetics
Czasopismo naukowe
Tytuł:
Transcriptomic Analysis of HCN-2 Cells Suggests Connection among Oxidative Stress, Senescence, and Neuron Death after SARS-CoV-2 Infection.
Autorzy:
Valeri A; IRCCS Centro Neurolesi 'Bonino-Pulejo', Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.
Chiricosta L; IRCCS Centro Neurolesi 'Bonino-Pulejo', Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.
Calcaterra V; Department of Paediatrics, Ospedale dei Bambini 'Vittore Buzzi', 20154 Milano, Italy.; Paediatrics and Adolescentology Unit, Department of Internal Medicine, University of Pavia, 27100 Pavia, Italy.
Biasin M; Department of Biomedical and Clinical Sciences-L. Sacco, University of Milan, 20157 Milan, Italy.
Cappelletti G; Department of Biomedical and Clinical Sciences-L. Sacco, University of Milan, 20157 Milan, Italy.
Carelli S; Paediatric Clinical Research Center Fondazione Romeo ed Enrica Invernizzi, University of Milan, 20157 Milan, Italy.
Zuccotti GV; Department of Paediatrics, Ospedale dei Bambini 'Vittore Buzzi', 20154 Milano, Italy.; Department of Biomedical and Clinical Sciences-L. Sacco, University of Milan, 20157 Milan, Italy.
Bramanti P; IRCCS Centro Neurolesi 'Bonino-Pulejo', Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.
Pelizzo G; Department of Biomedical and Clinical Sciences-L. Sacco, University of Milan, 20157 Milan, Italy.; Paediatric Surgery Unit, Ospedale dei Bambini 'Vittore Buzzi', 20154 Milano, Italy.
Mazzon E; IRCCS Centro Neurolesi 'Bonino-Pulejo', Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.
Gugliandolo A; IRCCS Centro Neurolesi 'Bonino-Pulejo', Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.
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Źródło:
Cells [Cells] 2021 Aug 25; Vol. 10 (9). Date of Electronic Publication: 2021 Aug 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Profiling*
COVID-19/*genetics
COVID-19/*virology
Cellular Senescence/*genetics
Neurons/*pathology
Oxidative Stress/*genetics
SARS-CoV-2/*physiology
Caspase 3/metabolism ; Cell Death ; Cell Line ; Cyclooxygenase 2/metabolism ; Humans ; Superoxide Dismutase/metabolism ; Virus Replication/physiology
Czasopismo naukowe
Tytuł:
DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat.
Autorzy:
Boughey H; The Healthy Lifespan Institute and the Institute of Neuroscience, University of Sheffield, Sheffield S10 2TN, UK.
Jurga M; The Institute of Cancer Therapeutics, University of Bradford, Bradford BD7 1DP, UK.
El-Khamisy SF; The Healthy Lifespan Institute and the Institute of Neuroscience, University of Sheffield, Sheffield S10 2TN, UK.; The Institute of Cancer Therapeutics, University of Bradford, Bradford BD7 1DP, UK.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 02; Vol. 22 (11). Date of Electronic Publication: 2021 Jun 02.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Adaptation, Physiological/*genetics
Cellular Senescence/*genetics
DNA Damage/*genetics
Oxidative Stress/*genetics
Aging/genetics ; Animals ; DNA/genetics ; Homeostasis ; Mole Rats/genetics ; Oxidative Stress/physiology
Czasopismo naukowe

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