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    Wyświetlanie 1-4 z 4
    Tytuł:
    Multi-state design of flexible proteins predicts sequences optimal for conformational change.
    Autorzy:
    Sauer MF; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
    Sevy AM; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
    Crowe JE Jr; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
    Meiler J; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America.
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    Źródło:
    PLoS computational biology [PLoS Comput Biol] 2020 Feb 07; Vol. 16 (2), pp. e1007339. Date of Electronic Publication: 2020 Feb 07 (Print Publication: 2020).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Proteins/*chemistry
    Algorithms ; Protein Conformation ; Thermodynamics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Immune repertoire fingerprinting by principal component analysis reveals shared features in subject groups with common exposures.
    Autorzy:
    Sevy AM; Chemical & Physical Biology Program, Vanderbilt University, Nashville, TN, 37235, USA.; Center for Structural Biology, Vanderbilt University, Nashville, TN, 37235, USA.; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
    Soto C; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
    Bombardi RG; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
    Meiler J; Chemical & Physical Biology Program, Vanderbilt University, Nashville, TN, 37235, USA.; Center for Structural Biology, Vanderbilt University, Nashville, TN, 37235, USA.; Department of Chemistry, Vanderbilt University, Nashville, TN, 37235, USA.
    Crowe JE Jr; Chemical & Physical Biology Program, Vanderbilt University, Nashville, TN, 37235, USA. .; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. .; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. .; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. .
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    Źródło:
    BMC bioinformatics [BMC Bioinformatics] 2019 Dec 04; Vol. 20 (1), pp. 629. Date of Electronic Publication: 2019 Dec 04.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Principal Component Analysis*
    Antibodies/*genetics
    Adult ; Cohort Studies ; Fetal Blood/immunology ; HIV Infections/blood ; HIV Infections/immunology ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Influenza, Human/blood ; Influenza, Human/immunology ; Middle Aged ; Vaccination
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Integrating linear optimization with structural modeling to increase HIV neutralization breadth.
    Autorzy:
    Sevy AM; Center for Structural Biology, Vanderbilt University, Nashville, TN, United States of America.
    Panda S; Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States of America.
    Crowe JE Jr; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, United States of America.
    Meiler J; Center for Structural Biology, Vanderbilt University, Nashville, TN, United States of America.; Department of Chemistry, Vanderbilt University, Nashville, TN, United States of America.
    Vorobeychik Y; Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States of America.
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    Źródło:
    PLoS computational biology [PLoS Comput Biol] 2018 Feb 16; Vol. 14 (2), pp. e1005999. Date of Electronic Publication: 2018 Feb 16 (Print Publication: 2018).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
    MeSH Terms:
    Computational Biology*
    Antibodies, Neutralizing/*immunology
    Epitopes/*immunology
    HIV Antibodies/*immunology
    HIV Infections/*immunology
    Algorithms ; Amino Acid Motifs ; HIV-1 ; Humans ; Linear Models ; Machine Learning ; Regression Analysis ; Software ; Support Vector Machine
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Design of Protein Multi-specificity Using an Independent Sequence Search Reduces the Barrier to Low Energy Sequences.
    Autorzy:
    Sevy AM; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.
    Jacobs TM; Department of Biochemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Crowe JE Jr; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
    Meiler J; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America.
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    Źródło:
    PLoS computational biology [PLoS Comput Biol] 2015 Jul 06; Vol. 11 (7), pp. e1004300. Date of Electronic Publication: 2015 Jul 06 (Print Publication: 2015).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Models, Chemical*
    Models, Molecular*
    Protein Engineering/*methods
    Proteins/*chemistry
    Proteins/*ultrastructure
    Sequence Analysis, Protein/*methods
    Algorithms ; Amino Acid Sequence ; Binding Sites ; Computer Simulation ; Directed Molecular Evolution/methods ; Drug Design ; Energy Transfer ; Molecular Sequence Data ; Protein Binding ; Proteins/genetics ; Structure-Activity Relationship ; Thermodynamics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-4 z 4

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