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Wyświetlanie 1-14 z 14
Tytuł :
Long-QT mutation p.K557E-Kv7.1: dominant-negative suppression of IKs, but preserved cAMP-dependent up-regulation.
Autorzy :
Spätjens, Roel L.H.M.G.
Bébarová, Markéta
Seyen, Sandrine R.M.
Lentink, Viola
Jongbloed, Roselie J.
Arens, Yvonne H.J.M.
Heijman, Jordi
Volders, Paul G.A.
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Temat :
LONG QT syndrome
GENETIC mutation
CYCLIC adenylic acid
GENETIC regulation
CARDIAC arrest
TACHYARRHYTHMIAS
EXERCISE
ADRENERGIC mechanisms
Źródło :
Cardiovascular Research; Oct2014, Vol. 104 Issue 1, p216-225, 10p
Czasopismo naukowe
Tytuł :
Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives.
Autorzy :
Volvert, Marie-Laure
Seyen, Sandrine
Piette, Marie
Evrard, Brigitte
Gangolf, Marjorie
Plumier, Jean-Christophe
Bettendorff, Lucien
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Temat :
PHARMACODYNAMICS
DRUG derivatives
VITAMIN B1
ALKALINE phosphatase
ABSORPTION (Physiology)
Źródło :
BMC Pharmacology; 2008, Vol. 8, Special section p1-11, 11p, 1 Diagram, 5 Graphs
Czasopismo naukowe
Tytuł :
Mutation location and IKs regulation in the arrhythmic risk of long QT syndrome type 1: the importance of the KCNQ1 S6 region.
Autorzy :
Schwartz PJ; Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin, Via Pier Lombardo, 22, 20135 Milan, Italy.; Istituto Auxologico Italiano, IRCCS, Laboratory of Cardiovascular Genetics, via Zucchi 18, 20095 Cusano Milanino, MI, Italy.
Moreno C; Department of Cardiology, CARIM, Maastricht University Medical Center, PO Box 5800, 6202 Maastricht, The Netherlands.; Molecular Neurophysiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Dr., Bethesda, MD 20892-3701, USA.
Kotta MC; Istituto Auxologico Italiano, IRCCS, Laboratory of Cardiovascular Genetics, via Zucchi 18, 20095 Cusano Milanino, MI, Italy.
Pedrazzini M; Istituto Auxologico Italiano, IRCCS, Laboratory of Cardiovascular Genetics, via Zucchi 18, 20095 Cusano Milanino, MI, Italy.
Crotti L; Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin, Via Pier Lombardo, 22, 20135 Milan, Italy.; Istituto Auxologico Italiano, IRCCS, Laboratory of Cardiovascular Genetics, via Zucchi 18, 20095 Cusano Milanino, MI, Italy.; Department of Cardiovascular, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, San Luca Hospital, Piazzale Brescia 20, 20149 Milan, Italy.; Department of Medicine and Surgery, University of Milano-Bicocca, Piazza dell'Ateneo Nuovo, 1, 20126 Milano, Italy.
Dagradi F; Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin, Via Pier Lombardo, 22, 20135 Milan, Italy.
Castelletti S; Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin, Via Pier Lombardo, 22, 20135 Milan, Italy.
Haugaa KH; ProCardio center for innovation, Department of Cardiology, Oslo University Hospital, Postboks 4950 Nydalen, 0424 Oslo, Norway.; University of Oslo, Postboks 1171, Blindern 0318 Oslo, Norway.
Denjoy I; Centre de Référence Maladies Cardiaques Héréditaires, Filière Cardiogen, Département de Rythmologie, Groupe Hospitalier Bichat-Claude Bernard, 46 Rue Henri -Huchard, 75877 PARIS Cedex 18, France.
Shkolnikova MA; Pirogov Russian National Research Medical University, Research and Clinical Institute for Pediatrics named after Academician Yuri Veltischev, Centre for Cardiac Arrhythmia, Taldomskaya 2, 125412 Moscow, Russian Federation.
Brink PA; Department of Internal Medicine, Stellenbosch University, Tygerberg 7505, South Africa.
Heradien MJ; Department of Internal Medicine, Stellenbosch University, Tygerberg 7505, South Africa.
Seyen SRM; Department of Cardiology, CARIM, Maastricht University Medical Center, PO Box 5800, 6202 Maastricht, The Netherlands.
Spätjens RLHMG; Department of Cardiology, CARIM, Maastricht University Medical Center, PO Box 5800, 6202 Maastricht, The Netherlands.
Spazzolini C; Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin, Via Pier Lombardo, 22, 20135 Milan, Italy.
Volders PGA; Department of Cardiology, CARIM, Maastricht University Medical Center, PO Box 5800, 6202 Maastricht, The Netherlands.
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Źródło :
European heart journal [Eur Heart J] 2021 Sep 10. Date of Electronic Publication: 2021 Sep 10.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Dominant-negative control of cAMP-dependent IKs upregulation in human long-QT syndrome type 1.
Autorzy :
Heijman J; Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands.
Spätjens RL
Seyen SR
Lentink V
Kuijpers HJ
Boulet IR
de Windt LJ
David M
Volders PG
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Źródło :
Circulation research [Circ Res] 2012 Jan 20; Vol. 110 (2), pp. 211-9. Date of Electronic Publication: 2011 Nov 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, Dominant*
Mutation*
Cyclic AMP/*metabolism
KCNQ1 Potassium Channel/*genetics
KCNQ1 Potassium Channel/*metabolism
Myocytes, Cardiac/*metabolism
Romano-Ward Syndrome/*genetics
Romano-Ward Syndrome/*metabolism
Adrenergic beta-Agonists/pharmacology ; Alanine ; Animals ; Aspartic Acid ; Blotting, Western ; CHO Cells ; Computer Simulation ; Cricetinae ; Cricetulus ; Dogs ; Genetic Predisposition to Disease ; Heterozygote ; Humans ; Immunoprecipitation ; KCNQ1 Potassium Channel/drug effects ; Membrane Potentials ; Models, Cardiovascular ; Mutagenesis, Site-Directed ; Myocytes, Cardiac/drug effects ; Phenotype ; Phosphorylation ; Potassium Channels, Voltage-Gated/genetics ; Potassium Channels, Voltage-Gated/metabolism ; Protein Processing, Post-Translational ; Romano-Ward Syndrome/physiopathology ; Time Factors ; Transfection
Czasopismo naukowe
    Wyświetlanie 1-14 z 14

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