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Tytuł :
Short-term efficacy and safety of lasmiditan, a novel 5-HT 1F receptor agonist, for the acute treatment of migraine: a systematic review and meta-analysis.
Autorzy :
Hou M; Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, 400042, P. R. China.
Xing H; Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, 400042, P. R. China.
Li C; Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, 400042, P. R. China.
Wang X; Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, 400042, P. R. China.
Deng D; Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, 400042, P. R. China.
Li J; Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, 400042, P. R. China.
Zhang P; Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, 400042, P. R. China.
Chen J; Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, 400042, P. R. China. .
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Źródło :
The journal of headache and pain [J Headache Pain] 2020 Jun 05; Vol. 21 (1), pp. 66. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Benzamides/*therapeutic use
Migraine Disorders/*diagnosis
Migraine Disorders/*drug therapy
Piperidines/*therapeutic use
Pyridines/*therapeutic use
Receptors, Serotonin/*physiology
Serotonin Receptor Agonists/*therapeutic use
Benzamides/adverse effects ; Dizziness/chemically induced ; Humans ; Nausea/chemically induced ; Piperidines/adverse effects ; Pyridines/adverse effects ; Serotonin Receptor Agonists/adverse effects ; Time Factors ; Treatment Outcome ; Vertigo/chemically induced
Czasopismo naukowe
Tytuł :
Profiling lasmiditan as a treatment option for migraine.
Autorzy :
Curto M; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.; International Mood & Psychotic Disorders Research Consortium, Mailman Research Center, Belmont, MA, USA.; Department of Mental Health, ASL Roma 5, Colleferro (RM), Italy.
Cipolla F; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Cisale GY; Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.
Capi M; Mass Spectrometry Laboratory Unit, Sant'Andrea University Hospital, Rome, Italy.
Spuntarelli V; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Guglielmetti M; Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.; Regional Referral Headache Center, Sant'Andrea University Hospital, Rome, Italy.
Martelletti P; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.; Regional Referral Headache Center, Sant'Andrea University Hospital, Rome, Italy.
Lionetto L; Mass Spectrometry Laboratory Unit, Sant'Andrea University Hospital, Rome, Italy.
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Źródło :
Expert opinion on pharmacotherapy [Expert Opin Pharmacother] 2020 Feb; Vol. 21 (2), pp. 147-153. Date of Electronic Publication: 2019 Nov 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Benzamides/*therapeutic use
Migraine Disorders/*drug therapy
Piperidines/*therapeutic use
Pyridines/*therapeutic use
Serotonin Receptor Agonists/*therapeutic use
Benzamides/adverse effects ; Cardiovascular Diseases/epidemiology ; Humans ; Piperidines/adverse effects ; Pyridines/adverse effects ; Receptors, Serotonin/drug effects ; Serotonin Receptor Agonists/adverse effects
Czasopismo naukowe
Tytuł :
5-hydroxytryptamine 1F Receptor Agonist Induces Mitochondrial Biogenesis and Promotes Recovery from Spinal Cord Injury.
Autorzy :
Simmons EC; Department of Pharmacology and Toxicology, College of Pharmacy (E.C.S., N.E.S., K.H.C., R.G.S.), Department of Neurosciences, College of Medicine (E.C.S., R.G.S.), Southwest Environmental Health Science Center (R.G.S.), and Center for Innovation in Brain Science (R.G.S.), University of Arizona, Tucson, Arizona; and Southern Arizona VA Health Care System, Tucson, Arizona (R.G.S.).
Scholpa NE; Department of Pharmacology and Toxicology, College of Pharmacy (E.C.S., N.E.S., K.H.C., R.G.S.), Department of Neurosciences, College of Medicine (E.C.S., R.G.S.), Southwest Environmental Health Science Center (R.G.S.), and Center for Innovation in Brain Science (R.G.S.), University of Arizona, Tucson, Arizona; and Southern Arizona VA Health Care System, Tucson, Arizona (R.G.S.).
Cleveland KH; Department of Pharmacology and Toxicology, College of Pharmacy (E.C.S., N.E.S., K.H.C., R.G.S.), Department of Neurosciences, College of Medicine (E.C.S., R.G.S.), Southwest Environmental Health Science Center (R.G.S.), and Center for Innovation in Brain Science (R.G.S.), University of Arizona, Tucson, Arizona; and Southern Arizona VA Health Care System, Tucson, Arizona (R.G.S.).
Schnellmann RG; Department of Pharmacology and Toxicology, College of Pharmacy (E.C.S., N.E.S., K.H.C., R.G.S.), Department of Neurosciences, College of Medicine (E.C.S., R.G.S.), Southwest Environmental Health Science Center (R.G.S.), and Center for Innovation in Brain Science (R.G.S.), University of Arizona, Tucson, Arizona; and Southern Arizona VA Health Care System, Tucson, Arizona (R.G.S.) .
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2020 Feb; Vol. 372 (2), pp. 216-223. Date of Electronic Publication: 2019 Nov 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Organelle Biogenesis*
Carbazoles/*chemistry
Fluorobenzenes/*chemistry
Receptors, Serotonin/*metabolism
Serotonin Receptor Agonists/*chemistry
Spinal Cord Injuries/*drug therapy
Animals ; Carbazoles/pharmacology ; Cross-Sectional Studies ; Female ; Fluorobenzenes/pharmacology ; Locomotion/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria/drug effects ; Recovery of Function/drug effects ; Serotonin Receptor Agonists/pharmacology ; Spinal Cord/drug effects ; Time Factors
Czasopismo naukowe
Tytuł :
New Migraine Medication.
Autorzy :
Aschenbrenner DS; Diane S. Aschenbrenner is an assistant professor at Notre Dame of Maryland University in Baltimore. She also coordinates Drug Watch: .
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Źródło :
The American journal of nursing [Am J Nurs] 2020 Feb; Vol. 120 (2), pp. 20-21.
Typ publikacji :
Journal Article
MeSH Terms :
Benzamides/*administration & dosage
Migraine Disorders/*drug therapy
Piperidines/*administration & dosage
Pyridines/*administration & dosage
Serotonin Receptor Agonists/*administration & dosage
Benzamides/adverse effects ; Drug Approval ; Humans ; Piperidines/adverse effects ; Pyridines/adverse effects ; Serotonin Receptor Agonists/adverse effects ; United States ; United States Food and Drug Administration
Czasopismo naukowe
Tytuł :
Uncarialins A-I, Monoterpenoid Indole Alkaloids from Uncaria rhynchophylla as Natural Agonists of the 5-HT 1A Receptor.
Autorzy :
Liang JH; College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease , Dalian Medical University , Dalian 116044 , People's Republic of China.
Luan ZL; College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease , Dalian Medical University , Dalian 116044 , People's Republic of China.
Tian XG; College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease , Dalian Medical University , Dalian 116044 , People's Republic of China.
Zhao WY; College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease , Dalian Medical University , Dalian 116044 , People's Republic of China.
Wang YL; College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease , Dalian Medical University , Dalian 116044 , People's Republic of China.
Sun CP; College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease , Dalian Medical University , Dalian 116044 , People's Republic of China.
Huo XK; College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease , Dalian Medical University , Dalian 116044 , People's Republic of China.
Deng S; College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease , Dalian Medical University , Dalian 116044 , People's Republic of China.
Zhang BJ; College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease , Dalian Medical University , Dalian 116044 , People's Republic of China.
Zhang ZJ; State Key Laboratory of Cognitive Neuroscience and Learning , Beijing Normal University , Beijing 100875 , People's Republic of China.
Ma XC; College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease , Dalian Medical University , Dalian 116044 , People's Republic of China.; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy , Xuzhou Medical University , Xuzhou 221004 , People's Republic of China.
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Źródło :
Journal of natural products [J Nat Prod] 2019 Dec 27; Vol. 82 (12), pp. 3302-3310. Date of Electronic Publication: 2019 Dec 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptor, Serotonin, 5-HT1A/*drug effects
Secologanin Tryptamine Alkaloids/*pharmacology
Serotonin Receptor Agonists/*pharmacology
Uncaria/*chemistry
Animals ; CHO Cells ; Cricetulus ; Molecular Docking Simulation ; Molecular Structure ; Secologanin Tryptamine Alkaloids/chemistry ; Secologanin Tryptamine Alkaloids/isolation & purification ; Serotonin Receptor Agonists/chemistry ; Serotonin Receptor Agonists/isolation & purification ; Spectrum Analysis/methods
Czasopismo naukowe
Tytuł :
[1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HT 7 receptor.
Autorzy :
Romeo G; Dipartimento di Scienze del Farmaco, Università di Catania, viale A. Doria 6, 95125, Catania, Italy. Electronic address: .
Salerno L; Dipartimento di Scienze del Farmaco, Università di Catania, viale A. Doria 6, 95125, Catania, Italy.
Pittalà V; Dipartimento di Scienze del Farmaco, Università di Catania, viale A. Doria 6, 95125, Catania, Italy.
Candido M; Dipartimento di Scienze del Farmaco, Università di Catania, viale A. Doria 6, 95125, Catania, Italy.
Intagliata S; Dipartimento di Scienze del Farmaco, Università di Catania, viale A. Doria 6, 95125, Catania, Italy. Electronic address: .
Amata E; Dipartimento di Scienze del Farmaco, Università di Catania, viale A. Doria 6, 95125, Catania, Italy.
Salmona M; IRCCS-Istituto di Ricerche Farmacologiche 'Mario Negri', via La Masa 19, Milano, 20156, Italy.
Cagnotto A; IRCCS-Istituto di Ricerche Farmacologiche 'Mario Negri', via La Masa 19, Milano, 20156, Italy.
Rescifina A; Dipartimento di Scienze del Farmaco, Università di Catania, viale A. Doria 6, 95125, Catania, Italy.
Floresta G; Dipartimento di Scienze del Farmaco, Università di Catania, viale A. Doria 6, 95125, Catania, Italy.
Modica MN; Dipartimento di Scienze del Farmaco, Università di Catania, viale A. Doria 6, 95125, Catania, Italy.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2019 Dec 01; Vol. 183, pp. 111690. Date of Electronic Publication: 2019 Sep 10.
Typ publikacji :
Journal Article
MeSH Terms :
Pyrimidines/*pharmacology
Receptors, Serotonin/*metabolism
Serotonin Antagonists/*pharmacology
Serotonin Receptor Agonists/*pharmacology
Thiophenes/*pharmacology
Dose-Response Relationship, Drug ; Humans ; Ligands ; Models, Molecular ; Molecular Structure ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Serotonin Antagonists/chemical synthesis ; Serotonin Antagonists/chemistry ; Serotonin Receptor Agonists/chemical synthesis ; Serotonin Receptor Agonists/chemistry ; Structure-Activity Relationship ; Thiophenes/chemical synthesis ; Thiophenes/chemistry
Czasopismo naukowe
Tytuł :
Lasmiditan: First Approval.
Autorzy :
Lamb YN; Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand. .
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Źródło :
Drugs [Drugs] 2019 Dec; Vol. 79 (18), pp. 1989-1996.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Approval*
Benzamides/*pharmacology
Migraine Disorders/*drug therapy
Piperidines/*pharmacology
Pyridines/*pharmacology
Receptors, Serotonin/*metabolism
Serotonin Receptor Agonists/*pharmacology
Benzamides/administration & dosage ; Clinical Trials, Phase III as Topic ; Humans ; Migraine Disorders/metabolism ; Piperidines/administration & dosage ; Pyridines/administration & dosage ; Serotonin Receptor Agonists/administration & dosage
Czasopismo naukowe
Tytuł :
Structure-activity relationships of serotonin 5-HT 7 receptors ligands: A review.
Autorzy :
Thirumaran SL; Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), Normandie Univ, UNICAEN, 14000, Caen, France.
Lepailleur A; Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), Normandie Univ, UNICAEN, 14000, Caen, France.
Rochais C; Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), Normandie Univ, UNICAEN, 14000, Caen, France. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2019 Dec 01; Vol. 183, pp. 111705. Date of Electronic Publication: 2019 Sep 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Receptors, Serotonin/*metabolism
Serotonin Antagonists/*pharmacology
Serotonin Receptor Agonists/*pharmacology
Animals ; Humans ; Ligands ; Serotonin Antagonists/chemistry ; Serotonin Receptor Agonists/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Dose-effect study of the serotonin agonist R-8-OH-DPAT on opioid-induced respiratory depression in blesbok (Damaliscus pygargus philipsi) and impala (Aepyceros melampus).
Autorzy :
Pfitzer S; Murdoch University, School of Veterinary and Life Sciences, Murdoch University, Murdoch, Australia. Electronic address: .
Laubscher L; Wildlife Pharmaceuticals South Africa (Pty) Ltd., Mpumalanga, South Africa; Department of Animal Science, University of Stellenbosch, Stellenbosch, South Africa.
Meyer L; Centre for Veterinary Wildlife Studies and Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Pretoria, South Africa.
Warren K; Murdoch University, School of Veterinary and Life Sciences, Murdoch University, Murdoch, Australia.
Vaughan-Higgins R; Murdoch University, School of Veterinary and Life Sciences, Murdoch University, Murdoch, Australia.
Raath JP; Wildlife Pharmaceuticals South Africa (Pty) Ltd., Mpumalanga, South Africa.
Laurence M; Murdoch University, School of Veterinary and Life Sciences, Murdoch University, Murdoch, Australia.
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Źródło :
Veterinary anaesthesia and analgesia [Vet Anaesth Analg] 2019 Nov; Vol. 46 (6), pp. 796-806. Date of Electronic Publication: 2019 Jul 06.
Typ publikacji :
Journal Article; Randomized Controlled Trial, Veterinary
MeSH Terms :
Antelopes*
8-Hydroxy-2-(di-n-propylamino)tetralin/*pharmacology
Analgesics, Opioid/*adverse effects
Etorphine/*adverse effects
Respiratory Insufficiency/*veterinary
Serotonin Receptor Agonists/*pharmacology
8-Hydroxy-2-(di-n-propylamino)tetralin/administration & dosage ; Analgesics, Opioid/pharmacology ; Animals ; Blood Pressure/drug effects ; Cross-Over Studies ; Dose-Response Relationship, Drug ; Etorphine/pharmacology ; Female ; Heart Rate/drug effects ; Oxygen/blood ; Respiratory Insufficiency/chemically induced ; Respiratory Insufficiency/drug therapy ; Serotonin Receptor Agonists/administration & dosage
Czasopismo naukowe
Tytuł :
Novel Medications for the Treatment of Migraine.
Autorzy :
Ceriani CEJ; Jefferson Headache Center, Thomas Jefferson University, Philadelphia, PA, USA.
Wilhour DA; Jefferson Headache Center, Thomas Jefferson University, Philadelphia, PA, USA.
Silberstein SD; Jefferson Headache Center, Thomas Jefferson University, Philadelphia, PA, USA.
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Źródło :
Headache [Headache] 2019 Oct; Vol. 59 (9), pp. 1597-1608. Date of Electronic Publication: 2019 Sep 26.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Analgesics/*therapeutic use
Antibodies, Monoclonal/*therapeutic use
Calcitonin Gene-Related Peptide Receptor Antagonists/*therapeutic use
Migraine Disorders/*drug therapy
Receptors, Serotonin/*drug effects
Serotonin Receptor Agonists/*therapeutic use
Analgesics/pharmacology ; Benzamides/therapeutic use ; Calcitonin Gene-Related Peptide/physiology ; Calcitonin Gene-Related Peptide Receptor Antagonists/pharmacology ; Clinical Trials as Topic ; Contraindications, Drug ; Drug Approval ; Humans ; Migraine Disorders/physiopathology ; Piperidines/therapeutic use ; Pyridines/therapeutic use ; Receptors, Calcitonin Gene-Related Peptide/drug effects ; Receptors, Calcitonin Gene-Related Peptide/physiology ; Receptors, Serotonin/physiology ; Serotonin Receptor Agonists/pharmacology ; United States ; United States Food and Drug Administration ; Vasoconstriction/drug effects ; Vasoconstrictor Agents/adverse effects ; Vasoconstrictor Agents/therapeutic use
Czasopismo naukowe
Tytuł :
Weight Loss in Women Taking Flibanserin for Hypoactive Sexual Desire Disorder (HSDD): Insights Into Potential Mechanisms.
Autorzy :
Simon JA; Department of Obstetrics and Gynecology, George Washington University School of Medicine and IntimMedicine Specialists, Washington, DC, USA.
Kingsberg SA; Departments of Psychiatry and Reproductive Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Goldstein I; Sexual Medicine, Alvarado Hospital, San Diego, CA, USA.
Kim NN; Institute for Sexual Medicine, San Diego, CA, USA. Electronic address: .
Hakim B; Sprout Pharmaceuticals, Inc., Raleigh, NC, USA.
Millheiser L; Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA.
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Źródło :
Sexual medicine reviews [Sex Med Rev] 2019 Oct; Vol. 7 (4), pp. 575-586. Date of Electronic Publication: 2019 Jun 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Benzimidazoles/*adverse effects
Serotonin Antagonists/*adverse effects
Serotonin Receptor Agonists/*adverse effects
Sexual Dysfunctions, Psychological/*drug therapy
Weight Loss/*drug effects
Arousal/drug effects ; Benzimidazoles/pharmacology ; Energy Intake/drug effects ; Female ; Humans ; Libido/drug effects ; Serotonin Antagonists/pharmacology ; Serotonin Receptor Agonists/pharmacology
Czasopismo naukowe
Tytuł :
The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT 6 Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment.
Autorzy :
Latacz G; Department of Technology and Biotechnology of Drugs, Medical College, Jagiellonian University, Medyczna 9, PL 30-688 Cracow, Poland.
Lubelska A; Department of Technology and Biotechnology of Drugs, Medical College, Jagiellonian University, Medyczna 9, PL 30-688 Cracow, Poland.
Jastrzębska-Więsek M; Department of Clinical Pharmacy, Medical College, Jagiellonian University, Medyczna 9, PL 30-688 Cracow, Poland.
Partyka A; Department of Clinical Pharmacy, Medical College, Jagiellonian University, Medyczna 9, PL 30-688 Cracow, Poland.
Marć MA; Department of Technology and Biotechnology of Drugs, Medical College, Jagiellonian University, Medyczna 9, PL 30-688 Cracow, Poland.
Satała G; Department of Medicinal Chemistry Institute of Pharmacology, Polish Academy of Science, Smętna 12, PL 31-343 Cracow, Poland.
Wilczyńska D; Department of Clinical Pharmacy, Medical College, Jagiellonian University, Medyczna 9, PL 30-688 Cracow, Poland.
Kotańska M; Department of Pharmacodynamics, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9, PL 30-688 Cracow, Poland.
Więcek M; Department of Technology and Biotechnology of Drugs, Medical College, Jagiellonian University, Medyczna 9, PL 30-688 Cracow, Poland.
Kamińska K; Department of Technology and Biotechnology of Drugs, Medical College, Jagiellonian University, Medyczna 9, PL 30-688 Cracow, Poland.
Wesołowska A; Department of Clinical Pharmacy, Medical College, Jagiellonian University, Medyczna 9, PL 30-688 Cracow, Poland.
Kieć-Kononowicz K; Department of Technology and Biotechnology of Drugs, Medical College, Jagiellonian University, Medyczna 9, PL 30-688 Cracow, Poland.
Handzlik J; Department of Technology and Biotechnology of Drugs, Medical College, Jagiellonian University, Medyczna 9, PL 30-688 Cracow, Poland. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Jul 12; Vol. 20 (14). Date of Electronic Publication: 2019 Jul 12.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, Serotonin/*chemistry
Serotonin Receptor Agonists/*chemistry
Serotonin Receptor Agonists/*pharmacology
Triazines/*chemistry
Triazines/*pharmacology
Animals ; Cognitive Dysfunction/drug therapy ; Dopamine/chemistry ; Dopamine/pharmacology ; HEK293 Cells ; Humans ; Ligands ; Male ; Memory/drug effects ; Metabolic Networks and Pathways ; Molecular Structure ; Rats ; Receptors, Serotonin/metabolism ; Serotonin/chemistry ; Serotonin/pharmacology ; Serotonin Receptor Agonists/therapeutic use
Czasopismo naukowe
Tytuł :
Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT 7 receptor low-basicity agonists, potential neuropathic painkillers.
Autorzy :
Hogendorf AS; Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.
Hogendorf A; Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.
Popiołek-Barczyk K; Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.
Ciechanowska A; Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.
Mika J; Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.
Satała G; Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.
Walczak M; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland.
Latacz G; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland.
Handzlik J; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland.
Kieć-Kononowicz K; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland.
Ponimaskin E; Center of Physiology, Hannover Medical School, 1 Carl-Neuberg Street, 30625 Hannover, Germany.
Schade S; Center of Physiology, Hannover Medical School, 1 Carl-Neuberg Street, 30625 Hannover, Germany.
Zeug A; Center of Physiology, Hannover Medical School, 1 Carl-Neuberg Street, 30625 Hannover, Germany.
Bijata M; Center of Physiology, Hannover Medical School, 1 Carl-Neuberg Street, 30625 Hannover, Germany; Laboratory of Cell Biophysics, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093 Warszawa, Poland.
Kubicki M; Adam Mickiewicz University, Faculty of Chemistry, 89b Umultowska Street, 61-614 Poznań, Poland.
Kurczab R; Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.
Lenda T; Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.
Staroń J; Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.
Bugno R; Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.
Duszyńska B; Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland.
Pilarski B; CERKO, 96/98 Zwycięstwa Avenue, 81-525 Gdynia, Poland.
Bojarski AJ; Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 30-343 Kraków, Poland. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2019 May 15; Vol. 170, pp. 261-275. Date of Electronic Publication: 2019 Mar 11.
Typ publikacji :
Journal Article
MeSH Terms :
Imidazoles/*chemistry
Imidazoles/*pharmacokinetics
Indoles/*chemistry
Indoles/*pharmacokinetics
Neuralgia/*drug therapy
Serotonin Receptor Agonists/*chemistry
Serotonin Receptor Agonists/*pharmacokinetics
Administration, Oral ; Analgesics/administration & dosage ; Analgesics/chemistry ; Analgesics/pharmacokinetics ; Analgesics/pharmacology ; Animals ; HEK293 Cells ; Halogenation ; Humans ; Imidazoles/administration & dosage ; Imidazoles/therapeutic use ; Indoles/administration & dosage ; Indoles/therapeutic use ; Male ; Mice ; Models, Molecular ; Neuralgia/metabolism ; Receptors, Serotonin/metabolism ; Serotonin Receptor Agonists/administration & dosage ; Serotonin Receptor Agonists/therapeutic use
Czasopismo naukowe
Tytuł :
Structural insight into the serotonin (5-HT) receptor family by molecular docking, molecular dynamics simulation and systems pharmacology analysis.
Autorzy :
Wang YQ; School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.; Chongqing Key Laboratory of Medicinal Chemistry and Molecular Pharmacology, Chongqing, 400054, China.; Chongqing Key Laboratory of Targeted Drug Screening and Effect Evaluation, Chongqing, 400054, China.; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; NIH National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Lin WW; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; NIH National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Wu N; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; NIH National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Wang SY; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; NIH National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Chen MZ; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; NIH National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Lin ZH; School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.; Chongqing Key Laboratory of Medicinal Chemistry and Molecular Pharmacology, Chongqing, 400054, China.; Chongqing Key Laboratory of Targeted Drug Screening and Effect Evaluation, Chongqing, 400054, China.
Xie XQ; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, 15261, USA. .; NIH National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, PA, 15261, USA. .; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA. .; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA. .
Feng ZW; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, 15261, USA. .; NIH National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, PA, 15261, USA. .; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA. .
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Źródło :
Acta pharmacologica Sinica [Acta Pharmacol Sin] 2019 Sep; Vol. 40 (9), pp. 1138-1156. Date of Electronic Publication: 2019 Feb 27.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, Serotonin/*metabolism
Serotonin Antagonists/*metabolism
Serotonin Receptor Agonists/*metabolism
Binding Sites ; Humans ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Pharmacology/methods ; Receptors, Serotonin/chemistry ; Serotonin Antagonists/chemistry ; Serotonin Receptor Agonists/chemistry
Czasopismo naukowe
Tytuł :
Effect of a rescue or recurrence dose of lasmiditan on efficacy and safety in the acute treatment of migraine: findings from the phase 3 trials (SAMURAI and SPARTAN).
Autorzy :
Loo LS; Eli Lilly and Company, Corporate Center, Indianapolis, IN, 46285, USA. .
Plato BM; Norton Neuroscience Institute, 3991 Dutchmans Ln #310, Louisville, KY, 40207, USA.
Turner IM; The Center for Headache Care and Research, Island Neurological Associates PC, An affiliate of ProHealthcare, 824 Old Country Rd, Plainview, NY, 11803, USA.
Case MG; Eli Lilly and Company, Corporate Center, Indianapolis, IN, 46285, USA.
Raskin J; Eli Lilly and Company, Corporate Center, Indianapolis, IN, 46285, USA.
Dowsett SA; Eli Lilly and Company, Corporate Center, Indianapolis, IN, 46285, USA.
Krege JH; Eli Lilly and Company, Corporate Center, Indianapolis, IN, 46285, USA.
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Źródło :
BMC neurology [BMC Neurol] 2019 Aug 13; Vol. 19 (1), pp. 191. Date of Electronic Publication: 2019 Aug 13.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial
MeSH Terms :
Benzamides/*administration & dosage
Migraine Disorders/*drug therapy
Piperidines/*administration & dosage
Pyridines/*administration & dosage
Serotonin Receptor Agonists/*administration & dosage
Adult ; Benzamides/adverse effects ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Piperidines/adverse effects ; Pyridines/adverse effects ; Recurrence ; Serotonin Receptor Agonists/adverse effects
Czasopismo naukowe
Tytuł :
Low activation threshold of juxtapulmonary capillary (J) receptors of the lung.
Autorzy :
Anand A; Exertional Breathlessness Studies Laboratory, Vallabhbhai Patel Chest Institute, Delhi University, Delhi, 110007, India. Electronic address: .
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Źródło :
Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2019 Aug; Vol. 266, pp. 66-72. Date of Electronic Publication: 2019 May 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Capillaries*
Biguanides/*pharmacology
Lung/*physiology
Pulmonary Alveoli/*physiology
Reflex/*physiology
Respiratory Rate/*physiology
Sensory Receptor Cells/*physiology
Serotonin Receptor Agonists/*pharmacology
Animals ; Biguanides/administration & dosage ; Cats ; Lung/drug effects ; Lung/innervation ; Pulmonary Alveoli/drug effects ; Pulmonary Alveoli/innervation ; Reflex/drug effects ; Respiratory Rate/drug effects ; Sensory Receptor Cells/drug effects ; Serotonin Receptor Agonists/administration & dosage
Czasopismo naukowe
Tytuł :
Effects of 5-HT 1 and 5-HT 2 Receptor Agonists on Electromagnetic Field-Induced Analgesia in Rats.
Autorzy :
Ozdemir E; Departments of Physiology, School of Medicine, Cumhuriyet University, Sivas, Turkey.
Demirkazik A; Departments of Biophysics, School of Medicine, Cumhuriyet University, Sivas, Turkey.
Taskıran AS; Departments of Physiology, School of Medicine, Cumhuriyet University, Sivas, Turkey.
Arslan G; Departments of Physiology, School of Medicine, Ondokuz Mayıs University, Samsun, Turkey.
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Źródło :
Bioelectromagnetics [Bioelectromagnetics] 2019 Jul; Vol. 40 (5), pp. 319-330. Date of Electronic Publication: 2019 May 31.
Typ publikacji :
Journal Article
MeSH Terms :
Analgesia*
Electromagnetic Fields*
Amphetamines/*pharmacology
Serotonin Receptor Agonists/*pharmacology
Amphetamines/chemistry ; Animals ; Male ; Pain Management ; Rats, Wistar ; Serotonin/metabolism ; Serotonin Receptor Agonists/chemistry
Czasopismo naukowe
Tytuł :
The need for new acutely acting antimigraine drugs: moving safely outside acute medication overuse.
Autorzy :
van Hoogstraten WS; Dept. of Neuroscience Erasmus University Medical Centre, PO Box 2040, 3000, CA, Rotterdam, The Netherlands.
MaassenVanDenBrink A; Div. of Pharmacology, Dept. of Internal Medicine, Erasmus University Medical Centre, PO Box 2040, 3000, CA, Rotterdam, The Netherlands. .
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Źródło :
The journal of headache and pain [J Headache Pain] 2019 May 16; Vol. 20 (1), pp. 54. Date of Electronic Publication: 2019 May 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Calcitonin Gene-Related Peptide Receptor Antagonists/*therapeutic use
Headache Disorders, Secondary/*chemically induced
Headache Disorders, Secondary/*prevention & control
Migraine Disorders/*drug therapy
Serotonin Receptor Agonists/*therapeutic use
Animals ; Calcitonin Gene-Related Peptide Receptor Antagonists/adverse effects ; Calcitonin Gene-Related Peptide Receptor Antagonists/pharmacology ; Humans ; Prescription Drug Overuse/prevention & control ; Serotonin Receptor Agonists/adverse effects ; Serotonin Receptor Agonists/pharmacology
Czasopismo naukowe
Tytuł :
Pharmacokinetics and bioavailability after intramuscular injection of the 5-HT 1A serotonin agonist R-8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in domestic goats (Capra aegagrus hircus).
Autorzy :
Pfitzer S; School of Veterinary and Life Sciences, Murdoch University, Murdoch, Western Australia, Australia.
Woodward AP; Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria, Australia.
Laubscher L; Wildlife Pharmaceuticals South Africa (Pty) Ltd., White River, South Africa.; Department of Animal Science, University of Stellenbosch, Matieland, South Africa.
Warren K; School of Veterinary and Life Sciences, Murdoch University, Murdoch, Western Australia, Australia.
Vaughan-Higgins R; School of Veterinary and Life Sciences, Murdoch University, Murdoch, Western Australia, Australia.
Raath JP; Wildlife Pharmaceuticals South Africa (Pty) Ltd., White River, South Africa.
Laurence M; School of Veterinary and Life Sciences, Murdoch University, Murdoch, Western Australia, Australia.
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Źródło :
Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2019 May; Vol. 42 (3), pp. 251-257. Date of Electronic Publication: 2019 Jan 17.
Typ publikacji :
Journal Article
MeSH Terms :
8-Hydroxy-2-(di-n-propylamino)tetralin/*pharmacokinetics
Serotonin Receptor Agonists/*pharmacokinetics
8-Hydroxy-2-(di-n-propylamino)tetralin/administration & dosage ; 8-Hydroxy-2-(di-n-propylamino)tetralin/blood ; Animals ; Biological Availability ; Female ; Goats/blood ; Goats/metabolism ; Injections, Intramuscular/veterinary ; Serotonin Receptor Agonists/administration & dosage ; Serotonin Receptor Agonists/blood
Czasopismo naukowe
Tytuł :
Cytochrome P450 enzymes contribute to the metabolism of LSD to nor-LSD and 2-oxo-3-hydroxy-LSD: Implications for clinical LSD use.
Autorzy :
Luethi D; Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Hoener MC; Neuroscience Research, pRED, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Krähenbühl S; Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Liechti ME; Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland. Electronic address: .
Duthaler U; Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2019 Jun; Vol. 164, pp. 129-138. Date of Electronic Publication: 2019 Apr 11.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochrome P-450 Enzyme System/*metabolism
Lysergic Acid Diethylamide/*analogs & derivatives
Lysergic Acid Diethylamide/*metabolism
Microsomes, Liver/*metabolism
Serotonin Receptor Agonists/*metabolism
Animals ; Drug Interactions/physiology ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/pharmacology ; HEK293 Cells ; Humans ; Lysergic Acid Diethylamide/pharmacology ; Mice ; Microsomes, Liver/drug effects ; NIH 3T3 Cells ; Serotonin Receptor Agonists/pharmacology
Czasopismo naukowe

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