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Wyszukujesz frazę ""Serotonin"" wg kryterium: Temat


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Tytuł :
Déjà-vu? Neural and behavioural effects of the 5-HT 4 receptor agonist, prucalopride, in a hippocampal-dependent memory task.
Autorzy :
de Cates AN; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK. .; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK. .
Wright LC; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK.
Martens MAG; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
Gibson D; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK.
Türkmen C; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.
Filippini N; IRCCS San Camillo Hospital, Venice, Italy.
Cowen PJ; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK.
Harmer CJ; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK.; Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Oxford, UK.
Murphy SE; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK.
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Źródło :
Translational psychiatry [Transl Psychiatry] 2021 Oct 04; Vol. 11 (1), pp. 497. Date of Electronic Publication: 2021 Oct 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Serotonin*
Serotonin 5-HT4 Receptor Agonists*/pharmacology
Benzofurans ; Hippocampus/metabolism ; Humans ; Receptors, Serotonin, 5-HT4/metabolism
Czasopismo naukowe
Tytuł :
Modulation of the 5-HT 3 A receptor current by desacylbaldrinal.
Autorzy :
Wang LX; State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Chen HL; State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yan HL; State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Tang F; State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Zhang H; State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Li HX; Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Ye Q; State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Peng C; State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Tan YZ; State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu, China.; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
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Źródło :
Natural product research [Nat Prod Res] 2021 Aug; Vol. 35 (16), pp. 2758-2762. Date of Electronic Publication: 2019 Sep 10.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, Serotonin, 5-HT3*
Serotonin*
Iridoids/*pharmacology
Serotonin 5-HT3 Receptor Antagonists/*pharmacology
Valerian/*chemistry
Humans ; Iridoids/isolation & purification ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Serotonin 5-HT3 Receptor Antagonists/isolation & purification
Czasopismo naukowe
Tytuł :
The Modulatory Role of Serotonin on Human Impulsive Aggression.
Autorzy :
da Cunha-Bang S; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; Psychiatric Center North Zealand, Mental Health Services in the Capital Region of Denmark, Hillerød, Denmark. Electronic address: .
Knudsen GM; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Źródło :
Biological psychiatry [Biol Psychiatry] 2021 Oct 01; Vol. 90 (7), pp. 447-457. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Aggression*
Serotonin*
Brain/diagnostic imaging ; Brain/metabolism ; Humans ; Impulsive Behavior ; Monoamine Oxidase/genetics ; Monoamine Oxidase/metabolism ; Serotonin Plasma Membrane Transport Proteins/genetics ; Serotonin Plasma Membrane Transport Proteins/metabolism
Czasopismo naukowe
Tytuł :
A comprehensive assessment of genetic variation in serotonin transporter gene (5-HTTLPR+rs25531) and the response to dapoxetine in Chinese patients with premature ejaculation.
Autorzy :
Huang Y; Department of Urology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Gao J; Department of Urology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Gao P; Department of Urology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Peng D; Department of Urology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Dai Y; Department of Andrology, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, China.
Jiang H; Department of Andrology, Peking University Third Hospital, Beijing, China.; Department of Human Sperm Bank, Peking University Third Hospital, Beijing, China.
Zhang X; Department of Urology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
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Źródło :
Andrologia [Andrologia] 2021 Sep; Vol. 53 (8), pp. e14141. Date of Electronic Publication: 2021 Jun 12.
Typ publikacji :
Journal Article
MeSH Terms :
Premature Ejaculation*/drug therapy
Premature Ejaculation*/genetics
Serotonin Plasma Membrane Transport Proteins*/genetics
Benzylamines ; China ; Ejaculation ; Humans ; Male ; Naphthalenes ; Polymorphism, Genetic ; Serotonin Uptake Inhibitors/therapeutic use ; Treatment Outcome
Czasopismo naukowe
Tytuł :
The Relationship between Genotype of Serotonin-transporter-linked Polymorphic Region (5-HTTLPR) and Migraine combined with Depression.
Autorzy :
Han L; Department of Psychosomatic, Mental Health Center, Zhejiang University School of Medicine, China.
Yu Z; Department of Psychosomatic, Mental Health Center, Zhejiang University School of Medicine, China.
Mao H; Department of Psychosomatic, Mental Health Center, Zhejiang University School of Medicine, China.
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Źródło :
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP [J Coll Physicians Surg Pak] 2021 Aug; Vol. 31 (8), pp. 998-1000.
Typ publikacji :
Journal Article
MeSH Terms :
Migraine Disorders*/genetics
Serotonin*
Alleles ; China/epidemiology ; Depression/epidemiology ; Depression/genetics ; Genotype ; Humans ; Polymorphism, Genetic ; Serotonin Plasma Membrane Transport Proteins/genetics
Czasopismo naukowe
Tytuł :
Drug interaction between a selective serotonin reuptake inhibitor and a triptan leading to serotonin toxicity: a case report and review of the literature.
Autorzy :
Jin G; Redcliffe Hospital, Anzac Avenue, Redcliffe, QLD, 4020, Australia. .
Stokes P; Redcliffe Hospital, Anzac Avenue, Redcliffe, QLD, 4020, Australia.
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Źródło :
Journal of medical case reports [J Med Case Rep] 2021 Jul 26; Vol. 15 (1), pp. 371. Date of Electronic Publication: 2021 Jul 26.
Typ publikacji :
Case Reports; Journal Article; Review
MeSH Terms :
Serotonin*
Serotonin Uptake Inhibitors*/adverse effects
Adult ; Drug Interactions ; Female ; Humans ; Serotonin Receptor Agonists ; Tryptamines/adverse effects
Czasopismo naukowe
Tytuł :
Serotonin Syndrome Induced by a Single Dose of Venlafaxine and Magnesium Valproate.
Autorzy :
Zhan Z; Emergency Department, The First Affiliated Hospital of Nanchang University, Jiangxi, China, .
Cao CS
Huang L
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Źródło :
Psychiatria Danubina [Psychiatr Danub] 2021 Summer; Vol. 33 (2), pp. 193-195.
Typ publikacji :
Journal Article
MeSH Terms :
Serotonin Syndrome*/chemically induced
Valproic Acid*/adverse effects
Cyclohexanols ; Humans ; Serotonin ; Serotonin Uptake Inhibitors ; Venlafaxine Hydrochloride/adverse effects
Czasopismo naukowe
Tytuł :
Drug design of new 5-HT 6 R antagonists aided by artificial neural networks.
Autorzy :
da Silva AP; Departamento de Química e Física Molecular, Instituto de Química de São Carlos, Universidade de São Paulo, C.P 780, 13560-970, São Carlos, SP, Brazil.
Chiari LPA; Departamento de Química e Física Molecular, Instituto de Química de São Carlos, Universidade de São Paulo, C.P 780, 13560-970, São Carlos, SP, Brazil.
Guimaraes AR; Departamento de Química e Física Molecular, Instituto de Química de São Carlos, Universidade de São Paulo, C.P 780, 13560-970, São Carlos, SP, Brazil.
Honorio KM; Escola de Artes, Ciência e Humanidades, Universidade de São Paulo, São Paulo, 03828-000, Brazil.
da Silva ABF; Departamento de Química e Física Molecular, Instituto de Química de São Carlos, Universidade de São Paulo, C.P 780, 13560-970, São Carlos, SP, Brazil. Electronic address: .
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Źródło :
Journal of molecular graphics & modelling [J Mol Graph Model] 2021 May; Vol. 104, pp. 107844. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Serotonin*
Humans ; Neural Networks, Computer ; Receptors, Serotonin ; Serotonin Antagonists/pharmacology
Czasopismo naukowe
Tytuł :
Large-scale network dynamics in neural response to emotionally negative stimuli linked to serotonin 1A binding in major depressive disorder.
Autorzy :
Schneck N; Department of Psychiatry, Columbia University, New York, NY, USA. .; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA. .
Tu T; Department of Biomedical Engineering, Columbia University, New York, NY, USA.
Falcone HR; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
Miller JM; Department of Psychiatry, Columbia University, New York, NY, USA.; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
Zanderigo F; Department of Psychiatry, Columbia University, New York, NY, USA.; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
Sublette ME; Department of Psychiatry, Columbia University, New York, NY, USA.; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
Oquendo MA; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Stanley B; Department of Psychiatry, Columbia University, New York, NY, USA.; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
Burke A; Department of Psychiatry, Columbia University, New York, NY, USA.; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
Ochsner K; Department of Psychology, Columbia University, New York, NY, USA.
Sajda P; Department of Biomedical Engineering, Columbia University, New York, NY, USA.; Data Science Institute, Columbia University, New York, NY, USA.
John Mann J; Department of Psychiatry, Columbia University, New York, NY, USA.; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
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Źródło :
Molecular psychiatry [Mol Psychiatry] 2021 Jun; Vol. 26 (6), pp. 2393-2401. Date of Electronic Publication: 2020 Apr 30.
Typ publikacji :
Journal Article
MeSH Terms :
Depressive Disorder, Major*/diagnostic imaging
Serotonin*
Brain/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Positron-Emission Tomography ; Receptor, Serotonin, 5-HT1A
Czasopismo naukowe
Tytuł :
A quantitative method for the selective 5-HT2A agonist 25CN-NBOH in rat plasma and brain.
Autorzy :
Breusova K; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark.
Ernstsen KG; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark.
Palner M; Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark; Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.
Linnet K; Section of Forensic Chemistry, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of Coapenhagen, Frederik V's vej 11, 2100, Copenhagen, Denmark.
Kristensen JL; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark.
Kretschmann AC; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark. Electronic address: .
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Źródło :
Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2021 May 30; Vol. 199, pp. 114016. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article
MeSH Terms :
Brain*
Serotonin 5-HT2 Receptor Agonists*
Animals ; Biotransformation ; Microsomes, Liver ; Rats ; Rats, Long-Evans ; Receptor, Serotonin, 5-HT2A
Czasopismo naukowe
Tytuł :
Serotonin-related rodent models of early-life exposure relevant for neurodevelopmental vulnerability to psychiatric disorders.
Autorzy :
Adjimann TS; Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
Argañaraz CV; Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
Soiza-Reilly M; Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina. .
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Źródło :
Translational psychiatry [Transl Psychiatry] 2021 May 11; Vol. 11 (1), pp. 280. Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Rodentia*
Serotonin*
Animals ; Antidepressive Agents ; Anxiety Disorders ; Serotonin Uptake Inhibitors
Czasopismo naukowe
Tytuł :
Delayed-Onset Serotonin Syndrome Is Not Unusual With Linezolid.
Autorzy :
Prakash S; Department of Neurology, Smt. B. K. Shah, Medical Institute and Research Centre, Sumandeep Vidyapeeth, Piparia, Waghodia, Vadodara Gujarat, India .
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Źródło :
Clinical neuropharmacology [Clin Neuropharmacol] 2021 May-Jun 01; Vol. 44 (3), pp. 116.
Typ publikacji :
Letter; Comment
MeSH Terms :
Serotonin Syndrome*/chemically induced
Acetamides/adverse effects ; Humans ; Linezolid/adverse effects ; Serotonin Uptake Inhibitors
Opinia redakcyjna
Tytuł :
Ferulic acid alleviates abnormal behaviors in isolation-reared mice via 5-HT 1A receptor partial agonist activity.
Autorzy :
Araki R; Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan. .
Yasubuchi A; Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan.
Ikegaya M; Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan.
Hojo C; Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan.
Tachioka H; Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan.
Kawai K; Laboratory of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan.
Omote M; Laboratory of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan.
Kita A; Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan.
Yabe T; Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan. .
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2021 Aug; Vol. 238 (8), pp. 2147-2154. Date of Electronic Publication: 2021 Apr 08.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Partial Agonism*
Coumaric Acids/*therapeutic use
Receptor, Serotonin, 5-HT1A/*metabolism
Serotonin 5-HT1 Receptor Agonists/*therapeutic use
Serotonin Receptor Agonists/*therapeutic use
Social Isolation/*psychology
8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology ; Animals ; Coumaric Acids/pharmacology ; Dopamine/metabolism ; Dose-Response Relationship, Drug ; Male ; Mice ; Microdialysis/methods ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/metabolism ; Serotonin/metabolism ; Serotonin 5-HT1 Receptor Agonists/pharmacology ; Serotonin Antagonists/pharmacology ; Serotonin Receptor Agonists/pharmacology
Czasopismo naukowe
Tytuł :
Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction.
Autorzy :
Li Y; Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland.; IDG McGovern Institute for Brain Research, Peking University, Beijing 100871, China.
Simmler LD; Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland.; IDG McGovern Institute for Brain Research, Peking University, Beijing 100871, China.
Van Zessen R; Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland.; IDG McGovern Institute for Brain Research, Peking University, Beijing 100871, China.
Flakowski J; Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland.; Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, USA.
Wan JX; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.; IDG McGovern Institute for Brain Research, Peking University, Beijing 100871, China.
Deng F; Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland.; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.; IDG McGovern Institute for Brain Research, Peking University, Beijing 100871, China.
Li YL; Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland.; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.; IDG McGovern Institute for Brain Research, Peking University, Beijing 100871, China.
Nautiyal KM; Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, USA.
Pascoli V; Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland.; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Lüscher C; Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland.; IDG McGovern Institute for Brain Research, Peking University, Beijing 100871, China.; Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, USA.; Clinic of Neurology, Department of Clinical Neurosciences, Geneva University Hospital, CH-1211 Geneva, Switzerland.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Sep 10; Vol. 373 (6560), pp. 1252-1256. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Synaptic Transmission*
Cocaine-Related Disorders/*metabolism
Receptor, Serotonin, 5-HT1B/*metabolism
Serotonin/*metabolism
Animals ; Cocaine/administration & dosage ; Cocaine-Related Disorders/genetics ; Dopamine/metabolism ; Gene Knock-In Techniques ; Mice ; Mice, Knockout ; Optogenetics ; Receptor, Serotonin, 5-HT1B/deficiency ; Serotonin Plasma Membrane Transport Proteins/metabolism
Czasopismo naukowe
Tytuł :
The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter.
Autorzy :
Plenge P; Laboratory for Membrane Protein Dynamics. Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Yang D; Vollum Institute, Oregon Health & Science University, Portland, OR, USA.
Salomon K; Laboratory for Membrane Protein Dynamics. Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Laursen L; Laboratory for Membrane Protein Dynamics. Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kalenderoglou IE; Laboratory for Membrane Protein Dynamics. Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Newman AH; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse - Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Gouaux E; Vollum Institute, Oregon Health & Science University, Portland, OR, USA.; Howard Hughes Medical Institute, Oregon Health & Science University, Portland, OR, USA.
Coleman JA; Vollum Institute, Oregon Health & Science University, Portland, OR, USA. .; Department of Structural Biology, University of Pittsburgh, Pittsburgh, PA, USA. .
Loland CJ; Laboratory for Membrane Protein Dynamics. Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 20; Vol. 12 (1), pp. 5063. Date of Electronic Publication: 2021 Aug 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antidepressive Agents/*pharmacology
Serotonin Plasma Membrane Transport Proteins/*metabolism
Serotonin Uptake Inhibitors/*pharmacology
Vilazodone Hydrochloride/*pharmacology
Allosteric Regulation/drug effects ; Animals ; Binding Sites ; COS Cells ; Chlorocebus aethiops ; Humans ; Kinetics ; Molecular Dynamics Simulation ; Mutant Proteins/metabolism ; Mutation/genetics ; Serotonin/metabolism ; Serotonin Plasma Membrane Transport Proteins/ultrastructure
Czasopismo naukowe
Tytuł :
Involvement of PKCβI-SERT activity in stress vulnerability of mice exposed to twice-swim stress.
Autorzy :
Ito T; Division of Clinical Sciences and Neuropsychopharmacology, Meijo University Faculty and Graduate School of Pharmacy, 150 Yagotoyama, Tempaku-ku, Nagoya, 468-8503, Japan.
Hiramatsu Y; Division of Clinical Sciences and Neuropsychopharmacology, Meijo University Faculty and Graduate School of Pharmacy, 150 Yagotoyama, Tempaku-ku, Nagoya, 468-8503, Japan.
Mouri A; Department of Regulatory Science for Evaluation & Development of Pharmaceuticals and Devices, Graduate School of Health Science, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
Yoshigai T; Division of Clinical Sciences and Neuropsychopharmacology, Meijo University Faculty and Graduate School of Pharmacy, 150 Yagotoyama, Tempaku-ku, Nagoya, 468-8503, Japan.
Takahashi A; Division of Clinical Sciences and Neuropsychopharmacology, Meijo University Faculty and Graduate School of Pharmacy, 150 Yagotoyama, Tempaku-ku, Nagoya, 468-8503, Japan.
Yoshimi A; Division of Clinical Sciences and Neuropsychopharmacology, Meijo University Faculty and Graduate School of Pharmacy, 150 Yagotoyama, Tempaku-ku, Nagoya, 468-8503, Japan.
Mamiya T; Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya, 468-8503, Japan.
Ozaki N; Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8560, Japan.
Noda Y; Division of Clinical Sciences and Neuropsychopharmacology, Meijo University Faculty and Graduate School of Pharmacy, 150 Yagotoyama, Tempaku-ku, Nagoya, 468-8503, Japan; Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8560, Japan. Electronic address: .
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Źródło :
Neuroscience research [Neurosci Res] 2021 Oct; Vol. 171, pp. 83-91. Date of Electronic Publication: 2021 Jan 15.
Typ publikacji :
Journal Article
MeSH Terms :
Serotonin*/metabolism
Protein Kinase C beta/*metabolism
Serotonin Plasma Membrane Transport Proteins/*metabolism
Stress, Psychological/*metabolism
Animals ; Mice ; Phosphorylation ; Swimming
Czasopismo naukowe
Tytuł :
5-HT Receptors and the Development of New Antidepressants.
Autorzy :
Ślifirski G; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warsaw, Poland.
Król M; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warsaw, Poland.
Turło J; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warsaw, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 20; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antidepressive Agents/*therapeutic use
Depression/*drug therapy
Receptors, Serotonin/*metabolism
Brain/metabolism ; Drug Development/trends ; Humans ; Receptors, Serotonin/drug effects ; Serotonergic Neurons/drug effects ; Serotonergic Neurons/metabolism ; Serotonin/metabolism ; Serotonin Plasma Membrane Transport Proteins/metabolism
Czasopismo naukowe
Tytuł :
Effectiveness of Vortioxetine on Emotional Blunting in Patients with Major Depressive Disorder with inadequate response to SSRI/SNRI treatment.
Autorzy :
Fagiolini A; Division of Psychiatry, Department of Molecular and Developmental Medicine, University of Siena School of Medicine, Italy.
Florea I; H. Lundbeck A/S, Valby, Denmark.
Loft H; H. Lundbeck A/S, Valby, Denmark.
Christensen MC; H. Lundbeck A/S, Valby, Denmark. Electronic address: .
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Źródło :
Journal of affective disorders [J Affect Disord] 2021 Mar 15; Vol. 283, pp. 472-479. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Depressive Disorder, Major*/drug therapy
Serotonin and Noradrenaline Reuptake Inhibitors*/pharmacology
Serotonin and Noradrenaline Reuptake Inhibitors*/therapeutic use
Double-Blind Method ; Humans ; Serotonin Uptake Inhibitors/pharmacology ; Serotonin Uptake Inhibitors/therapeutic use ; Treatment Outcome ; Vortioxetine
Czasopismo naukowe
Tytuł :
Serotonin system gene variants and regional brain volume differences in pediatric OCD.
Autorzy :
Sinopoli VM; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Program in Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
Erdman L; Program in Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Computer Science, University of Toronto, Toronto, ON, Canada.
Burton CL; Program in Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
Easter P; Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI, USA.
Rajendram R; Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Baldwin G; Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI, USA.
Peterman K; Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI, USA.
Coste J; Program in Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
Shaheen SM; Program in Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, 4th floor, Teaching, Research and Wellness (TRW) Building, 3280 Hospital Dr NW, Calgary, AB, T2N 4Z6, ON, Canada.
Hanna GL; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Rosenberg DR; Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI, USA.
Arnold PD; Program in Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada. .; Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, 4th floor, Teaching, Research and Wellness (TRW) Building, 3280 Hospital Dr NW, Calgary, AB, T2N 4Z6, ON, Canada. .; Departments of Psychiatry and Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, ON, Canada. .
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Źródło :
Brain imaging and behavior [Brain Imaging Behav] 2020 Oct; Vol. 14 (5), pp. 1612-1625.
Typ publikacji :
Journal Article
MeSH Terms :
Obsessive-Compulsive Disorder*/diagnostic imaging
Obsessive-Compulsive Disorder*/genetics
Serotonin*
Receptor, Serotonin, 5-HT2C/*genetics
Brain/diagnostic imaging ; Child ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Polymorphism, Single Nucleotide/genetics ; Serotonin Plasma Membrane Transport Proteins
Czasopismo naukowe
Tytuł :
Serotonergic-Muscarinic Interaction within the Prefrontal Cortex as a Novel Target to Reverse Schizophrenia-Related Cognitive Symptoms.
Autorzy :
Cieślik P; Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 31-343 Kraków, Poland.
Radulska A; Department of Medical Laboratory Diagnostics-Fahrenheit Biobank BBMRI.pl, Medical University of Gdańsk, 7 Dębinki Street, 80-211 Gdańsk, Poland.; Biobanking and Biomolecular Resources Research Infrastructure Consortium Poland (BBMRI.pl), 7 Dębinki Street, 80-211 Gdańsk, Poland.
Burnat G; Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 31-343 Kraków, Poland.
Kalinowski L; Department of Medical Laboratory Diagnostics-Fahrenheit Biobank BBMRI.pl, Medical University of Gdańsk, 7 Dębinki Street, 80-211 Gdańsk, Poland.; Biobanking and Biomolecular Resources Research Infrastructure Consortium Poland (BBMRI.pl), 7 Dębinki Street, 80-211 Gdańsk, Poland.; BioTechMed Centre, Department of Mechanics of Materials and Structures, University of Technology, 11/12 Narutowicza Street, 80-223 Gdańsk, Poland.
Wierońska JM; Department of Medical Laboratory Diagnostics-Fahrenheit Biobank BBMRI.pl, Medical University of Gdańsk, 7 Dębinki Street, 80-211 Gdańsk, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 10; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 10.
Typ publikacji :
Journal Article
MeSH Terms :
Cholinergic Agents/*pharmacology
Cognitive Dysfunction/*drug therapy
Prefrontal Cortex/*drug effects
Schizophrenia/*drug therapy
Serotonin Receptor Agonists/*pharmacology
Animals ; Benzamides/pharmacokinetics ; Benzamides/pharmacology ; Benzamides/therapeutic use ; Blood-Brain Barrier/metabolism ; Cholinergic Agents/pharmacokinetics ; Cholinergic Agents/therapeutic use ; Cognitive Dysfunction/etiology ; Dizocilpine Maleate/toxicity ; Male ; Maze Learning ; Mice ; Piperidines/pharmacokinetics ; Piperidines/pharmacology ; Piperidines/therapeutic use ; Prefrontal Cortex/metabolism ; Pyridines/pharmacokinetics ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Pyrimidines/pharmacokinetics ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use ; Receptors, Muscarinic/metabolism ; Receptors, Serotonin/metabolism ; Schizophrenia/complications ; Serotonin Receptor Agonists/pharmacokinetics ; Serotonin Receptor Agonists/therapeutic use ; Thiophenes/pharmacokinetics ; Thiophenes/pharmacology ; Thiophenes/therapeutic use
Czasopismo naukowe

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