Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.
Autorzy:
Drayman N; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA. . DeMarco JK; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA. Jones KA; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Department of Chemistry, The University of Chicago, Chicago, IL, USA. Azizi SA; Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.; Department of Chemistry, The University of Chicago, Chicago, IL, USA. Froggatt HM; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France.; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA. Tan K; Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, USA. Maltseva NI; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, USA. Chen S; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Cellular Screening Center, The University of Chicago, Chicago, IL, USA. Nicolaescu V; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA. Dvorkin S; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA. Furlong K; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA. Kathayat RS; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Department of Chemistry, The University of Chicago, Chicago, IL, USA. Firpo MR; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA.; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA. Mastrodomenico V; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA. Bruce EA; Cellular Screening Center, The University of Chicago, Chicago, IL, USA.; Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, USA. Schmidt MM; Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, USA. Jedrzejczak R; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, USA. Muñoz-Alía MÁ; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA. Schuster B; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA. Nair V; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA. Han KY; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA.; Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA. O'Brien A; Department of Pharmaceutical Sciences, College of Pharmacy, Biophysics Core at Research Resources Center, University of Illinois at Chicago, Chicago, IL, USA.; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA. Tomatsidou A; Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA. Meyer B; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France. Vignuzzi M; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, USA.; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France. Missiakas D; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA. Botten JW; Cellular Screening Center, The University of Chicago, Chicago, IL, USA.; Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, VT, USA. Brooke CB; Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. Lee H; Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Pharmaceutical Sciences, College of Pharmacy, Biophysics Core at Research Resources Center, University of Illinois at Chicago, Chicago, IL, USA. Baker SC; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France.; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA.; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA. Mounce BC; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France.; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA. Heaton NS; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France.; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA. SeversonWE; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA. Palmer KE; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA. Dickinson BC; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Department of Chemistry, The University of Chicago, Chicago, IL, USA. Joachimiak A; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, USA.; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA. Randall G; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA. Tay S; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA. .; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2021 Aug 20; Vol. 373 (6557), pp. 931-936. Date of Electronic Publication: 2021 Jul 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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