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Wyszukujesz frazę ""Serine Endopeptidases"" wg kryterium: Temat


Tytuł :
Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements.
Autorzy :
Yang J; Department of Integrative, Structural and Computational Biology, Scripps Research, La Jolla, California, USA.
Song AS; Department of Integrative, Structural and Computational Biology, Scripps Research, La Jolla, California, USA; Department of Molecular Medicine, Scripps Research, La Jolla, California, USA.
Wiseman RL; Department of Molecular Medicine, Scripps Research, La Jolla, California, USA. Electronic address: .
Lander GC; Department of Integrative, Structural and Computational Biology, Scripps Research, La Jolla, California, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2022 Mar; Vol. 298 (3), pp. 101694. Date of Electronic Publication: 2022 Feb 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitochondrial Proteins*/chemistry
Mitochondrial Proteins*/metabolism
Protease La*/chemistry
Protease La*/metabolism
Proto-Oncogene Proteins c-pim-1*/chemistry
Proto-Oncogene Proteins c-pim-1*/metabolism
Saccharomyces cerevisiae Proteins*/chemistry
Saccharomyces cerevisiae Proteins*/genetics
Saccharomyces cerevisiae Proteins*/metabolism
Serine Endopeptidases*/chemistry
Serine Endopeptidases*/metabolism
ATP-Dependent Proteases/metabolism ; Adenosine Triphosphatases/metabolism ; Cryoelectron Microscopy ; Humans ; Peptide Hydrolases/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Enhancing fibroblast activation protein (FAP)-targeted radionuclide therapy with albumin binding, and beyond.
Autorzy :
Younis MH; Departments of Radiology and Medical Physics, University of Wisconsin - Madison, Madison, WI, USA.
Malih S; Departments of Radiology and Medical Physics, University of Wisconsin - Madison, Madison, WI, USA.; Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Lan X; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. .; Hubei Key Laboratory of Molecular Imaging, Wuhan, China. .
Rasaee MJ; Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. .
Cai W; Departments of Radiology and Medical Physics, University of Wisconsin - Madison, Madison, WI, USA. .
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Źródło :
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2022 May; Vol. 49 (6), pp. 1773-1777.
Typ publikacji :
Editorial
MeSH Terms :
Gelatinases*/metabolism
Serine Endopeptidases*/metabolism
Albumins/therapeutic use ; Fibroblasts/metabolism ; Humans ; Radioisotopes/therapeutic use
Opinia redakcyjna
Tytuł :
Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity.
Autorzy :
Essalmani R; Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.
Jain J; Laboratory of Human Retrovirology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.
Susan-Resiga D; Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.
Andréo U; Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.; Laboratory of Human Retrovirology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.
Evagelidis A; Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.
Derbali RM; Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.
Huynh DN; Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.
Dallaire F; Laboratory of Human Retrovirology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.
Laporte M; Laboratory of Human Retrovirology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.
Delpal A; AFMB, CNRS, Aix-Marseille University, CNRS, UMR 7257, Case 925, Marseille, France.
Sutto-Ortiz P; AFMB, CNRS, Aix-Marseille University, CNRS, UMR 7257, Case 925, Marseille, France.
Coutard B; Unité des Virus Émergents (UVE), Aix-Marseille University, IRD 190, INSERM 1207, IHU Méditerranée Infection, Marseille, France.
Mapa C; Boston Pharmaceuticals, Translational Research, Cambridge, Massachusetts, USA.
Wilcoxen K; Boston Pharmaceuticals, Translational Research, Cambridge, Massachusetts, USA.
Decroly E; AFMB, CNRS, Aix-Marseille University, CNRS, UMR 7257, Case 925, Marseille, France.
Nq Pham T; Laboratory of Human Retrovirology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.
Cohen ÉA; Laboratory of Human Retrovirology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.; Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Quebec, Canada.
Seidah NG; Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.
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Źródło :
Journal of virology [J Virol] 2022 Apr 27; Vol. 96 (8), pp. e0012822. Date of Electronic Publication: 2022 Mar 28.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19*/pathology
COVID-19*/virology
Furin*/metabolism
SARS-CoV-2*/genetics
SARS-CoV-2*/pathogenicity
Serine Endopeptidases*/metabolism
Angiotensin-Converting Enzyme 2/metabolism ; Animals ; HeLa Cells ; Humans ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Internalization
Czasopismo naukowe
Tytuł :
Novel Insights Into Leishmania (Viannia) braziliensis In Vitro Fitness Guided by Temperature Changes Along With Its Subtilisins and Oligopeptidase B.
Autorzy :
Zabala-Peñafiel A; Laboratório de Biologia Molecular e Doenças Endêmicas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Cysne-Finkelstein L; Laboratório de Imunoparasitologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Conceição-Silva F; Laboratório de Imunoparasitologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Fagundes A; Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Miranda LFC; Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Souza-Silva F; Centro de Desenvolvimento Tecnológico em Saúde, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.; Universidade Iguaçu, Dom Rodrigo, Nova Iguaçu, Rio de Janeiro, Brazil.
Brandt AAML; Departamento de Computação e Sistemas, Faculdade de Educação Tecnológica do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.; Departamento de Ciência da Computação, Univeritas-Rio, Rio de Janeiro, Brazil.
Dias-Lopes G; Laboratório de Biologia Molecular e Doenças Endêmicas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Alves CR; Laboratório de Biologia Molecular e Doenças Endêmicas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
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Źródło :
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Apr 21; Vol. 12, pp. 805106. Date of Electronic Publication: 2022 Apr 21 (Print Publication: 2022).
Typ publikacji :
Journal Article
MeSH Terms :
Leishmania braziliensis*/enzymology
Serine Endopeptidases*/metabolism
Subtilisin*
Temperature*
Animals ; Life Cycle Stages ; Mice ; RNA, Messenger
Czasopismo naukowe
Tytuł :
Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry.
Autorzy :
Bagga T; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, 117543, Singapore.
Tulsian NK; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, 117543, Singapore. .; Department of Biochemistry, National University of Singapore, 28 Medical Drive, Singapore, 117546, Singapore. .
Mok YK; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, 117543, Singapore.
Kini RM; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, 117543, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 16 Medical Drive, Singapore, 117600, Singapore.; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, 1101 E Marshall Street, Richmond, VA, 23298, USA.
Sivaraman J; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, 117543, Singapore. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2022 Apr 10; Vol. 79 (5), pp. 233. Date of Electronic Publication: 2022 Apr 10.
Typ publikacji :
Journal Article
MeSH Terms :
Dengue Virus*/physiology
Serine Endopeptidases*/chemistry
Tripartite Motif Proteins*/chemistry
Ubiquitin-Protein Ligases*/chemistry
Viral Nonstructural Proteins*/chemistry
Dengue ; Deuterium Exchange Measurement ; Humans ; Mass Spectrometry
Czasopismo naukowe
Tytuł :
SMYD2 Inhibition Downregulates TMPRSS2 and Decreases SARS-CoV-2 Infection in Human Intestinal and Airway Epithelial Cells.
Autorzy :
Yu YQ; Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91052 Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), 91052 Erlangen, Germany.; Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.
Herrmann A; Institute of Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91052 Erlangen, Germany.
Thonn V; Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91052 Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), 91052 Erlangen, Germany.
Cordsmeier A; Institute of Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91052 Erlangen, Germany.
Neurath MF; Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91052 Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), 91052 Erlangen, Germany.
Ensser A; Institute of Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91052 Erlangen, Germany.
Becker C; Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91052 Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), 91052 Erlangen, Germany.
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Źródło :
Cells [Cells] 2022 Apr 08; Vol. 11 (8). Date of Electronic Publication: 2022 Apr 08.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19*/pathology
Epithelial Cells*/metabolism
Epithelial Cells*/virology
Histone-Lysine N-Methyltransferase*/genetics
Serine Endopeptidases*/genetics
Antiviral Agents/pharmacology ; Humans ; SARS-CoV-2/drug effects ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Internalization
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
An allosteric HTRA1-calpain 2 complex with restricted activation profile.
Autorzy :
Rey J; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany.
Breiden M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany.
Lux V; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany.
Bluemke A; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany.
Steindel M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany.
Ripkens K; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany.
Möllers B; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany.
Bravo Rodriguez K; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany.
Boisguerin P; PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295 Montpellier Cedex 5, France.
Volkmer R; Institut für Medizinische Immunologie, Charité - Universitätsmedizin Berlin, 10115 Berlin, Germany.
Mieres-Perez J; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany.
Clausen T; Research Institute of Molecular Pathology - IMP, 1030 Vienna, Austria.
Sanchez-Garcia E; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany.
Ehrmann M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitaetsstrasse, 45141 Essen, Germany.; School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Apr 05; Vol. 119 (14), pp. e2113520119. Date of Electronic Publication: 2022 Mar 29.
Typ publikacji :
Journal Article
MeSH Terms :
Calpain*/metabolism
Serine Endopeptidases*/metabolism
Amyloid/metabolism ; High-Temperature Requirement A Serine Peptidase 1/chemistry ; Proteolysis ; Serine Proteases/metabolism
Czasopismo naukowe
Tytuł :
A novel halolysin without C-terminal extension from an extremely halophilic archaeon.
Autorzy :
Hou J; School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Jingkou District, Zhenjiang, 212013, Jiangsu, People's Republic of China.
Li SY; School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Jingkou District, Zhenjiang, 212013, Jiangsu, People's Republic of China.
Zhao YJ; School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Jingkou District, Zhenjiang, 212013, Jiangsu, People's Republic of China.
Cui HL; School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Jingkou District, Zhenjiang, 212013, Jiangsu, People's Republic of China. .
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Źródło :
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2022 Apr; Vol. 106 (8), pp. 3009-3019. Date of Electronic Publication: 2022 Apr 18.
Typ publikacji :
Journal Article
MeSH Terms :
Salt Tolerance*
Serine Endopeptidases*/metabolism
Peptide Hydrolases/metabolism ; Sodium Chloride/metabolism
Czasopismo naukowe
Tytuł :
Protein expression of transmembrane protease serine 4 in the gastrointestinal tract and in healthy, cancer, and SARS‑CoV‑2 infected lungs.
Autorzy :
Kerslake R; Division of Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH.
Randeva HS; Warwickshire Institute for The Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire (UHCW) NHS Trust, Coventry CV2 2DX, UK.
Jonigk D; Institute for Pathology, Hannover Medical School, D‑30625 Hannover, Germany.
Werlein C; Institute for Pathology, Hannover Medical School, D‑30625 Hannover, Germany.
Robertus JL; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
Katopodis P; Division of Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK.
Jasker P; Pathologie Grünstrasse, D‑40212 Düsseldorf, Germany.
Spandidos DA; Laboratory of Clinical Virology, Medical School, University of Crete, 71409 Heraklion, Greece.
Kyrou I; Warwickshire Institute for The Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire (UHCW) NHS Trust, Coventry CV2 2DX, UK.
Karteris E; Division of Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2022 Apr; Vol. 25 (4). Date of Electronic Publication: 2022 Feb 25.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
COVID-19/*pathology
Gastrointestinal Tract/*pathology
Lung/*pathology
Lung Neoplasms/*pathology
Membrane Proteins/*metabolism
Serine Endopeptidases/*metabolism
Aged ; Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/complications ; COVID-19/virology ; Gastrointestinal Tract/virology ; Humans ; Immunohistochemistry ; Lung/virology ; Lung Neoplasms/complications ; Male ; Membrane Proteins/analysis ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity ; Serine Endopeptidases/analysis ; Virus Internalization
Czasopismo naukowe
Tytuł :
Transmembrane serine protease 2 is a prognostic factor for lung adenocarcinoma.
Autorzy :
Schneider MA; Translational Research Unit, Thoraxklinik at Heidelberg University Hospital, D-69126 Heidelberg, Germany.
Richtmann S; Translational Research Unit, Thoraxklinik at Heidelberg University Hospital, D-69126 Heidelberg, Germany.
Gründing AR; Department of Respiratory Medicine, Hannover Medical School, D-30625 Hannover, Germany.
Wrenger S; Department of Respiratory Medicine, Hannover Medical School, D-30625 Hannover, Germany.
Welte T; Department of Respiratory Medicine, Hannover Medical School, D-30625 Hannover, Germany.
Meister M; Translational Research Unit, Thoraxklinik at Heidelberg University Hospital, D-69126 Heidelberg, Germany.
Kriegsmann M; Translational Research Center Heidelberg (TLRC), Member of The German Center for Lung Research (DZL), D-69120 Heidelberg, Germany.
Winter H; Translational Research Center Heidelberg (TLRC), Member of The German Center for Lung Research (DZL), D-69120 Heidelberg, Germany.
Muley T; Translational Research Unit, Thoraxklinik at Heidelberg University Hospital, D-69126 Heidelberg, Germany.
Janciauskiene S; Department of Respiratory Medicine, Hannover Medical School, D-30625 Hannover, Germany.
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Źródło :
International journal of oncology [Int J Oncol] 2022 Apr; Vol. 60 (4). Date of Electronic Publication: 2022 Feb 25.
Typ publikacji :
Journal Article
MeSH Terms :
Prognosis*
Adenocarcinoma of Lung/*diagnosis
Serine Endopeptidases/*analysis
Adenocarcinoma of Lung/blood ; Adenocarcinoma of Lung/genetics ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/blood ; Cell Line, Tumor ; Humans ; Serine Endopeptidases/blood
Czasopismo naukowe
Tytuł :
Renin-angiotensin system blockade on angiotensin-converting enzyme 2 and TMPRSS2 in human type II pneumocytes.
Autorzy :
Silva MG; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Dpto. Química Biológica, IQUIFIB (UBA-CONICET), Buenos Aires, Argentina.
Falcoff NL; Servicio Unificado de Patología Hospital Prov de Tórax 'Dr. A. Cetrángolo' y Municipal de Vicente López 'Prof. B. Houssay', Buenos Aires, Argentina.
Corradi GR; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Dpto. Química Biológica, IQUIFIB (UBA-CONICET), Buenos Aires, Argentina.
Alfie J; Servicio de Hipertensión Arterial, Hospital Italiano, Buenos Aires, Argentina.
Seguel RF; Servicio de Neumonología Hospital Prov de Tórax 'Dr. A. Cetrángolo', Buenos Aires, Argentina.
Tabaj GC; Servicio de Neumonología Hospital Prov de Tórax 'Dr. A. Cetrángolo', Buenos Aires, Argentina.
Iglesias LI; Servicio Unificado de Patología Hospital Prov de Tórax 'Dr. A. Cetrángolo' y Municipal de Vicente López 'Prof. B. Houssay', Buenos Aires, Argentina.
Nuñez M; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Matemáticas, Buenos Aires, Argentina.
Guman GR; Servicio Unificado de Patología Hospital Prov de Tórax 'Dr. A. Cetrángolo' y Municipal de Vicente López 'Prof. B. Houssay', Buenos Aires, Argentina.
Gironacci MM; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Dpto. Química Biológica, IQUIFIB (UBA-CONICET), Buenos Aires, Argentina. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2022 Mar 15; Vol. 293, pp. 120324. Date of Electronic Publication: 2022 Jan 12.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Alveolar Epithelial Cells/*metabolism
Angiotensin Receptor Antagonists/*pharmacology
Angiotensin-Converting Enzyme 2/*metabolism
Angiotensin-Converting Enzyme Inhibitors/*pharmacology
Renin-Angiotensin System/*physiology
Serine Endopeptidases/*metabolism
Adult ; Age Factors ; Aged ; Alveolar Epithelial Cells/chemistry ; Alveolar Epithelial Cells/drug effects ; Angiotensin I/metabolism ; Angiotensin II/metabolism ; Angiotensin-Converting Enzyme 2/analysis ; Angiotensin-Converting Enzyme 2/antagonists & inhibitors ; Female ; Humans ; Lung/chemistry ; Lung/drug effects ; Lung/metabolism ; Male ; Middle Aged ; Peptide Fragments/metabolism ; Renin-Angiotensin System/drug effects ; Retrospective Studies ; Serine Endopeptidases/analysis ; Smoking/metabolism ; Smoking/pathology
Czasopismo naukowe
Tytuł :
Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases.
Autorzy :
Chaudhry MZ; Department of Viral Immunology, Helmholtz Centre for Infection Researchgrid.7490.a, Braunschweig, Germany.
Eschke K; Department of Viral Immunology, Helmholtz Centre for Infection Researchgrid.7490.a, Braunschweig, Germany.
Hoffmann M; Infection Biology Unit, German Primate Centergrid.418215.b, Göttingen, Germany.; Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany.
Grashoff M; Research Group Innate Immunity and Infection, Helmholtz Centre for Infection Researchgrid.7490.a, Braunschweig, Germany.
Abassi L; Department of Viral Immunology, Helmholtz Centre for Infection Researchgrid.7490.a, Braunschweig, Germany.
Kim Y; Department of Viral Immunology, Helmholtz Centre for Infection Researchgrid.7490.a, Braunschweig, Germany.
Brunotte L; Institut für Virologie (IMV), Westfälische Wilhelms-Universität Münster, Münster, Germany.
Ludwig S; Institut für Virologie (IMV), Westfälische Wilhelms-Universität Münster, Münster, Germany.
Kröger A; Research Group Innate Immunity and Infection, Helmholtz Centre for Infection Researchgrid.7490.a, Braunschweig, Germany.; Institute of Medical Microbiology and Hospital Hygiene, Otto von Guericke University, Magdeburg, Germany.
Klawonn F; Biostatistics Group, Helmholtz Centre for Infection Researchgrid.7490.a, Braunschweig, Germany.; Department of Computer Science, Ostfalia University, Wolfenbüttel, Germany.
Pöhlmann SH; Infection Biology Unit, German Primate Centergrid.418215.b, Göttingen, Germany.; Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany.
Cicin-Sain L; Department of Viral Immunology, Helmholtz Centre for Infection Researchgrid.7490.a, Braunschweig, Germany.; Centre for Individualized Infection Medicine (CIIM), Hannover, Germany.
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Źródło :
Journal of virology [J Virol] 2022 Mar 09; Vol. 96 (5), pp. e0218621. Date of Electronic Publication: 2022 Jan 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*metabolism
Furin/*metabolism
SARS-CoV-2/*physiology
Serine Endopeptidases/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Adaptation, Physiological ; Animals ; COVID-19/genetics ; COVID-19/virology ; Chlorocebus aethiops ; Cytopathogenic Effect, Viral ; Furin/genetics ; HEK293 Cells ; High-Throughput Nucleotide Sequencing ; Humans ; Mutation ; SARS-CoV-2/genetics ; Serine Endopeptidases/genetics ; Spike Glycoprotein, Coronavirus/genetics ; Vero Cells ; Virus Replication
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa.
Autorzy :
Sorensen AB; Global Research, Novo Nordisk A/S, 2760, Måløv, Denmark.; Department of Chemistry and Bioscience, Aalborg University, 9220, Ålborg, Denmark.
Greisen PJ; Global Research, Novo Nordisk A/S, 2760, Måløv, Denmark.
Madsen JJ; Global and Planetary Health, College of Public Health, University of South Florida, Tampa, FL, 33612, USA.; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.
Lund J; Global Research, Novo Nordisk A/S, 2760, Måløv, Denmark.
Andersen G; Global Research, Novo Nordisk A/S, 2760, Måløv, Denmark.
Wulff-Larsen PG; Global Research, Novo Nordisk A/S, 2760, Måløv, Denmark.
Pedersen AA; Global Research, Novo Nordisk A/S, 2760, Måløv, Denmark.
Gandhi PS; Global Research, Novo Nordisk A/S, 2760, Måløv, Denmark.
Overgaard MT; Department of Chemistry and Bioscience, Aalborg University, 9220, Ålborg, Denmark.
Østergaard H; Global Research, Novo Nordisk A/S, 2760, Måløv, Denmark.
Olsen OH; Global Research, Novo Nordisk A/S, 2760, Måløv, Denmark. .; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark. .
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Źródło :
Scientific reports [Sci Rep] 2022 Mar 08; Vol. 12 (1), pp. 3747. Date of Electronic Publication: 2022 Mar 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Factor VIIa*
Serine Endopeptidases*/metabolism
Substrate Specificity ; Trypsin/metabolism
Czasopismo naukowe
Tytuł :
The discovery and development of transmembrane serine protease 2 (TMPRSS2) inhibitors as candidate drugs for the treatment of COVID-19.
Autorzy :
Mantzourani C; Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens, Greece.; Center of Excellence for Drug Design and Discovery, National and Kapodistrian University of Athens, Athens, Greece.
Vasilakaki S; Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens, Greece.; Center of Excellence for Drug Design and Discovery, National and Kapodistrian University of Athens, Athens, Greece.
Gerogianni VE; Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens, Greece.; Center of Excellence for Drug Design and Discovery, National and Kapodistrian University of Athens, Athens, Greece.
Kokotos G; Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens, Greece.; Center of Excellence for Drug Design and Discovery, National and Kapodistrian University of Athens, Athens, Greece.
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Źródło :
Expert opinion on drug discovery [Expert Opin Drug Discov] 2022 Mar; Vol. 17 (3), pp. 231-246. Date of Electronic Publication: 2022 Jan 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
COVID-19*/drug therapy
Serine Endopeptidases*/metabolism
Virus Internalization*/drug effects
Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Humans ; Protease Inhibitors/pharmacology ; SARS-CoV-2
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Clinical Significance of Hepsin and Underlying Signaling Pathways in Prostate Cancer.
Autorzy :
Lu L; GoPath Laboratories, Buffalo Grove, IL 60089, USA.
Cole A; TruCore Pathology, Little Rock, AR 72204, USA.
Huang D; GoPath Laboratories, Buffalo Grove, IL 60089, USA.
Wang Q; GoPath Laboratories, Buffalo Grove, IL 60089, USA.
Guo Z; GoPath Laboratories, Buffalo Grove, IL 60089, USA.
Yang W; GoPath Laboratories, Buffalo Grove, IL 60089, USA.; Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Lu J; GoPath Laboratories, Buffalo Grove, IL 60089, USA.
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Źródło :
Biomolecules [Biomolecules] 2022 Jan 25; Vol. 12 (2). Date of Electronic Publication: 2022 Jan 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Prostatic Neoplasms*/metabolism
Serine Endopeptidases*/genetics
Serine Endopeptidases*/metabolism
Cell Line, Tumor ; Humans ; Male ; Neoplasm Invasiveness ; Signal Transduction
Czasopismo naukowe
Tytuł :
Characteristics of Angiotensin I-converting enzyme 2, type II transmembrane serine protease 2 and 4 in tree shrew indicate it as a potential animal model for SARS-CoV-2 infection.
Autorzy :
Li N; The Center of Tree Shrew Germplasm Resources, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Yunnan Innovation Team of Standardization and Application Research in Tupaia Belangeri Chinensis, Kunming, China.
Gu W; The Center of Tree Shrew Germplasm Resources, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Yunnan Innovation Team of Standardization and Application Research in Tupaia Belangeri Chinensis, Kunming, China.
Lu C; The Center of Tree Shrew Germplasm Resources, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Yunnan Innovation Team of Standardization and Application Research in Tupaia Belangeri Chinensis, Kunming, China.
Sun X; The Center of Tree Shrew Germplasm Resources, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Yunnan Innovation Team of Standardization and Application Research in Tupaia Belangeri Chinensis, Kunming, China.
Tong P; The Center of Tree Shrew Germplasm Resources, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Yunnan Innovation Team of Standardization and Application Research in Tupaia Belangeri Chinensis, Kunming, China.
Han Y; The Center of Tree Shrew Germplasm Resources, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Yunnan Innovation Team of Standardization and Application Research in Tupaia Belangeri Chinensis, Kunming, China.
Wang W; The Center of Tree Shrew Germplasm Resources, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Yunnan Innovation Team of Standardization and Application Research in Tupaia Belangeri Chinensis, Kunming, China.
Dai J; The Center of Tree Shrew Germplasm Resources, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Yunnan Innovation Team of Standardization and Application Research in Tupaia Belangeri Chinensis, Kunming, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 2836-2850.
Typ publikacji :
Journal Article
MeSH Terms :
SARS-CoV-2*
Angiotensin-Converting Enzyme 2/*genetics
COVID-19/*etiology
Membrane Proteins/*genetics
Serine Endopeptidases/*genetics
Tupaiidae/*genetics
Tupaiidae/*metabolism
Amino Acid Sequence ; Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Bioengineering ; COVID-19/enzymology ; COVID-19/genetics ; Computational Biology ; Disease Models, Animal ; Female ; Humans ; Male ; Membrane Proteins/chemistry ; Membrane Proteins/metabolism ; Models, Molecular ; Phylogeny ; Protein Structure, Tertiary ; Sequence Homology, Amino Acid ; Serine Endopeptidases/chemistry ; Serine Endopeptidases/metabolism ; Structural Homology, Protein ; Tissue Distribution ; Tupaiidae/virology
Czasopismo naukowe
Tytuł :
Knocking down Sterol regulatory element binding protein 2 (SREBF2) inhibits the Serine Protease 8 (PRSS8) /sodium channel epithelial 1alpha subunit (SCNN1A) axis to reduce the cell proliferation, migration and epithelial-mesenchymal transformation of ovarian cancer.
Autorzy :
Cai C; Department of Gynaecology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, China.
Zhang Y; Department of Gynaecology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, China.
Peng X; Department of Gynaecology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (2), pp. 9390-9400.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Epithelial Sodium Channels*/genetics
Epithelial Sodium Channels*/metabolism
Gene Knockdown Techniques*
Neoplasm Proteins*/genetics
Neoplasm Proteins*/metabolism
Ovarian Neoplasms*/genetics
Ovarian Neoplasms*/metabolism
Serine Endopeptidases*/genetics
Serine Endopeptidases*/metabolism
Sterol Regulatory Element Binding Protein 2*/genetics
Sterol Regulatory Element Binding Protein 2*/metabolism
Cell Movement/*genetics
Cell Proliferation/*genetics
Epithelial-Mesenchymal Transition/*genetics
Cell Line, Tumor ; Female ; Humans
Czasopismo naukowe
Tytuł :
Polymorphisms and mutations of ACE2 and TMPRSS2 genes are associated with COVID-19: a systematic review.
Autorzy :
Li J; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Wang Y; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Liu Y; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. .; The Third People's Hospital of Zigong, Zigong, Sichuan, China. .
Zhang Z; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Zhai Y; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Dai Y; The Third People's Hospital of Zigong, Zigong, Sichuan, China.
Wu Z; Zigong Hospital of Traditional Chinese Medicine, Zigong, Sichuan, China.
Nie X; The Third People's Hospital of Zigong, Zigong, Sichuan, China.
Du L; The Third People's Hospital of Zigong, Zigong, Sichuan, China.
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Źródło :
European journal of medical research [Eur J Med Res] 2022 Feb 22; Vol. 27 (1), pp. 26. Date of Electronic Publication: 2022 Feb 22.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
Mutation*
Polymorphism, Single Nucleotide*
SARS-CoV-2*
Angiotensin-Converting Enzyme 2/*genetics
COVID-19/*genetics
Serine Endopeptidases/*genetics
Angiotensin-Converting Enzyme 2/physiology ; COVID-19/etiology ; Genetic Predisposition to Disease ; Humans ; Serine Endopeptidases/physiology
Czasopismo naukowe
Tytuł :
Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures.
Autorzy :
Guo W; Department of Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, UK.
Porter LM; Department of Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, UK.
Crozier TW; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.
Coates M; Department of Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, UK.
Jha A; Department of Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, UK.
McKie M; Medical Research Council, Biostatistic Unit, Cambridge, UK.
Nathan JA; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.
Lehner PJ; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.
Greenwood EJ; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK .
McCaughan F; Department of Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, UK .
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Źródło :
Life science alliance [Life Sci Alliance] 2022 Feb 02; Vol. 5 (4). Date of Electronic Publication: 2022 Feb 02 (Print Publication: 2022).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Respiratory Mucosa/*drug effects
Respiratory Mucosa/*metabolism
Respiratory Mucosa/*virology
SARS-CoV-2/*drug effects
SARS-CoV-2/*physiology
Serine Endopeptidases/*metabolism
Serine Proteinase Inhibitors/*administration & dosage
Administration, Topical ; Androgens/metabolism ; Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Antiviral Agents/pharmacology ; COVID-19/prevention & control ; COVID-19/virology ; Cells, Cultured ; Epithelial Cells ; Esters/pharmacology ; Gene Expression ; Goblet Cells/immunology ; Goblet Cells/metabolism ; Guanidines/pharmacology ; Host-Pathogen Interactions/drug effects ; Humans ; Serine Endopeptidases/genetics ; Signal Transduction ; Virus Internalization/drug effects ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies.
Autorzy :
Durdagi S; Department of Biophysics, Computational Biology and Molecular Simulations Laboratory, School of Medicine, Bahçeşehir University, Istanbul, Turkey. Electronic address: .
Avsar T; Department of Medical Biology, School of Medicine, Bahçeşehir University, Istanbul, Turkey.
Orhan MD; Department of Medical Biology, School of Medicine, Bahçeşehir University, Istanbul, Turkey.
Serhatli M; The Scientific and Technological Research Council of Turkey (TÜBİTAK) Marmara Research Center (MAM), Genetic Engineering and Biotechnology Institute, 41470 Gebze, Kocaeli.
Balcioglu BK; The Scientific and Technological Research Council of Turkey (TÜBİTAK) Marmara Research Center (MAM), Genetic Engineering and Biotechnology Institute, 41470 Gebze, Kocaeli.
Ozturk HU; The Scientific and Technological Research Council of Turkey (TÜBİTAK) Marmara Research Center (MAM), Genetic Engineering and Biotechnology Institute, 41470 Gebze, Kocaeli.
Kayabolen A; Brain Cancer Research and Therapy Laboratory, Koç University School of Medicine, 34450 Istanbul, Turkey.
Cetin Y; The Scientific and Technological Research Council of Turkey (TÜBİTAK) Marmara Research Center (MAM), Genetic Engineering and Biotechnology Institute, 41470 Gebze, Kocaeli.
Aydinlik S; The Scientific and Technological Research Council of Turkey (TÜBİTAK) Marmara Research Center (MAM), Genetic Engineering and Biotechnology Institute, 41470 Gebze, Kocaeli.
Bagci-Onder T; Brain Cancer Research and Therapy Laboratory, Koç University School of Medicine, 34450 Istanbul, Turkey; Koç University Research Center for Translational Medicine, 34450 Istanbul, Turkey.
Tekin S; The Scientific and Technological Research Council of Turkey (TÜBİTAK) Marmara Research Center (MAM), Genetic Engineering and Biotechnology Institute, 41470 Gebze, Kocaeli; Department of Basic Sciences, Division of Medical Biology, Faculty of Medicine, University of Health Sciences, Istanbul, Turkey.
Demirci H; Department of Molecular Biology and Genetics, Koç University, 34450 Istanbul, Turkey.
Guzel M; Department of Medical Pharmacology, International School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Akdemir A; Department of Pharmacology, Computer-aided Drug Discovery Laboratory, Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, Turkey.
Calis S; Department of Medical Biology, School of Medicine, Bahçeşehir University, Istanbul, Turkey; Department of Molecular Biology-Genetics and Biotechnology, Istanbul Technical University, 34485 Istanbul, Turkey.
Oktay L; Department of Biophysics, Computational Biology and Molecular Simulations Laboratory, School of Medicine, Bahçeşehir University, Istanbul, Turkey.
Tolu I; Department of Biophysics, Computational Biology and Molecular Simulations Laboratory, School of Medicine, Bahçeşehir University, Istanbul, Turkey.
Butun YE; Department of Medical Pharmacology, International School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Erdemoglu E; Department of Biophysics, Computational Biology and Molecular Simulations Laboratory, School of Medicine, Bahçeşehir University, Istanbul, Turkey; Faculty of Medicine, Mersin University, Mersin, Turkey.
Olkan A; Department of Biophysics, Computational Biology and Molecular Simulations Laboratory, School of Medicine, Bahçeşehir University, Istanbul, Turkey.
Tokay N; The Scientific and Technological Research Council of Turkey (TÜBİTAK) Marmara Research Center (MAM), Genetic Engineering and Biotechnology Institute, 41470 Gebze, Kocaeli.
Işık Ş; The Scientific and Technological Research Council of Turkey (TÜBİTAK) Marmara Research Center (MAM), Genetic Engineering and Biotechnology Institute, 41470 Gebze, Kocaeli.
Ozcan A; Department of Biophysics, Computational Biology and Molecular Simulations Laboratory, School of Medicine, Bahçeşehir University, Istanbul, Turkey; Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.
Acar E; Department of Biophysics, Computational Biology and Molecular Simulations Laboratory, School of Medicine, Bahçeşehir University, Istanbul, Turkey; Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.
Buyukkilic S; Department of Biophysics, Computational Biology and Molecular Simulations Laboratory, School of Medicine, Bahçeşehir University, Istanbul, Turkey; Faculty of Science, Necmettin Erbakan University, Konya, Turkey.
Yumak Y; Department of Biophysics, Computational Biology and Molecular Simulations Laboratory, School of Medicine, Bahçeşehir University, Istanbul, Turkey; Faculty of Science and Letters, Tokat Gaziosmanpaşa University, Tokat, Turkey.
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Źródło :
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2022 Feb 02; Vol. 30 (2), pp. 963-974. Date of Electronic Publication: 2021 Oct 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetates/*pharmacology
Angiotensin-Converting Enzyme 2/*metabolism
Cyclopropanes/*pharmacology
Quinolines/*pharmacology
SARS-CoV-2/*physiology
Serine Endopeptidases/*metabolism
Sulfides/*pharmacology
A549 Cells ; Acetates/chemistry ; Angiotensin-Converting Enzyme 2/chemistry ; Animals ; Cell Survival/drug effects ; Chlorocebus aethiops ; Cyclopropanes/chemistry ; Drug Repositioning ; HEK293 Cells ; Humans ; Models, Molecular ; Molecular Docking Simulation ; Molecular Structure ; Neutralization Tests ; Protein Conformation ; Quinolines/chemistry ; SARS-CoV-2/drug effects ; Serine Endopeptidases/chemistry ; Sulfides/chemistry ; Vero Cells ; Virus Internalization/drug effects
Czasopismo naukowe

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