Identification of a hyperinflammatory sepsis phenotype using protein biomarker and clinical data in the ProCESS randomized trial.
Autorzy:
DeMerle KM; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Pittsburgh, PA, USA.; Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Kennedy JN; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Pittsburgh, PA, USA.; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Chang CH; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Pittsburgh, PA, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Delucchi K; Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA. Huang DT; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Pittsburgh, PA, USA.; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Multidisciplinary Acute Care Research Organization (MACRO), Pittsburgh, PA, USA. Kravitz MS; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. Shapiro NI; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA, USA. Yealy DM; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Angus DC; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Pittsburgh, PA, USA.; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Calfee CS; Division of Pulmonary and Critical Care Medicine, Department of Medicine and Anesthesia, University of California San Francisco, San Francisco, CA, USA. SeymourCW; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Pittsburgh, PA, USA. .; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA. .; Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, USA. .; Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, 3459 Fifth Avenue, NW628, Pittsburgh, PA, 15213, USA. .
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2024 Mar 14; Vol. 14 (1), pp. 6234. Date of Electronic Publication: 2024 Mar 14.
The UPMC OPTIMISE-C19 (OPtimizing Treatment and Impact of Monoclonal antIbodieS through Evaluation for COVID-19) trial: a structured summary of a study protocol for an open-label, pragmatic, comparative effectiveness platform trial with response-adaptive randomization.
Autorzy:
Huang DT; Department of Emergency Medicine, University of Pittsburgh School of Medicine, 606B Scaife Hall, Pittsburgh, PA, 15213, USA. .; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. . McCreary EK; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Bariola JR; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Wadas RJ; Department of Emergency Medicine, University of Pittsburgh School of Medicine, 606B Scaife Hall, Pittsburgh, PA, 15213, USA. Kip KE; Clinical Analytics, UPMC, Pittsburgh, PA, USA. Marroquin OC; Clinical Analytics, UPMC, Pittsburgh, PA, USA. Koscumb S; Clinical Analytics, UPMC, Pittsburgh, PA, USA. Collins K; Clinical Analytics, UPMC, Pittsburgh, PA, USA. Shovel JA; Wolff Center, UPMC, Pittsburgh, PA, USA. Schmidhofer M; Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Wisniewski MK; Wolff Center, UPMC, Pittsburgh, PA, USA. Sullivan C; UPMC Health System Office of Healthcare Innovation, Pittsburgh, PA, USA. Yealy DM; Department of Emergency Medicine, University of Pittsburgh School of Medicine, 606B Scaife Hall, Pittsburgh, PA, 15213, USA. Axe M; Department of Emergency Medicine, University of Pittsburgh School of Medicine, 606B Scaife Hall, Pittsburgh, PA, 15213, USA. Nace DA; Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Haidar G; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Khadem T; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Linstrum K; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; UPMC Health System Office of Healthcare Innovation, Pittsburgh, PA, USA. Snyder GM; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. SeymourCW; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; UPMC Health System Office of Healthcare Innovation, Pittsburgh, PA, USA. Montgomery SK; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; UPMC Health System Office of Healthcare Innovation, Pittsburgh, PA, USA. McVerry BJ; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Berry L; Berry Consultants, Austin, TX, USA. Berry S; Berry Consultants, Austin, TX, USA. Meyers R; Department of Emergency Medicine, University of Pittsburgh School of Medicine, 606B Scaife Hall, Pittsburgh, PA, 15213, USA. Weissman A; Department of Emergency Medicine, University of Pittsburgh School of Medicine, 606B Scaife Hall, Pittsburgh, PA, 15213, USA. Peck-Palmer OM; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Wells A; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Bart R; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; UPMC Health Services Division, Pittsburgh, PA, USA. Albin DL; UPMC Supply Chain Management/HC Pharmacy, Pittsburgh, PA, USA. Minnier T; Wolff Center, UPMC, Pittsburgh, PA, USA. Angus DC; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; UPMC Health System Office of Healthcare Innovation, Pittsburgh, PA, USA.
Pokaż więcej
Źródło:
Trials [Trials] 2021 May 25; Vol. 22 (1), pp. 363. Date of Electronic Publication: 2021 May 25.
Impact of Bamlanivimab Monoclonal Antibody Treatment on Hospitalization and Mortality Among Nonhospitalized Adults With Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
Autorzy:
Bariola JR; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. McCreary EK; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Wadas RJ; Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Kip KE; Clinical Analytics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. Marroquin OC; Clinical Analytics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. Minnier T; Wolff Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. Koscumb S; Clinical Analytics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. Collins K; Clinical Analytics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. Schmidhofer M; Division of Cardiology, Dept of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Shovel JA; Wolff Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. Wisniewski MK; Wolff Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. Sullivan C; UPMC Health System Office of Healthcare Innovation, Pittsburgh, Pennsylvania, USA. Yealy DM; Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Nace DA; Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Huang DT; Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Clinical Research Investigation and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Haidar G; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Khadem T; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Linstrum K; UPMC Health System Office of Healthcare Innovation, Pittsburgh, Pennsylvania, USA.; Clinical Research Investigation and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. SeymourCW; Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; UPMC Health System Office of Healthcare Innovation, Pittsburgh, Pennsylvania, USA.; Clinical Research Investigation and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Montgomery SK; UPMC Health System Office of Healthcare Innovation, Pittsburgh, Pennsylvania, USA.; Clinical Research Investigation and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Angus DC; UPMC Health System Office of Healthcare Innovation, Pittsburgh, Pennsylvania, USA.; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Clinical Research Investigation and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Snyder GM; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Pokaż więcej
Źródło:
Open forum infectious diseases [Open Forum Infect Dis] 2021 May 17; Vol. 8 (7), pp. ofab254. Date of Electronic Publication: 2021 May 17 (Print Publication: 2021).
Comparing the validity of different ICD coding abstraction strategies for sepsis case identification in German claims data.
Autorzy:
Fleischmann-Struzek C; Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany. Thomas-Rüddel DO; Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Department for Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany. Schettler A; Department for Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany. Schwarzkopf D; Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany. Stacke A; Department for Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany. SeymourCW; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.; Clinical Research, Investigation, and Systems Modeling of Acute illness (CRISMA) Center, Pittsburgh, Pennsylvania, United States of America. Haas C; Division of Medical Controlling, Jena University Hospital, Jena, Germany. Dennler U; Division of Medical Controlling, Jena University Hospital, Jena, Germany. Reinhart K; Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Department for Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.
Pokaż więcej
Źródło:
PloS one [PLoS One] 2018 Jul 30; Vol. 13 (7), pp. e0198847. Date of Electronic Publication: 2018 Jul 30 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Geographic access to high capability severe acute respiratory failure centers in the United States.
Autorzy:
Wallace DJ; Clinical Research, Investigation and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America; Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America. Angus DC; Clinical Research, Investigation and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America. SeymourCW; Clinical Research, Investigation and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America; Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America. Yealy DM; Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America. Carr BG; Department of Emergency Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America. Kurland K; Heinz College School of Public Policy and Management, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America. Boujoukos A; Clinical Research, Investigation and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America. Kahn JM; Clinical Research, Investigation and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
Pokaż więcej
Źródło:
PloS one [PLoS One] 2014 Apr 04; Vol. 9 (4), pp. e94057. Date of Electronic Publication: 2014 Apr 04 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Hospital-level variation in the use of intensive care.
Autorzy:
SeymourCW; Departments of Critical Care and Emergency Medicine, University of Pittsburgh School of Medicine, Core Faculty, Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, 639 Scaife Hall 3550 Terrace Street, Pittsburgh, PA 15261, USA. />Iwashyna TJ Ehlenbach WJ Wunsch H Cooke CR
Pokaż więcej
Źródło:
Health services research [Health Serv Res] 2012 Oct; Vol. 47 (5), pp. 2060-80. Date of Electronic Publication: 2012 Mar 30.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies
