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Tytuł :
A pharmacological interactome between COVID-19 patient samples and human sensory neurons reveals potential drivers of neurogenic pulmonary dysfunction.
Autorzy :
Ray PR; University of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, Pain Neurobiology Research Group, USA. Electronic address: .
Wangzhou A; University of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, Pain Neurobiology Research Group, USA.
Ghneim N; University of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, Pain Neurobiology Research Group, USA.
Yousuf MS; University of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, Pain Neurobiology Research Group, USA.
Paige C; University of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, Pain Neurobiology Research Group, USA.
Tavares-Ferreira D; University of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, Pain Neurobiology Research Group, USA.
Mwirigi JM; University of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, Pain Neurobiology Research Group, USA.
Shiers S; University of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, Pain Neurobiology Research Group, USA.
Sankaranarayanan I; University of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, Pain Neurobiology Research Group, USA.
McFarland AJ; University of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, Pain Neurobiology Research Group, USA.
Neerukonda SV; University of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, Pain Neurobiology Research Group, USA.
Davidson S; University of Cincinnati, College of Medicine, Department of Anesthesiology, USA.
Dussor G; University of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, Pain Neurobiology Research Group, USA.
Burton MD; University of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, Neuroimmunology and Behavior Research Group, USA.
Price TJ; University of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, Pain Neurobiology Research Group, USA. Electronic address: .
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Źródło :
Brain, behavior, and immunity [Brain Behav Immun] 2020 Oct; Vol. 89, pp. 559-568. Date of Electronic Publication: 2020 Jun 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bronchoalveolar Lavage Fluid/*immunology
Coronavirus Infections/*immunology
Cytokines/*immunology
Lung/*immunology
Lung/*innervation
Pneumonia, Viral/*immunology
Receptors, Cytokine/*immunology
Sensory Receptor Cells/*immunology
Antirheumatic Agents/therapeutic use ; Betacoronavirus ; Coronavirus Infections/drug therapy ; Coronavirus Infections/metabolism ; Cytokines/metabolism ; Databases, Factual ; Ganglia, Spinal ; Humans ; Lung/metabolism ; Lung/physiopathology ; Molecular Targeted Therapy ; Nociceptors/metabolism ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/metabolism ; RNA-Seq ; Receptors, Cytokine/metabolism ; Respiratory Distress Syndrome, Adult/immunology ; Respiratory Distress Syndrome, Adult/metabolism ; Respiratory Distress Syndrome, Adult/physiopathology ; Sensory Receptor Cells/metabolism ; Transcriptome ; Up-Regulation
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves.
Autorzy :
Eichel MA; Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075, Göttingen, Germany.
Gargareta VI; Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075, Göttingen, Germany.
D'Este E; Department of Nanobiophotonics, Max Planck Institute for Biophysical Chemistry, 37077, Göttingen, Germany.; Optical Microscopy Facility, Max Planck Institute for Medical Research, 69120, Heidelberg, Germany.
Fledrich R; Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075, Göttingen, Germany.; Institute of Anatomy, University of Leipzig, 04103, Leipzig, Germany.
Kungl T; Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075, Göttingen, Germany.; Institute of Anatomy, University of Leipzig, 04103, Leipzig, Germany.
Buscham TJ; Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075, Göttingen, Germany.
Lüders KA; Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075, Göttingen, Germany.
Miracle C; Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075, Göttingen, Germany.
Jung RB; Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075, Göttingen, Germany.
Distler U; Institute of Immunology, University Medical Center, Johannes Gutenberg University, 55131, Mainz, Germany.; Focus Program Translational Neuroscience, University Medical Center, Johannes Gutenberg University, 55131, Mainz, Germany.
Kusch K; Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075, Göttingen, Germany.
Möbius W; Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075, Göttingen, Germany.; Electron Microscopy Core Unit, Max Planck Institute of Experimental Medicine, 37075, Göttingen, Germany.
Hülsmann S; Clinic for Anesthesiology, University Medical Center, 37073, Göttingen, Germany.
Tenzer S; Institute of Immunology, University Medical Center, Johannes Gutenberg University, 55131, Mainz, Germany.
Nave KA; Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075, Göttingen, Germany.
Werner HB; Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075, Göttingen, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Sep 09; Vol. 11 (1), pp. 4514. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Axons/*metabolism
Myelin Proteins/*metabolism
Peripheral Nerves/*cytology
Schwann Cells/*metabolism
Sensory Receptor Cells/*metabolism
Animals ; Axons/ultrastructure ; Cell Membrane/metabolism ; Cell Membrane/ultrastructure ; Cryoelectron Microscopy ; Male ; Mice ; Mice, Knockout ; Myelin Sheath/metabolism ; Neural Conduction ; Peripheral Nerves/metabolism ; Peripheral Nerves/ultrastructure ; Proteomics ; Schwann Cells/cytology ; Schwann Cells/ultrastructure ; Sensory Receptor Cells/cytology ; Sensory Receptor Cells/ultrastructure
Czasopismo naukowe
Tytuł :
Cancer Exacerbates Chemotherapy-Induced Sensory Neuropathy.
Autorzy :
Housley SN; School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia.
Nardelli P; School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia.
Carrasco DI; School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia.
Rotterman TM; School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia.
Pfahl E; School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia.
Matyunina LV; School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia.; Integrated Cancer Research Center, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.
McDonald JF; School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia.; Integrated Cancer Research Center, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.
Cope TC; School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia. .; W.H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Georgia Institute of Technology, Atlanta, Georgia.; Integrated Cancer Research Center, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.
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Źródło :
Cancer research [Cancer Res] 2020 Jul 01; Vol. 80 (13), pp. 2940-2955. Date of Electronic Publication: 2020 Apr 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Disease Models, Animal*
Biomarkers, Tumor/*genetics
Colorectal Neoplasms/*drug therapy
Gene Expression Regulation, Neoplastic/*drug effects
Oxaliplatin/*toxicity
Peripheral Nervous System Diseases/*pathology
Sensory Receptor Cells/*pathology
Animals ; Antineoplastic Agents/toxicity ; Colorectal Neoplasms/pathology ; Gene Expression Profiling ; Male ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/genetics ; Rats ; Rats, Inbred F344 ; Sensory Receptor Cells/drug effects ; Sensory Receptor Cells/metabolism
Czasopismo naukowe
Tytuł :
Satellite glial cells promote regenerative growth in sensory neurons.
Autorzy :
Avraham O; Department of Neuroscience, Washington University School of Medicine, St Louis, MO, 63110, USA.
Deng PY; Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO, 63110, USA.
Jones S; Department of Neuroscience, Washington University School of Medicine, St Louis, MO, 63110, USA.
Kuruvilla R; Department of Biology, Johns Hopkins University, Baltimore, MD, 21218, USA.
Semenkovich CF; Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO, 63110, USA.; Division of Endocrinology, Metabolism & Lipid Research, Washington University School of Medicine, St Louis, MO, 63110, USA.
Klyachko VA; Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO, 63110, USA.
Cavalli V; Department of Neuroscience, Washington University School of Medicine, St Louis, MO, 63110, USA. .; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA. .; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, 63110, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Sep 29; Vol. 11 (1), pp. 4891. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Nerve Regeneration*
Neuroglia/*cytology
Sensory Receptor Cells/*cytology
Animals ; Axons/physiology ; Cell Proliferation ; Fatty Acid Synthases/genetics ; Fatty Acid Synthases/metabolism ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Neuroglia/metabolism ; PPAR alpha/genetics ; PPAR alpha/metabolism ; Peripheral Nerve Injuries/genetics ; Peripheral Nerve Injuries/metabolism ; Peripheral Nerve Injuries/physiopathology ; Peripheral Nerves/growth & development ; Peripheral Nerves/metabolism ; Peripheral Nerves/physiopathology ; Sensory Receptor Cells/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
[Severe sensory-motor axonal neuropathy following diabetic ketoacidosis].
Autorzy :
Hamada Y; Department of Neurology, Teikyo University School of Medicine.
Takahashi K; Department of Neurology, Teikyo University School of Medicine.
Hokkoku K; Department of Neurology, Teikyo University School of Medicine.
Kanbayashi T; Department of Neurology, Teikyo University School of Medicine.
Hatanaka Y; Department of Neurology, Teikyo University School of Medicine.
Kobayashi S; Department of Neurology, Teikyo University School of Medicine.
Sonoo M; Department of Neurology, Teikyo University School of Medicine.
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Źródło :
Rinsho shinkeigaku = Clinical neurology [Rinsho Shinkeigaku] 2020 Sep 29; Vol. 60 (9), pp. 614-619. Date of Electronic Publication: 2020 Aug 08.
Typ publikacji :
Case Reports; Journal Article; Review
MeSH Terms :
Axons*
Motor Neurons*
Sensory Receptor Cells*
Diabetic Ketoacidosis/*complications
Hypoglycemic Agents/*adverse effects
Polyneuropathies/*etiology
Acute Disease ; Adolescent ; Diabetic Ketoacidosis/drug therapy ; Diffusion Magnetic Resonance Imaging ; Humans ; Immunoglobulins, Intravenous/administration & dosage ; Lower Extremity ; Male ; Polyneuropathies/diagnostic imaging ; Polyneuropathies/therapy ; Severity of Illness Index ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Current and emerging systemic treatments targeting the neural system for chronic pruritus.
Autorzy :
Golpanian RS; Department of Dermatology and Cutaneous Surgery, and Itch Center, University of Miami Miller School of Medicine , Miami, FL, USA.
Yosipovitch G; Department of Dermatology and Cutaneous Surgery, and Itch Center, University of Miami Miller School of Medicine , Miami, FL, USA.
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Źródło :
Expert opinion on pharmacotherapy [Expert Opin Pharmacother] 2020 Sep; Vol. 21 (13), pp. 1629-1636. Date of Electronic Publication: 2020 Jun 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antipruritics/*therapeutic use
Neural Pathways/*drug effects
Pruritus/*drug therapy
Pruritus/*etiology
Sensory Receptor Cells/*drug effects
Chronic Disease ; Humans ; Pruritus/metabolism ; Quality of Life ; Sensory Receptor Cells/metabolism
Czasopismo naukowe
Tytuł :
Frataxin gene editing rescues Friedreich's ataxia pathology in dorsal root ganglia organoid-derived sensory neurons.
Autorzy :
Mazzara PG; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy.; Department of Neuroscience, The Scripps Research Institute, 92037, La Jolla, CA, USA.
Muggeo S; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy.
Luoni M; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy.
Massimino L; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy.
Zaghi M; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy.
Valverde PT; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy.
Brusco S; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy.
Marzi MJ; Center for Genomic Science of , Istituto Italiano di Tecnologia (IIT), 20139, Milan, Italy.
Palma C; Department of Electronics, Information & Bioengineering, Politecnico di Milano, 20133, Milan, Italy.
Colasante G; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy.
Iannielli A; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy.; National Research Council (CNR), Institute of Neuroscience, 20129, Milan, Italy.
Paulis M; Humanitas Clinical and Research Center, 20089, Rozzano, Milano, Italy.
Cordiglieri C; National Institute of Molecular Genetics 'Romeo e Enrica Invernizzi' - INGM, 20122, Milan, Italy.
Giannelli SG; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy.
Podini P; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy.
Gellera C; Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133, Milan, Italy.
Taroni F; Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133, Milan, Italy.
Nicassio F; Center for Genomic Science of , Istituto Italiano di Tecnologia (IIT), 20139, Milan, Italy.
Rasponi M; Department of Electronics, Information & Bioengineering, Politecnico di Milano, 20133, Milan, Italy.
Broccoli V; Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy. .; National Research Council (CNR), Institute of Neuroscience, 20129, Milan, Italy. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 21; Vol. 11 (1), pp. 4178. Date of Electronic Publication: 2020 Aug 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Friedreich Ataxia/*genetics
Friedreich Ataxia/*pathology
Ganglia, Spinal/*metabolism
Gene Editing/*methods
Iron-Binding Proteins/*genetics
Organoids/*metabolism
Sensory Receptor Cells/*metabolism
Antioxidants/pharmacology ; CRISPR-Cas Systems ; Cell Differentiation ; Chromatin/metabolism ; Friedreich Ataxia/drug therapy ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/pathology ; Genetic Predisposition to Disease/genetics ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Introns ; Mitochondria/metabolism ; Organoids/drug effects ; Organoids/pathology ; Sensory Receptor Cells/pathology ; Sequence Analysis, RNA ; Transcriptome
Czasopismo naukowe
Tytuł :
Differential Regulation of the Glucocorticoid Receptor in a Rat Model of Inflammatory Pain.
Autorzy :
Ibrahim SIA; From the Department of Anesthesiology, Pain Research Center.; Graduate Program in Molecular, Cellular, and Biochemical Pharmacology.
Strong JA; From the Department of Anesthesiology, Pain Research Center.
Qualls KA; From the Department of Anesthesiology, Pain Research Center.; Graduate Program in Molecular, Cellular, and Biochemical Pharmacology.
Ulrich-Lai YM; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Zhang JM; From the Department of Anesthesiology, Pain Research Center.
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Źródło :
Anesthesia and analgesia [Anesth Analg] 2020 Jul; Vol. 131 (1), pp. 298-306.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Disease Models, Animal*
Hyperalgesia/*metabolism
Receptors, Glucocorticoid/*metabolism
Sensory Receptor Cells/*metabolism
Animals ; Female ; Freund's Adjuvant/toxicity ; Hyperalgesia/chemically induced ; Inflammation/chemically induced ; Inflammation/metabolism ; Male ; Rats ; Rats, Sprague-Dawley ; Sensory Receptor Cells/drug effects
Czasopismo naukowe
Tytuł :
Itch: A Paradigm of Neuroimmune Crosstalk.
Autorzy :
Wang F; Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
Kim BS; Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: .
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Źródło :
Immunity [Immunity] 2020 May 19; Vol. 52 (5), pp. 753-766.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Ganglia, Spinal/*immunology
Pruritus/*immunology
Sensory Receptor Cells/*immunology
Skin/*immunology
Somatosensory Cortex/*immunology
Animals ; Ganglia, Spinal/cytology ; Ganglia, Spinal/metabolism ; Humans ; Models, Immunological ; Models, Neurological ; Pruritus/diagnosis ; Pruritus/physiopathology ; Sensory Receptor Cells/metabolism ; Sensory Receptor Cells/physiology ; Signal Transduction/immunology ; Signal Transduction/physiology ; Skin/innervation ; Somatosensory Cortex/physiopathology
Czasopismo naukowe
Tytuł :
Activation of a nerve injury transcriptional signature in airway-innervating sensory neurons after lipopolysaccharide-induced lung inflammation.
Autorzy :
Kaelberer MM; Department of Medicine, Duke University School of Medicine, Durham, North Carolina.
Caceres AI; Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina.
Jordt SE; Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina.; Department of Pharmacology and Cancer Biology, Duke University School of Medicine. Durham, North Carolina.; Integrated Toxicology and Environmental Health Program (ITEHP), Duke University, Durham, North Carolina.
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Źródło :
American journal of physiology. Lung cellular and molecular physiology 2020 May 01; Vol. 318 (5), pp. L953-L964. Date of Electronic Publication: 2020 Mar 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Transcriptome*
Nodose Ganglion/*drug effects
Pneumonia/*genetics
Receptor, Cholecystokinin B/*genetics
Sensory Receptor Cells/*drug effects
Vagus Nerve Injuries/*genetics
Animals ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/immunology ; Ganglia, Spinal/pathology ; Gene Expression Profiling ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/immunology ; Lipopolysaccharides/pharmacology ; Lung/drug effects ; Lung/immunology ; Lung/pathology ; Membrane Proteins/genetics ; Membrane Proteins/immunology ; Mice ; Mice, Inbred C57BL ; Nodose Ganglion/immunology ; Nodose Ganglion/pathology ; Peptide Hormones/genetics ; Peptide Hormones/immunology ; Pneumonia/chemically induced ; Pneumonia/immunology ; Pneumonia/pathology ; Receptor, Cholecystokinin B/immunology ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/immunology ; Sensory Receptor Cells/immunology ; Sensory Receptor Cells/pathology ; Sequence Analysis, RNA ; Trigeminal Ganglion/drug effects ; Trigeminal Ganglion/immunology ; Trigeminal Ganglion/pathology ; Vagus Nerve Injuries/chemically induced ; Vagus Nerve Injuries/immunology ; Vagus Nerve Injuries/pathology
Czasopismo naukowe
Tytuł :
Altered sensory system activity and connectivity patterns in adductor spasmodic dysphonia.
Autorzy :
Mantel T; Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse, 22, Munich, Germany.
Dresel C; Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse, 22, Munich, Germany.; Department of Neurology, Johannes Gutenberg University, Langenbeckstrasse, 1, Mainz, Germany.
Welte M; Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse, 22, Munich, Germany.
Meindl T; Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse, 22, Munich, Germany.
Jochim A; Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse, 22, Munich, Germany.
Zimmer C; Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse, 22, Munich, Germany.
Haslinger B; Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse, 22, Munich, Germany. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jun 23; Vol. 10 (1), pp. 10179. Date of Electronic Publication: 2020 Jun 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dysphonia/*physiopathology
Dystonic Disorders/*physiopathology
Sensory Receptor Cells/*physiology
Botulinum Toxins, Type A/therapeutic use ; Brain Mapping/methods ; Dysphonia/drug therapy ; Dystonic Disorders/drug therapy ; Female ; Hand/physiopathology ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Motor Cortex/drug effects ; Motor Cortex/physiopathology ; Phonation/drug effects ; Phonation/physiology ; Sensory Receptor Cells/drug effects ; Speech/drug effects ; Speech/physiology
Czasopismo naukowe
Tytuł :
Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility.
Autorzy :
Spencer NJ; College of Medicine and Public Health & Centre for Neuroscience, Flinders University, Adelaide, Australia. .
Hu H; Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine, St Louis, MO, USA.
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Źródło :
Nature reviews. Gastroenterology & hepatology [Nat Rev Gastroenterol Hepatol] 2020 Jun; Vol. 17 (6), pp. 338-351. Date of Electronic Publication: 2020 Mar 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Enteric Nervous System/*physiology
Gastrointestinal Motility/*physiology
Sensation/*physiology
Sensory Receptor Cells/*physiology
Afferent Pathways/physiology ; Autonomic Fibers, Preganglionic/physiology ; Efferent Pathways/physiology ; Enteric Nervous System/metabolism ; Enteroendocrine Cells/metabolism ; Enteroendocrine Cells/physiology ; Humans ; Mechanotransduction, Cellular/physiology ; Myoelectric Complex, Migrating/physiology ; Neural Pathways/physiology ; Neurons/metabolism ; Neurons/physiology ; Neurotransmitter Agents/metabolism ; Sensory Receptor Cells/metabolism ; Serotonin/metabolism
Czasopismo naukowe
Tytuł :
Toward Understanding Microbiome-Neuronal Signaling.
Autorzy :
Jameson KG; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: .
Olson CA; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Kazmi SA; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Hsiao EY; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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Źródło :
Molecular cell [Mol Cell] 2020 May 21; Vol. 78 (4), pp. 577-583. Date of Electronic Publication: 2020 Apr 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Gastrointestinal Microbiome*
Brain/*microbiology
Gastrointestinal Tract/*microbiology
Neurotransmitter Agents/*metabolism
Sensory Receptor Cells/*microbiology
Brain/metabolism ; Gastrointestinal Tract/metabolism ; Host-Pathogen Interactions ; Humans ; Sensory Receptor Cells/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Sensory nerve-deficient microenvironment impairs tooth homeostasis by inducing apoptosis of dental pulp stem cells.
Autorzy :
Liu AQ; State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, China.; Xi'an Institute of Tissue Engineering and Regenerative Medicine, Xi'an, China.; Department of Orthodontic Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
Zhang LS; State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, China.; Xi'an Institute of Tissue Engineering and Regenerative Medicine, Xi'an, China.; Department of Orthodontic Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
Fei DD; State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, China.; Xi'an Institute of Tissue Engineering and Regenerative Medicine, Xi'an, China.; Department of Periodontic Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
Guo H; State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, China.; Xi'an Institute of Tissue Engineering and Regenerative Medicine, Xi'an, China.; Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
Wu ML; State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, China.; Xi'an Institute of Tissue Engineering and Regenerative Medicine, Xi'an, China.; Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
Liu J; State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, China.; Xi'an Institute of Tissue Engineering and Regenerative Medicine, Xi'an, China.
He XN; State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, China.; Xi'an Institute of Tissue Engineering and Regenerative Medicine, Xi'an, China.
Zhang YJ; Xi'an Institute of Tissue Engineering and Regenerative Medicine, Xi'an, China.
Xuan K; Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
Li B; State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, China.; Xi'an Institute of Tissue Engineering and Regenerative Medicine, Xi'an, China.
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Źródło :
Cell proliferation [Cell Prolif] 2020 May; Vol. 53 (5), pp. e12803. Date of Electronic Publication: 2020 Apr 04.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*physiology
Dental Pulp/*physiology
Homeostasis/*physiology
Sensory Receptor Cells/*physiology
Stem Cells/*physiology
Tooth/*physiology
Animals ; Cell Differentiation/physiology ; Cell Proliferation/physiology ; Cells, Cultured ; Cellular Microenvironment/physiology ; Coculture Techniques/methods ; Dental Pulp/metabolism ; Dentin/metabolism ; Dentin/physiology ; Female ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cells/physiology ; Rats ; Rats, Sprague-Dawley ; Sensory Receptor Cells/metabolism ; Signal Transduction/physiology ; Stem Cells/metabolism ; Tooth/metabolism
Czasopismo naukowe
Tytuł :
Aldosterone Synthase in Peripheral Sensory Neurons Contributes to Mechanical Hypersensitivity during Local Inflammation in Rats.
Autorzy :
Mohamed DM; From the Department of Anaesthesiology and Intensive Care Medicine, Charite Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, Germany (D.M.M., M. Shaqura, X.L., S.T., M. Schäfer, S.A.M.) Department of Zoology, Faculty of Science, Aswan University, Aswan, Egypt (D.M.M.) the Departments of Anatomy (M. Shakibaei) Anaesthesiology (A.B.), Ludwig Maximilian University of Munich, Munich, Germany.
Shaqura M
Li X
Shakibaei M
Beyer A
Treskatsch S
Schäfer M
Mousa SA
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Źródło :
Anesthesiology [Anesthesiology] 2020 Apr; Vol. 132 (4), pp. 867-880.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytochrome P-450 CYP11B2/*biosynthesis
Hyperalgesia/*metabolism
Pain Measurement/*methods
Sensory Receptor Cells/*metabolism
Adjuvants, Immunologic/toxicity ; Aldosterone/biosynthesis ; Animals ; Freund's Adjuvant/toxicity ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/metabolism ; Hyperalgesia/chemically induced ; Hyperalgesia/drug therapy ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/metabolism ; Male ; Mineralocorticoid Receptor Antagonists/pharmacology ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Pain Measurement/drug effects ; Physical Stimulation/adverse effects ; Rats ; Rats, Wistar ; Sensory Receptor Cells/drug effects
Czasopismo naukowe
Tytuł :
Enhancement by TNF-α of TTX-resistant Na V current in muscle sensory neurons after femoral artery occlusion.
Autorzy :
Li Q; Heart and Vascular Institute, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Qin L; Heart and Vascular Institute, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Li J; Heart and Vascular Institute, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
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Źródło :
American journal of physiology. Regulatory, integrative and comparative physiology 2020 Apr 01; Vol. 318 (4), pp. R772-R780. Date of Electronic Publication: 2020 Feb 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Hindlimb/*innervation
Muscle, Skeletal/*innervation
NAV1.8 Voltage-Gated Sodium Channel/*metabolism
Sensory Receptor Cells/*drug effects
Tetrodotoxin/*pharmacology
Tumor Necrosis Factor-alpha/*metabolism
Animals ; Femoral Artery ; Gene Expression Regulation/drug effects ; Male ; NAV1.8 Voltage-Gated Sodium Channel/genetics ; Rats ; Rats, Sprague-Dawley ; Sensory Receptor Cells/physiology ; Sodium Channels
Czasopismo naukowe
Tytuł :
An integrative approach to the facile functional classification of dorsal root ganglion neuronal subclasses.
Autorzy :
Giacobassi MJ; School of Biological Sciences, University of Utah, Salt Lake City, UT 841120.
Leavitt LS; School of Biological Sciences, University of Utah, Salt Lake City, UT 841120.
Raghuraman S; School of Biological Sciences, University of Utah, Salt Lake City, UT 841120.
Alluri R; School of Biological Sciences, University of Utah, Salt Lake City, UT 841120.
Chase K; School of Biological Sciences, University of Utah, Salt Lake City, UT 841120.
Finol-Urdaneta RK; Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia.
Terlau H; Institute of Physiology, Christian Albrechts University Kiel, Kiel 24118, Germany.
Teichert RW; School of Biological Sciences, University of Utah, Salt Lake City, UT 841120.
Olivera BM; School of Biological Sciences, University of Utah, Salt Lake City, UT 841120; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 10; Vol. 117 (10), pp. 5494-5501. Date of Electronic Publication: 2020 Feb 20.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Ganglia, Spinal/*cytology
Sensory Receptor Cells/*classification
Sensory Receptor Cells/*physiology
Animals ; Calcium/metabolism ; Conotoxins/pharmacology ; Cytosol/metabolism ; Ganglia, Spinal/drug effects ; Kv1.1 Potassium Channel/antagonists & inhibitors ; Mice ; Mice, Transgenic ; Peptides/pharmacology ; Potassium Channel Blockers/pharmacology ; Sensory Receptor Cells/drug effects ; Single-Cell Analysis ; Transcriptome
Czasopismo naukowe
Tytuł :
Sensory neuron-derived Na V 1.7 contributes to dorsal horn neuron excitability.
Autorzy :
Alles SRA; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.
Nascimento F; Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
Luján R; Synaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Department Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, C/Almansa 14, 02008 Albacete, Spain.
Luiz AP; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.
Millet Q; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.
Bangash MA; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.
Santana-Varela S; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.
Zhou X; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.; Department of Anesthesiology, The First Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Cox JJ; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.
Okorokov AL; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.
Beato M; Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
Zhao J; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.
Wood JN; Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.
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Źródło :
Science advances [Sci Adv] 2020 Feb 19; Vol. 6 (8), pp. eaax4568. Date of Electronic Publication: 2020 Feb 19 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
NAV1.7 Voltage-Gated Sodium Channel/*genetics
Posterior Horn Cells/*physiology
Sensory Receptor Cells/*physiology
Animals ; Electrophysiological Phenomena ; Excitatory Postsynaptic Potentials ; Gene Expression ; Immunohistochemistry ; Mice ; Mice, Knockout ; NAV1.7 Voltage-Gated Sodium Channel/metabolism ; Posterior Horn Cells/drug effects ; Posterior Horn Cells/ultrastructure ; Sensory Receptor Cells/drug effects ; Sensory Receptor Cells/ultrastructure ; Voltage-Gated Sodium Channel Blockers/pharmacology
Czasopismo naukowe
Tytuł :
Characterization in Dual Activation by Oxaliplatin, a Platinum-Based Chemotherapeutic Agent of Hyperpolarization-Activated Cation and Electroporation-Induced Currents.
Autorzy :
Chang WT; Division of Cardiovascular Medicine, Chi-Mei Medical Center, Tainan 71004, Taiwan.; Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71004, Taiwan.; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Gao ZH; Department of Physiology, National Cheng Kung University Medical College, Tainan 70101, Taiwan.
Li SW; Department of Physiology, National Cheng Kung University Medical College, Tainan 70101, Taiwan.
Liu PY; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.; Division of Cardiovascular Medicine, Internal Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan 70401, Taiwan.
Lo YC; Department of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Wu SN; Department of Physiology, National Cheng Kung University Medical College, Tainan 70101, Taiwan.; Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan 70101, Taiwan.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jan 08; Vol. 21 (2). Date of Electronic Publication: 2020 Jan 08.
Typ publikacji :
Journal Article
MeSH Terms :
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/*genetics
Neuroendocrine Cells/*drug effects
Oxaliplatin/*adverse effects
Sensory Receptor Cells/*drug effects
Animals ; Cations/pharmacology ; Electroporation ; Humans ; Mice ; Neoplasms/complications ; Neoplasms/drug therapy ; Oxaliplatin/pharmacology ; Sensory Receptor Cells/metabolism ; Sensory Receptor Cells/pathology
Czasopismo naukowe
Tytuł :
Targeted thermal stimulation and high-content phenotyping reveal that the C. elegans escape response integrates current behavioral state and past experience.
Autorzy :
Byrne Rodgers J; Department of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada.; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Ryu WS; Department of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada.; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.; Department of Physics, University of Toronto, Toronto, Ontario, Canada.
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Źródło :
PloS one [PLoS One] 2020 Mar 27; Vol. 15 (3), pp. e0229399. Date of Electronic Publication: 2020 Mar 27 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Hot Temperature*
Avoidance Learning/*physiology
Behavior, Animal/*physiology
Caenorhabditis elegans/*physiology
Escape Reaction/*physiology
Sensory Receptor Cells/*metabolism
Thermosensing/*physiology
Animals ; Phenotype ; Sensory Receptor Cells/cytology
Czasopismo naukowe

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