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Tytuł :
Influence of innate immune activation on endocrine and metabolic pathways in infancy.
Autorzy :
O'Connor KM; Department of Physiology, School of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland.
Ashoori M; Department of Physiology, School of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland.; Irish Centre for Maternal and Child Health Research (INFANT), University College Cork, Cork, Ireland.
Dias ML; Department of Physiology, School of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland.
Dempsey EM; Irish Centre for Maternal and Child Health Research (INFANT), University College Cork, Cork, Ireland.; Department of Paediatrics and Child Health, School of Medicine, College of Medicine and Health, Cork University Hospital, Wilton, Cork, Ireland.
O'Halloran KD; Department of Physiology, School of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland.; Irish Centre for Maternal and Child Health Research (INFANT), University College Cork, Cork, Ireland.
McDonald FB; Department of Physiology, School of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland.; Irish Centre for Maternal and Child Health Research (INFANT), University College Cork, Cork, Ireland.
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Źródło :
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2021 Jul 01; Vol. 321 (1), pp. E24-E46. Date of Electronic Publication: 2021 Apr 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Endocrine System*
Infant, Premature*
Metabolic Networks and Pathways*
Neonatal Sepsis*
Immunity, Innate/*physiology
Animals ; Biomarkers ; Gonads ; Humans ; Hydrocortisone/blood ; Hypothalamo-Hypophyseal System ; Infant, Newborn ; Neurosecretory Systems ; Sepsis ; Thyroid Gland
Czasopismo naukowe
Tytuł :
Deficiency of cGAS signaling protects against sepsis-associated encephalopathy.
Autorzy :
Tan C; Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410000, PR China.
Xu F; Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, 410000, PR China.
Xie Q; Department of Cardiology, People's Hospital of Hunan Province, Changsha, 410000, PR China.
Li F; Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410000, PR China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Nov 05; Vol. 577, pp. 38-44. Date of Electronic Publication: 2021 Sep 03.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Nucleotidyltransferases/*genetics
Sepsis-Associated Encephalopathy/*genetics
Signal Transduction/*genetics
Animals ; Animals, Newborn ; Astrocytes/metabolism ; Cognitive Dysfunction/genetics ; Cognitive Dysfunction/metabolism ; Cognitive Dysfunction/physiopathology ; Hippocampus/drug effects ; Hippocampus/metabolism ; Humans ; Interferon Type I/metabolism ; Male ; Maze Learning/physiology ; Mice, Inbred C57BL ; Mice, Knockout ; Microglia/metabolism ; Neurons/metabolism ; Nucleotidyltransferases/deficiency ; Protective Agents/metabolism ; Sepsis/genetics ; Sepsis/metabolism ; Sepsis/physiopathology ; Sepsis-Associated Encephalopathy/metabolism
Czasopismo naukowe
Tytuł :
S100B/RAGE/Ceramide signaling pathway is involved in sepsis-associated encephalopathy.
Autorzy :
Zhang L; Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: .
Jiang Y; Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Deng S; Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: .
Mo Y; Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: .
Huang Y; Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: .
Li W; Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: .
Ge C; Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: .
Ren X; Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: .
Zhang H; Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: .
Zhang X; Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: .
Peng Q; Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: .
Liu Z; Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: .
Huang L; Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: .
Zhou F; Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha 410011, China. Electronic address: .
Ai Y; Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jul 15; Vol. 277, pp. 119490. Date of Electronic Publication: 2021 Apr 13.
Typ publikacji :
Journal Article
MeSH Terms :
Ceramides/*metabolism
Receptor for Advanced Glycation End Products/*metabolism
S100 Calcium Binding Protein beta Subunit/*metabolism
Sepsis-Associated Encephalopathy/*metabolism
Animals ; Apoptosis/drug effects ; Brain/metabolism ; Brain Diseases/complications ; Brain Diseases/metabolism ; Brain Injuries/metabolism ; Cognitive Dysfunction/metabolism ; Disease Models, Animal ; Hippocampus/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Neurons/metabolism ; Sepsis/complications ; Sepsis-Associated Encephalopathy/complications ; Sepsis-Associated Encephalopathy/physiopathology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Evaluation of Implementation of Early-Onset Sepsis Calculator in Newborns in Israel.
Autorzy :
Riskin A; Department of Neonatology, Bnai Zion Medical Center, Haifa, Israel; Ruth & Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel. Electronic address: .
Bryskin S; Department of Pediatrics, Bnai Zion Medical Center, Haifa, Israel.
Zaitoon H; Department of Pediatrics, Bnai Zion Medical Center, Haifa, Israel.
Toropine A; Department of Neonatology, Bnai Zion Medical Center, Haifa, Israel.
Iofe A; Department of Neonatology, Bnai Zion Medical Center, Haifa, Israel.
Zoabi-Safadi R; Department of Neonatology, Bnai Zion Medical Center, Haifa, Israel.
Bader D; Department of Neonatology, Bnai Zion Medical Center, Haifa, Israel; Ruth & Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
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Źródło :
The Journal of pediatrics [J Pediatr] 2021 Jul; Vol. 234, pp. 71-76.e2. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Decision Support Techniques*
Neonatal Sepsis/*diagnosis
Delivery, Obstetric/statistics & numerical data ; Female ; Humans ; Infant, Newborn ; Israel/epidemiology ; Neonatal Sepsis/epidemiology ; Practice Guidelines as Topic ; Pregnancy ; Prospective Studies ; Risk Factors ; Sepsis
Czasopismo naukowe
Tytuł :
Sepsis.
Autorzy :
Ackerman MH; Masters in Healthcare Innovation Program, The Ohio State University, Columbus, OH, USA. Electronic address: .
Ahrens T; Viven Health, 006 Woodbridge Creek Court, St Louis, MO 63129, USA.
Kelly J; OSU Wexner Medical Center - The James, 460 West 10th Avenue, Room C1138, Columbus, OH, 43210, USA.
Pontillo A; Nursing Education Department, James Cancer Hospital Solove Research Institute, 660 Ackerman Road, 5th Floor/Room 574, Columbus, OH 43202, USA.
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Źródło :
Critical care nursing clinics of North America [Crit Care Nurs Clin North Am] 2021 Dec; Vol. 33 (4), pp. 407-418. Date of Electronic Publication: 2021 Oct 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Organ Dysfunction Scores*
Sepsis*/diagnosis
Sepsis*/therapy
Humans ; Prognosis
Czasopismo naukowe
Tytuł :
Evaluation of serum and salivary C-reactive protein for diagnosis of late-onset neonatal sepsis: A single center cross-sectional study.
Autorzy :
Tosson AMS; Cairo University, Faculty of Medicine, Department of Pediatrics, Cairo, Egypt. Electronic address: .
Koptan D; Cairo University, Faculty of Medicine, Clinical and Chemical Pathology Department, Cairo, Egypt.
Abdel Aal R; Cairo University, Faculty of Medicine, Department of Pediatrics, Cairo, Egypt.
Abd Elhady M; Cairo University, Faculty of Medicine, Department of Pediatrics, Cairo, Egypt.
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Źródło :
Jornal de pediatria [J Pediatr (Rio J)] 2021 Nov-Dec; Vol. 97 (6), pp. 623-628. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article
MeSH Terms :
Neonatal Sepsis*/diagnosis
Sepsis*/diagnosis
Biomarkers ; C-Reactive Protein/analysis ; Cross-Sectional Studies ; Humans ; Infant, Newborn ; Predictive Value of Tests ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
Neonatal sepsis in Sana'a city, Yemen: a predominance of Burkholderia cepacia.
Autorzy :
Salah A; Department of Pathology, Faculty of Medicine and Health Sciences, University of Science and Technology, Sanaa, Yemen. .
Al-Subol I; Department of Microbiology, Faculty of Medicine and Health Sciences, University of Science and Technology, Sanaa, Yemen.
Hudna A; Department of Pediatrics, Faculty of Medicine and Health Sciences, University of Science and Technology, Sanaa, Yemen.
Alhaj A; Department of Biochemistry, Faculty of Medicine and Health Sciences, University of Science and Technology, Sanaa, Yemen.
Alqubaty AR; Department of Biochemistry, Faculty of Medicine and Health Sciences, University of Science and Technology, Sanaa, Yemen.
Farie W; Department of Laboratory Medicine, Faculty of Medicine and Health Sciences, University of Science and Technology, Sanaa, Yemen.
Sulieman D; Department of Laboratory Medicine, Faculty of Medicine and Health Sciences, University of Science and Technology, Sanaa, Yemen.
Alnadhari O; Department of Pediatrics, C-PLAS Hospital, Sanaa, Yemen.
Alwajeeh T; Department of Laboratory Medicine, Faculty of Medicine and Health Sciences, University of Amran, Amran, Yemen.
Alobathani F; Department of Pediatrics, Al-Kuwait University Hospital, Sanaa, Yemen.
Almikhlafy A; Department of Community Medicine, Faculty of Medicine and Health Sciences, University of Science and Technology, Sanaa, Yemen.
Mahdy MAK; Department of Parasitology, Faculty of Medicine, University of Sana'a, Sanaa, Yemen.; Tropical Disease Research Center, University of Science and Technology, Sanaa, Yemen.
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Źródło :
BMC infectious diseases [BMC Infect Dis] 2021 Oct 27; Vol. 21 (1), pp. 1108. Date of Electronic Publication: 2021 Oct 27.
Typ publikacji :
Journal Article
MeSH Terms :
Burkholderia cepacia*
Neonatal Sepsis*/drug therapy
Neonatal Sepsis*/epidemiology
Sepsis*/drug therapy
Sepsis*/epidemiology
Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cross-Sectional Studies ; Female ; Humans ; Infant, Newborn ; Intensive Care Units, Neonatal ; Microbial Sensitivity Tests ; Pregnancy ; Yemen/epidemiology
Czasopismo naukowe
Tytuł :
Knowledge translation following the implementation of a state-wide Paediatric Sepsis Pathway in the emergency department- a multi-centre survey study.
Autorzy :
Harley A; School of Nursing, Midwifery and Social Work, The University of Queensland, Brisbane, QLD, Australia. .; Child Health Research Centre, The University of Queensland, and Paediatric Intensive Care Unit, Queensland Children's Hospital, QLD, Brisbane, Australia. .; Department of Emergency Medicine, Gold Coast University Hospital, Gold Coast, QLD, Australia. .
Schlapbach LJ; Child Health Research Centre, The University of Queensland, and Paediatric Intensive Care Unit, Queensland Children's Hospital, QLD, Brisbane, Australia.; Pediatric and Neonatal Intensive Care Unit, Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Lister P; Paediatric Intensive Care Unit, Sunshine Coast University Hospital, Sunshine Coast, QLD, Australia.; School of Medicine, Griffith University, Brisbane, QLD, Australia.
Massey D; School of Nursing and Midwifery, Southern Cross University, Gold Coast, QLD, Australia.
Gilholm P; Child Health Research Centre, The University of Queensland, and Paediatric Intensive Care Unit, Queensland Children's Hospital, QLD, Brisbane, Australia.
Johnston ANB; School of Nursing, Midwifery and Social Work, The University of Queensland, Brisbane, QLD, Australia.; Department of Emergency Medicine, Princess Alexandra Hospital, Brisbane, QLD, Australia.
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Źródło :
BMC health services research [BMC Health Serv Res] 2021 Oct 26; Vol. 21 (1), pp. 1161. Date of Electronic Publication: 2021 Oct 26.
Typ publikacji :
Journal Article; Multicenter Study; Observational Study
MeSH Terms :
Patient Care Bundles*
Sepsis*/diagnosis
Sepsis*/therapy
Child ; Cross-Sectional Studies ; Emergency Service, Hospital ; Humans ; Translational Medical Research
Czasopismo naukowe
Tytuł :
Neonatal sepsis at point of care.
Autorzy :
Jyoti A; Amity Institute of Biotechnology, Amity University, Jaipur, Rajasthan 303002, India; Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Bajhol, Solan, Himachal Pradesh, 173229, India. Electronic address: .
Kumar S; Department of Electrical Engineering, Indian Institute of Technology, Hyderabad, Telangana 502285, India. Electronic address: .
Kumar Srivastava V; Amity Institute of Biotechnology, Amity University, Jaipur, Rajasthan 303002, India. Electronic address: .
Kaushik S; Amity Institute of Biotechnology, Amity University, Jaipur, Rajasthan 303002, India. Electronic address: .
Govind Singh S; Department of Electrical Engineering, Indian Institute of Technology, Hyderabad, Telangana 502285, India. Electronic address: .
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Źródło :
Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2021 Oct; Vol. 521, pp. 45-58. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Neonatal Sepsis*/diagnosis
Sepsis*/diagnosis
Biomarkers ; Early Diagnosis ; Humans ; Infant, Newborn ; Point-of-Care Systems
Czasopismo naukowe
Tytuł :
The Accuracy of 16S rRNA Polymerase Chain Reaction for the Diagnosis of Neonatal Sepsis: A Meta-Analysis.
Autorzy :
Wang Y; Department of Pharmacy, The Affiliated Hospital of Chengde Medical College, Chengde 067000, China.
Zhao J; Department of Functional Center, Chengde Medical College, Chengde 067000, China.
Yao Y; Department of Pharmacy, The Affiliated Hospital of Chengde Medical College, Chengde 067000, China.
Yang L; Institute of Chinese Materia Medica, Chengde Medical College, Chengde 067000, China.
Zhao D; Department of Intensive Care Unit, The Affiliated Hospital of Chengde Medical College, Chengde 067000, China.
Liu S; Department of Thoracic Surgery, The Affiliated Hospital of Chengde Medical College, Chengde 067000, China.
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Źródło :
BioMed research international [Biomed Res Int] 2021 May 12; Vol. 2021, pp. 5550387. Date of Electronic Publication: 2021 May 12 (Print Publication: 2021).
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Neonatal Sepsis/*diagnosis
RNA, Ribosomal, 16S/*genetics
Area Under Curve ; Bacteria/genetics ; Biomarkers/blood ; Data Accuracy ; Humans ; Infant, Newborn ; Neonatal Sepsis/genetics ; Neonatal Sepsis/microbiology ; Odds Ratio ; Polymerase Chain Reaction/methods ; ROC Curve ; Sensitivity and Specificity ; Sepsis/diagnosis
Czasopismo naukowe
Tytuł :
Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Autorzy :
Beck C; Pennsylvania State University, University Park, Pennsylvania; and Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Gallagher K
Taylor LA
Goldstein JA
Mithal LB
Gernand AD
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Źródło :
Obstetrics and gynecology [Obstet Gynecol] 2021 Jun 01; Vol. 137 (6), pp. 1007-1022.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Systematic Review
MeSH Terms :
Chorioamnionitis/*epidemiology
Chorioamnionitis/*pathology
Neonatal Sepsis/*epidemiology
Premature Birth/*epidemiology
Female ; Gestational Age ; Humans ; Incidence ; Infant, Newborn ; Postpartum Period ; Pregnancy ; Sepsis/epidemiology ; Term Birth ; Time Factors
Czasopismo naukowe
Tytuł :
An observational cohort study of the performance of the REDS score compared to the SIRS criteria, NEWS2, CURB65, SOFA, MEDS and PIRO scores to risk-stratify emergency department suspected sepsis.
Autorzy :
Sivayoham N; Department of Emergency Medicine, St George's University Hospitals NHS Foundation Trust, London, UK.
Hussain AN; Department of Emergency Medicine, St George's University Hospitals NHS Foundation Trust, London, UK.
Shabbo L; Department of Emergency Medicine, St George's University Hospitals NHS Foundation Trust, London, UK.
Christie D; Department of Emergency Medicine, St George's University Hospitals NHS Foundation Trust, London, UK.
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Źródło :
Annals of medicine [Ann Med] 2021 Dec; Vol. 53 (1), pp. 1863-1874.
Typ publikacji :
Comparative Study; Journal Article; Observational Study
MeSH Terms :
Severity of Illness Index*
Anti-Bacterial Agents/*administration & dosage
Emergency Service, Hospital/*statistics & numerical data
Intensive Care Units/*statistics & numerical data
Sepsis/*mortality
Administration, Intravenous ; Aged ; Aged, 80 and over ; Female ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; ROC Curve ; Retrospective Studies ; Risk Assessment/methods ; Sepsis/diagnosis ; Sepsis/drug therapy
Czasopismo naukowe
Tytuł :
Clinical significance of the serum miR-455-5p expression in patients with neonatal sepsis.
Autorzy :
Mao YY; Department of Pediatrics, The First People's Hospital of Yuhang, Zhejiang, Hangzhou, China.
Su C; Department of Pediatrics, The First People's Hospital of Yuhang, Zhejiang, Hangzhou, China.
Fang CC; Department of Pediatrics, The First People's Hospital of Yuhang, Zhejiang, Hangzhou, China.
Fan XP; Department of Pediatrics, The First People's Hospital of Yuhang, Zhejiang, Hangzhou, China.
Wang LP; Department of Pediatrics, The First People's Hospital of Yuhang, Zhejiang, Hangzhou, China.
Zhu SS; Department of Pediatrics, The First People's Hospital of Yuhang, Zhejiang, Hangzhou, China.
Yao HM; Department of Pediatrics, The First People's Hospital of Yuhang, Zhejiang, Hangzhou, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 4174-4182.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
MicroRNAs/*blood
MicroRNAs/*genetics
Neonatal Sepsis/*blood
Neonatal Sepsis/*genetics
Female ; Humans ; Infant, Newborn ; Kaplan-Meier Estimate ; Male ; Multivariate Analysis ; Neonatal Sepsis/diagnosis ; Prognosis ; Proportional Hazards Models ; ROC Curve
Czasopismo naukowe
Tytuł :
MAPK interacting serine/threonine kinase 1 ( MKNK1 ), one target gene of miR-223-3p, correlates with neutrophils in sepsis based on bioinformatic analysis.
Autorzy :
Fu M; Department of Intensive Care Unit, Huzhou Cent Hosp, Affiliated Cent Hosp HuZhou University, Huzhou, Zhejiang, Peoples R China.
Zhang K; Department of Emergency, Huzhou Cent Hosp, Affiliated Cent Hosp HuZhou University, Huzhou, Zhejiang, Peoples R China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 2550-2562.
Typ publikacji :
Journal Article
MeSH Terms :
Computational Biology*
Intracellular Signaling Peptides and Proteins/*genetics
MicroRNAs/*metabolism
Neutrophils/*metabolism
Protein-Serine-Threonine Kinases/*genetics
Sepsis/*genetics
Gene Expression Profiling ; Humans ; Immunity/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; MicroRNAs/genetics ; Neutrophils/immunology ; Protein Interaction Maps/genetics ; Protein-Serine-Threonine Kinases/metabolism ; ROC Curve ; Reproducibility of Results ; Sepsis/immunology ; Sepsis/pathology
Czasopismo naukowe
Tytuł :
Statistical analysis plan for the Steppedwedge Cluster Randomized trial of Electronic Early Notification of sepsis in hospitalized ward patients (SCREEN).
Autorzy :
Arabi YM; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Intensive Care Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia. .
Vishwakarma RK; Biostatistics and Bioinformatics Department, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.; Statistics Department, European Organisation for Research and Treatment of Cancer (EORTC) Headquarters, Brussels, Belgium.
Al-Dorzi HM; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Intensive Care Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
Al Qasim E; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Intensive Care Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
Abdukahil SA; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Intensive Care Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
Al-Rabeah FK; College of Health Informatics, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Information Systems and Informatics Division, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
Al Ghamdi H; College of Health Informatics, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Information Systems and Informatics Division, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
Al Ghamdi E; College of Health Informatics, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Information Systems and Informatics Division, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
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Corporate Authors :
SCREEN Trial Group
Źródło :
Trials [Trials] 2021 Nov 22; Vol. 22 (1), pp. 828. Date of Electronic Publication: 2021 Nov 22.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
COVID-19*
Sepsis*/diagnosis
Sepsis*/therapy
Electronics ; Hospitals ; Humans ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial.
Autorzy :
Weiss SL; Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. .; The Children's Hospital of Philadelphia Pediatric Sepsis Program, Philadelphia, PA, USA. .
Balamuth F; The Children's Hospital of Philadelphia Pediatric Sepsis Program, Philadelphia, PA, USA.; Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Long E; Department of Emergency Medicine, The Royal Children's Hospital, Parkville, Victoria, Australia.; Departments of Pediatrics and Critical Care, The University of Melbourne, Parkville, Victoria, Australia.; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Thompson GC; Departments of Pediatrics and Emergency Medicine, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Hayes KL; The Children's Hospital of Philadelphia Pediatric Sepsis Program, Philadelphia, PA, USA.
Katcoff H; Department of Biomedical and Health Informatics, Data Science and Biostatistics Unit, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Cook M; Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Tsemberis E; Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Hickey CP; The Children's Hospital of Philadelphia Pediatric Sepsis Program, Philadelphia, PA, USA.
Williams A; Department of Emergency Medicine, The Royal Children's Hospital, Parkville, Victoria, Australia.
Williamson-Urquhart S; Departments of Pediatrics and Emergency Medicine, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Borland ML; Divisions of Emergency Medicine and Pediatrics, Perth Children's Hospital, School of Medicine at the University of Western Australia, Crawley, Australia.
Dalziel SR; Departments of Surgery and Pediatrics: Child and Youth Health, Starship Children's Hospital, University of Auckland, Auckland, New Zealand.
Gelbart B; Departments of Pediatrics and Critical Care, The University of Melbourne, Parkville, Victoria, Australia.; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.; Australian and New Zealand Intensive Care Society Paediatric Study Group, Camberwell, Australia.; Paediatric Intensive Care Unit, Royal Children's Hospital, Parkville, Victoria, Australia.
Freedman SB; Sections of Pediatric Emergency Medicine and Gastroenterology, Departments of Pediatrics and Emergency Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Babl FE; Department of Emergency Medicine, The Royal Children's Hospital, Parkville, Victoria, Australia.; Departments of Pediatrics and Critical Care, The University of Melbourne, Parkville, Victoria, Australia.; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Huang J; Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Kuppermann N; Department of Emergency Medicine and Pediatrics, UC Davis School of medicine and UC Davis Health, Sacramento, CA, USA.
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Corporate Authors :
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis (PRoMPT BOLUS) Investigators of the PECARN, PERC, and PREDICT Networks
Źródło :
Trials [Trials] 2021 Nov 06; Vol. 22 (1), pp. 776. Date of Electronic Publication: 2021 Nov 06.
Typ publikacji :
Clinical Trial Protocol; Journal Article
MeSH Terms :
Sepsis*/diagnosis
Sepsis*/therapy
Shock, Septic*/diagnosis
Shock, Septic*/therapy
Child ; Crystalloid Solutions ; Fluid Therapy ; Humans ; Randomized Controlled Trials as Topic ; Saline Solution/adverse effects
Czasopismo naukowe
Tytuł :
Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis.
Autorzy :
Du F; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning, 110016, China.
Sun W; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning, 110016, China.
Morisseau C; Department of Entomology and Nematology and UC Davis Comprehensive Cancer Center, University of California Davis, One Shields Avenue, Davis, CA, 95616, USA.
Hammock BD; Department of Entomology and Nematology and UC Davis Comprehensive Cancer Center, University of California Davis, One Shields Avenue, Davis, CA, 95616, USA.
Bao X; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning, 110016, China; Jiangsu Kanion Pharmaceutical Co., Ltd., Jiangning Industrial City, Economic and Technological Development Zone, Lianyungang, Jiangsu, 222001, China.
Liu Q; Jiangsu Kanion Pharmaceutical Co., Ltd., Jiangning Industrial City, Economic and Technological Development Zone, Lianyungang, Jiangsu, 222001, China.
Wang C; Jiangsu Kanion Pharmaceutical Co., Ltd., Jiangning Industrial City, Economic and Technological Development Zone, Lianyungang, Jiangsu, 222001, China.
Zhang T; Jiangsu Kanion Pharmaceutical Co., Ltd., Jiangning Industrial City, Economic and Technological Development Zone, Lianyungang, Jiangsu, 222001, China.
Yang H; Jiangsu Kanion Pharmaceutical Co., Ltd., Jiangning Industrial City, Economic and Technological Development Zone, Lianyungang, Jiangsu, 222001, China.
Zhou J; Jiangsu Kanion Pharmaceutical Co., Ltd., Jiangning Industrial City, Economic and Technological Development Zone, Lianyungang, Jiangsu, 222001, China.
Xiao W; Jiangsu Kanion Pharmaceutical Co., Ltd., Jiangning Industrial City, Economic and Technological Development Zone, Lianyungang, Jiangsu, 222001, China. Electronic address: .
Liu Z; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning, 110016, China. Electronic address: .
Chen G; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning, 110016, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 05; Vol. 223, pp. 113678. Date of Electronic Publication: 2021 Jun 29.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Inhibitors/*therapeutic use
Epoxide Hydrolases/*antagonists & inhibitors
Memantine/*chemistry
Sepsis/*drug therapy
Urea/*analogs & derivatives
Animals ; Binding Sites ; Catalytic Domain ; Disease Models, Animal ; Drug Design ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/metabolism ; Epoxide Hydrolases/metabolism ; Female ; Humans ; Lipopolysaccharides/toxicity ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Docking Simulation ; Rats ; Sepsis/etiology ; Sepsis/mortality ; Structure-Activity Relationship ; Survival Rate ; Urea/metabolism ; Urea/therapeutic use
Czasopismo naukowe
Tytuł :
Maternal Obesity and Risk of Early-onset Neonatal Bacterial Sepsis: Nationwide Cohort and Sibling-controlled Studies.
Autorzy :
Villamor E; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Norman M; Department of Clinical Science, Intervention, and Technology, Division of Pediatrics, Karolinska Institutet, Stockholm, Sweden.
Johansson S; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.; Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Cnattingius S; Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
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Źródło :
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Nov 02; Vol. 73 (9), pp. e2656-e2664.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Neonatal Sepsis*/epidemiology
Neonatal Sepsis*/etiology
Obesity, Maternal*
Pregnancy Complications*
Body Mass Index ; Cesarean Section ; Cohort Studies ; Female ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Pregnancy ; Retrospective Studies ; Risk Factors ; Siblings
Czasopismo naukowe
Tytuł :
Nephroprotective effect of apilarnil in lipopolysaccharide-induced sepsis through TLR4/NF-κB signaling pathway.
Autorzy :
Inandiklioglu N; Department of Medical Biology, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkey. Electronic address: .
Doganyigit Z; Department of Histology and Embryology, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkey.
Okan A; Department of Histology and Embryology, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkey.
Kaymak E; Department of Histology and Embryology, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkey.
Silici S; Department of Agricultural Biotechnology, Faculty of Agriculture, Erciyes University, Kayseri, Turkey.
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Źródło :
Life sciences [Life Sci] 2021 Nov 01; Vol. 284, pp. 119875. Date of Electronic Publication: 2021 Aug 10.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Biological Products/*therapeutic use
Kidney/*pathology
NF-kappa B/*metabolism
Protective Agents/*pharmacology
Sepsis/*drug therapy
Toll-Like Receptor 4/*metabolism
Animals ; Biological Products/pharmacology ; Gene Expression Regulation/drug effects ; Kidney/drug effects ; Lipopolysaccharides ; Male ; Rats, Sprague-Dawley ; Sepsis/genetics ; Sepsis/pathology
Czasopismo naukowe
Tytuł :
Varying international practices regarding the evaluation of febrile young infants.
Autorzy :
Umana E; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.
Waterfield T; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK .
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Źródło :
Archives of disease in childhood [Arch Dis Child] 2021 Nov; Vol. 106 (11), pp. 1037-1038. Date of Electronic Publication: 2021 Sep 15.
Typ publikacji :
Editorial
MeSH Terms :
Bacterial Infections/*diagnosis
Fever/*diagnosis
Practice Patterns, Physicians'/*statistics & numerical data
Sepsis/*diagnosis
Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/complications ; Bacterial Infections/epidemiology ; Biomarkers/blood ; Fever/drug therapy ; Fever/epidemiology ; Hospitals, Pediatric/standards ; Humans ; Infant ; Infant, Newborn ; Ireland/epidemiology ; Meningitis, Bacterial/diagnosis ; Meningitis, Bacterial/epidemiology ; Meningitis, Bacterial/therapy ; Patient Care/methods ; Patient Care/standards ; Pediatric Emergency Medicine/standards ; Practice Patterns, Physicians'/trends ; Sepsis/epidemiology ; Sepsis/etiology ; United Kingdom/epidemiology ; Urinary Tract Infections/diagnosis ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/epidemiology
Opinia redakcyjna

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